nanostructures

Summary

Summary: Nanometer-sized objects.

Top Publications

  1. ncbi Toxic potential of materials at the nanolevel
    Andre Nel
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 311:622-7. 2006
  2. ncbi Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods
    Xiaohua Huang
    Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Am Chem Soc 128:2115-20. 2006
  3. ncbi Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells
    B Devika Chithrani
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada
    Nano Lett 6:662-8. 2006
  4. ncbi Nanocarriers as an emerging platform for cancer therapy
    Dan Peer
    Department of Anesthesia, Immune Disease Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Nanotechnol 2:751-60. 2007
  5. pmc Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles
    Gunter Oberdorster
    Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
    Environ Health Perspect 113:823-39. 2005
  6. ncbi Understanding biophysicochemical interactions at the nano-bio interface
    Andre E Nel
    Division of NanoMedicine, David Geffen School of Medicine and California NanoSystems Institute at UCLA, Los Angeles, California 90095, USA
    Nat Mater 8:543-57. 2009
  7. ncbi Folding DNA to create nanoscale shapes and patterns
    Paul W K Rothemund
    Departments of Computer Science and Computation and Neural Systems, California Institute of Technology, Pasadena, California 91125, USA
    Nature 440:297-302. 2006
  8. ncbi PLGA-based nanoparticles: an overview of biomedical applications
    Fabienne Danhier
    Universite Catholique de Louvain, Louvain Drug Research Institute, Pharmaceutics and Drug Delivery, Avenue Mounier, B1 73 12, 1200 Brussels, Belgium
    J Control Release 161:505-22. 2012
  9. ncbi Nanoparticle therapeutics: an emerging treatment modality for cancer
    Mark E Davis
    Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    Nat Rev Drug Discov 7:771-82. 2008
  10. doi Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications
    Sophie Laurent
    Department of General, Organic, and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons Hainaut, B 7000 Mons, Belgium
    Chem Rev 108:2064-110. 2008

Detail Information

Publications397 found, 100 shown here

  1. ncbi Toxic potential of materials at the nanolevel
    Andre Nel
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 311:622-7. 2006
    ..The establishment of principles and test procedures to ensure safe manufacture and use of nanomaterials in the marketplace is urgently required and achievable...
  2. ncbi Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods
    Xiaohua Huang
    Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Am Chem Soc 128:2115-20. 2006
    ..Thus, both efficient cancer cell diagnostics and selective photothermal therapy are realized at the same time...
  3. ncbi Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells
    B Devika Chithrani
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada
    Nano Lett 6:662-8. 2006
    ..90, and 2.24 h, respectively). The findings from this study will have implications in the chemical design of nanostructures for biomedical applications (e.g...
  4. ncbi Nanocarriers as an emerging platform for cancer therapy
    Dan Peer
    Department of Anesthesia, Immune Disease Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Nanotechnol 2:751-60. 2007
    ..We detail the arsenal of nanocarriers and molecules available for selective tumour targeting, and emphasize the challenges in cancer treatment...
  5. pmc Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles
    Gunter Oberdorster
    Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
    Environ Health Perspect 113:823-39. 2005
    ..the basis for the expanding field of nanotoxicology, which can be defined as safety evaluation of engineered nanostructures and nanodevices...
  6. ncbi Understanding biophysicochemical interactions at the nano-bio interface
    Andre E Nel
    Division of NanoMedicine, David Geffen School of Medicine and California NanoSystems Institute at UCLA, Los Angeles, California 90095, USA
    Nat Mater 8:543-57. 2009
    ..This knowledge is important from the perspective of safe use of nanomaterials...
  7. ncbi Folding DNA to create nanoscale shapes and patterns
    Paul W K Rothemund
    Departments of Computer Science and Computation and Neural Systems, California Institute of Technology, Pasadena, California 91125, USA
    Nature 440:297-302. 2006
    ..properties of atoms and molecules to direct their self-organization, is widely used to make relatively simple nanostructures. A key goal for this approach is to create nanostructures of high complexity, matching that routinely achieved ..
  8. ncbi PLGA-based nanoparticles: an overview of biomedical applications
    Fabienne Danhier
    Universite Catholique de Louvain, Louvain Drug Research Institute, Pharmaceutics and Drug Delivery, Avenue Mounier, B1 73 12, 1200 Brussels, Belgium
    J Control Release 161:505-22. 2012
    ..This review focuses on the understanding of specific characteristics exploited by PLGA-based nanoparticles to target a specific organ or tissue or specific cells...
  9. ncbi Nanoparticle therapeutics: an emerging treatment modality for cancer
    Mark E Davis
    Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    Nat Rev Drug Discov 7:771-82. 2008
    ....
  10. doi Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications
    Sophie Laurent
    Department of General, Organic, and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons Hainaut, B 7000 Mons, Belgium
    Chem Rev 108:2064-110. 2008
  11. pmc Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
    Mark E Davis
    Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    Nature 464:1067-70. 2010
    ..Together, these data demonstrate that siRNA administered systemically to a human can produce a specific gene inhibition (reduction in mRNA and protein) by an RNAi mechanism of action...
  12. ncbi A logic-gated nanorobot for targeted transport of molecular payloads
    Shawn M Douglas
    Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02115, USA
    Science 335:831-4. 2012
    ..Our prototype could inspire new designs with different selectivities and biologically active payloads for cell-targeting tasks...
  13. pmc Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties
    Tian Xia
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, California 90095, USA
    ACS Nano 2:2121-34. 2008
    ....
  14. ncbi Size-dependent cytotoxicity of gold nanoparticles
    Yu Pan
    Biomedical Engineering, Biointerface Laboratory, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Small 3:1941-9. 2007
    ..The cellular response is size dependent, in that 1.4-nm particles cause predominantly rapid cell death by necrosis within 12 h while closely related particles 1.2 nm in diameter effect predominantly programmed cell death by apoptosis...
  15. pmc Delivering nanomedicine to solid tumors
    Rakesh K Jain
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
    Nat Rev Clin Oncol 7:653-64. 2010
    ..Finally, we discuss design considerations for optimizing the delivery of nanoparticles to tumors...
  16. doi Nanoparticle-mediated cellular response is size-dependent
    Wen Jiang
    Nat Nanotechnol 3:145-50. 2008
    b>Nanostructures of different sizes, shapes and material properties have many applications in biomedical imaging, clinical diagnostics and therapeutics...
  17. ncbi Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity
    Ellen E Connor
    Department of Basic Pharmaceutical Sciences, University of South Carolina, Columbia, SC 29208, USA
    Small 1:325-7. 2005
  18. ncbi Simultaneous phase and size control of upconversion nanocrystals through lanthanide doping
    Feng Wang
    Department of Chemistry, National University of Singapore, 117543, Singapore
    Nature 463:1061-5. 2010
    ....
  19. ncbi Upconversion nanophosphors for small-animal imaging
    Jing Zhou
    Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, PR China
    Chem Soc Rev 41:1323-49. 2012
    ..The biodistribution and toxicology of UCNPs are further described. Finally, we discuss the challenges and opportunities in the development of UCNP-based nanoplatforms for small-animal imaging (276 references)...
  20. ncbi Therapeutic nanoparticles for drug delivery in cancer
    Kwangjae Cho
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Clin Cancer Res 14:1310-6. 2008
    ..Multifunctional and multiplex nanoparticles are now being actively investigated and are on the horizon as the next generation of nanoparticles, facilitating personalized and tailored cancer treatment...
  21. ncbi Effect of surface properties on nanoparticle-cell interactions
    Ayush Verma
    Department of Materials Science and Engineering, Massachusetts Institute of Technology MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Small 6:12-21. 2010
    ..Challenges for undertaking a systematic study to elucidate nanoparticle-cell interactions are also discussed...
  22. pmc Challenges and opportunities for structural DNA nanotechnology
    Andre V Pinheiro
    Center for Single Molecule Biophysics, The Biodesign Institute, Arizona State University, Tempe, USA
    Nat Nanotechnol 6:763-72. 2011
    ..In particular, we highlight the potential use of DNA nanostructures in molecular and cellular biophysics, as biomimetic systems, in energy transfer and photonics, and in ..
  23. ncbi The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder
    Matthew J Dalby
    Centre for Cell Engineering, Joseph Black Building, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, UK
    Nat Mater 6:997-1003. 2007
    ..In addition, the current studies show that topographically treated MSCs have a distinct differentiation profile compared with those treated with osteogenic media, which has implications for cell therapies...
  24. ncbi Particle size-dependent organ distribution of gold nanoparticles after intravenous administration
    Wim H De Jong
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, Antonie van Leeuwenhoeklaan 9, Bilthoven, The Netherlands
    Biomaterials 29:1912-9. 2008
    ..The results demonstrate that tissue distribution of gold nanoparticles is size-dependent with the smallest 10nm nanoparticles showing the most widespread organ distribution...
  25. ncbi Graphene in mice: ultrahigh in vivo tumor uptake and efficient photothermal therapy
    Kai Yang
    Soft Materials Laboratory FUNSOM, Jiangsu Key Laboratory for Carbon Based Functional Materials and Devices, Institute of Functional Nano, Soochow University, Suzhou, Jiangsu 215123, China
    Nano Lett 10:3318-23. 2010
    ....
  26. pmc Endocytosis of nanomedicines
    Gaurav Sahay
    Department of Pharmaceutical Sciences and Center for Drug Delivery and Nanomedicine, College of Pharmacy, M V Lomonosov Moscow State University, 119899 Moscow, Russia
    J Control Release 145:182-95. 2010
    ..This review will be useful to a diverse audience of students and scientists who are interested in understanding endocytosis of nanomedicines...
  27. ncbi Endocytosis at the nanoscale
    Irene Canton
    The Krebs Institute, The Centre for Membrane Interaction and Dynamics, The Sheffield Cancer Research Centre, and the Department of Biomedical Science, The University of Sheffield, Western Bank, Sheffield, S10 2TN, UK
    Chem Soc Rev 41:2718-39. 2012
    ..Finally, we discuss different drug delivery strategies on how to evade lysosomal degradation to promote effective release of the cargo (376 references)...
  28. pmc Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo
    Omid C Farokhzad
    Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:6315-20. 2006
    ..Dtxl alone had a survivability of only 14%. Saline and nanoparticles without drug were similarly nonefficacious. This report demonstrates the potential utility of nanoparticle-aptamer bioconjugates for a therapeutic application...
  29. pmc Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts
    Martin Lundqvist
    Centre for BioNano Interactions, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland
    Proc Natl Acad Sci U S A 105:14265-70. 2008
    ..We comment on the future need for scientific understanding, characterization, and possibly some additional emphasis on standards for the surfaces of nanoparticles...
  30. ncbi Knocking down barriers: advances in siRNA delivery
    Kathryn A Whitehead
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Rev Drug Discov 8:129-38. 2009
    ..Here, we provide an update on the progress of RNAi therapeutics and highlight novel synthetic materials for the encapsulation and intracellular delivery of nucleic acids...
  31. pmc Self-assembly of DNA into nanoscale three-dimensional shapes
    Shawn M Douglas
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 459:414-8. 2009
    ..We demonstrate the design and assembly of nanostructures approximating six shapes-monolith, square nut, railed bridge, genie bottle, stacked cross, slotted cross-with ..
  32. ncbi Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm
    Tian Xia
    Division of Clinical Immunology and Allergy, Department of Medicine, University of California, Los Angeles, California 90095, USA
    Nano Lett 6:1794-807. 2006
    ..Although not all materials have electronic configurations or surface properties to allow spontaneous ROS generation, particle interactions with cellular components are capable of generating oxidative stress...
  33. ncbi Strategies in the design of nanoparticles for therapeutic applications
    Robby A Petros
    Department of Chemistry, University of North Texas, Denton, Texas 76203, USA
    Nat Rev Drug Discov 9:615-27. 2010
    ..This Review focuses on recent progress important for the rational design of such nanoparticles and discusses the challenges to realizing the potential of nanoparticles...
  34. ncbi Physical-chemical aspects of protein corona: relevance to in vitro and in vivo biological impacts of nanoparticles
    Marco P Monopoli
    Centre for BioNano Interactions, School of Chemistry and Chemical Biology, University College Dubli, Belfield, Dublin, Ireland
    J Am Chem Soc 133:2525-34. 2011
    ....
  35. ncbi Cytotoxicity of nanoparticles
    Nastassja Lewinski
    Department of Bioengineering MS 142, Rice University, PO Box 1892, Houston, TX 77251 1892, USA
    Small 4:26-49. 2008
    ....
  36. pmc Nanoparticle exposure at nanotechnology workplaces: a review
    Thomas Aj Kuhlbusch
    Air Quality and Sustainable Nanotechnology, Institute of Energy and Environmental Technology, Duisburg, Germany
    Part Fibre Toxicol 8:22. 2011
    ..In both cases, whether workplace measurements or laboratories studies, the issue of background particles is a major problem. From this review, major areas for future activities and focal points are identified...
  37. ncbi Nanosize and vitality: TiO2 nanotube diameter directs cell fate
    Jung Park
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, Germany
    Nano Lett 7:1686-91. 2007
    ..Thus, on a TiO2 nanotube surface, a lateral spacing geometry with openings of 30-50 nm represents a critical borderline for cell fate...
  38. pmc Factors affecting the clearance and biodistribution of polymeric nanoparticles
    Frank Alexis
    Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Pharm 5:505-15. 2008
    ....
  39. ncbi Recent advances on chitosan-based micro- and nanoparticles in drug delivery
    Sunil A Agnihotri
    Drug Delivery Division, Center of Excellence in Polymer Science, Karnatak University, Dharwad 580 003, India
    J Control Release 100:5-28. 2004
    ..Hence, the present review is timely...
  40. pmc Drug delivery and nanoparticles:applications and hazards
    Wim H De Jong
    Laboratory for Toxicology, Pathology and Genetics, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Int J Nanomedicine 3:133-49. 2008
    ..So, probably additional more specific testing would be needed...
  41. pmc Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli
    Sukdeb Pal
    Research Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul 151 742, South Korea
    Appl Environ Microbiol 73:1712-20. 2007
    ..coli...
  42. ncbi Impact of nanotechnology on drug delivery
    Omid C Farokhzad
    Laboratory of Nanomedicine and Biomaterials and Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    ACS Nano 3:16-20. 2009
    ..Herein, we focus on the application of nanotechnology to drug delivery and highlight several areas of opportunity where current and emerging nanotechnologies could enable entirely novel classes of therapeutics...
  43. pmc Synthetic lipid membrane channels formed by designed DNA nanostructures
    Martin Langecker
    Lehrstuhl für Bioelektronik, Physics Department and ZNN WSI, Technische Universitat Munchen, 85748 Garching, Germany
    Science 338:932-6. 2012
    We created nanometer-scale transmembrane channels in lipid bilayers by means of self-assembled DNA-based nanostructures. Scaffolded DNA origami was used to create a stem that penetrated and spanned a lipid membrane, as well as a barrel-..
  44. ncbi Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
    Donald E Owens
    Department of Chemical Engineering, University of Texas at Austin, 1 University Station, C0400, Austin, TX 78712, USA
    Int J Pharm 307:93-102. 2006
    ..This method creates a hydrophilic protective layer around the nanoparticles that is able to repel the absorption of opsonin proteins via steric repulsion forces, thereby blocking and delaying the first step in the opsonization process...
  45. ncbi Albumin-based nanoparticles as potential controlled release drug delivery systems
    Ahmed O Elzoghby
    Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, El Khartoum Square, Azarita, Alexandria 21521, Egypt
    J Control Release 157:168-82. 2012
    ..Nanocomplexes of albumin with other components in the area of drug delivery are also included in this review...
  46. ncbi Quantitative assessment of the comparative nanoparticle-uptake efficiency of a range of cell lines
    Tiago Dos Santos
    Centre for BioNano Interactions, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland
    Small 7:3341-9. 2011
    ..These conclusions have important implications for the assessment of the safety of nanomaterials and for the potential biomedical applications of nanoparticles...
  47. ncbi Nanoparticles: a review of particle toxicology following inhalation exposure
    Shahnaz Bakand
    School of Chemistry, The University of New South Wales, Sydney, Australia
    Inhal Toxicol 24:125-35. 2012
    ..Current advances and limitations of toxicity assessment methods of nanoparticles are discussed highlighting the recent improvements of in vitro screening tools for the safety evaluation of the rapidly expanding area of nanotechnology...
  48. pmc Selenium nanoparticles inhibit Staphylococcus aureus growth
    Phong A Tran
    Physics Department, Brown University, Providence, RI, USA
    Int J Nanomedicine 6:1553-8. 2011
    ..Therefore, this study suggests that selenium nanoparticles may be used to effectively prevent and treat S. aureus infections and thus should be further studied for such applications...
  49. ncbi Upconversion nanoparticles in biological labeling, imaging, and therapy
    Feng Wang
    Department of Chemistry, Faculty of Science, National University of Singapore, 3 Science Drive 3, Singapore 117543
    Analyst 135:1839-54. 2010
    ....
  50. ncbi Curcumin and its nano-formulation: the kinetics of tissue distribution and blood-brain barrier penetration
    Yin Meng Tsai
    Institute of Traditional Medicine, National Yang Ming University, Taipei, Taiwan
    Int J Pharm 416:331-8. 2011
    ..These findings provide further understanding for the possible therapeutic effects of curcumin and C-NPs in further pre-clinical and clinical research...
  51. ncbi Dynamic DNA nanotechnology using strand-displacement reactions
    David Yu Zhang
    Wyss Institute for Biologically Inspired Engineering, Harvard University, 3 Blackfan Circle, Room 530, Boston, Massachussetts 02115, USA
    Nat Chem 3:103-13. 2011
    ..This has enabled the construction of a diverse and rapidly growing set of DNA nanostructures and nanodevices through the programmed hybridization of complementary strands...
  52. pmc PEGylated nanographene oxide for delivery of water-insoluble cancer drugs
    Zhuang Liu
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    J Am Chem Soc 130:10876-7. 2008
    ..Our results showed that graphene is a novel class of material promising for biological applications including future in vivo cancer treatment with various aromatic, low-solubility drugs...
  53. ncbi Immunological properties of engineered nanomaterials
    Marina A Dobrovolskaia
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick, NCI Frederick, 1050 Boyles St, Bldg 469, Frederick, Maryland 21702, USA
    Nat Nanotechnol 2:469-78. 2007
    ..Modifying these factors can significantly reduce the immunotoxicity of nanoparticles and make them useful platforms for drug delivery...
  54. ncbi Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen species
    C Carlson
    Applied Biotechnology Branch, Human Effectiveness Directorate, Wright Patterson Air Force Base, Dayton, Ohio 45433, USA
    J Phys Chem B 112:13608-19. 2008
    ..In summary, a size-dependent toxicity was produced by silver nanoparticles, and one predominant mechanism of toxicity was found to be largely mediated through oxidative stress...
  55. pmc Targeting of drugs and nanoparticles to tumors
    Erkki Ruoslahti
    Vascular Mapping Center, Sanford Burnham Medical Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA
    J Cell Biol 188:759-68. 2010
    ..We review the recent advances in this delivery approach with a focus on the use of molecular markers of tumor vasculature as the primary target and nanoparticles as the delivery vehicle...
  56. ncbi Toxicity of silver nanoparticles to Chlamydomonas reinhardtii
    Enrique Navarro
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, Dubendorf, Switzerland
    Environ Sci Technol 42:8959-64. 2008
    ..Together, the results indicate that the interaction of these particles with algae influences the toxicity of AgNP, which is mediated by Ag+. Particles contributed to the toxicity as a source of Ag+ which is formed in presence of algae...
  57. ncbi In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags
    Ximei Qian
    Departments of Biomedical Engineering and Chemistry, Emory University and Georgia Institute of Technology, 101 Woodruff Circle, Suite 2001, Atlanta, Georgia 30322, USA
    Nat Biotechnol 26:83-90. 2008
    ....
  58. pmc Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β
    Amir S Yazdi
    Department of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    Proc Natl Acad Sci U S A 107:19449-54. 2010
    ..The current use of nano-TiO(2) may present a health hazard due to its capacity to induce IL-1R signaling, a situation reminiscent of inflammation provoked by asbestos exposure...
  59. ncbi Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles
    Chunbai He
    State Key Laboratory of Genetic Engineering, Department of Pharmaceutical Sciences, School of Life Sciences, Fudan University, Shanghai 200433, China
    Biomaterials 31:3657-66. 2010
    ..These results could serve as a guideline in the rational design of drug nanocarriers with maximized therapeutic efficacy and predictable in vivo properties, in which the control of particle size and surface charge was of significance...
  60. pmc Engineering substrate topography at the micro- and nanoscale to control cell function
    Christopher J Bettinger
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Angew Chem Int Ed Engl 48:5406-15. 2009
    ..Future challenges and opportunities in cell-nanotopography engineering are also discussed, including the elucidation of mechanisms and applications in tissue engineering...
  61. ncbi Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer
    William J Gradishar
    Northwestern University, Breast Oncology, Division of Hematology Oncology, Department of Medicine, Chicago, IL 60611, USA
    J Clin Oncol 23:7794-803. 2005
    ..This phase III study was performed to confirm preclinical studies demonstrating superior efficacy and reduced toxicity of ABI-007 compared with standard paclitaxel...
  62. ncbi A review of the in vivo and in vitro toxicity of silver and gold particulates: particle attributes and biological mechanisms responsible for the observed toxicity
    Helinor J Johnston
    Centre for Nano Safety, School of Life Sciences, Edinburgh Napier University, Edinburgh, UK
    Crit Rev Toxicol 40:328-46. 2010
    ..Alternatively, a combination of both may be responsible, as the release of ions would be expected to be greater for smaller particles...
  63. ncbi Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology
    G Oberdorster
    Department of Environmental Medicine, University of Rochester, 601 Elmwood Avenue, Medical Center, Rochester, NY 14642, USA
    J Intern Med 267:89-105. 2010
    ....
  64. pmc Programming the magnitude and persistence of antibody responses with innate immunity
    Sudhir Pai Kasturi
    Emory Vaccine Center, Emory University, Atlanta, Georgia 30329, USA
    Nature 470:543-7. 2011
    ..Immunization protected completely against lethal avian and swine influenza virus strains in mice, and induced robust immunity against pandemic H1N1 influenza in rhesus macaques...
  65. ncbi The relationship between the nanostructure of titanium surfaces and bacterial attachment
    Sabrina D Puckett
    Division of Engineering and Department of Orthopaedics, Brown University, Providence, RI 02917, USA
    Biomaterials 31:706-13. 2010
    ....
  66. pmc In vitro cytotoxicity of nanoparticles in mammalian germline stem cells
    Laura Braydich-Stolle
    Department of Biology, The University of Dayton, OH 45469, USA
    Toxicol Sci 88:412-9. 2005
    ..Our results suggest that this cell line provides a valuable model with which to assess the cytotoxicity of nanoparticles in the germ line in vitro...
  67. ncbi Metal oxide hollow nanostructures for lithium-ion batteries
    Zhiyu Wang
    School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore
    Adv Mater 24:1903-11. 2012
    ..In this Research News, we summarize the recent research activities in the synthesis of metal oxide hollow nanostructures with controlled shape, size,composition, and structural complexity, as well as their applications in LIBs...
  68. pmc Translocation of inhaled ultrafine manganese oxide particles to the central nervous system
    Alison Elder
    Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
    Environ Health Perspect 114:1172-8. 2006
    ..Studies in monkeys with intranasally instilled gold ultrafine particles (UFPs; <100 nm) and in rats with inhaled carbon UFPs suggested that solid UFPs deposited in the nose travel along the olfactory nerve to the olfactory bulb...
  69. ncbi Nanomaterials in the environment: behavior, fate, bioavailability, and effects
    Stephen J Klaine
    Institute of Environmental Toxicology, Department of Biology, Clemson University, P O Box 709 Pendleton, South Carolina 29672, USA
    Environ Toxicol Chem 27:1825-51. 2008
    ..The need for standard reference and testing materials as well as methodology for suspension preparation and testing is also discussed...
  70. ncbi Nanoparticles in medicine: therapeutic applications and developments
    L Zhang
    Department of Chemical Engineering and Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Clin Pharmacol Ther 83:761-9. 2008
    ..These properties can be used to overcome some of the limitations found in traditional therapeutic and diagnostic agents...
  71. ncbi Immunotargeted nanoshells for integrated cancer imaging and therapy
    Christopher Loo
    Department of Bioengineering, Rice University, P O Box 1892, Houston, Texas 77251 1892, USA
    Nano Lett 5:709-11. 2005
    ..In a proof of principle experiment, dual imaging/therapy immunotargeted nanoshells are used to detect and destroy breast carcinoma cells that overexpress HER2, a clinically relevant cancer biomarker...
  72. ncbi Toxicity of nanomaterials
    Shahriar Sharifi
    Department of Biomedical Engineering, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Chem Soc Rev 41:2323-43. 2012
    ..This critical review discusses the biophysicochemical properties of various nanomaterials with emphasis on currently available toxicology data and methodologies for evaluating nanoparticle toxicity (286 references)...
  73. ncbi Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2)
    Vyom Sharma
    Nanomaterial Toxicology Group, CSIR Indian Institute of Toxicology Research, Mahatma Gandhi Marg, P O Box 80, Lucknow, 226001, Uttar Pradesh, India
    Apoptosis 17:852-70. 2012
    ..This study investigating the effects of ZnO nanoparticles in human liver cells has provided valuable insights into the mechanism of toxicity induced by ZnO nanoparticles...
  74. pmc Current advances in research and clinical applications of PLGA-based nanotechnology
    Jian ming Lu
    Michael E DeBakey Department of Surgery, Division of Vascular Surgery and Endovascular Therapy, Baylor College of Medicine, Houston, TX 77030, USA
    Expert Rev Mol Diagn 9:325-41. 2009
    ....
  75. pmc Surface-charge-dependent cell localization and cytotoxicity of cerium oxide nanoparticles
    Atul Asati
    NanoScience Technology Center, Suite 400, 12424 Research Parkway, Orlando, Florida 32826, USA
    ACS Nano 4:5321-31. 2010
    ..Taken together, these results indicate that the differential surface-charge-dependent localization of nanoceria in normal and cancer cells plays a critical role in the nanoparticles' toxicity profile...
  76. pmc Engineered design of mesoporous silica nanoparticles to deliver doxorubicin and P-glycoprotein siRNA to overcome drug resistance in a cancer cell line
    Huan Meng
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, California 90095, USA
    ACS Nano 4:4539-50. 2010
    ..These results demonstrate that it is possible to use the MSNP platform to effectively deliver a siRNA that knocks down gene expression of a drug exporter that can be used to improve drug sensitivity to a chemotherapeutic agent...
  77. pmc Near-infrared fluorescent nanoprobes for cancer molecular imaging: status and challenges
    Xiaoxiao He
    Molecular Imaging Program at Stanford MIPS, Department of Radiology, Bio X Program and Stanford Cancer Center, Stanford University School of Medicine, Stanford, CA 94305, USA
    Trends Mol Med 16:574-83. 2010
    ....
  78. ncbi Nanostructures in biodiagnostics
    Nathaniel L Rosi
    Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208 3113, USA
    Chem Rev 105:1547-62. 2005
  79. ncbi Silver nanoparticles as a new generation of antimicrobials
    Mahendra Rai
    Department of Biotechnology, SGB Amravati University, Amravati 444 602, Maharashtra, India
    Biotechnol Adv 27:76-83. 2009
    ..Hence, silver nanoparticles have emerged up with diverse medical applications ranging from silver based dressings, silver coated medicinal devices, such as nanogels, nanolotions, etc...
  80. ncbi Oligonucleotide-modified gold nanoparticles for intracellular gene regulation
    Nathaniel L Rosi
    Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 3113 USA
    Science 312:1027-30. 2006
    ..By chemically tailoring the density of DNA bound to the surface of gold nanoparticles, we demonstrated a tunable gene knockdown...
  81. ncbi Nanoparticle and targeted systems for cancer therapy
    Lisa Brannon-Peppas
    Department of Biomedical Engineering, The University of Texas at Austin, 1 University Station, C0800, Austin, TX 78712 0231, USA
    Adv Drug Deliv Rev 56:1649-59. 2004
    ..Delivery methods that specifically use nanoparticles are also highlighted, including both degradable and nondegradable polymers...
  82. ncbi In vitro toxicity of nanoparticles in BRL 3A rat liver cells
    S M Hussain
    Applied Biotechnology, Air Force Research Laboratory HEPB, Wright Patterson AFB, OH, USA
    Toxicol In Vitro 19:975-83. 2005
    ....
  83. ncbi Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging
    Jae Hyun Lee
    Department of Chemistry and Nanomedical National Core Research Center, Yonsei University, Seoul 120 749, Korea
    Nat Med 13:95-9. 2007
    ..Also, we successfully visualized small tumors implanted in a mouse. Such high-performance, nanotechnology-based molecular probes could enhance the ability to visualize other biological events critical to diagnostics and therapeutics...
  84. pmc Biodegradable luminescent porous silicon nanoparticles for in vivo applications
    Ji Ho Park
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA
    Nat Mater 8:331-6. 2009
    ..These results demonstrate a new type of multifunctional nanostructure with a low-toxicity degradation pathway for in vivo applications...
  85. ncbi In vitro cytotoxicity of oxide nanoparticles: comparison to asbestos, silica, and the effect of particle solubility
    Tobias J Brunner
    Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, CH 8093 Zurich, Switzerland
    Environ Sci Technol 40:4374-81. 2006
    ..While in vitro experiments may never replace in vivo studies, the relatively simple cytotoxic tests provide a readily available pre-screening method...
  86. ncbi Self-assembly of a nanoscale DNA box with a controllable lid
    Ebbe S Andersen
    Danish National Research Foundation Centre for DNA Nanotechnology
    Nature 459:73-6. 2009
    ..structural motifs and self-recognition properties of DNA can be exploited to generate self-assembling DNA nanostructures of specific shapes using a 'bottom-up' approach...
  87. ncbi Cytotoxicity of nanoparticles independent from oxidative stress
    Eleonore Fröhlich
    Center for Medical Research, Medical University of Graz, A 8010 Graz, Austria
    J Toxicol Sci 34:363-75. 2009
    ..The mechanism of this damage includes apoptosis, necrosis and inhibition of proliferation...
  88. ncbi Targeting of porous hybrid silica nanoparticles to cancer cells
    Jessica M Rosenholm
    Center for Functional Materials, Department of Physical Chemistry, Abo Akademi University, Porthansgatan 3 5, FI 2500 Turku, Finland
    ACS Nano 3:197-206. 2009
    ..In addition, the biospecifically tagged hybrid PEI-silica particles were shown to be noncytotoxic and able to specifically target folate receptor-expressing cancer cells also under coculture conditions...
  89. ncbi Particle surface characteristics may play an important role in phytotoxicity of alumina nanoparticles
    Ling Yang
    York Center for Environmental Engineering and Science, Department of Chemistry and Environmental Science, New Jersey Institute of Technology, University Heights, Newark, NJ 07102, USA
    Toxicol Lett 158:122-32. 2005
    ..5% and 1.0%), the non-loaded particles also showed decreased inhibition of root elongations. We supposed that the surface characteristics of the particles play an important role in the phytotoxicity of alumina nanoparticles...
  90. ncbi Nanomedicine: current status and future prospects
    S Moein Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Brighton, UK
    FASEB J 19:311-30. 2005
    ..Potential pitfalls or side effects associated with nanoparticles are also discussed...
  91. ncbi Differential uptake of functionalized polystyrene nanoparticles by human macrophages and a monocytic cell line
    Oleg Lunov
    Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, Ulm, Germany
    ACS Nano 5:1657-69. 2011
    ....
  92. ncbi Elemental selenium at nano size (Nano-Se) as a potential chemopreventive agent with reduced risk of selenium toxicity: comparison with se-methylselenocysteine in mice
    Jinsong Zhang
    University of Science and Technology of China, Hefei 230052, Anhui, P R China
    Toxicol Sci 101:22-31. 2008
    ..Our results suggest that Nano-Se can serve as a potential chemopreventive agent with reduced risk of Se toxicity...
  93. pmc Recent advances of chitosan nanoparticles as drug carriers
    Jun Jie Wang
    Research Center for Biomedicine and Health, Hangzhou Normal University, Hangzhou, Zhejiang, People s Republic of China
    Int J Nanomedicine 6:765-74. 2011
    ..This paper reviews published research on chitosan nanoparticles, including its preparation methods, characteristics, modification, in vivo metabolic processes, and applications...
  94. ncbi Application of nanotechnology in cancer therapy and imaging
    Xu Wang
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA
    CA Cancer J Clin 58:97-110. 2008
    ..Therefore, their application as cancer cell-specific delivery vehicles will be a significant addition to the currently available armory for cancer therapeutics and imaging...
  95. ncbi Thiolated chitosan nanoparticles as an oral delivery system for Amikacin: in vitro and ex vivo evaluations
    F Atyabi
    Novel Drug Delivery Systems Lab, Faculty of Pharmacy, Medical Sciences University of Tehran, Tehran 14155 6451, Iran
    J Nanosci Nanotechnol 9:4593-603. 2009
    ..Microbiological tests were carried out on two microorganisms; Pseudomona aeruginosa and Staphylococcus aureus to further confirm the amount of Amikacin inside drug loaded nanoparticles...
  96. ncbi Micellar nanocarriers: pharmaceutical perspectives
    V P Torchilin
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Mugar Building, Room 312, 360 Huntington Avenue, Boston, Massachusetts 02115, USA
    Pharm Res 24:1-16. 2007
    ..This review will discuss some recent trends in using micelles as pharmaceutical carriers...
  97. pmc Thiolated chitosan nanoparticles for enhancing oral absorption of docetaxel: preparation, in vitro and ex vivo evaluation
    Shahrooz Saremi
    Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    Int J Nanomedicine 6:119-28. 2011
    ..It can be concluded that by combining the advantages of both thiolated polymers and colloidal particles, these nanoparticles can be proposed as a drug carrier system for mucosal delivery of hydrophobic drugs...
  98. ncbi Close encounters of the small kind: adverse effects of man-made materials interfacing with the nano-cosmos of biological systems
    Anna A Shvedova
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, West Virginia University, Morgantown, USA
    Annu Rev Pharmacol Toxicol 50:63-88. 2010
    ..and may be viewed as the study of the undesirable interference between man-made nanomaterials and cellular nanostructures or nanomachines...
  99. pmc The emerging field of RNA nanotechnology
    Peixuan Guo
    Nanobiomedical Center, College of Engineering and College of Medicine, University of Cincinnati, Cincinnati, Ohio 45221, USA
    Nat Nanotechnol 5:833-42. 2010
    Like DNA, RNA can be designed and manipulated to produce a variety of different nanostructures. Moreover, RNA has a flexible structure and possesses catalytic functions that are similar to proteins...
  100. ncbi Oxidative stress, calcium homeostasis, and altered gene expression in human lung epithelial cells exposed to ZnO nanoparticles
    Chuan Chin Huang
    Department of Biological Sciences, Missouri University of Science and Technology, 105 Schrenk Hall, Rolla, MO 65409, USA
    Toxicol In Vitro 24:45-55. 2010
    ..5-fold. Thus, ZnO alters transcriptional regulation in BEAS-2B cells...
  101. ncbi The kinetics of the tissue distribution of silver nanoparticles of different sizes
    D P K Lankveld
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Biomaterials 31:8350-61. 2010
    ..Model parameter values were estimated by fitting to data. No clear relation between parameter values and corresponding particle diameters became apparent...

Research Grants79

  1. COMBINATORIAL-DESIGNED NANO-PLATFORMS TO OVERCOME TUMOR DRUG RESISTANCE
    Zhenfeng Duan; Fiscal Year: 2013
    ..growth factor receptor (EGFR)- targeting peptide for combinatorial self-assembly in aqueous media into nanostructures that can encapsulate siRNA duplexes, paclitaxel, and doxorubicin;(2) high-throughput evaluation of cellular ..
  2. Low Cost Diagnosis of Disease using Synthetic DNA Reactions
    William L Hughes; Fiscal Year: 2013
    ..A systematic transition will occur from the synthesis, discovery, and characterization of zinc oxide nanostructures for piezoelectric applications towards DNA-based nanotechnology for medical benefit...
  3. Multifunctional Printed Scaffolds for Enhancing Hepatocyte Viability and Function
    Ramille N Shah; Fiscal Year: 2013
    ..and with two years of post-doctoral research involving the investigation of self-assembling peptide amphiphile nanostructures for regenerative medicine at Northwestern University's Institute for BioNanotechnology in Medicine...
  4. BIOSENSOR ARRAYS BASED ON SINGLE WALL CARBON NANOTUBES
    James F Rusling; Fiscal Year: 2010
    ..These high surface area, patternable, conductive nanostructures provide new opportunities for highly sensitive biosensor arrays...
  5. Application of Carbon Nanotubes for Macrophage Activation in Brain Tumor Models
    Behnam Badie; Fiscal Year: 2010
    ..One example is carbon nanotubes (CNT), which are unique nanostructures with remarkable electronic and mechanical properties...
  6. Molecularly guided multimodal theranostics for breast cancer
    Amit Joshi; Fiscal Year: 2013
    ..Alternative cancer nanotherapeutics based on the photothermal response of gold nanostructures designed to absorb near-infrared (NIR), tissue-penetrating light has exhibited near 100% efficacy in the ..
  7. Plasmon-Controlled Fluorescence and Cardiac Markers
    Joseph R Lakowicz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): We propose to continue our studies on the development of metallic nanostructures for rapid high-sensitivity diagnostics, and in particular arrays for cardiac markers without amplifications steps...
  8. Bio-imaging with Isothermal DNA Self-Assembly
    David Yu Zhang; Fiscal Year: 2013
    ..In this proposal, DNA and RNA nanostructures and nanodevices that assemble and operate isothermally are presented and tested as bio-imaging tools...
  9. Bio-imaging with Isothermal DNA Self-Assembly
    David Yu Zhang; Fiscal Year: 2013
    ..In this proposal, DNA and RNA nanostructures and nanodevices that assemble and operate isothermally are presented and tested as bio-imaging tools...
  10. Use of Silver Nanostructures on Microtransponders in Ultra-sensitive Assay
    Wlodek Mandecki; Fiscal Year: 2011
    ..the sensitivity of microtransponder-based multiplexed bioassays by (1) introducing a coating with silver nanostructures onto the microtransponders (MTPs) to enhance fluorescence emission, and (2) improving the sensitivity of ..
  11. Enzyme-Responsive Nanoemulsions as Tumor-Specific Ultrasound Contrast Agents for
    Andrew P Goodwin; Fiscal Year: 2011
    ..Hongjie Dai, where he functionalized carbon nanotubes and gold nanostructures with new synthetic biocompatible assemblies to create novel hybrid nanostructures with enhanced photophysical ..
  12. Enzyme-Responsive Nanoemulsions as Tumor-Specific Ultrasound Contrast Agents
    Andrew P Goodwin; Fiscal Year: 2013
    ..Hongjie Dai, where he functionalized carbon nanotubes and gold nanostructures with new synthetic biocompatible assemblies to create novel hybrid nanostructures with enhanced photophysical ..
  13. Sub-Wavelength Imaging of Intracellular Metal Ions
    Joseph R Lakowicz; Fiscal Year: 2010
    ..is based on the emerging fields of plasmonic and nano-optics, on the novel optical properties of metallic nanostructures. It is known that sub- wavelength size electric field distributions can occur upon illumination of certain ..
  14. How do Nanoparticles Target Cancer? An In Vivo Experimental/Mathematical Study
    Bryan Ronain Smith; Fiscal Year: 2012
    ..e., personalization of medicine via customized nanostructures). Moreover, the optimal times for imaging or therapy with the selected NPs could be predicted...
  15. Flowcell for Biological Imaging with LiquidSTEM
    John Damiano; Fiscal Year: 2013
    ..Finally, we will, for the first time, characterize a wide variety of functionalized nanostructures intended for in vivo applications in their native environment and at atomic resolution.
  16. DNA Nanotags: Bright Fluorescent Labels and Sensors for Intracellular Imaging
    Bruce A Armitage; Fiscal Year: 2011
    ..intercalating dyes for the detection of DNA as well as more recent work in the design and synthesis of DNA nanostructures. The high brightness of the nanotags derives from their very large effective extinction coefficients due to ..
  17. Supporting RNAstructure: Software for RNA Analysis
    David H Mathews; Fiscal Year: 2013
    ..RNA function and to harness the power of RNA, with RNA interference, therapeutic RNA enzymes, or RNA nanostructures, an understanding of RNA structure is required...
  18. Nanofiber Scaffolds with Gradations in Mineral Content for Rotator Cuff Repair
    Younan Xia; Fiscal Year: 2013
    ..Our goal is to design, fabricate, and validate novel nanostructures for use in the surgical repair of rotator cuff tears to restore the torn tendon to its bony insertion...
  19. Center of Cancer Nanotechnology Excellence Focused on Therapy Response
    Sanjiv S Gambhir; Fiscal Year: 2010
    ..Cores provide a nanocharacterization laboratory resource;service for fabricated nanostructures;and an informatics and biostatistics resource...
  20. Nanoscale tools for functional studies of cancer-relevant chromatin modifications
    Carlos E Castro; Fiscal Year: 2013
    ..Specifically, we will develop 1) DNA origami nanostructures with multiple antibodies that recognize distinct physiological and cancer-relevant combinations of chromatin ..
  21. New Stereoregular Functionalized Fullerenes as Nanomedicines for PDT
    Long Y Chiang; Fiscal Year: 2012
    ..of this application is to (I) design and synthesize photoresponsive [60]fullerenyl enantiomers and related nanostructures as photosensitizers for PDT applications and (ii) carry out in vitro and in vivo biostudies of amphiphilic ..
  22. Chemically Controlled Assembly of Therapuetic Protein Nanostrctures
    Carston R Wagner; Fiscal Year: 2010
    ..cancer tissues, monoclonal and recombinant antibodies could be harnessed as recognition ligands for anticancer nanostructures. The targeting of radionuclides to tumors by conjugation to antibodies has been shown to be a successful ..
  23. Super-resolution Workstation for Imaging Live Biological Nanostructure
    Peter Saggau; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Super-resolution Workstation for Imaging Live Biological Nanostructures. A novel research instrument will be developed for visualizing and measuring living biological structures that are below the ..
  24. Self Assembling High Affinity Peptides for Point of Care Drug-Device Combinations
    SHRIKUMAR AMBUJAKSHAN NAIR; Fiscal Year: 2010
    ..of the lead parent metal-binding and vancomycin-binding peptides, which appear to assemble into higher-order nanostructures. SAPs enhance vancomycin loading on metal by 20-fold relative to IFBMs...
  25. Biomimetic Systems for Studying Nanoscale Structure Formation in Cell Membranes
    Noah Malmstadt; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Lipid nanostructures in cell membranes help control how cells interact with their environments and are therefore central actors in ..
  26. A Thermo-responsive Biopharmaceutical to Enhance the Tear Production of Lacritin
    Sandeep Samudre; Fiscal Year: 2013
    ..properties that promote phase separation, recombinant expression, protein purification, and self-assembly of nanostructures. ELPs are repeated pentameric peptides, (VPGXG)n, that have characteristic inverse phase transition ..
  27. Synthesis and Evaluation of Antibacterial Anionic Dendritic Amphiphiles
    ERIC LAWRENCE DANE; Fiscal Year: 2013
    ..2) Characterize the supramolecular nanostructures formed by the anionic dendritic amphiphiles...
  28. Genetic and Chemically Programmed Nanoparticles for Prodrug Therapy
    M G Finn; Fiscal Year: 2013
    ..provided by applicant): Virus-like particles (VLPs) represent the best-characterized and most easily tailored nanostructures for the targeting of disease...
  29. Optically Patterned DNA Prism
    Kevin D Dorfman; Fiscal Year: 2012
    ..To accomplish these goals, an optical patterning method will be used to fabricate nanostructures in photoresist, the nanostructures will be integrated into a microchannel that provides a pulsed electric ..
  30. Aggregation Properties of Hemopressin
    Surendra Kumar Nayak; Fiscal Year: 2013
    ..hemopressin's effects in biological assays is due to the tendency of this peptide to form self-assembled nanostructures in solution under physiologically relevant conditions...
  31. Nanotechnology Strategies for Growth of Bones and Teeth
    Samuel I Stupp; Fiscal Year: 2013
    ..developmental biology, we propose the development of highly bioactive materials containing bottom up designed nanostructures with potential to effectively regenerate bone and tooth enamel...
  32. Direct real-time single molecule DNA sequencing
    Xiaohua Huang; Fiscal Year: 2012
    ..Unlike the difficult to engineer man-made nanostructures of nanopore sequencing used to distinguish the 4 base types in close proximity and constant fluctuation, DNA ..
  33. Cell-and Nucleus-Permeable Luminescent Gold Nanoparticles
    Jie Zheng; Fiscal Year: 2010
    ..these aims will greatly advance our understanding of fundamental principles that regulate the permeability of nanostructures at the molecular level...
  34. Nanostructured in vitro TB latency model
    Graham S Timmins; Fiscal Year: 2010
    ..Recent publications demonstrate a unique phenomenon of cell-directed assembly of hybrid lipid-inorganic nanostructures that drive a unique non-replicative persistence, and protect bacteria and drastically prolong viability...
  35. DNA sequencing using nanopore-nanoelectrode devices for sensing and manipulation
    Marija Drndic; Fiscal Year: 2010
    ..demonstrate that the precise integration of solid-state nanopores with nanoelectrodes, nanochannels and other nanostructures will address key obstacles that must be overcome to achieve nanopore-based low-cost high-speed sequencing of ..
  36. Design of Therapeutic Peptide-Based Nanoparticles
    Vadim V Gaponenko; Fiscal Year: 2013
    ..certain peptides exhibit a distinct beta-hairpin conformation that allows them to assemble into spherical nanostructures. Nanostructures encounter a hydrophobic environment of the plasma membrane, disassemble, insert into the ..
  37. A New Dimension in Renal Clearance Design Criteria for Dendrimer Nanostructures
    Erik C Wiener; Fiscal Year: 2010
    ..is to add a new dimension to our understanding of the design criteria for renal clearance of dendrimer based nanostructures. We achieve this by gaining an understanding of how surface charge (SC) on dendrimers can be used to tune ..
  38. Shrink Induced Manufacturing Platform for Low-Cost Diagnostics (SIMPL-CD)
    Michelle Khine; Fiscal Year: 2013
    ..laser diode and photo-detector for <$100) with disposable robust plastic chips (with integrated metallic nanostructures for surface enhanced sensing) that can be manufactured for less than $0...
  39. Nanotubes in tumor imaging and therapy
    Suzy V Torti; Fiscal Year: 2011
    ..In this application we fabricate new nanostructures, test their anti-cancer efficacy in tissue culture and mouse models, and use mathematical modeling to optimize ..
  40. NIH Director's Pioneer Award
    Younan Xia; Fiscal Year: 2010
    b>Nanostructures have received extensive attention for their promising applications in electronics, photonics, and information storage. I believe these minuscule structures also hold great potential for advancing biomedical research...
  41. An Improved Atomic Force Microscope for Biomedical Applications: Deep AFM for lar
    Paul K Hansma; Fiscal Year: 2013
    ..The Atomic Force Microscope, AFM, with its ability to both image and manipulate nanostructures, has been a powerful tool in this area...
  42. Method for Detection of Secreted Proteins in Single Cell Assays
    Henryk Szmacinski; Fiscal Year: 2012
    ..The optical amplification will be achieved using metallic nanostructures deposited on the surface of a solid support. The method is termed MEFspot (Metal-Enhanced Fluorescence spot)...
  43. Amelogenin degradation by MMP20 and KLK4 in enamel biomineralization
    Wu Li; Fiscal Year: 2013
    ..from a layer of enamel protein matrix that is predominated by amelogenins (>90%), which forms special nanostructures to modulate crystal formation...
  44. Biodegradable hollow CuS nanoparticles for photothermal cancer therapy
    Wei Lu; Fiscal Year: 2013
    ..Nanoparticles such as gold nanostructures, along with strong photothermal coupling effect, have been shown to greatly enhance the efficacy of PTA...
  45. Bar Domains and Neuronal Membrane Structure
    Tobias Meyer; Fiscal Year: 2013
    ..We developed a novel assay to investigate curvature dependent processes that is based on fabricated nanostructures that trigger plasma membrane curvature in living cells...
  46. Small Molecule Self-Assembly in Aqueos Media
    Jose M Rivera; Fiscal Year: 2013
    ..Supramolecular chemistry offers an attractive strategy for constructing self-made nanostructures by programming the appropriate information in their molecular building blocks...
  47. Preclinical platform for theranostic nanoparticles in pancreatic cancer
    NANCY J HALAS; Fiscal Year: 2013
    ..Specifically this proposal will address the pre-clinical deployment aspects of gold nanostructures with NIR tunable Plasmon resonance...
  48. Thio-Ether Nucleic Acids: Clicking Together Synthetic Poly(Nucleic Acids)
    CHRISTOPHER JAMES KLOXIN; Fiscal Year: 2013
    ..and translation as well as being capable of inducing organization and enabling the formation of designed nanostructures. DNA performs numerous natural biological functions as well as being used in drug development, biodetection, ..
  49. Rational design and targeted selection of DNA-scaffolded nicotine vaccines
    Yung Chang; Fiscal Year: 2013
    ..Specifically, we will explore programmable DNA-nanostructures to assemble nicotine and other immunogenic components to enhance the immunogenicity and efficacy of the ..
  50. The Johns Hopkins Cancer Nanotechnology Training Center
    Denis Wirtz; Fiscal Year: 2013
    ..CNTC fellows will view interactions between nanostructures and biological systems in physical, biological, and biomedical terms and will become adept at emerging ..
  51. Non-viral gene delivery with DNA nanostructures
    Harry Bermudez; Fiscal Year: 2012
    ..Based on our knowledge of self-assembly, and the ability to "program" DNA into nanostructures, it is natural to ask if these nanostructures can be alternatives to carrier-based non-viral gene delivery...
  52. Metallic Surfaces and Particles in DNA Analysis
    Joseph R Lakowicz; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): We propose to continue our development of metallic nanostructures (MNS) for DNA analysis...
  53. RNA Nanomotor Based Active Devices for Biology and Medicine
    Rashid Bashir; Fiscal Year: 2009
    ..In this project, we propose to develop active nanostructures and systems based on biological nanomotors...
  54. Ribosome-based Single Molecule Method to Acquire Sequence Data from Genomes
    Wlodek Mandecki; Fiscal Year: 2010
    ..construct a synthetic template and demonstrate the performance of the system on this template;(iv) investigate nanostructures capable of enhancing fluorescence, (v) study the behavior of single molecules in the system;and (vi) ..
  55. Therapeutic Angiogenesis in Vascular Medicine IV
    Raj Kishore; Fiscal Year: 2013
    ..RGDS) we will extend preliminary data generated in our labs indicating that RGDS-presenting PA nanostructures enhance EPC function and investigate certain mechanisms responsible for these effects in models of critical ..
  56. Detection of Category A Pathogens by Gold Nanoparticles
    Steven Wolinsky; Fiscal Year: 2007
    ..Preliminary data show that detection assays based on these novel nanostructures are substantially more sensitive and selective than conventional assays based on fluorophore-labeled DNA ..
  57. BIOTECHNOLOGY RESOURCE DIGITAL ELECTRO-OPTICAL IMAGING
    Warren R Zipfel; Fiscal Year: 2010
    ..3) Venturesome biotechnology developments based on new technologies, including optical nanostructures, nonlinear photochemistry and correlation spectroscopy to address several crucial but refractory challenges of ..
  58. Nanostructures For Engineering Immune Responses of Dendritic Cells
    Gang yu Liu; Fiscal Year: 2013
    ..provided by applicant): The objective of this R21 proposal is to demonstrate the concept that engineered nanostructures of ligands provide a highly effective platform for the investigation and programming of the immune response of ..
  59. Reconstructing Sub-cellular Structure using Plasmonic Metamaterials
    Teri Wang Odom; Fiscal Year: 2011
    ..These new types of metal nanostructures can be integrated with standard optical microscopes...
  60. Enzyme-instructed self-assembly for anticancer nanomedicine
    Bing Xu; Fiscal Year: 2013
    ..This research will potentially provide a new platform for creating synthetic nanostructures as nanomedicine to target cancer cells...
  61. Reconstructing Sub-cellular Structure using Plasmonic Metamaterials
    Teri Wang Odom; Fiscal Year: 2012
    ..These new types of metal nanostructures can be integrated with standard optical microscopes...
  62. Graphene Nanostructures as a New Platform for Ultrasensitive Multiplexed Biologic
    Yu Huang; Fiscal Year: 2010
    DESCRIPTION (Provided by the applicant) Abstract: Graphene Nanostructures as a New Platform for Ultrasensitive Multiplexed Biological Sensors Abstract The detection and quantification of chemical and biological species are central to ..
  63. Hybrid Nanostructures for Wireless In Vivo Action Potential Sensing
    Joshua Goldberger; Fiscal Year: 2009
    ..Then, we will investigate the FRET dye (ii) optical characteristics on in vitro neural networks via simultaneous optical and electrical voltage sensing, and (iii) adhesion kinetics and cytotoxicities. ..
  64. Ultrasensitive, Label-free Silicon Nanowire Biosensing Arrays
    SEASON WONG; Fiscal Year: 2009
    ..processes and have difficulties with integration, requiring delicate transfer and positioning of individual nanostructures. Other difficulties include controlling NW doping and contact resistance...
  65. Novel Nano-Constructs to Target and Destroy Tumor Neovasculature
    Michael McDevitt; Fiscal Year: 2009
    ..These novel synthetic nanostructures will be designed as hybrid molecules consisting of biologics, radionuclides and carbon nanotubes and should ..
  66. NANOCRYSTALLINE COATING FOR UHMWPE PROSTHESES
    FEREYDOON NAMAVAR; Fiscal Year: 1999
    ..The proposed coatings would combine hardness, toughness, and low internal stress provided by multiphase nanostructures and superior adhesion provided by a gradual transition of chemical and mechanical properties through the film ..
  67. DNA Nanoarrays Printed via Dip Pen Nanolithography
    NABIL AMRO; Fiscal Year: 2003
    The goal of this research is to develop novel, biologically functional DNA nanostructures that dramatically enhance the reproducibility, sensitivity, and spatial density of chip-based DNA assays...
  68. Dendritic Diblock Copolymer Micelles as New Targeted Drug Delivery Systems
    Paula Hammond; Fiscal Year: 2006
    ..that by creating linear-dendritic block copolymers which can act as amphiphiles in solution, much larger nanostructures than traditional dendrimers can be constructed through the formation of micelles containing N chain aggregates ..
  69. ALLOSTERIC REGULATION OF SUBSTRATE CHANNELING
    Michael Dunn; Fiscal Year: 2006
    ..and Disease derives from the new knowledge about structure-function relationships for the class of protein nanostructures consisting of enzyme-enzyme complexes that are organized into metabolic pathways...
  70. 2006 Tetrapyrroles Chemistry and Biology of Gordon Research Conference
    Ann Smith; Fiscal Year: 2006
    ..g. circadian rhythms; global iron homeostasis); nanostructures and artificial heme-proteins; and, a workshop on the porphyrias with a focus on metabolomics...
  71. Nanostructured Block-copolymer Reinforced Calcium Phosphate Composites
    LARA ESTROFF; Fiscal Year: 2009
    ..diblock copolymers to direct the assembly of ACP particles into materials with defined 1-D, 2-D, and 3-D nanostructures. 3) Controlled crystallization of the amorphous, inorganic phase of the nanostructured composites...
  72. Biomolecule Nanoarray Fabrication Methods and Apparatus
    NABIL AMRO; Fiscal Year: 2007
    ..DESCRIPTION (provided by applicant): The goal of this research is to develop novel, biologically functional nanostructures that dramatically enhance the reproducibility, sensitivity, and spatial density of chip based assays...
  73. Integrated Nanosystems for Diagnosis and Therapy
    KAREN WOOLEY; Fiscal Year: 2009
    ..aims for this PEN: (1) Preparation and assembly of programmed, integrated nanosystems;(2) Application of nanostructures for imaging at increased levels of sensitivity;(3) Imaging of gene expression by recognition of mRNA ..
  74. Engineered Proteins for Nanotechnology Applications
    Patricia Weber; Fiscal Year: 2007
    ..Our objective is to develop a set of molecular components allowing the systematic assembly of functional nanostructures constructed of molecular "struts" and "nodes"...
  75. Use of Silver Nanostructures on Microtransponders in Ultra-sensitive Assay
    Wlodek Mandecki; Fiscal Year: 2009
    ..sensitivity of the microtransponder-based multiplexed bioassays by (1) introducing a coating with silver nanostructures onto the microtransponders (MTPs) to enhance fluorescence, and (2) improving the fluorescence detection limit ..
  76. Self-Assembling Nanostructures of Defined Size
    David Hansen; Fiscal Year: 2009
    ..These molecular assemblies may serve as delivery vehicles for drugs that otherwise exhibit poor pharmacokinetics. Ultimately, they may also serve as scaffolds for the creation of artificial enzymes. ..
  77. Metal Enhancement for Near-IR Fluorescence Based Membrane Assays
    Jon Anderson; Fiscal Year: 2007
    ..Little information exists, however, on the ability of silver nanostructures to enhance fluorophores deposited onto porous membrane surfaces...
  78. Multifunctional low-density lipoprotein nanoplatforms
    Gang Zheng; Fiscal Year: 2005
    Lipoproteins are naturally-existing nanostructures (8 - 1000 nm) responsible for the transport of cholesterol and other lipids in the blood circulation...
  79. Advanced Multi-channel Recording Electrodes
    NADER KALKHORAN; Fiscal Year: 2002
    ..We propose to use the porous silicon nanostructures as a scaffold system, attached to the CBMSE array...