nanotubes

Summary

Summary: Nanometer-sized tubes composed of various substances including carbon (CARBON NANOTUBES), boron nitride, or nickel vanadate.

Top Publications

  1. pmc In vitro self-assembly of tailorable nanotubes from a simple protein building block
    Edward R Ballister
    Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 105:3733-8. 2008
  2. pmc Stem cell fate dictated solely by altered nanotube dimension
    Seunghan Oh
    Department of Materials Science and Engineering, University California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 106:2130-5. 2009
  3. ncbi Functional connectivity between immune cells mediated by tunneling nanotubules
    Simon C Watkins
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Immunity 23:309-18. 2005
  4. doi Antibacterial nano-structured titania coating incorporated with silver nanoparticles
    Lingzhou Zhao
    School of Stomatology, The Fourth Military Medical University, No 145 West ChangLe Road, Xi an 710032, China
    Biomaterials 32:5706-16. 2011
  5. ncbi Nanowire dye-sensitized solar cells
    Matt Law
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    Nat Mater 4:455-9. 2005
  6. pmc Membrane nanotubes facilitate long-distance interactions between natural killer cells and target cells
    Anne Chauveau
    Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, United Kingdom
    Proc Natl Acad Sci U S A 107:5545-50. 2010
  7. pmc Tunneling-nanotube development in astrocytes depends on p53 activation
    Y Wang
    Laboratory of Neurobiology and State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing, China
    Cell Death Differ 18:732-42. 2011
  8. doi Scalable fabrication of silicon nanotubes and their application to energy storage
    Jung Keun Yoo
    Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology KAIST, 291 Daehak ro, Yuseong Gu, Daejeon 305 701, Republic of Korea
    Adv Mater 24:5452-6. 2012
  9. doi TiO2 nanotubes for bone regeneration
    Karla S Brammer
    Materials Science and Engineering, University of California, San Diego, La Jolla, CA 92093 0411, USA
    Trends Biotechnol 30:315-22. 2012
  10. ncbi Tunneling nanotubes: a new route for the exchange of components between animal cells
    Hans Hermann Gerdes
    Department of Biomedicine, University of Bergen, Jonas Lies vei 91, Bergen 5009, Norway
    FEBS Lett 581:2194-201. 2007

Research Grants

Detail Information

Publications425 found, 100 shown here

  1. pmc In vitro self-assembly of tailorable nanotubes from a simple protein building block
    Edward R Ballister
    Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 105:3733-8. 2008
    We demonstrate a method for generating discretely structured protein nanotubes from the simple ring-shaped building block, homohexameric Hcp1 from Pseudomonas aeruginosa...
  2. pmc Stem cell fate dictated solely by altered nanotube dimension
    Seunghan Oh
    Department of Materials Science and Engineering, University California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 106:2130-5. 2009
    ..Small (approximately 30-nm diameter) nanotubes promoted adhesion without noticeable differentiation, whereas larger (approximately 70- to 100-nm diameter) ..
  3. ncbi Functional connectivity between immune cells mediated by tunneling nanotubules
    Simon C Watkins
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Immunity 23:309-18. 2005
    ..These results demonstrate that nonneuronal cells can transmit signals to distant cells through a physically connected network...
  4. doi Antibacterial nano-structured titania coating incorporated with silver nanoparticles
    Lingzhou Zhao
    School of Stomatology, The Fourth Military Medical University, No 145 West ChangLe Road, Xi an 710032, China
    Biomaterials 32:5706-16. 2011
    ..In this study, titania nanotubes (TiO(2)-NTs) incorporated with silver (Ag) nanoparticles are fabricated on Ti implants to achieve this purpose...
  5. ncbi Nanowire dye-sensitized solar cells
    Matt Law
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    Nat Mater 4:455-9. 2005
    ..5% is demonstrated, limited primarily by the surface area of the nanowire array...
  6. pmc Membrane nanotubes facilitate long-distance interactions between natural killer cells and target cells
    Anne Chauveau
    Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, United Kingdom
    Proc Natl Acad Sci U S A 107:5545-50. 2010
    Membrane nanotubes are membranous tethers that physically link cell bodies over long distances. Here, we present evidence that nanotubes allow human natural killer (NK) cells to interact functionally with target cells over long distances...
  7. pmc Tunneling-nanotube development in astrocytes depends on p53 activation
    Y Wang
    Laboratory of Neurobiology and State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing, China
    Cell Death Differ 18:732-42. 2011
    Tunneling nanotubes (TNTs) can be induced in rat hippocampal astrocytes and neurons with H(2)O(2) or serum depletion. Major cytoskeletal component of TNTs is F-actin...
  8. doi Scalable fabrication of silicon nanotubes and their application to energy storage
    Jung Keun Yoo
    Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology KAIST, 291 Daehak ro, Yuseong Gu, Daejeon 305 701, Republic of Korea
    Adv Mater 24:5452-6. 2012
    The facile synthesis of silicon nanotubes using a surface sol-gel reaction on pyridine nanowire templates is reported and their performance for energy storage is investigated...
  9. doi TiO2 nanotubes for bone regeneration
    Karla S Brammer
    Materials Science and Engineering, University of California, San Diego, La Jolla, CA 92093 0411, USA
    Trends Biotechnol 30:315-22. 2012
    ..There is a growing body of data elucidating the benefits of using TiO(2) nanotubes for enhanced orthopedic implant surfaces...
  10. ncbi Tunneling nanotubes: a new route for the exchange of components between animal cells
    Hans Hermann Gerdes
    Department of Biomedicine, University of Bergen, Jonas Lies vei 91, Bergen 5009, Norway
    FEBS Lett 581:2194-201. 2007
    ..With respect to their peculiar architecture, these membrane channels were termed tunneling nanotubes (TNTs). TNTs could form de novo between animal cells leading to the generation of complex cellular networks...
  11. doi Diameter of titanium nanotubes influences anti-bacterial efficacy
    Batur Ercan
    School of Engineering, Brown University, Providence, RI 02917, USA
    Nanotechnology 22:295102. 2011
    ....
  12. ncbi Decreased Staphylococcus epidermis adhesion and increased osteoblast functionality on antibiotic-loaded titania nanotubes
    Ketul C Popat
    Department of Physiology, Division of Bioengineering, University of California, 1700 4th Street, Box 2520, San Francisco, CA 94143 2520, USA
    Biomaterials 28:4880-8. 2007
    ..These nanotubes were fabricated on bulk titanium using anodization techniques...
  13. doi Improved bone-forming functionality on diameter-controlled TiO(2) nanotube surface
    Karla S Brammer
    Materials Science and Engineering, University of California, San Diego, La Jolla, CA 92093 0411, USA
    Acta Biomater 5:3215-23. 2009
    ..We prepared various sizes (30-100 nm diameter) of titanium dioxide (TiO(2)) nanotubes on titanium substrates by anodization and investigated the osteoblast cellular behavior in response to these ..
  14. pmc Shape effects of filaments versus spherical particles in flow and drug delivery
    Yan Geng
    NanoBioPolymers and Molecular and Cell Biophysics Lab, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Nanotechnol 2:249-55. 2007
    ..Although these findings show that long-circulating vehicles need not be nanospheres, they also lend insight into possible shape effects of natural filamentous viruses...
  15. pmc Preferential transfer of mitochondria from endothelial to cancer cells through tunneling nanotubes modulates chemoresistance
    Jennifer Pasquier
    Stem Cell and Microenvironment Laboratory, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, Doha PO 24144, Qatar
    J Transl Med 11:94. 2013
    ..Recently, Tunneling nanotubes (TnTs) have been shown to support cell-to-cell transfers of plasma membrane components, cytosolic molecules and ..
  16. pmc TiO2 nanotube array sensor for detecting the SF6 decomposition product SO2
    Xiaoxing Zhang
    State Key Laboratory of Power Transmission Equipment and System Security and New Technology, Chongqing University, Chongqing 400044, China
    Sensors (Basel) 12:3302-13. 2012
    ....
  17. pmc Tunneling nanotubes mediate rescue of prematurely senescent endothelial cells by endothelial progenitors: exchange of lysosomal pool
    Kaoru Yasuda
    Department of Medicine, Renal Research Institute, New York Medical College, Valhalla, New York, USA
    Aging (Albany NY) 3:597-608. 2011
    ..Collectively, these data establish a selective multiplicative effect of TNT between EPC and stressed endothelia, reconstitution of the lysosomal pool, and improved viability and function of stressed endothelia...
  18. doi TiO2 nanotubes as drug nanoreservoirs for the regulation of mobility and differentiation of mesenchymal stem cells
    Yan Hu
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, People s Republic of China
    Acta Biomater 8:439-48. 2012
    ..More importantly, the system demonstrated that it was capable of promoting the osteoblastic differentiation of MSCs. This study may have potential impact on the development of bone implants for enhanced bone osseointegration...
  19. doi Detoxification of gold nanorods by conjugation with thiolated poly(ethylene glycol) and their assessment as SERS-active carriers of Raman tags
    Sanda C Boca
    Nanobiophotonics Center, Institute for Interdisciplinary Research in Nanobioscience, Babes Bolyai University, Cluj Napoca, Romania
    Nanotechnology 21:235601. 2010
    ..In this sense we successfully tested them as effective SERS substrates at 785 nm laser line with p-aminothiophenol (pATP) as a tag molecule...
  20. doi Folic acid-conjugated silica-modified gold nanorods for X-ray/CT imaging-guided dual-mode radiation and photo-thermal therapy
    Peng Huang
    National Key Laboratory of Nano Micro Fabrication Technology, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Institute of Micro Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, PR China
    Biomaterials 32:9796-809. 2011
    ..In conclusion, the as-prepared nanoprobe is a good candidate with excellent imaging and targeting ability for X-ray/CT imaging-guided targeting dual-mode enhanced RT and PTT...
  21. doi Intercellular transfer mediated by tunneling nanotubes
    Hans Hermann Gerdes
    Department of Biomedicine, University of Bergen, Jonas Lies vei 91, Bergen 5009, Norway
    Curr Opin Cell Biol 20:470-5. 2008
    ..In 2004, a new route of cell-to-cell communication mediated by tunneling nanotubes (TNT) was reported...
  22. ncbi Influence of engineered titania nanotubular surfaces on bone cells
    Ketul C Popat
    Department of Physiology Division of Bioengineering, University of California, 1700 4th Street, Box 2520, San Francisco, CA 94143 2520, USA
    Biomaterials 28:3188-97. 2007
    ..The fabrication routes of titania nano-architectures are flexible and cost-effective, enabling realization of desired platform topologies on existing non-planar orthopedic implants...
  23. doi Improved attachment of mesenchymal stem cells on super-hydrophobic TiO2 nanotubes
    Sebastian Bauer
    Department of Materials Science, WW4 LKO, Friedrich Alexander University of Erlangen Nuremberg, Germany
    Acta Biomater 4:1576-82. 2008
    Self-organized layers of vertically orientated TiO(2) nanotubes providing defined diameters ranging from 15 up to 100nm were grown on titanium by anodic oxidation. These TiO(2) nanotube layers show super-hydrophilic behavior...
  24. doi The influence of hierarchical hybrid micro/nano-textured titanium surface with titania nanotubes on osteoblast functions
    Lingzhou Zhao
    School of Stomatology, The Fourth Military Medical University, No 145 West ChangLe Road, Xi an 710032, China
    Biomaterials 31:5072-82. 2010
    Hierarchical hybrid micro/nano-textured titanium surface topographies with titania nanotubes were produced by simple acid etching followed by anodization to mimic the hierarchical structure of bone tissues...
  25. doi Titanium dioxide nanotubes enhance bone bonding in vivo
    Lars M Bjursten
    Department of Bioengineering, University of California San Diego, La Jolla, California, USA
    J Biomed Mater Res A 92:1218-24. 2010
    ..We investigate the in vivo bone bonding of two titanium implant surfaces: titanium dioxide (TiO(2)) nanotubes and TiO(2) gritblasted surfaces...
  26. doi RGD-conjugated dendrimer-modified gold nanorods for in vivo tumor targeting and photothermal therapy
    Zhiming Li
    Institute for Laser Medicine and Biophotonics, School of Life Sciences and Biotechnology, and National Key Laboratory of Nano Micro Fabrication Technology, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Institute of Micro Nano Science and Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
    Mol Pharm 7:94-104. 2010
    ..High-performance RGD-conjugated dendrimer-modified GNR nanoprobes exhibit great potential in applications such as tumor targeting, imaging, and selective photothermal therapy...
  27. pmc Silica-coated gold nanorods as photoacoustic signal nanoamplifiers
    Yun Sheng Chen
    Department of Biomedical Engineering, University of Texas at Austin, Austin, Texas 78712, USA
    Nano Lett 11:348-54. 2011
    ....
  28. doi In vivo evaluation of anodic TiO2 nanotubes: an experimental study in the pig
    Cornelius von Wilmowsky
    Department of Oral and Maxillofacial Surgery, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    J Biomed Mater Res B Appl Biomater 89:165-71. 2009
    ..of constituent components of natural bone and the possibility to serve as a gene and drug-delivery carrier, nanotubes seem to be a promising coating for medical implants...
  29. doi Intercellular nanotubes: insights from imaging studies and beyond
    Johan Hurtig
    Department of Chemistry, University of Washington, Seattle, WA 98195, USA
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 2:260-76. 2010
    ..reports suggest that cells also can communicate over long distances via a network of transient intercellular nanotubes. Such nanotubes have been shown to mediate intercellular transfer of organelles as well as membrane components ..
  30. ncbi Enhanced osteoblast functions on anodized titanium with nanotube-like structures
    Chang Yao
    School of Materials Engineering, 500 Central Drive, Purdue University, West Lafayette, Indiana 47907 2022, USA
    J Biomed Mater Res A 85:157-66. 2008
    ..minerals) were determined on titanium anodized to possess either heterogeneous nanoparticles or ordered nanotubes. Titanium was anodized in dilute hydrofluoric acid at 20 V for 20 min to possess nanotubes, while titanium was ..
  31. pmc Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity
    Andrew J Nicoll
    Medical Research Council Prion Unit and Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Nat Commun 4:2416. 2013
    ..Blocking the formation of Aβ nanotubes or their interaction with PrP might have a role in treatment of Alzheimer's disease.
  32. doi Cellular uptake and cytotoxicity of gold nanorods: molecular origin of cytotoxicity and surface effects
    Alaaldin M Alkilany
    Department of Chemistry and Biochemistry University of South Carolina Columbia, SC 29208, USA
    Small 5:701-8. 2009
    ..Such changes should be taken into consideration when examining the biological properties or environmental impact of nanoparticles...
  33. ncbi Increased osteoblast adhesion on nanophase metals: Ti, Ti6Al4V, and CoCrMo
    Thomas J Webster
    Department of Biomedical Engineering, Purdue University, 1296Patter Building, West Lafayette, IN 47905, USA
    Biomaterials 25:4731-9. 2004
    ..titania, and hydroxyapatite), polymers (such as poly lactic-glycolic acid and polyurethane), carbon nanofibers/nanotubes, and composites thereof...
  34. doi Multidimensional conducting polymer nanotubes for ultrasensitive chemical nerve agent sensing
    Oh Seok Kwon
    World Class University program of Chemical Convergence for Energy and Environment, School of Chemical and Biological Engineering, Seoul National University, Seoul 151 742, Korea
    Nano Lett 12:2797-802. 2012
    ..we demonstrate flexible nerve agent sensors, based on hydroxylated poly(3,4-ethylenedioxythiophene) (PEDOT) nanotubes (HPNTs) with surface substructures such as nanonodules (NNs) and nanorods (NRs)...
  35. doi TiO2 nanotubes on Ti: Influence of nanoscale morphology on bone cell-materials interaction
    Kakoli Das
    W M Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, USA
    J Biomed Mater Res A 90:225-37. 2009
    ..Ti could be made bioactive by several methods including growing in situ TiO2 layer on Ti-surface. TiO2 nanotubes were grown on Ti surface via anodization process and the bone cell-material interactions were evaluated...
  36. pmc Protein biosensors based on polymer nanowires, carbon nanotubes and zinc oxide nanorods
    M Anish Kumar
    Microelectronics Photonics, University of Arkansas, Fayetteville, AR 72701, USA
    Sensors (Basel) 11:5087-111. 2011
    ..One dimensional (1-D) structures such as nanowires, nanotubes and nanorods are proven to have high potential for bio-applications...
  37. doi RGD peptide immobilized on TiO2 nanotubes for increased bone marrow stromal cells adhesion and osteogenic gene expression
    Xin Cao
    Department of Prosthodontics, School of Stomatology and Affiliated Ninth People s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
    J Mater Sci Mater Med 23:527-36. 2012
    ..cellular adhesive peptide of arginine-glycine-aspartic acid-cysteine (RGDC) was immobilized onto anodized TiO(2) nanotubes on Ti to examine its in vitro responses on rat bone marrow stromal cells (BMSCs)...
  38. doi Laser immunotherapy with gold nanorods causes selective killing of tumour cells
    Rejiya C S
    Department of Biochemistry, University of Kerala, Kariavattom Campus, Thiruvananthapuram, Kerala, India
    Pharmacol Res 65:261-9. 2012
    ..Thus the results of our experiments confirmed that immunolabeled gold nanorods can selectively destruct the cancer cells and induce its apoptosis through ROS mediated mitochondrial pathway under low power laser exposure...
  39. ncbi Assessing the effect of surface chemistry on gold nanorod uptake, toxicity, and gene expression in mammalian cells
    Tanya S Hauck
    Institute of Biomaterials and Biomedical Engineering, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, 4th floor Toronto, ON M5S 3E1, Canada
    Small 4:153-9. 2008
    ..35% of genes examined). These results indicate that gold nanorods are well suited for therapeutic applications, such as thermal cancer therapy, due to their tunable cell uptake and low toxicity...
  40. doi A review of the application of anodization for the fabrication of nanotubes on metal implant surfaces
    Sepideh Minagar
    IRIS, Faculty of Engineering and Industrial Sciences, Swinburne University of Technology, Hawthorn, Victoria 3122, Australia
    Acta Biomater 8:2875-88. 2012
    ..Surface modification is essential for the promotion of the osseointegration of these biomaterials. Nanotubes fabricated on the surface of metal implants by anodization are receiving ever-increasing attention for surface ..
  41. ncbi Electrospinning of chitosan dissolved in concentrated acetic acid solution
    Xinying Geng
    School of Advanced Materials and System Engineering, Kumoh National Institute of Technology, 1 Yongho dong Kumi, Kyungbuk 730 701, Republic of Korea
    Biomaterials 26:5427-32. 2005
    ..Average fiber diameters and size distribution decreased with increasing electric field and more bead defects appeared at 5 kV/cm or more...
  42. doi Enhancement of neurite outgrowth in neuronal-like cells following boron nitride nanotube-mediated stimulation
    Gianni Ciofani
    Italian Institute of Technology c o Scuola Superiore Sant Anna, Viale Rinaldo Piaggio 34 Pontedera Pisa, 56025, Italy
    ACS Nano 4:6267-77. 2010
    ..Ultrasounds are used to impart mechanical stress to boron nitride nanotubes incubated with neuronal-like PC12 cells...
  43. doi Tailoring longitudinal surface plasmon wavelengths, scattering and absorption cross sections of gold nanorods
    Weihai Ni
    Department of Physics, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, P R China
    ACS Nano 2:677-86. 2008
    ..FDTD calculations further reveal that the scattering-to-extinction ratio increases linearly as a function of the diameter for Au nanorods with a fixed aspect ratio...
  44. doi Tunneling nanotubes: emerging view of their molecular components and formation mechanisms
    Shunsuke Kimura
    Laboratory of Histology and Cytology, Graduate School of Medicine, Hokkaido University, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    Exp Cell Res 318:1699-706. 2012
    ..Discovery of the role of M-Sec will accelerate our understanding of TNTs, both at the molecular and physiological levels...
  45. pmc Nanotubes, exosomes, and nucleic acid-binding peptides provide novel mechanisms of intercellular communication in eukaryotic cells: implications in health and disease
    Mattias Belting
    Lund University, Department of Clinical Sciences, Section of Oncology, Barngatan 2 1, SE 221 85 Lund, Sweden
    J Cell Biol 183:1187-91. 2008
    ..cells are restrained from intercellular exchange of genetic information has been challenged by recent reports on nanotubes, exosomes, apoptotic bodies, and nucleic acid-binding peptides that provide novel pathways for cell-cell ..
  46. doi Transfer of polyglutamine aggregates in neuronal cells occurs in tunneling nanotubes
    Maddalena Costanzo
    Institut Pasteur, Unité de Traffic Membranaire et Pathogenèse, 28 Rue du Docteur Roux 75724 Paris, Cedex 15, France
    J Cell Sci 126:3678-85. 2013
    ..Interestingly, we found that the expression of mutant, but not wild-type Htt fragments, increases the number of tunneling nanotubes, which in turn provide an efficient mechanism of transfer.
  47. doi Mesoporous silica-coated gold nanorods with embedded indocyanine green for dual mode X-ray CT and NIR fluorescence imaging
    Teng Luo
    School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China
    Opt Express 19:17030-9. 2011
    ..The dual mode imaging probe has great potential for use in applications such as cancer targeting, molecular imaging in combination with radiotherapy, and photothermolysis...
  48. pmc Light-induced release of DNA from gold nanoparticles: nanoshells and nanorods
    Ryan Huschka
    Department of Chemistry, Rice University, Houston, Texas 77005, USA
    J Am Chem Soc 133:12247-55. 2011
    ..These results suggest that a nonthermal mechanism may play a role in plasmon resonant, light-triggered DNA release...
  49. pmc Ordered assembly of murine leukemia virus capsid protein on lipid nanotubes directs specific binding by the restriction factor, Fv1
    Laura Hilditch
    Division of Virology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Proc Natl Acad Sci U S A 108:5771-6. 2011
    ..C-terminally His-tagged CA molecules were assembled on Ni-chelating lipid nanotubes, and analysis by electron microscopy revealed the formation of a regular lattice...
  50. pmc Gold nanorods as contrast agents for biological imaging: optical properties, surface conjugation and photothermal effects
    Ling Tong
    Department of Chemistry, Purdue University, West Lafayette, IN, USA
    Photochem Photobiol 85:21-32. 2009
    ..The combination of plasmon-resonant optical properties, intense local photothermal effects and robust surface chemistry render gold NRs as promising theragnostic agents...
  51. doi Controlled-release system of single-stranded DNA triggered by the photothermal effect of gold nanorods and its in vivo application
    Shuji Yamashita
    Department of Applied Chemistry, Faculty of Engineering, Kyushu University, 744 Motooka, Nishi ku, Fukuoka 819 0395, Japan
    Bioorg Med Chem 19:2130-5. 2011
    ..Such a controlled-release system of oligonucleotide triggered by the photothermal effect could expand the applications of gold nanorods that have unique optical characteristics in medicinal fields...
  52. pmc Two-photon luminescence imaging of cancer cells using molecularly targeted gold nanorods
    Nicholas J Durr
    Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas 78712, USA
    Nano Lett 7:941-5. 2007
    ....
  53. pmc Tunneling nanotubes provide a unique conduit for intercellular transfer of cellular contents in human malignant pleural mesothelioma
    Emil Lou
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 7:e33093. 2012
    Tunneling nanotubes are long, non-adherent F-actin-based cytoplasmic extensions which connect proximal or distant cells and facilitate intercellular transfer...
  54. pmc Aerobic biogenesis of selenium nanospheres by Bacillus cereus isolated from coalmine soil
    Soniya Dhanjal
    Institute of Microbial Technology, Sector 39 A, Chandigarh 160036, India
    Microb Cell Fact 9:52. 2010
    ..Biosynthesis of selenium (Se 0) nanospheres in aerobic conditions by a bacterial strain isolated from the coalmine soil is reported in the present study...
  55. pmc Control of self-assembly of DNA tubules through integration of gold nanoparticles
    Jaswinder Sharma
    Center for Single Molecule Biophysics, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA
    Science 323:112-6. 2009
    ..By the attachment of single-stranded DNA to gold nanoparticles, nanotubes of various 3D architectures can form, ranging in shape from stacked rings to single spirals, double spirals, and ..
  56. doi Selective release of multiple DNA oligonucleotides from gold nanorods
    Andy Wijaya
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    ACS Nano 3:80-6. 2009
    ..Releases were efficient (50-80%) and externally tunable by laser fluence. Released oligonucleotides were still functional. This proof of concept is potentially a powerful method for multiple-drug delivery strategies...
  57. doi Tailoring the atomic structure of graphene nanoribbons by scanning tunnelling microscope lithography
    Levente Tapasztó
    Nat Nanotechnol 3:397-401. 2008
    ..In spite of the exceptional electronic properties of carbon nanotubes, only basic demonstration devices have been realized that require time-consuming processes...
  58. ncbi Influence of preparation conditions on acyclovir-loaded poly-d,l-lactic acid nanospheres and effect of PEG coating on ocular drug bioavailability
    Claudia Giannavola
    Department of Pharmaceutical Sciences, University of Catania, I 95125 Catania, Italy
    Pharm Res 20:584-90. 2003
    ..The ocular pharmacokinetics of acyclovir-loaded nanoparticles was evaluated in vivo and compared with an aqueous suspension of the free drug...
  59. pmc Photoacoustic imaging of mesenchymal stem cells in living mice via silica-coated gold nanorods
    Jesse V Jokerst
    Molecular Imaging Program at Stanford, Department of Radiology, 318 Campus Drive, Stanford University, Stanford, California 94305 5427, United States
    ACS Nano 6:5920-30. 2012
    ..This approach has significant advantages over traditional cell imaging techniques like positron emission tomography and magnetic resonance imaging including real time monitoring of stem cell therapy...
  60. doi Long-distance intercellular connectivity between cardiomyocytes and cardiofibroblasts mediated by membrane nanotubes
    Kangmin He
    Institute of Vascular Medicine of Third Hospital, Ministry of Education Key Lab of Molecular Cardiovascular Sciences, Ministry of Health Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides and Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100191, PR China
    Cardiovasc Res 92:39-47. 2011
    ..However, until recently, little has been known about these interactions. We aimed to investigate structural and functional connections between CMs and FBs that are distinct from gap junctions...
  61. doi Narrow band imaging of squamous cell carcinoma tumors using topically delivered anti-EGFR antibody conjugated gold nanorods
    Priyaveena Puvanakrishnan
    Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas 78712, USA
    Lasers Surg Med 44:310-7. 2012
    ..Near-infrared (NIR) NBI images narrow wavelength bands to enhance contrast from plasmonic particles in a wide field portable and noncontact device that is clinically compatible for real-time tumor imaging and tumor margin demarcation...
  62. doi Matrix metalloproteinase sensitive gold nanorod for simultaneous bioimaging and photothermal therapy of cancer
    Dong Kee Yi
    Division of Bionanotechnology, Gachon Bionano Institute, Kyungwon University, Geonggi do 461 701, Korea
    Bioconjug Chem 21:2173-7. 2010
    ..The results suggested potential application of MMP-AuNR for simultaneous cancer diagnosis and therapy...
  63. pmc Simultaneous enhancement of photothermal stability and gene delivery efficacy of gold nanorods using polyelectrolytes
    Huang Chiao Huang
    Chemical Engineering, Arizona State University, Tempe, Arizona 85287 6106, USA
    ACS Nano 3:2941-52. 2009
    ....
  64. doi Biological applications of gold nanorods
    John Stone
    Department of Chemistry, Vanderbilt University, Nashville, TN, USA
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 3:100-9. 2011
    ..This article highlights established and emerging applications of gold nanorods as a platform for viable biological tools...
  65. pmc Reduced adhesion of macrophages on anodized titanium with select nanotube surface features
    Amancherla Rajyalakshmi
    Non Ferrous Materials Technology Development Centre, Hyderabad, India
    Int J Nanomedicine 6:1765-71. 2011
    ..Anodization of titanium (Ti) leads to the formation of TiO(2) nanotubes on the surface, and the presence of these nanotubes mimics the natural nanoscale features of bone, which in turn ..
  66. doi The role of sterilization in the cytocompatibility of titania nanotubes
    Lingzhou Zhao
    School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi an 710032, China
    Biomaterials 31:2055-63. 2010
    Titiania nanotubes have large potential in medical implant applications but their tissue compatibility is still controversial...
  67. doi Intrinsically fluorescent carbon nanospheres as a nuclear targeting vector: delivery of membrane-impermeable molecule to modulate gene expression in vivo
    B Ruthrotha Selvi
    Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore 560 064, India
    Nano Lett 8:3182-8. 2008
    ..These results establish an alternative path for the activation of gene expression mediated by the induction of HAT activity instead of histone deacetylase (HDAC) inhibition...
  68. doi Intercellular transportation of quantum dots mediated by membrane nanotubes
    Kangmin He
    Academy for Advanced Interdisciplinary Studies and Institute of Vascular Medicine of Third Hospital, Ministry of Education Key Lab of Molecular Cardiovascular Sciences, Peking University, Beijing, 100191, China
    ACS Nano 4:3015-22. 2010
    In this work, we reported that the quantum dot (QD) nanoparticles could be actively transported in the membrane nanotubes between cardiac myocytes...
  69. doi Light interactions with gold nanorods and cells: implications for photothermal nanotherapeutics
    Constantin Ungureanu
    Biomedical Photonic Imaging Group, MIRA Institute for Biomedical Technology and Technical Medicine, Faculty of Science and Technology, University of Twente, P O Box 217, 7500 AE Enschede, The Netherlands
    Nano Lett 11:1887-94. 2011
    ..Both effects create sufficiently high optical absorption at 532 nm, which otherwise would have been present at the LP peak. We discuss implications of these finding on the application of these particles in biomedicine...
  70. doi Gold nanorods: their potential for photothermal therapeutics and drug delivery, tempered by the complexity of their biological interactions
    Alaaldin M Alkilany
    Department of Chemistry, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Adv Drug Deliv Rev 64:190-9. 2012
    ..Issues of dosage, toxicity and biological interactions at three levels (biological media alone; cells; whole organisms) are discussed, concluding with recommendations for future work in this area...
  71. pmc Greater osteoblast proliferation on anodized nanotubular titanium upon electrical stimulation
    Batur Ercan
    Division of Engineering, Brown University, Providence, RI 02912, USA
    Int J Nanomedicine 3:477-85. 2008
    ..Thus, results of this study suggest that coupling the positive influences of electrical stimulation and nanotubular features on anodized titanium may improve osteoblast responses necessary for enhanced orthopedic implant efficacy...
  72. doi Self-ordered nanopore and nanotube platforms for drug delivery applications
    Dusan Losic
    University of South Australia, Ian Wark Research Institute, Mawson Lakes Campus, Mawson Lakes, Adelaide, SA 5095, Australia
    Expert Opin Drug Deliv 6:1363-81. 2009
    ..The basic concept of fabrication of these unique materials using a self-ordering process, description of their structural properties, biocompatibility and recent applications for therapeutic implants is presented...
  73. doi Long-term small molecule and protein elution from TiO2 nanotubes
    Lily Peng
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California 94158 2330, USA
    Nano Lett 9:1932-6. 2009
    In this study, TiO(2) nanotubes of various dimensions were used to elute albumin, a large protein molecule, as well as sirolimus and paclitaxel, common small molecule drugs...
  74. pmc Investigation of interactions between poly-L-lysine-coated boron nitride nanotubes and C2C12 cells: up-take, cytocompatibility, and differentiation
    G Ciofani
    Scuola Superiore Sant Anna, Pisa, Italy
    Int J Nanomedicine 5:285-98. 2010
    Boron nitride nanotubes (BNNTs) have generated considerable interest within the scientific community by virtue of their unique physical properties, which can be exploited in the biomedical field...
  75. pmc Biomimetic helical rosette nanotubes and nanocrystalline hydroxyapatite coatings on titanium for improving orthopedic implants
    Lijie Zhang
    Division of Engineering, Brown University, Providence, RI 02912, USA
    Int J Nanomedicine 3:323-33. 2008
    ..In addition, helical rosette nanotubes (HRNs), newly developed materials which form through the self-assembly process of DNA base pair building blocks ..
  76. pmc Biocompatible nanoscale dispersion of single-walled carbon nanotubes minimizes in vivo pulmonary toxicity
    Gokhan M Mutlu
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Evanston, IL 60208, USA
    Nano Lett 10:1664-70. 2010
    Excitement surrounding the attractive physical and chemical characteristics of single walled carbon nanotubes (SWCNTs) has been tempered by concerns regarding their potential health risks...
  77. ncbi Inorganic hollow nanoparticles and nanotubes in nanomedicine Part 1. Drug/gene delivery applications
    Sang Jun Son
    Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA
    Drug Discov Today 12:650-6. 2007
    Recent cytotoxicity studies on carbon nanotubes have shown that the biocompatibility of nanomaterial might be determined mainly by surface functionalization, rather than by size, shape, and material...
  78. doi TiO2 nanotubes and their application in dye-sensitized solar cells
    Poulomi Roy
    Department of Materials Science, University of Erlangen Nurnberg, Martensstrasse 7, Erlangen, Germany
    Nanoscale 2:45-59. 2010
    The present article reviews the current status of using TiO(2) nanotubes in Grätzel-type, dye-sensitized solar cells and extends the overview with the latest results and findings...
  79. pmc Gold nanocages: synthesis, properties, and applications
    Sara E Skrabalak
    Department of Chemistry, University of Washington, Seattle, Washington 98195, USA
    Acc Chem Res 41:1587-95. 2008
    ..This approach is versatile, with a wide range of morphologies (e.g., nanorings, prism-shaped nanoboxes, nanotubes, and multiple-walled nanoshells or nanotubes) available upon changing the shape of the initial Ag template...
  80. ncbi Enhanced charge-collection efficiencies and light scattering in dye-sensitized solar cells using oriented TiO2 nanotubes arrays
    Kai Zhu
    National Renewable Energy Laboratory, Golden, Colorado 80401 3393, USA
    Nano Lett 7:69-74. 2007
    ..Analysis of photocurrent measurements indicates that the light-harvesting efficiencies of NT-based DSSCs were higher than those found for DSSCs incorporating NPs owing to stronger internal light-scattering effects...
  81. pmc Enhanced thermal stability of silica-coated gold nanorods for photoacoustic imaging and image-guided therapy
    Yun Sheng Chen
    Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, 78712, USA
    Opt Express 18:8867-78. 2010
    ....
  82. pmc Animal cells connected by nanotubes can be electrically coupled through interposed gap-junction channels
    Xiang Wang
    Department of Biomedicine, University of Bergen, 5009 Bergen, Norway
    Proc Natl Acad Sci U S A 107:17194-9. 2010
    Tunneling nanotubes (TNTs) are recently discovered conduits for a previously unrecognized form of cell-to-cell communication...
  83. ncbi Chemically functionalized carbon nanotubes
    Kannan Balasubramanian
    Max Planck Institut fur Festkorperforschung, Heisenbergstrasse 1, 70569 Stuttgart, Germany
    Small 1:180-92. 2005
    Since their discovery, carbon nanotubes have attracted the attention of many a scientist around the world. This extraordinary interest stems from their outstanding structural, mechanical, and electronic properties...
  84. pmc Gold nanorod delivery of an ssRNA immune activator inhibits pandemic H1N1 influenza viral replication
    Krishnan V Chakravarthy
    Department of Anesthesiology and Microbiology and Immunology, State University of New York, Buffalo, NY 14214, USA
    Proc Natl Acad Sci U S A 107:10172-7. 2010
    ..These findings suggest that further evaluation of biocompatible nanoplexes as unique antivirals for treatment of seasonal and pandemic influenza viruses is warranted...
  85. pmc Spatiotemporal temperature distribution and cancer cell death in response to extracellular hyperthermia induced by gold nanorods
    Huang Chiao Huang
    Chemical Engineering, Arizona State University, Tempe, Arizona 85287 6106, USA
    ACS Nano 4:2892-900. 2010
    ..Taken together, extracellular hyperthermia using gold nanorods is a promising strategy, and tailoring the cellular binding efficacy of nanorods can result in varying therapeutic efficacies using this approach...
  86. doi Selective block of tunneling nanotube (TNT) formation inhibits intercellular organelle transfer between PC12 cells
    Nickolay V Bukoreshtliev
    Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Hordaland, Norway
    FEBS Lett 583:1481-8. 2009
    Organelle exchange between cells via tunneling nanotubes (TNTs) is a recently described form of intercellular communication...
  87. doi Tunneling nanotube (TNT)-like structures facilitate a constitutive, actomyosin-dependent exchange of endocytic organelles between normal rat kidney cells
    Steffen Gurke
    Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    Exp Cell Res 314:3669-83. 2008
    ..Taken together, our data indicate a frequent and continuous exchange of endocytic organelles between cells via TNT by an actomyosin-dependent mechanism...
  88. ncbi Preparation and characterization of cationic PLGA nanospheres as DNA carriers
    M N V Ravi Kumar
    Department of Biopharmaceutics and Pharmaceutical Technology, Saarland University, D 66123, Saarbrucken, Germany
    Biomaterials 25:1771-7. 2004
    ..These cationic PLGA nanospheres could serve as potential alternatives of the existing negatively charged nanoparticles...
  89. ncbi Electrospun P(LLA-CL) nanofiber: a biomimetic extracellular matrix for smooth muscle cell and endothelial cell proliferation
    X M Mo
    Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, 117576, Singapore, Singapore
    Biomaterials 25:1883-90. 2004
    ..The biocompatibility of the nanofiber scaffold has been investigated by culturing cells on the nanofiber scaffold. Both smooth muscle cell and endothelial cell adhered and proliferated well on the P(LLA-CL) nanofiber scaffolds...
  90. pmc Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice
    Erin B Dickerson
    School of Biology, Ovarian Cancer Institute, Georgia Institute of Technology, Atlanta, GA 30332 0400, USA
    Cancer Lett 269:57-66. 2008
    ..Inhibition of average tumor growth for both delivery methods was observed over a 13-day period, with resorption of >57% of the directly-injected tumors and 25% of the intravenously-treated tumors...
  91. doi TiO2 nanotubes: synthesis and applications
    Poulomi Roy
    Department of Materials Science, WW4 LKO, University of Erlangen Nuremberg, Erlangen, Germany
    Angew Chem Int Ed Engl 50:2904-39. 2011
    ..In 1999, first reports showed the feasibility to grow highly ordered arrays of TiO(2) nanotubes by a simple but optimized electrochemical anodization of a titanium metal sheet...
  92. doi Long vertically aligned titania nanotubes on transparent conducting oxide for highly efficient solar cells
    Oomman K Varghese
    1 Materials Research Institute, Department of Electrical Engineering, The Pennsylvania State University, University Park, PA 16802, USA
    Nat Nanotechnol 4:592-7. 2009
    ..Dye-sensitized solar cells containing these arrays yielded a power conversion efficiency of 6.9%. The incident photon-to-current conversion efficiency ranged from 70 to 80% for wavelengths between 450 and 650 nm...
  93. doi Intercellular nanotubes mediate bacterial communication
    Gyanendra P Dubey
    Department of Microbiology and Molecular Genetics, Institute for Medical Research Israel Canada, The Hebrew University Hadassah Medical School, The Hebrew University of Jerusalem, Israel
    Cell 144:590-600. 2011
    ..Here we identify a previously uncharacterized type of bacterial communication mediated by nanotubes that bridge neighboring cells...
  94. ncbi Formation of nanotubes and hollow nanoparticles based on Kirkendall and diffusion processes: a review
    Hong Jin Fan
    Department of Earth Sciences, University of Cambridge, CB2 3EQ Cambridge, UK
    Small 3:1660-71. 2007
    ..In this Review we summarize and discuss the demonstrated examples of hollow nanoparticles and nanotubes induced by the Kirkendall effect...
  95. pmc Boron nitride nanotubes are noncytotoxic and can be functionalized for interaction with proteins and cells
    Xing Chen
    Department of Chemistry, University of California, Berkeley, Berkeley, California 94720, USA
    J Am Chem Soc 131:890-1. 2009
    We report the discovery that boron nitride nanotubes (BNNTs), isosteres of CNTs with unique physical properties, are inherently noncytotoxic...
  96. doi The effect of TiO2 nanotubes on endothelial function and smooth muscle proliferation
    Lily Peng
    Department of Bioengineering and Therapeutic Sciences, University of California, Box 2520, Byers Hall Rm 203C, San Francisco, CA 94158 2330, USA
    Biomaterials 30:1268-72. 2009
    ..EC and VSMC response to nanotubes was investigated through immunofluorescence staining, scanning electron microscopy, 5-ethynyl-2'-deoxyuridine ..
  97. pmc Label-free plasmonic detection of biomolecular binding by a single gold nanorod
    Greg J Nusz
    Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
    Anal Chem 80:984-9. 2008
    ..3 nm. Binding of streptavidin at 1 nM concentration induces a mean resonant wavelength shift of 0.59 nm suggesting that we are currently operating at close to the limit of detection of the system...
  98. doi In vitro behavior of MC3T3-E1 preosteoblast with different annealing temperature titania nanotubes
    W Q Yu
    Department of Prosthodontics, Ninth People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, China
    Oral Dis 16:624-30. 2010
    ..It is necessary to evaluate osteoblast behavior on different annealing temperature titania nanotubes for actual implant designs.
  99. doi Detection of glucose based on direct electron transfer reaction of glucose oxidase immobilized on highly ordered polyaniline nanotubes
    Ziyi Wang
    Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Environmental Science, Nanjing Normal University, Nanjing 210097, PR China
    Anal Chem 81:1638-45. 2009
    ..GOx) was developed by electrochemically entrapping GOx onto the inner wall of highly ordered polyaniline nanotubes (nanoPANi), which was synthesized using anodic aluminum oxide (AAO) membrane as a template...
  100. ncbi Dynamic behaviors of lipid-like self-assembling peptide A6D and A6K nanotubes
    Aki Nagai
    Center for Biomedical Engineering NE47 379, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 4307, USA
    J Nanosci Nanotechnol 7:2246-52. 2007
    ..structures of lipid-like designer peptide A6D (AAAAAAD) and A6K (AAAAAAK) that undergo self-assembly into nanotubes in water and salt solution...
  101. doi In situ enzymatic ascorbic acid production as electron donor for CdS quantum dots equipped TiO2 nanotubes: a general and efficient approach for new photoelectrochemical immunoassay
    Wei Wei Zhao
    State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China
    Anal Chem 84:10518-21. 2012
    ..Thioglycolic acid-capped CdS quantum dots (QDs) equipped TiO(2) nanotubes (NTs) were fabricated via a facile electrostatic adsorption method...

Research Grants73

  1. Nanospheres as Delivery Vehicles for Psoriasis Therapeutics
    LARISA contact SHEIHET; Fiscal Year: 2010
    ..The nanosphere design is highly versatile and will significantly contribute to topical drug delivery applications. ..
  2. Carbon Nanotube Fibers as Implantable Neural Electrodes
    Douglas Adamson; Fiscal Year: 2009
    ..Fabricated from single wall carbon nanotubes (SWNT) with a polymer binder in the form of flexible "hair-like" fibers, CNF combine unique properties of porous ..
  3. ORGANIC NANOTUBES DESIGN AND BIOLOGICAL APPLICATIONS
    M Ghadiri; Fiscal Year: 2009
    ..Self-assembling peptide nanotubes are a versatile class of synthetic supramolecular structures with considerable potential for addressing this ..
  4. Targeted siRNA nanotechnology for intravesical treatment of urologicaldiseases
    Robert M Weiss; Fiscal Year: 2010
    ..Our first test of these nanoparticles will use a mouse model of bladder cancer. Thus, we can determine the therapeutic potential of siRNA for treatment of urologic diseases. ..
  5. CHEMISTRY AND BIOLOGY OF PLATINUM ANTICANCER DRUGS
    Stephen J Lippard; Fiscal Year: 2013
    ..Carbon nanotubes and biodegradable nanoparticles are devised to deliver platinum prodrugs selectively to cancer cells, targeting ..
  6. Chronic Granulomatous Lung Inflammation Elicited by Carbon Nanotubes
    Mary Jane Thomassen; Fiscal Year: 2013
    ..Combustion-generated multiwall carbon nanotubes (MWCNT) or nanoparticles are ubiquitous in non-manufacturing environments and detectable in vapors from diesel ..
  7. Lung Toxicity of Carbon Nanotubes in Models of Pre-Existing Respiratory Disease
    JAMES CHRISTOPHER BONNER; Fiscal Year: 2010
    ..Carbon Nanotubes (CNTs) are engineered nanomaterials designed for multiple uses (electronics, engineering, medicine), but have ..
  8. Tumor -Targeting Chemotherapeutic Agents
    Iwao Ojima; Fiscal Year: 2013
    ..multiple guiding modules as well as warheads, we will explore the high potentials of single-walled carbon nanotubes (SWNTs), ultra-short SWNTs and dendrimers, as well as drug conjugates with small-molecule splitter modules...
  9. Mechanics of Inner Ear Hair Bundles
    KIRIAKI DOMENICA KARAVITAKI; Fiscal Year: 2012
    ..a silicon based V-shaped stimulation probe will be microfabricated and its tip will be coated with carbon nanotubes (CNTs) to promote adhesion of the probe to the cochlear bundles...
  10. Microvascular Health and Nanoparticle Exposure
    Timothy R Nurkiewicz; Fiscal Year: 2010
    ..Considering the widespread use of titania based products and carbon nanotubes throughout the U.S...
  11. Long-Term Non-Enzymatic Glucose Sensors for an Artificial Pancreas
    NATALIE ANN WISNIEWSKI; Fiscal Year: 2013
    ..Refinement of fluorescent tissue-intergrating sensors promises to open a whole new sensing modality for diabetes management and health monitoring. ..
  12. Novel approaches to evaluate carbon nanotube health impacts
    KENT ED PINKERTON; Fiscal Year: 2010
    ..Carbon-based engineered nanomaterials, such as single-walled carbon nanotubes (SWCNTs), have received notable attention due to their superior electronic, optical, mechanical, chemical, or ..
  13. BIOSENSOR ARRAYS BASED ON SINGLE WALL CARBON NANOTUBES
    James F Rusling; Fiscal Year: 2010
    ..highly sensitive micro- and nano-biosensor arrays for proteins and bacteria using patterned single-walled carbon nanotubes (SWNTs) and biomolecule recognition elements...
  14. Chiral Microchip Electrophoresis - Mass Spectrometric Methods for Metabolic Studi
    Yiming Liu; Fiscal Year: 2013
    ..We plan to covalently attach chiral selector molecules onto shortened single walled carbon nanotubes and then to immobilize the chiral selector-bonded carbon nanotubes in the channel, producing highly effective ..
  15. Developing fluorescent probes for the endogenous gaseous transmitters NO and H2S
    MICHAEL PLUTH; Fiscal Year: 2013
    ..Adsorption or covalent attachment of such complexes to solubilized single-walled carbon nanotubes (SWNTs) will be used to develop NO-selective probes that emit in the NIR...
  16. Genetic Susceptibility to Nanoparticle-Induced Respiratory Disease
    JAMES CHRISTOPHER BONNER; Fiscal Year: 2013
    ..Carbon Nanotubes (CNTs) are a major type of engineered nanomaterial designed and modified at the atomic level for multiple uses (..
  17. Biodegradable Polymeric Nanosphere Drug Delivery System For Cancer Chemotherapy
    Emmanuel O Akala; Fiscal Year: 2010
    ....
  18. Application of Carbon Nanotubes for Macrophage Activation in Brain Tumor Models
    Behnam Badie; Fiscal Year: 2010
    ..One example is carbon nanotubes (CNT), which are unique nanostructures with remarkable electronic and mechanical properties...
  19. Gated Carbon Nanotube Membrane Transdermal Drug Delivery
    BRUCE JACKSON HINDS; Fiscal Year: 2013
    ..Recently we have developed a method to form a permeable membrane based on the hollow cores of carbon-nanotubes (CNT) passing perpendicularly through a polymer film. These inner-cores are 7...
  20. C60, MWCNTs and the Influence on Cardiovascular, Reproductive, and Developmental
    Timothy R Fennell; Fiscal Year: 2013
    ..Institute of Environmental Health Sciences to investigate the cardiovascular and pulmonary responses of carbon nanotubes. Data developed by RTI and ECU researchers will be used by scientists at The Hamner Institutes for Health ..
  21. Tumor Targeting and Diagnostic Applications of Glycosylated Nanotubes
    RAVI N SINGH; Fiscal Year: 2011
    ..The goal of this research is to develop a new agent based on multiwalled carbon nanotubes (MWCNT) for the diagnosis and monitoring of advanced breast cancer...
  22. MicroRNA pathway in mechanisms of nanoparticles neurotoxicity
    Alexander K Murashov; Fiscal Year: 2010
    ..One category of nanomaterial includes carbon nanotubes (CNTs), which are allotropes of carbon with a cylindrical nanostructure...
  23. Contribution of Toll-like Receptors in the Pulmonary Response to Nanoparticles an
    TARA L SABO-ATTWOOD; Fiscal Year: 2013
    ..We have a particular interest in single-walled carbon nanotubes (SWNT) as they are widely used and possess a superficial resemblance to asbestos which may be relevant to their ..
  24. Fate and effects of nanomaterials in the gastrointestinal tract
    Celine A Beamer; Fiscal Year: 2012
    ..Of these nanomaterials, carbon nanotubes (CNTs) are fullerene-related graphene cylinders that exhibit highly desirable properties, yet also display ..
  25. Calcium Signals Within Membrane Nanotubes
    Ian F Smith; Fiscal Year: 2013
    ..A new route of cell-to-cell communication has recently been identified via tunneling membrane nanotubes (TNTs)...
  26. Control of Macromolecular Traffic Through Plasmodesmata
    VITALY H CITOVSKY; Fiscal Year: 2013
    ..These connections, termed tunneling nanotubes (TNTs) in mammals and plasmodesmata (Pd) in plants, are subverted by invading pathogens for their movement ..
  27. Novel nanotechnology based oral influenza vaccines
    Sang Moo Kang; Fiscal Year: 2011
    ..abstract_text> ..
  28. Enzyme-Responsive Nanoemulsions as Tumor-Specific Ultrasound Contrast Agents for
    Andrew P Goodwin; Fiscal Year: 2011
    ..Hongjie Dai, where he functionalized carbon nanotubes and gold nanostructures with new synthetic biocompatible assemblies to create novel hybrid nanostructures with ..
  29. Nanotechnology-based Theranostic Technology for Bone Tissue Engineering
    Balaji Sitharaman; Fiscal Year: 2010
    ..technology harnesses the physical properties of innovative multifunctional nanomaterials (single-walled carbon nanotubes and gold nanoparticles), and an acoustic wave phenomenon induced by nanosecond electromagnetic pulses known as ..
  30. Tumor Targeting and Diagnostic Applications of Glycosylated Nanotubes
    RAVI N SINGH; Fiscal Year: 2013
    ..The goal of this research is to develop a new agent based on multiwalled carbon nanotubes (MWCNT) for the diagnosis and monitoring of advanced breast cancer...
  31. Endothelial Cells as Biosensors for Occupational Cardiovascular Risk
    Matthew J Campen; Fiscal Year: 2013
    ..are to develop this model for rodent species and explore the relative impact of inhaled multiwalled carbon nanotubes (MWCNTs) and graphene...
  32. Optimization of SWCNT/siRNA complex formulation for tumor accumulation
    Lynn Kirkpatrick; Fiscal Year: 2012
    ..or applied for by Ensysce and the company has initiated a number of research programs to utilize carbon nanotubes to treat cancer including that described herein to deliver short interfering RNAs (siRNA)...
  33. Interactions of engineered nanomaterials with lung alveolar epithelium
    EDWARD DAVID CRANDALL; Fiscal Year: 2010
    ..engineered/manufactured nanomaterials (ENM: examples are fullerenes (composed of >60 carbon atoms), carbon nanotubes (CNT), quantum dots and metal /metal oxide nanoparticles), may be associated with various heart-, blood- and ..
  34. Enzyme-Responsive Nanoemulsions as Tumor-Specific Ultrasound Contrast Agents
    Andrew P Goodwin; Fiscal Year: 2013
    ..Hongjie Dai, where he functionalized carbon nanotubes and gold nanostructures with new synthetic biocompatible assemblies to create novel hybrid nanostructures with ..
  35. Feasibility study: endoscopic surface-enhanced Raman spectroscopy (SERS) for in s
    Martin Feldman; Fiscal Year: 2013
    ..A mixture of molecules with various mixing ratio will be examined also with a SERS probe and the principal component analysis to assess the accuracy of the method. ..
  36. Systematic assessment of multi-walled carbon nanotubes in pulmonary disease
    Nancy Lan Guo; Fiscal Year: 2013
    ..Results will fill th gap between in vivo/in vitro MWCNT-induced toxicity studies and risk assessment in humans. ..
  37. Spin Probes in Semipermeable Nanospheres: EPR spectroscopy & imaging of tumor pH
    VALERY KHRAMTSOV; Fiscal Year: 2009
    ....
  38. DETERMINATION AND EXPRESSION OF AMELOGENIN GENE PRODUCTS
    Malcolm L Snead; Fiscal Year: 2012
    ....
  39. Vascular Consequences of Multi-Walled Carbon Nanotube Exposure
    PHOEBE STAPLETON; Fiscal Year: 2013
    ..Yet, the systemic health consequences of ENM exposures remain unclear. Specifically, multi-walled carbon nanotubes (MWCNT) have been robustly developed due to their highly desirable mechanical properties and substantial surface ..
  40. How do Nanoparticles Target Cancer? An In Vivo Experimental/Mathematical Study
    Bryan Ronain Smith; Fiscal Year: 2012
    ..microscopy experiments on several NP types (with varied physical properties, such as quantum dots and nanotubes) in living mice that display broadly different targeting characteristics across the NP types we have tested...
  41. Carbon Nanotubes as Multi-functional Spectroscopic Markers and Delivery Agents fo
    Hongjie Dai; Fiscal Year: 2012
    ..In this proposal, we plan to develop new functionalization chemistry for single-walled nanotubes (SWNTs) to achieve tumor specific delivery of chemotherapeutics...
  42. Pulmonary Innate Immune Modulation by Helical Carbon Nanotubes
    BRENT WALLING; Fiscal Year: 2013
    ..Carbon nanotubes, a relatively new nanoparticulate which has seen a marked increase in production due to multiple potential ..
  43. Prediction and Mechanism of Carbon Nanotube-Induced Fibrosis
    Yon Rojanasakul; Fiscal Year: 2013
    ..Recent studies have shown that pulmonary exposure to carbon nanotubes (CNT), one of the most widely used nanomaterials in industry, results in rapid and progressive interstitial lung ..
  44. Sensitive and multiplexed analysis of cancer biomarkers with QD barcodes
    Xiaohu Gao; Fiscal Year: 2012
    ..We will further carry out experiments to detect mutations on both DNA and RNA level as well as the profiles of protein cancer biomarkers, which can be isolated from serum or homogenized cell and tissue specimens. ..
  45. Characterization Methodologies &Proteomics to Assess Carbon Nanotube Exposure
    Frank A Witzmann; Fiscal Year: 2012
    ..While raw, unrefined, and hydrophobic carbon nanotubes tend to settle out of aqueous media/environs, water dispersible, functionalized carbon nanotubes (f-CNTs) will ..
  46. Measuring and monitoring carbon nanotubes and their potential toxicity
    ROCKFORD KEITH DRAPER; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The Environmental Protection Agency (EPA) recently classified carbon nanotubes (CNTs) as a new chemical substance...
  47. Carbon Nanotube Biodegradation by Neutrophil Myeloperoxidase
    Valerian E Kagan; Fiscal Year: 2013
    ..Kagan, PhD, DSc Widespread applications of engineered nanomaterials, particularly carbon nanotubes (CNT), in different spheres of industry, consumer products, and medicine raise concerns about their possible ..
  48. Cardio-vascular Impact of Inhaled Multi-wall Carbon Nanotubes
    Christopher J Wingard; Fiscal Year: 2010
    DESCRIPTION (provided by applicant) Carbon nanotubes exhibit exceptional structural properties and conductivity, and are being incorporated into diverse manufacturing processes, yet little is known about the risks that these novel ..
  49. A nanotherapeutic approach to combat staphylococcal biofilm-associated infection
    Mark S Smeltzer; Fiscal Year: 2011
    ..we will generate antibodies to these proteins that can be used for the targeted delivery of gold-plated carbon nanotubes directly to the bacterial cell surface...
  50. Mechanisms of mast cell directed carbon nanotube toxicity
    JARED MICHAEL BROWN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Engineered nanomaterials, including carbon nanotubes (CNT), have unique physicochemical properties with potential to impact diverse aspects of society...
  51. Nanoparticle Effects on Epithelial Cell Protein Expression and Function
    Frank A Witzmann; Fiscal Year: 2012
    ..by applicant) Our hypothesis contends that manufactured carbon nanoparticles (fullerenes, single-walled nanotubes, and multi-walled nanotubes), when exposed to barrier epithelial (bronchiolar, intestinal, and kidney) cells, ..
  52. Toxicity and Efficacy of Gold Nanoparticle Photothermal Therapy in Cancer
    Dong M Shin; Fiscal Year: 2013
    ..This Au NR PTT has a great therapeutic potential to target locally advanced disease which has become resistant to conventional and standard treatment. ..
  53. Hybrid Organic-Inorganic Composite Materials for Bone Repairs
    ADEREMI R OKI; Fiscal Year: 2012
    ..b.Silane functionalized carbon nanotubes integrated with bioglass by sol-gel processing. c...
  54. Optoacoustic system for monitoring biodistribution of nanoparticles in vivo.
    Alexander A Oraevsky; Fiscal Year: 2011
    ..of using optoacoustic technology to perform quantitative biodistribution analysis of gold nanorods and carbon nanotubes in mice...
  55. In vivo molecular laser detection and treatment of circulating cancer stem cells
    Vladimir P Zharov; Fiscal Year: 2010
    ..and noninvasive laser photoacoustic (PA) techniques;2) biocompatible functionalized hybrid gold-magnetic nanotubes (GMNTs);and 3) laser photothermal (PT) elimination of stem CTCs...
  56. ELECTROSPINNING ARTIFICIAL LIGAMENTS AND TENDONS FOR POTENTIAL PROSTHESES
    JAVIER MACOSSAY-TORRES; Fiscal Year: 2011
    ..Furthermore, carbon nanotubes and carbon nanofibers will be incorporated into the EPN to enhance the mechanical properties of the assemblies ..
  57. Plasma Membrane Proteins in Myeloid-Derived Suppressor Cells
    Catherine C Fenselau; Fiscal Year: 2013
    ..isolation;elimination of gel electrophoresis with a chemical cleavage step;removal of bilayer lipids by magnetic nanotubes;and chemical and bioinformatic processing customized for mid-length peptides containing trans-membrane domains...
  58. Evaluation of Carbon Nanotube Electrodes for Neural Stimulation
    CHARLES BERNARD PARKER; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The goal of this project is to evaluate carbon nanotubes (CNTs) as lower impedance, smaller electrodes for neurostimulation, using deep brain stimulation (DBS) as a test case...
  59. Implantable multi-analyte sensors for the continuous monitoring of body chemistri
    NATALIE ANN WISNIEWSKI; Fiscal Year: 2013
    ....
  60. Nanoporous Drug Delivery Systems
    Sergei N Smirnov; Fiscal Year: 2013
    ..In particular, silica nanotubes and mesoporous silica nanoparticles hydrophobically modified inside and with multifunctional exterior ..
  61. Gadonanotubes as New MRI Nanolabels for Stem Cell Tracking
    EMERSON CARVALHO PERIN; Fiscal Year: 2010
    ..In the proposed project, we will evaluate a new approach for labeling stem cells with carbon nanotubes so they can be tracked by magnetic resonance imaging in a pig model of myocardial infarction.
  62. Force Sensing with Nanotubes
    Fred A Pereira; Fiscal Year: 2012
    ..This work will provide a basis to design force sensors for applications in nanotechnology. ..
  63. Array of Resistive Sensors for Detecting Lung Cancer in Exhaled Air
    KATHERINE ANDREA MIRICA; Fiscal Year: 2013
    ..Each component of an array comprises a bundle of carbon nanotubes-functionalized with receptors designed to capture a specific volatile analyte-positioned between two electrodes...
  64. Long-term Luminescence-based Glucose Monitoring
    NATALIE ANN WISNIEWSKI; Fiscal Year: 2013
    ..Clinical translation of this technology will motivate and enable diabetic patients to more tightly control their glucose levels without fear of hypoglycemia, and will reduce the diabetes disease burden on the healthcare system. ..
  65. RNA Nanomotor Based Active Devices for Biology and Medicine
    Rashid Bashir; Fiscal Year: 2009
    ..recent years, nanofabrication capabilities have progressed to a point where sub 20nm nanopores, nanowires, and nanotubes can be grown at specific locations on a silicon wafer such that these structures can possibly be interfaced with ..
  66. Cellular and Molecular Mechanisms of REM Sleep Control
    James Quattrochi; Fiscal Year: 2005
    ....
  67. Chitosan IFNgamma-pDNA Nanosphere Therapy and Immunopathology of Allergic Asthma
    Shyam Mohapatra; Fiscal Year: 2006
    ..It is anticipated that the results of these studies will contribute significantly to our knowledge of asthma and CIN therapy may provide a major breakthrough in management of asthma. ..
  68. Nanosphere-Antibiotic Corneal Contact Lens Delivery System
    CHARLES LEAHY; Fiscal Year: 2009
    ....
  69. Comparative In Vivo Biodistribution of Characterized Manufactured Nanomaterials
    Nancy A Monteiro Riviere; Fiscal Year: 2010
    ..between MNM and biological systems by conducting in vivo ADME studies of fullerenes and single walled carbon nanotubes (SWNT) in rats and pigs, along with intensive physicochemical characterizations and in vitro cell assays...
  70. Trimetallic Nitride Templated Endohedral Metallofullerenes as Dual Imaging and Mu
    MARISSA RYLANDER; Fiscal Year: 2009
    ..of the form Gd3N@C80 independently and in a peapod arrangement (Gd3N@C80 molecules within single- walled carbon nanotubes) denoted as Gd3N@C80-peapods in cancer laser induced hyperthermia therapy...
  71. Self-microencapsulation in polymer delivery systems without organic solvents
    Steven P Schwendeman; Fiscal Year: 2010
    ....
  72. Novel Nano-Constructs to Target and Destroy Tumor Neovasculature
    Michael McDevitt; Fiscal Year: 2009
    ..synthetic nanostructures will be designed as hybrid molecules consisting of biologics, radionuclides and carbon nanotubes and should have emergent anti-cancer properties...
  73. DEVELOPMENT OF DRUG DELIVERY SYSTEMS BASED ON NEW BIO-S*
    Ian McLennan; Fiscal Year: 2002
    ..These nanosphere particles could potentially extend the use of antitumor agents such as namtothecin derivatives, BCNU. ..