survival

Summary

Summary: Continuance of life or existence especially under adverse conditions; includes methods and philosophy of survival.

Top Publications

  1. ncbi Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine
    Marcela V Karpuj
    Department of Neurological Sciences, Stanford University, Stanford, California, USA
    Nat Med 8:143-9. 2002
  2. doi Clinical risk factors for malignancy and overall survival in patients with pheochromocytomas and sympathetic paragangliomas: primary tumor size and primary tumor location as prognostic indicators
    Montserrat Ayala-Ramirez
    Department of Endocrine Neoplasia and Hormonal Disorders, Unit 1461, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, Texas 77030, USA
    J Clin Endocrinol Metab 96:717-25. 2011
  3. pmc Parkin protein deficiency exacerbates cardiac injury and reduces survival following myocardial infarction
    Dieter A Kubli
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093 0758, USA
    J Biol Chem 288:915-26. 2013
  4. ncbi Maternal mortality and the consequences on infant and child survival in rural Haiti
    Frank W J Anderson
    Department of Obstetrics and Gynecology, University of Michigan Medical School, Ann Arbor, MI, USA
    Matern Child Health J 11:395-401. 2007
  5. doi Survival in extreme environments - on the current knowledge of adaptations in tardigrades
    N Møbjerg
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    Acta Physiol (Oxf) 202:409-20. 2011
  6. pmc Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation
    Chanhee Kang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Genes Dev 21:2161-71. 2007
  7. doi Assessing the impact of climate variation on survival in vertebrate populations
    V Grosbois
    Centre d Ecologie Fonctionnelle et Evolutive, UMR 5175, 1919 Route de Mende, F 34293 Montpellier cedex 5, France
    Biol Rev Camb Philos Soc 83:357-99. 2008
  8. ncbi Background and gender effects on survival in the TgN(SOD1-G93A)1Gur mouse model of ALS
    T D Heiman-Patterson
    Department of Neurology, Drexel University College of Medicine, Mail Stop 423, 245 North 15th Street, Philadelphia, PA 19102, USA
    J Neurol Sci 236:1-7. 2005
  9. ncbi Oleuropein: a novel immunomodulator conferring prolonged survival in experimental sepsis by Pseudomonas aeruginosa
    Evangelos J Giamarellos-Bourboulis
    Fourth Department of Internal Medicine, Medical School, University of Athens, Greece
    Shock 26:410-6. 2006
  10. pmc The novel ETA receptor antagonist HJP-272 prevents cerebral microvascular hemorrhage in cerebral malaria and synergistically improves survival in combination with an artemisinin derivative
    Minxian Dai
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, United States
    Life Sci 91:687-92. 2012

Detail Information

Publications470 found, 100 shown here

  1. ncbi Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine
    Marcela V Karpuj
    Department of Neurological Sciences, Stanford University, Stanford, California, USA
    Nat Med 8:143-9. 2002
    ..When treatment began after the appearance of abnormal movements, cystamine extended survival, reduced associated tremor and abnormal movements and ameliorated weight loss...
  2. doi Clinical risk factors for malignancy and overall survival in patients with pheochromocytomas and sympathetic paragangliomas: primary tumor size and primary tumor location as prognostic indicators
    Montserrat Ayala-Ramirez
    Department of Endocrine Neoplasia and Hormonal Disorders, Unit 1461, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, Texas 77030, USA
    J Clin Endocrinol Metab 96:717-25. 2011
    ..Pheochromocytomas and sympathetic paragangliomas are rare neuroendocrine tumors for which no precise histological or molecular markers have been identified to differentiate benign from malignant tumors...
  3. pmc Parkin protein deficiency exacerbates cardiac injury and reduces survival following myocardial infarction
    Dieter A Kubli
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093 0758, USA
    J Biol Chem 288:915-26. 2013
    ..Parkin(-/-) mice had reduced survival and developed larger infarcts when compared with wild type mice after the infarction...
  4. ncbi Maternal mortality and the consequences on infant and child survival in rural Haiti
    Frank W J Anderson
    Department of Obstetrics and Gynecology, University of Michigan Medical School, Ann Arbor, MI, USA
    Matern Child Health J 11:395-401. 2007
    ..To determine the odds of death of children when a woman of reproductive age dies from maternal or non maternal causes in rural Haiti...
  5. doi Survival in extreme environments - on the current knowledge of adaptations in tardigrades
    N Møbjerg
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    Acta Physiol (Oxf) 202:409-20. 2011
    ..This review summarizes the current knowledge on adaptations found among tardigrades, and presents new data on tardigrade cell numbers and osmoregulation...
  6. pmc Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation
    Chanhee Kang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Genes Dev 21:2161-71. 2007
    ..Autophagy is thought to promote both cell and organism survival by providing fundamental building blocks to maintain energy homeostasis during starvation...
  7. doi Assessing the impact of climate variation on survival in vertebrate populations
    V Grosbois
    Centre d Ecologie Fonctionnelle et Evolutive, UMR 5175, 1919 Route de Mende, F 34293 Montpellier cedex 5, France
    Biol Rev Camb Philos Soc 83:357-99. 2008
    ..We review statistical procedures used in these analyses to study links between climatic factors and survival variation in vertebrate populations...
  8. ncbi Background and gender effects on survival in the TgN(SOD1-G93A)1Gur mouse model of ALS
    T D Heiman-Patterson
    Department of Neurology, Drexel University College of Medicine, Mail Stop 423, 245 North 15th Street, Philadelphia, PA 19102, USA
    J Neurol Sci 236:1-7. 2005
    ..We report the influence of background and gender on the survival of these congenic lines compared to the hybrid C57BL/6JxSJL/J background...
  9. ncbi Oleuropein: a novel immunomodulator conferring prolonged survival in experimental sepsis by Pseudomonas aeruginosa
    Evangelos J Giamarellos-Bourboulis
    Fourth Department of Internal Medicine, Medical School, University of Athens, Greece
    Shock 26:410-6. 2006
    ..b>Survival was recorded; bacterial growth in blood and organs was counted; endotoxins (LPS), malondialdehyde, total ..
  10. pmc The novel ETA receptor antagonist HJP-272 prevents cerebral microvascular hemorrhage in cerebral malaria and synergistically improves survival in combination with an artemisinin derivative
    Minxian Dai
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, United States
    Life Sci 91:687-92. 2012
    To investigate the association between vasculopathy and survival during experimental cerebral malaria (ECM), and to determine whether targeting the endothelin-1 (ET-1) pathway alone or in combination with the anti-malaria drug artemether (..
  11. ncbi Life-history evolution and the polyphenic regulation of somatic maintenance and survival
    Thomas Flatt
    Institut für Populationsgenetik, Vetmeduni Vienna, A 1210 Vienna, Austria
    Q Rev Biol 88:185-218. 2013
    ..from the perspective of adaptive phenotypic plasticity, with a focus on polyphenisms for somatic maintenance and survival. Polyphenisms are adaptive discrete alternative phenotypes that develop in response to changes in the environment...
  12. pmc Role of Leishmania (Leishmania) chagasi amastigote cysteine protease in intracellular parasite survival: studies by gene disruption and antisense mRNA inhibition
    Vasanthakrishna Mundodi
    Department of Biological Sciences, University of Calgary, Calgary AB T2N1N4, Canada
    BMC Mol Biol 6:3. 2005
    ..chagasi. Here, we have further characterized this cysteine protease gene and demonstrated its role during infection and survival of Leishmania (L.) chagasi within the U937 macrophage cells.
  13. ncbi A genetic mouse model to investigate hyperoxic acute lung injury survival
    Daniel R Prows
    Department of Pediatrics, University of Cincinnati College of Medicine, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Physiol Genomics 30:262-70. 2007
    ..Eighteen inbred mouse strains were screened in continuous >95% O2. A significant survival difference was identified between sensitive C57BL/6J and resistant 129X1/SvJ strains...
  14. pmc In situ measurement of coastal ocean movements and survival of juvenile Pacific salmon
    David W Welch
    Kintama Research Services, Nanaimo, BC, Canada
    Proc Natl Acad Sci U S A 108:8708-13. 2011
    ..and high ocean mortality in the past two decades, with some populations facing extirpation if current marine survival trends continue...
  15. pmc Adaptive sugar provisioning controls survival of C. elegans embryos in adverse environments
    Harold N Frazier
    Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98195, USA
    Curr Biol 19:859-63. 2009
    ..We show that this alteration of survival is correlated with changes in the sugar content of adults and embryos...
  16. ncbi Extended mitogenomic phylogenetic analyses yield new insight into crocodylian evolution and their survival of the Cretaceous-Tertiary boundary
    Jonas Roos
    Department of Cell and Organism Biology, Division of Evolutionary Molecular Systematics, University of Lund, Solvegatan 29, S 223 62 Lund, Sweden
    Mol Phylogenet Evol 45:663-73. 2007
    ..However, for whatever reason, some crocodylian lineages survived into the Tertiary...
  17. pmc Akt/FOXO3a/SIRT1-mediated cardioprotection by n-tyrosol against ischemic stress in rat in vivo model of myocardial infarction: switching gears toward survival and longevity
    Samson Mathews Samuel
    Molecular Cardiology and Angiogenesis Laboratory, Department of Surgery, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Agric Food Chem 56:9692-8. 2008
    ..these findings suggest that tyrosol induces myocardial protection against ischemia related stress by inducing survival and longevity proteins that may be considered as anti-aging therapy for the heart...
  18. doi Elevated neutrophil to lymphocyte ratio predicts survival in advanced pancreatic cancer
    Xin An
    State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, P R China
    Biomarkers 15:516-22. 2010
    Elevated neutrophil to lymphocyte ratio (NLR) is linked with worse survival in many malignancies, whereas its association with pancreatic cancer (PC) remains unclear.
  19. pmc Age, gender, and racial differences in incidence and survival in primary CNS lymphoma
    J L Villano
    Department of Medicine, Section of Hematology Oncology, University of Illinois at Chicago, Chicago, IL, USA
    Br J Cancer 105:1414-8. 2011
    ..The objective of this study was to analyse the epidemiology, incidence, and outcome of these rare tumours...
  20. ncbi Adaptive memory: survival processing enhances retention
    James S Nairne
    Department of Psychological Sciences, Purdue University, West Lafayette, IN 47907, USA
    J Exp Psychol Learn Mem Cogn 33:263-73. 2007
    ..might have evolved to help us remember fitness-relevant information--specifically, information relevant to survival. In 4 incidental learning experiments, people were asked to rate common nouns for their survival relevance (e.g...
  21. doi Adaptive memory: the comparative value of survival processing
    James S Nairne
    Department of Psychological Sciences, Purdue University, West Lafayette, IN 47907 2081, USA
    Psychol Sci 19:176-80. 2008
    We recently proposed that human memory systems are "tuned" to remember information that is processed for survival, perhaps as a result of fitness advantages accrued in the ancestral past...
  22. pmc synMuv B proteins antagonize germline fate in the intestine and ensure C. elegans survival
    Lisa N Petrella
    Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA
    Development 138:1069-79. 2011
    ..Somatic expression of germline genes is enhanced at elevated temperature, leading to developmentally compromised somatic cells and arrest of newly hatched larvae...
  23. ncbi Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis
    Mahmoud Kiaei
    Department of Neurology and Neuroscience, Weill Medical College, Cornell University, New York Presbyterian Hospital, New York, New York 10021, USA
    J Neurosci 26:2467-73. 2006
    ..Both compounds also reduced interleukin (IL)-12p40, IL-1alpha, and IL-1beta and increased IL-RA and TGF-beta1 mRNA. Therefore, both thalidomide and lenalidomide bear promise as therapeutic interventions for the treatment of ALS...
  24. ncbi Demographic analysis of a declining pika Ochotona collaris population: linking survival to broad-scale climate patterns via spring snowmelt patterns
    Shawn F Morrison
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2E9
    J Anim Ecol 76:899-907. 2007
    1. Demographic analysis is essential in order to determine which factors, such as survival, fertility and other life-history characteristics, have the greatest influence on a population's rate of growth (lambda). 2...
  25. doi Tumor expression of human growth hormone and human prolactin predict a worse survival outcome in patients with mammary or endometrial carcinoma
    Zheng Sheng Wu
    Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei, Anhui 230027, People s Republic of China
    J Clin Endocrinol Metab 96:E1619-29. 2011
    ..However, especially for hGH, the prognostic relevance of tumor expression of these hormones is not well defined...
  26. doi The value of progression-free survival to patients with advanced-stage cancer
    Lesley J Fallowfield
    Sussex Health Outcomes Research and Education in Cancer, Brighton and Sussex Medical School, University of Sussex, Falmer, East Sussex BN1 9RX, UK l j fallowfield sussex ac uk
    Nat Rev Clin Oncol 9:41-7. 2012
    Progression-free survival (PFS) is frequently used as a primary end point in oncology clinical trials...
  27. pmc Patient self-reports of symptoms and clinician ratings as predictors of overall cancer survival
    Chantal Quinten
    Quality of Life Department, European Organization for Research and Treatment of Cancer Headquarters, Brussels, Belgium
    J Natl Cancer Inst 103:1851-8. 2011
    ..We examined the extent to which patient and clinician symptom scoring and their agreement could contribute to the estimation of overall survival among cancer patients.
  28. doi Correlation between overall survival and growth modulation index in pre-treated sarcoma patients: a study from the French Sarcoma Group
    S Cousin
    Department of General Oncology, Oscar Lambret Center, Lille
    Ann Oncol 24:2681-5. 2013
    ..Nevertheless, its use has been limited until now...
  29. doi Socioeconomic deprivation and cancer survival in Germany: an ecological analysis in 200 districts in Germany
    Lina Jansen
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 134:2951-60. 2014
    Although socioeconomic inequalities in cancer survival have been demonstrated both within and between countries, evidence on the variation of the inequalities over time past diagnosis is sparse...
  30. ncbi Control of nerve agent-induced seizures is critical for neuroprotection and survival
    Tsung Ming Shih
    Pharmacology and Comparative Medicine Divisions, US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010 5400, USA
    Toxicol Appl Pharmacol 188:69-80. 2003
    ..All nerve agents were capable of producing neuropathology. Seizure control was strongly associated with protection against acute lethality and brain pathology...
  31. ncbi A maternal blood-borne factor promotes survival of the developing thalamus
    Peter Landgraf
    Institute of Physiology, Otto von Guericke University, Magdeburg, Germany
    FASEB J 19:225-7. 2005
    In this report, we describe the identification of a polypeptide survival-promoting factor that is produced by maternal and early postnatal peripheral blood mononuclear cells (PBMCs) of the immune system in Long-Evans rats and humans...
  32. doi Independent association of extent of resection with survival in patients with malignant brain astrocytoma
    Matthew J McGirt
    Department of Neurosurgery and Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Neurosurg 110:156-62. 2009
    ..in the adjuvant treatment of malignant brain astrocytomas, it is increasingly debated whether extent of resection affects survival. In this study, the authors investigate this issue after primary and revision resection of these lesions.
  33. pmc Survival from childhood cancer in northern England, 1968-2005
    N O Basta
    Institute of Health and Society, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, England, UK
    Br J Cancer 105:1402-8. 2011
    Cancer is the second most common cause of death in children in the developed world. The study investigated patterns and trends in survival from childhood cancer in patients from northern England diagnosed 1968-2005.
  34. pmc Graded loss of tuberin in an allelic series of brain models of TSC correlates with survival, and biochemical, histological and behavioral features
    Elizabeth Yuan
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Mol Genet 21:4286-300. 2012
    ..The mice demonstrate a progressive neurologic phenotype including hunchback, hind limb clasp, reduced survival and brain and cortical neuron enlargement that correlates with a graded reduction in expression of Tsc2 in the ..
  35. pmc Assessment of reproducibility of cancer survival risk predictions across medical centers
    Hung Chia Chen
    Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079, USA
    BMC Med Res Methodol 13:25. 2013
    Two most important considerations in evaluation of survival prediction models are 1) predictability - ability to predict survival risks accurately and 2) reproducibility - ability to generalize to predict samples generated from different ..
  36. ncbi Survival of patients with glioblastoma multiforme is not influenced by altered expression of p16, p53, EGFR, MDM2 or Bcl-2 genes
    E W Newcomb
    Department of Pathology, New York University Medical Center, New York 10016, USA
    Brain Pathol 8:655-67. 1998
    ..EGFR), MDM2 or Bcl-2 may contribute to the treatment resistance phenotype of GBM and generally poor patient survival. Clinically, GBM have been divided into two major groups defined by (1) histologic progression from a low grade ..
  37. ncbi Survival and neurologic outcomes in a randomized trial of motexafin gadolinium and whole-brain radiation therapy in brain metastases
    Minesh P Mehta
    University of Wisconsin Madison, Department Human Oncology Radiation Oncology, 53792, USA
    J Clin Oncol 21:2529-36. 2003
    This phase III randomized trial evaluated survival as well as neurologic and neurocognitive function in patients with brain metastases from solid tumors receiving whole-brain radiation therapy (WBRT) with or without motexafin gadolinium (..
  38. doi The association between autonomic dysfunction and survival in male patients with advanced cancer: a preliminary report
    Nada Fadul
    Department of Palliative Care and Rehabilitation Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Pain Symptom Manage 39:283-90. 2010
    ..It is associated with decreased survival in several patient populations, including diabetes mellitus, heart failure, and neurological diseases...
  39. doi Associations among hypogonadism, C-reactive protein, symptom burden, and survival in male cancer patients with cachexia: a preliminary report
    Egidio Del Fabbro
    Department of Palliative Care and Rehabilitation Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Pain Symptom Manage 39:1016-24. 2010
    ..without cancer, hypogonadism is associated with lower lean body mass, increased symptom burden, and decreased survival. Hypogonadism in cancer cachexia could exacerbate symptoms, facilitate a proinflammatory state, and decrease ..
  40. doi Adaptive memory: Survival processing increases both true and false memory in adults and children
    Henry Otgaar
    Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    J Exp Psychol Learn Mem Cogn 36:1010-6. 2010
    Research has shown that processing information in a survival context can enhance the information's memorability...
  41. doi Epidemiology and survival of systemic lupus erythematosus in Hong Kong Chinese
    C C Mok
    Department of Medicine, Tuen Mun Hospital, Hong Kong, China
    Lupus 20:767-71. 2011
    ..1% and 6.7/100,000 population, respectively. The 10-year cumulative survival of SLE patients in Hong Kong is 83% and the age and gender-adjusted standardized mortality ratio was 5.25 (1...
  42. pmc Direct regulation of membrane type 1 matrix metalloproteinase following myocardial infarction causes changes in survival, cardiac function, and remodeling
    Juozas A Zavadzkas
    Medical University of South Carolina and Ralph H Johnson Veteran s Affairs Medical Center, Charleston, South Carolina 29425, USA
    Am J Physiol Heart Circ Physiol 301:H1656-66. 2011
    ..However, the direct effects of altered MT1-MMP levels on survival, LV function, and geometry following myocardial infarction (MI) and the proteolytic substrates involved in this ..
  43. ncbi Lipoic acid improves survival in transgenic mouse models of Huntington's disease
    O A Andreassen
    Neurochemistry Laboratory, Neurology Service, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Neuroreport 12:3371-3. 2001
    ..S-PBN showed no effects on either weight loss or survival in the R6/2 transgenic HD mice...
  44. ncbi Methylation of O6-methylguanine DNA methyltransferase and loss of heterozygosity on 19q and/or 17p are overlapping features of secondary glioblastomas with prolonged survival
    Marica Eoli
    Unit of Clinical Neuro Oncology, Istituto Nazionale Neurologico Besta, Milan, Italy
    Clin Cancer Res 13:2606-13. 2007
    ..Results in contradiction with these findings, however, are present in the literature and the clinical and genetic context framing MGMT methylation is poorly characterized...
  45. doi On the susceptibility of adaptive memory to false memory illusions
    Mark L Howe
    Department of Psychology, Lancaster University, United Kingdom
    Cognition 115:252-67. 2010
    Previous research has shown that survival-related processing of word lists enhances retention for that material...
  46. doi Persistence with Chytridiomycosis does not assure survival of direct-developing frogs
    Ana V Longo
    Department of Ecology and Evolutionary Biology, Cornell University, E145 Corson Hall, Ithaca, NY 14853, USA
    Ecohealth 7:185-95. 2010
    ..Mark-recapture data was used to monitor Bd-infection status and estimate survival probabilities of infected versus uninfected adults...
  47. ncbi The survival benefit of measles immunization may not be explained entirely by the prevention of measles disease: a community study from rural Bangladesh
    Peter Aaby
    Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Seruminstitut, Copenhagen, Denmark
    Int J Epidemiol 32:106-16. 2003
    ..To examine whether the reduction in childhood mortality after immunization can be explained by the prevention of measles and its long-term effects...
  48. ncbi Establishment of a continuous model system to study Helicobacter pylori survival in potable water biofilms
    N F Azevedo
    Environmental Healthcare Unit, School of Biological Sciences, University of Southampton, Southampton, UK
    Water Sci Technol 47:155-60. 2003
    ..Using a two-stage water model, the survival and development of the pathogen in potable water biofilms was monitored...
  49. ncbi Mediastinal lymph node clearance after docetaxel-cisplatin neoadjuvant chemotherapy is prognostic of survival in patients with stage IIIA pN2 non-small-cell lung cancer: a multicenter phase II trial
    Daniel C Betticher
    Swiss Group for Clinical Cancer Research, Bern, Switzerland
    J Clin Oncol 21:1752-9. 2003
    ..A multicenter, phase II trial investigated the efficacy and toxicity of neoadjuvant docetaxel-cisplatin in locally advanced non-small-cell lung cancer (NSCLC) and examined prognostic factors for patients not benefiting from surgery...
  50. ncbi Obesity and survival after radical prostatectomy: A 10-year prospective cohort study
    Sameer A Siddiqui
    Department of Urology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer 107:521-9. 2006
    ..Obesity and prostate cancer are among the most common health problems affecting American men today. The authors' goal was to assess the impact of obesity on clinical and pathologic features of prostate cancer and long-term outcomes...
  51. ncbi Daily activities and survival at older ages
    Petra L Klumb
    Department of Psychology, University of Fribourg, Rue de Faucigny 2, 1700 Fribourg, Switzerland
    J Aging Health 19:594-611. 2007
    ..This study tested the hypothesis that time spent on activities that are considered regenerative (e.g., resting), productive (e.g., housework), and consumptive (e.g., meeting friends) is associated with survival in persons aged 70 and older.
  52. doi Lack of fibronectin-EDA promotes survival and prevents adverse remodeling and heart function deterioration after myocardial infarction
    Fatih Arslan
    Laboratory of Experimental Cardiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Circ Res 108:582-92. 2011
    ..The extracellular matrix protein fibronectin-EDA (EIIIA; EDA) is upregulated after tissue injury and may act as a "danger signal" for leukocytes to cause adverse cardiac remodeling after infarction...
  53. doi Prior exercise improves survival, infarct healing, and left ventricular function after myocardial infarction
    Monique C de Waard
    Experimental Cardiology, Dept of Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, The Netherlands
    J Appl Physiol (1985) 107:928-36. 2009
    We investigated the effects of voluntary wheel running before an acute myocardial infarction (MI) on survival, left ventricular (LV) remodeling and dysfunction and whether exercise before and after MI provides superior protection compared ..
  54. pmc Fractal characteristics of May-Grünwald-Giemsa stained chromatin are independent prognostic factors for survival in multiple myeloma
    Daniela P Ferro
    Department of Pathology, University of Campinas, Campinas, Brazil
    PLoS ONE 6:e20706. 2011
    ..In the present study we investigated the influence of the fractal dimension (FD) of chromatin on survival of patients with multiple myeloma.
  55. pmc CCR5 is essential for NK cell trafficking and host survival following Toxoplasma gondii infection
    Imtiaz A Khan
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Medical Center, New Orleans, Louisiana, USA
    PLoS Pathog 2:e49. 2006
    ..gondii infection and demonstrated that CCR5 is required for NK cell homing into infected liver and spleen. This study establishes CCR5 as a critical receptor guiding NK cell trafficking in host defense...
  56. doi Plasma chromogranin A as marker for survival in patients with metastatic endocrine gastroenteropancreatic tumors
    Rudolf Arnold
    Department of Internal Medicine, Division of Gastroenterology and Endocrinology, Philipps University, Marburg, Germany
    Clin Gastroenterol Hepatol 6:820-7. 2008
    ..We investigated the role of chromogranin A in predicting survival and hypothesized that chromogranin A mirrors tumor burden and that a rapid increase after a phase of stable ..
  57. pmc Folic acid supplementation can adversely affect murine neural tube closure and embryonic survival
    Amber Marean
    HHMI and Department of Pediatrics, Programs in Molecular Biology, University of Colorado AnschutzMedical Campus and Children s Hospital Colorado, Aurora, CO 80045, USA
    Hum Mol Genet 20:3678-83. 2011
    ..Our data indicate that, depending on the gene mutation, FA supplementation may adversely influence embryonic development and NT closure...
  58. ncbi Improved survival after resuscitation with norepinephrine in a murine model of uncontrolled hemorrhagic shock
    Marie Pierre Poloujadoff
    Hopital Avicenne, Assistance Publique Hopitaux de Paris, Universite Paris 13, France
    Anesthesiology 107:591-6. 2007
    ..However, studies on resuscitation using norepinephrine in uncontrolled hemorrhagic shock are lacking. The authors examined the effects of norepinephrine in combination with saline infusion in uncontrolled hemorrhage in rats...
  59. doi Adaptive memory: ancestral priorities and the mnemonic value of survival processing
    James S Nairne
    Department of Psychological Sciences, Purdue University, West Lafayette, IN 47907 2081, USA
    Cogn Psychol 61:1-22. 2010
    ..This prediction was examined in four experiments using the survival processing paradigm, in which retention is tested after participants process information in terms of its ..
  60. doi Adaptive memory: determining the proximate mechanisms responsible for the memorial advantages of survival processing
    Daniel J Burns
    Department of Psychology, Union College, Schenectady, NY12308, USA
    J Exp Psychol Learn Mem Cogn 37:206-18. 2011
    ..to help us remember fitness-relevant information and showed that retention of words rated for their relevance to survival is superior to that of words encoded under other deep processing conditions...
  61. ncbi Genetic analysis of hyperoxic acute lung injury survival in reciprocal intercross mice
    Daniel R Prows
    Department of Pediatrics, University of Cincinnati College of Medicine, Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Physiol Genomics 30:271-81. 2007
    ..and resistant 129X1/SvJ mice) to assess the genetic complexity of HALI and to identify genes affecting strain survival differences...
  62. pmc To be or not to be, the level of autophagy is the question: dual roles of autophagy in the survival response to starvation
    Chanhee Kang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Autophagy 4:82-4. 2008
    ..Since autophagy was discovered, it has been thought to act as a pro-survival response to several stresses, especially starvation, at the cell and organism levels by providing recycled ..
  63. ncbi Correlations of cell cycle regulators (p53, p21, pRb and mdm2) and c-erbB-2 with biological markers of proliferation and overall survival in breast cancer
    António E Pinto
    Departamento de Patologia Morfologica, Instituto Portugues de Oncologia de Francisco Gentil, Centro Regional Oncológico de Lisboa, SA, Portugal
    Pathology 37:45-50. 2005
    ..study was to investigate the correlations of several cell cycle modulators (p53, p21, pRb, and mdm2) and c-erbB-2 expression with cell proliferation markers (S-phase fraction [SPF] and Ki-67) and overall survival in breast cancer.
  64. ncbi Parenteral nutrition prolongs the survival of patients associated with malignant gastrointestinal obstruction
    Bo Guang Fan
    Department of Surgery, Wenzhou Medical College, Taizhou Hospital, Zhejiang, China
    JPEN J Parenter Enteral Nutr 31:508-10. 2007
    ..Parenteral nutrition (PN) is indicated in patients with a dysfunctional GI tract, but the role of PN in patients' survival is still controversial...
  65. pmc Combination therapy with a second-generation androgen receptor antagonist and a metastasis vaccine improves survival in a spontaneous prostate cancer model
    Andressa Ardiani
    Authors Affiliations Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland Medivation Inc, San Francisco, California and GlobeImmune Inc, Louisville, Colorado
    Clin Cancer Res 19:6205-18. 2013
    ..Immunotherapy has been shown to be a promising strategy for prostate cancer. This study was performed to provide data to support the combination of enzalutamide and immunotherapy for CRPC treatment...
  66. doi Vitamin antioxidants, lipid peroxidation, tumour stage, the systemic inflammatory response and survival in patients with colorectal cancer
    Elaine Y L Leung
    University Department of Surgery, Glasgow Royal Infirmary, Glasgow G31 2ER, United Kingdom
    Int J Cancer 123:2460-4. 2008
    ..between lipid-soluble antioxidant vitamins, lipid peroxidation, the systemic inflammatory response and survival in patients with primary operable (n = 53) and advanced inoperable (n = 53) colorectal cancer...
  67. doi Retrolective studies on the survival of cancer patients treated with mistletoe extracts: a meta-analysis
    Thomas Ostermann
    Center for Integrative Medicine, Department of Health, Witten Herdecke University, Herdecke, Germany
    Explore (NY) 8:277-81. 2012
    ..are actively seeking supportive treatments and may use distinct coping strategies that might be helpful to extend survival time...
  68. ncbi Elevated preoperative serum levels of angiogenic cytokines correlate to larger primary tumours and poorer survival in non-small cell lung cancer patients
    Daniel Brattstrom
    Department of Oncology, Uppsala University Hospital, University of Uppsala, S 751 85, Uppsala, Sweden
    Lung Cancer 37:57-63. 2002
    ..44; P<0.001). We conclude that elevated circulating angiogenic cytokines correlate with tumour volume, higher relapse risk and poorer survival in patients with operable non-small cell lung cancer.
  69. pmc Timing of hemoconcentration during treatment of acute decompensated heart failure and subsequent survival: importance of sustained decongestion
    Jeffrey M Testani
    Department of Internal Medicine and Program of Applied Translational Research, Yale University School of Medicine, New Haven, CT 06510, USA
    J Am Coll Cardiol 62:516-24. 2013
    This study sought to determine if the timing of hemoconcentration influences associated survival.
  70. doi Socioeconomic deprivation and survival after stroke: findings from the prospective South London Stroke Register of 1995 to 2011
    Ruoling Chen
    From the Division of Health and Social Care Research, King s College London, London, United Kingdom R C, C M, A G R, C D A W and National Institute for Health Research Comprehensive Biomedical Research Centre, Guy s and St Thomas National Health Service NHS Foundation Trust and King s College London, United Kingdom A G R, C D A W
    Stroke 45:217-23. 2014
    Previous findings of the association between socioeconomic deprivation (SED) and survival after stroke are inconsistent. There is less investigation on long-term survival...
  71. pmc Suppressing an anti-inflammatory cytokine reveals a strong age-dependent survival cost in mice
    Virginia Belloni
    Biogéosciences, Unité Mixte de Recherche 5561, Centre National de la Recherche Scientifique, Universite de Bourgogne, Dijon, France
    PLoS ONE 5:e12940. 2010
    ..Indeed, variation in regulation may strongly modulate the negative outcome of immune activation, with potentially important fitness consequences...
  72. pmc Impact of cabazitaxel on 2-year survival and palliation of tumour-related pain in men with metastatic castration-resistant prostate cancer treated in the TROPIC trial
    A Bahl
    Bristol Haematology and Oncology Centre, University Hospitals Bristol NHS Foundation Trust, Bristol, UK
    Ann Oncol 24:2402-8. 2013
    Cabazitaxel significantly improves overall survival (OS) versus mitoxantrone in patients with metastatic castration-resistant prostate cancer after docetaxel failure...
  73. ncbi A review of survival of pathogenic bacteria in organic waste used in biogas plants
    Leena Sahlström
    National Veterinary Institute, SE 75189 Uppsala, Sweden
    Bioresour Technol 87:161-6. 2003
    ..It is of greatest importance that the treatment in the biogas plants (BGPs) minimise the survival of pathogens...
  74. ncbi Tissue kallikrein increases duration of survival after prolonged coronary artery ligation in hypertensive rats
    Jagdish N Sharma
    Department of Applied Therapeutics, Faculty of Pharmacy, Health Sciences Center, Kuwait University, Safat, Kuwait
    Pharmacology 70:201-5. 2004
    ..study was designed to examine the effect of tissue kallikrein and Trasylol, an inhibitor of tissue kallikrein, on survival time after continuous (prolonged) coronary artery ligation in spontaneously hypertensive rats (SHR)...
  75. ncbi Why people 'freeze' in an emergency: temporal and cognitive constraints on survival responses
    John Leach
    Department of Psychology, University of Lancaster, Lancaster LA1 4YF, UK
    Aviat Space Environ Med 75:539-42. 2004
    ..Frequently witnesses report victims 'freezing' in the face of danger...
  76. ncbi Creatine improves health and survival of mice
    A Bender
    Department of Neurology, University of Munich, Klinikum Grosshadern, Marchioninistr 15, Munich D 81377, Germany
    Neurobiol Aging 29:1404-11. 2008
    ..These data show that Cr improves health and longevity in mice. Cr may be a promising food supplement to promote healthy human aging...
  77. ncbi Population dynamics in a long-lived seabird: I. Impact of breeding activity on survival and breeding probability in unbanded king penguins
    Céline Le Bohec
    Departement d Ecologie, Physiologie et Ethologie, Institut Pluridisciplinaire Hubert Curien, Strasbourg, France
    J Anim Ecol 76:1149-60. 2007
    Understanding the trade-off between current reproductive effort, future survival and future breeding attempts is crucial for demographic analyses and life history studies...
  78. doi Social and maternal factors affecting duckling survival in eiders Somateria mollissima
    Markus Ost
    Aronia, Coastal Zone Research Team, Raseborgsvägen 9, FI 10600 Ekenäs, Finland
    J Anim Ecol 77:315-25. 2008
    ..the aid of a novel survivorship model, an 8-year field study of social and maternal factors affecting duckling survival in eiders (Somateria mollissima) revealed that duckling survival probability varies in accordance with maternal ..
  79. doi Effect of environmental factors on survival and growth of quahog parasite unknown (QPX) in vitro
    Mickael Perrigault
    School of Marine and Atmospheric Sciences, Stony Brook University, Stony Brook, NY 11794 5000, USA
    J Invertebr Pathol 104:83-9. 2010
    ..major environmental parameters (temperature, salinity and oxygen concentration; individually or combined) on QPX survival in artificial seawater and parasite growth in culture media in vitro...
  80. doi Ventricular remodeling and survival are more favorable for myocarditis than for idiopathic dilated cardiomyopathy in childhood: an outcomes study from the Pediatric Cardiomyopathy Registry
    Susan R Foerster
    Washington University at St Louis, 1 Children s Place, St Louis, MO 63110, USA
    Circ Heart Fail 3:689-97. 2010
    ..Myocarditis is a cause of a new-onset dilated cardiomyopathy phenotype in children, with small studies reporting high rates of recovery of left ventricular (LV) function...
  81. doi Clinical outcomes of a comprehensive integrated program for HIV-exposed infants: a 3-year experience promoting HIV-free survival in rural Rwanda
    Neil Gupta
    Partners In Health, Rwinkwavu, Rwanda Division of Global Health Equity, Department of Medicine, Brigham and Women s Hospital, Boston, MA Department of Medicine, Children s Hospital Boston, Boston, MA Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA HIV AIDS, STIs and Other Blood Borne Infections Division, Rwanda Biomedical Center, Kigali, Rwanda
    J Acquir Immune Defic Syndr 62:e109-14. 2013
    Prevention of mother-to-child transmission of HIV services are often inadequate in promoting HIV-free child survival in rural areas with limited resources...
  82. ncbi Relationship between 18 FDG PET-CT findings and the survival of 177 patients with malignant pleural mesothelioma
    A Abakay
    Department of Chest Disease, Dicle University, Diyarbakir, Turkey
    Eur Rev Med Pharmacol Sci 17:1233-41. 2013
    ..We aimed to investigate the relationship between the pre-treatment 18 FDG PET/CT results, together with other known clinical parameters, and the survival of patients with MPM in our region.
  83. pmc Asparagine synthetase is an independent predictor of surgical survival and a potential therapeutic target in hepatocellular carcinoma
    B Zhang
    International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, 225 Changhai Road, Shanghai 200438, People s Republic of China
    Br J Cancer 109:14-23. 2013
    ..In this study, the relationship between ASNS expression and clinical outcomes after surgical resection was investigated, and the therapeutic value of ASNS was also evaluated...
  84. doi Combined immunostimulatory monoclonal antibodies extend survival in an aggressive transgenic hepatocellular carcinoma mouse model
    Aizea Morales-Kastresana
    Authors Affiliations Centro de Investigación Médica Aplicada CIMA, Universidad de Navarra Department of Oncology, Clinica Universidad de Navarra Liver Unit, Clínica Universidad de Navarra and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Pamplona, Spain Oncology Drug Discovery division, Bristol Myers Squibb, Lawrenceville, New Jersey and Department of Pathology, University of Bonn, Bonn, Germany
    Clin Cancer Res 19:6151-62. 2013
    ....
  85. ncbi gfp-Tagged cells as a useful tool to study the survival of Escherichia coli in the presence of the river microbial community
    I Arana
    Faculdad de Ciencias, Departamento de Inmunologia, Microbiologia y Parasitologia, Universidad del Pais Vasco, Apdo 644, E 48080 Bilbao, Spain
    Microb Ecol 45:29-38. 2003
    We have used an Escherichia coli strain DH5a containing pGreenTIR to study the survival of this bacterium in river water. As green fluorescence was maintained throughout survival both in dark and illuminated conditions, gfp-tagged E...
  86. ncbi Survival with full neurologic recovery after prolonged cardiopulmonary resuscitation with a combination of vasopressin and epinephrine in pigs
    Karl H Stadlbauer
    Department of Anesthesiology and Critical Care Medicine, Leopold Franzens University, Innsbruck, Austria
    Anesth Analg 96:1743-9, table of contents. 2003
    ..In conclusion, in this porcine model of prolonged CPR, repeated vasopressin/epinephrine administration, but not epinephrine or saline placebo alone, ensured long-term survival with full neurologic recovery.
  87. pmc Climate change and seal survival: evidence for environmentally mediated changes in elephant seal, Mirounga leonina, pup survival
    Clive R McMahon
    Australian Antarctic Division, Channel HWY, Kingston 7050, Tasmania, Australia
    Proc Biol Sci 272:923-8. 2005
    ..mechanisms by which physical factors and primary productivity could influence life-history traits, such as survival of apex predators, includes direct influences such as food availability and foraging success and indirect ..
  88. doi Prolonged survival to adulthood of an individual with hydranencephaly
    Jong Seok Bae
    Department of Neurology, Inje University, College of Medicine, 633 165 Gaegeum dong, Busanjin Gu, Busan 614 735 Republic of Korea
    Clin Neurol Neurosurg 110:307-9. 2008
    ..Although rare, patients with prolonged survival have been reported...
  89. doi High serum thymidine kinase 1 level predicts poorer survival in patients with chronic lymphocytic leukemia
    Sergej N Konoplev
    Division of Pathology and Laboratory Medicine, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Clin Pathol 134:472-7. 2010
    ..We show that high serum TK1 levels predict poorer overall survival and correlate with unmutated immunoglobulin variable region genes, CD38 and ZAP-70 expression, and subsequent ..
  90. pmc Molecular signatures associated with Mx1-mediated resistance to highly pathogenic influenza virus infection: mechanisms of survival
    Cristian Cilloniz
    Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA
    J Virol 86:2437-46. 2012
    ..Our results suggest that Mx1(+/+) mice generate a protective antiviral response by controlling the expression of key modulator molecules associated with influenza virus lethality...
  91. doi Treatment of B cell lymphoma with chemotherapy plus rituximab: a survival benefit can be demonstrated in the routine data of a regional cancer registry
    Stefan W Krause
    Department of Hematology and Medical Oncology, University Hospital Erlangen, Erlangen, Germany
    Ann Hematol 91:561-70. 2012
    ..the Regensburg Tumor Center for B cell non-Hodgkin lymphomas diagnosed between 1998 and 2006 and compared overall survival of patients receiving any first-line chemotherapy with or without rituximab...
  92. doi Extent of resection in patients with glioblastoma: limiting factors, perception of resectability, and effect on survival
    Daniel Orringer
    Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosurg 117:851-9. 2012
    ..The goal of this study was to identify demographic, tumor-related, and technical factors that influence EOR and to define the relationship between the surgeon's impression of EOR and radiographically determined EOR...
  93. doi The role of p53 on survival of upper urinary tract urothelial carcinoma: a systematic review and meta-analysis
    Ja Hyeon Ku
    Department of Urology, Seoul National University Hospital, Seoul, Korea
    Clin Genitourin Cancer 11:221-8. 2013
    ..searched for bibliographic information of articles about p53 expression evaluated by immunohistochemistry and survival in UUTUC from inception until June 2012. Seven articles met the eligibility criteria for this systematic review...
  94. pmc Pathologic complete response to neoadjuvant chemotherapy with trastuzumab predicts for improved survival in women with HER2-overexpressing breast cancer
    M M Kim
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Ann Oncol 24:1999-2004. 2013
    ..We sought to determine the prognostic value of pathologic response to neoadjuvant chemotherapy with concurrent trastuzumab...
  95. doi Loss of p57 expression and RhoA overexpression are associated with poor survival of patients with hepatocellular carcinoma
    Tinghua Hu
    Department of Oncology, The First Affiliated Hospital, College of Medicine, Xi an Jiaotong University, Xi an, Shaanxi 71006, P R China
    Oncol Rep 30:1707-14. 2013
    ..HCC) tissue specimens and to determine a possible association with clinicopathological data and patient survival. A total of 80 HCC and corresponding distant normal tissue specimens were processed for immunohistochemical and ..
  96. ncbi The contribution of increased diabetes prevalence and improved myocardial infarction and stroke survival to the increase in treated end-stage renal disease
    Paul Muntner
    Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA
    J Am Soc Nephrol 14:1568-77. 2003
    ..6%) resulted from the higher prevalence of diabetes; 1775 (4.8%) from increased MI and stroke survival; and 2904 (7.9%) resulted from growth of the US population without these conditions...
  97. ncbi Prolonged survival in alveolar capillary dysplasia syndrome
    Christoph Licht
    Department of Paediatrics, Children s Hospital, University of Cologne, Joseph Stelzmann Strasse 9, 50924, Cologne, Germany
    Eur J Pediatr 163:181-2. 2004
  98. pmc The opportunistic pathogen Toxoplasma gondii deploys a diverse legion of invasion and survival proteins
    Xing W Zhou
    The W Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Biol Chem 280:34233-44. 2005
    ..apical secretory organelles (micronemes, dense granules, and rhoptries) play key roles in host cell invasion and survival during infection...
  99. pmc Environmental pollution has sex-dependent effects on local survival
    Tapio Eeva
    University of Turku, Section of Ecology, Department of Biology, Turku 20014, Finland
    Biol Lett 2:298-300. 2006
    Environmental pollutants cause a potential hazard for survival in free-living animal populations...
  100. ncbi Are extra-pair young better than within-pair young? A comparison of survival and dominance in alpine marmot
    Aurélie Cohas
    Université de Lyon Université Lyon 1 CNRS UMR 5558, Laboratoire de Biometrie et Biologie Evolutive, Villeurbanne F 69622, France
    J Anim Ecol 76:771-81. 2007
    ..Here, we test the 'genetic quality' hypothesis using multistate capture-recapture models to compare age-specific survival and access to dominance between EPY and WPY in the alpine marmot Marmota marmota, a socially monogamous mammal ..
  101. doi Cohort effects in red squirrels: the influence of density, food abundance and temperature on future survival and reproductive success
    Sébastien Descamps
    Centre d Etudes Nordiques, Universite du Quebec a Rimouski, 300 Allee des Ursulines, Rimouski, Quebec G5L 3A1, Canada
    J Anim Ecol 77:305-14. 2008
    ..influences of food availability, density and spring temperature experienced early in life on reproduction and survival of female squirrels during adulthood. 3...

Research Grants85

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..CNTF is a natural chemical found in the body that promotes survival and function of nerve cells...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..CNTF is a natural chemical found in the body that promotes survival and function of nerve cells...
  3. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  4. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
  5. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  6. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
  7. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..cleaved myofibrils (4-6) and nuclear matrix protein poly ADP-ribose polymerase (PARP)-a DNA repair enzyme in cell survival during I/R (7). However, the regulation of intracellular MMPs during I/R is not known...
  8. Transcription factors regulating sensory gene expression and pain pathways
    Eric E Turner; Fiscal Year: 2011
    ..Using a conditional knockout strategy, we have shown that Islet1 is required for the differentiation and survival of a majority of nociceptive neurons...
  9. Xenoestrogen regulation of Leydig cells
    BENSON TOKUNBO AKINGBEMI; Fiscal Year: 2010
    ..regulation of Leydig cell mitosis is mediated by interaction of signaling pathways, which involves the cell survival factor protein Akt (protein kinase B) acting in concert with estrogen receptor ER1, epidermal growth factor ..
  10. Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductase
    STEPHEN WILLIAM TUTTLE; Fiscal Year: 2010
    ..Although advances in surgery, and combined of radio and chemotherapies, have decreased morbidity, the survival rate at 5 years after initial prognosis remains at <50%...
  11. Ian C Michelow; Fiscal Year: 2016
    ..modeling to account for repeated measures and confounding variables as well as the Cox proportional hazards survival model to compare time to predefined endpoints...
  12. Sogol Mostoufi-Moab; Fiscal Year: 2016
    ..g. longitudinal data analysis, clinical trial design, and survival analysis), (2) participation in the Childhood Cancer Survivor Study working groups for research activity, and (3) ..
  13. Role of NGF in inflammatory and proliferative cascades of psoriatic disease
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..NGF is FLS;TrkA is upregulated in FLS, endothelial cells and activated T cells;NGF regulates both activation and survival of CD4+/CD8+ T cells...
  14. FASEB SRC on Lysophospholipd Mediators in Health and Disease
    Julie D Saba; Fiscal Year: 2011
    ..LPA and S1P regulate chemotaxis, stress responses, cytoskeletal organization, calcium signaling, cell survival, apoptosis, autophagy, and gene transcription...
  15. Peroxynitrite Decomposition Catalyst and Nitric Oxide Donor for Endotoxemia
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..of endotoxinemia, resuscitation by R-100 starting 1 h after lipopolysaccharide (LPS) challenge produces 100% survival, accompanied by near complete protection against end-organ injury...
  16. Novel Mitochondrial Mechanisms of Ethanol-Induced Cardiac Injury in Aged Females
    DONNA HOPE KORZICK; Fiscal Year: 2010
    ..Because of the pivotal role played by the mitochondria in the maintenance of cell survival and cardioprotection, it is logical that ethanol and age-associated increases in I/R injury might arise from ..
  17. Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of Sclerod
    Robert B Zurier; Fiscal Year: 2012
    ..Current therapy is limited, with 10 year survival of 55%...
  18. KRISTEN RACHEL VELLA; Fiscal Year: 2014
    ..regulation of TH levels during periods of nutritional stress or illness is an important adaptive mechanism for survival. Metabolic signals are necessary to suppress TH levels to curb energy expenditure during a prolonged fast...
  19. Retinoid and Carotenoid Depletion in Patients at High-Risk for Liver Cancer
    Peter H Gann; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Median survival from a hepatocellular cancer (HCC) diagnosis is only 8 months;therefore, effective prevention strategies are a high priority...
  20. Patrice G Guyenet; Fiscal Year: 2015
    ..These reflexes are essential for survival because they quickly restore tissue oxygenation. Unfortunately, they are also a common source of human pathology...
  21. Soluble Epoxide Hydrolase as a Target for Ischemic Cardioprotection
    Donna M Van Winkle; Fiscal Year: 2012
    ..preliminary data show reduced infarct size in sEH deficient mice following induced heart attack, and improved survival of isolated heart muscle cells subjected to OGD, when treated with sEH inhibitor. Clinical Relevance...
  22. Role of Txnip in adapting fuel metabolism to nutritional state
    SIMON HUI; Fiscal Year: 2013
    The ability to properly respond to prolonged periods of nutritional scarcity is vital to the survival of all living organisms. Thioredoxin interacting protein (Txnip) is a key metabolic regulator of this important adaptation process...
  23. Pathogenesis and Treatment of Liver Disease in Transaldolase Deficiency
    Andras Perl; Fiscal Year: 2013
    ..We hypothesize that NADPH plays critical roles in the survival and multiplication of tumor cells in the liver...
  24. Sphingolipid Metabolism in Drosophila Development
    Julie D Saba; Fiscal Year: 2013
    ..interactions have been corroborated in murine C2C12 cells, indicating that SPL plays a conserved role in myoblast survival, fusion and differentiation...
  25. Polycyclic aromatic hydrocarbons and birth outcomes in Mexico City
    MARIE SYLVIA O'NEILL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The size and weight of a baby at birth are important determinants of its survival and future health across the life course...
  26. Randal J Kaufman; Fiscal Year: 2014
    ..The UPR is an adaptive signaling pathway to promote cell survival upon accumulation of unfolded protein in the endoplasmic reticulum (ER)...
  27. Neil W Kowall; Fiscal Year: 2014
    ..in motor neurons and cell death mediated by oxidative stress in vitro;2) To determine the role of LSD1 in the survival of motor neurons harboring the G93A SOD1 mutation;and 3) To investigate the therapeutic effect of LSD1 modulators ..
  28. Norma S Kenyon; Fiscal Year: 2015
    ..co-transplant protocol that can be tested in the clinical setting to improve long-term islet and renal allograft survival and function...
  29. REGULATION AND FUNCTION OF STE20-RELATED PROTEIN KINASES
    Melanie H Cobb; Fiscal Year: 2012
    ..multifunctional enzymes that have been found in screens to identify proteins required for development and survival, and that affect growth in flies, worms, and mammals. WNK1 is essential for embryonic development in mice...
  30. The role of Fli1 in T cell function and the pathogenesis of lupus
    Tamara K Nowling; Fiscal Year: 2011
    ..lowering the levels of Fli1 in two lupus prone mouse strains by 50% significantly improved disease and prolonged survival. Preliminary data generated in our laboratory indicates that Fli1 transcription fails to be turned off when T ..
  31. Mechanisms of action of ghrelin in muscle and adipose tissue in cancer-related ca
    Jose M Garcia; Fiscal Year: 2013
    ..Cachexia also contributes to a decrease in functional performance, quality of life and survival. However, treatments for this condition are lacking...
  32. Functional Genomics of the Mitochondrial Proteome
    Dennis R Winge; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Mitochondria are essential organelles for cellular metabolism and survival. As a result, mitochondrial dysfunction plays an important role in the pathophysiology of many metabolic disorders such as ..
  33. Role of Polyamines in MYCN-Amplified Neuroblastoma
    ANDRE BACHMANN; Fiscal Year: 2009
    ..proposal we outline studies that examine how MYCN, ODC, and polyamines regulate important cell cycle and cell survival pathways in NB cells...
  34. Translational Machinery in Stress Signaling and Tumor Suppression
    THOMAS J contact BEGLEY; Fiscal Year: 2010
    Adaptation and survival to strenuous environmental conditions are evolutionary conserved mechanisms that allow organisms to produce progeny...
  35. Insulin Signaling and the Heart in Diabetes
    EVAN DALE ABEL; Fiscal Year: 2011
    ..Although an increase in cardiac autophagy is essential for survival in the perinatal period prior to establishing regular feeding, it is effectively repressed once feeding ensues...
  36. Terence S Dermody; Fiscal Year: 2015
    ..or ablated solely in endothelial or hematopoietic cells will be infected with reovirus and monitored for survival, viral load, and pathologic injury...
  37. Robert T Means; Fiscal Year: 2014
    ..Three major processes are involved in the pathogenesis of ACD. A slight shortening of red cell survival creates a demand for a small increase in red cell production by the bone marrow...
  38. Role of IKK in NSCLC: Modulation of SMRT and NF-kappaB
    Marty W Mayo; Fiscal Year: 2012
    ..Non-small cell lung cancer (NSCLC) is the most common form of lung cancer. The 5-year mean survival for patients suffering from stage III lung cancer is less than 30%...
  39. Group A Streptococcus responses to oxidative stress
    Ioannis Gryllos; Fiscal Year: 2010
    ..The data obtained will further our understanding of the GAS adaptation mechanism(s) and survival in the host, and may uncover candidate target molecules and/or pathways for future investigations towards vaccine ..
  40. Trichothecene Toxicity and the Ribotoxic Stress Response
    James J Pestka; Fiscal Year: 2012
    ..HEALTH RELEVANCE: We propose to learn how a class of potent biological toxins interferes with the function and survival of cells that are essential to the immune system...
  41. Junxuan Lu; Fiscal Year: 2014
    ..and inactivating the Stat3 oncogenic signaling, associated with cyclin D1 (cell cycle) and Bcl-xL/Mcl-1 (cell survival) down regulation...
  42. Rajvir Dahiya; Fiscal Year: 2015
    ..Assays include cell proliferation, flow cytometry, migration, clonogenic survival, in vitro invasion and apoptosis assays...
  43. Kazem M Azadzoi; Fiscal Year: 2016
    ..In preliminary studies, we found that chronic bladder ischemia activated redox survival signaling via phosphoinositide 3-kinase (PI3-Kinase)/protein kinase B (Akt) pathway in smooth muscle cells and ..
  44. Maria Diakonova; Fiscal Year: 2014
    ..We showed that JAK2 binds to PAK1 and makes PAK1 more active. Activated PAK1 contributes to better cell survival and cell migration...
  45. Controlling Radiation Injury by TLR5 Agonists
    Andrei V Gudkov; Fiscal Year: 2012
    ..agonist of Toll-like receptor 5 (TLR5), is a powerful radioprotectant and radiomitigator capable of improving survival when given either before or after lethal IR, respectively...
  46. Regulation of epithelial cell homeostasis by actin microfilaments
    Seema Khurana; Fiscal Year: 2010
    ..However, few studies have established a causal link between microfilament reorganization and cell survival. Villin is an actin regulatory protein expressed in the gastrointestinal epithelial cells of the small and large ..
  47. ANIL KUMAR JAISWAL; Fiscal Year: 2014
    ..INrf2 interaction with PGAM5/BclXL/Bcl2, HSP90, and pICln and its significance in cellular protection and cell survival/death...
  48. Tat and CDK9 on gene expression alterations coupled to HIV-1 Associated Dementia
    Xavier Grana; Fiscal Year: 2010
    ..Also, increased survival rates resulting from HAART have led to an increase in the prevalence of neurological disorders...
  49. Pathobiology of Cystic Fibrosis-Related Diabetes in a Ferret Model
    Zoe Stewart; Fiscal Year: 2013
    ..effective treatment of CFRD will lead to reduced nutritional complications in CF ferrets, increased long-term survival, and reduced severity of lung disease...
  50. Inderjit Singh; Fiscal Year: 2014
    ..intracellular energy sensor switch which helps regulate glucose and lipid metabolism, in the context of the survival and differentiation of oligodendrocyte (OP) progenitor cells (OPCs) in an experimental autoimmune ..
  51. Vascular dysfunction and oxidative stress in primary amyloidosis
    RAYMOND QUEZON MIGRINO; Fiscal Year: 2010
    ..Untreated, patients with heart failure have median survival of 4-8 months, yet these patients are often ineligible for life-saving high dose chemotherapy and autologous stem ..
  52. DEBROSKI R HERBERT; Fiscal Year: 2016
    ..Schistosoma pathogenesis is remarkably similar in humans and mice, both of which require TH2 responses for survival during the acute phase of infection...
  53. MATTHEW PETER COGGINS; Fiscal Year: 2014
    ..factors regulates a wide range of essential processes in multiple tissues, from inflammation to cell survival. In the heart, while it is known that NF-kB is involved in hypertrophy, ventricular remodeling, and ischemic ..
  54. CHIH CHANG KEVIN WEI; Fiscal Year: 2014
    ..degrade fibronectin (7), an important component of the focal adhesion complex that controls cell growth and survival. ISF BK and kallikrein gene expression, as well as increased MCs and chymase activity, are increased at both ..
  55. DAVID MATTHEW KELLER; Fiscal Year: 2016
    ..Cyclic-AMP also promotes long-term changes in [unreadable]-cell function, growth, and survival through regulation of gene expression (Hinke et al., 2004), not all of which are completely understood...
  56. Enzymatic Regulation of S-Glutathionylation : Role in Apoptosis and Disease
    John J Mieyal; Fiscal Year: 2012
    ..the glutaredoxin or thioredoxin enzymes are altered by L-DOPA treatment of neurons that cause them to switch from survival mode to programmed cell death? 2...
  57. Junichi Sadoshima; Fiscal Year: 2016
    ..2. GSK-3b regulates survival and death of cardiomyocytes during I/R...
  58. Subhash C Pandey; Fiscal Year: 2014
    ..Brain-derived neurotrophic factor (BDNF) plays a role in neuronal survival, differentiation, and consolidation of synaptic strength...
  59. ANDREW GREGORY SIKORA; Fiscal Year: 2015
    ..We will determine whether iNOS inhibition decreases intratumoral MDSC numbers by affecting their trafficking, survival, or differentiation, or through a combination of these mechanisms...
  60. Thomas L Clemens; Fiscal Year: 2016
    ..The contemporary view is that IGFs serve dominant roles in cell proliferation, survival and organismal growth, whereas insulin's primaryfunctionsinclude the regulation of fuel accumulation, ..
  61. A MicroRNA Approach to Screen for Sporadic Colon Cancer Exfoliately in Human Stoo
    Farid E Ahmed; Fiscal Year: 2010
    ..Five-year survival rates are strikingly different by stage ranging from 90% for localized disease to 10% for distant disease, ..
  62. Twenty-second Annual Fanconi Anemia Research Fund Scientific Symposium
    GROVER CARLTON BAGBY; Fiscal Year: 2010
    ..There is in vitro and in vivo evidence that at least some of the FA proteins also promote survival signaling pathways in hematopoietic cells by forming complexes with signaling molecules...
  63. A Novel Drug for Septicemia Targets A1 ARs
    Constance Neely Wilson; Fiscal Year: 2010
    ..Administration of L-97-1 as a single intravenous (i.v.) infusion in high doses post-CLP improved seven day survival in a dose-dependent manner (30-40% survival) vs...
  64. Genetic Control of Axial Patterning in Drosophila Eye
    Amit Singh; Fiscal Year: 2010
    ..L is required for ventral eye development, growth, and survival. To understand the molecular genetic basis of L functions in cell survival, specification and growth, we will use ..
  65. Nitric Oxide in Pulmonary Hypertension
    Serpil Erzurum; Fiscal Year: 2009
    ..We found that PAH PAEC have enhanced proliferation &survival, which is dependent on activation of signal transducer and activator of transcription-3 (STAT3), a fundamental ..
  66. Anti-HLA Antibody Activation of Endothelial Cells in Cardiac Transplantation
    Elaine F Reed; Fiscal Year: 2010
    ..initiates intracellular signals in endothelial cells that synergize with growth factor receptors to elicit cell survival and cell proliferation...
  67. Fatty Acid Synthase Inhibitors: Ovarian Cancer Therapy
    ALBERT OWENS; Fiscal Year: 2007
    ..Screening markers and therapies remain limited, and 5-year survival rates for the 60% of women diagnosed with Stage III or IV disease are less than 20%...
  68. NOVEL FACTORS THAT REGULATE GNRH NEURONAL DEVELOPMENT
    Margaret E Wierman; Fiscal Year: 2010
    ..Gas6 activation of Axl and Tyro3 promotes GnRH neuronal cell migration and survival. Axl/Tyro3 null mice demonstrate delayed first estrus, abnormal estrus cyclicity and prolonged proestrus...
  69. Novel Screen for Targeted CLL Therapeutics
    Dale Christensen; Fiscal Year: 2009
    ..Tumor cells from B-CLL patients show increased survival rates that have been shown to be due to inhibited apoptosis and alterations of genes involved in cell cycle ..
  70. Regulation of neurotrophin expression in the periphery
    LORI ISAACSON; Fiscal Year: 2009
    ..provided by applicant): The underlying hypothesis of the present study is that neurotrophins regulate the survival of peripheral neurons...
  71. Molecular Characterization of Stage I Lung Cancer
    Ming You; Fiscal Year: 2010
    ..chemotherapy in an unselected group of patients with resected stage l-lll produces only modest improvement in survival. It is critical to develop molecular predictors for recurrence...
  72. M. tuberculosis survival in Macrophages
    Richard Friedman; Fiscal Year: 2003
    ..of macrophages by Mycobacterium tuberculosis can be divided into four steps: adherence, entry, intracellular survival, and multiplication. This proposal will concentrate on one of these steps, survival...
  73. Ethnic Differences in Survival after Childhood ALL
    Smita Bhatia; Fiscal Year: 2009
    ..by applicant): Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy, with a five-year survival rate approaching 80%. We have shown highly significant differences in survival among ethnic and racial groups...
  74. Pathogenic Roles of Coxiella burnetti Proteins
    James Samuel; Fiscal Year: 2007
    ..We propose that survival mechanisms are the principle virulence determinants of C. bumetii...
  75. Molecular Epidemiology of non-Hodgkin Lymphoma Survival
    James R Cerhan; Fiscal Year: 2010
    ..b>Survival rates have only recently begun to improve, and the current 5-year survival rate is 66%...
  76. Discovery of exon, microRNA and clinical prognostic markers of glioblastoma survi
    SANDRA L RODRIGUEZ ZAS; Fiscal Year: 2010
    ..the United States are diagnosed with Glioblastoma multiforme, the most common primary brain tumor, and the median survival (irrespective of therapy) is one year...
  77. Lenalidomide Treatment and the Chronic Lymphocytic Leukemia Microenvironment
    Thomas J Kipps; Fiscal Year: 2010
    ..the biology of CLL has revealed that accessory cells in the leukemia microenvironment can promote leukemia-cell survival and resistance to chemotherapy in vitro, and presumably in vivo...
  78. Endothelial and head & neck cancer stem cell crosstalks and resistance to therapy
    Jacques Nor; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The 5-year survival of patients with advanced head and neck cancer with current therapeutic protocols is very low...
  79. M TUBERCULOSIS SURVIVAL IN MACROPHAGES
    Richard Friedman; Fiscal Year: 1999
    ..of macrophages by Mycobacterium tuberculosis can be divided into four steps: adherence, entry, intracellular survival, and multiplication. The aim of the proposed research is to identify, clone, and characterize genes of M...