quality of life

Summary

Summary: A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.

Top Publications

  1. ncbi Interpreting SF-36 summary health measures: a response
    J E Ware
    Quality Metric, Inc, Lincoln, RI 02865, USA
    Qual Life Res 10:405-13; discussion 415-20. 2001
  2. ncbi Pulmonary Rehabilitation: Joint ACCP/AACVPR Evidence-Based Clinical Practice Guidelines
    Andrew L Ries
    University of California, San Diego, Department of Pulmonary and Critical Care Medicine, UCSD Medical Center, 200 West Arbor Dr, San Diego, CA 92103 8377, USA
    Chest 131:4S-42S. 2007
  3. ncbi Translation, validation, and norming of the Dutch language version of the SF-36 Health Survey in community and chronic disease populations
    N K Aaronson
    Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Amsterdam
    J Clin Epidemiol 51:1055-68. 1998
  4. ncbi Swedish population health-related quality of life results using the EQ-5D
    K Burstrom
    Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden
    Qual Life Res 10:621-35. 2001
  5. ncbi EQ-5D: a measure of health status from the EuroQol Group
    R Rabin
    Erasmus University Rotterdam, Centre for Health Policy and Law, The Netherlands
    Ann Med 33:337-43. 2001
  6. ncbi A 4-year trial of tiotropium in chronic obstructive pulmonary disease
    Donald P Tashkin
    David Geffen School of Medicine at the University of California, Los Angeles 90095 1690, USA
    N Engl J Med 359:1543-54. 2008
  7. ncbi Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation
    Geoffrey R Norman
    Program for Educational Research and Development, McMaster University, Hamilton, ON, Canada
    Med Care 41:582-92. 2003
  8. pmc Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L)
    M Herdman
    Insight Consulting and Research, 08301 Mataró, Spain
    Qual Life Res 20:1727-36. 2011
  9. ncbi American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation
    Linda Nici
    Am J Respir Crit Care Med 173:1390-413. 2006
  10. ncbi Development and first validation of the COPD Assessment Test
    P W Jones
    St George s University of London, UK
    Eur Respir J 34:648-54. 2009

Detail Information

Publications280 found, 100 shown here

  1. ncbi Interpreting SF-36 summary health measures: a response
    J E Ware
    Quality Metric, Inc, Lincoln, RI 02865, USA
    Qual Life Res 10:405-13; discussion 415-20. 2001
    ..sf-36.com/test...
  2. ncbi Pulmonary Rehabilitation: Joint ACCP/AACVPR Evidence-Based Clinical Practice Guidelines
    Andrew L Ries
    University of California, San Diego, Department of Pulmonary and Critical Care Medicine, UCSD Medical Center, 200 West Arbor Dr, San Diego, CA 92103 8377, USA
    Chest 131:4S-42S. 2007
    ....
  3. ncbi Translation, validation, and norming of the Dutch language version of the SF-36 Health Survey in community and chronic disease populations
    N K Aaronson
    Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Amsterdam
    J Clin Epidemiol 51:1055-68. 1998
    ..On-going studies will generate data on the responsiveness of the SF-36 to within-group changes in health over time. Efforts are underway to translate and validate the questionnaire for use among ethnic minority groups in the Netherlands...
  4. ncbi Swedish population health-related quality of life results using the EQ-5D
    K Burstrom
    Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden
    Qual Life Res 10:621-35. 2001
    Health-related quality of life (HRQoL) measured on population level may be useful to guide policies for health...
  5. ncbi EQ-5D: a measure of health status from the EuroQol Group
    R Rabin
    Erasmus University Rotterdam, Centre for Health Policy and Law, The Netherlands
    Ann Med 33:337-43. 2001
    ..EQ-5D has now been translated into most major languages with the EuroQol Group closely monitoring the process...
  6. ncbi A 4-year trial of tiotropium in chronic obstructive pulmonary disease
    Donald P Tashkin
    David Geffen School of Medicine at the University of California, Los Angeles 90095 1690, USA
    N Engl J Med 359:1543-54. 2008
    ..Previous studies showing that tiotropium improves multiple end points in patients with chronic obstructive pulmonary disease (COPD) led us to examine the long-term effects of tiotropium therapy...
  7. ncbi Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation
    Geoffrey R Norman
    Program for Educational Research and Development, McMaster University, Hamilton, ON, Canada
    Med Care 41:582-92. 2003
    A number of studies have computed the minimally important difference (MID) for health-related quality of life instruments.
  8. pmc Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L)
    M Herdman
    Insight Consulting and Research, 08301 Mataró, Spain
    Qual Life Res 20:1727-36. 2011
    ..This article introduces the new 5-level EQ-5D (EQ-5D-5L) health status measure...
  9. ncbi American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation
    Linda Nici
    Am J Respir Crit Care Med 173:1390-413. 2006
  10. ncbi Development and first validation of the COPD Assessment Test
    P W Jones
    St George s University of London, UK
    Eur Respir J 34:648-54. 2009
    ..Current health-related quality of life questionnaires provide valid assessment of COPD, but are complex, which limits routine use...
  11. ncbi Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    Herbert Hurwitz
    Duke University, Durham, NC, USA
    N Engl J Med 350:2335-42. 2004
    ..Bevacizumab, a monoclonal antibody against vascular endothelial growth factor, has shown promising preclinical and clinical activity against metastatic colorectal cancer, particularly in combination with chemotherapy...
  12. ncbi Principles of Good Practice for the Translation and Cultural Adaptation Process for Patient-Reported Outcomes (PRO) Measures: report of the ISPOR Task Force for Translation and Cultural Adaptation
    Diane Wild
    Oxford Outcomes Ltd, Cassington, Oxford, UK
    Value Health 8:94-104. 2005
    In 1999, ISPOR formed the Quality of Life Special Interest group (QoL-SIG)--Translation and Cultural Adaptation group (TCA group) to stimulate discussion on and create guidelines and standards for the translation and cultural adaptation ..
  13. ncbi Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment
    Harald Breivik
    University of Oslo, Faculty of Medicine, Faculty Division Rikshospitalet, Department of Anaesthesiology, Rikshospitalet University Hospital, Norway
    Eur J Pain 10:287-333. 2006
    ..Forty percent had inadequate management of their pain. Interesting differences between countries were observed, possibly reflecting differences in cultural background and local traditions in managing chronic pain...
  14. ncbi PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations
    J W Varni
    Center for Child Health Outcomes, Children s Hospital and Health Center, San Diego, California, USA
    Med Care 39:800-12. 2001
    The PedsQL (Pediatric Quality of Life Inventory) (Children's Hospital and Health Center, San Diego, California) is a modular instrument for measuring health-related quality of life (HRQOL) in children and adolescents ages 2 to 18...
  15. pmc The COSMIN checklist for assessing the methodological quality of studies on measurement properties of health status measurement instruments: an international Delphi study
    Lidwine B Mokkink
    Department of Epidemiology and Biostatistics and the EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    Qual Life Res 19:539-49. 2010
    ..We present the COSMIN checklist and the agreement of the panel on the items of the checklist...
  16. ncbi Quality of life and satisfaction with outcome among prostate-cancer survivors
    Martin G Sanda
    Departments of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Harvard University, Boston, MA 02215, USA
    N Engl J Med 358:1250-61. 2008
    We sought to identify determinants of health-related quality of life after primary treatment of prostate cancer and to measure the effects of such determinants on satisfaction with the outcome of treatment in patients and their spouses ..
  17. ncbi The estimation of a preference-based measure of health from the SF-12
    John E Brazier
    Health Economics and Decision Science Group, School of Health and Related Research, University of Sheffield, Sheffield, United Kingdom
    Med Care 42:851-9. 2004
    The SF-12 is a multidimensional generic measure of health-related quality of life. It has become widely used in clinical trials and routine outcome assessment because of its brevity and psychometric performance, but it cannot be used in ..
  18. ncbi The World Health Organization's WHOQOL-BREF quality of life assessment: psychometric properties and results of the international field trial. A report from the WHOQOL group
    S M Skevington
    WHO Centre for the Study of Quality of Life, Department of Psychology, University of Bath, Bath, UK
    Qual Life Res 13:299-310. 2004
    b>Quality of life (QOL) assessments that are easily administered and which do not impose a great burden on the respondent are needed for use in large epidemiological surveys, clinical settings and clinical trials...
  19. ncbi Interpreting the significance of changes in health-related quality-of-life scores
    D Osoba
    British Columbia Cancer Agency and University of British Columbia, Vancouver, Canada
    J Clin Oncol 16:139-44. 1998
    To determine the significance to patients of changes in health-related quality-of-life (HLQ) scores assessed by the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ-C30).
  20. ncbi The development of a walkability index: application to the Neighborhood Quality of Life Study
    L D Frank
    School of Community and Regional Planning, University of British Columbia, 231 1933 West Mall, Vancouver, British Columbia, Canada V6T 1Z2
    Br J Sports Med 44:924-33. 2010
    ..Validity of the walkability index is examined through travel surveys among areas examined in the Neighborhood Quality of Life Study (NQLS), a study investigating built environment correlates of adults' physical activity.
  21. ncbi Causes and consequences of comorbidity: a review
    R Gijsen
    National Institute of Public Health and the Environment, P O Box 1, 3720 BA, Bilthoven, The Netherlands
    J Clin Epidemiol 54:661-74. 2001
    ..We found comorbidity in general to be associated with mortality, quality of life, and health care. The consequences of specific disease combinations, however, depended on many factors...
  22. ncbi Physical activity in patients with COPD
    H Watz
    Pulmonary Research Institute Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, Woehrendamm 80, Grosshansdorf, Germany
    Eur Respir J 33:262-72. 2009
    ..Clinical characteristics of patients with chronic obstructive pulmonary disease only incompletely reflect their physical activity...
  23. pmc Managing multiple chronic conditions: a strategic framework for improving health outcomes and quality of life
    Anand K Parekh
    U S Department of Health and Human Serivices, Office of the Assistant Secretary for Health, 200 Independence Ave SW, Washington, DC 20201, USA
    Public Health Rep 126:460-71. 2011
    ..outlines national strategies for maximizing care coordination and for improving health and quality of life for individuals with MCC...
  24. pmc Development, validity and responsiveness of the Clinical COPD Questionnaire
    Thys van der Molen
    Department of General Practice, University of Groningen, Groningen, The Netherlands
    Health Qual Life Outcomes 1:13. 2003
    ..So far no validated questionnaires are available to measure symptom and functional state in daily clinical practice. The aim of this study was to develop and validate the Clinical COPD Questionnaire (CCQ)...
  25. ncbi [Measuring the quality of life in economic evaluations: the Dutch EQ-5D tariff]
    L M Lamers
    Instituut Beleid en Management Gezondheidszorg, Erasmus MC, Postbus 1738, 3000 DR Rotterdam
    Ned Tijdschr Geneeskd 149:1574-8. 2005
    ..To value EQ-5D health states by a general Dutch public. EQ-5D is a standardised questionnaire that is used to calculate quality-adjusted life-years for cost-utility analysis...
  26. pmc The Hospital Anxiety And Depression Scale
    R Philip Snaith
    Senior Lecturer in Psychiatry, University of Leeds, 21 Gledhow Wood Road, Leeds LS8 4BW, UK
    Health Qual Life Outcomes 1:29. 2003
    ..It should be emphasised that self-assessment scales are only valid for screening purposes; definitive diagnosis must rest on the process of clinical examination...
  27. ncbi Physical activity level and health-related quality of life in the general adult population: a systematic review
    Raphael Bize
    Centre for Health Promotion Studies, School of Public Health, University of Alberta, Edmonton, Canada
    Prev Med 45:401-15. 2007
    Little is known regarding health-related quality of life and its relation with physical activity level in the general population. Our primary objective was to systematically review data examining this relationship.
  28. ncbi Integrating response shift into health-related quality of life research: a theoretical model
    M A Sprangers
    Department of Medical Psychology, Academic Hospital Amsterdam, University of Amsterdam, The Netherlands
    Soc Sci Med 48:1507-15. 1999
    ..process is 'response shift' which involves changing internal standards, values and the conceptualization of quality of life (QOL)...
  29. ncbi Comparison of the minimally important difference for two health state utility measures: EQ-5D and SF-6D
    Stephen J Walters
    Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK
    Qual Life Res 14:1523-32. 2005
    ..Empirical work is required to determine what the smallest change is in utility scores that can be regarded as important and whether this change in utility value is constant across measures and conditions...
  30. ncbi Interim scoring for the EQ-5D-5L: mapping the EQ-5D-5L to EQ-5D-3L value sets
    Ben van Hout
    University of Sheffield, Sheffield, UK
    Value Health 15:708-15. 2012
    ..The objective of this study was to develop values sets for the EQ-5D-5L by means of a mapping ("crosswalk") approach to the currently available three-level version of the EQ-5D (EQ-5D-3L) values sets...
  31. ncbi The impact of non-motor symptoms on health-related quality of life of patients with Parkinson's disease
    Pablo Martinez-Martin
    Area of Applied Epidemiology, National Centre of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain
    Mov Disord 26:399-406. 2011
    Non-motor symptoms are detrimental to health-related quality of life (HRQoL) of Parkinson's disease patients...
  32. ncbi Properties of the COPD assessment test in a cross-sectional European study
    P W Jones
    Division of Clinical Science, St George s University of London, Cranmer Terrace, London SW17 0RE, UK
    Eur Respir J 38:29-35. 2011
    ..8, p<0.0001). The CAT is a simple and easy-to-use questionnaire that distinguishes between patients of different degrees of COPD severity and appears to behave the same way across countries...
  33. ncbi Self-esteem and quality of life in obese children and adolescents: a systematic review
    Lucy J Griffiths
    MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, London, UK l griffi
    Int J Pediatr Obes 5:282-304. 2010
    ..However, none have examined how this affects multi-component assessments of self-esteem and quality of life in young people with defined obesity...
  34. pmc Effect of telehealth on quality of life and psychological outcomes over 12 months (Whole Systems Demonstrator telehealth questionnaire study): nested study of patient reported outcomes in a pragmatic, cluster randomised controlled trial
    Martin Cartwright
    School of Health Sciences, City University London, London EC1A 7QN, UK
    BMJ 346:f653. 2013
    To assess the effect of second generation, home based telehealth on health related quality of life, anxiety, and depressive symptoms over 12 months in patients with long term conditions.
  35. ncbi The Dutch tariff: results and arguments for an effective design for national EQ-5D valuation studies
    L M Lamers
    Institute for Medical Technology Assessment, Erasmus University Medical Center, Rotterdam, The Netherlands
    Health Econ 15:1121-32. 2006
    ..The mean absolute error was 0.030. The design of this study is recommended for national EQ-5D valuation studies...
  36. ncbi The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme
    Poul Erik Petersen
    World Health Organization, Oral Health Programme, Noncommunicable Disease Prevention and Health Promotion, 20 Avenue Appia, 1211 Geneva 27, Switzerland
    Community Dent Oral Epidemiol 31:3-23. 2003
    ..The severe impact in terms of pain and suffering, impairment of function and effect on quality of life must also be considered...
  37. ncbi The PedsQL 4.0 as a pediatric population health measure: feasibility, reliability, and validity
    James W Varni
    Department of Landscape Architecture and Urban Planning, College of Architecture and the Department of Pediatrics, Texas A and M University, College Station, TX 77843, USA
    Ambul Pediatr 3:329-41. 2003
    The application of health-related quality of life (HRQOL) as a pediatric population health measure may facilitate risk assessment and resource allocation, the tracking of community health, the identification of health disparities, and ..
  38. ncbi Health-related quality of life of severely obese children and adolescents
    Jeffrey B Schwimmer
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, School of Medicine, University of California, San Diego 92103, USA
    JAMA 289:1813-9. 2003
    One in 7 US children and adolescents is obese, yet little is known about their health-related quality of life (QOL).
  39. ncbi Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study
    Ulrik Wisløff
    Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Olav Kyrres gt 9, 7489 Trondheim, Norway
    Circulation 115:3086-94. 2007
    ..Our objective was to compare training programs with moderate versus high exercise intensity with regard to variables associated with cardiovascular function and prognosis in patients with postinfarction heart failure...
  40. ncbi Monitoring depression treatment outcomes with the patient health questionnaire-9
    Bernd Löwe
    Department of General Internal and Psychosomatic Medicine, Heidelberg University Medical Center, D 69120 Heidelberg, Germany
    Med Care 42:1194-201. 2004
    ..We investigated responsiveness to treatment, reproducibility, and minimal clinically important difference of the Patient Health Questionnaire-9 (PHQ-9), a standard instrument for diagnosing depression in primary care...
  41. ncbi Long-term mortality and quality of life in sepsis: a systematic review
    Bradford D Winters
    Departments of Anesthesiology and Critical Care Medicine and Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Crit Care Med 38:1276-83. 2010
    ..sepsis are poorly understood, and sepsis in patients may have different long-term effects on mortality and quality of life. Long-term outcome studies of other critical illnesses such as acute lung injury have demonstrated ..
  42. ncbi The effect of obesity on health outcomes
    John B Dixon
    School of Primary Health Care, Monash University, Melbourne, Australia
    Mol Cell Endocrinol 316:104-8. 2010
    ..Obesity has a clearly measurable impact on physical and mental health, health related quality of life, and generates considerable direct and indirect costs...
  43. ncbi A model of equivalence in the cultural adaptation of HRQoL instruments: the universalist approach
    M Herdman
    Catalan Institute of Public Health, Universitat de Barcelona, Spain
    Qual Life Res 7:323-35. 1998
    The health-related quality of life (HRQoL) literature presents a confused picture of what 'equivalence' in the cross-cultural use of HRQoL questionnaires means and how it can be assessed...
  44. ncbi Effects of n-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: a 6-month randomised controlled trial
    Natalie Sinn
    School of Health Sciences, Sansom Institute for Health Research, Nutritional Physiology Research Centre, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia
    Br J Nutr 107:1682-93. 2012
    ..was to investigate the benefits of supplementing a diet with n-3 PUFA, DHA and EPA, for depressive symptoms, quality of life (QOL) and cognition in elderly people with MCI...
  45. pmc Mid-arm muscle circumference and quality of life and survival in maintenance hemodialysis patients
    Nazanin Noori
    Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Clin J Am Soc Nephrol 5:2258-68. 2010
    ..We hypothesized that mid-arm muscle circumference (MAMC), a conveniently measured surrogate of lean body mass (LBM), has stronger association with clinical outcomes than triceps skinfold (TSF), a surrogate of fat mass...
  46. pmc The Knee injury and Osteoarthritis Outcome Score (KOOS): from joint injury to osteoarthritis
    Ewa M Roos
    Department of Orthopaedics, Lund University Hospital, SE 221 85 Lund, Sweden
    Health Qual Life Outcomes 1:64. 2003
    ..Symptoms, Function in daily living (ADL), Function in Sport and Recreation (Sport/Rec), and knee-related Quality of Life (QOL)...
  47. ncbi The Short Form Health Survey (SF-36): translation and validation study of the Iranian version
    Ali Montazeri
    Iranian Institute for Health Sciences Research, Tehran, Iran
    Qual Life Res 14:875-82. 2005
    ..to develop and validate the Iranian version of the Short Form Health Survey (SF-36) for use in health related quality of life assessment in Iran. A culturally comparable questionnaire was developed and pilot tested...
  48. ncbi Exercise-based rehabilitation for patients with coronary heart disease: systematic review and meta-analysis of randomized controlled trials
    Rod S Taylor
    Department of Epidemiology and Public Health, University of Birmingham, Birmingham, United Kingdom
    Am J Med 116:682-92. 2004
    ..To review the effectiveness of exercise-based cardiac rehabilitation in patients with coronary heart disease...
  49. ncbi Quality of life and diabetes
    R R Rubin
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Diabetes Metab Res Rev 15:205-18. 1999
    b>Quality of life is an important health outcome in its own right, representing the ultimate goal of all health interventions...
  50. pmc Estimation of minimally important differences in EQ-5D utility and VAS scores in cancer
    A Simon Pickard
    Center for Pharmacoeconomic Research, Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, USA
    Health Qual Life Outcomes 5:70. 2007
    ..The aim of this study was to provide a range of estimates of minimally important differences (MIDs) in EQ-5D scores in cancer and to determine if estimates are comparable in lung cancer...
  51. ncbi Ferric carboxymaltose in patients with heart failure and iron deficiency
    Stefan D Anker
    Department of Cardiology, Campus Virchow Klinikum, Charite Universitatsmedizin, Berlin
    N Engl J Med 361:2436-48. 2009
    ....
  52. ncbi Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: a report of the V325 Study Group
    Eric Van Cutsem
    University Hospital Gasthuisberg, Leuven, Belgium
    J Clin Oncol 24:4991-7. 2006
    ....
  53. ncbi The unacknowledged impact of chronic schistosomiasis
    Charles H King
    Center for Global Health and Diseases, Case Western Reserve University School of Medicine 10900 Euclid Avenue, Cleveland, Ohio 44106 7286, USA
    Chronic Illn 4:65-79. 2008
    ....
  54. ncbi Depressive symptoms and chronic obstructive pulmonary disease: effect on mortality, hospital readmission, symptom burden, functional status, and quality of life
    Tze Pin Ng
    Gerontological Research Programme, Faculty of Medicine, National University of Singapore, Singapore
    Arch Intern Med 167:60-7. 2007
    ..We evaluated the impact of comorbid depression on mortality, hospital readmission, smoking behavior, respiratory symptom burden, and physical and social functioning in patients with COPD...
  55. ncbi A randomized, controlled trial of surgery for temporal-lobe epilepsy
    S Wiebe
    Department of Clinical Neurological Sciences, University of Western Ontario, and London Health Sciences Centre, Canada
    N Engl J Med 345:311-8. 2001
    ..We conducted a randomized, controlled trial to assess the efficacy and safety of surgery for temporal-lobe epilepsy...
  56. ncbi Disability, HRQoL and resource use among chronic and episodic migraineurs: results from the International Burden of Migraine Study (IBMS)
    A M Blumenfeld
    The Neurology Center, 320 Santa Fe Drive, Encinitas, CA 92024, USA
    Cephalalgia 31:301-15. 2011
    ..In this study, we compared episodic to chronic migraine sufferers to determine if migraine status predicted headache-related disability, health-related quality of life (HRQoL) and health care resource utilization.
  57. pmc Cognitive impairment and preferences for current health
    Joseph T King
    Section of Neurosurgery, VA Connecticut Healthcare System, West Haven, Connecticut, USA
    Health Qual Life Outcomes 7:1. 2009
    ....
  58. ncbi Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    Robert J Motzer
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    N Engl J Med 356:115-24. 2007
    ..Since sunitinib malate has shown activity in two uncontrolled studies in patients with metastatic renal-cell carcinoma, a comparison of the drug with interferon alfa in a phase 3 trial is warranted...
  59. ncbi Size and burden of mental disorders in Europe--a critical review and appraisal of 27 studies
    Hans Ulrich Wittchen
    Clinical Psychology and Psychotherapy, Technical University of Dresden, Dresden, Germany
    Eur Neuropsychopharmacol 15:357-76. 2005
    ..These needs are most pronounced for the new EU member states as well as more generally for adolescent and older populations...
  60. pmc The Patient-Reported Outcomes Measurement Information System (PROMIS) developed and tested its first wave of adult self-reported health outcome item banks: 2005-2008
    David Cella
    Medical Social Sciences, Northwestern University, 710 North Lakeshore Drive, Chicago, IL 60611, USA
    J Clin Epidemiol 63:1179-94. 2010
    ..We report results from the first large-scale testing of PROMIS items...
  61. ncbi Health promoting outdoor environments--associations between green space, and health, health-related quality of life and stress based on a Danish national representative survey
    Ulrika K Stigsdotter
    Forest and Landscape Denmark, University of Copenhagen, Denmark
    Scand J Public Health 38:411-7. 2010
    To investigate the associations between green space and health, health-related quality of life and stress, respectively.
  62. ncbi Methodological approaches for assessing response shift in longitudinal health-related quality-of-life research
    C E Schwartz
    Frontier Science and Technology Research Foundation Inc, Chestnut Hill, MA 02467, USA
    Soc Sci Med 48:1531-48. 1999
    The impact of health state changes on an individual's quality of life (QOL) has gained increased attention in social and medical clinical research...
  63. ncbi Valuing the ICECAP capability index for older people
    Joanna Coast
    University of Birmingham, Department of Health Economics, Public Health Building, Birmingham B15 2TT, UK
    Soc Sci Med 67:874-82. 2008
    ..The ICECAP index of capability for older people focuses on quality of life rather than health or other influences on quality of life, and is intended to be used in decision making ..
  64. ncbi Factors that influence disease-specific quality of life or health status in patients with COPD: a review and meta-analysis of Pearson correlations
    Ioanna Tsiligianni
    University Medical Center, University of Groningen, Groningen, The Netherlands
    Prim Care Respir J 20:257-68. 2011
    A major goal in the management of chronic obstructive pulmonary disease (COPD) is to ensure that the burden of the disease for patients with COPD is limited and that patients will have the best possible quality of life.
  65. ncbi The KIDSCREEN-52 quality of life measure for children and adolescents: psychometric results from a cross-cultural survey in 13 European countries
    Ulrike Ravens-Sieberer
    School of Public Health, WHO Collaborating Center for Child and Adolescent Health Promotion, University of Bielefeld, Germany
    Value Health 11:645-58. 2008
    This study assesses the reliability and validity of the European KIDSCREEN-52 generic health-related quality of life (HRQoL) questionnaire for children and adolescents.
  66. ncbi Prevalence and impact on quality of life of peripheral neuropathy with or without neuropathic pain in type 1 and type 2 diabetic patients attending hospital outpatients clinics
    K Van Acker
    Department of Endocrinology, St Jozef Clinic, Bornem, Belgium
    Diabetes Metab 35:206-13. 2009
    ..The association of DPN and DPN-P with other diabetic complications, the impact on quality of life (QoL) and pain management were also investigated.
  67. ncbi Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled study
    Upendram Srinivas-Shankar
    Andrology Research Unit, Department of Medicine and Endocrinology, University of Manchester, Manchester Royal Infirmary, Grafton Street, Manchester, United Kingdom M13 9WL
    J Clin Endocrinol Metab 95:639-50. 2010
    Physical frailty is associated with reduced muscle strength, impaired physical function, and quality of life. Testosterone (T) increases muscle mass and strength in hypogonadal patients...
  68. pmc Clinical, quality of life, and economic value of acromegaly disease control
    A Ben-Shlomo
    Pituitary Center, Department of Medicine, Cedars Sinai Medical Center, 110 George Burns Rd, Los Angeles, CA, 90048, USA
    Pituitary 14:284-94. 2011
    Although acromegaly is a rare disease, the clinical, economic and health-related quality of life (HRQoL) burden is considerable due to the broad spectrum of comorbidities as well as the need for lifelong management...
  69. pmc Psoriatic arthritis: epidemiology, clinical features, course, and outcome
    D D Gladman
    University of Toronto, Toronto Western Research Institute, Psoriatic Arthritis Program, Toronto Western Hospital, Toronto, Ontario M5T 2S8, Canada
    Ann Rheum Dis 64:ii14-7. 2005
    ..In addition to progression of clinical and radiological damage, health related quality of life is reduced among patients with PsA...
  70. ncbi Health-related quality of life in total hip and total knee arthroplasty. A qualitative and systematic review of the literature
    Olivier Ethgen
    WHO Collaborating Center for Public Health Aspects of Osteoarticular Diseases, Department of Public Health, Epidemiology, and Health Economics, University of Liege, Belgium, Liege, Belgium
    J Bone Joint Surg Am 86:963-74. 2004
    ..The objective of this study was to review the literature regarding the outcomes of total hip and knee arthroplasties as evaluated by health-related quality-of-life instruments...
  71. ncbi Collaborative care management of late-life depression in the primary care setting: a randomized controlled trial
    Jurgen Unutzer
    Center for Health Services Research, UCLA Neuropsychiatric Institute, 10920 Wilshire Blvd, Suite 300, Los Angeles, CA 90024, USA
    JAMA 288:2836-45. 2002
    ..Few depressed older adults receive effective treatment in primary care settings...
  72. ncbi Normalization of hemoglobin level in patients with chronic kidney disease and anemia
    Tilman B Drueke
    Inserm Unité 507 and Assistance Publique Hôpitaux de Paris, Necker Hospital, Division of Nephrology, Paris, France
    N Engl J Med 355:2071-84. 2006
    ..Whether correction of anemia in patients with stage 3 or 4 chronic kidney disease improves cardiovascular outcomes is not established...
  73. ncbi Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected]
    Masahiro Fukuoka
    Fourth Department of Internal Medicine, Kinki University School of Medicine, 377 2 Ohnohigashi Osakasayama, Osaka 589, Japan
    J Clin Oncol 21:2237-46. 2003
    ....
  74. ncbi The RAND-36 measure of health-related quality of life
    R D Hays
    UCLA Department of Medicine, UCLA School of Medicine, 90095 1736, USA
    Ann Med 33:350-7. 2001
    The RAND-36 is perhaps the most widely used health-related quality of life (HRQoL) survey instrument in the world today...
  75. ncbi The Health Education Impact Questionnaire (heiQ): an outcomes and evaluation measure for patient education and self-management interventions for people with chronic conditions
    Richard H Osborne
    Centre for Rheumatic Diseases, Department of Medicine, The University of Melbourne, Royal Melbourne Hospital, Parkville, Melbourne, Victoria 3050, Australia
    Patient Educ Couns 66:192-201. 2007
    ..The aim was to develop a user-friendly, relevant, and psychometrically sound instrument for the comprehensive evaluation of patient education programs, which can be applied across a broad range of chronic conditions...
  76. ncbi Humanistic and economic impacts of hepatitis C infection in the United States
    Marco daCosta Dibonaventura
    Health Sciences Practice, Kantar Health, New York, NY 10010, USA
    J Med Econ 13:709-18. 2010
    Prior research examining the effect of hepatitis C virus (HCV) on health-related quality of life (HRQoL) and healthcare costs is flawed because non-patient controls were not adequately comparable to HCV patients...
  77. ncbi The 15D instrument of health-related quality of life: properties and applications
    H Sintonen
    Department of Public Health, University of Helsinki, Finland
    Ann Med 33:328-36. 2001
    The 15D is a generic, comprehensive, 15-dimensional, standardized, self-administered measure of health-related quality of life (HRQoL) that can be used both as a profile and single index score measure...
  78. ncbi The Assessment of Quality of Life (AQoL) instrument: a psychometric measure of health-related quality of life
    G Hawthorne
    Department of Public Health and Community Medicine, University of Melbourne, Australia
    Qual Life Res 8:209-24. 1999
    This paper describes constructing the Assessment of Quality of Life (AQoL) instrument; designed to measure health-related quality of life (HRQoL), and to be the descriptive system for a multi-attribute utility instrument...
  79. pmc Changes in neuronal activation patterns in response to androgen deprivation therapy: a pilot study
    Monique M Cherrier
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA
    BMC Cancer 10:1. 2010
    ..However, men undergoing ADT may experience physical side effects, changes in quality of life and sometimes psychiatric and cognitive side effects.
  80. ncbi Health-related quality of life associated with chronic conditions in eight countries: results from the International Quality of Life Assessment (IQOLA) Project
    Jordi Alonso
    Health Services Research Unit, Institut Municipal d Investigacio Medica IMIM IMAS, Barcelona, Spain
    Qual Life Res 13:283-98. 2004
    Few studies and no international comparisons have examined the impact of multiple chronic conditions on populations using a comprehensive health-related quality of life (HRQL) questionnaire.
  81. ncbi Parent-child agreement across child health-related quality of life instruments: a review of the literature
    Penney Upton
    Department of Psychology and Health Sciences, University of Worcester, Worcester WR2 6AJ, UK
    Qual Life Res 17:895-913. 2008
    To systematically review the literature published since 1999 on paediatric health-related quality of life (HRQL) in relation to parent-child agreement.
  82. ncbi A pilot study of yoga for breast cancer survivors: physical and psychological benefits
    S Nicole Culos-Reed
    Faculty of Kinesiology, University of Calgary, Calgary, Canada
    Psychooncology 15:891-7. 2006
    ..g. fatigue, nausea), and improving overall well-being and quality of life. The purpose of the present pilot study was to examine the physical and psychological benefits afforded by a ..
  83. ncbi Association of Malnutrition-Inflammation Score with quality of life and mortality in hemodialysis patients: a 5-year prospective cohort study
    Mehdi Rambod
    Harold Simmons Center for Kidney Disease Research and Epidemiology, CA, USA
    Am J Kidney Dis 53:298-309. 2009
    ..We hypothesized that MIS risk stratification of hemodialysis (HD) patients in predicting outcomes is better than its components or laboratory markers of inflammation...
  84. ncbi Effectiveness of behavioral techniques and physical exercise on psychosocial functioning and health-related quality of life in breast cancer patients and survivors--a meta-analysis
    Saskia F A Duijts
    Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Psychooncology 20:115-26. 2011
    To evaluate the effect of behavioral techniques and physical exercise on psychosocial functioning and health-related quality of life (HRQoL) outcomes in breast cancer patients and survivors.
  85. ncbi Effects of the calcimimetic cinacalcet HCl on cardiovascular disease, fracture, and health-related quality of life in secondary hyperparathyroidism
    John Cunningham
    University College London, The Middlesex Hospital, London, UK
    Kidney Int 68:1793-800. 2005
    ..Cinacalcet, a calcimimetic that modulates the calcium-sensing receptor, reduces parathyroid hormone (PTH) secretion and lowers serum calcium and phosphorus concentrations in patients with end-stage renal disease (ESRD) and secondary HPT...
  86. ncbi A longitudinal study on quality of life and depression in ALS patient-caregiver couples
    A Gauthier
    Dipartimento di Neuroscienze, University of Torino, Torino, Italy
    Neurology 68:923-6. 2007
    To evaluate the modification of quality of life (QoL) and depression in a series of amyotrophic lateral sclerosis (ALS) patient-caregiver couples during a period of 9 months and compare them to patients' ALS Functional Rating Scale (ALS-..
  87. ncbi Assessing quality of life in older adults with cognitive impairment
    Rebecca G Logsdon
    Department of Psychosocial and Community Health, University of Washington School of Nursing, Seattle, Washington 98195 8733, USA
    Psychosom Med 64:510-9. 2002
    This article discusses theoretical, psychometric, and practical considerations of quality of life assessment in older adults with cognitive impairment...
  88. ncbi Musculoskeletal pain in the workforce: the effects of back, arthritis, and fibromyalgia pain on quality of life and work productivity
    Margaret McDonald
    Pfizer Inc, New York, NY, USA
    J Occup Environ Med 53:765-70. 2011
    To investigate the impact of musculoskeletal pain on health-related quality of life and work productivity losses among US workers.
  89. ncbi Evidence-based guidelines for determination of sample size and interpretation of the European Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30
    Kim Cocks
    Clinical Trials Research Unit, University of Leeds, United Kingdom, LS2 9JT
    J Clin Oncol 29:89-96. 2011
    PURPOSE; To use published literature to estimate large, medium, and small differences in quality of life (QOL) data from the European Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-..
  90. pmc Comparison of health-related quality of life measures in chronic obstructive pulmonary disease
    A Simon Pickard
    Center for Pharmacoeconomic Research and Department of Pharmacy Practice, University of Illinois at Chicago, IL 60612, USA
    Health Qual Life Outcomes 9:26. 2011
    ..e., EQ-5D and SF-36); and (2), to evaluate the strength of associations among clinical and health-related quality of life (HRQL) measures in chronic obstructive pulmonary disease (COPD).
  91. pmc Impact of medical Qigong on quality of life, fatigue, mood and inflammation in cancer patients: a randomized controlled trial
    B Oh
    Department of Medicine, Concord Repatriation General Hospital, University of Sydney, Concord, New South Wales, Australia
    Ann Oncol 21:608-14. 2010
    ..This study aimed to evaluate in a randomized controlled trial, the use of Medical Qigong (MQ) compared with usual care to improve the quality of life (QOL) of cancer patients.
  92. ncbi Nonpharmacological therapies in Alzheimer's disease: a systematic review of efficacy
    Javier Olazarán
    Maria Wolff Foundation, Madrid, Spain
    Dement Geriatr Cogn Disord 30:161-78. 2010
    Nonpharmacological therapies (NPTs) can improve the quality of life (QoL) of people with Alzheimer's disease (AD) and their carers...
  93. ncbi Randomized controlled trial of yoga among a multiethnic sample of breast cancer patients: effects on quality of life
    Alyson B Moadel
    Albert Einstein College of Medicine, Department of Epidemiology and Population Health, Bronx, NY 10461, USA
    J Clin Oncol 25:4387-95. 2007
    This study examines the impact of yoga, including physical poses, breathing, and meditation exercises, on quality of life (QOL), fatigue, distressed mood, and spiritual well-being among a multiethnic sample of breast cancer patients.
  94. ncbi Subthalamic nucleus deep brain stimulation: summary and meta-analysis of outcomes
    Galit Kleiner-Fisman
    Parkinson s Disease Research Education and Clinical Center, Philadelphia VA Hospital, Philadelphia, Pennsylvania 19104, USA
    Mov Disord 21:S290-304. 2006
    ..Patient demographics, reduction in medication requirements, change in dyskinesia, daily offs, quality of life, and a ratio of postoperative improvement from stimulation compared to preoperative improvement by medication ..
  95. ncbi Determining clinically important differences in health status measures: a general approach with illustration to the Health Utilities Index Mark II
    G Samsa
    Center for Clinical Health Policy Research, Duke University School of Medicine, Durham, North Carolina, USA
    Pharmacoeconomics 15:141-55. 1999
    ..This makes interpretation of HR-QOL results from clinical trials difficult, and having a benchmarking process which is relatively straightforward would be highly desirable...
  96. ncbi The use of patient reported outcome measures in routine clinical practice: lack of impact or lack of theory?
    Joanne Greenhalgh
    Health Care Practice R and D Unit, Allerton Building, University of Salford, Salford M6 6PU, UK
    Soc Sci Med 60:833-43. 2005
    ..why the use of patient-reported outcome (PRO) measures in clinical practice, in particular, health-related quality of life (HRQoL) instruments, has little or no apparent influence on clinical decision making...
  97. ncbi Transitional care of older adults hospitalized with heart failure: a randomized, controlled trial
    Mary D Naylor
    Gerontological Nursing Science Center, School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Am Geriatr Soc 52:675-84. 2004
    ..To examine the effectiveness of a transitional care intervention delivered by advanced practice nurses (APNs) to elders hospitalized with heart failure...
  98. ncbi Health-related quality of life of medical students
    Helena B M S Paro
    Department of Health Sciences, Federal University of Uberlandia, Uberlandia, Minas Gerais, Brazil
    Med Educ 44:227-35. 2010
    ..It has been speculated that these problems impair students' quality of life (QoL)...
  99. ncbi Persisting consequences of stroke measured by the Stroke Impact Scale
    Sue Min Lai
    Department of Preventive Medicine, University of Kansas Medical Center, Kansas City, KS 66160 7313, USA
    Stroke 33:1840-4. 2002
    The purpose of this study was to compare disability and quality of life as measured by the Stroke Impact Scale (SIS) of stroke patients deemed recovered (Barthel Index > or =95) with 2 stroke-free populations of community-dwelling ..
  100. pmc Health-related quality of life in 640 head and neck cancer survivors after radiotherapy using EORTC QLQ-C30 and QLQ-H&N35 questionnaires
    Stephen Wan Leung
    Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    BMC Cancer 11:128. 2011
    ..RT), many patients with head and neck cancer (HNC) can be effectively cured, and their health-related quality of life (HR-QoL) has become an important issue...
  101. pmc The Functional Assessment of Chronic Illness Therapy (FACIT) Measurement System: properties, applications, and interpretation
    Kimberly Webster
    Center on Outcomes, Research and Education, Evanston Northwestern Healthcare and Northwestern University Feinberg School of Medicine, Evanston, Illinois, United States
    Health Qual Life Outcomes 1:79. 2003
    ..Functional Assessment of Chronic Illness Therapy (FACIT) Measurement System is a collection of health-related quality of life (HRQOL) questionnaires targeted to the management of chronic illness...

Research Grants78

  1. Treatment decision making in older adults newly diagnosed with multiple myeloma
    Joseph D Tariman; Fiscal Year: 2010
    ..Nursing Strategic Plan calling for research studies on self management strategies that could lead to improved quality of life. Specifically, this study will be seminal for developing an intervention to promote active health care ..
  2. A+ Asthma Rural Partnership
    Arlene Butz; Fiscal Year: 2004
    ..4 percent of children aged 5-14 years in the United States. It has a significant impact on the quality of life of these children...
  3. PROSTATE CANCER--FAMILY CARE FOR PATIENTS AND SPOUSES
    Laurel Northouse; Fiscal Year: 2005
    ..such as sexual impotence, urinary incontinence, and bowel dysfunction that can severely affect the quality of life of men and their spouses...
  4. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..in the work statement, for specified clinical research data bases, cost-effectiveness and economic analyses, quality of life assessment and outcomes research...
  5. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..in the work statement, for specified clinical research data bases, cost-effectiveness and economic analyses, quality of life assessment and outcomes research...
  6. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  7. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  8. Bone Deficits and Excess Adiposity after Pediatric Bone Marrow Transplantation
    Sogol Mostoufi-Moab; Fiscal Year: 2013
    ..significant risks for skeletal fragility and the metabolic syndrome, with substantil impact on health-related quality of life. Longitudinal studies are imperative to determine the onset and progression of these abnormalities, and to ..
  9. Cardiovascular Responses to Sleep Apnea in Tetraplegia: A Pilot Study
    Jill M Wecht; Fiscal Year: 2010
    ..conditions that beset veterans with SCI and how best to treat them, with the ultimate goal of improving quality of life for these individuals is highly relevant to the VA Patient Care Mission...
  10. The gastric X/A-like (ghrelin) cell: A peripheral regulator of food intake
    NILS WG LAMBRECHT; Fiscal Year: 2012
    ..A complete understanding of this mechanism will improve the quality of life in our veteran patients by preventing serious medical complications...
  11. Pituitary dysfunction, behavioral symptoms, and quality of life after blast mTBI
    CHARLES WILLIAM WILKINSON; Fiscal Year: 2012
    ..postconcussive syndrome, including fatigue, anxiety, depression, irritability, insomnia, and decreased quality of life (QoL), as well as changes in body composition including increased fat percentage, hyperlipidemia, and a ..
  12. Behavioral Activation Therapy for Rural Veterans with Diabetes and Depression
    Aanand Dinkar Naik; Fiscal Year: 2013
    ..co-occurrence of diabetes and depressive symptoms is highly prevalent and has dramatic consequences on the quality of life and health of affected patients...
  13. The role of Fli1 in T cell function and the pathogenesis of lupus
    Tamara K Nowling; Fiscal Year: 2011
    ..this disease;thus relieving the burden of increased health care costs for these patients and improving their quality of life. PUBLIC HEALTH RELEVANCE: The Ets factor Fli1 has been implicated as a key modulator of lupus disease ..
  14. Mechanisms of action of ghrelin in muscle and adipose tissue in cancer-related ca
    Jose M Garcia; Fiscal Year: 2013
    ..Cachexia also contributes to a decrease in functional performance, quality of life and survival. However, treatments for this condition are lacking...
  15. Mechanism of Bladder Overactivity in Pelvic Ischemia
    Kazem M Azadzoi; Fiscal Year: 2013
    ..It has been reported that Veterans with overactive bladder have a worse quality of life score in comparison with Veterans without overactive bladder...
  16. Preclinical Development of JS-K, a Novel NO-Generating Prodrug for Cancer
    Paul J Shami; Fiscal Year: 2012
    ..of this novel cancer fighting drug, JS-K, will establish a new paradigm in cancer therapy, improve the quality of life for cancer patients and their families with less painful, more effective treatments, and provide a ..
  17. Controlling Radiation Injury by TLR5 Agonists
    Andrei V Gudkov; Fiscal Year: 2012
    ..In contrast, GI radiation syndrome remains poorly treatable resulting in significant mortality and reduced quality of life for survivors...
  18. Prolonged Inhibition of Pathologic Neovascularization by Catalytic Antioxidants
    JAMES FRANCIS MCGINNIS; Fiscal Year: 2013
    ..treatment to protect the health and function of retinal cells and thereby prolong vision and improve the quality of life for patients with DR or AMD...
  19. Analyzer for Monitoring Personal Environmental Exposure to Fluids and Materials
    MATTHEW CUSACK; Fiscal Year: 2010
    ..analyzer will facilitate much needed links between genetics and exposure research leading to improvements in quality of life while reducing healthcare costs related to a variety of chronic conditions...
  20. Recombinant Attenuated Salmonella Vaccines for Humans
    Roy Curtiss; Fiscal Year: 2012
    ..and economic well being (the latter dependent on the first two) provides the best means to enhance the quality of life globally and thus reduces conditions that result in warlike and terrorist behavior, we propose a vaccine ..
  21. Adenosine and the Basal Forebrain in the Control of Behavioral State
    Robert E Strecker; Fiscal Year: 2012
    ..leading to impaired occupational performance and safety, as well as impacting on general health and quality of life. The ability to perform at a high level under the condition of limited sleep is also very important to active ..
  22. Efficacy of Yoga for Treatment-Resistant PTSD
    Bessel Van der Kolk; Fiscal Year: 2010
    ..between trauma exposure and 1) PTSD, anxiety &depression, 2) loss of affect regulation, 3) poor quality of life, and 4) high health care utilization (2, 3)...
  23. Intracellular Phase Diagram Creation Using a Micro-Differential Scanning Calorime
    GARY L SOLBREKKEN; Fiscal Year: 2010
    ..An aging population is demanding such procedures for improving their quality of life. Therefore the need for effective biological material storage has become increasingly important...
  24. INTERNET ENHANCED HEALTH PROMOTION FOR OBESE ETHNIC MINORITY ADOLESCENTS
    Jessica A Whiteley; Fiscal Year: 2011
    ..resistance, type 2 diabetes, hypertension, obstructive sleep apnea, poor self-esteem, lower health-related quality of life (Rashid &Roberts, 2000;Rosenbloom, 2002;Sorof, Lai, Turner, Poffenbarger, &Portman, 2004;Wing et al...
  25. MR Monitoring of PTC124 Treatment in DMD
    KRISTA H VANDENBORNE; Fiscal Year: 2010
    ..been lacking, and outcome measures for clinical trials have been limited to measures of muscle function and quality of life, serum biomarkers of muscle breakdown and invasive muscle biopsies...
  26. Salmonella Vaccines Against Bacterial Enteropathogens
    Roy Curtiss; Fiscal Year: 2013
    ..and economic well-being (the latter dependent on the first two) provide the best means to enhance the quality of life globally...
  27. Therapeutic Effect of a Novel Antioxidant on Degenerative Eye Disorders
    Nuran Ercal; Fiscal Year: 2012
    ..Diseases such as cataracts and age-related macular degeneration significantly affect quality of life and represent sizable medical costs. The annual total outlay for cataract surgery each year in the U.S...
  28. Disease chronicity in juvenile dermatomyositis (JDM): Epigenetic clues
    Lauren M Pachman; Fiscal Year: 2013
    ..The children have a decreased quality of life, but the role of chronic inflammation has not been evaluated...
  29. Novel Means to Establish Free Radical Balance in the Neonatal Premature Lung
    Prakash Jagtap; Fiscal Year: 2011
    ..requirement for supplemental O2, to the extent of a crippling respiratory impairment with profound effects on quality of life and necessitating frequent and lifelong hospitalizations for pneumonia and bronchiolitis...
  30. Radiation-Induced Osteoporosis in Women with Cancer: Mechanisms and Prevention
    Ted A Bateman; Fiscal Year: 2013
    ..do survive, 85% will not be walking unaided at one year, and most survivors will never return to pre-fracture quality of life. In our preclinical models, ionizing radiation rapidly activated osteoclastic bone resorption and caused a ..
  31. Anti-Bacterial Innate Responses Enhance Paramyxovirus Replication
    Griffith D Parks; Fiscal Year: 2010
    ..Sequelae of recurrent otitis media include hearing and speech impairment that significantly impact the quality of life of both children and their parents/caregivers...
  32. Role of TPH2 and 5HT Neuronal Loss in Non-motor Symptoms of Parkinson's
    Donald M Kuhn; Fiscal Year: 2012
    ..to the disease process or L-DOPA-induced, are not trivial and contribute to worsened disability, impaired quality of life and shortened life expectancy...
  33. Effectiveness and Safety of Antithrombotic Strategies after Joint Replacement
    Elaine Hylek; Fiscal Year: 2013
    ..include post thrombotic syndrome and pulmonary hypertension which are each associated with low health-related quality of life (HRQOL), reduced survival, and high costs...
  34. Effectivenss of a New Non-Invasive Erectile Support System in Aging Populations
    S ALEXANDER WEINSTOCK; Fiscal Year: 2012
    ....
  35. Role of beta-endorphin in cancer therapy induced fatigue
    David E Fisher; Fiscal Year: 2013
    ..of opiate pathway modulation using existing drugs, as a targeted therapeutic approach for this major quality of life challenge in cancer patients...
  36. Study of zidovudine addition in HIV-associated neurocognitive disorders
    Albert Anderson; Fiscal Year: 2013
    ..The presence of HAND is a risk factor for work disability, poor quality of life, and mortality...
  37. Osteoclastic Protein-Tyrosine Phosphatase and Resorption
    Kin Hing William Lau; Fiscal Year: 2013
    ..overcome and/or even prevent osteoporosis would significantly reduce the morbidity with aging and improve the quality of life. A reduction in hip fractures, which can be a particular debilitating symptom of osteoporosis, would be ..
  38. Improving Patient Safety: Context and Nurses'Work Processes for Pressure Ulcers
    Lynn M Soban; Fiscal Year: 2013
    ..Inpatient pressure ulcers are usually preventable and developing strategies to decrease ulcers could increase quality of life and result in substantial cost savings...
  39. Anti-Fibrotic Therapy for Scleroderma/SSc
    Latha Paka; Fiscal Year: 2010
    ..Treatment is currently limited to management of symptoms in order to improve quality of life and limit long-term complications...
  40. Secondary Muscle Pathology &Metabolic Dysregulation in Adult with Cerebral Palsy
    Mark Peterson; Fiscal Year: 2013
    ..of the specific clinical aspects of CP, including issues pertaining to severity of motor impairment and quality of life, the negative influence of treatments on health and activity, and how impairment effects social participation ..
  41. Tadalafil for Pulmonary Hypertension Associated with Chronic Lung Disease
    SHARON IRENE SMITH ROUNDS; Fiscal Year: 2013
    ..of pulmonary artery systolic pressure and right ventricular function, dyspnea severity, health related quality of life assessed by validated standardized questionnaires, and, the frequency of COPD exacerbations at 12 months...
  42. Salivary-based Bone-loss Marker Detection Platform for Point-of-Care Screening
    MANAL BESHAY; Fiscal Year: 2012
    ..earlier detection of bone loss, which in turn will result in more effective treatment options, improving the quality of life of osteoporotic patients...
  43. Nutrition and Anabolic Interventions in Cancer Cachexia
    Melinda Sheffield-Moore; Fiscal Year: 2013
    ..cachexia severely depletes skeletal muscle mass leading to impairments in physical function and a diminished quality of life. In the clinical realm, malnutrition and cachexia are synonymous...
  44. Mindfulness Based Stress Reduction as an Adjunctive Treatment for Psoriasis
    Jan A Moynihan; Fiscal Year: 2013
    ..Psoriasis patients commonly report significant reductions in quality of life, as well as social stigmatization, increased rates of anxiety and depression, and increased thoughts of ..
  45. Amelioration of cisplatin ototoxicity by transplatin
    Debashree Mukherjea; Fiscal Year: 2010
    ..Such a treatment could improve the quality of life of cancer patients who would otherwise face many years of poor communication because of hearing loss caused ..
  46. Fall risk assessment and prevention in elderly with diabetes using wearable techn
    Bor Rong Chen; Fiscal Year: 2012
    ..exhibit concomitant postural instability that can lead to falls, fracture, depression, anxiety, and decreased quality of life. Individuals with diabetes are 2...
  47. Liver disease in CF: CFTR controls innate immunity in biliary epithelium
    Mario Strazzabosco; Fiscal Year: 2013
    ..Cystic Fibrosis liver disease (CFLD) negatively impacts the quality of life and survival of CF patients, and may require liver transplantation, however, the pathogenesis of this ..
  48. Comparative Effectiveness of Medical Therapy vs. Bariatric Surgery for Obese T2DM
    DAVID BRADLEY contact LAUTZ; Fiscal Year: 2010
    ..Longitudinal measures of patient reported quality of life outcomes, and cost utility measures, will be collected to generate preliminary data for the design of a more ..
  49. B Cell Development in Aging
    John C Cambier; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: A proportion of aged individuals suffer poor quality of life due to acquired immune defects that reduce their ability to fight infection...
  50. Effects of spinal cord injury on vagal afferents from the rat bladder and colon.
    April N Herrity; Fiscal Year: 2013
    ..Furthermore, deficits in urological functin rank high as one of the most important factors affecting quality of life for SCI patients 6...
  51. PKC delta and cell renewal in irradiated taste epithelium
    MARY ELAINE REYLAND; Fiscal Year: 2012
    ..tend to lack appetite and eat far less, leading to weight loss, as well as a significantly compromised quality of life. While radiotherapy induced taste loss is a well-documented side effect of cancer treatment, the precise ..
  52. Addressing Psychosocial Disparities in Rural Hispanic Cancer Survivors
    Rachel M Ceballos; Fiscal Year: 2013
    ..a rural community, (2) evaluate the effect of the Spanish-language support resource on validated measures of quality of life and psychosocial well-being and, (3) evaluate the effect of the support resource on measures of serum c-..
  53. Improving Hmong Health through Community Based Participatory Research
    DIAN LORENE BAKER; Fiscal Year: 2013
    ..navigators for Hmong community members with T2DM, (3) translate and evaluate the World Health Organization Quality of Life-BREF instrument for care management and biomedical research of T2DM among the Hmong community, (4) conduct a ..
  54. Hiv-1 Infection: Central Serotonergic Activity and its Health Implications
    Adarsh M Kumar; Fiscal Year: 2010
    ..the most common neuropsychiatric disorders in a large number of HIV-1 infected individuals, and affects their quality of life, interferes in adherence to treatment, and is a risk factor for disease progression, and mortality...
  55. Calorie Restriction &Body Composition, Function, &QoL in Older Adults
    Julie L Locher; Fiscal Year: 2013
    ..The risks of cardiometabolic diseases (e.g., diabetes, heart disease) and declines in functional status and quality of life for older adults will be extraordinarily high...
  56. Controlled delivery of polypeptide hormone calcitonin
    Jagdish Singh; Fiscal Year: 2013
    ..Development of such a novel therapeutic system is critical for successful treatment of bone diseases, especially osteoporosis in men and postmenopausal women, in order to improve patient quality of life.
  57. Modulation of Natriuretic Peptides via Caveolin in Hypertrophy and Heart Failure.
    David M Roth; Fiscal Year: 2013
    ..Heart failure is associated with high mortality and morbidity and poor quality of life. Heart failure affects nearly 5 million Americans and is listed on 1 out of every 8 death-certificates in the ..
  58. Mechanisms and Enviromental Determinants of Rhinovirus Illness Severity
    James E Gern; Fiscal Year: 2013
    ..As such, VRIs are a significant public health problem impacting the quality of life of affected children and places increased societal strain in the workplace and on health care utilization...
  59. Iyengar yoga for adolescents and young adults with irritable bowel syndrome
    Subhadra Evans; Fiscal Year: 2013
    ..with diarrhea and/or constipation and other gastroenterological symptoms, which can significantly impact quality of life and daily functioning of patients...
  60. Pharmacological strategies to improve breathing after cervical spinal cord injury
    FRANCIS GOLDER; Fiscal Year: 2009
    ..therapeutic approaches that restore respiratory function can significantly improve a person[unreadable]s quality of life. Our proposal is highly significant because: 1) we propose investigating a therapeutic strategy that may be ..
  61. Validation of a Novel NF-kB Inhibitor in Inflammatory Bowel Disease
    Anthony Blikslager; Fiscal Year: 2013
    ..This would be an important advancement to minimize toxicity, increase patient compliance, and improve quality of life. To address these challenges, we have developed microemulsion (ME)- based delivery systems suitable for local ..
  62. CHEMOSENSORY PERCEPTION AND PSYCHOPHYSICS IN THE AGED
    CLAIRE L MURPHY; Fiscal Year: 2013
    Description (provided by applicant): Optimum health, functioning and nutritional status are key to the quality of life in the older American...
  63. Novel treatment of menopausal hot flushes with an estradiol prodrug
    Laszlo Prokai; Fiscal Year: 2012
    ..Hot flushes often negatively impact the quality of life of women because they are associated with sleep disturbances resulting in fatigue, depression, irritability, ..
  64. Reversing Corticosteroid-Induced Memory Impairment
    E Sherwood Brown; Fiscal Year: 2013
    ..The impact of lamotrigine on memory, mood, quality of life, structural imaging, and spectroscopy will be examined.
  65. Effect of Ultrafiltration on Clinical Outcomes and Health-related Quality of Life
    KELLY VICTORIA LIANG; Fiscal Year: 2013
    ..investigator with expertise in cardiorenal failure, volume management, and assessment of health-related quality of life (HRQOL)...
  66. SURGICAL TREATMENTS OUTCOMES PROJECT FOR DUB (STOP-DUB)
    Kay Dickersin; Fiscal Year: 2000
    ..Secondary measures of outcome include quality of life (QOL) issues...
  67. Older Mothers and Adult Daughters: High Blood Pressure Self Management Behaviors
    Celeste Shawler; Fiscal Year: 2010
    ..nursing interventions can be developed to improve cardiovascular self management behaviors and health related quality of life. The specific aim of this longitudinal predictive study is to determine the impact of inner strength, ..
  68. Treating Insomnia & Nightmares After Trauma: Impact on Symptoms & Quality of Life
    Sean P A Drummond; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Treating Insomnia &Nightmares After Trauma: Impact on Symptoms &Quality of Life This application addresses broad Challenge Area (04) Clinical Research and specific Challenge Topic, 04-NR- 103*..
  69. PRIDE: Program to Reduce Incontinence by Diet & Exercise
    Deborah Grady; Fiscal Year: 2007
    Urinary incontinence Is a commonproblem among women that causesdistress, diminished quality of life and dramatic limitations in daily functioning...
  70. Aspiration Pneumonia in Children with Neurological Impairment
    Rajendu Srivastava; Fiscal Year: 2009
    ..commonly experience AP from gastroesophageal reflux disease (GERD), placing them at high risk for compromised quality of life, repeated hospitalization, respiratory failure, and death...
  71. MEASURING QOL DURING TREATMENT FOR SLEEP APNEA
    JEANNETTE BREUGELMANS; Fiscal Year: 2000
    ..the relative importance of acquiring health status information on a sleep apnea patient's functioning and quality of life by partners as proxy raters...
  72. RCT of Two Speed of Processing Modes to Prevent Cognitive Decline in Older Adults
    FREDRIC DAVID WOLINSKY; Fiscal Year: 2010
    ..for 05-AG-102 is the prevention of cognitive disability that results in health outcomes including improved quality of life, decreased mortality, morbidity, and disease progression, reduced medical care costs, and improvements in ..
  73. Testosterone Replacement Therapy in Advanced Chronic Kidney Disease
    Ralph Rabkin; Fiscal Year: 2009
    ..be effective in preventing and treating the loss of muscle mass and function in CKD patients, will improve quality of life and may reduce some cardiovascular disease (CVD) risk factors...
  74. RESILIENCE & QUALITY OF LIFE IN ADOLESCENTS WITH CANCER
    Joan Haase; Fiscal Year: 2000
    ..of this study are to: 1) examine, longitudinally, the nature and patterns of change in resilience and quality of life through analysis of the Adolescent Resilience Model (ARM) in adolescents with cancer; and, 2) evaluate the ..
  75. Biobehavioral Effects of Tai Chi Chih Among Elderly Breast Cancer Survivors
    Anita Y Kinney; Fiscal Year: 2010
    ..had cancer, both short-term and long-term elderly breast cancer survivors are more likely to report worse quality of life, high rates of psychological distress, poorer general health status, and more functional limitations...
  76. Urinary Incontinence in Breast Cancer Survivors: A Controlled Comparsion
    KRISTINE ANNE DONOVAN; Fiscal Year: 2010
    ..large body of research has documented the prevalence and severity of menopausal symptoms and their impact on quality of life in breast cancer survivors (BC+ survivors)...
  77. "Strength training, Self-efficacy, and Function in Blacks with Prostate Cancer."
    Bernard Hurley; Fiscal Year: 2009
    ..fatigue, bone loss, increased fat deposition, and functional declines that lead to a deterioration in quality of life. Strength training (ST) is now considered the intervention of choice to improve muscle size and strength and ..
  78. Weight Loss and Exercise in Frail Obese Elderly Subjects
    DENNIS VILLAREAL; Fiscal Year: 2009
    Abstract: Obesity causes serious medical complications and impairs quality of life. Moreover, in elderly persons, obesity can lead to frailty by exacerbating the decline in strength, endurance, balance and mobility associated with aging ..