human milk

Summary

Top Publications

  1. pmc Polybrominated diphenyl ethers: occurrence, dietary exposure, and toxicology
    P O Darnerud
    National Food Administration, Toxicology Division, Uppsala, Sweden
    Environ Health Perspect 109:49-68. 2001
  2. pmc Bile salt-stimulated lipase from human milk binds DC-SIGN and inhibits human immunodeficiency virus type 1 transfer to CD4+ T cells
    Marloes A Naarding
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    Antimicrob Agents Chemother 50:3367-74. 2006
  3. pmc Consumption of human milk oligosaccharides by gut-related microbes
    Angela Marcobal
    Department of Viticulture and Enology, University of California, Davis, California 95616, USA
    J Agric Food Chem 58:5334-40. 2010
  4. ncbi Correlates of mother-to-child human immunodeficiency virus type 1 (HIV-1) transmission: association with maternal plasma HIV-1 RNA load, genital HIV-1 DNA shedding, and breast infections
    G C John
    Department of Medicine, University of Washington, Seattle, WA, USA
    J Infect Dis 183:206-212. 2001
  5. ncbi The immunological components of human milk
    Heather J Hosea Blewett
    Department of Agricultural, Food and Nutritional Sciences, Alberta Institute for Human Nutrition, University of Alberta, Edmonton, Alberta, T6G 2P5, Canada
    Adv Food Nutr Res 54:45-80. 2008
  6. ncbi Modulation of human intestinal epithelial cell IL-8 secretion by human milk factors
    Erika C Claud
    Developmental Gastroenterology Laboratory, Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Pediatr Res 53:419-25. 2003
  7. ncbi Maternal dietary PUFAs intake and human milk content relationships during the first month of lactation
    F Scopesi
    Dept. of Neonatal Care, Genoa University, G. Gaslini Institute, Genova, Italy
    Clin Nutr 20:393-7. 2001
  8. pmc Innate recognition of bacteria in human milk is mediated by a milk-derived highly expressed pattern recognition receptor, soluble CD14
    M O Labeta
    Department of Medicine, University of Wales, College of Medicine, Heath Park, Cardiff CF4 4XX, United Kingdom
    J Exp Med 191:1807-12. 2000
  9. ncbi Comparison of the cariogenicity of cola, honey, cow milk, human milk, and sucrose
    William H Bowen
    Center for Oral Biology, University of Rochester, Rochester, NY 14642, USA
    Pediatrics 116:921-6. 2005
  10. ncbi Human milk-derived B cells: a highly activated switched memory cell population primed to secrete antibodies
    Edouard Tuaillon
    Unité de Recherche EA 4205, Universite Montpellier 1, and Laboratoire de Virologie, Centre Hospitalier Universitaire de Montpellier, Montpellier, France
    J Immunol 182:7155-62. 2009

Detail Information

Publications289 found, 100 shown here

  1. pmc Polybrominated diphenyl ethers: occurrence, dietary exposure, and toxicology
    P O Darnerud
    National Food Administration, Toxicology Division, Uppsala, Sweden
    Environ Health Perspect 109:49-68. 2001
    ..Moreover, the time trend of PBDEs in human breast milk is alarming for the future...
  2. pmc Bile salt-stimulated lipase from human milk binds DC-SIGN and inhibits human immunodeficiency virus type 1 transfer to CD4+ T cells
    Marloes A Naarding
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    Antimicrob Agents Chemother 50:3367-74. 2006
    ..We have previously demonstrated that a multimeric LeX component in human milk binds to DC-SIGN, preventing HIV-1 from interacting with this receptor...
  3. pmc Consumption of human milk oligosaccharides by gut-related microbes
    Angela Marcobal
    Department of Viticulture and Enology, University of California, Davis, California 95616, USA
    J Agric Food Chem 58:5334-40. 2010
    b>Human milk contains large amounts of complex oligosaccharides that putatively modulate the intestinal microbiota of breast-fed infants by acting as decoy binding sites for pathogens and as prebiotics for enrichment of beneficial bacteria...
  4. ncbi Correlates of mother-to-child human immunodeficiency virus type 1 (HIV-1) transmission: association with maternal plasma HIV-1 RNA load, genital HIV-1 DNA shedding, and breast infections
    G C John
    Department of Medicine, University of Washington, Seattle, WA, USA
    J Infect Dis 183:206-212. 2001
    ..Use of methods that decrease infant exposure to HIV-1 in maternal genital secretions or breast milk may enhance currently recommended perinatal HIV-1 interventions...
  5. ncbi The immunological components of human milk
    Heather J Hosea Blewett
    Department of Agricultural, Food and Nutritional Sciences, Alberta Institute for Human Nutrition, University of Alberta, Edmonton, Alberta, T6G 2P5, Canada
    Adv Food Nutr Res 54:45-80. 2008
    ..However, we have yet to fully understand the complex mixture of bioactive compounds contained in human milk. Epidemiological studies have indicated that breast-feeding is associated with health benefits in the infant for ..
  6. ncbi Modulation of human intestinal epithelial cell IL-8 secretion by human milk factors
    Erika C Claud
    Developmental Gastroenterology Laboratory, Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Pediatr Res 53:419-25. 2003
    Necrotizing enterocolitis (NEC) seems to result from the inflammatory response of an immature intestine. Human milk is protective against NEC via an unknown mechanism...
  7. ncbi Maternal dietary PUFAs intake and human milk content relationships during the first month of lactation
    F Scopesi
    Dept. of Neonatal Care, Genoa University, G. Gaslini Institute, Genova, Italy
    Clin Nutr 20:393-7. 2001
    Maternal dietary fatty acids (FFAs) intake and corresponding human milk composition relationships have been assessed throughout the first month of lactation in 34 lactating women consecutively enrolled...
  8. pmc Innate recognition of bacteria in human milk is mediated by a milk-derived highly expressed pattern recognition receptor, soluble CD14
    M O Labeta
    Department of Medicine, University of Wales, College of Medicine, Heath Park, Cardiff CF4 4XX, United Kingdom
    J Exp Med 191:1807-12. 2000
    ..These findings indicate a sentinel role for sCD14 in human milk during bacterial colonization of the gut, and suggest that m-sCD14 may be involved in modulating local innate ..
  9. ncbi Comparison of the cariogenicity of cola, honey, cow milk, human milk, and sucrose
    William H Bowen
    Center for Oral Biology, University of Rochester, Rochester, NY 14642, USA
    Pediatrics 116:921-6. 2005
    ..We chose to examine sucrose, cola drink, honey, human milk, cow milk, and water because some of these have been associated with development of early childhood caries, ..
  10. ncbi Human milk-derived B cells: a highly activated switched memory cell population primed to secrete antibodies
    Edouard Tuaillon
    Unité de Recherche EA 4205, Universite Montpellier 1, and Laboratoire de Virologie, Centre Hospitalier Universitaire de Montpellier, Montpellier, France
    J Immunol 182:7155-62. 2009
    ..Breast milk B cells display a phenotype strikingly different from blood, are primed to secrete Abs, and have a mucosal homing profile similar to B cells located in gut-associated lymphoid tissue...
  11. ncbi Breastfeeding and the use of human milk
    Lawrence M Gartner
    Pediatrics 115:496-506. 2005
    ..The policy statement delineates various ways in which pediatricians can promote, protect, and support breastfeeding not only in their individual practices but also in the hospital, medical school, community, and nation...
  12. ncbi The immunological components of human milk and their effect on immune development in infants
    Catherine J Field
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta T6G 2P5, Canada
    J Nutr 135:1-4. 2005
    There have been considerable advances in our understanding of the diverse mixture of bioactive components in human milk that influence the immune status of infants by not only providing protection but also facilitating development, ..
  13. ncbi Oligosaccharides in human milk: structural, functional, and metabolic aspects
    C Kunz
    Institut für Ernährung, Universitat Giessen, 35392 Giessen, Germany
    Annu Rev Nutr 20:699-722. 2000
    Research on human milk oligosaccharides (HMOs) has received much attention in recent years...
  14. ncbi MUC1 in human milk blocks transmission of human immunodeficiency virus from dendritic cells to T cells
    Eirikur Saeland
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Mol Immunol 46:2309-16. 2009
    ..We hypothesize that repetitive units of Lewis X, within the mucin domain, play an important role in inhibiting transmission of HIV-1 from mother to child...
  15. ncbi Neonatal protection by an innate immune system of human milk consisting of oligosaccharides and glycans
    D S Newburg
    Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA 02129, USA
    J Anim Sci 87:26-34. 2009
    This review discusses the role of human milk glycans in protecting infants, but the conclusion that the human milk glycans constitute an innate immune system whereby the mother protects her offspring may have general applicability in all ..
  16. ncbi Nutritional and physiologic significance of human milk proteins
    Bo Lonnerdal
    Department of Nutrition, University of California, Davis, 95616, USA
    Am J Clin Nutr 77:1537S-1543S. 2003
    b>Human milk contains a wide variety of proteins that contribute to its unique qualities. Many of these proteins are digested and provide a well-balanced source of amino acids to rapidly growing infants...
  17. ncbi Genetic variants of the FADS1 FADS2 gene cluster are associated with altered (n-6) and (n-3) essential fatty acids in plasma and erythrocyte phospholipids in women during pregnancy and in breast milk during lactation
    Lin Xie
    Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun, People s Republic of China
    J Nutr 138:2222-8. 2008
    ..We showed that genetic variants of FADS1 and FADS2 influence blood lipid and breast milk essential fatty acids in pregnancy and lactation...
  18. pmc Apoptosis induced by a human milk protein
    A Hakansson
    Department of Medical Microbiology, Lund University, Sweden
    Proc Natl Acad Sci U S A 92:8064-8. 1995
    To the breast-fed infant, human milk is more than a source of nutrients; it furnishes a wide array of molecules that restrict microbes, such as antibodies, bactericidins, and inhibitors of bacterial adherence...
  19. pmc Donor human milk versus formula for preventing necrotising enterocolitis in preterm infants: systematic review
    W McGuire
    Tayside Institute of Child Health, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
    Arch Dis Child Fetal Neonatal Ed 88:F11-4. 2003
    To determine if enteral feeding with donor human milk compared with formula milk reduces the incidence of necrotising enterocolitis (NEC) in preterm or low birthweight infants.
  20. ncbi Human milk oligosaccharides: prebiotics and beyond
    Lars Bode
    Department of Pediatrics, University of California, San Diego School of Medicine, San Diego, California, USA
    Nutr Rev 67:S183-91. 2009
    b>Human milk oligosaccharides (HMO) are complex glycans that are present at very high concentrations in human milk but not in infant formula...
  21. ncbi Human milk protection against infectious diarrhea: implications for prevention and clinical care
    Ardythe L Morrow
    Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, 5041, Cincinnati, OH 45229 3039, USA
    Semin Pediatr Infect Dis 15:221-8. 2004
    ..The protective effect of breastfeeding is attributable to a complex of acquired and innate factors unique to human milk that have anti-infective, anti-inflammatory, and immunoregulatory functions, including secretory antibodies, ..
  22. ncbi Near-infrared reflectance analysis to evaluate the nitrogen and fat content of human milk in neonatal intensive care units
    L Corvaglia
    Istituto Clinico di Pediatria Preventiva e Neonatologia, Policlinico S Orsola Malpighi, Universita di Bologna, Via Massarenti 11 40138 Bologna, Italy
    Arch Dis Child Fetal Neonatal Ed 93:F372-5. 2008
    To validate near-infrared reflectance analysis (NIRA) as a fast, reliable and suitable method for routine evaluation of human milk's nitrogen and fat content.
  23. pmc Complete genome sequence of Lactobacillus fermentum CECT 5716, a probiotic strain isolated from human milk
    Esther Jiménez
    Departamento de Nutricion, Bromatologia y Tecnologia de los Alimentos, Universidad Complutense de Madrid, Ciudad Universitaria, Madrid, Spain
    J Bacteriol 192:4800. 2010
    ..Lactobacillus fermentum CECT 5716 is a well-characterized probiotic strain isolated from human milk and, at present, is used in commercial infant formulas...
  24. pmc Purification from human milk of matriptase complexes with secreted serpins: mechanism for inhibition of matriptase other than HAI-1
    I Chu Tseng
    Greenebaum Cancer Ctr, Dept of Biochemistry and Molecular Biology, Univ of Maryland Baltimore, BRB 10 027, 655 W Baltimore St, Baltimore, MD 21201, USA
    Am J Physiol Cell Physiol 295:C423-31. 2008
    ..In the present study, we characterized matriptase complexes of 110 kDa in human milk, which contained no HAI-1 and resisted dissociation in boiling SDS in the absence of reducing agents...
  25. ncbi Mother's own milk, donor human milk, and preterm formulas in the feeding of extremely premature infants
    Richard J Schanler
    Division of Neonatal Perinatal Medicine, Schneider Children s Hospital at North Shore, Manhasset, NY, USA
    J Pediatr Gastroenterol Nutr 45:S175-7. 2007
    ..A reduction in infection-related morbidity in human milk-fed premature infants has been reported in nearly 1 dozen descriptive, and a few quasirandomized, studies in the ..
  26. ncbi Innate protection conferred by fucosylated oligosaccharides of human milk against diarrhea in breastfed infants
    David S Newburg
    Program in Glycobiology, Shriver Center, University of Massachusetts Medical School, Waltham, MA 02452, USA
    Glycobiology 14:253-63. 2004
    To test the hypothesis that human milk fucosyloligosaccharides are part of an innate immune system, we addressed whether their expression (1) depends on maternal genotype and (2) protects breastfed infants from pathogens...
  27. ncbi Glycoprofiling of bifidobacterial consumption of human milk oligosaccharides demonstrates strain specific, preferential consumption of small chain glycans secreted in early human lactation
    Riccardo G LoCascio
    Department of Viticulture and Enology, University of California Davis, Davis, California 95616, USA
    J Agric Food Chem 55:8914-9. 2007
    ..After lactose and lipids, human milk oligosaccharides (HMOs) are quantitatively the third largest and most diverse component of breast milk...
  28. ncbi Amylolytic activity of IgG and sIgA immunoglobulins from human milk
    T G Kanyshkova
    Biophysics Department, St. Petersburg Technical University, St. Petersburg, Russia
    Clin Chim Acta 314:141-52. 2001
    BACKGROUND: New natural amylolytic abzymes (Abs) for catalytically active antibodies from human milk have been identified and investigated...
  29. ncbi Secretory immunoglobulin A from human milk catalyzes milk protein phosphorylation
    G A Nevinsky
    Novosibirsk Institute of Bioorganic Chemistry, Siberian Division of Russian Academy of Sciences, Russia
    Appl Biochem Biotechnol 75:77-91. 1998
    ..In addition, the findings suggest the likelihood that catalytic Abs are generated by the immune system of healthy mothers...
  30. ncbi Human milk antibodies with polysaccharide kinase activity
    Natal ya A Karataeva
    Institute of Chemical Biology and Fundamental Medicine, Siberian Division of Russian Academy of Sciences, Lavrentieva Ave 8, Novosibirsk 630090, Russia
    Immunol Lett 103:58-67. 2006
    ..Polysaccharide kinase sIgA of human milk is the third example of natural antibodies (Abs) with synthetic activity.
  31. ncbi Breast milk transmission of HIV-1. Laboratory and clinical studies
    P Van de Perre
    Centre Muraz, Organisation de Coordination et de Coopération pour la lutte contre les Grandes Endémies OCCGE, Bobo Dioulasso, Burkina Faso
    Ann N Y Acad Sci 918:122-7. 2000
    ..Transmission of HIV-1 by breastfeeding has to be taken into account in designing interventions to reduce/prevent mother-to-child transmission in developing countries...
  32. ncbi Human milk glycosaminoglycans inhibit HIV glycoprotein gp120 binding to its host cell CD4 receptor
    D S Newburg
    Shriver Center for Mental Retardation, Waltham, MA 02254
    J Nutr 125:419-24. 1995
    ..gp120, to its host cell receptor, CD4, is inhibited in a solid phase assay by a glycosaminoglycan of human milk; this binding is the essential first step in HIV infectivity...
  33. ncbi An exclusively human milk-based diet is associated with a lower rate of necrotizing enterocolitis than a diet of human milk and bovine milk-based products
    Sandra Sullivan
    Department of Pediatrics, University of Florida, Gainesville, FL, USA
    J Pediatr 156:562-7.e1. 2010
    To evaluate the health benefits of an exclusively human milk-based diet compared with a diet of both human milk and bovine milk-based products in extremely premature infants.
  34. ncbi Interleukin-10 and -12 in human milk at 3 stages of lactation: a longitudinal study
    H Levent Yilmaz
    Department of Pediatric Emergency Medicine, Medical Faculty of Cukurova University, Adana, Turkey
    Adv Ther 24:603-10. 2007
    ..A total of 87 human milk samples were collected from 29 healthy mothers during the colostrum (0-3 days), early milk (14-17 days), and ..
  35. pmc Isolation of bifidobacteria from breast milk and assessment of the bifidobacterial population by PCR-denaturing gradient gel electrophoresis and quantitative real-time PCR
    Rocio Martin
    Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands
    Appl Environ Microbiol 75:965-9. 2009
    ..dentium. Bifidobacterial DNA was detected by qRTi-PCR in the same 22 milk samples at a range between 40 and 10,000 16S rRNA gene copies per ml. In conclusion, human milk seems to be a source of living bifidobacteria for the infant gut.
  36. ncbi Predominate HIV1-specific IgG activity in various mucosal compartments of HIV1-infected individuals
    F X Lu
    California Regional Primate Research Center, University of California, Davis, Davis, California, 95616, USA
    Clin Immunol 97:59-68. 2000
    ....
  37. ncbi The nutritional iodine supply of Belgian neonates is still insufficient
    Roberta Ciardelli
    Department of Paediatrics, Saint Pierre Hospital, University of Brussels, Brussels, Belgium
    Eur J Pediatr 161:519-23. 2002
    ..Finally, the median urinary iodine increased from 60 micro g/l on day 5 to 150 micro g/l on day 30 in preterms bottle-fed with iodine-enriched formula-milk...
  38. ncbi Transfer of selected elements from food into human milk
    Olaf Wappelhorst
    International Graduate School of Zittau, Martk 23, D 02763 Zittau, Germany
    Nutrition 18:316-22. 2002
    ..We measured the transfer factors of antimony, cerium, chromium, cobalt, gallium, lanthanum, molybdenum, niobium, ruthenium, silver, thorium, titanium, and uranium from food to milk in nursing mothers...
  39. ncbi Polysaccharide kinase activity of human milk IgG antibodies
    N A Karataeva
    Institute of Chemical and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, 630090 Novosibirsk, Russia
    Biochemistry (Mosc) 71:1207-21. 2006
    A small fraction of human milk IgG antibodies is shown to possess polysaccharide kinase activity for the first time...
  40. ncbi Human milk polyunsaturated long-chain fatty acids and secretory immunoglobulin A antibodies and early childhood allergy
    K Duchen
    Department of Health and Environment, Linkoping University Hospital, Sweden
    Pediatr Allergy Immunol 11:29-39. 2000
    ..Besides the methodological problems, differences in the composition of human milk could explain these controversies...
  41. ncbi Human milk oligosaccharides are associated with protection against diarrhea in breast-fed infants
    Ardythe L Morrow
    Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Pediatr 145:297-303. 2004
    ..To determine the association between maternal milk levels of 2-linked fucosylated oligosaccharide and prevention of diarrhea as a result of Campylobacter, caliciviruses, and diarrhea of all causes in breast-fed infants...
  42. pmc Longitudinal analysis of human immunodeficiency virus type 1 RNA in breast milk and of its relationship to infant infection and maternal disease
    Christine M Rousseau
    Department of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue, Seattle, WA 98109 1024, USA
    J Infect Dis 187:741-7. 2003
    ..3-3.0; P<.001). These results indicate that the risk of infant infection from breast-feeding is influenced by breast-milk virus load, which is highest early after delivery...
  43. ncbi Isolation and characterization of human milk bile salt-activated lipase C-tail fragment
    C S Wang
    Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
    Biochemistry 34:10639-44. 1995
    ..positions and oligosaccharide characteristics in the proline-rich, mucin-like, C-terminal region (C-tail) of human milk bile salt-activated lipase (BAL) were studied in order to assess the possible physiological functions of this ..
  44. ncbi Fatty acid composition abnormalities in atopic disease: evidence explored and role in the disease process examined
    A Sala-Vila
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
    Clin Exp Allergy 38:1432-50. 2008
    ....
  45. pmc Breast-milk infectivity in human immunodeficiency virus type 1-infected mothers
    Barbra A Richardson
    Department of Biostatistics, University of Washington, Harborview Medical Center, Box 359909, 325 Ninth Avenue, Seattle, WA 98104 2499, USA
    J Infect Dis 187:736-40. 2003
    ..The probability of HIV-1 infection per liter of breast milk ingested by an infant is similar in magnitude to the probability of heterosexual transmission of HIV-1 per unprotected sex act in adults...
  46. pmc A critical review of methods for comparing estrogenic activity of endogenous and exogenous chemicals in human milk and infant formula
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, Alachua, Florida, USA
    Environ Health Perspect 111:1020-36. 2003
    The two primary sources of nutrition for infants are human milk and infant formula. Both contain an array of endogenous and exogenous chemicals that may act through many separate hormonal mechanisms...
  47. ncbi Antiinfective properties of human milk
    Gaetano Chirico
    Department of Neonatology and Neonatal Intensive Care, Spedali Civili, 25123 Brescia, Italy
    J Nutr 138:1801S-1806S. 2008
    ..occurring compensatory mechanisms, such as the introduction of protective and immunological components of human milk in the infant...
  48. ncbi Protection of the neonate by the innate immune system of developing gut and of human milk
    David S Newburg
    Pediatric Gastroenterology and Nutrition Unit, MassGeneral Hospital for Children and Harvard Medical School, Boston, Massachusetts, USA
    Pediatr Res 61:2-8. 2007
    ..Enteric neurons and lymphocytes provide paracrine and endocrine signaling. However, full protection requires human milk. Breast-feeding reduces enteric infection and may reduce chronic disease in later life...
  49. pmc Individual characteristics associated with PBDE levels in U.S. human milk samples
    Julie L Daniels
    Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, North Carolina 27599 7435, USA
    Environ Health Perspect 118:155-60. 2010
    ..Reported polybrominated diphenyl ether (PBDE) concentrations in human samples in the United States have been higher than in Europe and Asia. Little is known about factors that contribute to individual variability in body burden...
  50. ncbi FADS1 FADS2 gene variants modify the association between fish intake and the docosahexaenoic acid proportions in human milk
    Carolina Moltó-Puigmartí
    Department of Nutrition and Food Science, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain
    Am J Clin Nutr 91:1368-76. 2010
    ..Docosahexaenoic acid (DHA) can be supplied especially by dietary fish or fish oil and synthesized from alpha-linolenic acid through a pathway involving these desaturases...
  51. ncbi Free glutamine and glutamic acid increase in human milk through a three-month lactation period
    C Agostoni
    Department of Pediatrics, San Paolo Hospital, Milan, Italy
    J Pediatr Gastroenterol Nutr 31:508-12. 2000
    Previous short observational studies on the free amino acid (FAA) content of human milk have shown that glutamine and glutamic acid increase in the first 4 to 6 weeks of life.
  52. ncbi Breast-feeding and cognitive development: a meta-analysis
    J W Anderson
    Metabolic Research Group, Veterans Affairs Medical Center
    Am J Clin Nutr 70:525-35. 1999
    ....
  53. ncbi Trefoil factors in human milk
    Else Marie Vestergaard
    Department of Clinical Biochemistry, Aarhus University Hospital Skejby, Aarhus, Denmark
    Early Hum Dev 84:631-5. 2008
    We measured concentrations of the gastrointestinal protective peptides Trefoil factors in human milk. By the use of in-house ELISA we detected high amounts of TFF3, less TFF1 and virtually no TFF2 in human breast milk obtained from 46 ..
  54. ncbi Fucosylated human milk oligosaccharides vary between individuals and over the course of lactation
    P Chaturvedi
    Shriver Center for Mental Retardation, Waltham, MA 02452, USA
    Glycobiology 11:365-72. 2001
    Specific human milk oligosaccharides, especially fucosylated neutral oligosaccharides, protect infants against specific microbial pathogens...
  55. ncbi Exposure assessment of French women and their newborn to brominated flame retardants: determination of tri- to deca- polybromodiphenylethers (PBDE) in maternal adipose tissue, serum, breast milk and cord serum
    Jean Philippe Antignac
    LABoratoire d Etude des Résidus et Contaminants dans les Aliments, USC INRA 2013, Ecole Nationale Veterinaire de Nantes, Route de Gachet, BP 50707, 44307 Nantes Cedex 3, France
    Environ Pollut 157:164-73. 2009
    ..At this opposite, median levels of octa- to decaBDE in maternal and cord serum appeared significantly higher than the levels of tri- to heptaBDE in the same matrices, i.e. 8.85 and 12.34 versus 0.98 and 0.69 ng g(-1) l w, respectively...
  56. pmc Breast-feeding and Transmission of HIV-1
    Grace John-Stewart
    Department of Medicine, University of Washington, USA
    J Acquir Immune Defic Syndr 35:196-202. 2004
    ..Innate and acquired immune factors may act most effectively in combination to prevent primary HIV-1 infection by breast milk...
  57. ncbi Semiautomated high-throughput extraction and cleanup method for the measurement of polybrominated diphenyl ethers and polybrominated and polychlorinated biphenyls in breast milk
    Andreas Sjodin
    National Center for Environmental Health, Division of Laboratory Sciences, Organic Analytical Toxicology Branch, Centers for Disease Control and Prevention, 4770 Buford Hwy NE Mail Stop F 17, Atlanta, Georgia 30341, USA
    Anal Chem 76:4508-14. 2004
    ..Mean recoveries of the (13)C-labeled internal standards ranged from 60 to 89% for the eight PBDE congeners; 74 and 113% were recovered for BB-153 and CB-153, respectively...
  58. ncbi The immune system in human milk and the developing infant
    Armond S Goldman
    Department of Pediatrics, The University of Texas Medical Branch, Galveston, Texas 77555 0369, USA
    Breastfeed Med 2:195-204. 2007
    The concept of the immune system in human milk emerged in the 1970s from clinical and laboratory observations made between the late 18th through the mid-20th centuries...
  59. ncbi Human milk compounds inhibiting adhesion of mutans streptococci to host ligand-coated hydroxyapatite in vitro
    L Danielsson Niemi
    Department of Odontology Cariology, Umea University, Umea, Sweden
    Caries Res 43:171-8. 2009
    ..Following our recent finding that human milk may inhibit adhesion of Streptococcus mutans the aim of the present study was to identify compounds in human ..
  60. ncbi Human milk fatty acid composition from nine countries varies most in DHA
    Rebecca Yuhas
    Department of Nutrition Research, Wyeth Nutrition, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
    Lipids 41:851-8. 2006
    ..The results of this study demonstrate that the proportion of saturated and monounsaturated FA are relatively constant across a large number of countries, whereas the level of some of the PUFA, especially DHA, are highly variable...
  61. ncbi Advances in our understanding of the biology of human milk and its effects on the offspring
    Lene Schack-Nielsen
    Department of Human Nutrition, Faculty of Life Science, University of Copenhagen, DK 1958, Frederiksberg C, Denmark
    J Nutr 137:503S-510S. 2007
    ..Recent data have suggested that breast-feeding can program the insulin-like growth factor-I axis, as 3 studies found that breast-fed infants are taller as adults...
  62. pmc Role of human milk in extremely low birth weight infants' risk of necrotizing enterocolitis or death
    J Meinzen-Derr
    Division of Neonatology, Department of Pediatrics, Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    J Perinatol 29:57-62. 2009
    To determine the association between human milk (HM) intake and risk of necrotizing enterocolitis (NEC) or death among infants 401 to 1000 g birth weight.
  63. pmc Differential transcriptional response of Bifidobacterium longum to human milk, formula milk, and galactooligosaccharide
    Rina González
    Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, The Netherlands
    Appl Environ Microbiol 74:4686-94. 2008
    ..in breast milk and included putative genes for N-acetylglucosamine degradation and for metabolism of mucin and human milk oligosaccharides via the galactose/lacto-N-biose gene cluster...
  64. ncbi Innate immunity and human milk
    David S Newburg
    Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Charlestown, MA, USA
    J Nutr 135:1308-12. 2005
    ..Thus, the innate immune system of human milk is an important complement to the mucosal barrier of the developing gut...
  65. ncbi Human exposure to PBDEs: associations of PBDE body burdens with food consumption and house dust concentrations
    Nerissa Wu
    Department of Environmental Health Talbot 2E, Boston University School of Public Health, 715 Albany Street, Boston, Massachusetts 02118, USA
    Environ Sci Technol 41:1584-9. 2007
    ..Our results support the hypothesis that the indoor environment and diet both play prominent roles in adult human exposure to PBDEs...
  66. pmc Salivary secretory leukocyte protease inhibitor is associated with reduced transmission of human immunodeficiency virus type 1 through breast milk
    Carey Farquhar
    Departments of Medicine, Epidemiology, and Biostatistics, University of Washington, 325 Ninth Avenue, Seattle, WA 98104 2499, USA
    J Infect Dis 186:1173-6. 2002
    ..5; 95% confidence interval, 0.3-0.9; P=.03). These results suggest that SLPI plays an important role in reducing HIV-1 transmission through breast milk...
  67. ncbi Human milk proteins: an interactomics and updated functional overview
    Angelo D'Alessandro
    Department of Environmental Sciences, University of Tuscia, Largo dell Universita, snc, 01100 Viterbo, Italy
    J Proteome Res 9:3339-73. 2010
    ..and pathway and network analyses, we merged data from literature dealing with protein-oriented studies on human milk. A total of 285 entries defined a nonredundant list upon comparison with the Ingenuity Knowledge Base from the ..
  68. ncbi Human milk proteins: key components for the biological activity of human milk
    Bo Lonnerdal
    Department of Nutrition and Program of International Nutrition, University of California, Davis, CA 95616, USA
    Adv Exp Med Biol 554:11-25. 2004
    b>Human milk contains a wide array of proteins that provide biologic activities ranging from antimicrobial effects to immunostimulatory functions...
  69. ncbi Evaluation of xenobiotics in human milk and ingestion by the newborn--an epidemiological survey in Lombardy (Northern Italy)
    Giovanna Turconi
    Department of Applied Health and Psycho behavioural Sciences, Section of Human Nutrition Faculty of Medicine, University of Pavia, via Bassi 21, 27100, Italy
    Eur J Nutr 43:191-7. 2004
    Many human milk benefits have been well documented; nevertheless the newborn potential risk to the xenobiotic exposition may be relevant and it requires a biological monitoring in general prevention...
  70. ncbi Physiological aspects of human milk lipids
    B Koletzko
    Department of Pediatrics, Kinderklinik and Kinderpoliklinik, Dr von Haunersches Kinderspitel, Ludwig Maximilians University of Munich, Lindwurmstr 4, D 80337, Munich, Germany
    Early Hum Dev 65:S3-S18. 2001
    b>Human milk from healthy and well-nourished mothers is the preferred form of feeding for all healthy newborn infants. The nutrient supply with human milk supports normal growth and development of the infant...
  71. pmc Structural basis for the interaction between human milk oligosaccharides and the bacterial lectin PA-IIL of Pseudomonas aeruginosa
    Stephanie Perret
    Centre de Recherches sur les Macromolecules Vegetales, CNRS, Universite Joseph Fourier, BP53, 38041 Grenoble Cedex 09, France
    Biochem J 389:325-32. 2005
    ..to the protection by breast-feeding of the newborn against enteric diseases is related to the ability of human milk oligosaccharides to prevent the attachment of pathogenic bacteria to the duodenual epithelium...
  72. ncbi Structural analysis of underivatized neutral human milk oligosaccharides in the negative ion mode by nano-electrospray MS(n) (part 1: methodology)
    Anja Pfenninger
    Institute of Pharmaceutical Chemistry, J W Goethe University, Frankfurt Main, Germany
    J Am Soc Mass Spectrom 13:1331-40. 2002
    Underivatized neutral oligosaccharides from human milk were analyzed by nano-electrospray ionization (ESI) using a quadrupole ion trap mass spectrometer (QIT-MS) in the negative-ion mode...
  73. ncbi Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children's IQ at 4 years of age
    Ingrid B Helland
    Institute for Nutrition Research, University of Oslo, Oslo, Norway Peter Möller, avd Orkla, ASA, Oslo, Norway
    Pediatrics 111:e39-44. 2003
    ....
  74. ncbi Metabolism of phthalates in humans
    Hanne Frederiksen
    Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Mol Nutr Food Res 51:899-911. 2007
    ..This differential distribution is of special concern as, in particular, the hydrophobic phthalates and their metabolites are shown to have adverse effects following in utero and lactational exposures in animal studies...
  75. pmc Bifidobacterium bifidum lacto-N-biosidase, a critical enzyme for the degradation of human milk oligosaccharides with a type 1 structure
    Jun Wada
    Graduate School of Biostudies, Kyoto University, Kitashirakawa, Sakyo ku, Kyoto 606 8502, Japan
    Appl Environ Microbiol 74:3996-4004. 2008
    ..type 1 chain) from lacto-N-tetraose (Galbeta1,3GlcNAcbeta1,3Galbeta1,4Glc), which is a major component of human milk oligosaccharides, and subsequently isolated the gene from Bifidobacterium bifidum JCM1254...
  76. ncbi Comparing water, bovine milk, and indoor residual spraying as possible sources of DDT and pyrethroid residues in breast milk
    Barbara Sereda
    Agricultural Research Council, Plant Protection Research Institute, Pretoria, South Africa
    J Toxicol Environ Health A 72:842-51. 2009
    ....
  77. ncbi Human milk: maternal dietary lipids and infant development
    Sheila M Innis
    Nutrition Research Program, Child and Family Research Institute, University of British Columbia, 950 West 28th Avenue, Vancouver, BC V5Z 4H4, Canada
    Proc Nutr Soc 66:397-404. 2007
    b>Human milk provides all the dietary essential fatty acids, linoleic acid (LA; 18:2n-6) and alpha-linolenic acid (18:3n-3), as well as their longer-chain more-unsaturated metabolites, including arachidonic acid (20:4n-6) and DHA (22:6n-3) ..
  78. ncbi A strategy for annotating the human milk glycome
    Milady R Ninonuevo
    Department of Chemistry and Biochemistry School of Medicine, University of California, Davis, California 95616, USA
    J Agric Food Chem 54:7471-80. 2006
    Oligosaccharides in human milk represent a group of bioactive molecules that have evolved to be an abundant and diverse component of human milk, even though they have no direct nutritive value to the infant...
  79. ncbi Perfluorinated compounds in human milk from Massachusetts, U.S.A
    Lin Tao
    Wadsworth Center, New York State Department of Health, Albany, New York, USA
    Environ Sci Technol 42:3096-101. 2008
    ..8 pg/mL, respectively. Comparison of the ratio of PFOS to PFOA in human milk with the ratios published for human serum from the U.S...
  80. ncbi Flash-heat inactivation of HIV-1 in human milk: a potential method to reduce postnatal transmission in developing countries
    Kiersten Israel-Ballard
    Division of Epidemiology, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    J Acquir Immune Defic Syndr 45:318-23. 2007
    ..The World Health Organization recommends heat-treated breast milk as an infant-feeding alternative. We investigated the ability of a simple method, flash-heat, to inactivate HIV in breast milk from HIV-positive mothers...
  81. pmc Insulin in human milk: postpartum changes and effect of gestational age
    N Shehadeh
    Department of Neonatology, Meyer Children s Hospital, Rambam Medical Center, Bat Galim, Haifa 31096, Israel
    Arch Dis Child Fetal Neonatal Ed 88:F214-6. 2003
    To determine if human milk insulin (HMI) concentrations are affected by gestational age and postnatal age.
  82. ncbi Determination of polycyclic aromatic hydrocarbons (PAHs) and total fats in human milk
    Massimo Del Bubba
    Department of Chemistry University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence Italy
    Ann Chim 95:629-41. 2005
    ..method was developed for the simultaneous extraction of PAHs and total fats and their determination in the human milk. The method involved a liquid-liquid extraction of PAHs and fats, followed by the gravimetric determination of ..
  83. ncbi Organochlorine pesticide residues in human milk of a Hmong hill tribe living in Northern Thailand
    W Stuetz
    Institute of Biological Chemistry and Nutrition, University of Hohenheim, Stuttgart, Germany
    Sci Total Environ 273:53-60. 2001
    ....
  84. ncbi [Polybrominated diphenyl ether flame retardants in foodstuffs and human milk]
    Kazuhiko Akutsu
    Osaka Prefectural Institute of Public Health 1 3 69, Nakamichi, Higashinari ku, Osaka 537 0025, Japan
    Shokuhin Eiseigaku Zasshi 45:175-83. 2004
    ..In this review, published information on the toxicology of PBDEs, levels in foodstuffs and human milk, and analytical methods has been compiled.
  85. pmc Development of an annotated library of neutral human milk oligosaccharides
    Shuai Wu
    Department of Chemistry, University of California, Davis, California 95616, USA
    J Proteome Res 9:4138-51. 2010
    b>Human milk oligosaccharides (HMOs) perform a number of functions including serving as prebiotics to stimulate the growth of beneficial intestinal bacteria, as receptor analogues to inhibit binding of pathogens, and as substances that ..
  86. ncbi Exposure patterns of UV filters, fragrances, parabens, phthalates, organochlor pesticides, PBDEs, and PCBs in human milk: correlation of UV filters with use of cosmetics
    Margret Schlumpf
    GREEN Tox and Institute of Anatomy, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland
    Chemosphere 81:1171-83. 2010
    ..We present data on chemicals in human milk of a cohort study (2004, 2005, 2006) of 54 mother/child pairs, where for the first time, cosmetic UV filters, ..
  87. ncbi Analysis of high-molecular-weight oligosaccharides from human milk by liquid chromatography and MALDI-MS
    B Finke
    Milupa Research, Milupa GmbH and Company KG, Friedrichsdorf, Germany
    Anal Chem 71:3755-62. 1999
    Pooled human milk oligosaccharides were fractionated by anion-exchange chromatography on AG 1-X2 and by an improved gel filtration procedure that allowed the separation of large oligosaccharides on Toyopearl HW 40 (S) and Bio-Gel P-6 ..
  88. ncbi The influence of sardine consumption on the omega-3 fatty acid content of mature human milk
    Rose V Patin
    Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil
    J Pediatr (Rio J) 82:63-9. 2006
    ..The purpose of this study was to investigate what effect the ingestion of sardines, rich in omega-3 series polyunsaturated fatty acids, has on the composition of breastmilk...
  89. ncbi Timing of breast milk HIV-1 transmission: a meta-analysis
    G C John
    Departments of Medicine, Epidemiology, and Biostatistics, University of Washington, Seattle, Washington 98195, USA
    East Afr Med J 78:75-9. 2001
    ..While recently published studies showing some effectiveness of antiretrovirals early during the breast feeding period are encouraging, prevention of breast milk HIV-1 transmission needs to remain a high research priority...
  90. ncbi Folate contents in human milk and casein-based and soya-based formulas, and folate status in Korean infants
    Young Hee Han
    Department of Food and Nutrition, Chungbuk National University, Cheongju, Korea
    Br J Nutr 101:1769-74. 2009
    We assessed folate nutritional status from birth to 12 months in fifty-one infants who were fed human milk (HM; n 20), casein-based formula (CBF; n 12) or soya-based formula (SBF; n 19)...
  91. ncbi Reflections on the American Academy of Pediatrics' 2005 policy statement on "Breastfeeding and the use of human milk"
    Ulfat Shaikh
    J Hum Lact 22:108-10. 2006
  92. ncbi Human milk oligosaccharides inhibit the adhesion to Caco-2 cells of diarrheal pathogens: Escherichia coli, Vibrio cholerae, and Salmonella fyris
    Giovanni V Coppa
    Institute of Maternal Infantile Sciences, Polytechnic University of Marche, Italy
    Pediatr Res 59:377-82. 2006
    ..ones, have a lower incidence of acute gastroenteritis due to the presence of several antiinfective factors in human milk. The aim of this work is to study the ability of human milk oligosaccharides to prevent infections related to ..
  93. ncbi A low-molecular-weight factor in human milk whey promotes iron uptake by Caco-2 cells
    Paz Etcheverry
    Department of Food Science, Cornell University, Ithaca, NY 14853, USA
    J Nutr 134:93-8. 2004
    The iron bioavailability of human milk (HM) is substantially greater than that of cow's milk (CM), but the factor responsible for this high bioavailability is unknown...
  94. ncbi The effect of calcium salts, ascorbic acid and peptic pH on calcium, zinc and iron bioavailabilities from fortified human milk using an in vitro digestion/Caco-2 cell model
    Paz Etcheverry
    Department of Food Science, Stocking Hall, Cornell University, Ithaca, NY 14853, USA
    Int J Vitam Nutr Res 75:171-8. 2005
    The calcium, zinc, and iron bioavailabilities of human milk with commercial and noncommercial human milk fortifiers (HMFs) were evaluated under a variety of conditions: peptic digestion at pH 2 and pH 4, supplementation of ascorbic acid, ..
  95. ncbi Honey and royal jelly, like human milk, abrogate lectin-dependent infection-preceding Pseudomonas aeruginosa adhesion
    Batia Lerrer
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    ISME J 1:149-55. 2007
    ..Such compounds were found in human milk (HM) and avian egg whites...
  96. ncbi Conjugated linoleic acid determination in human milk by fast-gas chromatography
    Carolina Moltó-Puigmartí
    Department of Nutrition and Food Science, Food Technology Reference Centre, Faculty of Pharmacy, University of Barcelona, Av Joan XXIII s n E 08028 Barcelona, Spain
    Anal Chim Acta 602:122-30. 2007
    ..S.D.) of repeatability and reproducibility ranging between 0.10 and 8.71%. The application of this method to human and rat milk samples showed that it was a rapid, simple and reliable method for the analysis of biological samples...
  97. ncbi DDT, DDE and DDD in human milk from South Africa
    Jonathan Okechukwu Okonkwo
    Tshwane University of Technology, Pretoria, South Africa
    Bull Environ Contam Toxicol 81:348-54. 2008
    ..The SigmaDDT was found to decrease with increasing age of the mothers. The observed high levels of DDE compared to DDT indicated chronic exposure of the mothers to DDT, which is metabolised to DDE and retained in the body...
  98. ncbi Fatty acid composition of human milk in atopic Danish mothers
    Lotte Lauritzen
    Department of Human Nutrition, Center for Advanced Food Studies, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Am J Clin Nutr 84:190-6. 2006
    ..Atopic dermatitis has been related to a disturbed metabolism of polyunsaturated fatty acids (PUFAs)...
  99. ncbi Human milk oligosaccharides reduce platelet-neutrophil complex formation leading to a decrease in neutrophil beta 2 integrin expression
    Lars Bode
    Institute of Nutritional Science, Justus Liebig University Giessen, Germany
    J Leukoc Biol 76:820-6. 2004
    b>Human milk is thought by many authorities to be preferable to formula as a source of nutrients for infants. Some of the benefits may stem from its high concentration of unbound oligosaccharides (5-10 g/L)...
  100. ncbi Activity against Listeria monocytogenes of human milk during lactation. A preliminary study
    Ivan Lopez-Exposito
    Instituto de Fermentaciones Industriales CSIC C Juan de la Cierva, 3, 28006 Madrid, Spain
    J Dairy Res 75:24-9. 2008
    b>Human milk samples from three healthy donors were investigated in order to evaluate the antibacterial activity during lactation against Escherichia coli ATCC 25922 and Listeria monocytogenes...
  101. ncbi Nutrient composition of human milk
    M F Picciano
    Department of Nutrition, Pennsylvania State University, University Park, Pennsylvania, USA
    Pediatr Clin North Am 48:53-67. 2001
    ..Investigations provide evidence that human milk possesses many unique characteristics and that maternal and environmental influences are stronger than ..

Research Grants64

  1. Metabolic Adapation and Control of Lactation in Humans
    Morey W Haymond; Fiscal Year: 2010
    ..S. and Western Europe. Human milk is universally accepted as the ideal food for infants and breastfeeding has real and potential benefits for the ..
  2. DHA attenuates Inflammatory Responses Through Altering RAGE Signaling
    LYNETTE KAY ROGERS; Fiscal Year: 2013
    ..accretion and are often not provided "pre-formed" DHA in parenteral nutrition or receive low levels in milk from human milk banks...
  3. Detection of engineered nanomaterials in drinking water, food, commercial product
    Paul K Westerhoff; Fiscal Year: 2010
    ..food, consumer products and biological fluids (including whole blood, blood plasma, blood serum, urine and human milk). Our team has extensive experience in the analysis of manmade pollutants in these matrices...
  4. Investigation on Oligosaccharides as Antimicrobial and Prebiotics
    Peng George Wang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human milk oligosaccharides (HMOs) have been thought to play a role in the development of specific intestinal flora in breast-fed infants for many years...
  5. Lactoferrin for Immunomodulation of Systemic Inflammatory Response Syndrome
    Marian L Kruzel; Fiscal Year: 2011
    ..Focus will be made on utility of rhLF, with dose range comparisons made to commercially available human milk- and neutrophil-derived lactoferrins...
  6. Oligosaccharide moieties of human milk glycans that inhibit pathogens
    David S Newburg; Fiscal Year: 2013
    ..that the reduced incidence of enteric diseases in breastfeeding infants is due, in part, to protection by human milk glycans...
  7. Activation of Host-Probiotic Communication by Prebiotic Milk Oligosaccharides
    Helen E Raybould; Fiscal Year: 2012
    ..Work from the UC Davis Milk Bioactives Program has shown that human milk oligosaccharides are utilized by select bifidobacterial strains and demonstrated that small mass oligosaccharide ..
  8. Milk oligosaccharides, bifidobacteria and intestinal epithelium.
    Maciej Chichlowski; Fiscal Year: 2011
    ..are often enriched in the infant gastrointestinal tract. It has been proposed that human milk oligosaccharides (HMO), a major component of breast milk, are responsible for this enrichment...
  9. MALDI-TOF/TOF MS TO SUPPORT BIOMEDICAL RESEARCH
    Catherine E Costello; Fiscal Year: 2012
    ..Cell Disease, Traumatic Brain Injury, infectious diseases and characterization of protective components in human milk. Ten Major and six Minor research projects are proposed...
  10. Human Milk Factor Protection in Neonatal Necrotizing Enterocolitis
    Sheng Ru Shiou; Fiscal Year: 2012
    ..Means of preventing this disease or treating it in its early stages may provide clinical benefit. Human milk has been shown to be protective against NEC in clinical studies...
  11. Early Infant Feeding and Epigenetic Modification in Tumor Suppressor Genes
    Anne Merewood; Fiscal Year: 2010
    ..b>Human milk is the optimal and evolutionarily designed source of human infant nutrition;the American Academy of Pediatrics ..
  12. The effect of a protein-lipid complex from human milk against pneumococcal otitis
    Emily Clementi; Fiscal Year: 2013
    ..Previous work has identified a protein-lipid complex from human milk (HAMLET) that effectively kills S...
  13. Prevention of Overfeeding During Infancy
    Kathryn G Dewey; Fiscal Year: 2010
    ..The other arm of the study will be conducted with infants who are fed human milk both at the breast and with a bottle...
  14. The association between preterm milk immunobiology and infant health
    MAUREEN EDITH GROER; Fiscal Year: 2013
    ..b>Human milk may play a moderating role in the multiple risks these vulnerable infants face, yet the total volume of human ..
  15. Accelerating Adoption of Comparative Effectiveness Research in Premature Infants
    Phillip Brian Smith; Fiscal Year: 2010
    ..data regarding feeding and prescribing practices coupled with targeted educational interventions will increase the proportion of preterm infants exposed to human milk feedings and decrease the proportion exposed to unproven medications.
  16. Oral Transmission of HIV through Breastfeeding
    Louise Kuhn; Fiscal Year: 2013
    ..We hypothesize that human milk oligosaccharides (HMO), soluble toll-like receptors (sTLR) and other innate immune factors may play a role in ..
  17. The Role of Human Milk in Infant Nutrition and Health
    Ardythe L Morrow; Fiscal Year: 2013
    ..by applicant): In this revised application, we seek competitive renewal of our program project, "The Role of Human Milk in Infant Nutrition and Health," which is now entering its 31st year...
  18. Necrotizing Enterocolitis: Prevention and Prediction
    MARK ALAN UNDERWOOD; Fiscal Year: 2012
    ..exciting preliminary data: a clinical trial of two probiotic products in premature infants, evidence that human milk oligosaccharides selectively stimulate growth of specific bifidobacteria, and a novel potential biomarker of ..
  19. Mechanisms by which Human Milk Oligosaccharides Protect Against Rotavirus
    SHARON MARIE DONOVAN; Fiscal Year: 2012
    b>Human milk contains a remarkable content and structural diversity of oligosaccharides (HMO) that act as a component of the innate immunity by preventing attachment of pathogens to the intestinal lining and by promoting colonization by a ..
  20. Bioactivation of PBDEs by Human Cytochrome P-450
    James R Olson; Fiscal Year: 2013
    ..Aim 2 will identify and quantify OH-PBDEs in human milk and serum, and assess the potential impact of CYP2B6 genotype on the body burden of PBDEs which was previously ..
  21. EFFECT OF COLOSTRUM ON GUT MATURATION AND HOST DEFENSE
    W Allan Walker; Fiscal Year: 2013
    ..Accordingly, our working hypothesis for this renewal reapplication is that human milk provides a protective link from mother to newborn in the extrauterine environment by actively stimulating the ..
  22. Synthesis and Screening of Bioactive Glycolipids
    Jacquelyn Gervay-Hague; Fiscal Year: 2012
    ..in this application will support collaborative efforts focused on the identification of glycan motifs from human milk and different organism types...
  23. Structures, Functions, &Genetic Diversity of Oligosaccharides in Milk
    Carlito B Lebrilla; Fiscal Year: 2013
    ..b>Human milk, on the other hand, is an attractive source of oligosaccharides precisely because human milk produces a unique ..
  24. Intestinal and Milk Glycan Expression in Restriction of Neonatal Infection
    MARY KOLB ESTES; Fiscal Year: 2013
    ..studies to test the hypothesis that the complex interactions between glycan expression, neonatal development and human milk oligosaccharides affect neonatal enteric infections...
  25. Novel Surfaces for Enriching Epithelial Cells: A Breastmilk Model
    Maria M Santore; Fiscal Year: 2013
    ..risk detection method for breast cancer, based on changes in the DNA of breast epithelial cells found in human milk, requires purification and concentration of these cells, and exclusion of lymphocytes, fats, and proteins that ..
  26. Epigenetic Interaction of MECP2 and Organic Pollutants in Neurodevelopment
    Janine LaSalle; Fiscal Year: 2009
    ..biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in the environment and their detection in human milk has prompted concern about in utero and early infant exposure to these compounds...
  27. Hyaluronan regulation of microbial host defense of the intestine
    Carol A De La Motte; Fiscal Year: 2013
    ..We have recently identified a new glycan, hyaluronan (HA), in human milk, which occurs at the highest concentration during the early stage of human lactation and decreases gradually ..
  28. Mechanism of Activation of Probiotic Bifidobacteria by Prebiotic Milk Glycans
    Carolyn Slupsky; Fiscal Year: 2013
    ..Work from the UC Davis Milk Bioactives Program has shown that human milk oligosaccharides are utilized by select infant-borne bifidobacterial strains that demonstrated unique ..
  29. Fusing Glycobiology and Nutritional Sciences to Prevent Necrotizing Enterocolitis
    Lars Bode; Fiscal Year: 2009
    ..We hypothesize that oligosaccharides present in human milk but not in infant formula contribute to the protective effects in breast-fed infants by inhibiting P-selectin ..
  30. Oligosaccharides as antimicrobials and prebiotics
    Xi Chen; Fiscal Year: 2013
    ..They are also the major components of human milk oligosaccharides. These carbohydrates are often terminated with a galactose, a fucose, or a sialic acid residue...
  31. Role of Environmental Chemicals on Lactation Outcomes
    SHEELA RATH GERAGHTY; Fiscal Year: 2010
    ..including the Cincinnati Children's Environmental Health Center and the Cincinnati Children's Research Human Milk Bank...
  32. High-yield production of GDP-fucose for fucosylation of molecules
    Leila Aminova; Fiscal Year: 2013
    ..and optimize the production of GDP-fucose and demonstrate its utility by testing the production of several human milk from starting materials that are readily available to us...
  33. Clinical Epidemiologic and Biologic Studies of Donor Human Milk and Breastfeeding
    TARAH TRINITY COLAIZY; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Breastfeeding is an important health-promoting behavior. Human milk is the ideal diet for all infants, optimizes intellect, and provides protection against infectious and atopic diseases in childhood ..
  34. NICHD Cooperative Multicenter Neonatal Research Network
    KURT R SCHIBLER; Fiscal Year: 2013
    ..Alan Jobe;and 3) Human Milk Sciences - investigating the importance of bioactive substance in milk led by Dr. Ardythe Morrow...
  35. TEST OF TAURINE AS AN ESSENTIAL NUTRIENT
    John Sturman; Fiscal Year: 1993
    ..low-taurine commercial infant formulas have low plasma and urine taurine concentrations compared to infants fed human milk, which is very rich in taurine...
  36. DIOXINS AND HYPOTHALAMIC APPETITE NEUROPEPTIDES
    GEORGE GREELEY; Fiscal Year: 2000
    ..Their abundance in human milk and potent neurodevelopmental toxicity, including growth retardation, in children exposed perinatally to ..
  37. NOVEL EVALUATION OF LACTATION PERFORMANCE
    Cutberto Garza; Fiscal Year: 1991
    Although human milk is acknowledged to be the ideal food for the infant, little information is available concerning the infant's use of specific functional components or the dynamics of milk production by the mother...
  38. Recombinant Lactoferrin and Necrotizing Enterocolitis
    Karel Petrak; Fiscal Year: 2004
    ..that all VLBW infants would benefit from receiving rhLF for at least 4 weeks after birth or until full human milk feedings are established. Biotechnology has made rhLF available for drug development...
  39. MARKERS OF HUMAN INFECTION WITH BOVINE LEUKEMIA VIRUS
    GERTRUDE BUEHRING; Fiscal Year: 2007
    ..This virus is transmitted from mother to offspring via milk. Since humans drink more cows' milk than human milk, a bovine virus might be a cause of human breast cancer...
  40. Breast milk: Physiology, Biochemistry and Outcomes
    Ardythe Morrow; Fiscal Year: 2006
    ..is to request NIH sponsorship of the September 2006 conference of the International Society for Research in Human Milk and Lactation...
  41. OMEGA-3 FATTY ACIDS IN NORMAL VISUAL DEVELOPMENT
    Eileen Birch; Fiscal Year: 2003
    ..The argument that LCPs are present in human milk as a basis for their inclusion in infant formula is compelling but limited by the lack of data on the short-term ..
  42. ISOLATION OF OLIGOSACCHARIDES--SUGAR-BINDING PROTEINS
    David Smith; Fiscal Year: 1990
    ..antigens, defined by monoclonal antibodies against human tumors cells, are also found as free sugars in human milk. Monospecific rabbit antisera prepared against purified human milk oligosaccharides have been used to detect and ..
  43. MUCOSAL PROTECTIVE FACTORS IN HUMAN MILK
    Radhakrishna Rao; Fiscal Year: 2003
    ..Such a beneficial effect was not observed by feeding infant formula. We recently demonstrated that human milk contains protective factors that protect the intestinal epithelial barrier function from oxidative-stress ..
  44. BIOTIN REQUIREMENTS OF INFANTS
    Donald Mock; Fiscal Year: 1992
    ..biotin balance in normal, formula-fed infants fed formula with biotin supplementation at levels similar to human milk and commercial infant formula...
  45. FEEDING STRATEGIES FOR LOW BIRTH WEIGHT INFANTS
    RICHARD SCHANLER; Fiscal Year: 2000
    ..in both a randomized trial of feeding premature infants FMM supplemented either with fortified pasteurized donor human milk or preterm formula and in a non-randomized comparison of FMM and preterm formula; 2) To determine the ..
  46. BETA-CAROTENE IN HUMAN MILK: QUANTITATION AND TRANSPORT
    Louise Canfield; Fiscal Year: 1993
    ..As detailed quantitative information about retinoids and carotenoids in human milk is lacking, our objective in Phase I is to identify the major carotenoids and retinoids in pooled samples of ..
  47. X RAY STRUCTURAL STUDIES OF LACTOFERRIN
    Edward Baker; Fiscal Year: 2000
    DESCRIPTION (Adapted from applicant's abstract): Lactoferrin is a prominent iron-binding protein from human milk, other secretions, and leukocytes and possesses a wide variety of established or proposed biological activities...
  48. Formula with antimicrobials to decrease infant mortality
    Koteswara Chintalacharuvu; Fiscal Year: 2006
    ..Secretory IgA, lactoferrin and lysozyme not present in formula milk[unreadable] but present in human milk protect against infections...
  49. ROLE OF DIETARY N-3 FATTY ACIDS IN PREMATURE INFANTS
    Susan Carlson; Fiscal Year: 1992
    ..Nonphysiological declines in RBC DHA occur following early delivery unless DHA is fed (human milk, fish oil)...
  50. HIGH RESOLUTION DNASE I HYPERSENSITIVE SITE MAPPING IN MAMMARY GLAND DEVELOPMENT
    Monique Rijnkels; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Human milk has been shown to provide significant health benefits to infants...
  51. NUTRITION AND METABOLISM--ABETALIPOPROTEINEMIA
    D Illingworth; Fiscal Year: 1991
    ..b>Human milk triglycerides are believed to be derived from the fatty acids present in triglyceride-rich lipoproteins and ..
  52. BACTERICIDAL ACTIVITY OF LACTOFERRIN ON ORAL FLORA
    Roland Arnold; Fiscal Year: 1993
    ..Specifically, the distribution and quantity of IgA-LF complex in human milk and saliva will be determined using ELISA procedures specific for this complex...
  53. BREASTFEEDING SERVICES FOR LBW INFANTS-OUTCOMES AND COST
    Linda Brown; Fiscal Year: 1999
    DESCRIPTION: (Adapted from applicant abstract) Human milk affords specific health benefits for low birth weight (LBW < 2500g) infants...
  54. HUMAN MAMMARY CELL GROWTH AND FUNCTION IN DEFINED MEDIA
    RICHARD HAM; Fiscal Year: 1990
    ..tools and needed for this research including the use of cloned cDNA and antisense RNA probes to analyze for human milk protein gene expression at the mRNA level, and antibodies to human milk proteins...
  55. VITAMIN D REQUIREMENT OF INFANTS
    Bruce Hollis; Fiscal Year: 1990
    ..D dietary regimens; 3) examine the effects of extended phototherapy on the antirachitic sterol content of human milk and how this phototherapy of the mother affects the mineral homeostasis of the nursing infant; 4) determine the ..
  56. Active Bottle for Preterm Infant Oral Feeding
    JAMES GOLDIE; Fiscal Year: 2006
    ..feeding tube, until they are capable of oral feeding by means of sucking and swallowing and can digest human milk or formula (Schanler & Lau)...
  57. RESPIRATORY MORBIDITY IN VERY LOW BIRTH WEIGHT INFANTS
    Michael Malloy; Fiscal Year: 1993
    ..c) whether infants discharged on supplemental oxygen have better growth and less morbidity; d) whether feeding human milk affects further respiratory morbidity and mortality...
  58. TRACE-ELEMENT EXPOSURE FROM HUMAN MILK AND FORMULA
    Steven Morris; Fiscal Year: 1980
    ..neutron activation analysis - to determine selected element concentrations in cow's milk, infant formula, and human milk; and (2) to compare these element concentrations in pooled samples of cow's milk and infant formula to ..
  59. MONITORING HUMAN EXPOSURE TO AFLATOXINS IN THE GAMBIA
    John Groopman; Fiscal Year: 1991
    ..with biological markers, such as excreted AFB-DNA adducts, oxidative metabolites in urine, aflatoxin Ml in human milk and covalently bound aflatoxin to serum albumin, to determine which of these markers have utility for non-..
  60. PATHOPHYSIOLOGY OF THE LACTOFERRINS
    PHILIP FURMANSKI; Fiscal Year: 1999
    DESCRIPTION: (adapted from the investigator's abstract) Lactoferrin (Lf) is the most avid Fe-binding protein in human milk and other epithelial secretions and is the major constituent of the specific granules of neutrophils...
  61. Active Bottle for Preterm Infant Oral Feeding
    JAMES GOLDIE; Fiscal Year: 2004
    ..feeding tube, until they are capable of oral feeding by means of sucking and swallowing and can digest human milk or formula (Schanler & Lau)...
  62. SIGNIFICANCE OF FOLATE-BINDING PROTEINS IN HUMAN MILK
    ASOK ANTONY; Fiscal Year: 1990
    This proposal will focus on two major aspects of the particulate and soluble folate binding proteins of human milk to identify (1) the factors involved in determining their quantitative and qualitative content in milk, and (2) the ..
  63. NOVEL WATER ISOTOPE DETERMINATION BY MASS SPECTROMETRY
    JAMES BRENNA; Fiscal Year: 1991
    ..water turnover rates, total energy expenditure (by the doubly labeled water method), and maternal-to-infant human milk transfer, require dosing of individuals with stable isotopically labeled water with subsequent high precision ..
  64. Role of virulence heterogeneity in acute and persistent EPEC diarrhea
    THERESA OCHOA; Fiscal Year: 2009
    Dr. Ochoa is a pediatric infectious diseases specialist studying the effect of human milk protective factors on enteropathogens...