chickens

Summary

Summary: Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.

Top Publications

  1. ncbi Whole-genome resequencing reveals loci under selection during chicken domestication
    Carl Johan Rubin
    Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, SE 75123 Uppsala, Sweden
    Nature 464:587-91. 2010
  2. pmc The development and characterization of a 60K SNP chip for chicken
    Martien A M Groenen
    Animal Breeding and Genomics Centre, Wageningen University, The Netherlands
    BMC Genomics 12:274. 2011
  3. pmc Comparative genome analysis of Salmonella Enteritidis PT4 and Salmonella Gallinarum 287/91 provides insights into evolutionary and host adaptation pathways
    Nicholas R Thomson
    The Pathogen Sequencing Unit, The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom
    Genome Res 18:1624-37. 2008
  4. pmc A high-density SNP-based linkage map of the chicken genome reveals sequence features correlated with recombination rate
    Martien A M Groenen
    Animal Breeding and Genomics Centre, Wageningen University, 6700 AH Wageningen, The Netherlands
    Genome Res 19:510-9. 2009
  5. pmc Induced ectopic kinetochore assembly bypasses the requirement for CENP-A nucleosomes
    Karen E Gascoigne
    Whitehead Institute for Biomedical Research, Department of Biology, Nine Cambridge Center, MA 02142, USA
    Cell 145:410-22. 2011
  6. ncbi The avian Z-linked gene DMRT1 is required for male sex determination in the chicken
    Craig A Smith
    Murdoch Children s Research Institute and Department of Paediatrics, The University of Melbourne, Royal Children s Hospital, Melbourne, Victoria 3052, Australia
    Nature 461:267-71. 2009
  7. pmc CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle
    Maximina H Yun
    Division of Protein and Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nature 459:460-3. 2009
  8. pmc Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface
    Julie P I Welburn
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Mol Cell 38:383-92. 2010
  9. pmc Multiple anti-interferon actions of the influenza A virus NS1 protein
    Georg Kochs
    Department of Virology, University of Freiburg, D 79008 Freiburg, Germany
    J Virol 81:7011-21. 2007
  10. pmc A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms
    Gane Ka Shu Wong
    Beijing Institute of Genomics of Chinese Academy of Sciences, Beijing Genomics Institute, Beijing Proteomics Institute, Beijing 101300, China
    Nature 432:717-22. 2004

Detail Information

Publications396 found, 100 shown here

  1. ncbi Whole-genome resequencing reveals loci under selection during chicken domestication
    Carl Johan Rubin
    Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, SE 75123 Uppsala, Sweden
    Nature 464:587-91. 2010
    ..sweeps of favourable alleles and candidate mutations that have had a prominent role in the domestication of chickens (Gallus gallus domesticus) and their subsequent specialization into broiler (meat-producing) and layer (egg-..
  2. pmc The development and characterization of a 60K SNP chip for chicken
    Martien A M Groenen
    Animal Breeding and Genomics Centre, Wageningen University, The Netherlands
    BMC Genomics 12:274. 2011
    ..To be of value in a wide variety of breeds and populations, the success rate of the SNP genotyping assay, the distribution of the SNP across the genome and the minor allele frequencies (MAF) of the SNPs used are extremely important...
  3. pmc Comparative genome analysis of Salmonella Enteritidis PT4 and Salmonella Gallinarum 287/91 provides insights into evolutionary and host adaptation pathways
    Nicholas R Thomson
    The Pathogen Sequencing Unit, The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom
    Genome Res 18:1624-37. 2008
    ..We propose that experimental analysis in chickens and mice of S. Enteritidis-harboring mutations in functional homologs of the pseudogenes present in S...
  4. pmc A high-density SNP-based linkage map of the chicken genome reveals sequence features correlated with recombination rate
    Martien A M Groenen
    Animal Breeding and Genomics Centre, Wageningen University, 6700 AH Wageningen, The Netherlands
    Genome Res 19:510-9. 2009
    ..4-fold higher density at recombination hot spots versus cold spots, suggesting a functional relationship between recombination frequency and cohesin binding...
  5. pmc Induced ectopic kinetochore assembly bypasses the requirement for CENP-A nucleosomes
    Karen E Gascoigne
    Whitehead Institute for Biomedical Research, Department of Biology, Nine Cambridge Center, MA 02142, USA
    Cell 145:410-22. 2011
    ..We additionally find that CENP-T phosphorylation regulates the mitotic assembly of both endogenous and ectopic kinetochores. Thus, CENP-C and CENP-T form a critical regulated platform for vertebrate kinetochore assembly...
  6. ncbi The avian Z-linked gene DMRT1 is required for male sex determination in the chicken
    Craig A Smith
    Murdoch Children s Research Institute and Department of Paediatrics, The University of Melbourne, Royal Children s Hospital, Melbourne, Victoria 3052, Australia
    Nature 461:267-71. 2009
    ..These results indicate that DMRT1 is required for testis determination in the chicken. Our data support the Z dosage hypothesis for avian sex determination...
  7. pmc CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle
    Maximina H Yun
    Division of Protein and Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nature 459:460-3. 2009
    ....
  8. pmc Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface
    Julie P I Welburn
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Mol Cell 38:383-92. 2010
    ..In total, rather than generating exclusively binary changes in microtubule binding, our results suggest a mechanism for the tension-dependent fine-tuning of kinetochore-microtubule interactions...
  9. pmc Multiple anti-interferon actions of the influenza A virus NS1 protein
    Georg Kochs
    Department of Virology, University of Freiburg, D 79008 Freiburg, Germany
    J Virol 81:7011-21. 2007
    ..Our results demonstrate the capacity of FLUAV NS1 to suppress the antiviral host defense at multiple levels and the existence of strain-specific differences that may modulate virus pathogenicity...
  10. pmc A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms
    Gane Ka Shu Wong
    Beijing Institute of Genomics of Chinese Academy of Sciences, Beijing Genomics Institute, Beijing Proteomics Institute, Beijing 101300, China
    Nature 432:717-22. 2004
    ..In fact, most of the SNPs originated before domestication, and there is little evidence of selective sweeps for adaptive alleles on length scales greater than 100 kilobases...
  11. pmc A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability
    Zhijiang Yan
    Laboratory of Genetics, National Institute of Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Mol Cell 37:865-78. 2010
    ..Thus, FANCM-MHF is an essential DNA-remodeling complex that protects replication forks from yeast to human...
  12. pmc Assembly of centrosomal proteins and microtubule organization depends on PCM-1
    Alexander Dammermann
    Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Mayfield Road, Edinburgh EH9 3JR, Scotland, UK
    J Cell Biol 159:255-66. 2002
    ....
  13. ncbi The chicken B locus is a minimal essential major histocompatibility complex
    J Kaufman
    Institute for Animal Health, Compton, UK
    Nature 401:923-5. 1999
    Here we report the sequence of the region that determines rapid allograft rejection in chickens, the chicken major histocompatibility complex (MHC)...
  14. pmc Occludin: a novel integral membrane protein localizing at tight junctions
    M Furuse
    Department of Information Physiology, National Institute for Physiological Sciences, Aichi, Japan
    J Cell Biol 123:1777-88. 1993
    ..These findings revealed that an integral membrane protein localizing at tight junctions is now identified, which we designated as "occludin."..
  15. pmc Association of RIG-I with innate immunity of ducks to influenza
    Megan R W Barber
    Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada
    Proc Natl Acad Sci U S A 107:5913-8. 2010
    ..Ducks are often resistant to influenza viruses capable of killing chickens. Here, we show that the influenza virus sensor, RIG-I, is present in ducks and plays a role in clearing an ..
  16. pmc Immune response of chicken gut to natural colonization by gut microflora and to Salmonella enterica serovar enteritidis infection
    Magdalena Crhanova
    Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic
    Infect Immun 79:2755-63. 2011
    In commercial poultry production, there is a lack of natural flora providers since chickens are hatched in the clean environment of a hatchery...
  17. ncbi Identification of Campylobacter jejuni genes involved in commensal colonization of the chick gastrointestinal tract
    David R Hendrixson
    Unit for Laboratory Animal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0620, USA
    Mol Microbiol 52:471-84. 2004
    ..jejuni revealed one other required for wild-type levels of caecal colonization. This study represents one of the first genetic screens focusing on the bacterial requirements necessary for promoting commensalism in a vertebrate host...
  18. pmc Campylobacter genotyping to determine the source of human infection
    Samuel K Sheppard
    Department of Zoology, University of Oxford, Oxford, United Kingdom
    Clin Infect Dis 48:1072-8. 2009
    ....
  19. pmc Characterization of chicken spleen transcriptome after infection with Salmonella enterica serovar Enteritidis
    Marta Matulova
    Veterinary Research Institute, Brno, Czech Republic
    PLoS ONE 7:e48101. 2012
    ..To reach this aim, gene expression in the spleens of naive chickens and those intravenously infected with S...
  20. pmc The genome of a songbird
    Wesley C Warren
    The Genome Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA
    Nature 464:757-62. 2010
    ..These results indicate an active involvement of the genome in neural processes underlying vocal communication and identify potential genetic substrates for the evolution and regulation of this behaviour...
  21. pmc A complex genomic rearrangement involving the endothelin 3 locus causes dermal hyperpigmentation in the chicken
    Ben Dorshorst
    Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS Genet 7:e1002412. 2011
    ..This complex genomic rearrangement causing a specific monogenic trait in the chicken illustrates how novel mutations with major phenotypic effects have been reused during breed formation in domestic animals...
  22. pmc Continued evolution of H5N1 influenza viruses in wild birds, domestic poultry, and humans in China from 2004 to 2009
    Yanbing Li
    Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, 427 Maduan Street, Harbin 150001, People s Republic of China
    J Virol 84:8389-97. 2010
    ..addition, antigenically drifted H5N1 viruses, represented by A/chicken/Shanxi/2/06 (CK/SX/2/06), were detected in chickens from several provinces in northern China...
  23. pmc Copy number variation in intron 1 of SOX5 causes the Pea-comb phenotype in chickens
    Dominic Wright
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS Genet 5:e1000512. 2009
    Pea-comb is a dominant mutation in chickens that drastically reduces the size of the comb and wattles. It is an adaptive trait in cold climates as it reduces heat loss and makes the chicken less susceptible to frost lesions...
  24. ncbi Domestic-animal genomics: deciphering the genetics of complex traits
    Leif Andersson
    Department of Medical Biochemistry and Microbiology, Uppsala University, Box 597, SE 751 24 Uppsala, Sweden
    Nat Rev Genet 5:202-12. 2004
  25. pmc An initial map of chromosomal segmental copy number variations in the chicken
    Xiaofei Wang
    Department of Biological Sciences, Tennessee State University, Nashville, TN 37209, USA
    BMC Genomics 11:351. 2010
    ..A map of CNVs in chickens could facilitate the identification of chromosomal regions that segregate for important agricultural and disease ..
  26. pmc Chickens possess centromeres with both extended tandem repeats and short non-tandem-repetitive sequences
    Wei Hao Shang
    Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies SOKENDAI, Mishima, Shizuoka 411 8540, Japan
    Genome Res 20:1219-28. 2010
    ....
  27. ncbi Ciprofloxacin resistance in Campylobacter jejuni evolves rapidly in chickens treated with fluoroquinolones
    Patrick F McDermott
    Division of Animal and Food Microbiology, Center for Veterinary Medicine, US Food and Drug Administration, Laurel, Maryland 20708, USA
    J Infect Dis 185:837-40. 2002
    ..In separate experiments, the effects of sarafloxacin and enrofloxacin treatment of Campylobacter jejuni-infected chickens on the development of ciprofloxacin resistance were measured...
  28. pmc Association of increased pathogenicity of Asian H5N1 highly pathogenic avian influenza viruses in chickens with highly efficient viral replication accompanied by early destruction of innate immune responses
    Koutaro Suzuki
    Research Team for Zoonotic Diseases, National Institute of Animal Health NIAH, National Agriculture and Food Research Organization NARO, 3 1 5 Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    J Virol 83:7475-86. 2009
    ..To better understand the basis of the increased pathogenicity of recent Asian H5N1 HPAI viruses in chickens, we compared the fevers and mean death times (MDTs) of chickens infected with the Asian H5N1 A/chicken/Yamaguchi/..
  29. pmc Genome-wide association study of body weight in chicken F2 resource population
    Xiaorong Gu
    State Key Laboratory for Agro Biotechnology, China Agricultural University, Beijing, People s Republic of China
    PLoS ONE 6:e21872. 2011
    ..GGA1 and GGA18 had three SNP effects on body weight with genome-wide significance. Some of the SNP effects with the significance of "suggestive linkage" overlapped with previously reported results...
  30. pmc Acquisition of human-type receptor binding specificity by new H5N1 influenza virus sublineages during their emergence in birds in Egypt
    Yohei Watanabe
    Department of Virology, Research Institute for Microbial Diseases BIKEN, Osaka University, Osaka, Japan
    PLoS Pathog 7:e1002068. 2011
    ..Our findings suggested that emergence of new H5 sublineages with α2,6 SA specificity caused a subsequent increase in human H5N1 influenza virus infections in Egypt, and provided data for understanding the virus's pandemic potential...
  31. ncbi Structural basis for vinculin activation at sites of cell adhesion
    Constantina Bakolitsa
    Program on Cell Adhesion, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 430:583-6. 2004
    ....
  32. pmc The dominantly expressed class I molecule of the chicken MHC is explained by coevolution with the polymorphic peptide transporter (TAP) genes
    Brian A Walker
    Institute for Animal Health, Compton RG20 7NN, United Kingdom
    Proc Natl Acad Sci U S A 108:8396-401. 2011
    ..In chickens, there are two classical class I genes but only one is expressed at a high level, which can result in strong MHC ..
  33. ncbi Aromatase mRNA in the extragonadal tissues of chickens with the henny-feathering trait is derived from a distinctive promoter structure that contains a segment of a retroviral long terminal repeat. Functional organization of the Sebright, Leghorn, and Cam
    H Matsumine
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235 8857
    J Biol Chem 266:19900-7. 1991
    ..that causes the expression of aromatase activity and accumulation of aromatase mRNA in extragonadal tissues of chickens. The current studies establish that the aromatase gene is not amplified and is organized similarly in control (..
  34. pmc Phase variable expression of capsular polysaccharide modifications allows Campylobacter jejuni to avoid bacteriophage infection in chickens
    Martine C Holst Sørensen
    Department of Veterinary Disease Biology, University of Copenhagen Frederiksberg, Denmark
    Front Cell Infect Microbiol 2:11. 2012
    ..Furthermore, co-infection of chickens with both C. jejuni NCTC11168 and phage F336 resulted in selection of resistant C...
  35. pmc Identification of the yellow skin gene reveals a hybrid origin of the domestic chicken
    Jonas Eriksson
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS Genet 4:e1000010. 2008
    Yellow skin is an abundant phenotype among domestic chickens and is caused by a recessive allele (W*Y) that allows deposition of yellow carotenoids in the skin...
  36. pmc An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes
    G N Filippova
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Mol Cell Biol 16:2802-13. 1996
    ..e., c-myc) of different vertebrate species are regulated by the same factor and maintain similar expression patterns despite significant promoter sequence divergence...
  37. ncbi Vaccination with Clostridium perfringens recombinant proteins in combination with Montanide™ ISA 71 VG adjuvant increases protection against experimental necrotic enteritis in commercial broiler chickens
    Seung I Jang
    Animal Parasitic Diseases Laboratory, Animal and Natural Resources Institute, Agricultural Research Service US Department of Agriculture, Beltsville, MD 20705, USA
    Vaccine 30:5401-6. 2012
    ..Broiler chickens were immunized subcutaneously with purified clostridial recombinant NetB toxin, pyruvate: ferredoxin ..
  38. ncbi A genome-wide survey of copy number variation regions in various chicken breeds by array comparative genomic hybridization method
    Y Wang
    State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China
    Anim Genet 43:282-9. 2012
    ..Studies with chickens have identified a number of large CNV segments using a 385k comparative genomic hybridization (CGH) chip (mean ..
  39. ncbi LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability
    M J Nadler
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 411:590-5. 2001
    ..Our data indicate that LTRPC7, by virtue of its sensitivity to physiological Mg.ATP levels, may be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell...
  40. pmc Rapid expression of chemokines and proinflammatory cytokines in newly hatched chickens infected with Salmonella enterica serovar typhimurium
    G S K Withanage
    Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, United Kingdom
    Infect Immun 72:2152-9. 2004
    ..However, the exact nature of the immune mechanisms protective against Salmonella infection in chickens has not been characterized at the molecular level...
  41. pmc Modulations of the chicken cecal microbiome and metagenome in response to anticoccidial and growth promoter treatment
    Jessica L Danzeisen
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota, United States of America
    PLoS ONE 6:e27949. 2011
    ..Using a longitudinal design, cecal contents of commercial chickens were extracted and examined using 16S rRNA and total DNA shotgun metagenomic pyrosequencing...
  42. pmc The CENP-S complex is essential for the stable assembly of outer kinetochore structure
    Miho Amano
    Department of Molecular Genetics, National Institute of Genetics, The Graduate University for Advanced Studies, Mishima, Shizuoka 411 8540, Japan
    J Cell Biol 186:173-82. 2009
    ..In addition, we found that intrakinetochore distance was increased in CENP-S- and CENP-X-deficient cells. These results suggest that the CENP-S complex is essential for the stable assembly of the outer kinetochore...
  43. ncbi ATR-ATRIP kinase complex triggers activation of the Fanconi anemia DNA repair pathway
    Tomoko Shigechi
    Laboratory of DNA Damage Signaling, Department of Late Effects Studies, Radiation Biology Center, Kyoto University, Kyoto, Japan
    Cancer Res 72:1149-56. 2012
    ..Together, our findings identify ATR as the kinase responsible for activating the FA pathway of DNA repair...
  44. pmc A systematic analysis of the skeletal muscle miRNA transcriptome of chicken varieties with divergent skeletal muscle growth identifies novel miRNAs and differentially expressed miRNAs
    Tingting Li
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China
    BMC Genomics 12:186. 2011
    ..To investigate the functional roles that miRNAs play during chicken skeletal muscle development, the miRNA transcriptomes of skeletal muscles from broiler and layer chickens were profiled using Solexa deep sequencing.
  45. ncbi Ultraconserved elements in the human genome
    Gill Bejerano
    Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA 95064, USA
    Science 304:1321-5. 2004
    ....
  46. ncbi Risk factors for indigenous Campylobacter jejuni and Campylobacter coli infections in The Netherlands: a case-control study
    Y Doorduyn
    Epidemiology and Surveillance Unit, Netherlands Centre for Infectious Disease Control, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Epidemiol Infect 138:1391-404. 2010
    ..jejuni infections. This study illustrates that important differences in risk factors exist for different Campylobacter spp. and these may differ dependent on age, season or degree of urbanization...
  47. ncbi Sex determination: insights from the chicken
    Craig A Smith
    Murdoch Childrens Research Institute and Department of Paediatrics, Royal Childrens Hospital, Parkville, Victoria, Australia
    Bioessays 26:120-32. 2004
    ..The Z-linked gene, DMRT1, supports the Z-dosage model of avian sex determination. Two novel W-linked genes, ASW and FET1, represent candidate female determinants...
  48. ncbi Mechanisms of DNA double strand break repair and chromosome aberration formation
    G Iliakis
    Institute of Medical Radiation Biology, University of Duisburg Essen Medical School, Essen, Germany
    Cytogenet Genome Res 104:14-20. 2004
    ..The slow kinetics and suboptimal synapsis mechanisms of B-NHEJ allow more time for exchanges through the joining of incorrect ends and cause the formation of chromosome aberrations in wild type and D-NHEJ mutant cells...
  49. pmc Evolution of the chicken Toll-like receptor gene family: a story of gene gain and gene loss
    Nicholas D Temperley
    Department of Genomics and Genetics, Roslin Institute Edinburgh, Roslin, Midlothian EH25 9PS, UK
    BMC Genomics 9:62. 2008
    ..This study takes advantage of the recently sequenced chicken genome to determine the complete chicken TLR repertoire and place it in context of vertebrate genomic evolution...
  50. ncbi Genetic mapping of quantitative trait loci affecting growth and carcass traits in F2 intercross chickens
    Y Uemoto
    National Livestock Breeding Center, Nishigo, Fukushima 961 8511, Japan
    Poult Sci 88:477-82. 2009
    ..An F(2) population comprising 240 chickens obtained by crossing a Shamo (lean, lightweight Japanese native breed) male and White Plymouth Rock breed (fat, ..
  51. ncbi Age at primary infection with Salmonella enterica serovar Typhimurium in the chicken influences persistence of infection and subsequent immunity to re-challenge
    R K Beal
    Division of Immunology and Immunopathology, Institute for Animal Health, Compton Laboratory, Compton, Newbury RG20 7NN, UK
    Vet Immunol Immunopathol 100:151-64. 2004
    ..enterica serovar Typhimurium results in a persistent enteric infection without clinical disease in chickens of more than 3 days of age, and represents a source for contamination of carcass at slaughter and entry into the ..
  52. ncbi The evolutionary fate and consequences of duplicate genes
    M Lynch
    Department of Biology, University of Oregon, Eugene, OR 97403, USA
    Science 290:1151-5. 2000
    ..Although duplicate genes may only rarely evolve new functions, the stochastic silencing of such genes may play a significant role in the passive origin of new species...
  53. pmc Chicken cells sense influenza A virus infection through MDA5 and CARDIF signaling involving LGP2
    Matthias Liniger
    Institute of Virology and Immunoprophylaxis IVI, Mittelhausern, Switzerland
    J Virol 86:705-17. 2012
    ..While infection with highly pathogenic AIV results in high mortality in chickens, this is not necessarily the case in wild birds and ducks...
  54. pmc A genome-wide SNP scan reveals novel loci for egg production and quality traits in white leghorn and brown-egg dwarf layers
    Wenbo Liu
    National Engineering Laboratory for Animal Breeding and MOA Key Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, China
    PLoS ONE 6:e28600. 2011
    ..genome sequence as well as high-density SNP genotyping platforms allows genome-wide association studies (GWAS) in chickens. A high-density SNP array containing 57,636 markers was employed herein to identify associated variants ..
  55. pmc Genome-wide association study identified a narrow chromosome 1 region associated with chicken growth traits
    Liang Xie
    Guangdong Provincial Key Lab of Agro Animal Genomics and Molecular Breeding, Guangzhou, Guangdong, China
    PLoS ONE 7:e30910. 2012
    ..Gallus gallus) chromosome (GGA) 1 to be strongly associated with chicken growth using 47,678 SNPs and 489 F2 chickens. The growth traits included aggregate body weight (BW) at 0-90 d of age measured weekly, biweekly average daily ..
  56. ncbi Genotoxic effects of deoxynivalenol in broiler chickens fed low-protein feeds
    W A Awad
    Clinic for Avian, Reptile and Fish Medicine, University of Veterinary Medicine, Veterinarplatz 1, A 1210 Vienna, Austria
    Poult Sci 91:550-5. 2012
    ..mycotoxin DON at moderate levels in combination with low-protein feed are able to induce lymphocyte DNA damage in chickens. Supplementation with Mycofix select protected lymphocyte DNA and it was beneficial for maintaining the ..
  57. pmc ATR activation and replication fork restart are defective in FANCM-deficient cells
    Rebekka A Schwab
    Department of Molecular Oncology, Weatherall Institute of Molecular Medicine, Oxford University, Oxford, UK
    EMBO J 29:806-18. 2010
    ..Our data therefore indicate a fundamental role for FANCM in the maintenance of genome integrity during S phase...
  58. ncbi Overexpression of the neural growth-associated protein GAP-43 induces nerve sprouting in the adult nervous system of transgenic mice
    L Aigner
    Friedrich Miescher Institute, Basel, Switzerland
    Cell 83:269-78. 1995
    ..A mutant GAP-43 that cannot be phosphorylated by PKC had reduced sprout-promoting activity. The results establish GAP-43 as an intrinsic presynaptic determinant for neurite outgrowth and plasticity...
  59. pmc Signatures of selection in the genomes of commercial and non-commercial chicken breeds
    Martin G Elferink
    Animal Breeding and Genomics Centre, Wageningen University and Research Centre, Wageningen, The Netherlands
    PLoS ONE 7:e32720. 2012
    ..We analyzed commercial chickens representing all major breeding goals...
  60. pmc Influenza virus A (H10N7) in chickens and poultry abattoir workers, Australia
    George G Arzey
    Elizabeth Macarthur Agricultural Institute, Menangle, New South Wales, Australia
    Emerg Infect Dis 18:814-6. 2012
    ..After processing clinically normal birds from the farm, 7 abattoir workers reported conjunctivitis and minor upper respiratory tract symptoms. Influenza virus A subtype H10 infection was detected in 2 workers...
  61. ncbi Different evolutionary histories of the two classical class I genes BF1 and BF2 illustrate drift and selection within the stable MHC haplotypes of chickens
    Iain Shaw
    Institute for Animal Health, Compton, Berkshire, United Kingdom
    J Immunol 178:5744-52. 2007
    ....
  62. ncbi Genome-wide association analysis and genetic architecture of egg weight and egg uniformity in layer chickens
    A Wolc
    Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska street 33, 60 637 Poznan, Poland
    Anim Genet 43:87-96. 2012
    ..The region on chromosome 4 can be used to improve both the mean and standard deviation of egg weight by marker-assisted selection...
  63. pmc Indirect genetic effects for survival in domestic chickens (Gallus gallus) are magnified in crossbred genotypes and show a parent-of-origin effect
    K Peeters
    Animal Breeding and Genomics Centre, Wageningen University, 6700 AH Wageningen, The Netherlands
    Genetics 192:705-13. 2012
    ..We studied IGEs for survival in domestic chickens (Gallus gallus), using data on two purebred lines and their reciprocal cross. Birds were kept in groups of four...
  64. ncbi Dynamics of passive immunity to West Nile virus in domestic chickens (Gallus gallus domesticus)
    Nicole M Nemeth
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523 1683, USA
    Am J Trop Med Hyg 76:310-7. 2007
    ..There were significant age-related differences in WNV-attributed morbidity and viremia levels of unprotected chicks. Vertical transmission of WNV was not detected...
  65. pmc Seroprevalence of Toxoplasma gondii infection in slaughtered chickens, ducks, and geese in Shenyang, northeastern China
    Na Yang
    College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, Liaoning Province 110866, China
    Parasit Vectors 5:237. 2012
    In recent years, investigations of Toxoplasma gondii infection in poultry (chickens, ducks, and geese) have been reported worldwide, including China. However, little is known about the prevalence of T...
  66. pmc Reproducing kernel hilbert spaces regression methods for genomic assisted prediction of quantitative traits
    Daniel Gianola
    Department of Animal Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 178:2289-303. 2008
    ..Models for capturing different forms of interaction, e.g., chromosome-specific, are presented. Implementations can be carried out using software for likelihood-based or Bayesian inference...
  67. ncbi Newcastle disease: evolution of genotypes and the related diagnostic challenges
    Patti J Miller
    Exotic and Emerging Avian Viral Diseases Research Unit, Southeast Poultry Research Laboratory, 934 College Station Road, Athens, GA 30052, USA
    Infect Genet Evol 10:26-35. 2010
    ..Here, we review the molecular epidemiology and recent diagnostic problems related to viral evolution of NDV and explain why a new system, based on objective criteria, is needed to categorize genotypes...
  68. ncbi Highly pathogenic (H5N1) avian influenza induces an inflammatory T helper type 1 cytokine response in the chicken
    Adam J Karpala
    CSIRO, Livestock Industries, Australian Animal Health Laboratory, Geelong, Australia
    J Interferon Cytokine Res 31:393-400. 2011
    ..understand the immune response to highly pathogenic avian influenza virus, we compared expression of cytokines in chickens infected with avian influenza virus (A/Vietnam/1203/04) to that in uninfected chickens...
  69. pmc NetB, a new toxin that is associated with avian necrotic enteritis caused by Clostridium perfringens
    Anthony L Keyburn
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
    PLoS Pathog 4:e26. 2008
    ..NetB was only identified in C. perfringens type A strains isolated from chickens suffering NE...
  70. pmc Isolation and characterization of potentially pathogenic antimicrobial-resistant Escherichia coli strains from chicken and pig farms in Spain
    Pilar Cortés
    Departament de Genetica i de Microbiologia, Universitat Autonoma de Barcelona, 08193 Cerdanyola del Valles, Barcelona, Spain
    Appl Environ Microbiol 76:2799-805. 2010
    ..coli...
  71. pmc USF1 recruits histone modification complexes and is critical for maintenance of a chromatin barrier
    Suming Huang
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0540, USA
    Mol Cell Biol 27:7991-8002. 2007
    ..These results show that USF1 plays a direct role in maintaining the barrier, supporting a model in which the insulator works as a barrier by maintaining a local environment of active chromatin...
  72. ncbi Antiviral activity of the long chain pentraxin PTX3 against influenza viruses
    Patrick C Reading
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    J Immunol 180:3391-8. 2008
    ....
  73. ncbi The Fanconi anaemia gene FANCC promotes homologous recombination and error-prone DNA repair
    Wojciech Niedzwiedz
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Mol Cell 15:607-20. 2004
    ..These studies reveal that the FA proteins cooperate with key mutagenesis and repair processes that enable replication of damaged DNA...
  74. pmc Heritable genome-wide variation of gene expression and promoter methylation between wild and domesticated chickens
    Daniel Nätt
    IFM Biology, Division of Zoology, Avian Behavioural Genomics and Physiology Group, Linkoping University, Sweden
    BMC Genomics 13:59. 2012
    ....
  75. pmc Selection of H5N1 influenza virus PB2 during replication in humans
    Quynh Mai Le
    National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
    J Virol 83:5278-81. 2009
    ..Viruses grown in culture or eggs did not always reflect those in patients. These results emphasize the importance of the direct analysis of original specimens...
  76. ncbi Early learning and the development of filial preferences in the chick
    J J Bolhuis
    University of Cambridge, Sub Department of Animal Behaviour, Madingley, UK
    Behav Brain Res 98:245-52. 1999
    ..In the natural situation, the animal's response may be biased by the predisposition, and through imprinting it then learns the characteristics of individuals...
  77. pmc Salmonella enterica serovar gallinarum requires ppGpp for internalization and survival in animal cells
    Jae Ho Jeong
    Department of Microbiology, Chonnam National University Medical College, Gwangju 501 746, South Korea
    J Bacteriol 190:6340-50. 2008
    ..It was concluded that Salmonella serovar Gallinarum internalizes animal cells by a mechanism independent of SPI-1 genes but dependent on ppGpp. Intracellular growth also required ppGpp for the transcription of genes encoded in SPI-2...
  78. pmc Transcriptome analysis of avian pathogenic Escherichia coli O1 in chicken serum reveals adaptive responses to systemic infection
    Ganwu Li
    Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, 1802 University Blvd, Ames, IA 50011, USA
    Infect Immun 79:1951-60. 2011
    ..This genome-wide analysis provides novel insight into processes that are important to the pathogenesis of APEC O1...
  79. ncbi Recombinant chicken interferon-α inhibits H9N2 avian influenza virus replication in vivo by oral administration
    Shanshan Meng
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People s Republic of China
    J Interferon Cytokine Res 31:533-8. 2011
    ..of ChIFN-α as an oral antiviral agent on avian influenza virus (AIV) infection has not been fully clarified in chickens systemically...
  80. ncbi Characterization of the complete mitochondrial genomes of five Eimeria species from domestic chickens
    Rui Qing Lin
    Department of Parasitology, State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, CAAS, Lanzhou, Gansu, PR China
    Gene 480:28-33. 2011
    ..and should have implications for the molecular diagnosis, prevention and control of coccidiosis in domestic chickens.
  81. pmc The Meq oncoprotein of Marek's disease virus interacts with p53 and inhibits its transcriptional and apoptotic activities
    Xufang Deng
    Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai 200241, PR China
    Virol J 7:348. 2010
    Marek's disease virus (MDV) is an oncogenic herpesvirus, which causes malignant lymphoma in chickens. The Meq protein of MDV, which is expressed abundantly in MDV-infected cells and in Marek's disease (MD) tumor cells, functions as a ..
  82. pmc Integrative mapping analysis of chicken microchromosome 16 organization
    Romain Solinhac
    UMR INRA ENVT Laboratoire de Génétique Cellulaire, INRA, Castanet Tolosan, 31326, France
    BMC Genomics 11:616. 2010
    ..The purpose of the present study is to construct and present high resolution integrated maps of GGA16 to refine its organization and improve its coverage with genetic markers...
  83. pmc The recombination landscape of the zebra finch Taeniopygia guttata genome
    Niclas Backstrom
    Department of Evolutionary Biology, Uppsala University, SE 752 36 Uppsala, Sweden
    Genome Res 20:485-95. 2010
    ..Levels of linkage disequilibrium (LD) were significantly higher in regions of low recombination, showing that heterogeneity in recombination rates have left a footprint on the genomic landscape of LD in zebra finch populations...
  84. pmc Genetic control of resistance to salmonellosis and to Salmonella carrier-state in fowl: a review
    Fanny Calenge
    INRA, UR Unité de Recherches Avicoles, Nouzilly, France
    Genet Sel Evol 42:11. 2010
    ..This article reviews the main Salmonella infection models and chicken lines studied under a historical perspective and then the candidate genes and QTL identified so far...
  85. pmc Risk for infection with highly pathogenic avian influenza virus (H5N1) in backyard chickens, Bangladesh
    Paritosh K Biswas
    Department of Microbiology, Chittagong Veterinary and Animal Sciences University, Khulshi, Chittagong, Bangladesh
    Emerg Infect Dis 15:1931-6. 2009
    To evaluate risk factors for infection with highly pathogenic avian influenza A virus (H5N1) in backyard chickens in Bangladesh, we conducted a matched case-control study...
  86. ncbi Herpesvirus of turkey reconstituted from bacterial artificial chromosome clones induces protection against Marek's disease
    Susan J Baigent
    Institute for Animal Health, Compton Laboratory, Compton, Newbury, Berkshire RG20 7NN, UK
    J Gen Virol 87:769-76. 2006
    ..Furthermore, the availability of the BAC clones enables use of HVT as a vector for expressing foreign genes...
  87. ncbi Inhibition of glycogenolysis in astrocytes interrupts memory consolidation in young chickens
    Marie E Gibbs
    Department of Anatomy and Cell Biology, Monash University, Clayton, Australia
    Glia 54:214-22. 2006
    Glycolysis and glycogenolysis are involved in memory processing in day-old chickens and, aside from the provision of energy for neuronal and astrocytic energy metabolism these pathways enable astrocytes to supply neurones with precursor ..
  88. ncbi Epistasis and the release of genetic variation during long-term selection
    Orjan Carlborg
    Linnaeus Centre for Bioinformatics, Uppsala University, Box 598, SE 75124 Uppsala, Sweden
    Nat Genet 38:418-20. 2006
    ..The interactions in this radial network mediate a considerably larger selection response than predicted by a single-locus model...
  89. ncbi Transgenic chickens as bioreactors for protein-based drugs
    Simon G Lillico
    Roslin Institute, Roslin, Midlothian EH25 9PS, UK
    Drug Discov Today 10:191-6. 2005
    ....
  90. pmc Species and age related differences in the type and distribution of influenza virus receptors in different tissues of chickens, ducks and turkeys
    Smitha P S Pillai
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio 44691, USA
    Virol J 7:5. 2010
    ..sialic acid (SA)-galactose (gal) (avian type) and alpha2,6SA-gal (human type) receptors on different tissues of chickens, ducks and turkeys of varying age groups...
  91. ncbi Molecular epidemiology of chicken anemia virus in Nigeria
    M F Ducatez
    Institute of Immunology, Laboratoire National de Santé, Luxembourg, Grand Duchy of Luxembourg
    Arch Virol 151:97-111. 2006
    ..This first molecular epidemiological study of CAV in Africa shows that the Nigerian strains cluster with viruses from very diverse geographic origins and were almost as diverse (4.4%) as all other strains combined (5.8%)...
  92. ncbi A physical map of the chicken genome
    John W Wallis
    Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA
    Nature 432:761-4. 2004
    ..This map represents approximately 91% of the chicken genome and enables identification of chicken clones aligned to positions in other sequenced genomes...
  93. ncbi Virulence of Newcastle disease virus is determined by the cleavage site of the fusion protein and by both the stem region and globular head of the haemagglutinin-neuraminidase protein
    Olav S de Leeuw
    Wageningen University and Research Centre, Animal Sciences Group, Division of Infectious Diseases, 8200 AB Lelystad, The Netherlands
    J Gen Virol 86:1759-69. 2005
    ..The effect of the HN protein on virulence was most prominent after intravenous inoculation. Interestingly, both the stem region and the globular head of the HN protein seem to be involved in determining virulence...
  94. pmc 16S rRNA-based analysis of microbiota from the cecum of broiler chickens
    Xiang Y Zhu
    Department of Animal and Food Sciences, University of Delaware, Newark, Delaware 19717 1301, USA
    Appl Environ Microbiol 68:124-37. 2002
    The microbiota of the intestinal tract of chickens plays an important role in inhibiting the establishment of intestinal pathogens...
  95. pmc The NS1 gene contributes to the virulence of H5N1 avian influenza viruses
    Zejun Li
    Harbin Veterinary Research Institute, CAAS, 427 Maduan Street, Harbin 150001, People s Republic of China
    J Virol 80:11115-23. 2006
    ..study, we explored the genetic basis underlying the virulence and host range of two H5N1 influenza viruses in chickens. A/goose/Guangdong/1/96 (GS/GD/1/96) is a highly pathogenic virus for chickens, whereas A/goose/Guangdong/2/96 (..
  96. pmc Genome-wide effects of long-term divergent selection
    Anna M Johansson
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
    PLoS Genet 6:e1001188. 2010
    ....
  97. ncbi Colibacillosis in poultry: unravelling the molecular basis of virulence of avian pathogenic Escherichia coli in their natural hosts
    Francis Dziva
    Division of Microbiology, Institute for Animal Health, Compton, Newbury, Berkshire, UK
    Avian Pathol 37:355-66. 2008
    ..Collectively, such information provides the basis for the development or improvement of strategies to control APEC infections in the food-producing avian species...
  98. pmc Genome-wide assessment of worldwide chicken SNP genetic diversity indicates significant absence of rare alleles in commercial breeds
    William M Muir
    Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA
    Proc Natl Acad Sci U S A 105:17312-7. 2008
    ..and industry consolidation are predicted to have major impacts on the genetic composition of commercial chickens. Consequently, the question arises as to whether sufficient genetic diversity remains within industry stocks to ..
  99. pmc Cross-reactive, cell-mediated immunity and protection of chickens from lethal H5N1 influenza virus infection in Hong Kong poultry markets
    S H Seo
    Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA
    J Virol 75:2516-25. 2001
    In 1997, avian H5N1 influenza virus transmitted from chickens to humans resulted in 18 confirmed infections. Despite harboring lethal H5N1 influenza viruses, most chickens in the Hong Kong poultry markets showed no disease signs...
  100. pmc Genetic analysis of an F(2) intercross between two chicken lines divergently selected for body-weight
    Per Wahlberg
    Department of Medical Biochemistry and Microbiology, Uppsala University, BMC, Uppsala, Sweden
    BMC Genomics 10:248. 2009
    ..Furthermore, we utilized genotype data from ~13,000 SNPs to search the genome for potential selective sweeps that have occurred in the selected lines...

Research Grants64

  1. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
    ..the vast majority of species that do not have it - non-human primates, rodents, suboscine songbirds, pigeons, chickens, etc.1,2...
  2. Herpesvirus-induced telomerase dysregulation and tumor formation
    Keith William Jarosinski; Fiscal Year: 2011
    ..Marek's disease virus (MDV) is a herpesvirus of chickens that causes a highly malignant T cell lymphoma...
  3. Case-Cohort Study of Cancers in Excess in Poultry Workers
    Eric S Johnson; Fiscal Year: 2013
    Johnson, Eric, S Certain retroviruses and herpesvirus naturally and commonly infect and cause cancer in chickens and turkeys. These viruses include some of the most potent cancer-causing agents known in animals...
  4. The role of the primitive choana in amniote craniofacial morphogenesis
    John Abramyan; Fiscal Year: 2013
    ..Mice have a complete secondary palate, chickens have a natural cleft palate and turtles have primitive palate...
  5. A novel Salmonella vaccine to protect against extra intestinal pathogenic E. coli
    Melha Mellata; Fiscal Year: 2011
    ..ExPEC strains also infect chickens causing economic losses for the poultry industry, a significant economic sector in the US and globally, due to ..
  6. Hair cell development of zebrafish mutants with defects in the marginal zone
    JONATHAN MATSUI; Fiscal Year: 2010
    ..mammalian hair cells do not regenerate after damage, hair cells of non-mammalian vertebrates including fish and chickens can regenerate...
  7. Role of SUSD4 in Retinal Development and Function
    Feng Lin; Fiscal Year: 2010
    ..Using the refolded recombinant SUSD4 protein, we raised antibodies in chickens. We found that SUSD4 is only detectable in murine eyes, brains, spinal cords and testes, and in eyes its ..
  8. Oncogenes and oncogenic microRNAs in chicken tumors
    Karen L Beemon; Fiscal Year: 2012
    ..Recently, activation of TERT by avian leukosis virus (ALV) integration was observed in B-cell lymphomas in chickens. Since the TERT integrations were clonal, this appears to be an early event in tumor development...
  9. Survival Mechanisms of Invasive Carcinoma Cells
    Richard L Klemke; Fiscal Year: 2013
    ..that combines high resolution confocal microscopy with unique animal models (optically transparent zebrafish and chickens) that facilitate direct visualization of cells undergoing distinct steps in the metastastic cascade in ..
  10. Robo-Slit Signaling in Avian Cornea Innervation
    Tyler Schwend; Fiscal Year: 2013
    ..organ cultures and in ovo electroporation so that the pathway may be studied in living organs and developing chickens. These studies will help to determine the overall function of the pathway on cornea innervation, in addition to ..
  11. Antimicrobial peptide resistance in Campylobacter jejuni
    Jun Lin; Fiscal Year: 2010
    ..jejuni colonization in chickens and are being directed toward on-farm control of this pathogen to protect public health...
  12. Regulation of the v-Myb and c-Myb Oncoproteins
    Scott A Ness; Fiscal Year: 2010
    ..giving it the ability to transform hematopoietic cells in tissue culture and induce leukemias and lymphomas in chickens and mice...
  13. In-ovo vaccination/avian influenza/bird/human
    DE CHU CHRISTOPHER TANG; Fiscal Year: 2010
    ..We have demonstrated that chickens can be immunized against highly pathogenic avian influenza viruses by in ovo administration of non-replicating ..
  14. Defining ATOH1 function and regulation in avian supporting cells
    Rebecca Lewis; Fiscal Year: 2013
    ..Post-hatch chickens will be used to test these hypotheses in addition to organotypic cultures, gene misexpression tools, and ..
  15. A Chicken Model to Study Hepatitis E Virus Pathogenesis
    Xiang Jin Meng; Fiscal Year: 2013
    ..We will determine if depletion of specific CD4+ or CD8+ T cell subsets in chickens will lead to chronic infection and severe hepatitis in chickens infected with avian HEV...
  16. Fimbrial expression in Salmonella: regulation and coordination
    Steven Clegg; Fiscal Year: 2010
    ..In both hosts, humans and chickens, the pathogen colonizes and grows in the gastrointestinal (GI) tract...
  17. Malaria Erythrocyte Binding-like Genes &Host Specificity in a Natural Population
    RAVINDER NATH MARIUS SEHGAL; Fiscal Year: 2011
    ..gallinaceum, a parasite of chickens. With this information, we shall isolate orthologous genes from natural populations of birds, with the intent to ..
  18. Monitoring nanoparticle biology in vivo: unique opportunities in the avian system
    Gisela F Erf; Fiscal Year: 2013
    ..In chickens, the ensheathed living portion of a GF is a define unit of tissue approx...
  19. ROLE OF PEPTIDES IN OCULOMOTOR NEUROTRANSMISSION
    VINCENT CHIAPPINELLI; Fiscal Year: 1992
    ..Intact ciliary ganglia obtained from chick embryos and hatched chickens will be studied in an in vitro electrophysiological chamber...
  20. PEPTIDE BASED SALMONELLA VACCINE DELIVERY SYSTEM
    Lee Riley; Fiscal Year: 1999
    ..of the project is to identify a set of protective polypeptides that can be used to prevent ovarian infection in chickens, in order to interrupt transmission of this very important human pathogen to the human population by eggs and egg ..
  21. The evolution and spread of virulent infectious disease
    Wayne K Potts; Fiscal Year: 2013
    ..For example, the virulence of Marek's disease virus of chickens has been steadily increasing over the past decades as barriers to transmission and host genetic diversity have ..
  22. DOMINANT WHITE (I) GENE OF CHICKENS: MODEL FOR VITILIGO
    ROGER BOWERS; Fiscal Year: 1991
    ..aim of this research is to test the hypothesis that the dominant white gene white gene (I) expresses itself in WL chickens by making the feather and choroid melanocytes more sensitive to a cytotoxic agent, possibly a compound produced ..
  23. Molecular Regulation of Corneal Innervation
    JAMES KENNETH KUBILUS; Fiscal Year: 2013
    ..normal developmental innervation will be compared with reinnervation following refractive laser surgery (in adult chickens)...
  24. Adenovirus & Human Obesity - Longitudinal & Twin Studies
    Richard Atkinson; Fiscal Year: 2001
    ..and total body fat deposition, with paradoxically decreased serum cholesterol (CHOL) and triglycerides (TG), in chickens, mice, and monkeys...
  25. GENE CONVERSION IN MYC INDUCED BURSAL LYMPHOMAS
    Craig Thompson; Fiscal Year: 2001
    ..When chickens are infected in the perinatal period with avian leukosis (ALV), a retrovirus that does not contain a known ..
  26. Campylobacter jejuni proteins induced at 37C
    Stuart Thompson; Fiscal Year: 2007
    ..In its natural habitats, C. jejuni is able to thrive at two different temperatures, 42C (the core temperature of chickens) and 37C (in humans). Consequently, there is likely to be temperature regulation of C...
  27. POSSIBLE OF ROLE OF AVIAN RETROVIRUSES IN HUMAN CANCER
    Eric Johnson; Fiscal Year: 2002
    ..Humans are commonly exposed to avian leukosis/sarcoma viruses (ALSV) which naturally infect and cause cancer in chickens. ALSV can infect and transform human cells in vitro; and experimentally, primates can be infected and tumors ..
  28. ANIMAL MODELS OF VIRUS INDUCED OBESITY
    Richard Atkinson; Fiscal Year: 2000
    ..An avian adenovirus, SMAM-1, and a human adenovirus, AD-36, produce a syndrome of visceral obesity in chickens, with paradoxical decreased serum cholesterol and triglycerides...
  29. Role of Melanocyte Defect in Smyth Line Vitiligo
    Gisela Erf; Fiscal Year: 2001
    ..The mutant Smyth line chicken is an accepted animal model for autoimmune vitiligo. Chickens from this line develop a spontaneous, vitiligo-like, postnatal loss of melanin producing pigment cells (..
  30. MYOSIN ISOFORMS--FIBER TYPES AND THYROID REGULATION
    GARY RADICE; Fiscal Year: 1992
    ..Muscle determination and differentiation is being intensely studied in several vertebrates including rats, mice, chickens, and more recently, amphibians...
  31. In-ovo vaccination/avian influenza/bird/human
    DE CHU TANG; Fiscal Year: 2006
    ..mobilize the immune repertoire toward a beneficial immune protection against avian influenza virus infection in chickens. In this project, efficacy of a DMA vaccine will be compared to that induced by a non-replicating Ad vector ..
  32. ONCOGENIC ACTIVATION OF MYB FAMILY PROTEINS
    Joseph Lipsick; Fiscal Year: 2003
    ..discovered because the v-Myb oncogene of the avian myeloblastosis virus (AMV) causes a rapidly fatal leukemia in chickens. The v-Myb protein is a doubly truncated and mutated version of the normal c-Myb protein...
  33. ANTICOCCIDIAL DRUGS AND DRUG RESISTANCE IN TOXPLASMOSIS
    ELMER PFEFFERKORN; Fiscal Year: 1991
    ..These new drugs will be sought among the many anticoccidial agents that have been designed to treat infections of chickens with Eimeria species...
  34. Identification of factors controlling the genesis of cone photoreceptors
    Mark Emerson; Fiscal Year: 2009
    ..shows that Gnat2 and Gnb3 are both expressed specifically in the early photoreceptor layer in both mice and chickens as assayed by RNA in situ hybridizations...
  35. Analysis of Kinesins Mediating Neurotrophin Transport
    Rafal Butowt; Fiscal Year: 2006
    ..This work will utilize a particularly advantageous system the retinotectal pathway of embryonic chickens, because bulk anterograde transport as well as anterograde transport of specific neurotrophins can be easily ..
  36. Mechanisms of Bottom-up and Top-down Control of Spatial Attention
    ERIC KNUDSEN; Fiscal Year: 2013
    ..We have developed automated behavioral tasks that demonstrate both kinds of control of stimulus selection in chickens. In primates, a midbrain network is essential to competitive selection...
  37. Production of Polyclonal Antibodies in Eggs
    Marie Cecile van de Lavoir; Fiscal Year: 2003
    ..the applicant's abstract): Origen Therapeutics is committed to developing pharmaceutical products in transgenic chickens. In particular, Ongen's mission is to develop high affinity human antibodies...
  38. An expression system for protein production in eggs
    Lei Zhu; Fiscal Year: 2002
    ..expression vector for the ultimate goal of producing pharmaceutical proteins in eggs of transgenic chickens generated by embryonic stem (ES) cell-mediated transgenesis technology...
  39. VISION AND ETIOLOGY OF AXIAL MYOPIA
    JOSHUA WALLMAN; Fiscal Year: 2001
    ..of myopia, a leading cause of blindness, by studying the severe myopia produced by deprivation of form vision in chickens. This animal model has three important features: the visual deprivation of one part of the retina produces myopia ..
  40. RETROVIRUS-HOST INTERACTIONS
    Harriet Robinson; Fiscal Year: 1992
    ..vitro constructed recombinants of endogenous and exogenous avian leukosis viruses (ALVs) will be used in lines of chickens which have been bred for endogenous virus content to study the role of specific ALV sequences in tissue tropism, ..
  41. AUTOIMMUNE THYROIDITIS IN A MODEL
    Roy Sundick; Fiscal Year: 1990
    ..seeks to elucidate the genetic and environmental factors which contribute to the spontaneous thyroiditis of OS chickens and the iodide-induced thyroditis of CS chickens...
  42. COINCIDENCE DETECTION MODELS IN AUDITORY BRAINSTEM
    Jonathan Simon; Fiscal Year: 2003
    ..Understanding those mechanisms will substantially aid the quest for hearing aids and cochlear implants that would allow their users to localize sounds far better than current technology. ..
  43. OPTIMIZATION OF ANTIBODY PRODUCTION IN LAYING HENS
    Rosemary Schleicher; Fiscal Year: 1991
    ..There is no booster effect in chickens, and therefore there is less animal distress from repeated handling and injections...
  44. Antibodies Targeting Novel Surface Antigens on Pluripotent Stem Cell Derivatives
    David Larocca; Fiscal Year: 2009
    ..Antibodies will be raised in chickens because they are more likely to react to highly conserved antigens than mammalian hosts...
  45. GENE EXPRESSION IN MALARIA SPOROZOITES WITHIN THE VECTOR
    Brenda Beerntsen; Fiscal Year: 2001
    ..sporozoites of Plasmodium gallinaceum, whose life cycle oscillates between Anopheles mosquitoes and chickens. Differential screening of these two libraries was proposed, with the goal of identifying genes that would ..
  46. Mosquito-Virus-Host Interactions and WNV Pathogenesis
    Kristen Bernard; Fiscal Year: 2007
    ..Based on preliminary data that early viremia is 100-fold higher in chickens infected with WNV by mosquitoes compared to needle inoculation, the central hypothesis is that mosquito ..
  47. Entry of Coronaviruses into Host Cells
    GARY WHITTAKER; Fiscal Year: 2005
    ..In this application, we propose to use infectious bronchitis virus (IBV) of chickens as a model that would be directly applicable to highly pathogenic human coronaviruses, such as SARS-CoV...
  48. Regulation of Cutaneous Inflammation by local gd T Cells
    Robert Tigelaar; Fiscal Year: 2007
    In species as diverse as chickens, mice, and humans, substantial numbers of T cells are constitutively associated with body surface epithelia, such as the gut, genitourinary tract, and the skin...
  49. Identification of Novel Genes Expressed in Bowel Cancer Using Change Mediated Ant
    Jeffrey Hillman; Fiscal Year: 2007
    ..In Specific Aim 2, a CMAT IgY probe will be created by immunizing chickens with colorectal cancer tissue samples from subjects...
  50. Effects of Arsenic on Cytochromes P450
    RALPH NICHOLS; Fiscal Year: 2005
    ..We have found that, in primary cultures of hepatocytes from species as diverse as humans, rats and chickens, arsenite causes major decreases in the protein moieties of several CYPs, with little to no decrease in their ..
  51. RETINAL DEGENERATION: A NEW ANIMAL MODEL
    Paul Hargrave; Fiscal Year: 1991
    ..This model, the rd, or retinal degenerate strain of chickens, exhibits a recessive mode of genetic transmission of a defect that leads to blindness early in life...
  52. Post Synaptic Receptors Mediating Eighth Nerve Function
    SHUNDA IRONS BROWN; Fiscal Year: 2001
    ..The absence of effects at all doses will rule out a critical role for the respective receptor types in the generation of the ACAP and VCAP. ..
  53. Dietary Intervention in the Gallus Domesticus Model of Ovarian Cancer
    DALE HALES; Fiscal Year: 2009
    ..Aim 2) Determine if a broccoli supplemented vs. I3C supplemented diets prevent the development of ovarian cancer in chickens.
  54. Avian Influenza Virus Vaccines Bearing Immunomodulators
    Paul Roberts; Fiscal Year: 2007
    ..DESCRIPTION (provided by applicant): Avian influenza viruses pose a significant health threat for both humans and chickens in developing and developed countries...
  55. Post-translational modifications affect c-Myb specificity.
    Anita Quintana; Fiscal Year: 2009
    ..V-Myb is capable of causing acute myeloid leukemia (AMI) in chickens and can transform hematopoietic cells in vitro...
  56. PRODUCTION OF PHARMACEUTICAL PROTEINS IN EGGS
    Marie Cecile van de Lavoir; Fiscal Year: 2000
    ..research is to establish chicken embryonic stem cell cultures with the goal of developing genetically modified chickens that produce pharmaceutical proteins in their eggs...
  57. PROTO-ONCOGENES AND CELL CYCLE REGULATION IN DROSOPHILA
    Alisa Katzen; Fiscal Year: 2002
    ..activities should help to illuminate how the activated gene contributes to the genesis of neoplastic disease in chickens, mice, and humans...
  58. An expression system for protein production in eggs
    Lei Zhu; Fiscal Year: 2004
    ..for the ultimate goal of producing pharmaceutical proteins including monoclonal antibodies in eggs of transgenic chickens using Origen Theapeutics' technology...
  59. RHESUS ES CELLS: A MODEL TO STUDY PANCREAS DEVELOPMENT
    Jon Odorico; Fiscal Year: 2001
    ..insights to the mechanisms of pancreatic organogenesis have been gained through recent experiments in mice and chickens. However, critical differences in early developmental pathways between these species and humans places the direct ..
  60. REGULATION OF HDL SYNTHESIS AND SECRETION
    Debendranath Banerjee; Fiscal Year: 1991
    ..Our in vivo studies with chickens characterized nascent intracellular HDL particles, showed that lipid-protein assembly occurs mostly in the Golgi ..
  61. NA-K ATPASE ISOFORMS--FUNCTION AND LOCALIZATION
    Michael Tamkun; Fiscal Year: 1992
    ..that a family of genes is responsible for different isoforms of the ATPase alpha subunit in species as diverse as chickens, rodents, and man. Only one isoform of the beta subunit has been identified in any species...
  62. Trans acting function of the v and c Rel oncoproteins
    Celine Gelinas; Fiscal Year: 2005
    ..retrovirus reticuloendotheliosis virus strain T (Rev-T) induces aggressive and fatal leukemia/lymphoma in chickens and transgenic mice...
  63. Gene Regulation by Myb Proteins
    Joseph Lipsick; Fiscal Year: 2005
    DESCRIPTION (PROVIDE BY APPLICANT): The v-Myb oncogene causes acute monoblastic leukemia in chickens and induces the leukemic transformation of myelomonocytic cells in culture...
  64. IN VITRO MUTAGENESIS OF HISTONE AND HMG GENES
    Jerry Dodgson; Fiscal Year: 1993
    ..My lab has isolated genomic and cDNA clones coding for several such proteins of chickens. these clones will be used to prepare a variety of specific mutated chromosomal protein genes...