- Polybrominated diphenyl ethers: occurrence, dietary exposure, and toxicology
P O Darnerud
National Food Administration, Toxicology Division, Uppsala, Sweden
Environ Health Perspect 109:49-68. 2001
..Moreover, the time trend of PBDEs in human breast milk is alarming for the future...
- Bile salt-stimulated lipase from human milk binds DC-SIGN and inhibits human immunodeficiency virus type 1 transfer to CD4+ T cells
Marloes A Naarding
Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
Antimicrob Agents Chemother 50:3367-74. 2006
..We have previously demonstrated that a multimeric LeX component in human milk binds to DC-SIGN, preventing HIV-1 from interacting with this receptor...
- Consumption of human milk oligosaccharides by gut-related microbes
Department of Viticulture and Enology, University of California, Davis, California 95616, USA
J Agric Food Chem 58:5334-40. 2010
b>Human milk contains large amounts of complex oligosaccharides that putatively modulate the intestinal microbiota of breast-fed infants by acting as decoy binding sites for pathogens and as prebiotics for enrichment of beneficial bacteria...
- Correlates of mother-to-child human immunodeficiency virus type 1 (HIV-1) transmission: association with maternal plasma HIV-1 RNA load, genital HIV-1 DNA shedding, and breast infections
G C John
Department of Medicine, University of Washington, Seattle, WA, USA
J Infect Dis 183:206-212. 2001
..Use of methods that decrease infant exposure to HIV-1 in maternal genital secretions or breast milk may enhance currently recommended perinatal HIV-1 interventions...
- The immunological components of human milk
Heather J Hosea Blewett
Department of Agricultural, Food and Nutritional Sciences, Alberta Institute for Human Nutrition, University of Alberta, Edmonton, Alberta, T6G 2P5, Canada
Adv Food Nutr Res 54:45-80. 2008
..However, we have yet to fully understand the complex mixture of bioactive compounds contained in human milk. Epidemiological studies have indicated that breast-feeding is associated with health benefits in the infant for ..
- Modulation of human intestinal epithelial cell IL-8 secretion by human milk factors
Erika C Claud
Developmental Gastroenterology Laboratory, Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
Pediatr Res 53:419-25. 2003
Necrotizing enterocolitis (NEC) seems to result from the inflammatory response of an immature intestine. Human milk is protective against NEC via an unknown mechanism...
- Maternal dietary PUFAs intake and human milk content relationships during the first month of lactation
Dept. of Neonatal Care, Genoa University, G. Gaslini Institute, Genova, Italy
Clin Nutr 20:393-7. 2001
Maternal dietary fatty acids (FFAs) intake and corresponding human milk composition relationships have been assessed throughout the first month of lactation in 34 lactating women consecutively enrolled...
- Innate recognition of bacteria in human milk is mediated by a milk-derived highly expressed pattern recognition receptor, soluble CD14
M O Labeta
Department of Medicine, University of Wales, College of Medicine, Heath Park, Cardiff CF4 4XX, United Kingdom
J Exp Med 191:1807-12. 2000
..These findings indicate a sentinel role for sCD14 in human milk during bacterial colonization of the gut, and suggest that m-sCD14 may be involved in modulating local innate ..
- Comparison of the cariogenicity of cola, honey, cow milk, human milk, and sucrose
William H Bowen
Center for Oral Biology, University of Rochester, Rochester, NY 14642, USA
Pediatrics 116:921-6. 2005
..We chose to examine sucrose, cola drink, honey, human milk, cow milk, and water because some of these have been associated with development of early childhood caries, ..
- Human milk-derived B cells: a highly activated switched memory cell population primed to secrete antibodies
Unité de Recherche EA 4205, Universite Montpellier 1, and Laboratoire de Virologie, Centre Hospitalier Universitaire de Montpellier, Montpellier, France
J Immunol 182:7155-62. 2009
..Breast milk B cells display a phenotype strikingly different from blood, are primed to secrete Abs, and have a mucosal homing profile similar to B cells located in gut-associated lymphoid tissue...
- Breastfeeding and the use of human milk
Lawrence M Gartner
Pediatrics 115:496-506. 2005
..The policy statement delineates various ways in which pediatricians can promote, protect, and support breastfeeding not only in their individual practices but also in the hospital, medical school, community, and nation...
- The immunological components of human milk and their effect on immune development in infants
Catherine J Field
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta T6G 2P5, Canada
J Nutr 135:1-4. 2005
There have been considerable advances in our understanding of the diverse mixture of bioactive components in human milk that influence the immune status of infants by not only providing protection but also facilitating development, ..
- Oligosaccharides in human milk: structural, functional, and metabolic aspects
Institut für Ernährung, Universitat Giessen, 35392 Giessen, Germany
Annu Rev Nutr 20:699-722. 2000
Research on human milk oligosaccharides (HMOs) has received much attention in recent years...
- MUC1 in human milk blocks transmission of human immunodeficiency virus from dendritic cells to T cells
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
Mol Immunol 46:2309-16. 2009
..We hypothesize that repetitive units of Lewis X, within the mucin domain, play an important role in inhibiting transmission of HIV-1 from mother to child...
- Neonatal protection by an innate immune system of human milk consisting of oligosaccharides and glycans
D S Newburg
Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA 02129, USA
J Anim Sci 87:26-34. 2009
This review discusses the role of human milk glycans in protecting infants, but the conclusion that the human milk glycans constitute an innate immune system whereby the mother protects her offspring may have general applicability in all ..
- Nutritional and physiologic significance of human milk proteins
Department of Nutrition, University of California, Davis, 95616, USA
Am J Clin Nutr 77:1537S-1543S. 2003
b>Human milk contains a wide variety of proteins that contribute to its unique qualities. Many of these proteins are digested and provide a well-balanced source of amino acids to rapidly growing infants...
- Genetic variants of the FADS1 FADS2 gene cluster are associated with altered (n-6) and (n-3) essential fatty acids in plasma and erythrocyte phospholipids in women during pregnancy and in breast milk during lactation
Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun, People s Republic of China
J Nutr 138:2222-8. 2008
..We showed that genetic variants of FADS1 and FADS2 influence blood lipid and breast milk essential fatty acids in pregnancy and lactation...
- Apoptosis induced by a human milk protein
Department of Medical Microbiology, Lund University, Sweden
Proc Natl Acad Sci U S A 92:8064-8. 1995
To the breast-fed infant, human milk is more than a source of nutrients; it furnishes a wide array of molecules that restrict microbes, such as antibodies, bactericidins, and inhibitors of bacterial adherence...
- Donor human milk versus formula for preventing necrotising enterocolitis in preterm infants: systematic review
Tayside Institute of Child Health, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
Arch Dis Child Fetal Neonatal Ed 88:F11-4. 2003
To determine if enteral feeding with donor human milk compared with formula milk reduces the incidence of necrotising enterocolitis (NEC) in preterm or low birthweight infants.
- Human milk oligosaccharides: prebiotics and beyond
Department of Pediatrics, University of California, San Diego School of Medicine, San Diego, California, USA
Nutr Rev 67:S183-91. 2009
b>Human milk oligosaccharides (HMO) are complex glycans that are present at very high concentrations in human milk but not in infant formula...
- Human milk protection against infectious diarrhea: implications for prevention and clinical care
Ardythe L Morrow
Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, 5041, Cincinnati, OH 45229 3039, USA
Semin Pediatr Infect Dis 15:221-8. 2004
..The protective effect of breastfeeding is attributable to a complex of acquired and innate factors unique to human milk that have anti-infective, anti-inflammatory, and immunoregulatory functions, including secretory antibodies, ..
- Near-infrared reflectance analysis to evaluate the nitrogen and fat content of human milk in neonatal intensive care units
Istituto Clinico di Pediatria Preventiva e Neonatologia, Policlinico S Orsola Malpighi, Universita di Bologna, Via Massarenti 11 40138 Bologna, Italy
Arch Dis Child Fetal Neonatal Ed 93:F372-5. 2008
To validate near-infrared reflectance analysis (NIRA) as a fast, reliable and suitable method for routine evaluation of human milk's nitrogen and fat content.
- Complete genome sequence of Lactobacillus fermentum CECT 5716, a probiotic strain isolated from human milk
Departamento de Nutricion, Bromatologia y Tecnologia de los Alimentos, Universidad Complutense de Madrid, Ciudad Universitaria, Madrid, Spain
J Bacteriol 192:4800. 2010
..Lactobacillus fermentum CECT 5716 is a well-characterized probiotic strain isolated from human milk and, at present, is used in commercial infant formulas...
- Purification from human milk of matriptase complexes with secreted serpins: mechanism for inhibition of matriptase other than HAI-1
I Chu Tseng
Greenebaum Cancer Ctr, Dept of Biochemistry and Molecular Biology, Univ of Maryland Baltimore, BRB 10 027, 655 W Baltimore St, Baltimore, MD 21201, USA
Am J Physiol Cell Physiol 295:C423-31. 2008
..In the present study, we characterized matriptase complexes of 110 kDa in human milk, which contained no HAI-1 and resisted dissociation in boiling SDS in the absence of reducing agents...
- Mother's own milk, donor human milk, and preterm formulas in the feeding of extremely premature infants
Richard J Schanler
Division of Neonatal Perinatal Medicine, Schneider Children s Hospital at North Shore, Manhasset, NY, USA
J Pediatr Gastroenterol Nutr 45:S175-7. 2007
..A reduction in infection-related morbidity in human milk-fed premature infants has been reported in nearly 1 dozen descriptive, and a few quasirandomized, studies in the ..
- Innate protection conferred by fucosylated oligosaccharides of human milk against diarrhea in breastfed infants
David S Newburg
Program in Glycobiology, Shriver Center, University of Massachusetts Medical School, Waltham, MA 02452, USA
Glycobiology 14:253-63. 2004
To test the hypothesis that human milk fucosyloligosaccharides are part of an innate immune system, we addressed whether their expression (1) depends on maternal genotype and (2) protects breastfed infants from pathogens...
- Glycoprofiling of bifidobacterial consumption of human milk oligosaccharides demonstrates strain specific, preferential consumption of small chain glycans secreted in early human lactation
Riccardo G LoCascio
Department of Viticulture and Enology, University of California Davis, Davis, California 95616, USA
J Agric Food Chem 55:8914-9. 2007
..After lactose and lipids, human milk oligosaccharides (HMOs) are quantitatively the third largest and most diverse component of breast milk...
- Amylolytic activity of IgG and sIgA immunoglobulins from human milk
T G Kanyshkova
Biophysics Department, St. Petersburg Technical University, St. Petersburg, Russia
Clin Chim Acta 314:141-52. 2001
BACKGROUND: New natural amylolytic abzymes (Abs) for catalytically active antibodies from human milk have been identified and investigated...
- Secretory immunoglobulin A from human milk catalyzes milk protein phosphorylation
G A Nevinsky
Novosibirsk Institute of Bioorganic Chemistry, Siberian Division of Russian Academy of Sciences, Russia
Appl Biochem Biotechnol 75:77-91. 1998
..In addition, the findings suggest the likelihood that catalytic Abs are generated by the immune system of healthy mothers...
- Human milk antibodies with polysaccharide kinase activity
Natal ya A Karataeva
Institute of Chemical Biology and Fundamental Medicine, Siberian Division of Russian Academy of Sciences, Lavrentieva Ave 8, Novosibirsk 630090, Russia
Immunol Lett 103:58-67. 2006
..Polysaccharide kinase sIgA of human milk is the third example of natural antibodies (Abs) with synthetic activity.
- Breast milk transmission of HIV-1. Laboratory and clinical studies
P Van de Perre
Centre Muraz, Organisation de Coordination et de Coopération pour la lutte contre les Grandes Endémies OCCGE, Bobo Dioulasso, Burkina Faso
Ann N Y Acad Sci 918:122-7. 2000
..Transmission of HIV-1 by breastfeeding has to be taken into account in designing interventions to reduce/prevent mother-to-child transmission in developing countries...
- Human milk glycosaminoglycans inhibit HIV glycoprotein gp120 binding to its host cell CD4 receptor
D S Newburg
Shriver Center for Mental Retardation, Waltham, MA 02254
J Nutr 125:419-24. 1995
..gp120, to its host cell receptor, CD4, is inhibited in a solid phase assay by a glycosaminoglycan of human milk; this binding is the essential first step in HIV infectivity...
- An exclusively human milk-based diet is associated with a lower rate of necrotizing enterocolitis than a diet of human milk and bovine milk-based products
Department of Pediatrics, University of Florida, Gainesville, FL, USA
J Pediatr 156:562-7.e1. 2010
To evaluate the health benefits of an exclusively human milk-based diet compared with a diet of both human milk and bovine milk-based products in extremely premature infants.
- Interleukin-10 and -12 in human milk at 3 stages of lactation: a longitudinal study
H Levent Yilmaz
Department of Pediatric Emergency Medicine, Medical Faculty of Cukurova University, Adana, Turkey
Adv Ther 24:603-10. 2007
..A total of 87 human milk samples were collected from 29 healthy mothers during the colostrum (0-3 days), early milk (14-17 days), and ..
- Isolation of bifidobacteria from breast milk and assessment of the bifidobacterial population by PCR-denaturing gradient gel electrophoresis and quantitative real-time PCR
Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands
Appl Environ Microbiol 75:965-9. 2009
..dentium. Bifidobacterial DNA was detected by qRTi-PCR in the same 22 milk samples at a range between 40 and 10,000 16S rRNA gene copies per ml. In conclusion, human milk seems to be a source of living bifidobacteria for the infant gut.
- Predominate HIV1-specific IgG activity in various mucosal compartments of HIV1-infected individuals
F X Lu
California Regional Primate Research Center, University of California, Davis, Davis, California, 95616, USA
Clin Immunol 97:59-68. 2000
- The nutritional iodine supply of Belgian neonates is still insufficient
Department of Paediatrics, Saint Pierre Hospital, University of Brussels, Brussels, Belgium
Eur J Pediatr 161:519-23. 2002
..Finally, the median urinary iodine increased from 60 micro g/l on day 5 to 150 micro g/l on day 30 in preterms bottle-fed with iodine-enriched formula-milk...
- Transfer of selected elements from food into human milk
International Graduate School of Zittau, Martk 23, D 02763 Zittau, Germany
Nutrition 18:316-22. 2002
..We measured the transfer factors of antimony, cerium, chromium, cobalt, gallium, lanthanum, molybdenum, niobium, ruthenium, silver, thorium, titanium, and uranium from food to milk in nursing mothers...
- Polysaccharide kinase activity of human milk IgG antibodies
N A Karataeva
Institute of Chemical and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, 630090 Novosibirsk, Russia
Biochemistry (Mosc) 71:1207-21. 2006
A small fraction of human milk IgG antibodies is shown to possess polysaccharide kinase activity for the first time...
- Human milk polyunsaturated long-chain fatty acids and secretory immunoglobulin A antibodies and early childhood allergy
Department of Health and Environment, Linkoping University Hospital, Sweden
Pediatr Allergy Immunol 11:29-39. 2000
..Besides the methodological problems, differences in the composition of human milk could explain these controversies...
- Human milk oligosaccharides are associated with protection against diarrhea in breast-fed infants
Ardythe L Morrow
Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
J Pediatr 145:297-303. 2004
..To determine the association between maternal milk levels of 2-linked fucosylated oligosaccharide and prevention of diarrhea as a result of Campylobacter, caliciviruses, and diarrhea of all causes in breast-fed infants...
- Longitudinal analysis of human immunodeficiency virus type 1 RNA in breast milk and of its relationship to infant infection and maternal disease
Christine M Rousseau
Department of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue, Seattle, WA 98109 1024, USA
J Infect Dis 187:741-7. 2003
..3-3.0; P<.001). These results indicate that the risk of infant infection from breast-feeding is influenced by breast-milk virus load, which is highest early after delivery...
- Isolation and characterization of human milk bile salt-activated lipase C-tail fragment
C S Wang
Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
Biochemistry 34:10639-44. 1995
..positions and oligosaccharide characteristics in the proline-rich, mucin-like, C-terminal region (C-tail) of human milk bile salt-activated lipase (BAL) were studied in order to assess the possible physiological functions of this ..
- Fatty acid composition abnormalities in atopic disease: evidence explored and role in the disease process examined
Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
Clin Exp Allergy 38:1432-50. 2008
- Breast-milk infectivity in human immunodeficiency virus type 1-infected mothers
Barbra A Richardson
Department of Biostatistics, University of Washington, Harborview Medical Center, Box 359909, 325 Ninth Avenue, Seattle, WA 98104 2499, USA
J Infect Dis 187:736-40. 2003
..The probability of HIV-1 infection per liter of breast milk ingested by an infant is similar in magnitude to the probability of heterosexual transmission of HIV-1 per unprotected sex act in adults...
- A critical review of methods for comparing estrogenic activity of endogenous and exogenous chemicals in human milk and infant formula
Christopher J Borgert
Applied Pharmacology and Toxicology, Inc, Alachua, Florida, USA
Environ Health Perspect 111:1020-36. 2003
The two primary sources of nutrition for infants are human milk and infant formula. Both contain an array of endogenous and exogenous chemicals that may act through many separate hormonal mechanisms...
- Antiinfective properties of human milk
Department of Neonatology and Neonatal Intensive Care, Spedali Civili, 25123 Brescia, Italy
J Nutr 138:1801S-1806S. 2008
..occurring compensatory mechanisms, such as the introduction of protective and immunological components of human milk in the infant...
- Protection of the neonate by the innate immune system of developing gut and of human milk
David S Newburg
Pediatric Gastroenterology and Nutrition Unit, MassGeneral Hospital for Children and Harvard Medical School, Boston, Massachusetts, USA
Pediatr Res 61:2-8. 2007
..Enteric neurons and lymphocytes provide paracrine and endocrine signaling. However, full protection requires human milk. Breast-feeding reduces enteric infection and may reduce chronic disease in later life...
- Individual characteristics associated with PBDE levels in U.S. human milk samples
Julie L Daniels
Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, North Carolina 27599 7435, USA
Environ Health Perspect 118:155-60. 2010
..Reported polybrominated diphenyl ether (PBDE) concentrations in human samples in the United States have been higher than in Europe and Asia. Little is known about factors that contribute to individual variability in body burden...
- FADS1 FADS2 gene variants modify the association between fish intake and the docosahexaenoic acid proportions in human milk
Department of Nutrition and Food Science, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain
Am J Clin Nutr 91:1368-76. 2010
..Docosahexaenoic acid (DHA) can be supplied especially by dietary fish or fish oil and synthesized from alpha-linolenic acid through a pathway involving these desaturases...
- Free glutamine and glutamic acid increase in human milk through a three-month lactation period
Department of Pediatrics, San Paolo Hospital, Milan, Italy
J Pediatr Gastroenterol Nutr 31:508-12. 2000
Previous short observational studies on the free amino acid (FAA) content of human milk have shown that glutamine and glutamic acid increase in the first 4 to 6 weeks of life.
- Breast-feeding and cognitive development: a meta-analysis
J W Anderson
Metabolic Research Group, Veterans Affairs Medical Center
Am J Clin Nutr 70:525-35. 1999
- Trefoil factors in human milk
Else Marie Vestergaard
Department of Clinical Biochemistry, Aarhus University Hospital Skejby, Aarhus, Denmark
Early Hum Dev 84:631-5. 2008
We measured concentrations of the gastrointestinal protective peptides Trefoil factors in human milk. By the use of in-house ELISA we detected high amounts of TFF3, less TFF1 and virtually no TFF2 in human breast milk obtained from 46 ..
- Fucosylated human milk oligosaccharides vary between individuals and over the course of lactation
Shriver Center for Mental Retardation, Waltham, MA 02452, USA
Glycobiology 11:365-72. 2001
Specific human milk oligosaccharides, especially fucosylated neutral oligosaccharides, protect infants against specific microbial pathogens...
- Exposure assessment of French women and their newborn to brominated flame retardants: determination of tri- to deca- polybromodiphenylethers (PBDE) in maternal adipose tissue, serum, breast milk and cord serum
Jean Philippe Antignac
LABoratoire d Etude des Résidus et Contaminants dans les Aliments, USC INRA 2013, Ecole Nationale Veterinaire de Nantes, Route de Gachet, BP 50707, 44307 Nantes Cedex 3, France
Environ Pollut 157:164-73. 2009
..At this opposite, median levels of octa- to decaBDE in maternal and cord serum appeared significantly higher than the levels of tri- to heptaBDE in the same matrices, i.e. 8.85 and 12.34 versus 0.98 and 0.69 ng g(-1) l w, respectively...
- Breast-feeding and Transmission of HIV-1
Department of Medicine, University of Washington, USA
J Acquir Immune Defic Syndr 35:196-202. 2004
..Innate and acquired immune factors may act most effectively in combination to prevent primary HIV-1 infection by breast milk...
- Semiautomated high-throughput extraction and cleanup method for the measurement of polybrominated diphenyl ethers and polybrominated and polychlorinated biphenyls in breast milk
National Center for Environmental Health, Division of Laboratory Sciences, Organic Analytical Toxicology Branch, Centers for Disease Control and Prevention, 4770 Buford Hwy NE Mail Stop F 17, Atlanta, Georgia 30341, USA
Anal Chem 76:4508-14. 2004
..Mean recoveries of the (13)C-labeled internal standards ranged from 60 to 89% for the eight PBDE congeners; 74 and 113% were recovered for BB-153 and CB-153, respectively...
- The immune system in human milk and the developing infant
Armond S Goldman
Department of Pediatrics, The University of Texas Medical Branch, Galveston, Texas 77555 0369, USA
Breastfeed Med 2:195-204. 2007
The concept of the immune system in human milk emerged in the 1970s from clinical and laboratory observations made between the late 18th through the mid-20th centuries...
- Human milk compounds inhibiting adhesion of mutans streptococci to host ligand-coated hydroxyapatite in vitro
L Danielsson Niemi
Department of Odontology Cariology, Umea University, Umea, Sweden
Caries Res 43:171-8. 2009
..Following our recent finding that human milk may inhibit adhesion of Streptococcus mutans the aim of the present study was to identify compounds in human ..
- Human milk fatty acid composition from nine countries varies most in DHA
Department of Nutrition Research, Wyeth Nutrition, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
Lipids 41:851-8. 2006
..The results of this study demonstrate that the proportion of saturated and monounsaturated FA are relatively constant across a large number of countries, whereas the level of some of the PUFA, especially DHA, are highly variable...
- Advances in our understanding of the biology of human milk and its effects on the offspring
Department of Human Nutrition, Faculty of Life Science, University of Copenhagen, DK 1958, Frederiksberg C, Denmark
J Nutr 137:503S-510S. 2007
..Recent data have suggested that breast-feeding can program the insulin-like growth factor-I axis, as 3 studies found that breast-fed infants are taller as adults...
- Role of human milk in extremely low birth weight infants' risk of necrotizing enterocolitis or death
Division of Neonatology, Department of Pediatrics, Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
J Perinatol 29:57-62. 2009
To determine the association between human milk (HM) intake and risk of necrotizing enterocolitis (NEC) or death among infants 401 to 1000 g birth weight.
- Differential transcriptional response of Bifidobacterium longum to human milk, formula milk, and galactooligosaccharide
Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, The Netherlands
Appl Environ Microbiol 74:4686-94. 2008
..in breast milk and included putative genes for N-acetylglucosamine degradation and for metabolism of mucin and human milk oligosaccharides via the galactose/lacto-N-biose gene cluster...
- Innate immunity and human milk
David S Newburg
Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Charlestown, MA, USA
J Nutr 135:1308-12. 2005
..Thus, the innate immune system of human milk is an important complement to the mucosal barrier of the developing gut...
- Human exposure to PBDEs: associations of PBDE body burdens with food consumption and house dust concentrations
Department of Environmental Health Talbot 2E, Boston University School of Public Health, 715 Albany Street, Boston, Massachusetts 02118, USA
Environ Sci Technol 41:1584-9. 2007
..Our results support the hypothesis that the indoor environment and diet both play prominent roles in adult human exposure to PBDEs...
- Salivary secretory leukocyte protease inhibitor is associated with reduced transmission of human immunodeficiency virus type 1 through breast milk
Departments of Medicine, Epidemiology, and Biostatistics, University of Washington, 325 Ninth Avenue, Seattle, WA 98104 2499, USA
J Infect Dis 186:1173-6. 2002
..5; 95% confidence interval, 0.3-0.9; P=.03). These results suggest that SLPI plays an important role in reducing HIV-1 transmission through breast milk...
- Human milk proteins: an interactomics and updated functional overview
Department of Environmental Sciences, University of Tuscia, Largo dell Universita, snc, 01100 Viterbo, Italy
J Proteome Res 9:3339-73. 2010
..and pathway and network analyses, we merged data from literature dealing with protein-oriented studies on human milk. A total of 285 entries defined a nonredundant list upon comparison with the Ingenuity Knowledge Base from the ..
- Human milk proteins: key components for the biological activity of human milk
Department of Nutrition and Program of International Nutrition, University of California, Davis, CA 95616, USA
Adv Exp Med Biol 554:11-25. 2004
b>Human milk contains a wide array of proteins that provide biologic activities ranging from antimicrobial effects to immunostimulatory functions...
- Evaluation of xenobiotics in human milk and ingestion by the newborn--an epidemiological survey in Lombardy (Northern Italy)
Department of Applied Health and Psycho behavioural Sciences, Section of Human Nutrition Faculty of Medicine, University of Pavia, via Bassi 21, 27100, Italy
Eur J Nutr 43:191-7. 2004
Many human milk benefits have been well documented; nevertheless the newborn potential risk to the xenobiotic exposition may be relevant and it requires a biological monitoring in general prevention...
- Physiological aspects of human milk lipids
Department of Pediatrics, Kinderklinik and Kinderpoliklinik, Dr von Haunersches Kinderspitel, Ludwig Maximilians University of Munich, Lindwurmstr 4, D 80337, Munich, Germany
Early Hum Dev 65:S3-S18. 2001
b>Human milk from healthy and well-nourished mothers is the preferred form of feeding for all healthy newborn infants. The nutrient supply with human milk supports normal growth and development of the infant...
- Structural basis for the interaction between human milk oligosaccharides and the bacterial lectin PA-IIL of Pseudomonas aeruginosa
Centre de Recherches sur les Macromolecules Vegetales, CNRS, Universite Joseph Fourier, BP53, 38041 Grenoble Cedex 09, France
Biochem J 389:325-32. 2005
..to the protection by breast-feeding of the newborn against enteric diseases is related to the ability of human milk oligosaccharides to prevent the attachment of pathogenic bacteria to the duodenual epithelium...
- Structural analysis of underivatized neutral human milk oligosaccharides in the negative ion mode by nano-electrospray MS(n) (part 1: methodology)
Institute of Pharmaceutical Chemistry, J W Goethe University, Frankfurt Main, Germany
J Am Soc Mass Spectrom 13:1331-40. 2002
Underivatized neutral oligosaccharides from human milk were analyzed by nano-electrospray ionization (ESI) using a quadrupole ion trap mass spectrometer (QIT-MS) in the negative-ion mode...
- Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children's IQ at 4 years of age
Ingrid B Helland
Institute for Nutrition Research, University of Oslo, Oslo, Norway Peter Möller, avd Orkla, ASA, Oslo, Norway
Pediatrics 111:e39-44. 2003
- Metabolism of phthalates in humans
Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
Mol Nutr Food Res 51:899-911. 2007
..This differential distribution is of special concern as, in particular, the hydrophobic phthalates and their metabolites are shown to have adverse effects following in utero and lactational exposures in animal studies...
- Bifidobacterium bifidum lacto-N-biosidase, a critical enzyme for the degradation of human milk oligosaccharides with a type 1 structure
Graduate School of Biostudies, Kyoto University, Kitashirakawa, Sakyo ku, Kyoto 606 8502, Japan
Appl Environ Microbiol 74:3996-4004. 2008
..type 1 chain) from lacto-N-tetraose (Galbeta1,3GlcNAcbeta1,3Galbeta1,4Glc), which is a major component of human milk oligosaccharides, and subsequently isolated the gene from Bifidobacterium bifidum JCM1254...
- Comparing water, bovine milk, and indoor residual spraying as possible sources of DDT and pyrethroid residues in breast milk
Agricultural Research Council, Plant Protection Research Institute, Pretoria, South Africa
J Toxicol Environ Health A 72:842-51. 2009
- Human milk: maternal dietary lipids and infant development
Sheila M Innis
Nutrition Research Program, Child and Family Research Institute, University of British Columbia, 950 West 28th Avenue, Vancouver, BC V5Z 4H4, Canada
Proc Nutr Soc 66:397-404. 2007
b>Human milk provides all the dietary essential fatty acids, linoleic acid (LA; 18:2n-6) and alpha-linolenic acid (18:3n-3), as well as their longer-chain more-unsaturated metabolites, including arachidonic acid (20:4n-6) and DHA (22:6n-3) ..
- A strategy for annotating the human milk glycome
Milady R Ninonuevo
Department of Chemistry and Biochemistry School of Medicine, University of California, Davis, California 95616, USA
J Agric Food Chem 54:7471-80. 2006
Oligosaccharides in human milk represent a group of bioactive molecules that have evolved to be an abundant and diverse component of human milk, even though they have no direct nutritive value to the infant...
- Perfluorinated compounds in human milk from Massachusetts, U.S.A
Wadsworth Center, New York State Department of Health, Albany, New York, USA
Environ Sci Technol 42:3096-101. 2008
..8 pg/mL, respectively. Comparison of the ratio of PFOS to PFOA in human milk with the ratios published for human serum from the U.S...
- Flash-heat inactivation of HIV-1 in human milk: a potential method to reduce postnatal transmission in developing countries
Division of Epidemiology, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
J Acquir Immune Defic Syndr 45:318-23. 2007
..The World Health Organization recommends heat-treated breast milk as an infant-feeding alternative. We investigated the ability of a simple method, flash-heat, to inactivate HIV in breast milk from HIV-positive mothers...
- Insulin in human milk: postpartum changes and effect of gestational age
Department of Neonatology, Meyer Children s Hospital, Rambam Medical Center, Bat Galim, Haifa 31096, Israel
Arch Dis Child Fetal Neonatal Ed 88:F214-6. 2003
To determine if human milk insulin (HMI) concentrations are affected by gestational age and postnatal age.
- Determination of polycyclic aromatic hydrocarbons (PAHs) and total fats in human milk
Massimo Del Bubba
Department of Chemistry University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence Italy
Ann Chim 95:629-41. 2005
..method was developed for the simultaneous extraction of PAHs and total fats and their determination in the human milk. The method involved a liquid-liquid extraction of PAHs and fats, followed by the gravimetric determination of ..
- Organochlorine pesticide residues in human milk of a Hmong hill tribe living in Northern Thailand
Institute of Biological Chemistry and Nutrition, University of Hohenheim, Stuttgart, Germany
Sci Total Environ 273:53-60. 2001
- [Polybrominated diphenyl ether flame retardants in foodstuffs and human milk]
Osaka Prefectural Institute of Public Health 1 3 69, Nakamichi, Higashinari ku, Osaka 537 0025, Japan
Shokuhin Eiseigaku Zasshi 45:175-83. 2004
..In this review, published information on the toxicology of PBDEs, levels in foodstuffs and human milk, and analytical methods has been compiled.
- Development of an annotated library of neutral human milk oligosaccharides
Department of Chemistry, University of California, Davis, California 95616, USA
J Proteome Res 9:4138-51. 2010
b>Human milk oligosaccharides (HMOs) perform a number of functions including serving as prebiotics to stimulate the growth of beneficial intestinal bacteria, as receptor analogues to inhibit binding of pathogens, and as substances that ..
- Exposure patterns of UV filters, fragrances, parabens, phthalates, organochlor pesticides, PBDEs, and PCBs in human milk: correlation of UV filters with use of cosmetics
GREEN Tox and Institute of Anatomy, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland
Chemosphere 81:1171-83. 2010
..We present data on chemicals in human milk of a cohort study (2004, 2005, 2006) of 54 mother/child pairs, where for the first time, cosmetic UV filters, ..
- Analysis of high-molecular-weight oligosaccharides from human milk by liquid chromatography and MALDI-MS
Milupa Research, Milupa GmbH and Company KG, Friedrichsdorf, Germany
Anal Chem 71:3755-62. 1999
Pooled human milk oligosaccharides were fractionated by anion-exchange chromatography on AG 1-X2 and by an improved gel filtration procedure that allowed the separation of large oligosaccharides on Toyopearl HW 40 (S) and Bio-Gel P-6 ..
- The influence of sardine consumption on the omega-3 fatty acid content of mature human milk
Rose V Patin
Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil
J Pediatr (Rio J) 82:63-9. 2006
..The purpose of this study was to investigate what effect the ingestion of sardines, rich in omega-3 series polyunsaturated fatty acids, has on the composition of breastmilk...
- Timing of breast milk HIV-1 transmission: a meta-analysis
G C John
Departments of Medicine, Epidemiology, and Biostatistics, University of Washington, Seattle, Washington 98195, USA
East Afr Med J 78:75-9. 2001
..While recently published studies showing some effectiveness of antiretrovirals early during the breast feeding period are encouraging, prevention of breast milk HIV-1 transmission needs to remain a high research priority...
- Folate contents in human milk and casein-based and soya-based formulas, and folate status in Korean infants
Young Hee Han
Department of Food and Nutrition, Chungbuk National University, Cheongju, Korea
Br J Nutr 101:1769-74. 2009
We assessed folate nutritional status from birth to 12 months in fifty-one infants who were fed human milk (HM; n 20), casein-based formula (CBF; n 12) or soya-based formula (SBF; n 19)...
- Reflections on the American Academy of Pediatrics' 2005 policy statement on "Breastfeeding and the use of human milk"
J Hum Lact 22:108-10. 2006
- Human milk oligosaccharides inhibit the adhesion to Caco-2 cells of diarrheal pathogens: Escherichia coli, Vibrio cholerae, and Salmonella fyris
Giovanni V Coppa
Institute of Maternal Infantile Sciences, Polytechnic University of Marche, Italy
Pediatr Res 59:377-82. 2006
..ones, have a lower incidence of acute gastroenteritis due to the presence of several antiinfective factors in human milk. The aim of this work is to study the ability of human milk oligosaccharides to prevent infections related to ..
- A low-molecular-weight factor in human milk whey promotes iron uptake by Caco-2 cells
Department of Food Science, Cornell University, Ithaca, NY 14853, USA
J Nutr 134:93-8. 2004
The iron bioavailability of human milk (HM) is substantially greater than that of cow's milk (CM), but the factor responsible for this high bioavailability is unknown...
- The effect of calcium salts, ascorbic acid and peptic pH on calcium, zinc and iron bioavailabilities from fortified human milk using an in vitro digestion/Caco-2 cell model
Department of Food Science, Stocking Hall, Cornell University, Ithaca, NY 14853, USA
Int J Vitam Nutr Res 75:171-8. 2005
The calcium, zinc, and iron bioavailabilities of human milk with commercial and noncommercial human milk fortifiers (HMFs) were evaluated under a variety of conditions: peptic digestion at pH 2 and pH 4, supplementation of ascorbic acid, ..
- Honey and royal jelly, like human milk, abrogate lectin-dependent infection-preceding Pseudomonas aeruginosa adhesion
The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
ISME J 1:149-55. 2007
..Such compounds were found in human milk (HM) and avian egg whites...
- Conjugated linoleic acid determination in human milk by fast-gas chromatography
Department of Nutrition and Food Science, Food Technology Reference Centre, Faculty of Pharmacy, University of Barcelona, Av Joan XXIII s n E 08028 Barcelona, Spain
Anal Chim Acta 602:122-30. 2007
..S.D.) of repeatability and reproducibility ranging between 0.10 and 8.71%. The application of this method to human and rat milk samples showed that it was a rapid, simple and reliable method for the analysis of biological samples...
- DDT, DDE and DDD in human milk from South Africa
Jonathan Okechukwu Okonkwo
Tshwane University of Technology, Pretoria, South Africa
Bull Environ Contam Toxicol 81:348-54. 2008
..The SigmaDDT was found to decrease with increasing age of the mothers. The observed high levels of DDE compared to DDT indicated chronic exposure of the mothers to DDT, which is metabolised to DDE and retained in the body...
- Fatty acid composition of human milk in atopic Danish mothers
Department of Human Nutrition, Center for Advanced Food Studies, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
Am J Clin Nutr 84:190-6. 2006
..Atopic dermatitis has been related to a disturbed metabolism of polyunsaturated fatty acids (PUFAs)...
- Human milk oligosaccharides reduce platelet-neutrophil complex formation leading to a decrease in neutrophil beta 2 integrin expression
Institute of Nutritional Science, Justus Liebig University Giessen, Germany
J Leukoc Biol 76:820-6. 2004
b>Human milk is thought by many authorities to be preferable to formula as a source of nutrients for infants. Some of the benefits may stem from its high concentration of unbound oligosaccharides (5-10 g/L)...
- Activity against Listeria monocytogenes of human milk during lactation. A preliminary study
Instituto de Fermentaciones Industriales CSIC C Juan de la Cierva, 3, 28006 Madrid, Spain
J Dairy Res 75:24-9. 2008
b>Human milk samples from three healthy donors were investigated in order to evaluate the antibacterial activity during lactation against Escherichia coli ATCC 25922 and Listeria monocytogenes...
- Nutrient composition of human milk
M F Picciano
Department of Nutrition, Pennsylvania State University, University Park, Pennsylvania, USA
Pediatr Clin North Am 48:53-67. 2001
..Investigations provide evidence that human milk possesses many unique characteristics and that maternal and environmental influences are stronger than ..