probiotics

Summary

Summary: Live microbial DIETARY SUPPLEMENTS which beneficially affect the host animal by improving its intestinal microbial balance. Antibiotics and other related compounds are not included in this definition. In humans, lactobacilli are commonly used as probiotics, either as single species or in mixed culture with other bacteria. Other genera that have been used are bifidobacteria and streptococci. (J. Nutr. 1995;125:1401-12)

Top Publications

  1. ncbi Gut flora in health and disease
    Francisco Guarner
    Digestive System Research Unit, Hospital General Vall d Hebron, Barcelona, Spain
    Lancet 361:512-9. 2003
  2. pmc Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
    Harry Sokol
    Unité Ecologie et Physiologie du Système Digestif, Institut National de la Recherche Agronomique U910, Domaine de Vilvert, 78350 Jouy en Josas, France
    Proc Natl Acad Sci U S A 105:16731-6. 2008
  3. pmc Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability
    P D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    Gut 58:1091-103. 2009
  4. pmc Microbes in gastrointestinal health and disease
    Andrew S Neish
    Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Gastroenterology 136:65-80. 2009
  5. ncbi Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens
    Sarah Lebeer
    Centre of Microbial and Plant Genetics, K U Leuven, Kasteelpark Arenberg 20, Bus 2460, B 3001 Leuven, Belgium
    Nat Rev Microbiol 8:171-84. 2010
  6. ncbi Probiotics, prebiotics, and synbiotics: impact on the gut immune system and allergic reactions
    Pascal Gourbeyre
    INRA, UR1268, Unite de recherche sur les Biopolyme res, leurs Interactions et Assemblages, Nantes, France
    J Leukoc Biol 89:685-95. 2011
  7. ncbi Targeting gut microbiota in obesity: effects of prebiotics and probiotics
    Nathalie M Delzenne
    Universite Catholique de Louvain, Brussels, Belgium nathalie delzenne uclouvain be
    Nat Rev Endocrinol 7:639-46. 2011
  8. pmc Targeting the human microbiome with antibiotics, probiotics, and prebiotics: gastroenterology enters the metagenomics era
    Geoffrey A Preidis
    Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas, USA
    Gastroenterology 136:2015-31. 2009
  9. ncbi The extracellular biology of the lactobacilli
    Michiel Kleerebezem
    TI Food and Nutrition, Wageningen, The Netherlands
    FEMS Microbiol Rev 34:199-230. 2010
  10. ncbi Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial
    M Kalliomaki
    Department of Paediatrics, University of Turku and Turku University Hospital, Finland
    Lancet 357:1076-9. 2001

Detail Information

Publications358 found, 100 shown here

  1. ncbi Gut flora in health and disease
    Francisco Guarner
    Digestive System Research Unit, Hospital General Vall d Hebron, Barcelona, Spain
    Lancet 361:512-9. 2003
    ..Nevertheless, bacteria are also useful in promotion of human health. Probiotics and prebiotics are known to have a role in prevention or treatment of some diseases.
  2. pmc Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
    Harry Sokol
    Unité Ecologie et Physiologie du Système Digestif, Institut National de la Recherche Agronomique U910, Domaine de Vilvert, 78350 Jouy en Josas, France
    Proc Natl Acad Sci U S A 105:16731-6. 2008
    ..These results suggest that counterbalancing dysbiosis using F. prausnitzii as a probiotic is a promising strategy in CD treatment...
  3. pmc Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability
    P D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    Gut 58:1091-103. 2009
    ....
  4. pmc Microbes in gastrointestinal health and disease
    Andrew S Neish
    Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Gastroenterology 136:65-80. 2009
    ....
  5. ncbi Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens
    Sarah Lebeer
    Centre of Microbial and Plant Genetics, K U Leuven, Kasteelpark Arenberg 20, Bus 2460, B 3001 Leuven, Belgium
    Nat Rev Microbiol 8:171-84. 2010
    ..Distinctions and parallels are therefore drawn with the interactions of similar molecules that are presented by gastrointestinal commensals and pathogens...
  6. ncbi Probiotics, prebiotics, and synbiotics: impact on the gut immune system and allergic reactions
    Pascal Gourbeyre
    INRA, UR1268, Unite de recherche sur les Biopolyme res, leurs Interactions et Assemblages, Nantes, France
    J Leukoc Biol 89:685-95. 2011
    b>Probiotics and prebiotics, alone or together (synbiotics), can influence the intestinal microbiota and modulate the immune response...
  7. ncbi Targeting gut microbiota in obesity: effects of prebiotics and probiotics
    Nathalie M Delzenne
    Universite Catholique de Louvain, Brussels, Belgium nathalie delzenne uclouvain be
    Nat Rev Endocrinol 7:639-46. 2011
    ..The gut microbiota is, therefore, a potential nutritional and pharmacological target in the management of obesity and obesity-related disorders...
  8. pmc Targeting the human microbiome with antibiotics, probiotics, and prebiotics: gastroenterology enters the metagenomics era
    Geoffrey A Preidis
    Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas, USA
    Gastroenterology 136:2015-31. 2009
    ..by the ability to modify the gastrointestinal microbiota through the rational deployment of antibiotics, probiotics, and prebiotics. Antibiotics might be used to remove or suppress undesirable components of the human microbiome...
  9. ncbi The extracellular biology of the lactobacilli
    Michiel Kleerebezem
    TI Food and Nutrition, Wageningen, The Netherlands
    FEMS Microbiol Rev 34:199-230. 2010
    ..fermentation processes, specific strains of Lactobacillus are currently marketed as health-promoting cultures or probiotics. The last decade has witnessed the completion of a large number of Lactobacillus genome sequences, including the ..
  10. ncbi Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial
    M Kalliomaki
    Department of Paediatrics, University of Turku and Turku University Hospital, Finland
    Lancet 357:1076-9. 2001
    ..In the hygiene hypothesis this increase is attributed to reduced microbial exposure in early life. Probiotics are cultures of potentially beneficial bacteria of the healthy gut microflora...
  11. pmc Genes and molecules of lactobacilli supporting probiotic action
    Sarah Lebeer
    Centre of Microbial and Plant Genetics, K U Leuven, Kasteelpark Arenberg 20, 3001 Leuven, Belgium
    Microbiol Mol Biol Rev 72:728-64, Table of Contents. 2008
    ..studies resulted in positive outcomes, scientific interest arose regarding the precise mechanisms of action of probiotics. Many reported mechanistic studies have addressed mainly the host responses, with less attention being focused ..
  12. pmc Characterization of the SpaCBA pilus fibers in the probiotic Lactobacillus rhamnosus GG
    Justus Reunanen
    Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland
    Appl Environ Microbiol 78:2337-44. 2012
    ..rhamnosus GG compared to that of nonpiliated lactobacilli...
  13. pmc Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth
    Fang Yan
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Gastroenterology 132:562-75. 2007
    ..Here, we purify and characterize 2 secreted LGG proteins that regulate intestinal epithelial cell antiapoptotic and proliferation responses...
  14. pmc Comparative genomic and functional analysis of Lactobacillus casei and Lactobacillus rhamnosus strains marketed as probiotics
    Francois P Douillard
    Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland
    Appl Environ Microbiol 79:1923-33. 2013
    ..rhamnosus GG and further highlights the differences between these and L. casei strains widely marketed as probiotics, in terms of genome content, mucus-binding and metabolic capacities, and host signaling capabilities.
  15. ncbi Mitigating amphibian chytridiomycosis with bioaugmentation: characteristics of effective probiotics and strategies for their selection and use
    Molly C Bletz
    Department of Biology, James Madison University, Harrisonburg, VA, USA
    Ecol Lett 16:807-20. 2013
    ..the current research in amphibian microbial ecology and bioaugmentation to identify characteristics of effective probiotics in relation to their interactions with Bd, their host, other resident microbes and the environment...
  16. ncbi Meta-analysis: the effect of supplementation with probiotics on eradication rates and adverse events during Helicobacter pylori eradication therapy
    J L Tong
    Department of Gastroenterology, Shanghai Institute of Digestive Disease, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China
    Aliment Pharmacol Ther 25:155-68. 2007
    Recent evidence found probiotics could inhibit Helicobacter pylori colonization from both in vitro and in vivo studies.
  17. ncbi Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis
    Qing Liu
    Artificial Liver Treatment and Training Center, Beijing Youan Hospital and Capital University of Medical Sciences, Beijing, China
    Hepatology 39:1441-9. 2004
    ..Treatment with lactulose is of benefit. The possible role of synbiotics (probiotics and fermentable fiber) has not been assessed...
  18. pmc Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism
    Fang Yan
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Monroe Carell Jr Children s Hospital at Vanderbilt, Nashville, Tennessee 37232 0696, USA
    J Clin Invest 121:2242-53. 2011
    ..These data define what we believe to be a previously unrecognized mechanism of probiotic-derived soluble proteins in protecting the intestine from injury and inflammation...
  19. pmc Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells
    Xiong Ma
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    J Hepatol 49:821-30. 2008
    ..In the current study, we evaluated the effect of probiotics, and their mechanisms on diet-induced obesity, steatosis and insulin resistance.
  20. ncbi Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin
    Hermelijn H Smits
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Allergy Clin Immunol 115:1260-7. 2005
    ..It is hypothesized that these probiotics have immunoregulatory properties and promote mucosal tolerance, which is in part mediated by regulatory T cells (..
  21. ncbi Recommendations for probiotic use-2011 update
    Martin H Floch
    Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT 06150, USA
    J Clin Gastroenterol 45:S168-71. 2011
    ..Recommendations for the use of probiotics in necrotizing enterocolitis, childhood diarrhea, inflammatory bowel disease, irritable bowel syndrome, and ..
  22. pmc Dose-dependent immunomodulation of human dendritic cells by the probiotic Lactobacillus rhamnosus Lcr35
    Bertrand Evrard
    CHU Clermont Ferrand, Laboratoire d Immunologie, Clermont Ferrand, France
    PLoS ONE 6:e18735. 2011
    The response of the immune system to probiotics remains controversial...
  23. ncbi Probiotic mechanisms of action
    Miriam Bermudez-Brito
    Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology José Mataix, Biomedical Research Center, University of Granada, Armilla, Spain
    Ann Nutr Metab 61:160-74. 2012
    b>Probiotics are live microorganisms that provide health benefits to the host when ingested in adequate amounts. The strains most frequently used as probiotics include lactic acid bacteria and bifidobacteria...
  24. ncbi The utility of probiotics in the treatment of irritable bowel syndrome: a systematic review
    Darren M Brenner
    Division of Gastroenterology, Department of Internal Medicine, Northwestern University Feinberg School of Medicine, Ann Arbor, Michigan, USA
    Am J Gastroenterol 104:1033-49; quiz 1050. 2009
    ..in gut microflora may contribute to the development of IBS symptoms, and researchers have hypothesized that probiotics might improve these symptoms...
  25. pmc Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine
    W Kruis
    Evangelisches Krankenhaus Kalk, University of Cologne, Germany
    Gut 53:1617-23. 2004
    Evidence exists for the pathogenic role of the enteric flora in inflammatory bowel disease. Probiotics contain living microorganisms which exert health effects on the host...
  26. ncbi Genome-scale analyses of health-promoting bacteria: probiogenomics
    Marco Ventura
    Department of Genetics, Anthropology and Evolution, University of Parma, Italy
    Nat Rev Microbiol 7:61-71. 2009
    ..In this Review, we discuss the application of probiogenomics in the elucidation of the molecular basis of probiosis using the well-recognized model probiotic bacteria genera Bifidobacterium and Lactobacillus as examples...
  27. ncbi A differential effect of 2 probiotics in the prevention of eczema and atopy: a double-blind, randomized, placebo-controlled trial
    Kristin Wickens
    Wellington Asthma Research Group, Wellington School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand
    J Allergy Clin Immunol 122:788-94. 2008
    The role of probiotics in prevention of allergic disease is still not clearly established, although early reports suggested Lactobacillus GG halved the risk of eczema at 2 years.
  28. ncbi Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles
    Liam O'Mahony
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Gastroenterology 128:541-51. 2005
    ..The aim of this study was to compare the response of symptoms and cytokine ratios in irritable bowel syndrome (IBS) with ingestion of probiotic preparations containing a lactobacillus or bifidobacterium strain...
  29. pmc Modulation of human dendritic cell phenotype and function by probiotic bacteria
    A L Hart
    Antigen Presentation Research Group, Faculty of Medicine Imperial College London, Northwick Park Campus, Watford Road, Harrow, Middlesex HA1 3UJ, UK
    Gut 53:1602-9. 2004
    ..Dendritic cells, which are pivotal in early bacterial recognition, tolerance induction, and shaping of T cell responses, may be central in mediating the effects of these bacteria...
  30. ncbi Probiotics and the gut microbiota in intestinal health and disease
    Mélanie G Gareau
    Cell Biology Program, Research Institute, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Nat Rev Gastroenterol Hepatol 7:503-14. 2010
    The use of probiotics is increasing in popularity for both the prevention and treatment of a variety of diseases...
  31. pmc Bile salt hydrolase activity in probiotics
    Maire Begley
    Department of Microbiology, University College Cork, College Road, Cork, Ireland
    Appl Environ Microbiol 72:1729-38. 2006
  32. ncbi Human milk is a source of lactic acid bacteria for the infant gut
    Rocio Martin
    Departament of Nutrición y Bromatología III, Universidad Complutense de Madrid, Madrid, Spain
    J Pediatr 143:754-8. 2003
    ....
  33. pmc Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders
    Ho Keun Kwon
    Department of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Korea
    Proc Natl Acad Sci U S A 107:2159-64. 2010
    The beneficial effects of probiotics have been described in many diseases, but the mechanism by which they modulate the immune system is poorly understood...
  34. ncbi The efficacy of probiotics in the treatment of irritable bowel syndrome: a systematic review
    P Moayyedi
    Department of Medicine, Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, HSC 4W8E, Hamilton, ON L8N 3Z5, Canada
    Gut 59:325-32. 2010
    b>Probiotics may benefit irritable bowel syndrome (IBS) symptoms, but randomised controlled trials (RCTs) have been conflicting; therefore a systematic review was conducted.
  35. ncbi Probiotic dietary supplementation in patients with stage 3 and 4 chronic kidney disease: a 6-month pilot scale trial in Canada
    Natarajan Ranganathan
    Kibow Biotech, Inc, Newtown Square, PA 19073, USA
    Curr Med Res Opin 25:1919-30. 2009
    ..This was a pilot clinical trial to assess biochemical and clinical effects of an oral probiotic dietary supplement in chronic kidney disease (CKD) patients (stages 3 and 4)...
  36. ncbi Do nutrient-gut-microbiota interactions play a role in human obesity, insulin resistance and type 2 diabetes?
    M Diamant
    Diabetes Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Obes Rev 12:272-81. 2011
    ..Large-scale intervention trials, investigating the potential benefit of prebiotics and probiotics in improving cardiometabolic health in high-risk populations, are eagerly awaited.
  37. ncbi Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics
    R Balfour Sartor
    Department of Medicine, Microbiology and Immunology, Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina 27599 7032 USA
    Gastroenterology 126:1620-33. 2004
    ..Alternatively, administration of beneficial bacterial species (probiotics), poorly absorbed dietary oligosaccharides (prebiotics), or combined probiotics and prebiotics (synbiotics) can ..
  38. ncbi Beneficial effect of oral administration of Lactobacillus casei strain Shirota on insulin resistance in diet-induced obesity mice
    E Naito
    Yakult Central Institute for Microbiological Research, Kunitachi shi, Tokyo, Japan
    J Appl Microbiol 110:650-7. 2011
    ....
  39. ncbi Clinical trial: the effects of a fermented milk product containing Bifidobacterium lactis DN-173 010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipation
    A Agrawal
    Neurogastroenterology Unit, Translational Medicine GI Sciences, University of Manchester, UK
    Aliment Pharmacol Ther 29:104-14. 2009
    ..A sensation of abdominal swelling (bloating) and actual increase in girth (distension) are troublesome features of irritable bowel syndrome (IBS), which is more common in patients with constipation, especially those with delayed transit...
  40. pmc Lactobacillus adhesion to mucus
    Maxwell L Van Tassell
    Department of Food Science and Human Nutrition, University of Illinois, 905 S Goodwin Ave, Urbana, IL 61801, USA
    Nutrients 3:613-36. 2011
    ..Understanding the nature of mucus-microbe interactions could be the key to elucidating the mechanisms of probiotic adhesion within the host...
  41. ncbi Towards a better understanding of the use of probiotics for preventing chytridiomycosis in Panamanian golden frogs
    Matthew H Becker
    Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061, USA
    Ecohealth 8:501-6. 2011
    ..At this point, frogs began to die of chytridiomycosis. Future research will concentrate on isolating and testing antifungal bacterial species from Panama that may be more compatible with Atelopus skin...
  42. ncbi Taxonomy of Lactobacilli and Bifidobacteria
    Giovanna E Felis
    Dipartimento Scientifico e Tecnologico, Facolta di Scienze MM FF NN, Universita degli Studi di Verona, Strada Le Grazie 15, 37134 Verona, Italy
    Curr Issues Intest Microbiol 8:44-61. 2007
    ..of species and strains exhibiting important properties in an applied context, especially in the area of food and probiotics. An updated list of species belonging to those two genera, their phylogenetic relationships and other relevant ..
  43. ncbi Probiotics for the prevention and treatment of antibiotic-associated diarrhea: a systematic review and meta-analysis
    Susanne Hempel
    Southern California Evidence Based Practice Center, RAND Health, 1776 Main St, Santa Monica, CA 90401, USA
    JAMA 307:1959-69. 2012
    b>Probiotics are live microorganisms intended to confer a health benefit when consumed. One condition for which probiotics have been advocated is the diarrhea that is a common adverse effect of antibiotic use.
  44. ncbi The immunomodulatory effects of lactic acid bacteria for improving immune functions and benefits
    Yueh Ting Tsai
    Department of Biochemical Science and Technology, College of Life Science, National Taiwan University, Number 1, Section 4, Roosevelt Road, Taipei 10617, Taiwan
    Appl Microbiol Biotechnol 96:853-62. 2012
    b>Probiotics have a number of beneficial health effects in humans and animals, such as reducing lactose intolerance symptoms and enhancing the bioavailability of nutrients...
  45. pmc L. plantarum, L. salivarius, and L. lactis attenuate Th2 responses and increase Treg frequencies in healthy mice in a strain dependent manner
    Maaike J Smelt
    Top Institute Food and Nutrition, Wageningen, The Netherlands
    PLoS ONE 7:e47244. 2012
    Many studies on probiotics are aimed at restoring immune homeostasis in patients to prevent disease recurrence or reduce immune-mediated pathology...
  46. pmc Detection of Lactobacillus, Pediococcus, Leuconostoc, and Weissella species in human feces by using group-specific PCR primers and denaturing gradient gel electrophoresis
    J Walter
    Institute of Food Technology, University of Hohenheim, Stuttgart, Germany
    Appl Environ Microbiol 67:2578-85. 2001
    ..rhamnosus was detectable by PCR-DGGE during the test period in the feces of both subjects, whereas it was detectable by culture in only one of the subjects...
  47. pmc Screening of probiotic activities of forty-seven strains of Lactobacillus spp. by in vitro techniques and evaluation of the colonization ability of five selected strains in humans
    C N Jacobsen
    Department of Dairy and Food Science, Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Appl Environ Microbiol 65:4949-56. 1999
    ..The bacteria were reisolated in concentrations from 10(5) to 10(8) cells/g of feces. Survival and reisolation of the bacteria in vivo appeared to be linked to pH tolerance, adhesion, and antimicrobial properties in vitro...
  48. ncbi Protective action of Lactobacillus kefir carrying S-layer protein against Salmonella enterica serovar Enteritidis
    M A Golowczyc
    Centro de Investigación y Desarrollo en Criotecnología de Alimentos CIDCA, Argentina
    Int J Food Microbiol 118:264-73. 2007
    ..kefir strains were unable to invade Caco-2/TC-7 cells. After treatment, L. kefir S-layer protein was detected associated with Salmonella, suggesting a protective role of this protein on association and invasion...
  49. ncbi Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children
    Joshua Z Goldenberg
    Bastyr University, Seattle, WA, USA
    Cochrane Database Syst Rev 5:CD006095. 2013
    ..difficile). Probiotics are live organisms thought to balance the gastrointestinal flora.
  50. ncbi Probiotics and their fermented food products are beneficial for health
    S Parvez
    Helix Pharms Co Ltd, Kyung Hee University, and Department of Biological Sciences of Oriental Medicine, Graduate School of Interdepartmental Studies, Institute of Oriental Medicines, Kyung Hee University, Dongdaemoon gu, Seoul, Korea
    J Appl Microbiol 100:1171-85. 2006
    b>Probiotics are usually defined as microbial food supplements with beneficial effects on the consumers...
  51. ncbi Probiotic lactic acid bacteria in the gastro-intestinal tract: health benefits, safety and mode of action
    L M T Dicks
    Department of Microbiology, University of Stellenbosch, South Africa
    Benef Microbes 1:11-29. 2010
    Lactic acid bacteria (LAB) have received considerable attention as probiotics over the past few years. This concept has grown from traditional dairy products to a profitable market of probiotic health supplements and functional foods...
  52. ncbi VSL#3 probiotics exerts the anti-inflammatory activity via PI3k/Akt and NF-κB pathway in rat model of DSS-induced colitis
    Cong Dai
    Department of Cadre Ward V, First Affiliated Hospital, China Medical University, Shenyang City, Liaoning Province, China
    Mol Cell Biochem 374:1-11. 2013
    VSL#3 probiotics can be effective on induction and maintenance of the remission of clinical ulcerative colitis. However, the mechanisms are not fully understood...
  53. ncbi The VSL#3 probiotic formula induces mucin gene expression and secretion in colonic epithelial cells
    C Caballero-Franco
    Institute of Parasitology, McGill University, Saint Anne de Bellevue, Quebec, Canada
    Am J Physiol Gastrointest Liver Physiol 292:G315-22. 2007
    ..This raises the possibility that probiotics may play an active role in enhancing the intestinal barrier at the mucosal surface...
  54. ncbi The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus
    R S Kootte
    Department of Vascular Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Diabetes Obes Metab 14:112-20. 2012
    ..The influence of short-chain fatty acids, bile acids, prebiotics, probiotics, antibiotics and microbial transplantation is discussed from studies using animal and human models...
  55. ncbi VSL#3 improves symptoms in children with irritable bowel syndrome: a multicenter, randomized, placebo-controlled, double-blind, crossover study
    Stefano Guandalini
    University of Chicago Section of Pediatric Gastroenterology, Hepatology and Nutrition, Chicago, IL, USA
    J Pediatr Gastroenterol Nutr 51:24-30. 2010
    ..b>Probiotics have shown some promising results in adult studies, but no positive study has been published on pediatric age...
  56. ncbi An intimate tête-à-tête - how probiotic lactobacilli communicate with the host
    Daniela M Remus
    TI Food and Nutrition, Nieuwe Kanaal 9A, 6709 PA Wageningen, The Netherlands
    Eur J Pharmacol 668:S33-42. 2011
    ..In contrast, the understanding of the molecular mechanisms, which determine the role of probiotics, i.e. health-promoting bacteria, as host cell modulators is still in its infancy...
  57. pmc Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation
    Andrea Mencarelli
    Dipartimento di Medicina Clinica e Sperimentale, University of Perugia, Facolta di Medicina e Chirurgia, Via Gerardo Dottori n 1 S Andrea delle Fratte, Perugia, Italy
    PLoS ONE 6:e22978. 2011
    ....
  58. ncbi Probiotics: potential to prevent HIV and sexually transmitted infections in women
    Michael Bolton
    Department of Medicine, Emory University, Atlanta, Georgia, USA
    Sex Transm Dis 35:214-25. 2008
    ..If results from such a trial demonstrate efficacy, future studies should be designed to determine whether a probiotic can significantly lower the risk for HIV and STIs in at-risk female populations...
  59. ncbi Probiotics and lung diseases
    Paul Forsythe
    Brain Body Institute and Department of Medicine, McMaster University, Hamilton, ON, Canada
    Chest 139:901-8. 2011
    ..in the development and modulation of the immune system has led to great interest in the therapeutic potential of probiotics and other bacteria-based strategies for a range of immune-related disorders...
  60. pmc Identification of Lactobacillus plantarum genes modulating the cytokine response of human peripheral blood mononuclear cells
    Saskia van Hemert
    TI Food and Nutrition, Nieuwe Kanaal 9A, 6709PA, Wageningen, The Netherlands
    BMC Microbiol 10:293. 2010
    ..plantarum with the potential to influence the amounts of cytokines interleukin 10 (IL-10) and IL-12 and the ratio of IL-10/IL-12 produced by peripheral blood mononuclear cells (PBMCs)...
  61. pmc Probiotic Lactobacillus reuteri biofilms produce antimicrobial and anti-inflammatory factors
    Sara E Jones
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    BMC Microbiol 9:35. 2009
    ....
  62. ncbi Efficacy of Lactobacillus GG in maintaining remission of ulcerative colitis
    M A Zocco
    Department of Internal Medicine, Catholic University of Rome, Rome, Italy
    Aliment Pharmacol Ther 23:1567-74. 2006
    Aminosalicylates are the mainstay of therapy to prevent relapse of quiescent ulcerative colitis. The rationale for using probiotics is based on the evidence implicating intestinal bacteria in the pathogenesis of this disorder.
  63. ncbi Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial
    Marc G H Besselink
    Department of Surgery, University Medical Center Utrecht, Utrecht, Netherlands
    Lancet 371:651-9. 2008
    ..Enteral administration of probiotics could prevent infectious complications, but convincing evidence is scarce...
  64. ncbi Adhesion of probiotic strains to the intestinal mucosa and interaction with pathogens
    Alain L Servin
    Institut National de la Sante et de la Recherche Medicale, Unité 510, Pathogénes et Fonctions des Cellules Epithéliales Polarisées, Faculte de Pharmacie Paris XI, Châtenay Malabry 92296, France
    Best Pract Res Clin Gastroenterol 17:741-54. 2003
    ..The objective of this review is to analyse the in vitro or in vivo experimental studies in which the antimicrobial activity of selected Lactobacillus and Bifidobacterium strains has been documented...
  65. ncbi Human originated bacteria, Lactobacillus rhamnosus PL60, produce conjugated linoleic acid and show anti-obesity effects in diet-induced obese mice
    Hui Young Lee
    Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 151 742, Korea
    Biochim Biophys Acta 1761:736-44. 2006
    ..rhamnosus PL60 treatment; on the contrary it seemed to be normalized. Results showed that the amount of conjugated linoleic acid produced by Lactobacillus rhamnosus PL60 was enough to produce an anti-obesity effect...
  66. ncbi Probiotics, prebiotics, and synbiotics--approaching a definition
    J Schrezenmeir
    Institute of Physiology and Biochemistry of Nutrition, Federal Dairy Research Center, Kiel, Germany
    Am J Clin Nutr 73:361S-364S. 2001
    ..It therefore may include sites such as the oral cavity, the intestine, the vagina, and the skin...
  67. ncbi Bioproduction of conjugated linoleic acid by probiotic bacteria occurs in vitro and in vivo in mice
    Julia B Ewaschuk
    Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada
    J Nutr 136:1483-7. 2006
    b>Probiotics have been shown to reduce the incidence of colon cancer in animal models. The mechanisms responsible for this activity are poorly defined...
  68. ncbi Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease
    Zhiping Li
    The Johns Hopkins University, Baltimore, MD 21205, USA
    Hepatology 37:343-50. 2003
    ..In conclusion, these results support the concept that intestinal bacteria induce endogenous signals that play a pathogenic role in hepatic insulin resistance and NAFLD and suggest novel therapies for these common conditions...
  69. ncbi Bifidobacterium infantis 35624 administration induces Foxp3 T regulatory cells in human peripheral blood: potential role for myeloid and plasmacytoid dendritic cells
    Patrycja Konieczna
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Zurich, Switzerland
    Gut 61:354-66. 2012
    ..Intestinal homoeostasis is dependent on immunological tolerance to the microbiota...
  70. ncbi Emerging molecular insights into the interaction between probiotics and the host intestinal mucosa
    Peter A Bron
    Top Institute Food and Nutrition, Nieuwe Kanaal 9A, 6709 PA Wageningen, The Netherlands
    Nat Rev Microbiol 10:66-78. 2012
    ..Furthermore, nutrigenomic analyses of the response to probiotics have unravelled the signalling and immune response pathways which are modulated by probiotic bacteria...
  71. pmc Potential uses of probiotics in clinical practice
    Gregor Reid
    Canadian Research and Development Centre for Probiotics, The Lawson Health Research Institute, London, Ontario N6A 4V2, Canada
    Clin Microbiol Rev 16:658-72. 2003
    b>Probiotics are defined as live microorganisms that, when administered in adequate amounts, confer a health benefit on the host...
  72. ncbi Bacillus probiotics
    Simon M Cutting
    School of Biological Sciences, Royal Holloway University of London, Egham, Surrey TW20 0EX, UK
    Food Microbiol 28:214-20. 2011
    ..This review summarises the current use of Bacillus species as probiotics, their safety, mode of action as well as their commercial applications.
  73. ncbi Probiotic-induced suppression of allergic sensitization and airway inflammation is associated with an increase of T regulatory-dependent mechanisms in a murine model of asthma
    W Feleszko
    Department of Pediatric Pneumology and Allergy, The Medical University Children s Hospital, Warszawa, Poland
    Clin Exp Allergy 37:498-505. 2007
    ..Application of non-pathogenic probiotic bacteria during early infancy might protect from allergic disorders but underlying mechanisms have not been analysed so far...
  74. ncbi Molecular mechanisms underlying the probiotic effects of Escherichia coli Nissle 1917 involve ZO-2 and PKCzeta redistribution resulting in tight junction and epithelial barrier repair
    Agata A Zyrek
    Institut für Infektiologie, Zentrum für Molekularbiologie der Entzündung ZMBE, Westfälische Wilhelms Universität Universitätsklinikum Münster, Von Esmarch Str 56, D 48149 Munster, Germany
    Cell Microbiol 9:804-16. 2007
    ..We suggest that these properties contribute to the reported efficacy in the treatment of inflammatory bowel diseases and in part rationalize the probiotic nature of EcN...
  75. ncbi Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial
    Y Kadooka
    Technology and Research Institute, Snow Brand Milk Products Co Ltd, Kawagoe, Saitama, Japan
    Eur J Clin Nutr 64:636-43. 2010
    In spite of the much evidence for the beneficial effects of probiotics, their anti-obesity effects have not been well examined...
  76. pmc Probiotic bacteria induce a 'glow of health'
    Tatiana Levkovich
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 8:e53867. 2013
    ..Aged male animals eating probiotics exhibited increased subcuticular folliculogenesis, when compared with matched controls, yielding luxuriant fur ..
  77. ncbi Selection of potential probiotic lactobacilli for cholesterol-lowering properties and their effect on cholesterol metabolism in rats fed a high-lipid diet
    J Wang
    The Key Laboratory of Dairy Biotechnology and Bioengineering, Education Ministry of PR China, Department of Food Science and Engineering, Inner Mongolia Agricultural University, Huhhot 010018, PR China
    J Dairy Sci 95:1645-54. 2012
    ..The mechanisms behind the hypocholesterolemic effect of 3 strains are likely to be diverse and will need further investigation...
  78. pmc Differential Toll-like receptor recognition and induction of cytokine profile by Bifidobacterium breve and Lactobacillus strains of probiotics
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
    Clin Vaccine Immunol 18:621-8. 2011
    The use of probiotics as a food supplement has gained tremendous interest in the last few years as beneficial effects were reported in gut homeostasis and nutrient absorption but also in immunocompromised patients, supporting protection ..
  79. pmc Cytokine profile and induction of T helper type 17 and regulatory T cells by human peripheral mononuclear cells after microbial exposure
    O N Donkor
    School of Biomedical and Health Sciences, Victoria University, Werribee Campus, Werribee, Vic, Australia
    Clin Exp Immunol 167:282-95. 2012
    The immunomodulatory effects of probiotics were assessed following exposure of normal peripheral blood mononuclear cells (PBMC), cord blood cells and the spleen-derived monocyte/macrophage cell line CRL-9850 to Lactobacillus acidophilus ..
  80. pmc Gut microbiota, probiotics, and vitamin D: interrelated exposures influencing allergy, asthma, and obesity?
    Ngoc P Ly
    Division of Pediatric Pulmonary Medicine, Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA
    J Allergy Clin Immunol 127:1087-94; quiz 1095-6. 2011
    ..The emergence of promising experimental studies has led to several clinical trials of probiotics (live bacteria given orally that allow for intestinal colonization) in human subjects...
  81. ncbi Lactobacillus reuteri-induced regulatory T cells protect against an allergic airway response in mice
    Khalil Karimi
    The Brain Body Institute, St Joseph s Healthcare, 50 Charlton Avenue East, T3312, Hamilton, ON L8N 4A6, Canada
    Am J Respir Crit Care Med 179:186-93. 2009
    ..However, the mechanisms underlying these effects remain to be determined...
  82. pmc Characterization of a probiotic-derived soluble protein which reveals a mechanism of preventive and treatment effects of probiotics on intestinal inflammatory diseases
    Fang Yan
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University School of Medicine and the Monroe Carell Jr Children s Hospital at Vanderbilt, Nashville, TN, USA
    Gut Microbes 3:25-8. 2012
    The beneficial effects of probiotics have been demonstrated in many diseases, such as inflammatory bowel disease...
  83. ncbi Interaction of orally administered Lactobacillus rhamnosus GG with skin and gut microbiota and humoral immunity in infants with atopic dermatitis
    M Nermes
    Department of Pediatrics, Turku University Central Hospital, Turku, Finland
    Clin Exp Allergy 41:370-7. 2011
    ..The maturational events in the gut parallel its step-wise colonization. Atopic dermatitis (AD) is associated with aberrant barrier functions of the skin epithelium and, in a subgroup of patients, of the gut mucosa...
  84. pmc Influence of probiotic Lactobacilli colonization on neonatal B cell responses in a gnotobiotic pig model of human rotavirus infection and disease
    Wei Zhang
    Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH 44691 4096, USA
    Vet Immunol Immunopathol 122:175-81. 2008
    ..LAB colonization alone is not as efficient in promoting intestinal B cell responses, as is HRV infection...
  85. ncbi Probiotic supplement reduces risk of necrotizing enterocolitis and mortality in preterm very low-birth-weight infants: an updated meta-analysis of 20 randomized, controlled trials
    Quanzhen Wang
    Department of Pediatrics, People s Hospital of Xiangtan County, Xiangtan County 411200, Hunan Province, China
    J Pediatr Surg 47:241-8. 2012
    ..We performed an updated meta-analysis of all relevant randomized, controlled trials to assess the benefits of probiotic supplementation for preterm very low-birth-weight (VLBW) infants...
  86. ncbi Effectiveness and safety of Saccharomyces boulardii for acute infectious diarrhea
    Ener Cagri Dinleyici
    Eskisehir Osmangazi University, Department of Pediatric Infectious Disease and Intensive Care Unit, Eskisehir, Turkey
    Expert Opin Biol Ther 12:395-410. 2012
    Acute diarrhea continues to be a leading cause of morbidity, hospitalization and mortality worldwide and probiotics have been proposed as a complementary therapy in the treatment of acute diarrhea...
  87. pmc Probiotic prophylaxis of ventilator-associated pneumonia: a blinded, randomized, controlled trial
    Lee E Morrow
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Creighton University School of Medicine, Omaha, Nebraska, USA
    Am J Respir Crit Care Med 182:1058-64. 2010
    Enteral administration of probiotics may modify the gastrointestinal environment in a manner that preferentially favors the growth of minimally virulent species...
  88. pmc Exploring metabolic pathway reconstruction and genome-wide expression profiling in Lactobacillus reuteri to define functional probiotic features
    Delphine M Saulnier
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 6:e18783. 2011
    ..The production of bioactive metabolites by human-derived probiotics may be predicted using metabolic modeling and transcriptomics...
  89. ncbi Role of probiotics in pediatric patients with Helicobacter pylori infection: a comprehensive review of the literature
    Elena Lionetti
    Department of Paediatrics, University of Catania, Catania, Italy
    Helicobacter 15:79-87. 2010
    ..Current interest in probiotics as therapeutic agents against H...
  90. ncbi Mechanisms of action of probiotics: recent advances
    S C Ng
    Antigen Presentation Research Group, Imperial College London, London, UK
    Inflamm Bowel Dis 15:300-10. 2009
    ..Several new mechanisms by which probiotics exert their beneficial effects have been identified and it is now clear that significant differences exist ..
  91. ncbi Probiotics for prevention and treatment of diarrhea
    Stefano Guandalini
    Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Chicago, Chicago, IL60637, USA
    J Clin Gastroenterol 45:S149-53. 2011
    b>Probiotics have been extensively studied over the past several years in the prevention and, to a larger extent, in the treatment of diarrheal diseases, especially in pediatric populations. Diarrhea is a symptom, and not a disease...
  92. ncbi Impact of maternal supplementation with probiotics during pregnancy on atopic eczema in childhood--a meta-analysis
    Katja Doege
    Department of Gynecology, Universitatsklinikum Hamburg Eppendorf, Martinistrase 52, 20246 Hamburg, Germany
    Br J Nutr 107:1-6. 2012
    ..conduct a literature review of randomised, double-blind, placebo-controlled trials, which assessed the impact of probiotics intake during pregnancy on the development of eczema in children...
  93. ncbi Probiotics and immunity
    Andrea T Borchers
    Department of Nutrition, Allergy and Clinical Immunology, University of California at Davis, Davis, CA, USA
    J Gastroenterol 44:26-46. 2009
    b>Probiotics are defined as live microorganisms that, when administered in adequate amounts, confer a health benefit on the host, including the gastrointestinal tract...
  94. ncbi Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide
    Elise Macho Fernandez
    Bactéries Lactiques et Immunité des Muqueuses, Centre d Infection et d Immunité de Lille, Institut Pasteur de Lille, 1 rue du Pr Calmette, 59019 Lille Cedex, France
    Gut 60:1050-9. 2011
    ..Therapeutic use of probiotics is known to be strain specific, but precise mechanisms remain unclear...
  95. ncbi Benefits of a synbiotic formula (Synbiotic 2000Forte) in critically Ill trauma patients: early results of a randomized controlled trial
    Katerina Kotzampassi
    Department of Surgery, Faculty of Medicine, University of Thessaloniki, Thessaloniki, Greece
    World J Surg 30:1848-55. 2006
    Since probiotics are considered to exert beneficial health effects by enhancing the host's immune response, we investigated the benefits of a synbiotics treatment on the rate of infections, systemic inflammatory response syndrome (SIRS), ..
  96. pmc Probiotics-host communication: Modulation of signaling pathways in the intestine
    Carissa M Thomas
    Interdepartmental Program of Cell and Molecular Biology, Baylor College of Medicine, Houston, TX, USA
    Gut Microbes 1:148-63. 2010
    The intestinal microbiota includes a diverse group of functional microorganisms, including candidate probiotics or viable microorganisms that benefit the host...
  97. ncbi Lactobacilli as multifaceted probiotics with poorly disclosed molecular mechanisms
    Williams Turpin
    IRD, UMR 204 IRD Montpellier1 Montpellier2 SupAgro NUTRIPASS, F 34394 Montpellier, France
    Int J Food Microbiol 143:87-102. 2010
    ..Several lactobacilli have been recognized as probiotics due to their wide range of health-promoting effects in humans...
  98. pmc S layer protein A of Lactobacillus acidophilus NCFM regulates immature dendritic cell and T cell functions
    Sergey R Konstantinov
    Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB, Wageningen, The Netherlands
    Proc Natl Acad Sci U S A 105:19474-9. 2008
    ..In conclusion, the major S layer protein, SlpA, of L. acidophilus NCFM is the first probiotic bacterial DC-SIGN ligand identified that is functionally involved in the modulation of DCs and T cells functions...
  99. pmc Probiotics promote gut health through stimulation of epithelial innate immunity
    Cristiano Pagnini
    Digestive Health Research Center, University of Virginia Health System, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 107:454-9. 2010
    ..Our results support the hypothesis that probiotics promote gut health through stimulation, rather than suppression, of the innate immune system...
  100. ncbi Lactobacillus sepsis associated with probiotic therapy
    Michael H Land
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Pediatrics 115:178-81. 2005
    ..This report should not discourage the appropriate use of Lactobacillus or other probiotic agents but should serve as a reminder that these agents can cause invasive disease in certain populations...
  101. ncbi Review article: yeast as probiotics -- Saccharomyces boulardii
    D Czerucka
    INSERM U 526, Faculte de Medecine, université Nice Sophia Antipolis, Nice Cedex 2, France
    Aliment Pharmacol Ther 26:767-78. 2007
    b>Probiotics are defined as live micro-organisms which confer a health benefit on the host...

Research Grants82

  1. Developing Probiotics as Foods and Drugs - Scientific and Regulatory Challenges
    Patricia Hibberd; Fiscal Year: 2006
    ..unreadable] DESCRIPTION (provided by applicant): Fermented foods produced by "friendly" microbial organisms, or "probiotics," have been used historically to promote and sustain human and animal health...
  2. Effect of Lactobacillus GG on gut permeability and microbiome in VLBW neonates
    ROSE MARIE VISCARDI; Fiscal Year: 2013
    ..To mitigate the risk of NEC, the use of probiotics has been proposed to correct the intestinal barrier dysfunction and improve gut dysbiosis...
  3. Evaluation of a new class of antimicrobial agents against Clostridium difficile
    SAUL R contact TZIPORI; Fiscal Year: 2011
    ..While other interventions have been tried (probiotics, toxin-absorbing polymers, and toxoid vaccines), neither prevention nor treatment strategies have kept up with ..
  4. Novel Bacillus subtilis based spore vaccine to tuberculosis
    Subramanian Dhandayuthapani; Fiscal Year: 2013
    ..harmless to humans;in fact, they are sold in grocery stores and are being consumed in a number of novel foods as probiotics. Bacillus spores do not require special storage, and can be orally and nasally administered...
  5. Probiotic-Induced Elimination of Oxalate to treat Hyperoxaluria
    Marguerite Hatch; Fiscal Year: 2013
    ..we are proposing to examine the promotion of active intestinal elimination and luminal degradation of oxalate by probiotics as a way of managing two different clinical entities having in common an increased urinary excretion of oxalate ..
  6. Metagenomic profiling of oral polymicrobial flora in head and neck cancers
    Charis Eng; Fiscal Year: 2011
    ..bacterial indicators in order to provide early cancer or pre-cancer detection and perhaps prevention, based on probiotics or antibiotics...
  7. Role of Microbial Translocation in Cardiopulmonary Disease in Children with HIV
    Alison Morris; Fiscal Year: 2013
    ..MT is an attractive therapeutic target because it can be modulated directly with probiotics and/or antibiotics, and resultant inflammation can be targeted as well...
  8. Probiotics and HIF signaling in Alcoholic Liver Disease
    Wenke Feng; Fiscal Year: 2013
    ..Determine the effects of ethanol and probiotics on intestinal HIF signaling and mechanisms in ALD. Specific Aim 2...
  9. Gut microflora: Impact on neonatal immunity, viral gastroenteritis and vaccines
    ANASTASIA NICKOLAEVNA VLASOVA; Fiscal Year: 2013
    ..Studies of gnotobiotic (Gn) animals have revealed that probiotics or commensal microflora are crucial for gut immune maturation and homeostasis, but the mechanisms involved and ..
  10. The Intestinal Microbiome in Pediatric NAFLD
    Nita H Salzman; Fiscal Year: 2010
    ..of this disease through the manipulation and modulation of the intestinal microbiome or its functional metabolic capacity through the use of prebiotics, probiotics, antibiotics, or via other newly revealed mechanisms.
  11. Lactogenic immunity/probiotics: Effect on neonatal gut immunity
    Linda J Saif; Fiscal Year: 2010
    ..first assess the impact of colostrum (col)/milk and key maternal immunomediators (TGF2, IL4) on colonization by probiotics. We then determine the individual and combined effects of col/milk and LAB on immunologic maturation, moderation ..
  12. Probiotics-derived soluble proteins regulate intestinal inflammation
    Fang Yan; Fiscal Year: 2013
    ..However, the clinical application of LGG and other probiotics is limited by the paucity of information regarding their mechanisms of action...
  13. INTESTINAL MUCOSAL PROTECTION BY EPIDERMAL GROWTH FACTOR
    Radhakrishna Rao; Fiscal Year: 2013
    ..junctions involves of dephosphorylation of occludin on T403 and T404 by down regulation of PKC7, and c) EGF and probiotics prevent oxidative stress-induced tight junction disruption by a MAP kinase-dependent mechanism...
  14. Activation of Host-Probiotic Communication by Prebiotic Milk Oligosaccharides
    Helen E Raybould; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Probiotics and prebiotics are CAM interventions frequently employed by the American public to promote intestinal health and wellness...
  15. Enhancement of NAFLD risk by vinyl chloride: interaction of gut-liver-adipose axi
    JULIANE INGEBORG BEIER; Fiscal Year: 2013
    ..Supplementation with probiotics has been shown to decrease induced gut permeability and liver injury...
  16. Probiotics and Innate Intestinal Defense
    PATRICIA LANEE WEI DENNING; Fiscal Year: 2013
    ..Recent laboratory and clinical studies suggest that NEC may be prevented by probiotics, which may normalize bacterial populations within the gut of premature infants and also promote cytoprotective ..
  17. Milk oligosaccharides, bifidobacteria and intestinal epithelium.
    Maciej Chichlowski; Fiscal Year: 2011
    ..Beneficial bacteria (probiotics) have both direct and indirect effects on the host, including enhancement of epithelial barrier function, ..
  18. Mechanisms of Immune Modulation by Probiotics
    Lijuan Yuan; Fiscal Year: 2012
    ..The mechanism of immunostimulation will be identified by determining the effect of probiotics on dendritic cell (DC) maturation and function, toll-like receptor (TLR)9-expressing APC responses, Th1, Th2, ..
  19. Maturation of intestinal innate immunity and NEC
    W Allan Walker; Fiscal Year: 2013
    ..on the ontogeny of the control elements of TLR signaling pathways, and their modulation by steroids and probiotics. This mechanistic understanding of the effect of steroids and probiotics in preventing inflammation in premature ..
  20. Immature intestinal NF-kB regulation, probiotics, and necrotizing enterocolitis
    Erika C Claud; Fiscal Year: 2013
    ..b>Probiotics are bacteria which have beneficial health effects beyond their inherent nutritive value...
  21. Chicago Prevention and Intervention Epicenter (Chicago PIE)
    ROBERT ALAN WEINSTEIN; Fiscal Year: 2013
    ..CDIs result in part from the effect of antibiotics on intestinal microbes. Probiotics, mixtures of natural gut- stabilizing bacteria, given to patients receiving antibiotic therapy have the ..
  22. Innate Immune Protection by Clean Genome E. coli
    Frederick R Blattner; Fiscal Year: 2012
    ..The development of probiotics with the capacity to dampen or modulate this response would have enormous value and numerous medical ..
  23. INTESTINAL MUCOSAL PROTECTION BY EPIDERMAL GROWTH FACTOR
    Radhakrishna Rao; Fiscal Year: 2009
    ..junctions involves of dephosphorylation of occludin on T403 and T404 by down regulation of PKCh, and c) EGF and probiotics prevent oxidative stress-induced tight junction disruption by a MAP kinase-dependent mechanism...
  24. VSL for Asthma
    Alessio Fasano; Fiscal Year: 2010
    ..b>Probiotics (those microbes that produce only beneficial effects in the host gut), such as Lactobacillus and Bifidobacterium ..
  25. Bacterial fermentation in skin microbiome as probiotics (Bfismp) against S. aureu
    Chun Ming Huang; Fiscal Year: 2013
    ..human skin commensal bacteria, like yogurt made by fermentation with friendly gut bacteria, can function as skin probiotics for treatment of skin infections by pathogens...
  26. Novel therapies in alcoholic hepatitis University of Louisville
    Craig J McClain; Fiscal Year: 2013
    ..We will study the therapeutic efficacy of both live probiotics and probiotic supernatants...
  27. Mechanistic basis of probiotic prevention of osteoporosis
    Narayanan Parameswaran; Fiscal Year: 2013
    ..Our findings will also provide the foundation for future clinical studies to determine the effectiveness of probiotics to maximize bone health in post-menopausal women.
  28. Intestinal bacterial metagenome in pediatric NAFLD
    Nita H Salzman; Fiscal Year: 2013
    ..and treatment of this disease through the manipulation and modulation of the intestinal microbiome or its functional metabolic capacity through the use of prebiotics, probiotics, antibiotics, or via other newly revealed mechanisms.
  29. 3rd ASM Conference on Enterococci
    Don B Clewell; Fiscal Year: 2010
    ..the involvement of enterococci in food fermentations as well as exploration and use of certain strains as probiotics have been areas of significant interest...
  30. Symptom management for irritable bowel syndrome constipation (IBS-C)
    Joyce K Anastasi; Fiscal Year: 2013
    ..Current therapies include dietary modification, psychotherapy, probiotics, and pharmaceutical agents...
  31. 16th International Congress of Mucosal Immunology (ICMI 2013)
    Joanne L Viney; Fiscal Year: 2013
    ..homing, cytokines and chemokines, inflammation, mucosal antibodies, ocular and upper airway mucosal immunology, probiotics, innate immunity, antimicrobial defenses, among other topics...
  32. The Neonatal Microbiome and Necrotizing Enterocolitis
    Phillip I Tarr; Fiscal Year: 2012
    ..About 80% of cases occur within 35 days of birth among hospitalized newborns of low birth weight. Probiotics diminish the incidence and severity of NEC, and NEC does not occur antepartum...
  33. Effect of Lactobacillus on genital HIV-1 RNA and DNA shedding in women
    Jane E Hitti; Fiscal Year: 2010
    ..Lactobacillus modulates HIV-1 in the female genital tract, and may add rationale for further evaluation of probiotics as a potential secondary HIV-1 prevention strategy...
  34. BARRIER FUNCTION OF THE GI TRACT IN HEALTH AND DISEASE
    W Allan Walker; Fiscal Year: 2013
    ..explain excessive intestinal inflammation in prematures and test maturational prevention with hydrocortisone and probiotics. Project 2 will examine the mechanisms involved in the participation of corticotropin-releasing hormone family ..
  35. Microbiomes and Inflammation in Chronic Fatigue Syndrome
    RUTH EMILY LEY; Fiscal Year: 2013
    ..toward that of healthier individuals in the hopes of ameliorating symptoms and could reveal whether trials of probiotics and antimicrobial or particular inflammation-modulating drugs may be warranted...
  36. IMpact of PRObiotics for reducing infections in VEterans: The IMPROVE Study
    Nasia Safdar; Fiscal Year: 2013
    ..Adherence will be encouraged by weekly phone calls. If found to be efficacious, probiotics represent an easily implementable, safe, and well-tolerated intervention that is suitable for use in a field ..
  37. Safety and Effect of L. reuteri on Biomarkers of Inflammation in Healthy Infants
    Jon Marc Rhoads; Fiscal Year: 2013
    ..measurement of regulatory T-cells (Tregs), the cells proposed to mediate the immunomodulatory effects of probiotics. Thus, our Primary Aim is to demonstrate (in a two-year trial) if Lactobacillus reuteri is safe in healthy ..
  38. Probiotic Yogurt for the Treatment of Minimal Hepatic Encephalopathy
    Jasmohan S Bajaj; Fiscal Year: 2011
    ..Results generated from this study will form the basis for a RO1 proposal to develop the use of probiotics as a biologically-based alternative treatment with long-term outcomes of prognosis, development of overt ..
  39. Microbiome as Therapeutic Target in Alcoholic Hepatitis
    BERND G SCHNABL; Fiscal Year: 2013
    ..dysbiosis by reducing bacterial overgrowth using non-absorbable antibiotics, by restoring eubiosis using probiotics, or by altering the enteric metabolome using fatty acid supplementation...
  40. Estrogenic Modulation of Genitourinary Epithelial-Probiotic Cross-Talk
    MICHAEL HARRISON HSIEH; Fiscal Year: 2013
    ..biofilms may depend on estrogen-induced, epithelial production of glycogen, a food source for commensal-derived probiotics, "live microorganisms which when administered in adequate amounts confer a health benefit on the host"...
  41. Gastro-intestinal microbes degrading dietary gluten
    EVA JOSEPHINE HELMERHORST; Fiscal Year: 2013
    ..Reduction of gluten toxicity by natural colonizers of the gastrointestinal tract would offer novel treatment perspectives in the form of probiotics or applications of pure gluten-degrading enzymes.
  42. Salmonella polymicrobial interactions
    BRIAN M AHMER; Fiscal Year: 2012
    ..This will facilitate the rational design and use of antibiotics and probiotics.
  43. Role of Dendritic Cells in H pylori-induced Treg-mediated Host Immune Tolerance
    John Y Kao; Fiscal Year: 2013
    ..g., prebiotics, probiotics)...
  44. GI Barrier and Microbiome Response to VSL3 in Irritable Bowel Syndrome
    Robert Shulman; Fiscal Year: 2012
    ..Certain probiotics such as VSL#3 may act to improve these factors and thus, reduce the pain and stooling symptoms of IBS...
  45. Probiotics to Improve Outcomes of Clostridium difficile
    Nasia Safdar; Fiscal Year: 2013
    ..The study will provide important preliminary pilot data for a subsequent larger study to examine the efficacy of probiotics for CDI...
  46. Necrotizing Enterocolitis: Prevention and Prediction
    MARK ALAN UNDERWOOD; Fiscal Year: 2012
    ..By giving different doses and combinations of live healthy bacteria (probiotics) and fiber (prebiotics) to premature infants, we aim to find the best way to change the bacteria in the ..
  47. Nature inspired treatments for persistent C. difficile infections
    Julian G Hurdle; Fiscal Year: 2013
    ..e. probiotics), including Lactobacillus spp., to suppress gut pathogens such as C...
  48. Phase I: Safety and Tolerance of Lactobactocillus reuteri in Adults
    Jon Marc Rhoads; Fiscal Year: 2011
    ..Public Health Relevance: Our studies would provide evidence for safety of probiotics, more specifically l. reuteri...
  49. Yogurt beverages as a vehicle to deliver high dose probiotics
    Daniel J Merenstein; Fiscal Year: 2013
    Abstract: Probiotics are live microorganisms that, when administered in sufficient amounts, may improve health. Often, probiotics are ingested as supplements in powder, pill or liquid forms, designed specifically for medicinal benefit...
  50. Mechanism of Activation of Probiotic Bifidobacteria by Prebiotic Milk Glycans
    Carolyn Slupsky; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Probiotics and prebiotics are CAM interventions frequently employed by the American public to promote intestinal health and wellness...
  51. Foregut microbiome in development of esophageal adenocarcinoma
    Zhiheng Pei; Fiscal Year: 2012
    ..the cause of GERD might become possible, for example, by normalizing the microbiota through use of antibiotics, probiotics, or prebiotics...
  52. Pathways to New Biomarkers in Recurrent Abdominal Pain in Children
    Robert Shulman; Fiscal Year: 2013
    ..Our results could shift the paradigm of treatment from one-size-fits-all to targeted management (e.g., probiotics for those with abnormal GI markers and low psychosocial distress)...
  53. Probiotics: Potential Therapeutic Roles in Diarrhea
    Pradeep K Dudeja; Fiscal Year: 2013
    ....
  54. Modulation of NF-kB Signaling by Immunoprobiotics
    James Versalovic; Fiscal Year: 2011
    ..is that glycerol/glycerophospholipid metabolism is a focal point for determining the relative capacities of probiotics to suppress NF-?B and MAP kinase signaling in mammalian cells...
  55. Novel Therapies for Alcoholic Hepatitis
    Gyongyi Szabo; Fiscal Year: 2013
    ..The second trial will compare probiotics (to improve gut-barrier function) to placebo in patients with moderate AH...
  56. METAGENOMIC ENGINEERING OF PROBIOTIC BACTERIA TO IMPROVE INTESTINAL COLONIZATION
    Gautam Dantas; Fiscal Year: 2012
    ..Disruption of the microbiota can lead to a number of pathologies in the host, and probiotics have emerged as a potential solution for treating or preventing such dysbioses...
  57. Midcareer Investigator Award in Patient-Oriented Research (k24)
    Patricia L Hibberd; Fiscal Year: 2013
    ..through high quality translational clinical research, novel collaborations to optimize the potential impact of probiotics on the prevention and treatment of infectious diseases, and innovative scientific solutions to the challenges of ..
  58. Microbial Ecology of the Zebrafish Intestine
    John F Rawls; Fiscal Year: 2013
    ..Such knowledge is essential for the rational design of prebiotics, probiotics, and antibiotics to treat human pathologies associated with imbalances of the microbiota such as inflammatory ..
  59. Probiotics in Pediatric Diarrhea in Peru_Supplement
    Richard A Oberhelman; Fiscal Year: 2012
    ....
  60. The Role of the Microbiome in the Development/Prevention of Food Allergies
    Gary B Huffnagle; Fiscal Year: 2011
    ..Therefore, strategies aimed at the microbiota (probiotics &prebiotcs) have the potential to restore defective regulatory responses and/or prevent allergen priming...
  61. Probiotics to Enhance Influenza Vaccine Immunogenicity
    Patricia L Hibberd; Fiscal Year: 2013
    ..In vitro studies and animal data show that probiotics, particularly Lactobacillus GG (LGG), have immunomodulatory properties...
  62. Effects of Probiotics in Patients with Cystic Fibrosis
    Patricia L Hibberd; Fiscal Year: 2013
    ..b>Probiotics, particularly Lactobacillus GG (LGG) are capable of killing various bacteria, including S aureus and P ..
  63. Thermostable vaginal probiotic microbicide
    VICTOR BRONSHTEIN; Fiscal Year: 2012
    ..To achieve this goal we will stabilize vaginal probiotics for long-term storage at high ambient temperatures and short term survival at temperatures required for quick ..
  64. The impact of Helicobacter pylori infection on inflammatory bowel disease suscept
    John Kao; Fiscal Year: 2009
    ..The completion of this project will also offer a potential mechanism through which beneficial bacteria (e.g., probiotics) may help to prevent IBD flares...
  65. Use of Probiotic Conditioned Media to Protect Against Necrotizing Enterocolitis
    ERIKA CLAUD; Fiscal Year: 2009
    ..proposal is to utilize a complex formulation of natural bioactive components synthesized and secreted by the probiotics in a solution that is bacteria-free...
  66. Foregut microbiome in development of esophageal adenocarcinoma
    Zhiheng Pei; Fiscal Year: 2009
    ..the cause of GERD might become possible, for example, by normalizing the microbiota through use of antibiotics, probiotics, or prebiotics...
  67. Probiotics for Infectious Diarrhea in Children in South India
    Honorine Ward; Fiscal Year: 2009
    ..PAR-07-216 (Indo- US Program for Maternal and Child Health) is to investigate whether the modulatory effects of probiotics in the gastrointestinal tract promote restoration of intestinal function and enhance the immune response in ..
  68. VSL for Asthma
    Alessio Fasano; Fiscal Year: 2009
    ..b>Probiotics (those microbes that produce only beneficial effects in the host gut), such as Lactobacillus and Bifidobacterium ..
  69. Effects of Probiotic Lactobacilli on Rotavirus Immunity
    Lijuan Yuan; Fiscal Year: 2006
    Rotaviruses are the leading cause of severe gastroenteritis in infants and children worldwide. Probiotics, such as Lactobacilli have been shown to reduce the severity of rotavirus diarrhea; however the immunologic mechanisms have not been ..
  70. Feasibility Study of Probiotics for Growth Faltering
    Christine Wanke; Fiscal Year: 2006
    ..These data will be used, with the feasibility data obtained, to prepare a proposal for a full clinical trial of LGG as an intervention for growth faltering and diarrheal disease at the time of weaning in these children. ..
  71. The Neonatal Microbiome and Necrotizing Enterocolitis
    Phillip Tarr; Fiscal Year: 2009
    ..About 80% of cases occur within 35 days of birth among hospitalized newborns of low birth weight. Probiotics diminish the incidence and severity of NEC, and NEC does not occur antepartum...
  72. Structural, genetic, and functional analyses of the glycoproteins of Bacteroides
    LAURIE COMSTOCK; Fiscal Year: 2009
    ..will allow us to better understand how these microorganisms are affecting the host with either beneficial (probiotics, immune regulation and tolerance, maturation of the epithelial surface) or deleterious (transfer of antibiotic ..
  73. Regulation of the multiple polysaccharides of Bacteroides fragilis
    Laurie E Comstock; Fiscal Year: 2010
    ..will ultimately allow us to better understand how these microorganisms affect the host with either beneficial (probiotics, immune regulation and tolerance, and maturation of the epithelial surface) or deleterious (induction of abscess ..
  74. IN VITRO MODEL OF HUMAN VAGINAL EPITHELIUM
    Ann Stapleton; Fiscal Year: 2000
    ..opportunities for studying numerous aspects of women's urogenital health, including testing vaginal products, probiotics, and contraceptives; understanding protective roles of organisms in the normal flora; and studying the cellular ..
  75. PROBIOTICS IN PEDIATRIC DIARRHEA IN PERU: PLANNING GRANT
    Richard Oberhelman; Fiscal Year: 2006
    ..probiotic agents used, and causes of diarrhea make it difficult to determine the most appropriate role for probiotics in childhood diarrhea in malnourished populations from developing countries...
  76. Synbiotics as Adjuvant to Influenza Vaccine in Elderly
    Abinash Virk; Fiscal Year: 2006
    ..Antibody response against hemagglutinins of influenza A and B strains used in the 2006 vaccine will be studied. Probiotics are viable commensal microorganisms promote the establishment of beneficial microflora...
  77. Using Affymetrix Microflora array to study microflora composition in children wit
    Oleg Paliy; Fiscal Year: 2009
    ..during intestinal diseases retards the development and evaluation of new and exciting medicines, such as probiotics. Our long-term goal is to study microflora dynamics during intestinal disorders and to assess the use of ..
  78. Advances in Allergy, Asthma and Immunology
    Leonard Bielory; Fiscal Year: 2002
    ..for the Overview of CAM; Overview of Herbal Medicine in Asthma; Overview of Homeopathy in Allergies; Overview of Probiotics in Atopic Dermatitis; Medico-Legal Aspects and Adverse Reactions...
  79. The role of iron/heme acquisition mechanisms in Bacteroides fragilis.
    EDSON ROCHA; Fiscal Year: 2009
    ..This study is aimed to provide new information that may lead to new prebiotics and probiotics therapeutic strategies to control and manipulate the intestinal microflora population.
  80. 14th International Congress of Mucosal Immunology
    Richard Blumberg; Fiscal Year: 2009
    ..homing, cytokines and chemokines, inflammation, mucosal antibodies, ocular and upper airway mucosal immunology, probiotics, innate immunity, antimicrobial defenses, among other topics...
  81. Probiotics to Eradicate Nasal S Aureus in ESRD Patients
    Patricia Hibberd; Fiscal Year: 2004
    ..b>Probiotics, particularly Lactobacillus GG (LGG) are capable of killing various bacteria, including Staphylococcus aureus, ..
  82. Probiotic Modulation/Dendritic Cells in Experimental IBD
    Maureen Drakes; Fiscal Year: 2006
    ..Even though recent reports support a role for bacterial probiotics in restoring the immune balance and demonstrate some efficacy of these organisms as a means of treating the ..