dietary supplements

Summary

Summary: Products in capsule, tablet or liquid form that provide essential nutrients, such as a vitamin, an essential mineral, a protein, an herb, or similar nutritional substance. (FDA Backgrounder, June 15, 1993, p2)

Top Publications

  1. ncbi Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance
    Mari Carmen Gomez-Cabrera
    Department of Physiology, Faculty of Medicine, University of Valencia, Valencia, Spain
    Am J Clin Nutr 87:142-9. 2008
  2. pmc Human pharmacology of a performance-enhancing dietary supplement under resting and exercise conditions
    Christine A Haller
    Department of Medicine, Division of Clinical Pharmacology, University of California, San Francisco, San Francisco General Hospital, San Francisco, CA, USA
    Br J Clin Pharmacol 65:833-40. 2008
  3. pmc Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials
    H A Bischoff-Ferrari
    Centre on Aging and Mobility, University of Zurich, Switzerland
    BMJ 339:b3692. 2009
  4. ncbi EPA but not DHA appears to be responsible for the efficacy of omega-3 long chain polyunsaturated fatty acid supplementation in depression: evidence from a meta-analysis of randomized controlled trials
    Julian G Martins
    Academy of Nutritional Medicine, 80 Commercial End, Swaffham Bulbeck, Cambridge CB25 0NE, UK
    J Am Coll Nutr 28:525-42. 2009
  5. ncbi n-3 fatty acids and cardiovascular events after myocardial infarction
    Daan Kromhout
    Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    N Engl J Med 363:2015-26. 2010
  6. ncbi n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases
    Philip C Calder
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, United Kingdom
    Am J Clin Nutr 83:1505S-1519S. 2006
  7. ncbi Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study
    E Hypponen
    Department of Paediatric Epidemiology and Biostatistics, Institute of Child Health, WC1N 1EH, London, UK
    Lancet 358:1500-3. 2001
  8. pmc Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
    Scott M Lippman
    Division of Cancer Medicine, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    JAMA 301:39-51. 2009
  9. pmc Vitamin D and type 2 diabetes: a systematic review
    J Mitri
    Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Boston, MA 02111, USA
    Eur J Clin Nutr 65:1005-15. 2011
  10. ncbi Standardized methods for the determination of antioxidant capacity and phenolics in foods and dietary supplements
    Ronald L Prior
    U S Department of Agriculture, Arkansas Children s Nutrition Center, 1120 Marshall Street, Little Rock, Arkansas 72202, USA
    J Agric Food Chem 53:4290-302. 2005

Detail Information

Publications293 found, 100 shown here

  1. ncbi Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance
    Mari Carmen Gomez-Cabrera
    Department of Physiology, Faculty of Medicine, University of Valencia, Valencia, Spain
    Am J Clin Nutr 87:142-9. 2008
    ..There is, however, considerable debate regarding the beneficial health effects of vitamin C supplementation...
  2. pmc Human pharmacology of a performance-enhancing dietary supplement under resting and exercise conditions
    Christine A Haller
    Department of Medicine, Division of Clinical Pharmacology, University of California, San Francisco, San Francisco General Hospital, San Francisco, CA, USA
    Br J Clin Pharmacol 65:833-40. 2008
    Performance-enhancing dietary supplements have not been clinically tested for safety or efficacy...
  3. pmc Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials
    H A Bischoff-Ferrari
    Centre on Aging and Mobility, University of Zurich, Switzerland
    BMJ 339:b3692. 2009
    ..To test the efficacy of supplemental vitamin D and active forms of vitamin D with or without calcium in preventing falls among older individuals...
  4. ncbi EPA but not DHA appears to be responsible for the efficacy of omega-3 long chain polyunsaturated fatty acid supplementation in depression: evidence from a meta-analysis of randomized controlled trials
    Julian G Martins
    Academy of Nutritional Medicine, 80 Commercial End, Swaffham Bulbeck, Cambridge CB25 0NE, UK
    J Am Coll Nutr 28:525-42. 2009
    ..However, the results of randomized controlled trials are mixed and controversy exists as to whether either eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) or both are responsible for the reported benefits...
  5. ncbi n-3 fatty acids and cardiovascular events after myocardial infarction
    Daan Kromhout
    Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    N Engl J Med 363:2015-26. 2010
    ....
  6. ncbi n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases
    Philip C Calder
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, United Kingdom
    Am J Clin Nutr 83:1505S-1519S. 2006
    ..The precursor n-3 PUFA alpha-linolenic acid does not appear to exert antiinflammatory effects at achievable intakes...
  7. ncbi Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study
    E Hypponen
    Department of Paediatric Epidemiology and Biostatistics, Institute of Child Health, WC1N 1EH, London, UK
    Lancet 358:1500-3. 2001
    ..Dietary vitamin D supplementation is associated with reduced risk of type 1 diabetes in animals. Our aim was to ascertain whether or not vitamin D supplementation or deficiency in infancy could affect development of type 1 diabetes...
  8. pmc Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
    Scott M Lippman
    Division of Cancer Medicine, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    JAMA 301:39-51. 2009
    ..Secondary analyses of 2 randomized controlled trials and supportive epidemiologic and preclinical data indicated the potential of selenium and vitamin E for preventing prostate cancer...
  9. pmc Vitamin D and type 2 diabetes: a systematic review
    J Mitri
    Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Boston, MA 02111, USA
    Eur J Clin Nutr 65:1005-15. 2011
    ..Vitamin D may modify the risk of type 2 diabetes mellitus. The aim of this review was to examine the association between vitamin D status and incident type 2 diabetes, and the effect of vitamin D supplementation on glycemic outcomes...
  10. ncbi Standardized methods for the determination of antioxidant capacity and phenolics in foods and dietary supplements
    Ronald L Prior
    U S Department of Agriculture, Arkansas Children s Nutrition Center, 1120 Marshall Street, Little Rock, Arkansas 72202, USA
    J Agric Food Chem 53:4290-302. 2005
    ..The TEAC assay represents a second ET-based method. Other assays may need to be considered in the future as more is learned about some of the other radical sources and their importance to human biology...
  11. pmc Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
    Eric A Klein
    Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    JAMA 306:1549-56. 2011
    ..Longer follow-up and more prostate cancer events provide further insight into the relationship of vitamin E and prostate cancer...
  12. pmc Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis
    Mark J Bolland
    Department of Medicine, University of Auckland, Private Bag 92 019, Auckland 1142, New Zealand
    BMJ 342:d2040. 2011
    ....
  13. ncbi Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial
    Joan M Lappe
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    Am J Clin Nutr 85:1586-91. 2007
    ..Numerous observational studies have found supplemental calcium and vitamin D to be associated with reduced risk of common cancers. However, interventional studies to test this effect are lacking...
  14. ncbi Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials
    Philippe Autier
    International Agency for Research on Cancer, 150 cours Albert Thomas, F 69372 Lyon, France
    Arch Intern Med 167:1730-7. 2007
    ..We examined the risk of dying from any cause in subjects who participated in randomized trials testing the impact of vitamin D supplementation (ergocalciferol [vitamin D(2)] or cholecalciferol [vitamin D(3)]) on any health condition...
  15. ncbi Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis
    Goran Bjelakovic
    The Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Center for Clinical Intervention Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    JAMA 297:842-57. 2007
    ..Antioxidant supplements are used for prevention of several diseases...
  16. pmc Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a randomised placebo controlled trial
    Pilar Galan
    UMR U557 INSERM, U1125 Inra, CNAM, Universite Paris 13, CRNH IdF, F 93017 Bobigny, France
    BMJ 341:c6273. 2010
    ..To investigate whether dietary supplementation with B vitamins or omega 3 fatty acids, or both, could prevent major cardiovascular events in patients with a history of ischaemic heart disease or stroke...
  17. pmc Vitamin D - effects on skeletal and extraskeletal health and the need for supplementation
    Matthias Wacker
    Vitamin D, Skin and Bone Research Laboratory, Section of Endocrinology, Nutrition, and Diabetes, Department of Medicine, Boston University Medical Center, 85 East Newton Street, M 1013, Boston, MA 02118, USA
    Nutrients 5:111-48. 2013
    ....
  18. ncbi Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality
    Edgar R Miller
    The Johns Hopkins School of Medicine, and The Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2223, USA
    Ann Intern Med 142:37-46. 2005
    ..However, several trials of high-dosage vitamin E supplementation showed non-statistically significant increases in total mortality...
  19. pmc Systematic review: Vitamin D and cardiometabolic outcomes
    Anastassios G Pittas
    Tufts Medical Center and Friedman School of Nutrition Science and Policy, and Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Ann Intern Med 152:307-14. 2010
    ..Vitamin D may modify risk for cardiometabolic outcomes (type 2 diabetes, hypertension, or cardiovascular disease)...
  20. ncbi A single dose of vitamin D enhances immunity to mycobacteria
    Adrian R Martineau
    Centre for Health Sciences, Queen Mary s School of Medicine and Dentistry, Barts and The London, and Department of Clinical Biochemistry, North West London Hospitals NHS Trust, Northwick Park Hospital, Harrow, E1 2AT, UK
    Am J Respir Crit Care Med 176:208-13. 2007
    ..Vitamin D was used to treat tuberculosis (TB) in the preantibiotic era. Prospective studies to evaluate the effect of vitamin D supplementation on antimycobacterial immunity have not previously been performed...
  21. pmc Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis
    Laura Tripkovic
    Department of Nutrition and Metabolism, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK
    Am J Clin Nutr 95:1357-64. 2012
    ..Currently, there is a lack of clarity in the literature as to whether there is a definitive difference between the effects of vitamins D2 and D3 in the raising of serum 25-hydroxyvitamin D [25(OH)D]...
  22. pmc Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectiveness
    Bruce W Hollis
    Division of Neonatology and Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Bone Miner Res 26:2341-57. 2011
    ....
  23. pmc Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial
    Howard D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    JAMA 300:2123-33. 2008
    ..However, few long-term trials have evaluated men at initially low risk of cardiovascular disease, and no previous trial in men has examined vitamin C alone in the prevention of cardiovascular disease...
  24. ncbi Effect of beta-alanine supplementation on muscle carnosine concentrations and exercise performance
    Craig Sale
    School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham, NG11 8NS, UK
    Amino Acids 39:321-33. 2010
    ..In addition, the effects of training, with or without beta-alanine supplementation, on muscle carnosine concentrations are also reviewed...
  25. ncbi Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37 485 individuals
    Robert Clarke
    University of Oxford, England
    Arch Intern Med 170:1622-31. 2010
    ..Dietary supplementation with folic acid to lower homocysteine levels had no significant effects within 5 years on cardiovascular events or on overall cancer or mortality in the populations studied...
  26. ncbi High doses of vitamin D to reduce exacerbations in chronic obstructive pulmonary disease: a randomized trial
    An Lehouck
    University Hospitals Leuven, Belgium
    Ann Intern Med 156:105-14. 2012
    ..Because many patients with chronic obstructive pulmonary disease (COPD) have vitamin D deficiency, effects of vitamin D supplementation may extend beyond preventing osteoporosis...
  27. ncbi Cardiovascular effects of marine omega-3 fatty acids
    Palaniappan Saravanan
    Cardiovascular Research Group, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK
    Lancet 376:540-50. 2010
    ..We review evidence for the effects of omega-3 polyunsaturated fatty acids on various cardiac disorders and the risk factors for cardiac disease. We also assess areas of uncertainty needing further research...
  28. ncbi The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals
    Serge Hercberg
    Institut National de la Sante et de la Recherche Medicale, Unité de Recherche Médicale INSERM Institut National de la Recherche Agronomique Conservatoire National des Ants et Métiers CNAM, Paris, France
    Arch Intern Med 164:2335-42. 2004
    ..We tested the efficacy of nutritional doses of supplementation with a combination of antioxidant vitamins and minerals in reducing the incidence of cancer and ischemic cardiovascular disease in the general population...
  29. ncbi Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: a randomized controlled trial
    Maria Makrides
    Child Nutrition Research Centre, Women s and Children s Health Research Institute, Women s and Children s Hospital, 72 King William Rd, North Adelaide SA 5006, Australia
    JAMA 304:1675-83. 2010
    ..Uncertainty about the benefits of dietary docosahexaenoic acid (DHA) for pregnant women and their children exists, despite international recommendations that pregnant women increase their DHA intakes...
  30. ncbi Omega-3 fatty acids reverse age-related decreases in nuclear receptors and increase neurogenesis in old rats
    Simon C Dyall
    Neuroscience Centre, ICMS, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary University of London, Whitechapel, London, United Kingdom
    J Neurosci Res 88:2091-102. 2010
    ..These observations illustrate additional mechanisms that might underlie the neuroprotective effects of omega-3 fatty acids in ageing...
  31. ncbi Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial)
    Stuart Richer
    Department of Veterans Affairs, Medical Center Eye Clinic, North Chicago, Illinois 60064 3095, USA
    Optometry 75:216-30. 2004
    ....
  32. pmc Maternal methyl-donor supplementation induces prolonged murine offspring colitis susceptibility in association with mucosal epigenetic and microbiomic changes
    Tiffany D Schaible
    Department of Pediatrics, Baylor College of Medicine, Texas Children s Hospital, USDA ARS Children s Nutrition Research Center, Houston, TX, USA
    Hum Mol Genet 20:1687-96. 2011
    ..These findings underscore that epigenomic reprogramming relevant to mammalian colitis can occur during early development in response to maternal dietary modifications...
  33. ncbi Long-term follow-up for mortality and cancer in a randomized placebo-controlled trial of vitamin D(3) and/or calcium (RECORD trial)
    Alison Avenell
    Health Services Research Unit, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    J Clin Endocrinol Metab 97:614-22. 2012
    ..Vitamin D or calcium supplementation may have effects on vascular disease and cancer...
  34. ncbi Meta-analysis of vitamin D, calcium and the prevention of breast cancer
    Peizhan Chen
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Rm 427, 41 Building, 320 Yueyang Road, 200031 Shanghai, People s Republic of China
    Breast Cancer Res Treat 121:469-77. 2010
    ..These results provide strong evidence that vitamin D and calcium have a chemopreventive effect against breast cancer...
  35. ncbi Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial
    I Min Lee
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    JAMA 294:56-65. 2005
    ..Randomized trials do not generally support benefits of vitamin E, but there are few trials of long duration among initially healthy persons...
  36. ncbi Use of dietary supplements in the European Prospective Investigation into Cancer and Nutrition calibration study
    G Skeie
    Institute of Community Medicine, University of Tromsø, Tromsø, Norway
    Eur J Clin Nutr 63:S226-38. 2009
    ..The aim of this study was to describe the use of dietary supplements in subsamples of the 10 countries participating in the European Prospective Investigation into Cancer and ..
  37. ncbi Dietary supplement use by US adults: data from the National Health and Nutrition Examination Survey, 1999-2000
    Kathy Radimer
    Division of Health and Nutrition Examination Surveys, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD 20782, USA
    Am J Epidemiol 160:339-49. 2004
    ....
  38. ncbi Can supplementation with vitamin D reduce the risk or modify the course of autoimmune diseases? A systematic review of the literature
    Antonio Antico
    Laboratorio di Patologia Clinica, Ospedale Civile, Cittadella, Italy
    Autoimmun Rev 12:127-36. 2012
    ..To evaluate whether vitamin D levels are related to the risk of developing autoimmune diseases and whether supplementation with vitamin D can modify the course of the diseases...
  39. ncbi The impact of macular pigment augmentation on visual performance using different carotenoid formulations
    James Loughman
    Optometry Department, Dublin Institute of Technology, Dublin, Ireland
    Invest Ophthalmol Vis Sci 53:7871-80. 2012
    ..To investigate changes in macular pigment optical density (MPOD) and visual performance following supplementation with different macular carotenoid formulations...
  40. ncbi Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial
    Stefanie S Schleithoff
    Institute of Nutrition and Food Science, University of Bonn, Bonn, Germany
    Am J Clin Nutr 83:754-9. 2006
    ..In vitro studies suggest that vitamin D suppresses proinflammatory cytokines and increases antiinflammatory cytokines...
  41. pmc Calcium and vitamin D supplementation is associated with decreased abdominal visceral adipose tissue in overweight and obese adults
    Jennifer L Rosenblum
    Massachusetts General Hospital Weight Center and Gastrointestinal Unit, Massachusetts General Hospital, Boston, USA
    Am J Clin Nutr 95:101-8. 2012
    ..Several studies suggest that calcium and vitamin D (CaD) may play a role in the regulation of abdominal fat mass...
  42. pmc Effect of calcium supplementation in pregnancy on maternal bone outcomes in women with a low calcium intake
    Landing M A Jarjou
    Medical Research Council Keneba, Keneba, The Gambia
    Am J Clin Nutr 92:450-7. 2010
    ..Mobilization of maternal bone mineral partly supplies calcium for fetal and neonatal bone growth and development...
  43. doi Systematic review of the efficacy and effectiveness of complementary feeding interventions in developing countries
    Kathryn G Dewey
    Program in International and Community Nutrition, University of California, Davis, California 95616 8669, USA
    Matern Child Nutr 4:24-85. 2008
  44. ncbi Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial
    Heike A Bischoff
    Department of Orthopaedics, University of Basel, Basel, Switzerland
    J Bone Miner Res 18:343-51. 2003
    ..Over this short-term intervention, recurrent fallers seem to benefit most by the treatment. The impact of vitamin D on falls might be explained by the observed improvement in musculoskeletal function...
  45. ncbi Supplementation with all three macular carotenoids: response, stability, and safety
    Eithne E Connolly
    Macular Pigment Research Group, Department of Chemical and Life Sciences, Waterford Institute of Technology, Waterford, Ireland
    Invest Ophthalmol Vis Sci 52:9207-17. 2011
    ..This study was designed to investigate serum and macular response to, and safety of supplementation with, meso-zeaxanthin (MZ), lutein (L), and zeaxanthin (Z), the carotenoids that constitute macular pigment (MP)...
  46. ncbi Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels
    J A Sugden
    Department of Clinical Pharmacology, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
    Diabet Med 25:320-5. 2008
    ..To test whether a single large dose of vitamin D2 can improve endothelial function in patients with Type 2 diabetes mellitus and low serum 25-hydroxyvitamin D levels...
  47. ncbi Calcium/vitamin D supplementation and cardiovascular events
    Judith Hsia
    Department of Medicine, George Washington University, Washington, DC, USA
    Circulation 115:846-54. 2007
    ..We evaluated the risk of coronary and cerebrovascular events in the Women's Health Initiative randomized trial of calcium plus vitamin D supplementation...
  48. ncbi Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren
    Mitsuyoshi Urashima
    Division of Molecular Epidemiology, Jikei University School of Medicine, Nishi Shimbashi 3 25 8, Minato ku, Tokyo 105 8461, Japan
    Am J Clin Nutr 91:1255-60. 2010
    ..To our knowledge, no rigorously designed clinical trials have evaluated the relation between vitamin D and physician-diagnosed seasonal influenza...
  49. ncbi Amino acids: metabolism, functions, and nutrition
    Guoyao Wu
    Department of Animal Science, Faculty of Nutrition, Texas A and M University, College Station, TX, 77843, USA
    Amino Acids 37:1-17. 2009
    ..Thus, AA have important functions in both nutrition and health...
  50. pmc Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis
    Mark J Bolland
    Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92 019, Auckland 1142, New Zealand
    BMJ 341:c3691. 2010
    ..To investigate whether calcium supplements increase the risk of cardiovascular events...
  51. ncbi The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults
    Anastassios G Pittas
    Department of Endocrinology, Diabetes, and Metabolism, Tufts New England Medical Center, Boston, MA 02111, USA
    Diabetes Care 30:980-6. 2007
    ..We sought to compare the effects of combined calcium and vitamin D supplementation versus placebo on blood glucose and markers of inflammation in nondiabetic adults aged > or =65 years...
  52. ncbi Risk assessment for vitamin D
    John N Hathcock
    Council for Responsible Nutrition, Washington, DC 20036 5114, USA
    Am J Clin Nutr 85:6-18. 2007
    ..Collectively, the absence of toxicity in trials conducted in healthy adults that used vitamin D dose > or = 250 microg/d (10,000 IU vitamin D3) supports the confident selection of this value as the UL...
  53. ncbi The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of current knowledge and consensus recommendations
    Berthold Koletzko
    Department of Pediatrics, University of Munich, Munchen, Germany
    J Perinat Med 36:5-14. 2008
    ..Dietary LC-PUFA supply should continue after the first six months of life, but currently there is not sufficient information for quantitative recommendations...
  54. pmc Risks and benefits of omega 3 fats for mortality, cardiovascular disease, and cancer: systematic review
    Lee Hooper
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ
    BMJ 332:752-60. 2006
    ..To review systematically the evidence for an effect of long chain and shorter chain omega 3 fatty acids on total mortality, cardiovascular events, and cancer...
  55. pmc Examination of vitamin intakes among US adults by dietary supplement use
    Regan Lucas Bailey
    Office of Dietary Supplements, National Institutes of Health, 6100 Executive Blvd, Bethesda, MD 20892 7517, USA
    J Acad Nutr Diet 112:657-663.e4. 2012
    More than half of US adults use dietary supplements. Some reports suggest that supplement users have higher vitamin intakes from foods than nonusers, but this observation has not been examined using nationally representative survey data.
  56. ncbi Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: a meta-analysis of randomized controlled trials
    Kenneth H Brown
    Program in International Nutrition and the Department of Nutrition, University of California, Davis 95616, USA
    Am J Clin Nutr 75:1062-71. 2002
    ..Multiple studies have been carried out to assess the effect of zinc supplementation on children's growth. The results of these studies are inconsistent, and the factors responsible for these varied outcomes are unknown...
  57. ncbi n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review
    Chenchen Wang
    Tufts New England Medical Center Evidence based Practice Center, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, MA, USA
    Am J Clin Nutr 84:5-17. 2006
    ..The evidence for the benefits of fish oil is stronger in secondary- than in primary-prevention settings. Adverse effects appear to be minor...
  58. ncbi The effect of high doses of folic acid and iron supplementation in early-to-mid pregnancy on prematurity and fetal growth retardation: the mother-child cohort study in Crete, Greece (Rhea study)
    Eleni Papadopoulou
    Centre for Research in Environmental Epidemiology, Barcelona, Spain
    Eur J Nutr 52:327-36. 2013
    ....
  59. ncbi Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers
    Armin Zittermann
    Klinik für Thorax und Kardiovaskularchirurgie and Institut für Laboratoriums und Transfusionsmedizin, Herzzentrum NRW, Ruhr Universitat Bochum, Bad Oeynhausen, Germany
    Am J Clin Nutr 89:1321-7. 2009
    ..However, there is also evidence that calcitriol increases lipogenesis and decreases lipolysis...
  60. pmc Dietary supplement use in the United States, 2003-2006
    Regan L Bailey
    National Institutes of Health, Office of Dietary Supplements, Bethesda, MD 20892 7517, USA
    J Nutr 141:261-6. 2011
    ..Between 28 and 30% reported using dietary supplements containing vitamins B-6, B-12, C, A, and E; 18-19% reported using iron, selenium, and chromium; and 26-27% ..
  61. ncbi Systematic review: Vitamin D and calcium supplementation in prevention of cardiovascular events
    Lu Wang
    Brigham and Women s Hospital and Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Ann Intern Med 152:315-23. 2010
    ..Vitamin D and calcium may affect the cardiovascular system independently and interactively...
  62. ncbi Authors' perspective: What is the optimum intake of vitamin C in humans?
    Balz Frei
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Crit Rev Food Sci Nutr 52:815-29. 2012
    ....
  63. ncbi Systematic review of herbs and dietary supplements for glycemic control in diabetes
    Gloria Y Yeh
    Division for Research and Education in Complementary and Integrative Medical Therapies, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 26:1277-94. 2003
    ..To conduct a systematic review of the published literature on the efficacy and safety of herbal therapies and vitamin/mineral supplements for glucose control in patients with diabetes...
  64. ncbi Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety
    R Vieth
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Mount Sinai Hospital, Ontario, Canada
    Am J Clin Nutr 69:842-56. 1999
    ....
  65. ncbi Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988-1994
    Shanna Nesby-O'Dell
    Division of Nutrition and Physical Activity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta 30341 3717, USA
    Am J Clin Nutr 76:187-92. 2002
    ..African American women are at higher risk of vitamin D deficiency than are white women, but few studies have examined determinants of hypovitaminosis D in this population...
  66. pmc The nonskeletal effects of vitamin D: an Endocrine Society scientific statement
    Clifford J Rosen
    Tufts University School of Medicine, Boston, MA 02111, USA
    Endocr Rev 33:456-92. 2012
    ..Thus, at this time, more studies are needed to definitively conclude that vitamin D can offer preventive and therapeutic benefits across a wide range of physiological states and chronic nonskeletal disorders...
  67. ncbi Contrasting effects of Bifidobacterium breve NCIMB 702258 and Bifidobacterium breve DPC 6330 on the composition of murine brain fatty acids and gut microbiota
    Rebecca Wall
    Alimentary Pharmabiotic Centre, Biosciences Institute, University College Cork, Cork, Ireland
    Am J Clin Nutr 95:1278-87. 2012
    ..We previously showed that microbial metabolism in the gut influences the composition of bioactive fatty acids in host adipose tissue...
  68. ncbi Effects of n-3 fatty acids on macro- and microvascular function in subjects with type 2 diabetes mellitus
    Alin Stirban
    Ruhr University Bochum, Bochum, Germany
    Am J Clin Nutr 91:808-13. 2010
    ..Recent evidence supports the protective effects of n-3 (omega-3) fatty acids (n-3 FAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on vascular function...
  69. ncbi Implication of conjugated linoleic acid (CLA) in human health
    Allison Dilzer
    Department of Food Science, University of Massachusetts, Amherst, Amherst, MA 01003, USA
    Crit Rev Food Sci Nutr 52:488-513. 2012
    ..Along with a number of beneficial effects of CLA, there are safety considerations for CLA supplementation in humans, which include effects on liver functions, milk fat depression, glucose metabolism, and oxidative stresses...
  70. ncbi Can vitamin D deficiency cause diabetes and cardiovascular diseases? Present evidence and future perspectives
    G Muscogiuri
    Endocrinologia e Malattie del Metabolismo, Universita Cattolica, Rome, Italy
    Nutr Metab Cardiovasc Dis 22:81-7. 2012
    ....
  71. pmc Effects of vitamin D supplementation on cognitive and emotional functioning in young adults--a randomised controlled trial
    Angela J Dean
    Queensland Brain Institute, The University of Queensland, St Lucia, Australia
    PLoS ONE 6:e25966. 2011
    ..This study examined whether Vitamin D supplementation led to improvements in diverse measures of cognitive and emotional functioning, and hypothesised that supplementation would lead to improvements in these outcomes compared to placebo...
  72. ncbi The vitamin D status of Canadians relative to the 2011 Dietary Reference Intakes: an examination in children and adults with and without supplement use
    Susan J Whiting
    College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada
    Am J Clin Nutr 94:128-35. 2011
    ..The Canadian population has not yet been assessed according to these recommendations...
  73. ncbi Selenium: a double-edged sword for defense and offence in cancer
    Jela Brozmanová
    Laboratory of Molecular Genetics, Cancer Research Institute, Vlarska 7, 833 91, Bratislava, Slovak Republic
    Arch Toxicol 84:919-38. 2010
    ..Since Saccharomyces cerevisiae has proven a powerful tool for addressing some important questions regarding Se biology, a part of this review is devoted to this model system...
  74. ncbi Vitamin D: evolutionary, physiological and health perspectives
    Michael F Holick
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, MA, USA
    Curr Drug Targets 12:4-18. 2011
    ..It is estimated that 1 billion people worldwide are vitamin D deficient or insufficient. Correcting and preventing this deficiency could have an enormous impact on reducing health costs worldwide...
  75. ncbi Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells
    Mark Bouwens
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, 6703 HD Wageningen, Netherlands
    Am J Clin Nutr 90:415-24. 2009
    ..Polyunsaturated fatty acids can have beneficial effects on human immune cells, such as peripheral blood mononuclear cells (PBMCs). However, the mechanisms of action of polyunsaturated fatty acids on immune cells are still largely unknown...
  76. pmc Calcium and vitamin D supplements and health outcomes: a reanalysis of the Women's Health Initiative (WHI) limited-access data set
    Mark J Bolland
    Department of Medicine, University of Auckland, Auckland, New Zealand
    Am J Clin Nutr 94:1144-9. 2011
    ..Frequent use of personal, nonprotocol calcium supplements obscured an adverse effect of coadministered calcium and vitamin D (CaD) on cardiovascular risk in the Women's Health Initiative (WHI)...
  77. ncbi Vitamin D(3) is more potent than vitamin D(2) in humans
    Robert P Heaney
    Creighton University, 601 North 30th Street, Suite 4841, Omaha, Nebraska 68131, USA
    J Clin Endocrinol Metab 96:E447-52. 2011
    ..Current unitage for the calciferols suggests that equimolar quantities of vitamins D(2) (D2) and D(3) (D3) are biologically equivalent. Published studies yield mixed results...
  78. ncbi No effect of antioxidant supplementation on muscle performance and blood redox status adaptations to eccentric training
    Anastasios A Theodorou
    Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece
    Am J Clin Nutr 93:1373-83. 2011
    ..It was recently reported that antioxidant supplementation decreases training efficiency and prevents cellular adaptations to chronic exercise...
  79. ncbi beta-Alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters
    Wim Derave
    Dept of Movement and Sport Sciences, Ghent Univ, Watersportlaan 2, B 9000 Ghent, Belgium
    J Appl Physiol (1985) 103:1736-43. 2007
    ....
  80. ncbi Effects of prenatal food and micronutrient supplementation on infant development: a randomized trial from the Maternal and Infant Nutrition Interventions, Matlab (MINIMat) study
    Fahmida Tofail
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Am J Clin Nutr 87:704-11. 2008
    ..Few data exist for the effects of multiple micronutrient (MM) or food supplementation to undernourished pregnant women on their offsprings' development...
  81. ncbi Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity
    C A Hill
    School of Sports, Exercise and Health Sciences, University of Chichester, Chichester, UK
    Amino Acids 32:225-33. 2007
    ..0%); with a further +3.2% increase at 10 wks. TWD was unchanged at 4 and 10 wks in the control subjects. The increase in TWD with supplementation followed the increase in muscle carnosine...
  82. pmc Calcium plus vitamin D supplementation and the risk of breast cancer
    Rowan T Chlebowski
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    J Natl Cancer Inst 100:1581-91. 2008
    ..Although some observational studies have associated higher calcium intake and especially higher vitamin D intake and 25-hydroxyvitamin D levels with lower breast cancer risk, no randomized trial has evaluated these relationships...
  83. ncbi Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient - a randomised, placebo-controlled trial
    Pamela R von Hurst
    Institute of Food, Nutrition and Human Health, Massey University, Private Bag 102 904, North Shore Mail Centre, Auckland, New Zealand
    Br J Nutr 103:549-55. 2010
    ..Optimal vitamin D concentrations for reducing IR were shown to be 80-119 nmol/l, providing further evidence for an increase in the recommended adequate levels. Registered Trial No. ACTRN12607000642482...
  84. ncbi Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy?
    Brian D Lawenda
    Radiation Oncology Division, Breast Health Center, Naval Medical Center San Diego, San Diego, CA, USA
    J Natl Cancer Inst 100:773-83. 2008
    ....
  85. ncbi The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis
    R C Harris
    School of Sports, Exercise and Health Sciences, University College Chichester, West Sussex, Chichester, UK
    Amino Acids 30:279-89. 2006
    ..2 and II) 6.4 g . d(-1) beta-alanine (as multiple doses of 400 or 800 mg) or III) L-carnosine (isomolar to II) for 4 w resulted in significant increases in muscle carnosine estimated at 42.1, 64.2 and 65.8%...
  86. ncbi Lutein, zeaxanthin, and the macular pigment
    J T Landrum
    Department of Chemistry, Florida International University, Miami 33199, USA
    Arch Biochem Biophys 385:28-40. 2001
    ....
  87. ncbi A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly
    Christos S Katsanos
    Department of Surgery, University of Texas Medical Branch, Galveston, Texas 77550, USA
    Am J Physiol Endocrinol Metab 291:E381-7. 2006
    ..We conclude that increasing the proportion of leucine in a mixture of EAA can reverse an attenuated response of muscle protein synthesis in elderly but does not result in further stimulation of muscle protein synthesis in young subjects...
  88. ncbi Primary care-relevant interventions to prevent falling in older adults: a systematic evidence review for the U.S. Preventive Services Task Force
    Yvonne L Michael
    Epidemiology and Biostatistics, Drexel University School of Public Health, 1505 Race Street, 6th Floor, MS 1033, Philadelphia, PA 19102, USA
    Ann Intern Med 153:815-25. 2010
    ..Falls among older adults are both prevalent and preventable...
  89. ncbi Dietary supplements and team-sport performance
    David Bishop
    Institute of Sport, Exercise and Active Living ISEAL and School of Sport and Exercise Science, Victoria University, Melbourne, Victoria, Australia
    Sports Med 40:995-1017. 2010
    ..While a number of excellent reviews have evaluated the performance-enhancing effects of most dietary supplements, less attention has been paid to the performance-enhancing claims of dietary supplements in the context of ..
  90. ncbi Can oxidative damage be treated nutritionally?
    Mette M Berger
    Surgical ICU, Soins Intensifs Chirurgicaux et Centre des Brûlés, CHUV BH08 660, CH 1011 Lausanne, Switzerland
    Clin Nutr 24:172-83. 2005
    ..The beneficial effects have been attributed to the reduction of oxidative damage caused by the normal or excessive free radical production. The papers aims at collecting evidence of successful supplementation strategies...
  91. ncbi Assessing the vitamin D status of the US population
    Elizabeth A Yetley
    Office of Dietary Supplements, National Institutes of Health, Bethesda, MD, USA
    Am J Clin Nutr 88:558S-564S. 2008
    ..Children tend to have higher vitamin D status than adults. The increasing use of multivitamin-mineral dietary supplements in younger to older adults is not associated with a corresponding increase in serum 25(OH)D concentrations...
  92. pmc Dietary supplements and mortality rate in older women: the Iowa Women's Health Study
    Jaakko Mursu
    Department of Health Sciences, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, Finland
    Arch Intern Med 171:1625-33. 2011
    Although dietary supplements are commonly taken to prevent chronic disease, the long-term health consequences of many compounds are unknown.
  93. ncbi Prolonged n-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease: a pilot study
    M Capanni
    Nutrition Center and Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    Aliment Pharmacol Ther 23:1143-51. 2006
    ..However, data in humans are still lacking...
  94. ncbi Selenium supplementation, baseline plasma selenium status and incidence of prostate cancer: an analysis of the complete treatment period of the Nutritional Prevention of Cancer Trial
    A J Duffield-Lillico
    Arizona Cancer Center, Tucson, USA
    BJU Int 91:608-12. 2003
    ....
  95. ncbi Antioxidant supplementation during exercise training: beneficial or detrimental?
    Tina Tinkara Peternelj
    School of Human Movement Studies, The University of Queensland, Brisbane, QLD, Australia
    Sports Med 41:1043-69. 2011
    ..We recommend that an adequate intake of vitamins and minerals through a varied and balanced diet remains the best approach to maintain the optimal antioxidant status in exercising individuals...
  96. ncbi Selenoproteins and cancer prevention
    Cindy D Davis
    Nutritional Science Research Group, National Cancer Institute, Rockville, Maryland 20892, USA
    Annu Rev Nutr 32:73-95. 2012
    ....
  97. ncbi Vitamin D deficiency and supplementation and relation to cardiovascular health
    James L Vacek
    Mid America Cardiology, Division of Cardiovascular Medicine, University of Kansas Medical Center and Hospital, Kansas City, Kansas, USA
    Am J Cardiol 109:359-63. 2012
    ..Vitamin D supplementation was significantly associated with better survival, specifically in patients with documented deficiency...
  98. ncbi Folate and human reproduction
    Tsunenobu Tamura
    Department of Nutrition Sciences, University of Alabama at Birmingham, AL 35294, USA
    Am J Clin Nutr 83:993-1016. 2006
    ....
  99. pmc Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential
    Kate Petersen Shay
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Biochim Biophys Acta 1790:1149-60. 2009
    ..Current trials are investigating whether these beneficial properties of LA make it an appropriate treatment not just for diabetes, but also for the prevention of vascular disease, hypertension, and inflammation...
  100. pmc Antacids and dietary supplements with an influence on the gastric pH increase the risk for food sensitization
    I Pali-Schöll
    IPP Department of Pathophysiology, Centre of Physiology, Pathophysiology and Immunology, Medical University of Vienna, Vienna, Austria
    Clin Exp Allergy 40:1091-8. 2010
    ..This can be caused by acid-suppressing medication like sucralphate, H2-receptor blockers and proton pump inhibitors, as shown in recent murine experimental and human observational studies...
  101. pmc Efficacy of different doses and time intervals of oral vitamin D supplementation with or without calcium in elderly nursing home residents
    V Chel
    Verpleeghuis Marienhave, Warmond, The Netherlands
    Osteoporos Int 19:663-71. 2008
    ..A daily dose was more effective than a weekly dose, and a monthly dose was the least effective...

Research Grants76

  1. Formulation Dependent Help Interactions with Chemothera*
    David Kroll; Fiscal Year: 2005
    ..cancer pharmacology, drug metabolism, and interest in therapeutic natural products (prescription drugs and dietary supplements), preliminary work was conducted to investigate potential pharmacodynamic and pharmacokinetic interactions ..
  2. Novel Puerarin Analogs with Anti-Diabetic Activity
    NICHOLAS CAIRNS; Fiscal Year: 2007
    ..We have recently demonstrated that puerarin, the major isoflavone C-glucoside found in kudzu dietary supplements significantly improved glucose tolerance in C57BL/6J-ob/ob mice, an animal model of type 2 diabetes, ..
  3. Nitric oxide as a target for dietary intervention in colitis
    Michael Wargovich; Fiscal Year: 2007
    ..Use of alternative medicine is common in the United States and 40% of colitis suffers currently use dietary supplements. However, the scientific evidence for the use of alternative medicines is often lacking or weak, and ..
  4. Cardiovascular Effects of lyengar Yoga
    Raymond Townsend; Fiscal Year: 2006
    ..blood pressure, much of the research to date has been on dietary (low sodium) and activity advice, and dietary supplements (garlic, fish oils)...
  5. Ferritin and Iron Nutrition in Health and Disease
    Elizabeth Theil; Fiscal Year: 2005
    ..The results will clarify mechanisms of ferritin iron uptake and characterize molecular genetic differences in iron uptake for improving dietary iron sources in health and disease. ..
  6. Hepcidin-based screening for infantile iron deficiency
    Mark D Fleming; Fiscal Year: 2010
    ..Because of the ease of correcting ID with dietary supplements and the imperative to identify an early ID (EID) state before anemia develops, when children are ..
  7. Mechanism of action of omega-3 fatty acids in brain injury
    CHARLES NICHOLAS SERHAN; Fiscal Year: 2010
    ..provided by applicant): Public interest has resulted in increased consumption of omega-3 fatty acids as dietary supplements (derived mainly from fish-oil) based upon purported effects that include: reduction in cardiovascular ..
  8. The mechanisms by which alcohol and HIV render the lung susceptible to injury
    DAVID MARSHALL GUIDOT; Fiscal Year: 2013
    ..this project may help us improve the health of these vulnerable individuals with relatively simple dietary supplements such as zinc, either alone or in combination with thiol anti-oxidants such as S- adenosylmethionine that ..
  9. Dietary Supplement Creatine for Adolescent Females with SSRI-Resistant Depression
    PERRY FRANKLIN RENSHAW; Fiscal Year: 2013
    ..strategies outlined in the strategic plans of the National Institute of Mental Health and the Office of Dietary Supplements. The long-term goal of this research program is to delineate the alterations in mitochondrial brain energy ..
  10. Role of natural indoles in experimental autoimmune encephalomyelitis
    Mitzi Nagarkatti; Fiscal Year: 2013
    ..The current study investigates the mechanism of action of plant-derived indoles used as dietary supplements, specifically addressing the role of AhR activation in the regulation of inflammation...
  11. Tea Polyphenols in Chemoprevention of Prostate Cancer
    SUSANNE MARGARETE HENNING; Fiscal Year: 2011
    ..The results will assist in designing dietary supplements for chemoprevention of early stages of prostate cancer or during watchful waiting.
  12. Chemoprevention of Tamoxifen-induced Endometrial cancer by black cohosh and red c
    BIRGIT MARIA DIETZ; Fiscal Year: 2010
    ..In tamoxifen treated patients, botanical dietary supplements such as red clover and black cohosh extracts are frequently used for the alleviation of tamoxifen related ..
  13. ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION (ADME) IN MAMMALS
    Jacob McDonald; Fiscal Year: 2013
    ..Humans may be exposed to BMAA from consuming blue-green algae dietary supplements and foods and/or water containing the chemical...
  14. Memory and Mood Enhancing Therapies for Gulf War Illness
    Ashok K Shetty; Fiscal Year: 2013
    ..of an anti-depressant drug (FLU or ROL) and an antioxidant drug (Curcumin [CUR] or Resveratrol [RESV];dietary supplements having anti-oxidant, anti-inflammatory, and neurogenesis enhancing properties) greatly enhance hippocampal ..
  15. MECHANISMS OF CHONDROPROTECTION BY POMEGRANATE FRUIT EXTRACT
    Tariq M Haqqi; Fiscal Year: 2011
    ..the use of herbal extracts for the treatment of OA is on the rise but most of these agents, sold as dietary supplements, have not been evaluated for their efficacy and safety...
  16. ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION (ADME) IN MAMMALS
    Jacob McDonald; Fiscal Year: 2012
    ..Potential human exposure to this is possible via consumption of blue-green algae dietary supplements and other food supplies. Exposure of BMAA in rats exhibited neurotoxicity...
  17. Phase 1 Study of Quercetin for the Treatment of Fanconi Anemia
    Parinda Mehta; Fiscal Year: 2013
    ..Quercetin is a naturally occurring anti-oxidant, found in the normal diet, and dietary supplements/multivitamin preparations...
  18. Omega-3 Fatty Acids &Psychoeducational Psychotherapy for Childhood Depression
    Mary A Fristad; Fiscal Year: 2013
    ..These worries have prompted interest in alternative therapies including dietary supplements, in particular, omega-3 fatty acids (?3)...
  19. Reactivation of Tumor Suppressor Genes in Breast Cancer by Dietary Supplements as
    Zhongfa Liu; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Reactivation of Tumor Suppressor Genes in Breast Cancer by Dietary Supplements Hypermethylation-silenced tumor suppressor gene (TSG) is a hallmark of most cancers, including breast cancer and has ..
  20. Prolongation of lifespan by n-3 fatty acids and calorie restriction
    GABRIEL J FERNANDES; Fiscal Year: 2010
    The use of n-3 fatty acids (n-3 FA) from fish oil as dietary supplements to protect against inflammatory disorders is recently on the rise by the general public in US...
  21. OMEGA-3 SUPPLMENTATION DECREASES INFLAMMATION AND FETAL OBESITY IN PREGNANCY
    Sylvie Hauguel De Mouzon; Fiscal Year: 2010
    ..Therefore, we hypothesize that n-3 PUFA dietary supplements during pregnancy witl act as insulin sensitizers decreasing peripheral insulin resistance and inflammation...
  22. DETERMINANTS OF MALE AND FEMALE FECUNDITY AND FERTILITY-DATA COORDINATING CENTER
    Edward Clark; Fiscal Year: 2009
    ..approximately 20 ml of blood for the analysis of HAAs and metabolites of cigarette smoke, caffeine, and dietary supplements. Male partners provided semen samples for an objective assessment of male fecundity...
  23. Prostate cancer prevention by tocopherols
    Ah Ng Tony Kong; Fiscal Year: 2013
    ..to determine if one or both of these cancer chemopreventive substances can help prevent PCa when taken as dietary supplements. The recently published results indicated that selenium (200 [unreadable]g/d) and vitamin E (400 IU/d, (-T),..
  24. Ginger Extracts in the Prevention of Metabolic Bone Disease
    LAURA ELIZABETH WRIGHT; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Herbs and dietary supplements are among the most commonly used complementary or alternative medical (CAM) therapies in the United States...
  25. Gene Expression Effect of Antioxidant Supplementation on Epithelium of Lung:ExSEL
    Patricia A Cassano; Fiscal Year: 2010
    ..also seeks to understand whether a person's body level of antioxidants, which can be modified by dietary supplements, is related to severity of disease in Chronic Obstructive Pulmonary Disease (COPD) patients...
  26. Field Validation of New XRF Analyzers: Assessing Personal Exposure to Metals
    PATRICK JEREMY PARSONS; Fiscal Year: 2012
    ..as well as samples of food or ingestible material (spices, nuts, dietary supplements, pills, etc.) that can be easily crushed, powdered, or homogenized...
  27. The Impact of Maternal Health and Diet on Development of Fetal Metabolic Systems
    KENT L R THORNBURG; Fiscal Year: 2013
    ..It will also be determined if dietary supplements with either fish oil or resveratrol, to prevent inflammation, oxidative stress, will provide similar ..
  28. Antitumor and chemopreventive activity of the Ecuadorian plant extract BIRM
    Bal L Lokeshwar; Fiscal Year: 2010
    Patients with malignant diseases commonly consume poorly characterized medicine or dietary supplements. Extensive use of untested formulations, provide both opportunities and danger...
  29. Molecular mechanism of omega-3 response
    JAMES T BRENNA; Fiscal Year: 2013
    ..g., 22:6n-3, 20:5n-3) are among the most popular dietary supplements used by Americans...
  30. Curcuma Longa: epigenetic effects in prostate and colon cancer
    Ah Ng Tony Kong; Fiscal Year: 2013
    ..CUR;~77%), demethoxycurcumin (~17%) and bis-demethoxycurcumin (~3%), they are commonly used as botanical dietary supplements. The long term goal of this research project is to develop a safe and effective strategy to use C.L...
  31. Prevention of estrogen-mediated mammary carcinogenesis by mixtures of tocopherols
    Nanjoo Suh; Fiscal Year: 2013
    ..Tocopherols are commonly occurring in vegetable oils and readily available as dietary supplements. Understanding the effects of naturally occurring tocopherol mixtures and individual tocopherols and ..
  32. Role of a Novel E3-Ubiquitin Ligase in Chemoprevention
    Mark Hannink; Fiscal Year: 2009
    ..fundamental understanding of this signal transduction pathway will facilitate the identification of foods, dietary supplements and drugs that will significantly decrease the risk of cancer in humans...
  33. Identification of novel phytoprogestins from hops and red clover
    Joanna E Burdette; Fiscal Year: 2011
    ..In response to the problems associated with HRT, millions of women are exploring the use of botanicals and dietary supplements for the alleviation of climacteric symptoms...
  34. MAM'Out project: evaluation of innovative approaches to prevent acute malnutritio
    Patrick Kolsteren; Fiscal Year: 2013
    ..The total length of the project is 3.5 years, with 2 years of direct interventions and measurements in the field. ..
  35. International Population Study on Macronutrients and BP - INTERMAP
    LINDA VERNER VAN HORN; Fiscal Year: 2013
    ..from four in-depth multi-pass 24-hour dietary recalls/person with computerization of all reported foods/ dietary supplements classified into 23 groups and 119 subgroups, their conversion into nutrients (total: 83);two timed 24-hour ..
  36. The Wake Forest Center for Botanical Lipids and Inflammatory Disease Prevention
    Floyd H Chilton; Fiscal Year: 2013
    ..A secondary hypothesis is that that the metabolism and effectiveness of PUFA-based botanical dietary supplements is strongly associated with genetic polymorphisms in the fatty acid desaturase (FADS 1-3) cluster on ..
  37. N-Acetyl Cysteine plus Behavioral Therapy for Nicotine Dependent Pathological Gam
    Jon E Grant; Fiscal Year: 2010
    ..Behavioral Change and Prevention and specific Challenge Topic, 01-DA-110: Identify and/or evaluate dietary supplements that could be used in treating substance use disorders. Among US adults, 12...
  38. Curcumin and Quercetin in Colon Cancer: Role of Macrophage-Induced Inflammation
    ELIZABETH ANGELA MURPHY; Fiscal Year: 2010
    ..While a number of studies have examined the effects of dietary supplements on inflammation in cancer, none have specifically examined the role of tissue macrophages (Ms), primary ..
  39. Biomarkers of Oxidative Stress in Parkinson's Disease
    M Flint Beal; Fiscal Year: 2010
    ..and validation of biomarkers of oxidative stress that could be used to assess the antioxidant effects of dietary supplements in vivo...
  40. Mu Center for Botanical Interaction Studies
    Dennis B Lubahn; Fiscal Year: 2013
    ..Pathways to Prevent Prostate Cancer will test the hypothesis that five individual, widely-used botanical dietary supplements will prevent prostate cancer through the five key signaling pathways...
  41. mtDNA mutation/heteroplasmy: a sensitive functional biomarker of oxidative stress
    Bruce N Ames; Fiscal Year: 2010
    ..by applicant): Many biomarkers are responsive to oxidative stress and modulating effects of antioxidant dietary supplements, but the disease relevance of these markers is uncertain because of the lack of known functional or ..
  42. The 50th Annual Meeting of the American Society of Pharmacognosy
    Bill J Baker; Fiscal Year: 2010
    ..including Antitumor Natural Products/Cancer Chemoprevention, Modern Analytical Techniques, Botanicals/Dietary Supplements/Phytomedicines, Diabetes, Digestive and Kidney Diseases (Session in honor of John Daly), Marine Natural ..
  43. Novel multivalent vaccine for anthrax and botulinum
    Mansour Mohamadzadeh; Fiscal Year: 2013
    ..new generation of harmless immunostimulatory bacteria called Lactobacillus gasseri that can be ingested as dietary supplements. Our data show that L...
  44. Michigan Hepatotoxicity Clinical Research Network Renewal 2013
    Robert J Fontana; Fiscal Year: 2013
    ..In addition, 1215 patients with liver injuy attributed to over 100 individual drugs and herbal and dietary supplements (HDS) have been enrolled and followed for at least 6 months in the ongoing DILIN Prospective study...
  45. Resveratrol for Enriching Neurogenesis &Memory in the Aged
    Ashok K Shetty; Fiscal Year: 2011
    ..In this context, identification of safe dietary supplements that have the ability to stimulate the quiescent NSCs to produce new neurons in the aged hippocampus has ..
  46. Biomodification of Dentin Matrix Structure
    Ana Karina B Bedran-Russo; Fiscal Year: 2013
    ..used as natural antioxidants and have proven to be safe in various clinical applications and in herbal dietary supplements. This multidisciplinary project will focus on the biochemistry and biomechanics involved in the multi-..
  47. Diet and Exercise (DE) Program for Alzheimer Prevention
    SALLY ANN FRAUTSCHY; Fiscal Year: 2010
    ..success, this project aims to develop a cheap, safe and effective prevention method with over the counter dietary supplements combined with exercise to prevent Alzheimer's and to show that efficacy with our approach in people ..
  48. Maternal epigenetic dietary effects on early breast cancer prevention
    PHILLIP JOE BUCKHAULTS; Fiscal Year: 2013
    ..breast cancer chemopreventive potential by appropriate administration of prenatal and/or postnatal dietary supplements leading to early breast cancer prevention...
  49. Role of LITAF in Inflammatory Disease
    Salomon Amar; Fiscal Year: 2013
    ..The screening library, comprising in part dietary supplements and established nutraceuticals, contained at least one class of natural products that displayed TNF-[..
  50. Determining Epigenetic Targets of Milk Thistle Extract in Prostate
    Maureen K Bunger; Fiscal Year: 2010
    ..By identifying these alleles and understanding their epigenetic heterogeneity in a normal tissue, we advance our understanding of how dietary supplements such as silibinin exert their effects on prostate tissue over the long term.
  51. Research Training: Complementary &Integrative Medicine
    Gloria Y Yeh; Fiscal Year: 2013
    ..yoga, tai chi, meditation, and placebo phenomenon), Asian medicine (including acupuncture and Ayurveda) and dietary supplements (including botanicals), all areas of faculty expertise...
  52. Efficacy of Turmeric Extract in Prevention of Post-menopausal Osteoporosis
    Janet Funk; Fiscal Year: 2009
    ..Evidence obtained here supporting (or refuting) the efficacy of turmeric dietary supplements in osteoporosis prevention and/or treatment will (1) begin to help guide the public's use of turmeric ..
  53. "Mount Sinai Regional Drug Induced Liver Injury Network Site"
    JOSEPH ODIN; Fiscal Year: 2013
    ..nature, variable presentation, and the vast number of potential causative drugs as well as herbal and dietary supplements, drug-induced liver injury (DILI) is often diagnosed late in its course when patients present with severe ..
  54. Prevention of temporary hearing loss with AuraQuell
    PETER BOXER; Fiscal Year: 2009
    ..OtoMedicine Inc. has identified a proprietary combination of dietary supplements called AuraQuell", which is highly effective in preventing permanent noise-induced hearing loss (NIHL) and ..
  55. Identification of Natural Product Inhibitors of Breast Cancer Bone Metastasis
    Janet L Funk; Fiscal Year: 2012
    ..and spread of breast cancer bone metastases by blockade of tumor cell PTHrP expression, their use as dietary supplements could prove to be useful additions to adjuvant treatment options in women diagnosed with early breast ..
  56. Fatty Liver Preventive Effects and High Dose Hepatotoxicity of Tea Polyphenols
    Joshua D Lambert; Fiscal Year: 2013
    ..Recently, green tea polyphenols have been used as dietary supplements for weight reduction, however, the efficacy of such preparations remains debatable...
  57. Xanthohumol and Metabolic Syndrome
    Jan Frederik Stevens; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Thousands of Americans are taking dietary supplements containing xanthohumol (XN), a prenylflavonoid from hops (Humulus lupulus), for improving general health, ..
  58. Oral microbial enzymes for the treatment of celiac disease
    EVA JOSEPHINE HELMERHORST; Fiscal Year: 2013
    ..A promising therapeutic approach is the use of enzymes as dietary supplements to achieve gluten degradation and detoxification in vivo...
  59. Carbohydrate Deficient Glycoprotein Syndromes: Models and Therapy
    Hudson H Freeze; Fiscal Year: 2013
    ..However, dietary supplements of mannose bypass the defect by increasing the flux of Mannose through a minor biosynthetic pathway (Man`..
  60. Estrogen Receptor-beta phytoSERMs for Management of Menopause and Memory Decline
    Lon S Schneider; Fiscal Year: 2012
    ..Given that soy isoflavone extracts are available as dietary supplements, and that the compounds are 'generally recognized as safe'(GRAS, under FDA regulations), we ..
  61. Academic Career Award in Complementary and Alternative Medicine
    PAULA MARIE GARDINER; Fiscal Year: 2013
    ..National Health Interview Survey reports that approximately one in five adults use Herbs and non-vitamin Dietary Supplements (HDS)...
  62. Novel 13-C Tomato Carotenoids for Absorption and Metabolism Studies in Humans
    Steven K Clinton; Fiscal Year: 2012
    ..and Alternative Medicine (NCCAM), NCI, the National Institute on Aging (NIA), and the Office of Dietary Supplements (ODS)...
  63. Novel Combinations of Foods Targeting Prostate Cancer Prevention
    KRYSTLE ERIN ZUNIGA; Fiscal Year: 2012
    ..amount of research on bioactives and functional foods has fueled the development and marketing of foods and dietary supplements for prostate health, including both soy and tomato phytochemicals, and men may consume combinations of ..
  64. CONTROLLING NK CELL ANTI-CANCER ACTIVITY: THE ROLE OF NUTRIENTS AND SUPPLEMENTS
    Marco Colonna; Fiscal Year: 2013
    ..We hypothesize that by engaging AHR through dietary supplements, we can manipulate the numbers and or the activity of NK-22...
  65. DRUG METABOLISM BY INTESTINAL FLAVIN MONOOXYGENASES
    ROSITA PROTEAU; Fiscal Year: 2001
    ..interaction is an everyday occurrence whether the interaction is with flavonoids from food, juice, or dietary supplements. This is especially likely when consumption of flavonoids is encouraged for their health benefits...
  66. Botanical Dietary Supplements for Women's Health
    Richard B van Breemen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The UIC/NIH Center for Botanical Dietary Supplements Research ("UIC/NIH Botanical Center" and "Center") was established in the fall of 1999 to address issues of standardization, quality, safety and ..
  67. Spectrometric Validation of Botanical Materials and Reference Standards
    Guido F Pauli; Fiscal Year: 2010
    ..This concise summary fully characterizes the current situation of botanical dietary supplements (botanicals), which represent natural health products that are widely sold to and consumed by the U.S...
  68. Drug-Dietary Flavonoid Intestinal Absorption Interaction
    ROSITA PROTEAU; Fiscal Year: 2002
    ..for drug-dietary interaction is an everyday occurrence whether the interaction is with food, juice, or dietary supplements. Moreover, the consumption of flavonoids is being urged because of their multiple health benefits; thus, ..
  69. ARIZONA CENTER FOR PHYTOMEDICINE RESEARCH (ACPRX)
    Janet Funk; Fiscal Year: 2004
    DESCRIPTION (Applicant's Abstract): The use of dietary supplements containing botanical products is rapidly expanding in the United States...
  70. Serotonergic Botanicals for Menopausal Treatment
    SHARLA POWELL; Fiscal Year: 2009
    ..As a result, in recent years, a growing interest in botanical dietary supplements has occurred;however, in most cases the efficacy of these supplements lack scientific evidence thus ..
  71. Phase II Construction of NCNPR Research Wing
    Larry A Walker; Fiscal Year: 2010
    ..scientific basis for enhancement of the authentication, quality and safety of botanical products used as dietary supplements in the US...
  72. NUTRITIONAL PREVENTION OF POLYPS IN THE LARGE BOWEL
    Edward Bresnick; Fiscal Year: 1992
    This is a proposal to continue and conclude a randomized, double-blind clinical trial of the efficacy of dietary supplements in preventing neoplastic polyps (adenomas) of the colorectum in persons at high risk for this condition, It is a ..
  73. 2012 International Congress on Natural Products Conference
    Edward J Kennelly; Fiscal Year: 2012
    ..compounds and mixtures produced by organisms) many of which have been found useful as to therapeutics and dietary supplements. The objective of such a conference to disseminate recent research advances in natural products and related ..
  74. Enzyme & Receptor Antagonists of GHB, GBL & 1, 4-BD
    Lawrence Quang; Fiscal Year: 2003
    ..This designation imposes no legal restrictions on the manufacture, distribution (in dietary supplements), or possession of 1,4-BD...
  75. Dietary lignan effects on hormone, growth, and signaling factors in breast tumors
    Susan McCann; Fiscal Year: 2009
    ..is unclear whether amounts consumed via diet produce the same effects as pharmacologic doses available as dietary supplements. Elucidation of the effects of a wide range of phytoestrogen levels is necessary to adequately understand ..
  76. Molecular mechanisms of Angelica sinensis (Oliv.) Diels in women?s health
    Zaijie Jim Wang; Fiscal Year: 2010
    ..Instead, many women have turned to botanical dietary supplements. Angelica sinensis (Oliv...