social isolation

Summary

Summary: The separation of individuals or groups resulting in the lack of or minimizing of social contact and/or communication. This separation may be accomplished by physical separation, by social barriers and by psychological mechanisms. In the latter, there may be interaction but no real communication.

Top Publications

  1. ncbi Does rejection hurt? An FMRI study of social exclusion
    Naomi I Eisenberger
    Department of Psychology, Franz Hall, University of California, Los Angeles, Los Angeles, CA 90095 1563, USA
    Science 302:290-2. 2003
  2. ncbi Social isolation-induced decreases in both the abundance of neuroactive steroids and GABA(A) receptor function in rat brain
    M Serra
    Department of Experimental Biology, University of Cagliari, Cagliari, Italy
    J Neurochem 75:732-40. 2000
  3. ncbi Cyberostracism: effects of being ignored over the Internet
    K D Williams
    School of Psychology, University of New South Wales, Sydney, Australia
    J Pers Soc Psychol 79:748-62. 2000
  4. pmc Social disconnectedness, perceived isolation, and health among older adults
    Erin York Cornwell
    Department of Sociology, Cornell University, Ithaca, NY 14853, USA
    J Health Soc Behav 50:31-48. 2009
  5. pmc Social isolation, loneliness, and all-cause mortality in older men and women
    Andrew Steptoe
    Department of Epidemiology and Public Health, University College London, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 110:5797-801. 2013
  6. pmc Brain 5alpha-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation
    E Dong
    The Psychiatric Institute, Department of Psychiatry, University of Illinois, College of Medicine, 1601 West Taylor Street, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 98:2849-54. 2001
  7. ncbi Behavioural and neurochemical effects of post-weaning social isolation in rodents-relevance to developmental neuropsychiatric disorders
    Kevin C F Fone
    Institute of Neuroscience, School of Biomedical Sciences, Medical School, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Neurosci Biobehav Rev 32:1087-102. 2008
  8. ncbi Abnormalities of presynaptic protein CDCrel-1 in striatum of rats reared in social isolation: relevance to neural connectivity in schizophrenia
    Alasdair M Barr
    Centre for Complex Disorders, University of British Columbia, 828 West 10th Avenue, Vancouver, BC, Canada V5Z 1L8
    Eur J Neurosci 20:303-7. 2004
  9. pmc Social isolation in adolescence alters behaviors in the forced swim and sucrose preference tests in female but not in male rats
    Suzie Hong
    Department of Anesthesiology, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, United States
    Physiol Behav 105:269-75. 2012
  10. ncbi Loneliness, lack of emotional support, lack of companionship, and the likelihood of having a heart condition in an elderly sample
    Dara Sorkin
    Department of Psychology and Social Behavior, University of California, Irvine 92697 7085, USA
    Ann Behav Med 24:290-8. 2002

Detail Information

Publications331 found, 100 shown here

  1. ncbi Does rejection hurt? An FMRI study of social exclusion
    Naomi I Eisenberger
    Department of Psychology, Franz Hall, University of California, Los Angeles, Los Angeles, CA 90095 1563, USA
    Science 302:290-2. 2003
    ..ACC changes mediated the RVPFC-distress correlation, suggesting that RVPFC regulates the distress of social exclusion by disrupting ACC activity...
  2. ncbi Social isolation-induced decreases in both the abundance of neuroactive steroids and GABA(A) receptor function in rat brain
    M Serra
    Department of Experimental Biology, University of Cagliari, Cagliari, Italy
    J Neurochem 75:732-40. 2000
    The effects of social isolation on behavior, neuroactive steroid concentrations, and GABA(A) receptor function were investigated in rats...
  3. ncbi Cyberostracism: effects of being ignored over the Internet
    K D Williams
    School of Psychology, University of New South Wales, Sydney, Australia
    J Pers Soc Psychol 79:748-62. 2000
    ..In Study 2, ostracized participants were more likely to conform on a subsequent task. The results are discussed in terms of supporting K. D. Williams's (1997) need threat theory of ostracism...
  4. pmc Social disconnectedness, perceived isolation, and health among older adults
    Erin York Cornwell
    Department of Sociology, Cornell University, Ithaca, NY 14853, USA
    J Health Soc Behav 50:31-48. 2009
    Previous research has identified a wide range of indicators of social isolation that pose health risks, including living alone, having a small social network, infrequent participation in social activities, and feelings of loneliness...
  5. pmc Social isolation, loneliness, and all-cause mortality in older men and women
    Andrew Steptoe
    Department of Epidemiology and Public Health, University College London, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 110:5797-801. 2013
    Both social isolation and loneliness are associated with increased mortality, but it is uncertain whether their effects are independent or whether loneliness represents the emotional pathway through which social isolation impairs health...
  6. pmc Brain 5alpha-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation
    E Dong
    The Psychiatric Institute, Department of Psychiatry, University of Illinois, College of Medicine, 1601 West Taylor Street, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 98:2849-54. 2001
    ..roles of ALLO and 5alpha-DHP synthesized in brain, we have adopted a mouse model involving protracted social isolation. In the frontal cortex of mice, socially isolated for 6 weeks, both neurosteroids were decreased by ..
  7. ncbi Behavioural and neurochemical effects of post-weaning social isolation in rodents-relevance to developmental neuropsychiatric disorders
    Kevin C F Fone
    Institute of Neuroscience, School of Biomedical Sciences, Medical School, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Neurosci Biobehav Rev 32:1087-102. 2008
    Exposing mammals to early-life adverse events, including maternal separation or social isolation, profoundly affects brain development and adult behaviour and may contribute to the occurrence of psychiatric disorders, such as depression ..
  8. ncbi Abnormalities of presynaptic protein CDCrel-1 in striatum of rats reared in social isolation: relevance to neural connectivity in schizophrenia
    Alasdair M Barr
    Centre for Complex Disorders, University of British Columbia, 828 West 10th Avenue, Vancouver, BC, Canada V5Z 1L8
    Eur J Neurosci 20:303-7. 2004
    Post-weaning social isolation-rearing of rats leads to behavioural and neurochemical sequelae that model aspects of schizophrenia, and it may be useful to test hypotheses related to putative molecular mechanisms of the illness...
  9. pmc Social isolation in adolescence alters behaviors in the forced swim and sucrose preference tests in female but not in male rats
    Suzie Hong
    Department of Anesthesiology, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, United States
    Physiol Behav 105:269-75. 2012
    Social interactions in rodents are rewarding and motivating and social isolation is aversive...
  10. ncbi Loneliness, lack of emotional support, lack of companionship, and the likelihood of having a heart condition in an elderly sample
    Dara Sorkin
    Department of Psychology and Social Behavior, University of California, Irvine 92697 7085, USA
    Ann Behav Med 24:290-8. 2002
    b>Social isolation has been linked to a variety of adverse health outcomes, including cardiovascular disease...
  11. ncbi Social isolation-induced increase in alpha and delta subunit gene expression is associated with a greater efficacy of ethanol on steroidogenesis and GABA receptor function
    Mariangela Serra
    Department of Experimental Biology, University of Cagliari, Cagliari, Italy
    J Neurochem 98:122-33. 2006
    Previously we have demonstrated that social isolation of rats reduces both the cerebrocortical and plasma concentrations of 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha,5alpha-TH PROG), and potentiates the positive effects of acute ..
  12. ncbi When inclusion costs and ostracism pays, ostracism still hurts
    Ilja van Beest
    Department of Social and Organizational Psychology, Leiden University, Leiden, Netherlands
    J Pers Soc Psychol 91:918-28. 2006
    ..In these conditions, participants were sensitive to financial incentives. However, even then participants felt worse when given no positive attention than when given punitive attention...
  13. pmc "It is me who endures but my family that suffers": social isolation as a consequence of the household cost burden of Buruli ulcer free of charge hospital treatment
    Koen Peeters Grietens
    Partners for Applied Social Sciences PASS International, Leuven, Belgium
    PLoS Negl Trop Dis 2:e321. 2008
    ..b>Social isolation itself was cited by in-patients as the principal cause for abandonment of biomedical treatment...
  14. ncbi The dynamics of stigma in leprosy
    M L Heijnders
    Research Fellow, Trimbos Institute
    Int J Lepr Other Mycobact Dis 72:437-47. 2004
    ..Stigma enforces already existing inequalities in social class, gender, and age...
  15. ncbi Loneliness and risk of Alzheimer disease
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL 60612, USA
    Arch Gen Psychiatry 64:234-40. 2007
    b>Social isolation in old age has been associated with risk of developing dementia, but the risk associated with perceived isolation, or loneliness, is not well understood.
  16. pmc Social isolation
    John T Cacioppo
    Center for Cognitive and Social Neuroscience, University of Chicago, Illinois, USA
    Ann N Y Acad Sci 1231:17-22. 2011
    ..b>Social isolation represents a lens through which to investigate these behavioral, neural, hormonal, cellular, and genetic ..
  17. pmc Measuring social isolation among older adults using multiple indicators from the NSHAP study
    Erin York Cornwell
    Department of Sociology, Cornell University, 336 Uris Hall, Ithaca, NY 14853, USA
    J Gerontol B Psychol Sci Soc Sci 64:i38-46. 2009
    ..We suggest that these indicators can be combined to measure two aspects of social isolation: social disconnectedness (i.e., physical separation from others) and perceived isolation (i.e...
  18. pmc Oxytocin protects against negative behavioral and autonomic consequences of long-term social isolation
    Angela J Grippo
    Dept Psychology, Northern Illinois University, PM 357, DeKalb, IL 60115, United States
    Psychoneuroendocrinology 34:1542-53. 2009
    ..In the present study, adult female prairie voles were exposed to social isolation or continued pairing with a female sibling (control conditions) for 4 weeks...
  19. pmc Social isolation dysregulates endocrine and behavioral stress while increasing malignant burden of spontaneous mammary tumors
    Gretchen L Hermes
    Departments of Comparative Human Development, Institute for Mind and Biology, The University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 106:22393-8. 2009
    ..Our model provides a framework for studying the interaction of social neglect with genetic risk to identify mechanisms whereby psychosocial stressors increase growth and malignancy of breast cancer...
  20. ncbi Social relationships, stigma and adherence to antiretroviral therapy for HIV/AIDS
    N C Ware
    Harvard Medical School, Department of Social Medicine, Boston, MA 02115, USA
    AIDS Care 18:904-10. 2006
    ..Results suggest that persons with HIV/AIDS will not consistently subordinate other interests to prioritize adherence. Interventions aimed at supporting long-term adherence must address experienced conflicts between 'health' and 'life'...
  21. pmc Interventions targeting social isolation in older people: a systematic review
    Andy P Dickens
    Primary Care Research Group, Peninsula College of Medicine and Dentistry, University of Exeter, Smeall Building, St Luke s Campus, Magdalen Road, Exeter, EX1 2LU, UK
    BMC Public Health 11:647. 2011
    Targeting social isolation in older people is a growing public health concern...
  22. ncbi Behavioral thermoregulatory responses of single- and group-housed mice
    C J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Physiol Behav 65:255-62. 1998
    ..The results show that the typical housing conditions for single- and group-housed mice are cooler than their Ta for ideal thermal comfort...
  23. pmc The neural bases of social pain: evidence for shared representations with physical pain
    Naomi I Eisenberger
    Department of Psychology, 1285 Franz Hall, University of California, Los Angeles, CA 90095 1563, USA
    Psychosom Med 74:126-35. 2012
    ..Finally, what these shared neural substrates mean for our understanding of socially painful experience is discussed...
  24. pmc Perceived social isolation makes me sad: 5-year cross-lagged analyses of loneliness and depressive symptomatology in the Chicago Health, Aging, and Social Relations Study
    John T Cacioppo
    Center for Cognitive and Social Neuroscience, University of Chicago, IL 60637, USA
    Psychol Aging 25:453-63. 2010
    ..not vice versa, and that this temporal association was not attributable to demographic variables, objective social isolation, dispositional negativity, stress, or social support...
  25. ncbi The impact of social isolation on the health status and health-related quality of life of older people
    Annie Hawton
    Institute of Health Service Research, Peninsula College of Medicine and Dentistry, University of Exeter, Veysey Building, Salmon Pool Lane, Exeter, Devon EX2 4SG, UK
    Qual Life Res 20:57-67. 2011
    To investigate for socially isolated older people, and older people at risk of social isolation: (1) health status and health-related quality of life (HRQL); (2) the relationship between social isolation and health status/HRQL; (3) the ..
  26. pmc Anxiety states induced by post-weaning social isolation are mediated by CRF receptors in the dorsal raphe nucleus
    Adam C Bledsoe
    Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, The University of South Dakota, 414 E Clark St, Vermillion, SD 57069, USA
    Brain Res Bull 85:117-22. 2011
    Post-weaning social isolation of rats is utilized as a model of early life stress. We have previously demonstrated that rats exposed to post-weaning social isolation exhibit greater anxiety-like behaviors as adults...
  27. ncbi A single exposure to social isolation in domestic piglets activates behavioural arousal, neuroendocrine stress hormones, and stress-related gene expression in the brain
    E Kanitz
    Research Unit Behavioural Physiology, Research Institute for the Biology of Farm Animals, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    Physiol Behav 98:176-85. 2009
    ..Here, we investigated the effects of a single social isolation (4 h) of domestic piglets on both behavioural alterations in open-field tests and modifications in the ..
  28. ncbi Influence of social isolation in the rat on serotonergic function and memory--relevance to models of schizophrenia and the role of 5-HT₆ receptors
    Charles A Marsden
    School of Biomedical Sciences, Medical School, Queen s Medical Centre, The University of Nottingham, Nottingham NG7 2UH, UK
    Neuropharmacology 61:400-7. 2011
    ..The isolation reared rat attempts to model adverse effects that human social isolation (absence of social contact) can have on normal brain development...
  29. ncbi Post weaning social isolation influences spatial cognition, prefrontal cortical synaptic plasticity and hippocampal potassium ion channels in Wistar rats
    M N Quan
    Laboratory of Neurophysiology, School of Medicine, Nankai University, Tianjin, 300071, PR China
    Neuroscience 169:214-22. 2010
    ..These data suggested that isolation rearing can impair the spatial cognition of rats, with the possible mechanisms of affecting prefrontal cortical synaptic plasticity and hippocampal potassium ion channel currents...
  30. ncbi The postweaning social isolation in C57BL/6 mice: preferential vulnerability in the male sex
    Susanna Pietropaolo
    Laboratory of Behavioural Neurobiology, Swiss Federal Institute of Technology Zurich, Schorenstrasse 16, CH 8603 Schwerzenbach, Switzerland
    Psychopharmacology (Berl) 197:613-28. 2008
    ..This has led to the application of social isolation in laboratory animals to model the impact of environmental factors on the aetiopathology of schizophrenia...
  31. pmc Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene
    Toshio Maekawa
    Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, Tsukuba, Ibaraki, Japan
    EMBO J 29:196-208. 2010
    ..However, identities of transcription factors that regulate gene expression in response to chronic social isolation stress remain elusive...
  32. pmc Social isolation induces behavioral and neuroendocrine disturbances relevant to depression in female and male prairie voles
    Angela J Grippo
    Department of Psychiatry, Brain Body Center, University of Illinois at Chicago, Chicago, IL 60612, USA
    Psychoneuroendocrinology 32:966-80. 2007
    ..social interactions may be protective against stressors and certain mental and physical illness, while social isolation may be a powerful stressor...
  33. pmc Measuring HIV stigma for PLHAs and nurses over time in five African countries
    William L Holzemer
    International Programs at the University of California, San Francisco, School of Nursing, USA
    SAHARA J 6:76-82. 2009
    ..These results have implications for stigma reduction interventions, particularly focused at health care providers who experience HIV stigma by association...
  34. pmc Social isolation, support, and capital and nutritional risk in an older sample: ethnic and gender differences
    Julie L Locher
    Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Alabama at Birmingham, 219 Community Health Services Building, 933 19th Street South, Birmingham, AL 35294 2041, USA
    Soc Sci Med 60:747-61. 2005
    This study examines the relationships that exist between social isolation, support, and capital and nutritional risk in older black and white women and men...
  35. ncbi Predictors and subjective causes of loneliness in an aged population
    N Savikko
    The Central Union for the Welfare of the Aged, Malmin Kauppatie 26, 00700 Helsinki, Finland
    Arch Gerontol Geriatr 41:223-33. 2005
    ..The most common subjective causes for loneliness were illnesses, death of a spouse and lack of friends. Loneliness seems to derive from societal life changes as well as from natural life events and hardships originating from aging...
  36. ncbi Social isolation-induced increase in the sensitivity of rats to the steroidogenic effect of ethanol
    Mariangela Serra
    Department of Experimental Biology, Center of Excellence for Neurobiology of Drug Dependence, University of Cagliari, Cagliari, Italy
    J Neurochem 85:257-63. 2003
    b>Social isolation of rats for 30 days immediately after weaning results in marked decreases in the cerebrocortical and plasma concentrations of pregnenolone, progesterone, 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha,5alpha-TH PROG), and ..
  37. pmc Perceived social isolation and cognition
    John T Cacioppo
    Center for Cognitive and Social Neuroscience, University of Chicago, 5848 S University Avenue, Chicago, IL 60637, USA
    Trends Cogn Sci 13:447-54. 2009
    ..an irrepressibly meaning-making species, are, in normal circumstances, dramatically affected by perceived social isolation. Research indicates that perceived social isolation (i.e...
  38. pmc Social isolation-induced aggression potentiates anxiety and depressive-like behavior in male mice subjected to unpredictable chronic mild stress
    Xian Cang Ma
    Department of Psychiatry, First Affiliated Hospital of Medical College of Xi an Jiaotong University, Xian, China
    PLoS ONE 6:e20955. 2011
    ..It is also well known that social isolation in male mice results in aggressive behavior...
  39. ncbi Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist
    R M Barrientos
    Department of Psychology and Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309, USA
    Neuroscience 121:847-53. 2003
    ..g. peripheral administration of lipopolysaccharide, i.c.v. glycoprotein 120, social isolation) as well as the intrahippocampal injection of IL-1beta following a learning experience, dramatically impair ..
  40. pmc In the eye of the beholder: individual differences in perceived social isolation predict regional brain activation to social stimuli
    John T Cacioppo
    University of Chicago, Chicago, IL 60637, USA
    J Cogn Neurosci 21:83-92. 2009
    Prior research has shown that perceived social isolation (loneliness) motivates people to attend to and connect with others but to do so in a self-protective and paradoxically self-defeating fashion...
  41. ncbi The ecological relationship between deprivation, social isolation and rates of hospital admission for acute psychiatric care: a comparison of London and New York City
    Sarah Curtis
    Department of Geography, Health Research Group, Queen Mary College, University of London, London, UK
    Health Place 12:19-37. 2006
    ..We discuss the interpretation of these results and the issues they raise in terms of the potential and limitations of international comparison...
  42. pmc Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice
    Roberto C Agis-Balboa
    Psychiatric Institute, Department of Psychiatry, School of Medicine, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 104:18736-41. 2007
    ..Importantly, 3alpha-HSD mRNA expression was unchanged by protracted social isolation (Si)...
  43. ncbi Effects of a program to prevent social isolation on loneliness, depression, and subjective well-being of older adults: a randomized trial among older migrants in Japan
    Tami Saito
    School of Public Health, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Arch Gerontol Geriatr 55:539-47. 2012
    b>Social isolation among the elderly is a concern in developed countries...
  44. pmc Effects of social isolation on glucocorticoid regulation in social mammals
    Louise C Hawkley
    Department of Psychology and Center for Cognitive and Social Neuroscience, University of Chicago, Chicago, IL, USA
    Horm Behav 62:314-23. 2012
    ..Here, we review the effects of social isolation on the functioning of the HPA axis in social species, and on glucocorticoid physiology in social mammals in ..
  45. ncbi Social brain development and the affective consequences of ostracism in adolescence
    Catherine Sebastian
    Institute of Cognitive Neuroscience, UCL, UK
    Brain Cogn 72:134-45. 2010
    ..This suggests that the ability to regulate distress resulting from ostracism continues to develop between adolescence and adulthood. The results are discussed in the context of models of neurocognitive development...
  46. ncbi Social isolation induces deficit of latent learning performance in mice: a putative animal model of attention deficit/hyperactivity disorder
    Hirofumi Ouchi
    Division of Medicinal Pharmacology, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Behav Brain Res 238:146-53. 2013
    b>Social isolation of rodents (SI) elicits a variety of stress responses such as increased aggressiveness, hyper-locomotion, and reduced susceptibility to pentobarbital...
  47. ncbi Under threat of social exclusion, females exclude more than males
    Joyce F Benenson
    Department of Psychology, Emmanuel College, 400 The Fenway, Boston, MA 02115, USA
    Psychol Sci 22:538-44. 2011
    ..These results support the idea that adult females are more likely than males to form preventive exclusionary alliances when faced with a social threat. The results further suggest that females and males compete in different ways...
  48. pmc Social isolation and adult mortality: the role of chronic inflammation and sex differences
    Yang Claire Yang
    Department of Sociology, Lineberger Comprehensive Cancer Center, and Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA
    J Health Soc Behav 54:183-203. 2013
    ..We assessed the process by which social isolation increases the risk for all-cause and chronic disease mortality through proinflammatory mechanisms...
  49. pmc Does low self-esteem enhance social pain? The relationship between trait self-esteem and anterior cingulate cortex activation induced by ostracism
    Keiichi Onoda
    Department of Neurology, Faculty of Medicine, Shimane University, 89 1, Enyacho, Izumo, 693 8501, Japan
    Soc Cogn Affect Neurosci 5:385-91. 2010
    ..Heightened dorsal anterior cortex activity and a corresponding connection with the prefrontal cortex might be one possible explanation for the greater levels of social pain observed experienced by individuals with low trait self-esteem...
  50. ncbi Exclusion and micro-rejection: event-related potential response predicts mitigated distress
    MICHAEL J CROWLEY
    Yale Child Study Center, Yale School of Medicine, New Haven, Connecticut 06473, USA
    Neuroreport 20:1518-22. 2009
    ..Relations emerged even during fair play, providing a window into the neural basis of more subtle social-cognitive perceptual processes...
  51. ncbi No effect of social exclusion on salivary cortisol secretion in women in a randomized controlled study
    Cäcilia Zöller
    Institute of Medical Psychology, University of Giessen, Giessen, Germany
    Psychoneuroendocrinology 35:1294-8. 2010
    ..To experimentally vary social exclusion we employed a highly standardized paradigm (Cyberball) which already has been shown to affect subjective well-being and some physiological parameters...
  52. ncbi Living alone and deliberate self-harm: a case-control study of characteristics and risk factors
    Camilla Haw
    Centre for Suicide Research, Oxford, UK
    Soc Psychiatry Psychiatr Epidemiol 46:1115-25. 2011
    ..Little is known about deliberate self-harm (DSH) patients who live alone. We conducted a study of the characteristics of DSH patients who live alone using data from the Oxford Monitoring System for Attempted Suicide...
  53. ncbi Social isolation stress-induced aggression in mice: a model to study the pharmacology of neurosteroidogenesis
    Kinzo Matsumoto
    Division of Medicinal Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630, Sugitani, Toyama, 930 0194, Japan
    Stress 8:85-93. 2005
    Long-term social isolation of laboratory animals is a model to study the behavioral and neurochemical consequences of the absence of social interaction in rodents...
  54. ncbi Facial emotional expression in reaction to social exclusion in borderline personality disorder
    K Staebler
    Department of Psychology, Freie Universitat Berlin, Germany
    Psychol Med 41:1929-38. 2011
    ..In this study, facial emotional expressions, which are crucial for adaptive interactions in social contexts, were assessed in patients with BPD in response to social exclusion...
  55. pmc Gender-dependent effects of enriched environment and social isolation in ischemic retinal lesion in adult rats
    Peter Kiss
    PTE MTA Lendület PACAP Research Team, Department of Anatomy, University of Pecs, Pecs 7624, Hungary
    Int J Mol Sci 14:16111-23. 2013
    ..The aim of the present study, therefore, was to examine the effects of environmental enrichment and social isolation in retinal ischemia...
  56. ncbi Loneliness, social isolation, and behavioral and biological health indicators in older adults
    Aparna Shankar
    Department of Epidemiology and Public Health, University College London, London, UK
    Health Psychol 30:377-85. 2011
    A number of mechanisms have been proposed through which social isolation and loneliness may affect health, including health-related behavioral and biological factors...
  57. ncbi Early-life maternal separation and social isolation produce an increase in impulsive action but not impulsive choice
    Vedran Lovic
    Department of Psychology, University of Toronto Mississauga
    Behav Neurosci 125:481-91. 2011
    ..In contrast, AR rats did not display an increase in impulsive choice. Overall, these experiments show that early life maternal and social separation have different effects on the 2 forms of impulsivity...
  58. ncbi Control, uncertainty, and expectations for the future: a qualitative study of the impact of drought on a rural Australian community
    G M Sartore
    Centre for Rural and Remote Mental Health, University of Newcastle, New South Wales, Australia
    Rural Remote Health 8:950. 2008
    ..The stressors affecting farming communities during times of drought are likely to be associated with increased risk of mental health problems...
  59. ncbi Association between social isolation and inflammatory markers in depressed and non-depressed individuals: results from the MONICA/KORA study
    S Hafner
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology II, 85764 Neuherberg, Germany
    Brain Behav Immun 25:1701-7. 2011
    ..We investigate whether chronic stress also induces an exaggerated inflammatory response in individuals with increased depression features. As model for chronic stress, social isolation was chosen.
  60. ncbi HIV-related stigma, isolation, discrimination, and serostatus disclosure: a global survey of 2035 HIV-infected adults
    Jean B Nachega
    1Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Int Assoc Physicians AIDS Care (Chic) 11:172-8. 2012
    ..Little is known globally about the perspectives of people living with HIV/AIDS (PLWHA) on perceived HIV-related stigma and its consequences...
  61. ncbi Childhood peer status and adult susceptibility to anxiety and depression. A 30-year hospital follow-up
    Bitte Modin
    Centre for Health Equity Studies CHESS, Stockholm University Karolinska Institutet, Stockholm, Sweden
    J Abnorm Child Psychol 39:187-99. 2011
    ....
  62. ncbi The mGluR2/3 agonist LY379268 reverses post-weaning social isolation-induced recognition memory deficits in the rat
    Caitlin A Jones
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
    Psychopharmacology (Berl) 214:269-83. 2011
    ..The type II metabotropic glutamate receptor (mGluR2/3) is a novel, potential therapeutic target requiring evaluation in appropriate preclinical models of schizophrenia...
  63. ncbi Loneliness, health and depression in older males
    F M Alpass
    School of Psychology, Massey University, New Zealand
    Aging Ment Health 7:212-6. 2003
    Loneliness and social isolation, particularly in the older adult, have been shown to influence psychosocial well-being...
  64. pmc CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits
    Deanna L Wallace
    Department of Psychiatry and Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
    Nat Neurosci 12:200-9. 2009
    Here, we characterized behavioral abnormalities induced by prolonged social isolation in adult rodents...
  65. ncbi Blockade of dopamine D₃ but not D₂ receptors reverses the novel object discrimination impairment produced by post-weaning social isolation: implications for schizophrenia and its treatment
    David J G Watson
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    Int J Neuropsychopharmacol 15:471-84. 2012
    ..D₂ receptor antagonists on the cognitive impairment and hyperactivity produced by social isolation of rat pups, in a neurodevelopmental model of certain deficits of schizophrenia...
  66. ncbi Blockade of dorsal hippocampal kappa-opioid receptors increases blood pressure in normotensive and isolation-induced hypertensive rats
    Rebecca C Wright
    Department of Pharmacology, School of Medicine, East Carolina University, Greenville, NC 27858, USA
    Neuropeptides 37:127-32. 2003
    ..These data suggest that the rat hippocampal kappa-opioid receptor system and the endogenous neuropeptide dynorphin may be involved in the central neural regulation of blood pressure...
  67. ncbi [Diogenes syndrome: a transnosographic approach]
    C Hanon
    EPS Erasme, 143, avenue Armand Guillebaud, 92160 Antony
    Encephale 30:315-22. 2004
    ..This behaviour therefore plays a repairing role for psychic functioning, allowing psychic survival...
  68. ncbi Diogenes syndrome: the self-neglect elderly
    C A Reyes-Ortiz
    Department of Family Medicine, Valle University School of Medicine, Cali, Columbia
    Compr Ther 27:117-21. 2001
    ..Secondary DS is related to mental disorders. Its management includes day care center and community care...
  69. ncbi Protective effect of Withania somnifera dunal root extract against protracted social isolation induced behavior in rats
    Girdhari Lal Gupta
    Department of Pharmacology, B N College of Pharmacy, Udaipur
    Indian J Physiol Pharmacol 51:345-53. 2007
    This study investigated the effect of Withania somnifera Dunal (WS) root extract and diazepam in social isolation induced behavior such as anxiety and depression in rats...
  70. ncbi Child physical abuse and self-perceived social isolation among adolescents
    Gregory C Elliott
    Brown University, RI, USA
    J Interpers Violence 20:1663-84. 2005
    This research examines the connection between physical abuse and social isolation. Using data from the National Youth Survey, a measure of self-perceived social isolation was constructed indicating the extent to which respondents feel ..
  71. ncbi Postweaning social isolation enhances morphological changes in the neonatal ventral hippocampal lesion rat model of psychosis
    Glenda Alquicer
    Instituto de Fisiologia, Universidad Autonoma de Puebla, 14 Sur 6301, CP 72570, Puebla, Mexico
    J Chem Neuroanat 35:179-87. 2008
    ..Moreover, postweaning social isolation induces major decreases in dendritic spiny density of PFC neurons...
  72. ncbi Effect of social isolation on stress-related behavioural and neuroendocrine state in the rat
    Isabelle C Weiss
    Behavioural Neurobiology Laboratory, Swiss Federal Institute of Technology Zurich, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland
    Behav Brain Res 152:279-95. 2004
    The present study investigated the effects of post-weaning social isolation (SI) on behavioural and neuroendocrine reactivity to stress of male and female rats...
  73. ncbi Social isolation and stress-related cardiovascular, lipid, and cortisol responses
    Nina Grant
    Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1E6BT, UK
    Ann Behav Med 37:29-37. 2009
    Social support is a strong and consistent predictor of health outcomes, and social isolation predicts increased morbidity and mortality. The mediating processes are not completely understood.
  74. ncbi Behavioral abnormality and pharmacologic response in social isolation-reared mice
    Hiroyuki Koike
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Behav Brain Res 202:114-21. 2009
    b>Social isolation (SI) rearing in rodents causes a variety of behavioral changes, including hyperlocomotion, anxiety, impulsivity, aggression, and learning and memory deficits...
  75. pmc Chronic social isolation and chronic variable stress during early development induce later elevated ethanol intake in adult C57BL/6J mice
    Marcelo F Lopez
    Medical University of South Carolina, Charleston Alcohol Research Center, Charleston, SC, USA
    Alcohol 45:355-64. 2011
    ..Importantly, this can also favor drug self-administration. These studies examined the effects of chronic social isolation and/or variable stress experiences during early development on subsequent voluntary ethanol intake in adult ..
  76. ncbi Social isolation stress during the third week of life has age-dependent effects on spatial learning in rats
    Deborah F Frisone
    Department of Psychology, Bronfman Science Center, Williams College, Williamstown, MA 01267, USA
    Behav Brain Res 128:153-60. 2002
    ..spatial learning would be altered in juvenile and adult rats previously exposed to a chronic stressor: 6 h of social isolation (SI) daily at 15-21 days of age...
  77. ncbi Cocaine- and amphetamine-regulated transcript peptide plays a role in the manifestation of depression: social isolation and olfactory bulbectomy models reveal unifying principles
    Manoj P Dandekar
    Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University Campus, Nagpur, India
    Neuropsychopharmacology 34:1288-300. 2009
    ..b>Social isolation as well as OBX models were undertaken to produce depression-like conditions...
  78. ncbi Involvement of alpha-MSH in the social isolation induced anxiety- and depression-like behaviors in rat
    Dadasaheb M Kokare
    Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University Campus, Nagpur 440 033, India
    Neuropharmacology 58:1009-18. 2010
    ..While social isolation significantly reduced alpha-MSH-immunoreactivity profile in all these components, re-socialization of the ..
  79. ncbi Can the higher risk of disability onset among older people who live alone be alleviated by strong social relations? A longitudinal study of non-disabled men and women
    Rikke Lund
    Section of Social Medicine, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
    Age Ageing 39:319-26. 2010
    ..to investigate if the increased risk of disability onset among older people who live alone could possibly be moderated by either high social participation or by being satisfied with the social relations...
  80. ncbi Nonphysical contact between cagemates alleviates the social isolation syndrome in C57BL/6 male mice
    Susanna Pietropaolo
    Laboratory of Behavioural Neurobiology, ETH Zurich, Schwerzenbach, Switzerland
    Behav Neurosci 122:505-15. 2008
    In rodents, social isolation during the early postweaning phase induces several behavioral abnormalities, commonly referred to as the isolation syndrome...
  81. pmc Decreased corticolimbic allopregnanolone expression during social isolation enhances contextual fear: A model relevant for posttraumatic stress disorder
    Fabio Pibiri
    Psychiatric Institute, Department of Psychiatry, University of Illinois, 1601 West Taylor Street, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 105:5567-72. 2008
    Mice subjected to social isolation (3-4 weeks) exhibit enhanced contextual fear responses and impaired fear extinction...
  82. ncbi Perceived social isolation in a community sample: its prevalence and correlates with aspects of peoples' lives
    Graeme Hawthorne
    Dept of Psychiatry, The University of Melbourne, Level 1 North, Royal Melbourne Hospital, Grattan Street, Parkville, Victoria 3050, Australia
    Soc Psychiatry Psychiatr Epidemiol 43:140-50. 2008
    Although there are many studies reporting perceived social isolation or loneliness and their correlates in specific groups, there are few modern prevalence studies...
  83. ncbi Cross-national comparisons of social isolation and loneliness: introduction and overview
    Jenny de Jong Gierveld
    Netherlands Interdisciplinary Demographic Institute for Advanced Study in the Humanities and Social Sciences, The Hague
    Can J Aging 23:109-13. 2004
    This article provides an introduction to the special volume on research related to issues of social isolation and loneliness for older people...
  84. ncbi Behavioral phenotype of the reeler mutant mouse: effects of RELN gene dosage and social isolation
    Walter L Salinger
    Department of Psychology, University of North Carolina at Greensboro, 27402 6170, USA
    Behav Neurosci 117:1257-75. 2003
    ..These results reveal no effect of Reln gene dosage and provide significant challenges to both the Reln and the neurodevelopmental hypotheses of the etiology of major psychopathologies...
  85. ncbi Social isolation and health, with an emphasis on underlying mechanisms
    John T Cacioppo
    Department of Psychology, University of Chicago, 5848 South University Avenue, Chicago, IL 60637, USA
    Perspect Biol Med 46:S39-52. 2003
    b>Social isolation is a potent but little understood risk factor for morbidity and mortality, and its negative consequences are most profound among the elderly, the poor, and minorities, some of the fastest growing segments of the U.S...
  86. ncbi Social isolation prevents exercise-induced proliferation of hippocampal progenitor cells in female rats
    J Leigh Leasure
    Department of Psychology, University of Houston, Houston, TX 77204, USA
    Hippocampus 19:907-12. 2009
    b>Social isolation negatively affects the behavior and health of laboratory rats. Recently, it has been found that social isolation retards exercise-induced neurogenesis in the hippocampal dentate gyrus (DG) of male rats (Stranahan et al...
  87. pmc Regulation of anxiety and initiation of sexual behavior by CREB in the nucleus accumbens
    Michel Barrot
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 102:8357-62. 2005
    ..other behavioral disturbances such as anxiety-like behaviors can be observed in animals that have undergone social isolation, especially in species having important social interactions...
  88. pmc Corticotropin-releasing factor receptor antagonism within the dorsal raphe nucleus reduces social anxiety-like behavior after early-life social isolation
    Jodi Lukkes
    University of South Dakota, Vermillion, 57069, USA
    J Neurosci 29:9955-60. 2009
    b>Social isolation of rats during the early part of development increases social anxiety-like behavior in adulthood...
  89. ncbi Differential effects of social isolation upon body weight, food consumption, and responsiveness to novel and social environment in bombesin receptor subtype-3 (BRS-3) deficient mice
    K Yamada
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo, Japan
    Physiol Behav 68:555-61. 2000
    The effects of social isolation on body weight gain, food consumption, and responsiveness to novel and social environment were assessed in an animal model for obesity, bombesin receptor subtype-3 (BRS-3) deficient mice...
  90. ncbi Performance of an abbreviated version of the Lubben Social Network Scale among three European community-dwelling older adult populations
    James Lubben
    School of Social Work, Boston College, Chestnut Hill, MA, USA
    Gerontologist 46:503-13. 2006
    There is a need for valid and reliable short scales that can be used to assess social networks and social supports and to screen for social isolation in older persons.
  91. ncbi Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
    Olivier Berton
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Science 311:864-8. 2006
    ..These results establish an essential role for BDNF in mediating long-term neural and behavioral plasticity in response to aversive social experiences...
  92. ncbi Social contacts and their relationship to loneliness among aged people - a population-based study
    Pirkko E Routasalo
    Department of Nursing Science, University of Turku, Finland
    Gerontology 52:181-7. 2006
    Emotional loneliness and social isolation are major problems in old age. These concepts are interrelated and often used interchangeably, but few studies have investigated them simultaneously thus trying to clarify their relationship.
  93. ncbi Chronic sorrow in the HIV-positive patient: issues of race, gender, and social support
    Bronwen Lichtenstein
    Department of Sociology, University of Alabama at Birmingham, Birmingham, Alabama 35294 3350, USA
    AIDS Patient Care STDS 16:27-38. 2002
    ..indicated that chronic sorrow in HIV-positive persons is related to illness, fear of death, poverty, and social isolation, especially for women with children...
  94. ncbi Loneliness and neuroendocrine, cardiovascular, and inflammatory stress responses in middle-aged men and women
    Andrew Steptoe
    Psychobiology Group, Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1E 6BT, UK
    Psychoneuroendocrinology 29:593-611. 2004
    Loneliness is a psychological experience related to social isolation and perceived lack of companionship, and may be relevant to health risk...
  95. ncbi Fear and social isolation as consequences of tuberculosis in VietNam: a gender analysis
    N H Long
    Health Policy Unit, Ministry of Health, Hanoi, Viet Nam
    Health Policy 58:69-81. 2001
    ..The study was conducted in four districts in different regions of Vietnam...
  96. pmc Depression-like behavior and stressor-induced neuroendocrine activation in female prairie voles exposed to chronic social isolation
    Angela J Grippo
    Department of Psychiatry and Brain Body Center, University of Illinois at Chicago, Chicago, IL 60612, USA
    Psychosom Med 69:149-57. 2007
    ..In this study, we hypothesized that social isolation in female prairie voles would induce depression-relevant behaviors and alter their neuroendocrine responses ..
  97. ncbi A model of gene-environment interaction reveals altered mammary gland gene expression and increased tumor growth following social isolation
    J Bradley Williams
    The University of Chicago, 5841 South Maryland Avenue, MC 2115, Chicago, IL 60637, USA
    Cancer Prev Res (Phila) 2:850-61. 2009
    ..that social support improves the outcome of cancer patients, whereas epidemiologic studies suggest that social isolation increases the risk of death associated with several chronic diseases...
  98. ncbi Staff and patient perceptions of seclusion: has anything changed?
    Tom Meehan
    The Park, Centre for Mental Health, University of Queensland, Wacol, Queensland, Australia
    J Adv Nurs 47:33-8. 2004
    ..While early research on the topic highlighted significant differences in staff and patient perceptions, there are few recent data to indicate if these differences still exist...
  99. ncbi Effects of social isolation and environmental enrichment on atherosclerosis in ApoE-/- mice
    Evelina Bernberg
    Department of Molecular and Clinical Medicine Clinical Physiology, Institute of Medicine, The Sahlgrenska Academy, Götenborg University, Goteborg, Sweden
    Stress 11:381-9. 2008
    ..05). Thus, social isolation increased atherosclerosis and plasma lipids in ApoE-/- mice...
  100. ncbi Escape loneliness by going digital: a quantitative and qualitative evaluation of a Dutch experiment in using ECT to overcome loneliness among older adults
    T Fokkema
    Netherlands Interdisciplinary Demographic Institute NIDI, The Hague, The Netherlands
    Aging Ment Health 11:496-504. 2007
    ....
  101. ncbi A review of agitation in mental illness: treatment guidelines and current therapies
    Stephen R Marder
    Department of Psychiatry, David Geffen School of Medicine at the University of California Los Angeles, VISN 22 Mental Illness Research, Education, and Clinical Center, Los Angeles, Calif, USA
    J Clin Psychiatry 67:13-21. 2006
    ..Agitation is an important therapeutic target in the acute and/or emergent setting, as well as for longer-term care of patients with psychiatric illness...

Research Grants76

  1. Effectivenss of a New Non-Invasive Erectile Support System in Aging Populations
    S ALEXANDER WEINSTOCK; Fiscal Year: 2012
    ..but totally natural condition contributes to feelings of insecurity, depression, abandoning relationships, social isolation, and the diminishment of the quality-of-life for both men and their partners...
  2. Mindfulness Based Stress Reduction as an Adjunctive Treatment for Psoriasis
    Jan A Moynihan; Fiscal Year: 2013
    ..patients commonly suffer from high rates of psychological distress, including depression, anxiety, and social isolation. In the proposed randomized control trial, we will examine the low cost, adjunctive intervention Mindfulness ..
  3. Implantation of physiologically functional bioengineered innervated IAS construct
    Khalil N Bitar; Fiscal Year: 2010
    ..Individuals who are incontinent may experience anxiety about "accidents," depression, social isolation, and social exclusion. The management of incontinence itself is burdensome...
  4. Improving ambulatory community access after paralysis
    Rudi Kobetic; Fiscal Year: 2012
    ..with lower extremity paresis have been associated with increased complications such as injury from falls, social isolation from immobility and decreased quality of life measures...
  5. Light-Alarming Personal Noise Dosimeter System
    ALEXANDER MILOVANOV; Fiscal Year: 2013
    ..Hearing loss results in social isolation, lost productivity, increased injuries, and expenses for workers'compensation and hearing aids...
  6. Ontogenic factors in adolescent-emergent depression and decision-making
    SHANNON LEIGH GOURLEY; Fiscal Year: 2013
    ..These outcomes may relate to the effects of adversity-such as social isolation or stress hormone exposure- on the prefrontal cortex, which reaches full structural maturity only at the end ..
  7. System for Tracking and Managing Pain (STAMP)
    Wendy A Rogers; Fiscal Year: 2012
    ..Pain and disability that accompany OA often lead to increased risk of depression, social isolation, and sleeplessness, and increased functional decline in older adults...
  8. Social Regulation of Gene Expression
    John T Cacioppo; Fiscal Year: 2013
    ..Recent research has demonstrated that poor mental and physical health outcomes are distally associated with social isolation, are more proximally associated with perceived social isolation, and are not explicable in terms of ..
  9. Improving Preterm Outcomes by Safeguarding Maternal Mental Health
    Michael Silverstein; Fiscal Year: 2013
    ..care;improve mothers'perceptions of mastery, and decrease their perceptions of caregiver burden and social isolation;and improve mothers'sensitivity to infant cues...
  10. Inflammation, Stress, and Social Behavior: Using Ecological Assessments and Model
    Charles Raison; Fiscal Year: 2012
    ..Conversely, negative social processes (NSP)-whether measured as loneliness, social isolation or interpersonal conflict-predict disease development and concomitant increases in disease-related morbidity ..
  11. The ability of the transcription factor CREB in the Nac to regulate mood
    Ronald S Duman; Fiscal Year: 2011
    ..Conversely, reduced CREB function, caused by a lack of emotional stimulation (e.g., prolonged social isolation), has the opposite effect...
  12. Control of motility in the internal anal sphincter
    Kathleen D Keef; Fiscal Year: 2013
    ..Dysfunction of the IAS leads to substantial social isolation, loss of employment, and institutionalization as well as extracting billions of dollars in health care costs ..
  13. Hearing Loss and Aging
    Frank R Lin; Fiscal Year: 2013
    ..will use four established prospective datasets to study the effects of hearing loss on domains of cognition, social isolation, dementia, functional decline, health care expenditures, and mortality...
  14. Synaptic and Behavioral Correlates of Early Life Stress in the BLA
    Mary Jane Skelly; Fiscal Year: 2013
    ..by investigating, for the first time, the effects of chronic developmental stress in the form of adolescent social isolation on inhibitory adrenoreceptor (AR) signaling in the basolateral amygdala (BLA)...
  15. Sleep and Health in the Social Environment
    Michael A Grandner; Fiscal Year: 2013
    ..respondents'address) of neighborhood variables, including population density, socioeconomic status, social isolation, traffic, noise, an crime/violence, and whether external sources of information predict sleep duration over ..
  16. Architectural Design of the Pelvic Floor Skeletal Muscles
    Marianna Alperin; Fiscal Year: 2013
    ..Their impact on women is significant, causing pelvic pain, sexual dysfunction, social isolation, depression, and poor body image...
  17. STRESS PATHWAYS IN AGE-RELATED HEARING LOSS
    Jochen Schacht; Fiscal Year: 2009
    Presbycusis, age-related hearing loss, is a major reason for social isolation and loss of quality of life in the elderly but we have neither a clear understanding of the mechanisms involved nor of strategies to prevent it...
  18. Early Life Stress and Corticosterone Signaling: Relation to Ethanol Drinking
    TRACY RENEE BUTLER; Fiscal Year: 2013
    ..and corticosterone (CORT) in a well-established model of chronic early life stress produced by adolescent social isolation (SI)...
  19. Identifying brain mediators distinguishing eustress and distress impact on cancer
    Lei Cao; Fiscal Year: 2013
    ..studies have revealed that social support is linked to improved health outcomes among cancer patients whereas social isolation predicts risk for mortality...
  20. In vitro tools for preclinical analysis of cognitive therapies for schizophrenia
    KRISTEN RICHARDSON; Fiscal Year: 2012
    ..are classified into three categories: positive (delusions and hallucinations), negative (flattened affect, social isolation) and cognitive (impaired attention, executive function, working memory)...
  21. Genetic studies of vitiligo
    RICHARD ANDREW SPRITZ; Fiscal Year: 2013
    ..Striking skin depigmentation in GV particularly impacts persons of color, with frequent social isolation and psychiatric co- morbidity...
  22. Effect of Genetic, Individual &Neighborhood Factors on Telomere Length
    Shannon Lynch; Fiscal Year: 2013
    ..However, neighborhood level factors (social isolation, structural decline, violence, etc) represent an important consideration for aging studies since they have ..
  23. Development of Mental Health Treatment for Obstetric Fistula Patients
    Melissa H Watt; Fiscal Year: 2013
    ..Multiple studies have documented the social and psychological impact of obstetric fistula, which includes social isolation, stigma, depression, and mental health dysfunction...
  24. Reducing Violence and HIV Risk Among War-Exposed Liberian Youth
    Nathan B Hansen; Fiscal Year: 2013
    ..abstract_text> ..
  25. Mechanism-based, pro-cognitive therapies for schizophrenia
    DAVID JULIAN GERBER; Fiscal Year: 2010
    ..into three categories: positive symptoms, including hallucinations and delusions;negative symptoms, such as social isolation and flattened affect;and cognitive symptoms, which include impaired attention and working memory...
  26. Momba: A smartphone application to promote the mental health of new mothers
    MEGAN VEENEMA SMITH; Fiscal Year: 2013
    ..Known risk factors among women include low-income, single marital status, adolescent parenting, and social isolation. Although racial and ethnic minority status, per se, do not increase risk of major depressive disorder, ..
  27. CBPR on Active Living and Recovery for Racial/Ethnic Groups with Mental Illness
    Yoshitaka Iwasaki; Fiscal Year: 2010
    ..g., social isolation, obesity)...
  28. Oxytocin's novel antianxiety effect
    Jeffrey B Rosen; Fiscal Year: 2012
    ..Oxytocin also reduces exaggerated startle produced by social isolation demonstrating that oxytocin promotes social resiliency...
  29. The Wisconsin Longitudinal Study: As We Age
    Pamela Herd; Fiscal Year: 2012
    ..care system;social and civic participation, exchange relationships, intellectual and social engagement, and social isolation;and medical, legal, religious, and psychological preparations for the end of life...
  30. Self-Regulation Failure, Disordered Eating and Overweight in Youth
    LORI ANNE FRANCIS; Fiscal Year: 2010
    ..several studies provide evidence for psychological correlates including depression, anxiety, loneliness, and social isolation. The findings from the proposed study may provide information that informs the design of programs to reduce ..
  31. Psychological stress, associate biologic mediators, and ovarian cancer risk
    Shelley S Tworoger; Fiscal Year: 2013
    ..distress (anxiety, depressive symptoms) and psychosocial stressors (care-giving stress, job strain, social isolation), with risk of ovarian cancer in over 950 prospectively-collected cases from the Nurses'Health Study ..
  32. Functional Architecture of Human Speech Motor Cortex
    Edward Chang; Fiscal Year: 2011
    ..profound paralysis due to trauma, stroke, or disease is loss of the ability to speak, which leads to profound social isolation. Our research focuses on novel methodologies gained in previous studies of speech perception in the human ..
  33. In vivo methods for preclinical analysis of cognitive therapies for schizophrenia
    JONATHAN MAX LEVENSON; Fiscal Year: 2010
    ..can be grouped into three categories: positive symptoms, such as hallucinations;negative symptoms, such as social isolation and inappropriate emotional response;and cognitive symptoms...
  34. MODEL OF HYPERCORTISOLISM FOR MAJOR DEPRESSION
    Alan F Schatzberg; Fiscal Year: 2010
    ..normal distribution) determined before initiation of the study will respond to repeated exposure to cycles of social isolation-induced hypercortisolism with impaired spatial memory, increased anhedonia, and HPA-axis dysregulation as ..
  35. Positive Emotional Processing: Exploring Novel Treatment Targets in Social Phobia
    Charles Taylor; Fiscal Year: 2012
    ..g., Folkman &Moskowitz, 2000;Lyubomirsky et al., 2005). In contrast, limited social ties and social isolation are associated with increased morbidity and risk of mortality (e.g., Cacioppo et al., 2003;House et al...
  36. Mechanisms of Social Isolation and Environmental Enrichment in an Animal Model
    Angela J Grippo; Fiscal Year: 2012
    ..environmental enrichment), for preventing the negative emotional and cardiovascular consequences of social isolation in the context of depression and heart disease...
  37. Efficacy of Voice Treatment for Parkinson's Disease
    Lorraine O Ramig; Fiscal Year: 2011
    ..Improving communication in people with IPD can have a positive impact on quality of life and prevent social isolation. Virtually every individual with idiopathic Parkinson disease (IPD) will have problems related to ..
  38. NEURAL NETWORKS FOR SPEECH PERCEPTION IN NOISE
    Lee M Miller; Fiscal Year: 2010
    ..Among the 30 million Americans with hearing loss, many suffer depression and social isolation because of their difficulty communicating...
  39. Kinesia-D: Ambulatory PD Dyskinesia Monitor for Drug Therapy Titration
    THOMAS OLIVER MERA; Fiscal Year: 2013
    ..LID significantly impact quality of life through exhaustion and fatigue, social isolation, and depression. Healthcare costs are substantially greater with increased LID severity...
  40. Health Inequalities: Social Isolation Among Rural Latinos
    Jeanne Marie R Stacciarini; Fiscal Year: 2013
    ..rural populations which can lead to the development of related health policy, (2) understand the role of social isolation in th cultural adaptation of rural Latino families in order to develop culturally relevant interventions, (3) ..
  41. Neuroimmune Mechanisms of Risk and Resilience to Maladaptive Responses to Stress
    Leonardo H Tonelli; Fiscal Year: 2013
    ..and RAG2-/- mice reconstituted with T cells will be evaluated in the learned helplessness paradigm or in the social isolation model of stress...
  42. Minority Stress, Alcohol Use, and Intimate Partner Violence Among Lesbians
    Robin J Lewis; Fiscal Year: 2012
    ..Four constructs will be tested as mediators: Coping/Emotional Regulation (i.e., social isolation, rumination, suppression), Stigma-Related Processes (i.e...
  43. Cardiovascular disease, depression, and oxytocin
    MELISSA SCOTTI; Fiscal Year: 2013
    ..behavioral, neuroendocrine, and cardiovascular responses to a species-relevant and translational stressor, social isolation. Like humans, prairie voles develop negative affective behaviors (relevant to depression and anxiety) when ..
  44. The protective effect of oxytocin on social isolation: physiological mechanisms
    JASON RICHARD YEE; Fiscal Year: 2011
    ..This work seeks to understand: the underlying physiological mechanisms in order to guide both behavioral and pharmacological efforts to prevent disease and promote health in the elderly. ..
  45. HIV Risk among Latino Day Laborers: Structural, Social, and Individual Factors
    Fernanda T Bianchi; Fiscal Year: 2010
    ..g., to create opportunities to build bonds and thereby lessen social isolation and loneliness), and policies enacted by government (e.g., to improve access to health services)...
  46. Social perception and social communication in adults with traumatic brain injury
    Lyn S Turkstra; Fiscal Year: 2013
    ..These problems can lead to loss of employment and social isolation, which in turn are associated with a high risk of depression, suicidal ideation, and poor quality of life ..
  47. Development of an Intervention for Non-Suicidal Self-Injury in Young Adults
    Margaret S Andover; Fiscal Year: 2012
    ..including physical injury ranging in medical severity, distress from shame associated with the behavior, social isolation, psychological symptoms, and increased risk and lethality of NSSI over time, resulting in more severe ..
  48. Socially-facilitated excessive alcohol drinking in a novel prairie vole model
    ALLISON MJ ANACKER; Fiscal Year: 2012
    ..apos;low drinkers,'designated as such during a two-bottle choice test with water and 10% alcohol in social isolation. The alcohol intake of each animal will be monitored using a lickometer system, to determine whether the ..
  49. Cues from touch to aid posture and gait in individuals with Parkinson's disease
    Ely Rabin; Fiscal Year: 2010
    ..and gait, and leads to falling which contributes to reduced activity, reduced quality of life, depression, social isolation and mortality...
  50. Spatial Patterns of Social Isolation, Youthful Marijuana Use, and Sexual/HIV Risk
    Ruth D Peterson; Fiscal Year: 2010
    ..of the impact of neighborhood exposure is theoretically defining and empirically exploring the concept of social isolation as evident in space- time activity patterns at both the individual and neighborhood levels, and exploring the ..
  51. A microfinance intervention to improve health of rape survivors in the DRC
    NANCY E GLASS; Fiscal Year: 2013
    ..of these efforts are limited by gaps in knowledge of the role of social determinants, such as poverty, social isolation, chronic stress and trauma, and limited access to health care services has on disparities in health...
  52. Visual psychophysics of human face processing
    Ken Nakayama; Fiscal Year: 2012
    ..It can be severely disabling, leading to lost friendships and job opportunities and for some, depression and social isolation. We propose to develop behavioral tests to diagnose and characterize prosopagnosia in adults and in children...
  53. Synaptic and Behavioral Correlates of Adeonsinergic Signaling in the BLA
    Andrew Ryan Rau; Fiscal Year: 2013
    ..This aim will also test the hypothesis that adenosinergic tone is disrupted following adolescent social isolation, a model of early life stress that engenders increases in anxiety-like behavior as well as increases in ..
  54. Using ICTs to Enhance Quality of Life Among Older Adults: An Intervention Study
    Shelia R Cotten; Fiscal Year: 2013
    ..Significance: Depression, physical health decline, loneliness, and social isolation are key issues of concern for older adults...
  55. Social and Neural Bases of Vulnerability to Fraud in Older Adults
    Shelley E Taylor; Fiscal Year: 2012
    ..Taken together, the studies explore how: social isolation;declines in older adults'ability to decode deceit and recognize cues of untrustworthiness;an ..
  56. Social Environment, Sympathetic Nervous System &Atherosclerosis in WHHL Rabbits
    Philip M McCabe; Fiscal Year: 2013
    ..that animals in stable relationships with littermates, as opposed to WHHLs in unstable social conditions or social isolation, showed a significant decrease in the progression of atherosclerosis...
  57. New Neurons in the Adult Amygdala
    Zuoxin Wang; Fiscal Year: 2013
    ..adult-generated cells, their rates of proliferation were facilitated by social interactions and diminished by social isolation, and treatment of an antimitotic drug reduced new neurons in the amygdala and inhibited social attachment ..
  58. Psychosocial Stress and Behavioral Response to Stroke
    LOUISE DEBORAH MCCULLOUGH; Fiscal Year: 2013
    ..In contrast, perceived social isolation predicts morbidity and mortality from cerebrovascular disease...
  59. The effects of social deprivation on socio-cognitive functioning
    Jason P Mitchell; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Social isolation has considerable effects on human functioning...
  60. Identifying mechanisms linking stress biology to human breast cancer
    MARTHA KENT MCCLINTOCK; Fiscal Year: 2013
    ..We discovered that chronic social isolation leads to a heightened glucocorticoid response to a superimposed stressor;in turn, mammary gland gene ..
  61. De la Mano con la Salud (Lend A Hand for Helath): A Male Lay Health Advisor Netwo
    PATRICIA ISABEL DOCUMET; Fiscal Year: 2012
    ..because there are few services that address their cultural and language needs and because they face more social isolation. There are no published health promotion efforts using promotores in NGC...
  62. Addressing Social Determinants to Reduce Refugee Mental Health Disparities
    Jessica R Goodkind; Fiscal Year: 2013
    ..meaningful social roles by valuing refugees'culture, experiences, and knowledge;d) reduce refugees'social isolation;and e) increase communities'responsiveness to refugees...
  63. A Rodent Model of TBI Suffered During Sustained Combat Operations
    RONALD RIECHERS; Fiscal Year: 2009
    ..will be randomized to one of the following conditions for 24 hours prior to surgery: REM sleep deprived, social isolation, normal rat laboratory environment. Baseline neurobehavioral testing will be completed in all rats...
  64. RISK FACTORS FOR YOUNG ADULT HODGKIN'S DISEASE IN TWINS
    Wendy Cozen; Fiscal Year: 2004
    ..The etiologic mechanism may involve relative social isolation and protection from exposure to common childhood infections, leading to increased susceptibility later in the ..
  65. TELEMEDICINE FOR RURAL AND PSYCHIATRIC CLIENTS
    CHRISTINE PEDERSON; Fiscal Year: 2001
    b>Social isolation and inadequate information are significant barriers to recovery for persons with serious mental disorders (SMI), particularly for those living in rural areas...
  66. VIOLENCE AND SPONTANEOUS ABORTION IN INNER CITY WOMEN
    Deborah Nelson; Fiscal Year: 2002
    ..and descriptive, characterizing cases and controls by current or past violence, age, substance abuse, social isolation. The primary analysis will be logistic regression, with odds ratios and 95% confidence intervals...
  67. Tai Chi Chih: Complementary Use to Achieve Remission in Geriatric Depression
    Helen Lavretsky; Fiscal Year: 2009
    ..of patients are left with significant residual symptoms, putting them at risk of chronic illness, frailty, social isolation, and suicide...
  68. EXPERIENCE DEPENDENT CHANGES IN THE BRAIN
    David Clayton; Fiscal Year: 2003
    ..have not yet begun the process of song learning, or to older birds who were reared under conditions of severe social isolation. In the past project, this to older birds who were reared under conditions of severe social isolation...
  69. Quality of Life Intervention in Advanced Prostate Cancer
    Frank Penedo; Fiscal Year: 2006
    ..for localized prostate cancer, we have shown that (a) psychosocial factors such as distress, depression, social isolation, coping and perceived stress are related to poor quality of life, and that (b) a ten-week, group-based ..
  70. INFORMATION CHANNELS IN THE VESTIBULAR NERVE
    ELLENGENE PETERSON; Fiscal Year: 2000
    ..associated with deficits in postural regulation and are common sequelae of aging, contributing to dependence, social isolation, and depression...
  71. WORK RETIREMENT AND DRINKING AMONG BLUE COLLAR WORKERS
    Samuel Bacharach; Fiscal Year: 2009
    ..The purpose of the research is to examine how different levels of social isolation (i.e...
  72. Analysis and Remediation of Language Production
    RITA BERNDT; Fiscal Year: 2007
    ..with language represents, in most cases, a catastrophic loss of self-sufficiency and a source of profound social isolation. No treatment for aphasia reported to date has reliably brought about changes in language production that ..
  73. Improving Access to Early Parent Education and Support
    CAROL METZLER; Fiscal Year: 2006
    ..transition to parenthood is a difficult one for many parents, however, and can lead to parental stress and social isolation and to lack of parenting competence and confidence...
  74. TLC TELEPHONE SYSTEM FOR ALZHEIMERS FAMILY CAREGIVERS
    Diane Mahoney; Fiscal Year: 2001
    ..make recommendations and referrals if necessary, 2) provide a voice-mail caregiver support network to reduce social isolation, 3) provide an bask the expert call option for recalcitrant caregiving problems, and 4) offer a distraction ..
  75. Telephone Counseling for Head and Neck Cancer
    Kristin Kilbourn; Fiscal Year: 2006
    ..Additionally, many HNC patients suffer from high levels of distress and social isolation. The transactional model predicts that those who are able to handle and adapt to illness-related stressors ..
  76. Laryngeal hydration aerosol for prevention of voice disorders
    Kimberly Fisher; Fiscal Year: 2007
    ..has largely failed to prevent disorders so that voice loss contributes substantially to job absenteeism and social isolation. Our goal is to promote vocal fold tissue defenses against disease and injury, thereby preventing voice ..