tea

Summary

Summary: The infusion of leaves of CAMELLIA SINENSIS (formerly Thea sinensis) as a beverage, the familiar Oriental tea, which contains CATECHIN (especially epigallocatechin gallate) and CAFFEINE.

Top Publications

  1. ncbi Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions
    Jane V Higdon
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Crit Rev Food Sci Nutr 43:89-143. 2003
  2. pmc Deep sequencing of the Camellia sinensis transcriptome revealed candidate genes for major metabolic pathways of tea-specific compounds
    Cheng Ying Shi
    Key Laboratory of Tea Biochemistry and Biotechnology, Ministry of Education, Ministry of Agriculture, Anhui Agricultural University, Hefei, 230036, PR China
    BMC Genomics 12:131. 2011
  3. pmc Anti-infective properties of epigallocatechin-3-gallate (EGCG), a component of green tea
    J Steinmann
    Institute of Medical Microbiology, University Hospital Essen, University of Duisburg Essen, Essen, Germany
    Br J Pharmacol 168:1059-73. 2013
  4. pmc Cancer prevention by tea: animal studies, molecular mechanisms and human relevance
    Chung S Yang
    Susan Lehman Cullman Laboratory of Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Nat Rev Cancer 9:429-39. 2009
  5. ncbi Long-term administration of green tea catechins improves spatial cognition learning ability in rats
    Abdul M Haque
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo 693 8501, Japan
    J Nutr 136:1043-7. 2006
  6. ncbi Green tea (-)-epigallocatechin-3-gallate reduces body weight with regulation of multiple genes expression in adipose tissue of diet-induced obese mice
    Mak Soon Lee
    Department of Nutritional Science and Food Management, Ewha Womans University, Seoul, Korea
    Ann Nutr Metab 54:151-7. 2009
  7. pmc Anti-inflammatory and anti-oxidative effects of the green tea polyphenol epigallocatechin gallate in human corneal epithelial cells
    Megan E Cavet
    Global Pharmaceutical R and D, Bausch Lomb, Rochester, NY 14609, USA
    Mol Vis 17:533-42. 2011
  8. ncbi Antioxidant activity of tea polyphenols in vivo: evidence from animal studies
    Balz Frei
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    J Nutr 133:3275S-84S. 2003
  9. pmc Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms
    Joi A Nichols
    Department of Dermatology, University of Alabama at Birmingham, 1670 University Boulevard, Volker Hall 557, PO Box 202, Birmingham, AL 35294, USA
    Arch Dermatol Res 302:71-83. 2010
  10. ncbi Inhibition of carcinogenesis by tea
    Chung S Yang
    Laboratory for Cancer Research, Department of Chemical Biology, College of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 8020, USA
    Annu Rev Pharmacol Toxicol 42:25-54. 2002

Detail Information

Publications314 found, 100 shown here

  1. ncbi Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions
    Jane V Higdon
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Crit Rev Food Sci Nutr 43:89-143. 2003
    Increasing interest in the health benefits of tea has led to the inclusion of tea extracts in dietary supplements and functional foods...
  2. pmc Deep sequencing of the Camellia sinensis transcriptome revealed candidate genes for major metabolic pathways of tea-specific compounds
    Cheng Ying Shi
    Key Laboratory of Tea Biochemistry and Biotechnology, Ministry of Education, Ministry of Agriculture, Anhui Agricultural University, Hefei, 230036, PR China
    BMC Genomics 12:131. 2011
    b>Tea is one of the most popular non-alcoholic beverages worldwide. However, the tea plant, Camellia sinensis, is difficult to culture in vitro, to transform, and has a large genome, rendering little genomic information available...
  3. pmc Anti-infective properties of epigallocatechin-3-gallate (EGCG), a component of green tea
    J Steinmann
    Institute of Medical Microbiology, University Hospital Essen, University of Duisburg Essen, Essen, Germany
    Br J Pharmacol 168:1059-73. 2013
    The consumption of green tea (Camellia sinensis) has been shown to have many physiological and pharmacological health benefits...
  4. pmc Cancer prevention by tea: animal studies, molecular mechanisms and human relevance
    Chung S Yang
    Susan Lehman Cullman Laboratory of Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Nat Rev Cancer 9:429-39. 2009
    Extracts of tea, especially green tea, and tea polyphenols have been shown to inhibit the formation and development of tumours at different organ sites in animal models...
  5. ncbi Long-term administration of green tea catechins improves spatial cognition learning ability in rats
    Abdul M Haque
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo 693 8501, Japan
    J Nutr 136:1043-7. 2006
    Green tea catechins confer potent biological properties including antioxidation and free-radical scavenging...
  6. ncbi Green tea (-)-epigallocatechin-3-gallate reduces body weight with regulation of multiple genes expression in adipose tissue of diet-induced obese mice
    Mak Soon Lee
    Department of Nutritional Science and Food Management, Ewha Womans University, Seoul, Korea
    Ann Nutr Metab 54:151-7. 2009
    ..The aim of this study was to investigate the antiobesity effect of (-)-epigallocatechin-3-gallate (EGCG) in diet-induced obese mice...
  7. pmc Anti-inflammatory and anti-oxidative effects of the green tea polyphenol epigallocatechin gallate in human corneal epithelial cells
    Megan E Cavet
    Global Pharmaceutical R and D, Bausch Lomb, Rochester, NY 14609, USA
    Mol Vis 17:533-42. 2011
    To determine the anti-inflammatory and anti-oxidant effects of epigallocatechin gallate (EGCG), the major polyphenol component of green tea, in human corneal epithelial cells (HCEpiC).
  8. ncbi Antioxidant activity of tea polyphenols in vivo: evidence from animal studies
    Balz Frei
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    J Nutr 133:3275S-84S. 2003
    b>Tea is particularly rich in polyphenols, including catechins, theaflavins and thearubigins, which are thought to contribute to the health benefits of tea...
  9. pmc Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms
    Joi A Nichols
    Department of Dermatology, University of Alabama at Birmingham, 1670 University Boulevard, Volker Hall 557, PO Box 202, Birmingham, AL 35294, USA
    Arch Dermatol Res 302:71-83. 2010
    ..This review article summarizes the photoprotective effects of some selected polyphenols, such as green tea polyphenols, grape seed proanthocyanidins, resveratrol, silymarin and genistein, on UV-induced skin inflammation, ..
  10. ncbi Inhibition of carcinogenesis by tea
    Chung S Yang
    Laboratory for Cancer Research, Department of Chemical Biology, College of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 8020, USA
    Annu Rev Pharmacol Toxicol 42:25-54. 2002
    b>Tea has received a great deal of attention because tea polyphenols are strong antioxidants, and tea preparations have inhibitory activity against tumorigenesis...
  11. pmc The tea catechin epigallocatechin gallate suppresses cariogenic virulence factors of Streptococcus mutans
    Xin Xu
    Department of Pediatric Dentistry, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA
    Antimicrob Agents Chemother 55:1229-36. 2011
    ..The anticariogenic properties of tea have been suggested in experimental animals and humans...
  12. ncbi Beneficial effects of green tea--a review
    Carmen Cabrera
    Departamento de Nutricion y Bromatologia, Facultad de Farmacia, Campus Universitario de Granada, Granada, Spain
    J Am Coll Nutr 25:79-99. 2006
    b>Tea is the most consumed drink in the world after water. Green tea is a 'non-fermented' tea, and contains more catechins, than black tea or oolong tea. Catechins are in vitro and in vivo strong antioxidants...
  13. pmc Tea and cardiovascular disease
    Apranta Deka
    Evans Department of Medicine and the Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, United States
    Pharmacol Res 64:136-45. 2011
    There is increasing evidence for a protective effect of tea consumption against cardiovascular disease. This review summarizes the available epidemiological data providing evidence for and against such an effect...
  14. pmc Tea polyphenols for health promotion
    Naghma Khan
    Department of Dermatology, University of Wisconsin Madison, Medical Sciences Center, Madison, WI 53706, USA
    Life Sci 81:519-33. 2007
    People have been consuming brewed tea from the leaves of the Camellia sinensis plant for almost 50 centuries...
  15. pmc Caffeinated and decaffeinated coffee and tea intakes and risk of colorectal cancer in a large prospective study
    Rashmi Sinha
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD, USA
    Am J Clin Nutr 96:374-81. 2012
    Coffee and tea are widely consumed globally and are rich sources of potential chemopreventive compounds. Epidemiologic data for coffee and tea intakes in relation to colorectal cancer remain unclear...
  16. ncbi Oral consumption of green tea polyphenols inhibits insulin-like growth factor-I-induced signaling in an autochthonous mouse model of prostate cancer
    Vaqar Mustafa Adhami
    Department of Dermatology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Cancer Res 64:8715-22. 2004
    We earlier demonstrated that oral infusion of green tea polyphenols inhibits development and progression of prostate cancer in transgenic adenocarcinoma of the mouse prostate (TRAMP) model...
  17. ncbi Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor
    Glenn S Van Aller
    Department of Cancer Research, GlaxoSmithKline, Collegeville, PA 19426, USA
    Biochem Biophys Res Commun 406:194-9. 2011
    ..In this study, we show that (-)-epigallocatechin-3-gallate (EGCG), a major component of green tea, is an ATP-competitive inhibitor of both phosphoinositide-3-kinase (PI3K) and mammalian target of rapamycin (mTOR) ..
  18. ncbi Coffee, decaffeinated coffee, and tea consumption in relation to incident type 2 diabetes mellitus: a systematic review with meta-analysis
    Rachel Huxley
    The George Institute for International Health, The University of Sydney, Australia
    Arch Intern Med 169:2053-63. 2009
    ..Similar associations have also been reported for decaffeinated coffee and tea. We report herein the findings of meta-analyses for the association between coffee, decaffeinated coffee, and tea ..
  19. pmc Limitations of MTT and MTS-based assays for measurement of antiproliferative activity of green tea polyphenols
    Piwen Wang
    Center for Human Nutrition, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e10202. 2010
    The chemopreventive effect of green tea polyphenols, such as (-)-epigallocatechin-3-gallate (EGCG), has been well demonstrated in cell culture studies...
  20. ncbi Green tea epigallocatechin-3-gallate mediates T cellular NF-kappa B inhibition and exerts neuroprotection in autoimmune encephalomyelitis
    Orhan Aktas
    Institute of Neuroimmunology, Neuroscience Research Center, Charite, Berlin, Germany
    J Immunol 173:5794-800. 2004
    ..We show that the major green tea constituent, (-)-epigallocatechin-3-gallate (EGCG), dramatically suppresses EAE induced by proteolipid protein 139-..
  21. ncbi Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice
    Kavon Rezai-Zadeh
    Silver Child Development Center, Department of Psychiatry and Behavioral Medicine, University of South Florida, Tampa, Florida 33613, USA
    J Neurosci 25:8807-14. 2005
    ..Recent studies suggest that green tea flavonoids may be used for the prevention and treatment of a variety of neurodegenerative diseases...
  22. ncbi Antiviral effect of catechins in green tea on influenza virus
    Jae Min Song
    Department of Biotechnology, College of Engineering, Yonsei University, 134, Shinchon dong, Seodaemun gu, Seoul 120 749, South Korea
    Antiviral Res 68:66-74. 2005
    ..epigallocatechin gallate (EGCG), (-)-epicatechin gallate (ECG) and (-)-epigallocatechin (EGC)) from green tea were evaluated for their ability to inhibit influenza virus replication in cell culture and for potentially direct ..
  23. ncbi Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study
    Saverio Bettuzzi
    Department of Medicina Sperimentale, Sezione di Biochimica, University of Parma, Via Volturno 39, 43100 Parma, Italy
    Cancer Res 66:1234-40. 2006
    Green tea catechins (GTCs) proved to be effective in inhibiting cancer growth in several experimental models...
  24. ncbi Effect of green tea supplementation on insulin sensitivity in Sprague-Dawley rats
    Liang Yi Wu
    Graduate Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan
    J Agric Food Chem 52:643-8. 2004
    Epidemiological observations and laboratory studies have shown that green tea has a variety of health effects, including antitumor, antioxidative, and hypolipidemic activities...
  25. pmc The antioxidant and pro-oxidant activities of green tea polyphenols: a role in cancer prevention
    Joshua D Lambert
    Department of Food Science, The Pennsylvania State University, University Park, PA 16802, USA
    Arch Biochem Biophys 501:65-72. 2010
    Green tea (Camellia sinensis) is rich in catechins, of which (-)-epigallocatechin-3-gallate (EGCG) is the most abundant...
  26. pmc Tea, coffee, carbonated soft drinks and upper gastrointestinal tract cancer risk in a large United States prospective cohort study
    J S Ren
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States
    Eur J Cancer 46:1873-81. 2010
    The authors investigated the relationship between hot tea, iced tea, coffee and carbonated soft drinks consumption and upper gastrointestinal tract cancers risk in the NIH-AARP Study...
  27. pmc Green tea polyphenol EGCG suppresses lung cancer cell growth through upregulating miR-210 expression caused by stabilizing HIF-1α
    Hong Wang
    Susan L Cullman Laboratory for Cancer Research, Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy at Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Carcinogenesis 32:1881-9. 2011
    ..In summary, our results demonstrated, for the first time, the elevation of miR-210 by EGCG in lung cancer cell lines and this is mediated by the stabilization of HIF-1α. This event contributes to the anticancer activity of EGCG...
  28. pmc Risk of colon cancer and coffee, tea, and sugar-sweetened soft drink intake: pooled analysis of prospective cohort studies
    Xuehong Zhang
    Department of Nutrition, Department of Epidemiology, Harvard School of Public Health, 655 Huntington Ave, Boston, MA 02115, USA
    J Natl Cancer Inst 102:771-83. 2010
    The relationships between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk remain unresolved.
  29. ncbi Green tea and green tea catechin extracts: an overview of the clinical evidence
    Rachel Johnson
    Centre for Academic Primary Care, NIHR School for Primary Care Research, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
    Maturitas 73:280-7. 2012
    b>Tea leaves contain varying amounts of polyphenols of which the majority are catechins...
  30. ncbi Overview of antibacterial, antitoxin, antiviral, and antifungal activities of tea flavonoids and teas
    Mendel Friedman
    Western Regional Research Center, Agricultural Research Service, United States Department of Agriculture, Albany, CA, USA
    Mol Nutr Food Res 51:116-34. 2007
    b>Tea leaves produce organic compounds that may be involved in the defense of the plants against invading pathogens including insects, bacteria, fungi, and viruses...
  31. pmc Green tea polyphenols causes cell cycle arrest and apoptosis in prostate cancer cells by suppressing class I histone deacetylases
    Vijay S Thakur
    Department of Urology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    Carcinogenesis 33:377-84. 2012
    Green tea polyphenols (GTPs) reactivate epigenetically silenced genes in cancer cells and trigger cell cycle arrest and apoptosis; however, the mechanisms whereby these effects occur are not well understood...
  32. ncbi Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases
    Orly Weinreb
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology, Rappaport Family Research Institute, Technion Faculty of Medicine, 31096 Haifa, Israel
    J Nutr Biochem 15:506-16. 2004
    b>Tea consumption is varying its status from a mere ancient beverage and a lifestyle habit, to a nutrient endowed with possible prospective neurobiological-pharmacological actions beneficial to human health...
  33. ncbi Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate
    Naghma Khan
    Department of Dermatology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Cancer Res 66:2500-5. 2006
    ..Emerging data amassed from various laboratories around the world suggests that green tea, particularly its major polyphenolic constituent (-)-epigallocatechin-3-gallate (EGCG), possesses remarkable cancer ..
  34. ncbi Green tea catechins, caffeine and body-weight regulation
    M S Westerterp-Plantenga
    Department of Human Biology, NUTRIM, Faculty of Health, Medicine, and Life Sciences, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Physiol Behav 100:42-6. 2010
    ..Tools for obesity management including caffeine, and green tea have been proposed as strategies for weight loss and weight maintenance...
  35. ncbi Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans
    A G Dulloo
    Department of Physiology, Faculty of Medicine, University of Geneva
    Am J Clin Nutr 70:1040-5. 1999
    ..Current interest in the role of functional foods in weight control has focused on plant ingredients capable of interfering with the sympathoadrenal system...
  36. ncbi Green tea and its polyphenolic catechins: medicinal uses in cancer and noncancer applications
    Nurulain T Zaveri
    Drug Discovery Program, Biosciences Division, SRI International, Menlo Park, CA 94025, USA
    Life Sci 78:2073-80. 2006
    Can drinking several cups of green tea a day keep the doctor away? This certainly seems so, given the popularity of this practice in East Asian culture and the increased interest in green tea in the Western world...
  37. ncbi Beneficial effects of tea catechins on diet-induced obesity: stimulation of lipid catabolism in the liver
    T Murase
    Biological Science Laboratories, Kao Corporation, Tochigi, Japan
    Int J Obes Relat Metab Disord 26:1459-64. 2002
    ..We investigated the effects of long-term feeding with tea catechins, which are naturally occurring polyphenolic compounds widely consumed in Asian countries, on the ..
  38. ncbi Green tea consumption and cognitive function: a cross-sectional study from the Tsurugaya Project 1
    Shinichi Kuriyama
    Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Am J Clin Nutr 83:355-61. 2006
    Although considerable experimental and animal evidence shows that green tea may possess potent activities of neuroprotection, neurorescue, and amyloid precursor protein processing that may lead to cognitive enhancement, no human data are ..
  39. ncbi Cognitive function and tea consumption in community dwelling older Chinese in Singapore
    L Feng
    Gerontological Research Programme, National University of Singapore, Department of Psychological Medicine, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074
    J Nutr Health Aging 14:433-8. 2010
    We aimed to examine the relationship between tea consumption and cognitive function in older adults.
  40. ncbi Glutathione-S-transferases M1 (GSTM1) and GSTT1 genotype, smoking, consumption of alcohol and tea and risk of esophageal and stomach cancers: a case-control study of a high-incidence area in Jiangsu Province, China
    Chang Ming Gao
    Division of Epidemiology, Jiangsu Province Institute of Cancer Research, 42 Baiziting, Nanjing 210009, China
    Cancer Lett 188:95-102. 2002
    ..A combined effect was also observed between smoking and the GSTM1 null genotype with regard to esophageal risk. Tea drinking was a protective factor for both cancers, its effect being independent of the GSTT1 and GSTM1 genotypes...
  41. ncbi Tea polyphenols regulate nicotinamide adenine dinucleotide phosphate oxidase subunit expression and ameliorate angiotensin II-induced hyperpermeability in endothelial cells
    Chen Jiang Ying
    School of Human Environmental Science, Mukogawa Women s University, Nishinomiya, Japan
    Hypertens Res 26:823-8. 2003
    ..We observed that tea polyphenols decreased the production of ROS via regulation of the protein expression of nicotinamide adenine ..
  42. ncbi Effects of green tea and EGCG on cardiovascular and metabolic health
    Swen Wolfram
    DSM Nutritional Products Ltd, Department of Human Nutrition and Health, P O Box 3255, Bldg 241 425, CH 4002 Basel, Switzerland
    J Am Coll Nutr 26:373S-388S. 2007
    Since ancient times green tea has been considered a health-promoting beverage...
  43. ncbi Prooxidative effects of green tea polyphenol (-)-epigallocatechin-3-gallate on the HIT-T15 pancreatic beta cell line
    Kwang Sik Suh
    Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, 1 Hoegi dong, Dongdaemun Gu, Seoul 130 701, South Korea
    Cell Biol Toxicol 26:189-99. 2010
    Epigallocatechin-3-gallate (EGCG) is the main polyphenolic constituent in green tea and is believed to function as an antioxidant...
  44. ncbi Regular daily intake of black tea improves oxidative stress biomarkers and decreases serum C-reactive protein levels in type 2 diabetic patients
    Tirang R Neyestani
    National Nutrition and Food Technology Research Institute, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
    Ann Nutr Metab 57:40-9. 2010
    This study was undertaken to evaluate the possible effects of different daily doses of black tea intake on certain oxidative stress, inflammatory and metabolic biomarkers in patients with type 2 diabetes mellitus (T2DM).
  45. ncbi Green tea is neuroprotective in diabetic retinopathy
    Kamila C Silva
    Renal Pathophysiology Laboratory, Investigation on Diabetes Complications, Faculty of Medical Sciences, State University of Campinas, Campinas, Sao Paulo, Brazil
    Invest Ophthalmol Vis Sci 54:1325-36. 2013
    Green tea (GT), widely studied for its beneficial properties in protecting against brain ischemia, is a rich source of polyphenols, particularly (-)-epigallocatechin gallate (EGCG)...
  46. ncbi Green tea extract reduces blood pressure, inflammatory biomarkers, and oxidative stress and improves parameters associated with insulin resistance in obese, hypertensive patients
    Pawel Bogdanski
    Department of Internal Medicine, Metabolic Disorders and Hypertension, Poznan University of Medical Sciences, Poznan, Poland
    Nutr Res 32:421-7. 2012
    Green tea (GT) consumption is known to be associated with enhanced cardiovascular and metabolic health...
  47. ncbi An improved protocol for the isolation of RNA from roots of tea (Camellia sinensis (L.) O. Kuntze)
    Richard Chalo Muoki
    Biotechnology Division, Council of Scientific and Industrial Research Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh 176061, India
    Mol Biotechnol 52:82-8. 2012
    b>Tea, a beverage crop, is a rich source of polyphenols and polysaccharides which greatly attribute to its importance...
  48. ncbi The green tea polyphenol, epigallocatechin-3-gallate, inhibits hepatitis C virus entry
    Sandra Ciesek
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Hepatology 54:1947-55. 2011
    ..Green tea catechins, such as EGCG and its derivatives, epigallocatechin (EGC), epicatechin gallate (ECG), and epicatechin (EC)..
  49. pmc Green tea polyphenols precondition against cell death induced by oxygen-glucose deprivation via stimulation of laminin receptor, generation of reactive oxygen species, and activation of protein kinase Cε
    Usha Gundimeda
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 287:34694-708. 2012
    ..deprivation and reoxygenation (OGD/R) model in PC12 cells, we show that 2-day pretreatment with green tea polyphenols (GTPP) and their active ingredient, epigallocatechin-3-gallate (EGCG), protects cells from subsequent ..
  50. ncbi Green tea intake lowers fasting serum total and LDL cholesterol in adults: a meta-analysis of 14 randomized controlled trials
    Xin Xin Zheng
    Key Laboratory for Clinical Cardiovascular Genetics and Sino German Laboratory for Molecular Medicine, Cardiovascular Institute, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, China
    Am J Clin Nutr 94:601-10. 2011
    The effect of green tea beverage and green tea extract on lipid changes is controversial.
  51. pmc Epigallocatechin Gallate (EGCG) is the most effective cancer chemopreventive polyphenol in green tea
    Guang Jian Du
    Tang Center for Herbal Medicine Research, University of Chicago, Chicago, IL 60637, USA
    Nutrients 4:1679-91. 2012
    Green tea is a popular drink consumed daily by millions of people around the world. Previous studies have shown that some polyphenol compounds from green tea possess anticancer activities. However, systemic evaluation was limited...
  52. pmc Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice
    Randy Strong
    Geriatric Research, Education and Clinical Center and Research Service, South Texas Veterans Health Care System, TX, USA
    J Gerontol A Biol Sci Med Sci 68:6-16. 2013
    ..the results of lifelong treatment of mice, beginning at 4 months of age, with each of five agents, that is, green tea extract (GTE), curcumin, oxaloacetic acid, medium-chain triglyceride oil, and resveratrol, on the life span of ..
  53. ncbi Black and green tea consumption and the risk of coronary artery disease: a meta-analysis
    Ze Mu Wang
    Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
    Am J Clin Nutr 93:506-15. 2011
    Epidemiologic studies are inconsistent regarding the association between tea consumption and the risk of coronary artery disease (CAD).
  54. ncbi High oolong tea consumption predicts future risk of diabetes among Japanese male workers: a prospective cohort study
    Y Hayashino
    Department of Epidemiology and Healthcare Research, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Diabet Med 28:805-10. 2011
    Acute administration of oolong tea decreases blood glucose levels. We investigated the association between long-term oolong tea intake and subsequent risk of developing diabetes among men of working age.
  55. ncbi Coffee, tea, and fatal oral/pharyngeal cancer in a large prospective US cohort
    Janet S Hildebrand
    Epidemiology Research Program, American Cancer Society, 250 Williams Street NW, Atlanta, GA 30303, USA
    Am J Epidemiol 177:50-8. 2013
    ..The authors examined associations of caffeinated coffee, decaffeinated coffee, and tea intake with fatal oral/pharyngeal cancer in the Cancer Prevention Study II, a prospective US cohort study begun in ..
  56. pmc Green tea drinking and risk of pancreatic cancer: a large-scale, population-based case-control study in urban Shanghai
    Jing Wang
    Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, China
    Cancer Epidemiol 36:e354-8. 2012
    Little is known about the etiology of pancreatic cancer. Epidemiological studies on tea consumption and pancreatic cancer risk have been inconclusive...
  57. pmc Functional characterization of proanthocyanidin pathway enzymes from tea and their application for metabolic engineering
    Yongzhen Pang
    Plant Biology Division, Samuel Roberts Noble Foundation, Ardmore, OK 73401, USA
    Plant Physiol 161:1103-16. 2013
    b>Tea (Camellia sinensis) is rich in specialized metabolites, especially polyphenolic proanthocyanidins (PAs) and their precursors...
  58. pmc Anticancer and anti-inflammatory effects of cysteine metabolites of the green tea polyphenol, (-)-epigallocatechin-3-gallate
    Joshua D Lambert
    Department of Food Science, The Pennsylvania State University, 332 Food Science Building, University Park, Pennsylvania 16802, USA
    J Agric Food Chem 58:10016-9. 2010
    ..These results remain to be confirmed in vivo...
  59. ncbi Green tea reduces body fat accretion caused by high-fat diet in rats through beta-adrenoceptor activation of thermogenesis in brown adipose tissue
    J J Choo
    Department of Foods and Nutrition, Kunsan National University, Kunsan, Cheollabuk do 573 701, South Korea
    J Nutr Biochem 14:671-6. 2003
    The aim of the present study was to investigate body fat-suppressive effects of green tea in rats fed on a high-fat diet and to determine whether the effect is associated with beta-adrenoceptor activation of thermogenesis in brown ..
  60. ncbi Magic at the marketplace: Choice blindness for the taste of jam and the smell of tea
    Lars Hall
    Lund University Cognitive Science, Lund University, Sweden
    Cognition 117:54-61. 2010
    ..a tasting venue at a local supermarket and invited passerby shoppers to sample two different varieties of jam and tea, and to decide which alternative in each pair they preferred the most...
  61. pmc The major green tea polyphenol, (-)-epigallocatechin-3-gallate, inhibits obesity, metabolic syndrome, and fatty liver disease in high-fat-fed mice
    Mousumi Bose
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    J Nutr 138:1677-83. 2008
    In this study, we investigated the effects of the major green tea polyphenol, (-)-epigallocatechin-3-gallate (EGCG), on high-fat-induced obesity, symptoms of the metabolic syndrome, and fatty liver in mice...
  62. ncbi Green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat diet
    Nora Chen
    Department of Optometry and Vision Sciences, University of Melbourne, Australia
    Nutr Res 29:784-93. 2009
    The mechanisms of how tea and epigallocatechin-3-gallate (EGCG) lower body fat are not completely understood...
  63. ncbi In vitro cytotoxicity of epigallocatechin gallate and tea extracts to cancerous and normal cells from the human oral cavity
    Jeffrey H Weisburg
    Stern College for Women, Yeshiva University, Department of Biology, 245 Lexington Avenue, New York, NY 10016, U S A
    Basic Clin Pharmacol Toxicol 95:191-200. 2004
    This study compared the in vitro responses of malignant and normal cells from the human oral cavity to tea extracts and to its main polyphenolic component, (-)-epigallocatechin gallate (EGCG)...
  64. ncbi Improvement of periodontal status by green tea catechin using a local delivery system: a clinical pilot study
    Masatomo Hirasawa
    Department of Microbiology, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba Japan
    J Periodontal Res 37:433-8. 2002
    The purpose of this study was to determine the usefulness of green tea catechin for the improvement of periodontal disease...
  65. ncbi A green tea extract high in catechins reduces body fat and cardiovascular risks in humans
    Tomonori Nagao
    Health Care Food Research Laboratories, Kao Corporation, 2 1 3, Bunka, Sumida ku, Tokyo, 131 8501, Japan
    Obesity (Silver Spring) 15:1473-83. 2007
    The body fat reducing effect and reduction of risks for cardiovascular disease by a green tea extract (GTE) high in catechins was investigated in humans with typical lifestyles.
  66. ncbi Effect of cocoa and tea intake on blood pressure: a meta-analysis
    Dirk Taubert
    Department of Pharmacology, University Hospital of Cologne, Gleueler Strasse 24, D 50931 Cologne, Germany
    Arch Intern Med 167:626-34. 2007
    Epidemiological evidence suggests blood pressure-lowering effects of cocoa and tea. We undertook a meta-analysis of randomized controlled trials to determine changes in systolic and diastolic blood pressure due to the intake of cocoa ..
  67. ncbi Green tea consumption and prostate cancer risk in Japanese men: a prospective study
    Norie Kurahashi
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Am J Epidemiol 167:71-7. 2008
    ..such as dietary habits may play a major role in the causation of prostate cancer and the high consumption of green tea in Asian populations, this low incidence may be partly due to the effects of green tea...
  68. ncbi EGCG, a green tea polyphenol, improves endothelial function and insulin sensitivity, reduces blood pressure, and protects against myocardial I/R injury in SHR
    Maria A Potenza
    Departments of Pharmacology and Human Physiology, Medical School, University of Bari, 70124 Bari, Italy
    Am J Physiol Endocrinol Metab 292:E1378-87. 2007
    Epigallocatechin gallate (EGCG), a bioactive polyphenol in green tea, may augment metabolic and vascular actions of insulin...
  69. ncbi Tea polyphenols: prevention of cancer and optimizing health
    H Mukhtar
    Department of Dermatology, Case Western Reserve University, Cleveland, OH 44106, USA
    Am J Clin Nutr 71:1698S-702S; discussion 1703S-4S. 2000
    The tea plant Camellia sinesis is cultivated in >30 countries...
  70. ncbi Human gamma delta T cells recognize alkylamines derived from microbes, edible plants, and tea: implications for innate immunity
    J F Bukowski
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 11:57-65. 1999
    ....
  71. pmc Multitargeted therapy of cancer by green tea polyphenols
    Naghma Khan
    Department of Dermatology, University of Wisconsin Madison, Medical Sciences Center, B 25, 1300 University Avenue, Madison, WI 53706, USA
    Cancer Lett 269:269-80. 2008
    b>Tea ranks second only to water as a major component of fluid intake worldwide and has been considered a health-promoting beverage since ancient times...
  72. ncbi The green tea polyphenol (-)-epigallocatechin-3-gallate blocks nuclear factor-kappa B activation by inhibiting I kappa B kinase activity in the intestinal epithelial cell line IEC-6
    F Yang
    Graduate Program in Nutritional Sciences, University of Kentucky and Veterans Administration Medical Center, Lexington, Kentucky, USA
    Mol Pharmacol 60:528-33. 2001
    ..We previously showed that green tea polyphenols inhibited endotoxin-mediated tumor necrosis factor-alpha (TNF alpha) production by blocking NF-kappa B ..
  73. ncbi Effect of tea phenolics and their aromatic fecal bacterial metabolites on intestinal microbiota
    Hui Cheng Lee
    Department of Microbiology, National University of Singapore, 5 Science Drive 2, Singapore 117597, Republic of Singapore
    Res Microbiol 157:876-84. 2006
    b>Tea is rich in polyphenols and other phenolics that have been widely reported to have beneficial health effects...
  74. ncbi Anti-obesity effects of green tea: from bedside to bench
    Swen Wolfram
    DSM Nutritional Products, Department of Human Nutrition and Health, Basel, Switzerland
    Mol Nutr Food Res 50:176-87. 2006
    During the last decade, the traditional notion that green tea consumption benefits health has received significant scientific attention and, particularly, the areas of cardiovascular disease and cancer were subject to numerous studies...
  75. ncbi Role of hydrogen peroxide in bactericidal action of catechin
    Hidetoshi Arakawa
    School of Pharmaceutical Sciences, Department of Analytical Chemistry, Showa University, Tokyo, Japan
    Biol Pharm Bull 27:277-81. 2004
    ..EC), epicatechin gallate (ECg), epigallocatechin (EGC) and epigallocatechin gallate (EGCg)), which occur in green tea and black tea, possess strong bactericidal action...
  76. pmc Phase II randomized, placebo-controlled trial of green tea extract in patients with high-risk oral premalignant lesions
    Anne S Tsao
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Prev Res (Phila) 2:931-41. 2009
    Epidemiologic and preclinical data support the oral cancer prevention potential of green tea extract (GTE)...
  77. ncbi Molecular targets of tea polyphenols in the cardiovascular system
    Verena Stangl
    Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie Charité Universitätsmedizin Berlin, CCM, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Cardiovasc Res 73:348-58. 2007
    b>Tea-derived polyphenols have attracted considerable attention in the prevention of cancer and cardiovascular diseases...
  78. ncbi Epigallocatechin gallate from green tea (Camellia sinensis) increases lifespan and stress resistance in Caenorhabditis elegans
    Sami Abbas
    Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany
    Planta Med 75:216-21. 2009
    Epigallocatechin gallate (EGCG) is a major green tea polyphenol with pronounced antioxidative activity. The effects of EGCG on lifespan and stress resistance in wild-type N2 and transgenic strains of Caenorhabditis elegans [ HSP-16...
  79. ncbi Green and black tea consumption and risk of stroke: a meta-analysis
    Lenore Arab
    David Geffen School of Medicine, Los Angeles, CA 90095 1736, USA
    Stroke 40:1786-92. 2009
    Experimental models of stroke provide consistent evidence of smaller stroke volumes in animals ingesting tea components or tea extracts...
  80. ncbi Ester bond-containing tea polyphenols potently inhibit proteasome activity in vitro and in vivo
    S Nam
    Drug Discovery Program, H. Lee Moffitt Cancer Center and Research Institute and Interdisciplinary Oncology Program and Department of Biochemistry and Molecular Biology, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    J Biol Chem 276:13322-30. 2001
    It has been discovered that proteasome inhibitors are able to induce tumor growth arrest or cell death and that tea consumption is correlated with cancer prevention...
  81. ncbi Potential role of green tea catechins in various disease therapies: progress and promise
    Judith C W Mak
    Departments of Medicine and Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong, China
    Clin Exp Pharmacol Physiol 39:265-73. 2012
    Green tea (from the plant Camellia sinensis), a beverage whose consumption started 5000 years ago in China, has important biological and pharmacological properties...
  82. pmc Green tea as inhibitor of the intestinal absorption of lipids: potential mechanism for its lipid-lowering effect
    Sung I Koo
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269 4017, USA
    J Nutr Biochem 18:179-83. 2007
    Animal and epidemiological studies suggest that green tea catechins may reduce the risk of cardiovascular diseases [e.g., coronary heart disease (CHD)]...
  83. pmc Tea drinking habits and oesophageal cancer in a high risk area in northern Iran: population based case-control study
    Farhad Islami
    Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences, 14117 Tehran, Iran
    BMJ 338:b929. 2009
    To investigate the association between tea drinking habits in Golestan province, northern Iran, and risk of oesophageal squamous cell carcinoma.
  84. pmc Green tea polyphenol EGCG blunts androgen receptor function in prostate cancer
    Imtiaz A Siddiqui
    Department of Dermatology, University of Wisconsin, Madison, Wisconsin 53706, USA
    FASEB J 25:1198-207. 2011
    ..Here, we provide evidence that epigallocatechin-3-gallate (EGCG), the major polyphenol in green tea, is a direct antagonist of androgen action...
  85. pmc Changing patterns of clinical malaria since 1965 among a tea estate population located in the Kenyan highlands
    G D Shanks
    US Army Medical Research Unit Kenya
    Trans R Soc Trop Med Hyg 94:253-5. 2000
    The changing epidemiology of clinical malaria since 1965 among hospitalized patients was studied at a group of tea estates in the western highlands of Kenya...
  86. ncbi Effects of catechin enriched green tea on body composition
    Hongqiang Wang
    Unilever R and D, Shanghai, China
    Obesity (Silver Spring) 18:773-9. 2010
    ..However, an increasing amount of mechanistic and clinical evidence is building for green tea (GT)...
  87. ncbi Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG
    Hye Kyung Na
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak Ku, Seoul 151 742, South Korea
    Food Chem Toxicol 46:1271-8. 2008
    Frequent consumption of green tea, one of the most popular and widely consumed beverages, has been known to protect against development of various cancers according to numerous experimental and several population-based studies...
  88. ncbi Cancer prevention by tea: Evidence from laboratory studies
    Chung S Yang
    Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Pharmacol Res 64:113-22. 2011
    The cancer preventive activities of tea (Camellia sinensis Theaceae) have been studied extensively...
  89. ncbi Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration
    Y Levites
    Eve Topf, Technion-Faculty of Medicine, Haifa, Israel
    J Neurochem 78:1073-82. 2001
    In the present study we demonstrate neuroprotective property of green tea extract and (-)-epigallocatechin-3-gallate in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice model of Parkinson's disease...
  90. ncbi Antiobesity effects of green tea catechins: a mechanistic review
    Tia M Rains
    Provident Clinical Research, Glen Ellyn, IL 60137, USA
    J Nutr Biochem 22:1-7. 2011
    Green tea catechins (GTC) are polyphenolic compounds present in the unfermented dried leaves of the plant, Camellia sinensis...
  91. ncbi Green tea extract decreases oxidative stress and improves insulin sensitivity in an animal model of insulin resistance, the fructose-fed rat
    Isabelle Hininger-Favier
    INSERM, U884, Grenoble, F 38000, France
    J Am Coll Nutr 28:355-61. 2009
    b>Tea polyphenols, as both insulin potentiating factors and antioxidants, are postulated to act in preventing the metabolic syndrome, which is characterized by insulin resistance, dyslipidemia, and increased oxidative stress.
  92. pmc Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols
    S Gupta
    Department of Dermatology, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 98:10350-5. 2001
    ..Employing male TRAMP mice, we show that oral infusion of a polyphenolic fraction isolated from green tea (GTP) at a human achievable dose (equivalent to six cups of green tea per day) significantly inhibits CaP ..
  93. ncbi Tea flavonoids and cardiovascular health
    Jonathan M Hodgson
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
    Mol Aspects Med 31:495-502. 2010
    The two main types of tea are green and black. Both green and black teas are rich dietary sources of flavonoids. Available evidence suggests that regular tea consumption may reduce the risk of cardiovascular disease...
  94. ncbi Relationship between intake of green tea and periodontal disease
    Mitoshi Kushiyama
    Department of Preventive Dentistry, Kyushu University Faculty of Dental Science, Fukuoka, Japan
    J Periodontol 80:372-7. 2009
    Green tea is a very popular beverage, and in vitro studies have shown that green tea polyphenols inhibit the growth and cellular adherence of periodontal pathogens and their production of virulence factors...
  95. ncbi Green tea polyphenols attenuate deterioration of bone microarchitecture in female rats with systemic chronic inflammation
    C L Shen
    Department of Pathology, Texas Tech University Health Sciences Center, BB 198, 3601 4th Street, Lubbock, TX 79430 9097, USA
    Osteoporos Int 22:327-37. 2011
    Green tea polyphenols (GTP) are promising agents for preventing bone loss. GTP supplementation sustained microarchitecture and improved bone quality via a decrease in inflammation...
  96. ncbi Green tea extract suppresses NFκB activation and inflammatory responses in diet-induced obese rats with nonalcoholic steatohepatitis
    Hea Jin Park
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT, USA
    J Nutr 142:57-63. 2012
    ..The objective of this study was to determine whether the antioxidant and antiinflammatory activities of green tea extract (GTE) would protect against NASH in a model of diet-induced obesity...
  97. ncbi Green tea prevents hyperglycemia-induced retinal oxidative stress and inflammation in streptozotocin-induced diabetic rats
    Binit Kumar
    Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences and Research, University of Delhi, New Delhi, India
    Ophthalmic Res 47:103-8. 2012
    Our objective was to investigate the effect of green tea (GT) on diabetes-induced retinal oxidative stress and proinflammatory parameters in rats.
  98. ncbi Effects of green tea on gene expression of hepatic gluconeogenic enzymes in vivo
    Yu Koyama
    Laboratory of Cellular Biochemistry, COE Program in the 21st Century, Graduate School of Nutritional and Environmental Sciences, The University of Shizuoka, Shizuoka, Japan
    Planta Med 70:1100-2. 2004
    It has recently been reported that the major green tea polyphenolic constituent, epigallocatechin 3-gallate (EGCG), mimics the cellular effects of insulin including the reductive effect on the gene expression of rate-limiting ..
  99. ncbi Epigallocatechin gallate, the main component of tea polyphenol, binds to CD4 and interferes with gp120 binding
    Kazushige Kawai
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Japan
    J Allergy Clin Immunol 112:951-7. 2003
    Epigallocatechin gallate (EGCG), the major component of tea polyphenol, has been reported to have various physiologic modulatory activities...
  100. ncbi Growth inhibitory and antimetastatic effect of green tea polyphenols on metastasis-specific mouse mammary carcinoma 4T1 cells in vitro and in vivo systems
    Manjeshwar S Baliga
    Department of Dermatology, University of Alabama at Birmingham, 1670 University Boulevard, Birmingham, AL 35294, USA
    Clin Cancer Res 11:1918-27. 2005
    ..Dietary habits may have a role in breast cancer risk and prevention as well. Here, we examined the effect of green tea polyphenols (GTP) on growth and metastasis of highly metastatic mouse mammary carcinoma 4T1 cells in vitro and in ..
  101. ncbi Protective effects of green tea polyphenols in the 6-OHDA rat model of Parkinson's disease through inhibition of ROS-NO pathway
    Shuhong Guo
    State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Academia Sinica, Beijing, China
    Biol Psychiatry 62:1353-62. 2007
    ..Our in vitro experiments suggested that green tea polyphenols (GTP) might protect dopamine neurons through inhibition of NO and reactive oxygen species (ROS).

Research Grants80

  1. Analyzer for Monitoring Personal Environmental Exposure to Fluids and Materials
    MATTHEW CUSACK; Fiscal Year: 2010
    ..comes into contact, including: food stuffs, medicines, spices, condiments, liquids (water, wine, coffee beer, tea) and all materials placed on the subject/patient's skin such as: lotions, perfumes, cosmetics (lipstick, ..
  2. Roles of NF-kB/Rel in the pathogenesis of breast cancer
    Gail E Sonenshein; Fiscal Year: 2012
    ..Cancer epidemiological studies have shown an inverse association between green tea consumption and breast cancer incidence...
  3. Green Tea and Reduction of Breast Cancer Risk
    MINDY SUSAN KURZER; Fiscal Year: 2013
    ..by applicant): The ultimate goal of this proposal is to gain a full understanding of the mechanisms by which tea catechins inhibit breast carcinogenesis in humans...
  4. Combined use of green tea and quercetin in prostate cancer
    SUSANNE MARGARETE HENNING; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The anticarcinogenic activity of green tea has been demonstrated in many epidemiological, animal and cell culture studies...
  5. Green tea effects on gene expression in tobacco users
    Joel L Schwartz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Green tea (GT) is a mixture largely of catechins, which are phenol flavonoids, and caffeine, that has shown efficacy in preventing lung cancer and a large host of other spontaneous and experimentally ..
  6. Inhibition of CCR1/CCR5 mediated angiogenesis and joint destruction by EGCG
    Salah Uddin Ahmed; Fiscal Year: 2010
    ..to test the efficacy of epigallocatechin-3-gallate (EGCG), a potential anti-inflammatory molecule found in green tea, in inhibiting the destruction of the cartilage and bone in RA...
  7. Regulation of IL-6 mediated inflammation and tissue destruction by EGCG
    Salah Uddin Ahmed; Fiscal Year: 2013
    ..Epigallotcatechin-3-gallate (EGCG), a potent anti-inflammatory polyphenol found in green tea, blocks IL-1[unreadable]-induced IL-6 synthesis in human RA synovial fibroblasts (RA-FLS)...
  8. Phase I Study to Evaluate Safety and Toxicity of EGCG in HIV-1-Infected Subjects
    Christina L Nance; Fiscal Year: 2011
    ..One such CAM candidate is the green tea catechin, epigallocatechin gallate (EGCG)...
  9. Quercetin to enhance the bioavailability and activity of green tea polyphenols
    SUSANNE MARGARETE HENNING; Fiscal Year: 2013
    ..the proposed human intervention study remains to determine whether a combined administration of quercetin and green tea (GT) will increase the bioavailability and decrease the metabolism of GT polyphenols (GTPs) such as ..
  10. Modifiable lifestyle-related factors and triple negative breast cancer prognosis
    SARAH JEAN NECHUTA; Fiscal Year: 2013
    ..e., soy food intake, vegetable intake, alcohol consumption, and tea consumption) with recurrence, breast cancer-specific mortality, and total mortality among women (1) with TNBC and (..
  11. Green Tea Nanocarriers: A Promising Approach for the Prevention and Treatment of
    Shu Wang; Fiscal Year: 2011
    ..This is particularly true for (-)- epigallocatechin gallate (EGCG), a natural compound found in green tea, that is valuable for the prevention and treatment of atherosclerosis...
  12. Homogenous HTS Assays to Screen for Inhibitors of Keap1-Nrf2 Interaction
    Longqin Hu; Fiscal Year: 2010
    ..sulforaphane, curcumin, and epigallocatechin gallate derived from natural sources such as fruits, vegetables, and tea products...
  13. Field Validation of New XRF Analyzers: Assessing Personal Exposure to Metals
    PATRICK JEREMY PARSONS; Fiscal Year: 2012
    ..g., home or workplace). This includes samples of liquids we consume (water, juice, tea, wine, salad dressings, and other condiments, etc...
  14. Mechanisms of Novel Herbal Therapies for Sepsis.
    Haichao Wang; Fiscal Year: 2013
    ..of several commonly used Chinese herbs, Danshen (Salvia miltiorrhiza, steroid-like tanshinones) and Green tea (Camellia sinensis, epigallocatechin gallate, EGCG) effectively attenuated endotoxin-induced HMGB1 release, and ..
  15. Aromatic Amine-DNA Lesions: Mutagenicity and Repair
    Suse Broyde; Fiscal Year: 2013
    ..foods, notably meats, products of fuel combustion such as diesel exhaust, tobacco smoke, cooking oil fumes, coffee, tea and spices, and polluted air and water...
  16. Regulation of Intestinal Bile Acid Transport
    Waddah A Alrefai; Fiscal Year: 2013
    ..Also beneficial dietary components such as green tea catechin, (-)-epigallocatechin-3-gallate, EGCG, inhibits ASBT function in a lipid-raft dependent manner...
  17. CHEMOPREVENTION WITH GREEN TEA POLYPHENON E (PPE) AND EGFR-TKIs IN HEAD AND NECK
    DONG MOON SHIN; Fiscal Year: 2011
    ..In this study, we propose to use a combination of green tea polyphenon E (PPE) and erlotinib (Tarceva or OSI-774), a tyrosine kinase inhibitor (TKI) of the epidermal growth ..
  18. Anti-carcinogenic effects of White Tea on Lung Cancer
    Jenny T Mao; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The ultimate goal of this R21 project is to evaluate the potential of white tea extract (WTE) for lung cancer chemoprevention...
  19. Chemoprevention of Pancreatic Cancer by EGCG
    Rakesh K Srivastava; Fiscal Year: 2012
    ..Therefore, new options for prevention and treatment are needed. This proposal is based on the use of green tea polyphenol, epigallocatechin-3-gallate (EGCG), which exerts significant inhibitory effects on diverse cellular ..
  20. MONOAMINE AND HALLUCINOGEN EFFECTS ON RODENT BEHAVIOR
    Mark A Geyer; Fiscal Year: 2013
    ..ritual, or religious contexts, including psilocybin mushrooms (psilocin), peyote cactus (mescaline), and Ayahuasca tea (DMT, 5MeODMT)...
  21. Mechanistic Studies on Lung Cancer Prevention by Tea Polyphenols
    Chung S Yang; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Our long-term goal is to understand the cancer preventive activities of tea constituents and their applications to human cancer prevention...
  22. Tea Modulation of Colon Carcinogenesis
    Michael Wargovich; Fiscal Year: 2013
    ..Polyphenols from green tea have widespread cancer chemopreventive activity...
  23. Herb-Drug Glucuronidation Interactions
    Reginald F Frye; Fiscal Year: 2011
    ..effect of prolonged Ginkgo biloba administration on mycophenolic acid pharmacokinetics;and 2) the effect of green tea leaf extract administration on raloxifene pharmacokinetics...
  24. Improving the performance of elbow reconstruction
    Timothy M Wright; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Total elbow arthroplasty (TEA) is not as predictable or durable as joint arthroplasties for the knee and hip...
  25. Inhibition of Lung Carcinogenesis by Tea Polyphenols and Atorvastatin
    Chung S Yang; Fiscal Year: 2012
    ..provided by applicant): The objective of this project is to study the inhibition of lung carcinogenesis by green tea polyphenols and the synergistic action when used in combination with atorvastatin (ATST, trade name Lipitor)...
  26. Longitudinal Analysis of Transcriptomic Endophenotypes in Asthma
    Geoffrey L Chupp; Fiscal Year: 2013
    ..in the sputum and circulation of asthmatics and has identified 3 transcriptional endophenotypes of asthma (sputum TEA clusters)...
  27. TEAD4 and Trophoblast Lineage
    Soumen Paul; Fiscal Year: 2013
    ..Gene knockout studies in mice showed that TEAD4, a member of TEA-domain containing transcription factors, is the master orchestrator of the TE-specific transcriptional program...
  28. Safety and Efficacy of Single-use Cliradex Pads for Ocular Mites
    Scheffer C G Tseng; Fiscal Year: 2012
    ..However, we have discovered that tea tree oil (TTO), a natural essential oil steam-distilled from the leaf of Melaleuca alternifolia, is effective in ..
  29. Morgan State University-Public Health Program-CAM Research Training Program (Inst
    YVONNE LAFAYETTE BRONNER; Fiscal Year: 2010
    ..To date MSU-PHP CAM Fellows have investigated the relationship of Yoga to hypertension, black tea and lipid excretion, concordance of practitioner/patient beliefs on CAM treatment outcomes, herbals and memory in ..
  30. Prevention of Metastatic Cancer Using a Novel Vitamin E Analog
    Emmanuel T Akporiaye; Fiscal Year: 2010
    ..One drug that may have these properties is alpha-Tocopheryloxyacetic acid (a-TEA)...
  31. CAM Herbal Cocktails for Boosting Antioxident Activity to Treat Liver Disease
    Roy L Hawke; Fiscal Year: 2010
    ..a pharmacokinetic study that will determine the effects of a CAM herbal cocktail containing milk thistle and green tea extracts on the exposures of patients to major silymarin flavonolignans...
  32. Signaling Pathways in Stages of Tumorigenesis
    Gail E Sonenshein; Fiscal Year: 2012
    ..will focus on elucidating the roles of c-Rel, RelB, and IKKe/i kinase, and tumor inhibitory effects of green tea polyphenols...
  33. Regulation of RNA polymerase III transcription by EGCG
    Laura M Schramm; Fiscal Year: 2013
    ..TFIIIB is a target for repression by tumor suppressors and activation by oncogenes. The green tea component EGCG has been demonstrated to inhibit the growth of a variety of cancer cells in vivo and in vitro...
  34. The role of a novel tau-associated protein in neurodegeneration
    Irving E Vega; Fiscal Year: 2012
    ..Herein, we refer to this novel protein as Tau-EF hand containing Associated protein (TEA)...
  35. Neural Models of Behavior
    Dana H Ballard; Fiscal Year: 2011
    ..Our studies and those of others have demonstrated that other complex behaviors such as tea making and sandwich making can be readily seen as consisting as compositions of more elemental behaviors...
  36. Anticarcinogenic Mechanisms of Tea Constituents
    Zigang Dong; Fiscal Year: 2012
    ..competitive renewal application to investigate the molecular mechanisms of the chemopreventive effect of cancer by tea polyphenols...
  37. SAFETY AND NEUROPROTECTIVE EFFECTS OF POLYPHENON E IN MULTIPLE SCLEROSIS
    Jesus Lovera; Fiscal Year: 2012
    ..a potent antioxidant and is the main component contained in polyphenon E, an extract from the leaves of the green tea plant (Camellia sinensis)...
  38. Fatty Liver Preventive Effects and High Dose Hepatotoxicity of Tea Polyphenols
    Joshua D Lambert; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The beneficial health effects of tea (Camellia sinensis) and its major polyphenolic constituent, (-)- epigallocatechin-3-gallate (EGCG), have been extensively studied and publicized...
  39. Polyphenon E for the Chemoprevention of Colorectal Cancer
    Frank A Sinicrope; Fiscal Year: 2013
    ABSTRACT Green tea constituents including polyphenols have been convincingly shown to confer cancer preventive properties in animal model systems...
  40. Transcutaneous electroacupuncture for gastroparesis
    Jiande Chen; Fiscal Year: 2010
    ..Recent studies in our lab with EA or transcutaneous EA (TEA) have suggested a therapeutic role of EA or TEA for gastric motility disorders...
  41. Neuroprotective effect of flavanol (-) epicatechin after intracerebral hemorrhage
    Jian Wang; Fiscal Year: 2013
    ..Cocoa and green tea are rich in flavanols, including (-)-epicatechin...
  42. Oral administration of TeaMemTM inhibits Alzheimer's disease pathogenesis
    Jun Tan; Fiscal Year: 2009
    ..Our recent data show that green tea derived (-)-epigallocatechin-3-gallate (EGCG) reduces A? peptide generation in "Swedish" mutant APP-overexpressing ..
  43. Targeting prostate cancer stem cells to delay prostate cancer progression
    Jin Rong Zhou; Fiscal Year: 2012
    ..stem cell self-renewal marker, the transcription factor B lymphoma Mo-MLV insertion region 1 (Bmi-1), that black tea significantly delayed androgen ablation-induced progression of prostate tumors associated with downregulation of ..
  44. Cancer Risk Reduction and Diet: A Cohort Study of Women
    Wei Zheng; Fiscal Year: 2013
    ..cancer risk with a specific focus on evaluating dietary protective factors, such as regular consumption of soyfood, tea, and ginseng...
  45. Characterization of EGCG-receptors: Role in mediating the effects of green tea
    MARK LUNDQUIST; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): (-)-Epigallocatechin-3-gallate (EGCG) is a component of green tea, a widely used herbal remedy...
  46. EGCG Has Anti-prostate Cancer Activity by Inhibiting hsp90
    Thomas A Gasiewicz; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Numerous studies have indicated the effectiveness of green tea for anti-cancer activity in both humans and experimental animals, and green tea extract has reached clinical trials for examination of ..
  47. Inhibition of Cholesterol Synthesis by Green and Black Tea
    Todd D Porter; Fiscal Year: 2010
    ..a widespread problem for which there is great interest in alternative medicines, the demonstrated ability of black tea to decrease serum cholesterol levels is of particular interest...
  48. SPORE IN BREAST CANCER
    SARA SUKUMAR; Fiscal Year: 2010
    ..Project 5 explores the development of broccoli sprouts tea as a breast cancer prevention agent...
  49. Targeting Early Activated T cells for Adoptive Therapy
    David J Cole; Fiscal Year: 2010
    ..These "early activated" T (TEA) cells are characterized by increased expression of lymph node (LN) homing receptors, robust proliferation in vitro,..
  50. CHEMOPREVENTION OF LUNG SQUAMOUS CELL CARCINOMA WITH POLYPHENON E
    Ming You; Fiscal Year: 2012
    ..2004) and that green tea polyphenols exhibit a significant efficacy against the development of lung squamous cell carcinomas (preliminary ..
  51. Participation in the Eastern Cooperative Oncology Group
    Joseph Aisner; Fiscal Year: 2013
    ..Despite the failure of the green tea study to launch, another study from CINJ proposes to test a unique antibody in paraffin sections to distinguish ..
  52. High-throughput robotic analysis of integrated neuronal phenotypes
    Hongkui Zeng; Fiscal Year: 2013
    ..In a multidisciplinary tea, we propose to augment this robot, coupling it to transcriptional and morphological analysis strategies, yielding a ..
  53. Regulation and biological impact of IL-17 production by gamma delta T cells
    Yueh Hsiu Chien; Fiscal Year: 2010
    ..While it is largely an starts the resolution program and in vertebrates, it has evolved to require a T cell cytokine, launches the adaptive immune .2) (U) =w' pay -,Q" ,tea --6 E'6 0 =-0 0-0 ono
  54. Nicotine Emissions, Toxicity, and Behavior by Electronic Cigarettes
    RISA JEAN ROBINSON; Fiscal Year: 2013
    ..Herein, our multidisciplinary tea proposes to establish comparative nicotine emissions and dosages between e-cigarettes and cigarettes, and to ..
  55. ROLE OF AP-1 IN THE CHEMOPREVENTIVE FUNCTION OF GREEN TEA IN VIVO
    JAY WINTON TICHELAAR; Fiscal Year: 2010
    ..Green tea and its polyphenolic constituent (-)-epigallocatechin gallate (EGCG) are effective agents for chemoprevention of ..
  56. Green tea catechins in precancerorus prevention
    HWA CHAIN WANG; Fiscal Year: 2009
    The goal of this project is to identify effective constituents and mechanisms of green tea catechins (GTCs) in precancerous prevention of human breast cancers associated with long-term exposures to environmental carcinogens...
  57. Soyfood, gene polymorphisms and endometrial cancer risk
    Xiao Ou Shu; Fiscal Year: 2010
    ..produced many significant, novel research findings from this study, particularly those related to soy food intake, tea consumption, genetic polymorphisms in the estrogen pathway, and gene-diet interactions in relation to the risk of ..
  58. SYNTHETIC STUDIES ON TUMOR PROMOTERS AND INHIBITORS
    PAUL ANTHONY WENDER; Fiscal Year: 2013
    ..directed at the synthesis of prostratin and its functional analogs, the former an active constituent in a medicinal tea used by healers in Samoa and now in preclinical development for eradicating HIV/AIDS virus through latent virus ..
  59. Timing and neural bases of complex word recognition: electrophysiological studies
    ROBERT D FIORENTINO; Fiscal Year: 2011
    ..whether complex words like 'teacup'are stored and retrieved in terms of smaller parts called morphemes (tea/cup), or whether all words are treated alike as whole-word chunks...
  60. Reaching with Central Field Loss
    LAURA LYNN WALKER RENNINGER; Fiscal Year: 2013
    ..take place for eye-hand coordination to be effective in daily tasks, such as making a sandwich or pouring a cup of tea. As we develop our understanding of adaptations that benefit (or impair) functional outcome for AMD patients, we ..
  61. TEA for Families and Children: A Randomized Intervention Trial
    Li Li; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This 5-year project is a randomized controlled trial of the TEA (Together for Empowerment Activities) intervention...
  62. Studies to evaluate the tox and carcinogentic potential of test articles
    MILTON D HEJTMANCIK; Fiscal Year: 2011
    ..90-day and 2-year studies of green tea extract;the 90-day study is completed and study reports are due in the winter 2006...
  63. MOLECULAR CHEMOPREVENTION MECHANISMS OF TEA POLYPHENOLS
    Steven Stratton; Fiscal Year: 2005
    ..This project will focus on skin cancer chemoprevention mechanisms with polyphenolic derivatives of tea, Camellia sinensis. Green tea is one of the most widely consumed beverages in the world...
  64. Combined Chemoprevention in Beta-Catenin Mutant Mice
    Gayle Orner; Fiscal Year: 2004
    ..b>Tea prevents intestinal and/or colorectal cancer in a variety of animal models...
  65. Combined effects of tea plus NSAIDS towards colon cancer
    Gayle Orner; Fiscal Year: 2004
    ..b>Tea prevents intestinal and/or colorectal cancer in a variety of animal models and may be a suitable alternative or ..
  66. Tea Tree Oil for Treating Ocular Demodex Infestation
    Scheffer Tseng; Fiscal Year: 2009
    ..Using this assay, we have discovered that the Baby Shampoo does not, but tea tree oil (TTO), an essential oil distilled from Melaleuca alternifolia does, kill mites...
  67. Mechansim of tea catechin's inhibition of angiogenesis
    Mohsen Meydani; Fiscal Year: 2003
    Epidemiological data and experimental studies suggest that catechins of black or green tea with potent antioxidant activity have anticancer properties...
  68. Expression of MRP2 and OCTI Transporters in the Kidney
    JOHN WELBORN; Fiscal Year: 2001
    ..Renal pathways for the secretion of OCs (such as tetraethylammonium, TEA) have also received considerable attention...
  69. Induction Of Apoptosis in Osteosarcoma By Green Tea
    TARIQ HAQQI; Fiscal Year: 2005
    ..b>Tea, a preparation from the dried leaves of Camellia sinensis, is a widely and popularly consumed beverage in the world...
  70. Reactivation of GSTP1 Gene by Green Tea Polyphenols
    Sanjay Gupta; Fiscal Year: 2005
    ..In recent years, green tea has gained considerable interest as a cancer preventive agent and we have recently demonstrated that oral ..
  71. Mechanism of Polyphenolic Inhibition of NADPH Oxidase
    Jonathan Dordick; Fiscal Year: 2006
    ..preparations as well as being found in different fruits and vegetables, olive oil, and beverages like red wine and tea. Based on a growing body of evidence it is thought that the chemoprotective effect of polyphenols involves the ..
  72. Targeting Egr-1 with Curcumin Analogs for Prostate Cancer Prevention
    Marco Bisoffi; Fiscal Year: 2009
    ..While this concept has long been recognized for prominent compounds, such as from green tea (Epigallocatechin-3-gallate), tomatoes (Lycopene), grapes (Resveratrol), and Turmeric (Curcumin), the ..
  73. Effects of Antioxidants on Human Macular Pigments
    Kyung Jin Yeum; Fiscal Year: 2006
    ..MP effectively absorbs blue light as well as quenches reactive oxygen species (ROS). Green tea polyphenols are also effective scavenger of ROS in vitro...
  74. Bioavailability of Tea Polyphenols in Prostate Cancer
    Susanne Henning; Fiscal Year: 2002
    b>Tea has gained considerable attention as a cancer chemopreventive agent because of the growth inhibitory effect in cell cultures, anticarcinogenic effects in animal models and effect on risk reduction of cancer and heart disease in ..
  75. EPIGALLOCATECHIN GALLATE AS A NEUROPROTECTANT IN A MODEL OF MULTIPLE SCLEROSIS
    Gail Marracci; Fiscal Year: 2007
    ..EGCG) is a potent antioxidant of the flavan-3-ol family of polyphenolic compounds and is found enriched in green tea from the plant Camellia sinensis...
  76. Maturation and myogenic reactivity of cerebral arteries
    John Buchholz; Fiscal Year: 2005
    ..In a separate series of experiments, the contractile effect of tetraethylammonium (TEA; a KCa channel blocker) was determined in cerebral arteries from neonatal and adult mice...
  77. FLAVONOID BIOAVAILABILITY IN HUMANS-CELLULAR STUDIES
    Thomas Walle; Fiscal Year: 2005
    ..between SGLT1 and MRP2, including mechanisms involved, in the enterocyte absorption of flavonoid glycosides and the tea flavonoids, two main classes of dietary flavonoids...
  78. CHINESE TEA AND STOMACH CANCER IN SHANGHAI
    Chung cheng Hsieh; Fiscal Year: 1993
    A population-based case-control study is proposed to study the effect of Chinese green tea on risk of stomach cancer...
  79. The effects of caffeine and caffeine withdrawal on mood, cognition, and fMRI.
    MERIDETH ADDICOTT; Fiscal Year: 2009
    Caffeine is a widely used neurostimulant that is found in many foods and beverages such as coffee, tea, soft drinks, and chocolate...
  80. Dietary flavanols and angiotensin converting enzyme
    Cesar Fraga; Fiscal Year: 2007
    ..studies in humans and animals indicate that cocoa and other foods and beverages that are rich in flavanols as tea and wine, can benefit cardiovascular function, inclusive regulating blood pressure...