rem sleep

Summary

Summary: A stage of sleep characterized by rapid movements of the eye and low voltage fast pattern EEG. It is usually associated with dreaming.

Top Publications

  1. ncbi Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation
    R M Chemelli
    Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, 75235 9050, USA
    Cell 98:437-51. 1999
  2. ncbi The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene
    L Lin
    Center for Narcolepsy, Department of Psychiatry, Stanford University School of Medicine, California 94305 5485, USA
    Cell 98:365-76. 1999
  3. ncbi The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation
    Hans P A Van Dongen
    Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, Department of Psychiatry, and Centerfor Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    Sleep 26:117-26. 2003
  4. ncbi Learning-dependent increases in sleep spindle density
    Steffen Gais
    Department of Neuroendocrinology, University of Lubeck, 23564 Lübeck, Germany
    J Neurosci 22:6830-4. 2002
  5. ncbi Sleep, learning, and dreams: off-line memory reprocessing
    R Stickgold
    Laboratory of Neurophysiology and Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
    Science 294:1052-7. 2001
  6. ncbi Sleep loss and REM sleep loss are hyperalgesic
    Timothy Roehrs
    Henry Ford Health System, Sleep Disorders and Research Center, Detroit, MI 48202, USA
    Sleep 29:145-51. 2006
  7. ncbi Why do we sleep?
    T J Sejnowski
    Howard Hughes Medical Institute and the Salk Institute, 10010 North Torrey Pines Road, 92037, La Jolla, CA, USA
    Brain Res 886:208-223. 2000
  8. ncbi REM sleep: a sensitive index of fear conditioning in rats
    Sushil K Jha
    Medical Research Service 151, Philadelphia VA Medical Center, Philadelphia, USA
    Eur J Neurosci 21:1077-80. 2005
  9. ncbi Experience-dependent changes in cerebral activation during human REM sleep
    P Maquet
    Cyclotron Research Centre, University of Liege, Belgium
    Nat Neurosci 3:831-6. 2000
  10. ncbi Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes
    Jon T Willie
    Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Neuron 38:715-30. 2003

Detail Information

Publications300 found, 100 shown here

  1. ncbi Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation
    R M Chemelli
    Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, 75235 9050, USA
    Cell 98:437-51. 1999
    ..We propose that orexin regulates sleep/wakefulness states, and that orexin knockout mice are a model of human narcolepsy, a disorder characterized primarily by rapid eye movement (REM) sleep dysregulation...
  2. ncbi The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene
    L Lin
    Center for Narcolepsy, Department of Psychiatry, Stanford University School of Medicine, California 94305 5485, USA
    Cell 98:365-76. 1999
    ..This result identifies hypocretins as major sleep-modulating neurotransmitters and opens novel potential therapeutic approaches for narcoleptic patients...
  3. ncbi The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation
    Hans P A Van Dongen
    Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, Department of Psychiatry, and Centerfor Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    Sleep 26:117-26. 2003
    ....
  4. ncbi Learning-dependent increases in sleep spindle density
    Steffen Gais
    Department of Neuroendocrinology, University of Lubeck, 23564 Lübeck, Germany
    J Neurosci 22:6830-4. 2002
    ..56; p < 0.05). Power spectra and time spent in sleep stages did not differ between learning and nonlearning conditions. Results indicate that spindle activity during non-REM sleep is sensitive to previous learning experience.
  5. ncbi Sleep, learning, and dreams: off-line memory reprocessing
    R Stickgold
    Laboratory of Neurophysiology and Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
    Science 294:1052-7. 2001
    ....
  6. ncbi Sleep loss and REM sleep loss are hyperalgesic
    Timothy Roehrs
    Henry Ford Health System, Sleep Disorders and Research Center, Detroit, MI 48202, USA
    Sleep 29:145-51. 2006
    ..We report the first data showing, in healthy, pain-free, individuals, that modest reductions of sleep time and specific loss of rapid eye movement (REM) sleep produces hyperalgesia the following morning...
  7. ncbi Why do we sleep?
    T J Sejnowski
    Howard Hughes Medical Institute and the Salk Institute, 10010 North Torrey Pines Road, 92037, La Jolla, CA, USA
    Brain Res 886:208-223. 2000
    ..This scenario provides a biophysical mechanism consistent with the growing evidence that sleep serves to consolidate memories...
  8. ncbi REM sleep: a sensitive index of fear conditioning in rats
    Sushil K Jha
    Medical Research Service 151, Philadelphia VA Medical Center, Philadelphia, USA
    Eur J Neurosci 21:1077-80. 2005
    ..Sleep efficiency (total sleep time/recording period) and REM sleep (REM) and non-REM (NREM) measures were determined...
  9. ncbi Experience-dependent changes in cerebral activation during human REM sleep
    P Maquet
    Cyclotron Research Centre, University of Liege, Belgium
    Nat Neurosci 3:831-6. 2000
    The function of rapid-eye-movement (REM) sleep is still unknown. One prevailing hypothesis suggests that REM sleep is important in processing memory traces...
  10. ncbi Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes
    Jon T Willie
    Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Neuron 38:715-30. 2003
    ..Both OX2R(-/-) and orexin(-/-) mice are similarly affected with behaviorally abnormal attacks of non-REM sleep ("sleep attacks") and show similar degrees of disrupted wakefulness...
  11. pmc Emotional memory formation is enhanced across sleep intervals with high amounts of rapid eye movement sleep
    U Wagner
    University of Bamberg, Department of Physiological Psychology, D 96045 Bamberg, Germany
    Learn Mem 8:112-9. 2001
    ..covering either early sleep known to be dominated by nonREM slow wave sleep (SWS) or late sleep, in which REM sleep is dominant...
  12. ncbi Pharmacological REM sleep suppression paradoxically improves rather than impairs skill memory
    Björn Rasch
    University of Lubeck, Department of Neuroendocrinology, Haus 23a, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Nat Neurosci 12:396-7. 2009
    ..Contrary to expectations, we found that REM sleep suppression by administration of selective serotonin or norepinephrine re-uptake inhibitors after training did ..
  13. ncbi Cerebral sympathetic nerve activity has a major regulatory role in the cerebral circulation in REM sleep
    Priscila A Cassaglia
    Ritchie Centre for Baby Health Research, Monash Institute of Medical Research, Monash University, Melbourne, Australia
    J Appl Physiol (1985) 106:1050-6. 2009
    ..Similar SNA increases to cerebral blood vessels may regulate the cerebral circulation in REM sleep, but this is unknown...
  14. ncbi Sleep and posttraumatic stress disorder: a review
    Allison G Harvey
    Department of Experimental Psychology, University of Oxford, OX1 3UD, UK
    Clin Psychol Rev 23:377-407. 2003
    ..Areas for future research are specified. In particular, a priority is to improve the methodology of the research conducted...
  15. ncbi Chronic behavioral disorders of human REM sleep: a new category of parasomnia
    C H Schenck
    Minnesota Regional Sleep Disorders Center, Hennepin County Medical Center, University of Minnesota, Minneapolis 55415
    Sleep 9:293-308. 1986
    ..Polysomnography did not detect seizures but did document REM sleep pathology with variable loss of chin atonia, extraordinarily increased limb-twitch activity, and increased REM ..
  16. ncbi Intermittent hypoxia causes REM sleep deficits and decreases EEG delta power in NREM sleep in the C57BL/6J mouse
    Vsevolod Y Polotsky
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Sleep Med 7:7-16. 2006
    ..We hypothesized that both intermittent hypoxia (IH) and non-hypoxic arousals of OSA result in significant disruption of non-rapid eye movement sleep (NREMS) and rapid eye movement sleep (REMS)...
  17. ncbi Long-term vs. short-term processes regulating REM sleep
    Paul Franken
    Institute of Pharmacology, University of Zurich, Zurich, Switzerland
    J Sleep Res 11:17-28. 2002
    ..The SD induced changes in sleep architecture could be reproduced by assuming that the increased long-term REMS pressure interacts with the short-term process by increasing the probability to enter and remain in REMS...
  18. pmc Long-term effect of cued fear conditioning on REM sleep microarchitecture in rats
    Vibha Madan
    Laboratory for Study of the Brain in Sleep, Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104 6045, USA
    Sleep 31:497-503. 2008
    To study long-term effects of conditioned fear on REM sleep (REMS) parameters in albino rats.
  19. ncbi A review of mentation in REM and NREM sleep: "covert" REM sleep as a possible reconciliation of two opposing models
    T A Nielsen
    Sleep Research Center, Hopital du Sacre Coeur de Montreal, Montreal, Quebec, Canada and Psychiatry Department, Universite de Montreal, Quebec H4J 1C5, Canada
    Behav Brain Sci 23:851-66; discussion 904-1121. 2000
    ..attempt to reconcile the two models, an alternative model is proposed that assumes the existence of covert REM sleep processes during NREM sleep...
  20. pmc Severity of REM atonia loss in idiopathic REM sleep behavior disorder predicts Parkinson disease
    R B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Canada
    Neurology 74:239-44. 2010
    Over 50% of persons with idiopathic REM sleep behavior disorder (RBD) will develop Parkinson disease (PD) or dementia. At present, there is no way to predict who will develop disease...
  21. pmc The developmental decrease in REM sleep: the role of transmitters and electrical coupling
    Edgar Garcia-Rill
    Center for Translational Neuroscience, Department of Neurobiology and Developmental Science, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Sleep 31:673-90. 2008
    ....
  22. ncbi Clues to the functions of mammalian sleep
    Jerome M Siegel
    Neurobiology Research 151A3, VA GLAHS Sepulveda, Department of Psychiatry and Brain Research Institute, UCLA School of Medicine, North Hills, California 91343, USA
    Nature 437:1264-71. 2005
    ..Theories of REM sleep have suggested a role for this state in periodic brain activation during sleep, in localized recuperative ..
  23. ncbi Grouping of spindle activity during slow oscillations in human non-rapid eye movement sleep
    Matthias Mölle
    Institute of Neuroendocrinology, University of Lubeck, 23538 Lubeck, Germany
    J Neurosci 22:10941-7. 2002
    ..The drive is particularly strong during cortical depolarization, expressed as surface-positive field potentials...
  24. ncbi Induction of hippocampal long-term potentiation during waking leads to increased extrahippocampal zif-268 expression during ensuing rapid-eye-movement sleep
    Sidarta Ribeiro
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 22:10914-23. 2002
    ..firing, regional blood flow, and expression of the activity-dependent gene zif-268 between WK and subsequent REM sleep. Zif-268 integrates a major calcium signal transduction pathway and is implicated by several lines of evidence ..
  25. ncbi Odor cues during slow-wave sleep prompt declarative memory consolidation
    Björn Rasch
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160 23a, 23538 Lubeck, Germany
    Science 315:1426-9. 2007
    ..Concurring with these findings, functional magnetic resonance imaging revealed significant hippocampal activation in response to odor re-exposure during SWS...
  26. ncbi Human brain activity time-locked to rapid eye movements during REM sleep
    Satoru Miyauchi
    Kobe Advanced ICT Research Center, National Institute of Information and Communications Technology NICT, 588 2 Iwaoka, Iwaoka cho, Nishi ku, Kobe, Hyogo, 651 2492, Japan
    Exp Brain Res 192:657-67. 2009
    To identify the neural substrate of rapid eye movements (REMs) during REM sleep in humans, we conducted simultaneous functional magnetic resonance imaging (fMRI) and polysomnographic recording during REM sleep...
  27. ncbi Human alpha oscillations in wakefulness, drowsiness period, and REM sleep: different electroencephalographic phenomena within the alpha band
    Jose L Cantero
    Laboratory of Neurophysiology, Department of Psychiatry, Harvard Medical School, Boston, USA
    Neurophysiol Clin 32:54-71. 2002
    ..among alpha activity spontaneously appearing in relaxed wakefulness with eyes closed, drowsiness period, and REM sleep, by reflecting distinct properties of neural networks involved in its cortical generation as well as a different ..
  28. ncbi The REM sleep-memory consolidation hypothesis
    J M Siegel
    Center for Sleep Research, Department of Veterans Affairs, Greater Los Angeles Healthcare System VA GLAHCS, North Hills, CA 91343, USA
    Science 294:1058-63. 2001
    ..Animal studies correlating changes in REM sleep parameters with learning have produced inconsistent results and are confounded by stress effects...
  29. ncbi The neurobiology of sleep: genetics, cellular physiology and subcortical networks
    Edward F Pace-Schott
    Laboratory of Neurophysiology, Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center, 74 Fenwood Road, Boston, Massachusetts 02115, USA
    Nat Rev Neurosci 3:591-605. 2002
  30. ncbi Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity
    J Hara
    Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Neuron 30:345-54. 2001
    ..Orexin/ataxin-3 mice provide a valuable model for studying the pathophysiology and treatment of narcolepsy...
  31. ncbi REM sleep and the early development of posttraumatic stress disorder
    Thomas A Mellman
    Department of Psychiatry, Dartmouth School of Medicine, One Medical Center Drive, Lebanon, NH 03756, USA
    Am J Psychiatry 159:1696-701. 2002
    ..recordings during an acute period after life-threatening experiences and injury and to relate measures of sleep duration and maintenance and the timing, intensity, and continuity of REM sleep to the early development of PTSD.
  32. pmc Theta and gamma coordination of hippocampal networks during waking and rapid eye movement sleep
    Sean M Montgomery
    Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey 07102, USA
    J Neurosci 28:6731-41. 2008
    ..To understand how intrahippocampal networks interact during REM sleep, we used 96 site silicon probes to record from different hippocampal subregions and compared the patterns of ..
  33. ncbi Localization of the GABAergic and non-GABAergic neurons projecting to the sublaterodorsal nucleus and potentially gating paradoxical sleep onset
    Romuald Boissard
    CNRS UMR5167, Institut Fédératif des Neurosciences de Lyon IFR 19, Universite Claude Bernard Lyon I, 7, Rue Guillaume Paradin, 69372 Lyon, Cedex 08, France
    Eur J Neurosci 18:1627-39. 2003
    ..They could also terminate on SLD GABAergic interneurons and be indirectly responsible for the inhibition of the PS-on neurons during waking and slow-wave sleep...
  34. pmc Circadian timing of REM sleep is coupled to an oscillator within the dorsomedial suprachiasmatic nucleus
    Michael L Lee
    Department of Biology and Program of Neurobiology and Behavior, University of Washington, P O Box 351800, Seattle, WA 98195 1800, USA
    Curr Biol 19:848-52. 2009
    ..We provide the first neurophysiological model for the disruption of sleep architecture that may result from temporal challenges such as rotational-shift work and jetlag...
  35. pmc REM sleep, prefrontal theta, and the consolidation of human emotional memory
    Masaki Nishida
    Sleep and Neuroimaging Laboratory Department of Psychology and Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94702 1650, USA
    Cereb Cortex 19:1158-66. 2009
    ..the Nap group, the extent of emotional memory facilitation was significantly correlated with the amount of REM sleep and also with right-dominant prefrontal theta power during REM...
  36. ncbi A survey screen for prediction of apnea
    G Maislin
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia 19104-4283, USA
    Sleep 18:158-66. 1995
    ..79 (p < 0.0001). For BMI alone, it was 0.73, and for an index measuring the self-report of the frequency of apnea symptoms, it was 0.70. The multivariable apnea risk index has potential utility in clinical settings...
  37. ncbi Influence of shock training and explicit fear-conditioned cues on sleep architecture in mice: strain comparison
    Larry D Sanford
    Sleep Research Laboratory, Department of Pathology and Anatomy, Eastern Virginia Medical School, Norfolk, Virginia 23501, USA
    Behav Genet 33:43-58. 2003
    ..Fear conditioning may provide a model for examining genetic and neural mechanisms underlying the influence of anxiety on sleep...
  38. ncbi Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle
    Maan Gee Lee
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, H3A 2B4, Canada
    J Neurosci 25:6716-20. 2005
    ..They increase firing before the end of PS and thereby herald by several seconds the return of waking and muscle tone. The orexin neurons would thus stimulate arousal, while antagonizing sleep and muscle atonia...
  39. ncbi Antidepressants and REM sleep in Wistar-Kyoto and Sprague-Dawley rats
    Magnus Ivarsson
    Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, UK
    Eur J Pharmacol 522:63-71. 2005
    Compared to other rat strains, the Wistar-Kyoto rats show increased amount of REM sleep, one of the characteristic sleep changes observed in depressed patients...
  40. ncbi Learned material content and acquisition level modulate cerebral reactivation during posttraining rapid-eye-movements sleep
    Philippe Peigneux
    Cyclotron Research Center and Department of Neuropsychology, Universite de Liege, Belgium
    Neuroimage 20:125-34. 2003
    ..Neurosci. 3 (2000) 831-836), suggesting that REM sleep participates in the reprocessing of recent memory traces in humans...
  41. ncbi Neurobiology of REM and NREM sleep
    Robert W McCarley
    Neuroscience Laboratory, VA Boston Healthcare System, 940 Belmont St, Brockton, MA 02301, USA
    Sleep Med 8:302-30. 2007
    ..emphasis on GABAergic mechanisms and a discussion of the role of orexin/hypcretin in diurnal consolidation of REM sleep. The focus of the NREM sleep discussion is on the basal forebrain and adenosine as a mediator of homeostatic ..
  42. ncbi Arousal thresholds during human tonic and phasic REM sleep
    Ummehan Ermis
    Department of Neurology, Goethe Universitat Frankfurt, Germany
    J Sleep Res 19:400-6. 2010
    ..These data provide further evidence that REM sleep should not be regarded a uniform state...
  43. ncbi Fear-conditioned suppression of REM sleep: relationship to Fos expression patterns in limbic and brainstem regions in BALB/cJ mice
    Xianling Liu
    Department of Pathology and Anatomy, Eastern Virginia Medical School, PO Box 1980, Norfolk, VA 23501 1980, USA
    Brain Res 991:1-17. 2003
    ..The data are discussed with respect to the putative role of brainstem nuclei in regulating REM and the role of the amygdala in conditioned fear...
  44. ncbi Hallucinations, REM sleep, and Parkinson's disease: a medical hypothesis
    I Arnulf
    centre d investigation clinique, Fédération de Neurologie and INSERM U 289
    Neurology 55:281-8. 2000
    Patients with PD can have disabling visual hallucinations associated with dopaminergic therapy. Sleep disorders, including vivid dreams and REM sleep with motor behaviors (RBD), are frequent in these patients.
  45. ncbi Wavelength-dependent effects of evening light exposure on sleep architecture and sleep EEG power density in men
    Mirjam Munch
    Centre for Chronobiology, Psychiatric Univ Clinics, University of Basel, Switzerland
    Am J Physiol Regul Integr Comp Physiol 290:R1421-8. 2006
    ..Thus the light effects on the dynamics of SWA and REM sleep durations were blue shifted relative to the three-cone visual photopic system probably mediated by the circadian,..
  46. ncbi EEG spectral analysis of wakefulness and REM sleep in high functioning autistic spectrum disorders
    Anne Marie Daoust
    Neurodevelopmental Disorders Program, Laboratoire du Sommeil, Centre de Recherche Fernand Seguin, Hôpital Rivière des Prairies, 7070 Boulevard Perras, Montreal, Quebec, Canada H1E 1A4
    Clin Neurophysiol 115:1368-73. 2004
    The aim of this study was to investigate the involvement of temporo-occipital regions in the pathophysiology of autistic spectrum disorders (ASD) by using REM sleep and waking EEG.
  47. ncbi The effects of REM sleep deprivation on the level of sleepiness/alertness
    K Nykamp
    Henry Ford Hospital, Sleep Disorders and Research Center, Detroit, Mich. 48202, USA
    Sleep 21:609-14. 1998
    ..On deprivation nights, RD subjects were awakened each time they entered stage REM sleep, and the YC subjects were awakened concomitantly with the RD subjects, assuming they were not in stage REM sleep...
  48. ncbi Overnight emotional adaptation to negative stimuli is altered by REM sleep deprivation and is correlated with intervening dream emotions
    Jessica Lara-Carrasco
    Sleep Research Center, Hôpital du Sacré Coeur, Universite de Montreal, Montreal H4J 1C5, Canada
    J Sleep Res 18:178-87. 2009
    ..To evaluate the impact of REM sleep deprivation (REMD) and the presence of dream emotions on a possible emotional adaptation (EA) function, 35 ..
  49. ncbi The effect of donepezil on sleep and REM sleep EEG in patients with Alzheimer disease: a double-blind placebo-controlled study
    Walterandré dos Santos Moraes
    Psychobiology Department, Universidade Federal de Sao Paulo, Brazil
    Sleep 29:199-205. 2006
    Examine the effects of donepezil on sleep and rapid eye movement (REM) sleep electroencephalogram (EEG) in patients with Alzheimer disease, using polysomnography, and the correlation between REM sleep EEG parameters and cognitive scores.
  50. ncbi A putative flip-flop switch for control of REM sleep
    Jun Lu
    Department of Neurology and Program in Neuroscience, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Nature 441:589-94. 2006
    ..Although REM sleep was discovered more than 50 years ago, the neuronal circuits responsible for switching between REM and non-REM (..
  51. ncbi REM sleep - by default?
    J A Horne
    Sleep Research Centre, Human Sciences Department, Loughborough University, LE11 3TU, Leicestershire, UK
    Neurosci Biobehav Rev 24:777-97. 2000
    Elements of three old, overlapping theories of REM sleep (REM) function, the Ontogenetic, Homeostatic and Phylogenetic hypotheses, together still provide a plausible framework - that REM (i) is directed towards early cortical development,..
  52. ncbi Effects of the CLIP fragment ACTH 20-24 on the duration of REM sleep episodes
    W Wetzel
    Federal Institute for Neurobiology, Magdeburg, Germany
    Neuropeptides 31:41-5. 1997
    ..We suggest that short N-terminal CLIP fragment(s) may represent endogenous hypnogenic factor(s) involved in the regulation of paradoxical sleep...
  53. pmc Cold exposure and sleep in the rat: REM sleep homeostasis and body size
    Roberto Amici
    Department of Human and General Physiology, Alma Mater Studiorum University of Bologna, Italy
    Sleep 31:708-15. 2008
    Exposure to low ambient temperature (Ta) depresses REM sleep (REMS) occurrence...
  54. ncbi Localized and lateralized cerebral glucose metabolism associated with eye movements during REM sleep and wakefulness: a positron emission tomography (PET) study
    C C Hong
    Department of Psychiatry, University of California, San Diego, La Jolla 92093-0603, USA
    Sleep 18:570-80. 1995
    ..Eye movement data were available on nine subjects studied during nighttime REM sleep and six control subjects studied during waking as they periodically moved their eyes...
  55. ncbi Mechanisms and models of REM sleep control
    R W McCarley
    From the Laboratory of Neuroscience, Harvard Department of Psychiatry at the VA Boston Healthcare System, Brockton, MA 02301, USA
    Arch Ital Biol 142:429-67. 2004
    ..the history and recent developments relevant to the major neurotransmitters and neuromodulators involved in REM sleep control...
  56. ncbi Effects of playing a computer game using a bright display on presleep physiological variables, sleep latency, slow wave sleep and REM sleep
    Shigekazu Higuchi
    Department of Public Health, Akita University School of Medicine, Akita, Japan
    J Sleep Res 14:267-73. 2005
    ..Sleep latency was significantly longer after playing games than after the control conditions. REM sleep was significantly shorter after the playing games than after the control conditions...
  57. ncbi Artificial neural network and wavelet based automated detection of sleep spindles, REM sleep and wake states
    Rakesh Kumar Sinha
    Department of Biomedical Instrumentation, Birla Institute of Technology, Mesra, Ranchi 835215, Jharkhand, India
    J Med Syst 32:291-9. 2008
    ..for the EEG epochs (64 data) were selected as inputs for the training the network and to classify SS, REM sleep and AWA stages...
  58. ncbi GABAergic regulation of REM sleep in reticularis pontis oralis and caudalis in rats
    Larry D Sanford
    Sleep Research Laboratory, Department of Pathology and Anatomy, Eastern Virginia Medical School, Norfolk 23501, USA
    J Neurophysiol 90:938-45. 2003
    ..0 microM) injected into RPO (n = 9) and RPC (n = 4) produced wakefulness and escape behavior. The results indicate that GABA in RPO/RPC is involved in the regulation of REM and suggest site-specific differences in this regulation...
  59. pmc Spontaneous arousal activity in infants during NREM and REM sleep
    Frances McNamara
    Edward Mallinckrodt Department of Pediatrics Newborn Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Physiol 538:263-9. 2002
    ..The spontaneous arousal responses occur periodically but with a high level of irregularity and the level of activity is affected by sleep state...
  60. ncbi Evidence that REM sleep is controlled by the activation of brain stem pedunculopontine tegmental kainate receptor
    Subimal Datta
    Sleep Research Laboratory, Program in Behavioral Neuroscience and Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurophysiol 87:1790-8. 2002
    ..which specific receptor(s) in the cholinergic cell compartment of the PPT are involved in glutamate-induced-REM sleep. To identify these glutamate-induced REM-sleep-generating receptor(s) in the PPT cholinergic cell compartment, ..
  61. ncbi Chronic insomnia is associated with nyctohemeral activation of the hypothalamic-pituitary-adrenal axis: clinical implications
    A N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 86:3787-94. 2001
    ..The therapeutic goal in insomnia should be to decrease the overall level of physiologic and emotional arousal, and not just to improve the nighttime sleep...
  62. ncbi Microinjection of glutamate into the pedunculopontine tegmentum induces REM sleep and wakefulness in the rat
    S Datta
    Sleep Research Laboratory, Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Physiol Regul Integr Comp Physiol 280:R752-9. 2001
    ..08 nmol) and 30-ng (0.16 nmol) doses of L-glutamate into the PPT increased the total amount of REM sleep. Both doses of L-glutamate increased REM sleep at the expense of slow-wave sleep (SWS) but not wakefulness...
  63. ncbi Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PD
    A Iranzo
    Neurology Service, ospital Clínic and Institut d Investigació Biomèdiques August Pi i Sunyer, Barcelona, Spain
    Neurology 65:247-52. 2005
    To compare the clinical and video-polysomnographic (VPSG) characteristics of idiopathic REM sleep behavior disorder (RBD) vs the RBD seen in multiple system atrophy (MSA) and Parkinson disease (PD).
  64. ncbi Increased REM sleep associated with melatonin deficiency after pinealectomy: a case study
    Laurence Kocher
    Explorations Fonctionnelles et Consultations Neurologiques, Centre Hospitalier Lyon Sud, Pierre Benite Cedex, France
    Chronobiol Int 23:889-901. 2006
    ..MSLT showed abnormal sleep latency and two REM sleep onsets...
  65. ncbi Gamma EEG dynamics in neocortex and hippocampus during human wakefulness and sleep
    Jose L Cantero
    Department of Neurosurgery, Children s Hospital, and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA
    Neuroimage 22:1271-80. 2004
    ..These findings demonstrate a functional link between different stages of conscious awareness and the level of coupling of gamma-band oscillations in the human brain...
  66. ncbi Electroencephalographic slowing heralds mild cognitive impairment in idiopathic REM sleep behavior disorder
    Alex Iranzo
    Neurology Service, Multidisciplinary Sleep Unit, Hospital Clinic de Barcelona, Institut D Investigació Biomèdiques August Pi i Sunyer, CIBERNED, Barcelona, Spain
    Sleep Med 11:534-9. 2010
    ..We hypothesized that those IRBD patients who later developed MCI had pronounced cortical EEG slowing at presentation...
  67. ncbi Neuropeptide interactions and REM sleep: a role for Urotensin II?
    Luis de Lecea
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 701 B Welch Road, Palo Alto, CA 94304, United States
    Peptides 29:845-51. 2008
    ..receptor can be detected in the spinal cord and in cholinergic nuclei in the brainstem known to be involved in REM sleep regulation...
  68. ncbi Prominent eye movements during NREM sleep and REM sleep behavior disorder associated with fluoxetine treatment of depression and obsessive-compulsive disorder
    C H Schenck
    Minnesota Regional Sleep Disorders Center, Minneapolis 55415
    Sleep 15:226-35. 1992
    ..In addition, a 31-year-old man with obsessive-compulsive disorder developed RBD soon after starting fluoxetine therapy, which persisted at PSG study 19 months after fluoxetine discontinuation...
  69. ncbi The effects of sleep deprivation in humans: topographical electroencephalogram changes in non-rapid eye movement (NREM) sleep versus REM sleep
    Cristina Marzano
    Department of Psychology, University of Rome Sapienza, Rome, Italy
    J Sleep Res 19:260-8. 2010
    ..5 to 11 Hz and decreases from 13 to 15 Hz. In REM sleep, REC versus BSL differences pointed to significant fronto-central increases in the 0...
  70. pmc Hypocretin-2 saporin lesions of the ventrolateral periaquaductal gray (vlPAG) increase REM sleep in hypocretin knockout mice
    Satvinder Kaur
    Veterans Affairs Boston Healthcare System, and Harvard Medical School, West Roxbury, MA, USA
    PLoS ONE 4:e6346. 2009
    ..It is still not known how HCRT regulates REM sleep or muscle tone since HCRT neurons are localized only in the lateral hypothalamus while REM sleep and muscle ..
  71. ncbi A two-state stochastic model of REM sleep architecture in the rat
    Gavin G Gregory
    Department of Mathematical Sciences, The University of Texas at El Paso, El Paso, Texas 79968, USA
    J Neurophysiol 88:2589-97. 2002
    ..of REM sleep durations X and inter-REM sleep waiting times Y experienced by a rat during a sleeping period...
  72. ncbi Effects of the 5-HT(7) receptor antagonist SB-269970 microinjected into the dorsal raphe nucleus on REM sleep in the rat
    Jaime M Monti
    Department of Pharmacology and Therapeutics, Clinics Hospital, 2833 602 Zudanez Street, Montevideo 11300, Uruguay
    Behav Brain Res 167:245-50. 2006
    ..The 5-HT(7) receptor antagonist (0.25-1.0 mM) induced a significant reduction of REM sleep and of the number of REM periods whereas REM sleep latency was augmented...
  73. ncbi Clonidine effects on all-night human sleep: opposite action of low- and medium-dose clonidine on human NREM-REM sleep proportion
    Shinichi Miyazaki
    Department of Neuropsychiatry, Tokyo Medical and Dental University, Tokyo, Japan
    Psychiatry Clin Neurosci 58:138-44. 2004
    ..However, previous studies of clonidine effects on REM sleep have produced controversial results and the effects of clonidine remain uncertain...
  74. pmc Central deficiency of corticotropin-releasing hormone receptor type 1 (CRH-R1) abolishes effects of CRH on NREM but not on REM sleep in mice
    Christoph P N Romanowski
    Max Planck Institute of Psychiatry, Munich, Germany
    Sleep 33:427-36. 2010
    ..Therefore, we investigated in CNS-specific CRH receptor type 1 deficient mice whether centrally administered CRH could induce its sleep-wake modulatory effects without peripheral induction of HPA activity...
  75. ncbi REM sleep and dreaming: towards a theory of protoconsciousness
    J Allan Hobson
    Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Rev Neurosci 10:803-13. 2009
    ..The theory advanced here emphasizes data that suggest that REM sleep may constitute a protoconscious state, providing a virtual reality model of the world that is of functional use ..
  76. pmc REM sleep behavior disorder: Updated review of the core features, the REM sleep behavior disorder-neurodegenerative disease association, evolving concepts, controversies, and future directions
    Bradley F Boeve
    Department of Neurology and Center for Sleep Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Ann N Y Acad Sci 1184:15-54. 2010
    ..parasomnia manifested by vivid, often frightening dreams associated with simple or complex motor behavior during REM sleep. The polysomnographic features of RBD include increased electromyographic tone +/- dream enactment behavior ..
  77. ncbi Behavioral state instability in orexin knock-out mice
    Takatoshi Mochizuki
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Neurosci 24:6291-300. 2004
    ..Instead, the fragmented behavior of orexin KO mice may be best described as behavioral state instability, with apparently low thresholds to transition between states...
  78. ncbi Effects of method, duration, and sleep stage on rebounds from sleep deprivation in the rat
    A Rechtschaffen
    University of Chicago Sleep Research Laboratory, Department of Psychiatry, University of Chicago, Ill, USA
    Sleep 22:11-31. 1999
    ..These rebounds usually have been accompanied by substantial rebounds of REM sleep. In contrast, chronic TSD (2 weeks or longer) by the disk-over-water (DOW) method has produced only huge, long-..
  79. ncbi Dreaming and REM sleep are controlled by different brain mechanisms
    M Solms
    Academic Department of Neurosurgery, St Bartholomew s and Royal London School of Medicine, Royal London Hospital, London E1 1BB, United Kingdom
    Behav Brain Sci 23:843-50; discussion 904-1121. 2000
    The paradigmatic assumption that REM sleep is the physiological equivalent of dreaming is in need of fundamental revision...
  80. ncbi The rat ponto-medullary network responsible for paradoxical sleep onset and maintenance: a combined microinjection and functional neuroanatomical study
    Romuald Boissard
    CNRS FRE 2469, Institut Fédératif des Neurosciences de Lyon IFR 19, Universite Claude Bernard Lyon I, 8 avenue Rockefeller, 69373 Lyon Cedex 08, France
    Eur J Neurosci 16:1959-73. 2002
    ..Furthermore, they suggest that GABAergic disinhibition and glutamate excitation of these neurons might also play a crucial role in the onset of PS...
  81. ncbi REM sleep-like atonia of hypoglossal (XII) motoneurons is caused by loss of noradrenergic and serotonergic inputs
    Victor B Fenik
    Department of Animal Biology, 209E VET, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, Pennsylvania 19104 6046, USA
    Am J Respir Crit Care Med 172:1322-30. 2005
    ..XII) motoneurons that innervate the genioglossus muscle, an upper airway dilator, suggested that the suppression of upper airway motor tone during REM sleep is caused by withdrawal of excitation mediated by norepinephrine and serotonin.
  82. ncbi Temporal coupling of parahippocampal ripples, sleep spindles and slow oscillations in humans
    Zsófia Clemens
    Department of Neurology, National Institute of Psychiatry and Neurology, Budapest, Hungary
    Brain 130:2868-78. 2007
    Ripples are high-frequency oscillation bursts in the mammalian hippocampus mainly present during Non-REM sleep. In rodents they occur in association with sharp waves and are grouped by the cortical slow oscillation such that, in parallel ..
  83. ncbi Functional microstates within human REM sleep: first evidence from fMRI of a thalamocortical network specific for phasic REM periods
    Renate Wehrle
    Max Planck Institute of Psychiatry, Kraepelinstr 10, D 80804 Munich, Germany
    Eur J Neurosci 25:863-71. 2007
    ..REM) sleep, but apparently this network fulfills other roles than processing external information during REM sleep. To investigate thalamic and cortical reactivity during human REM sleep, we used functional magnetic resonance ..
  84. ncbi Noradrenergic neurons expressing Fos during waking and paradoxical sleep deprivation in the rat
    Lucienne Leger
    Universite de Lyon, Lyon, France
    J Chem Neuroanat 37:149-57. 2009
    ..They further suggest that the inhibitory effect of noradrenaline on PS may be due to the A1/C1, A2 and to a lesser degree to A5 neurons but not from those of the LC as previously hypothesized...
  85. pmc Sleep-waking discharge patterns of neurons recorded in the rat perifornical lateral hypothalamic area
    Md Noor Alam
    Research Service, V A Greater Los Angeles Healthcare System, North Hills, CA 91343, USA
    J Physiol 538:619-31. 2002
    ..discharge rates were calculated during active waking (waking accompanied by movement), quiet waking, non-REM sleep and REM sleep. Fifty-six of 106 neurons (53 %) were classified as wake/REM-related...
  86. ncbi Increased EEG spectral power density during sleep following short-term sleep deprivation in pigeons (Columba livia): evidence for avian sleep homeostasis
    Dolores Martinez-Gonzalez
    Max Planck Institute for Ornithology, Seewiesen, Germany
    J Sleep Res 17:140-53. 2008
    ..SWA was also elevated during REM sleep on the recovery night, a response that might reflect increased SWS pressure and the concomitant 'spill-over' of ..
  87. ncbi Autonomic function in sleep apnea patients: increased heart rate variability except during REM sleep in obese patients
    Erica B Reynolds
    Eastern Virginia Medical School, Sentara Norfolk General Hospital, Norfolk, USA
    Sleep Breath 11:53-60. 2007
    ..We sampled the electrocardiogram (ECG) from wakefulness, stage 2, and REM sleep and analyzed for frequency domain HRV. Sampled epochs were free of apnea and arousals...
  88. ncbi The Munich vulnerability study on affective disorders: premorbid polysomnographic profile of affected high-risk probands
    Sieglinde Modell
    Max Planck Institute of Psychiatry, Munich
    Biol Psychiatry 58:694-9. 2005
    ..To identify vulnerability markers, we investigated premorbid sleep EEG parameters in healthy high-risk probands (HRPs) with a positive family history of affective disorders...
  89. ncbi Sleep-dependent learning: a nap is as good as a night
    Sara Mednick
    Psychology Department, Harvard University, 33 Kirkland Street, Cambridge, Massachusetts 02138, USA
    Nat Neurosci 6:697-8. 2003
    ..Thus, from the perspective of behavioral improvement, a nap is as good as a night of sleep for learning on this perceptual task...
  90. pmc A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep
    Laure Verret
    CNRS UMR5167, Institut Fédératif des Neurosciences de Lyon IFR 19, Universite Claude Bernard Lyon I, 7 rue Guillaume Paradin, 69372 Lyon Cedex 08, France
    BMC Neurosci 4:19. 2003
    ..determine whether hypocretin and MCH neurons express Fos in association with enhanced paradoxical sleep (PS or REM sleep) during the rebound following PS deprivation...
  91. ncbi Relationships between REM sleep findings and PTSD symptoms during the early aftermath of trauma
    Thomas A Mellman
    Department of Psychiatry, Howard University, Washington, DC 20059, USA
    J Trauma Stress 20:893-901. 2007
    ..Relative beta frequency during REM sleep from a subset of cases correlated negatively with PTSD and nightmare severity...
  92. pmc Localization of the brainstem GABAergic neurons controlling paradoxical (REM) sleep
    Emilie Sapin
    CNRS, UMR5167, Physiopathologie des réseaux neuronaux du cycle veille sommeil, Lyon, France
    PLoS ONE 4:e4272. 2009
    ..From these results, we propose a revised model for PS control in which GABAergic PS-on and PS-off neurons localized in the vlPAG/dDPMe region play leading roles...
  93. ncbi Localization of the neurons active during paradoxical (REM) sleep and projecting to the locus coeruleus noradrenergic neurons in the rat
    Laure Verret
    Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5167, Institut Fédératif des Neurosciences de Lyon IFR19, Lyon F 69372, France
    J Comp Neurol 495:573-86. 2006
    ..Although all these populations of CTb/Fos double-labeled neurons could be GABAergic and tonically inhibit LC neurons during PS, our results indicate that neurons from the DPGi constitute the best candidate for this role...
  94. ncbi Age-related changes in slow wave sleep and REM sleep and relationship with growth hormone and cortisol levels in healthy men
    E Van Cauter
    Department of Medicine, MC 1027, University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    JAMA 284:861-8. 2000
    ..In young adults, sleep affects the regulation of growth hormone (GH) and cortisol. The relationship between decreased sleep quality in older adults and age-related changes in the regulation of GH and cortisol is unknown...
  95. ncbi Scoring transitions to REM sleep in rats based on the EEG phenomena of pre-REM sleep: an improved analysis of sleep structure
    J H Benington
    Department of Biological Sciences, Stanford University, California
    Sleep 17:28-36. 1994
    Algorithms for scoring sleep/waking states and transitions to REM sleep (NRTs) in rats are presented and validated. Both algorithms are based on electroencephalographic (EEG) power in delta (0.5-4...
  96. ncbi REM sleep behavior disorder and REM sleep without atonia in probable Alzheimer disease
    Jean Francois Gagnon
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, Qudbec, Canada
    Sleep 29:1321-5. 2006
    To determine the frequency of rapid eye movement (REM) sleep behavior disorder (RBD) and REM sleep without atonia among patients with Alzheimer disease and control subjects.
  97. ncbi Dementia with Lewy bodies may present as dementia and REM sleep behavior disorder without parkinsonism or hallucinations
    Tanis J Ferman
    Department of Psychiatry and Psychology, Mayo Clinic and Foundation, Jacksonville, Florida 32224, USA
    J Int Neuropsychol Soc 8:907-14. 2002
    ..This provides further evidence in support of including RBD as one of the core diagnostic features of DLB...
  98. ncbi Differential localization of carbachol- and bicuculline-sensitive pontine sites for eliciting REM sleep-like effects in anesthetized rats
    Victor B Fenik
    Department of Animal Biology, School of Veterinary Medicine, Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, PA 19104 6046, USA
    J Sleep Res 18:99-112. 2009
    ..In urethane-anesthetized rats, in which carbachol effectively elicits REM sleep-like episodes (REMSLE), we tested the ability of 10 nL microinjections of carbachol (10 mm) and bicuculline (0...
  99. ncbi Donepezil-induced REM sleep augmentation enhances memory performance in elderly, healthy persons
    M Schredl
    Sleep Laboratory, Central Institute of Mental Health, P O Box 122120, 68072, Mannheim, Germany
    Exp Gerontol 36:353-61. 2001
    Previous research in younger individuals has shown that acetylcholinesterase inhibitors may enhance REM sleep. The present study indicates that in the elderly, donepezil, an acetylcholinesterase inhibitor, also exerts a marked effect on ..
  100. ncbi A5 cells are silenced when REM sleep-like signs are elicited by pontine carbachol
    Victor Fenik
    Department of Animal Biology, School of Veterinary Medicine, and Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6046, USA
    J Appl Physiol (1985) 93:1448-56. 2002
    ..paralyzed, and artificially ventilated rat in which pontine microinjections of carbachol trigger signs of REM sleep, including hippocampal theta rhythm, motor suppression, and silencing of locus coeruleus neurons...
  101. ncbi REM sleep deprivation in monocularly occluded kittens reduces the size of cells in LGN monocular segment
    J P Shaffery
    Dept. of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson 39216-4505, USA
    Sleep 21:837-45. 1998
    ..Our findings in the MS of the LGN indicate that during the usual operation of REM sleep, central visual-sensory sites receive intrinsic activation that, in the visual system, is additive and ..

Research Grants70

  1. Cardiovascular Responses to Sleep Apnea in Tetraplegia: A Pilot Study
    Jill M Wecht; Fiscal Year: 2010
    ..predispose to greater apnea severity and potentiate falls in cardiac output similar to that observed during REM sleep in able-bodied persons, but will likely occur regardless of sleep stage...
  2. ECG-derived cardiopulmonary coupling biomarkers of sleep, sleep-breathing, and ca
    Robert J Thomas; Fiscal Year: 2010
    ..coupling (LFC) is unstable or physiologically aroused sleep, and very low frequency coupling (VLFC) is wake or REM sleep. Health is dominated by HFC, diseases such as sleep apnea by LFC...
  3. The upper airway and the Sudden Infant Death Syndrome
    Donald Bartlett; Fiscal Year: 2012
    ..We will also study intact, chronically instrumented piglets during wakefulness, NREM and REM sleep to determine the combined influence on the LCR of hyperthermia and manipulation of central nervous system ..
  4. CHOLINERGIC MECHANISMS OF REM SLEEP GENERATION
    Helen A Baghdoyan; Fiscal Year: 2013
    ..Acetylcholine (ACh) plays a key role in generating the rapid eye movement (REM) phase of sleep, and REM sleep abnormalities typify some forms of depression...
  5. Basal Forebrain Cellular Mechanisms of Cortical Activation
    Robert W McCarley; Fiscal Year: 2013
    ..Hz or broader, centered on 40 Hz) are a prominent feature of the electroencephalogram (EEG) during waking and REM sleep. These oscillations are thought to be essential for brain functions such as attention, perception, and memory ..
  6. Adult Neurogenesis: Regulation By Sleep
    DENNIS J MCGINTY; Fiscal Year: 2013
    ..Hippocampal DG GABAergic neurons are activated during sleep. By manipulating NREM and REM sleep, we will determine what properties and stages of sleep are maximally associated with GABAergic neuronal ..
  7. Functional Anatomy of REM Sleep: Brainstem-Control
    Gerald A Marks; Fiscal Year: 2013
    ..The proposed project addresses the neural mechanisms that control and modulate the expression of REM sleep. Evidence supports REM sleep to be dependent on a set of anatomically distributed neural mechanisms...
  8. Unihemispheric sleep: implications for mechanisms of sleep control and function i
    Jerome M Siegel; Fiscal Year: 2013
    ..mammals when they are on land, but when the are in water they have unihemispheric nonREM sleep and little or no REM sleep for very long periods of time...
  9. Sleep Disruption and Mild Cognitive Impairment in Veterans
    CYNTHIA HOLDEN PHELAN; Fiscal Year: 2013
    ..Sleep slow waves, an electrophysiological characteristic of non-REM sleep, are considered a reliable marker for sleep homeostasis and have been linked to the beneficial effects of sleep ..
  10. Neurobiological studies of gammahydroxybutyrate
    Thomas S Kilduff; Fiscal Year: 2012
    ..We will exploit a mouse model of narcolepsy in which the Hcrt neurons degenerate postnatally as they do in human narcoleptics to understand how GHB is beneficial in human narcolepsy. ..
  11. The Role Leptin on Arousal
    PAIGE B BECK; Fiscal Year: 2013
    ..provided by applicant): Dysregulation of sleep/wake control can result in life-long disturbances in arousal and REM sleep drive, leading to hypervigilance or hypovigilance such as that observed in a number of neuropsychiatric ..
  12. Quantification of the State-Dependent Inputs to Hypoglossal Motoneurons
    VICTOR BORISOVICH FENIK; Fiscal Year: 2010
    ..of research, there is no consensus about the mechanisms of the depression of this motoneuronal pool during REM sleep. In order to understand the responsible mechanisms, we will use intracellular recording during natural sleep and ..
  13. PREMOTOR CONTROL OF UPPER AIRWAY AND REM SLEEP ATONIA
    LESZEK K KUBIN; Fiscal Year: 2012
    ..from A1 XII-premotor cells to determine whether their activity is altered during pharmacologically induced REM sleep-like state...
  14. Neurobiological Mechanisms of Sympathetic Regulation in Sleep Apnea
    Anne M Fink; Fiscal Year: 2013
    ..SMR) that significantly and differentially regulates sympathetic activities across sleep-wake states (such as REM sleep) and that altered PPT-SMR function in OSA represents a mechanistic link between OSA and aberrant activation of ..
  15. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David W Carley; Fiscal Year: 2013
    ..The neuronal networks and synaptic mechanisms that render autonomic outputs more labile during REM sleep remain poorly defined, but during the previous funding cycle we developed key evidence supporting a respiratory ..
  16. REM mechanisms in neocortical development
    Marcos G Frank; Fiscal Year: 2013
    ..Ca2+/calmodulin- dependent protein kinase [CaMKII] and extracellular regulated kinase [ERK]) activated in REM sleep. We propose the following Specific Aims: 1...
  17. Sleep and the Generalization Extinction of Conditioned Fear
    Edward F Pace-Schott; Fiscal Year: 2012
    ..phasic events in sleep that have been associated with memory phenomena including rapid-eye-movement density in REM sleep and sleep spindle density in Stage 2 non-REM sleep, and examine their association with extinction generalization...
  18. Limbic modulation of stress-induced alterations in sleep
    Larry D Sanford; Fiscal Year: 2013
    ..with uncontrollable stress produces overt fear behavior in wakefulness (freezing in rodents) and decreases REM sleep whereas fear learning associated with controllable stress produces similar fear behavior in wakefulness but can ..
  19. Sleep, proprioception, and forebrain activity in infant mutant mice
    MARK SAMUEL BLUMBERG; Fiscal Year: 2013
    ....
  20. Genetic Approaches to Sleep/Wake and Response to Sleep Loss in Mice
    ALLAN IAN PACK; Fiscal Year: 2013
    ..Future studies will also extend this investigation into human populations using samples of well characterized individuals who have been studied with sleep loss and whose DNA is already available. ..
  21. Developing Novel Methods to Elucidate Mechanisms of Pediatric Sleep Apnea
    Brian M McGinley; Fiscal Year: 2013
    ..These measurements, however, are laborious, and not well tolerated by young children or during REM sleep. Polysomnography is well tolerated by children, however, conventional measures of sleep apnea severity (AHI, ..
  22. Modulation of REM sleep circuitry and involvement of hypocretin in female rats
    Danielle Cusmano; Fiscal Year: 2013
    ..The LH contains hypocretin, a neuropeptide intimately involved in arousal as well as inhibition of REM sleep. Thus, our overarching hypothesis is that E2 suppresses activation of MnPN neurons to initiate downstream ..
  23. Pontine Control of REM Atonia
    Elda Arrigoni; Fiscal Year: 2013
    PROJECT SUMMARY/ABSTRACT A defining feature of REM sleep is paralysis of nearly all muscles. In REM sleep behavior disorder (RBD), the absence of REM atonia permits the appearance of dream enactment...
  24. Interdependence among neuromodulators of ventilatory control
    Hubert V Forster; Fiscal Year: 2013
    ..dialysis of a [unreadable]- opioid agonist within the HMN will decrease I and GG activity which during NREM and REM sleep will lead to SDB, b) there will be no compensatory changes in any of the measured local neurochemicals in the ..
  25. Cellular and Molecular Mechanisms of REM Sleep
    Subimal Datta; Fiscal Year: 2013
    ..of this research is to further our understanding of brainstem cellular, molecular, and network mechanisms of REM sleep regulation...
  26. Neural consequences of sleep loss and sleep physiology on the human reward system
    STEPHANIE MORGAN GREER; Fiscal Year: 2013
    ..additionally (ii) biases the brain towards disproportionately reward-driven hippocampal learning, and (iii) REM sleep quantity and spectral quality during normal sleep is predictive of these neural and behavioral reward processes...
  27. Hippocampal Network Dynamics during Sleep
    Athanassios G Siapas; Fiscal Year: 2012
    ..experience-specific traces of parametrically varying strengths and measure their evolution over several SWS/REM sleep stages...
  28. Neural pathway of REM sleep atonia
    Jun Lu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Loss of atonia is a cardinal sign of REM sleep behavior disorder (RBD) that precedes many neural degenerative diseases such as Parkinson's disease and Alzheimer's disease by a decade...
  29. A non-invasive high-throughput sleep stage analysis system
    David A Johnson; Fiscal Year: 2012
    ..this system aims to be the first commercial device designed to record and automatically analyze wake, NREM and REM sleep in rodents using non-surgical, non-invasive techniques...
  30. Noradrenergic A7 neurons and Upper Airway Motor Control
    VICTOR BORISOVICH FENIK; Fiscal Year: 2013
    ..contribution to the mechanisms of the depression of hypoglossal motoneurons excitability during non-REM and REM sleep. Obtained information will advance our understanding of the neuronal network and neurochemical mechanisms that ..
  31. Development and Testing of a Device for Enhancing Memory During Sleep
    Alexander F Butterwick; Fiscal Year: 2012
    ..Slow-wave ('deep') sleep is a form of non-REM sleep during which patterns of brain activity that occurred during recent episodes of learning are re-played and ..
  32. TAAR1 and the Control of Wakefulness
    Thomas S Kilduff; Fiscal Year: 2013
    ..also show that TAAR1 partial agonism causes a dose- dependent increase in wakefulness and decreases in NREM and REM sleep, indicating that this receptor activates an endogenous wake-promoting system...
  33. Effects of an angiotensin ll antagonist in a rat model of insomnia
    Georgina Cano; Fiscal Year: 2013
    ..In addition, current treatments decrease REM sleep substantially and do not restore normal sleep...
  34. Central Modulation of Rhythms
    Edgar E Garcia-Rill; Fiscal Year: 2012
    ..From 10-30 days postnatally there is a dramatic decrease in the percent of REM sleep in the rat...
  35. The Control of Active (REM) Sleep by the Amygdala
    Michael H Chase; Fiscal Year: 2012
    ....
  36. Neuropathology of Hypocretin
    Jerome M Siegel; Fiscal Year: 2013
    ..For example, narcoleptics have disrupted nighttime sleep and an increased incidence of REM sleep behavior disorder, symptoms that appear to be opposite to the sleepiness and cataplexy that are the best known ..
  37. TAAR1 Agonists as Narcolepsy Therapeutics
    Thomas S Kilduff; Fiscal Year: 2013
    ..These compounds cause a dose-dependent increase in wakefulness, reduce REM sleep, and have pro- cognitive, antidepressant- and antipsychotic-like properties, suggesting TAAR1 as a novel target ..
  38. STATE DEPENDENT ASPECTS OF COGNITION
    Robert Stickgold; Fiscal Year: 2013
    ..of particular classes of memory to discrete sleep stages, for example consolidation of procedural memories to REM sleep or declarative memories to slow wave sleep (SWS)...
  39. Repeated Partial Sleep Deprivation to Augment SSRI Response in Depression
    J Todd Arnedt; Fiscal Year: 2012
    ..Our data further suggest that non-responders to fluoxetine treatment have shorter REM latency and more REM sleep than non-responders, particularly in the last few hours of the night...
  40. Sleep Neurobiology and Circuitry
    Priyattam J Shiromani; Fiscal Year: 2013
    ..but researchers have now determined that a distributed network of neurons are responsible for wake, non-REM and REM sleep. First-order circuit models have emerged, and these have been tested using traditional lesion and gene deletion ..
  41. Behavioral state development in infants
    MARK SAMUEL BLUMBERG; Fiscal Year: 2013
    ..Moreover, the approach that informs this work is contributing to a fundamental reconceptualization of infant sleep that will soon provide the foundation for a broader understanding of the function of sleep in both infants and adults. ..
  42. HYPOTHALAMIC REGULATION OF SLEEP
    Priyattam J Shiromani; Fiscal Year: 2013
    ..or complete reversal? Is the effect site specific? Are the neurons connected to pontine sites implicated in REM sleep? Experiments with appropriate controls are proposed to strengthen the conclusions...
  43. Neurobiology of PTSD During REM Sleep
    Anne Germain; Fiscal Year: 2010
    ..These observations suggest that daytime PTSD symptoms may be partially mediated by REM sleep-specific mechanisms, and that these REM sleep-specific mechanisms are not normalized by recommended first-line ..
  44. REM SLEEP AND MEMORY
    Gina R Poe; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): We hypothesize that the absence of NE in the forebrain during REM sleep and the spindle-rich transition to REM sleep (TR) allows for synaptic depotentiation underlying normal assimilation of new ..
  45. Dynamic Cortical Network Estimation from TMS/EEG
    Barry D Van Veen; Fiscal Year: 2013
    ..LDPM) for TMS/EEG;and 2) Quantify LDPM network properties in humans during three vigilance states: wake, non-REM sleep, and anesthesia...
  46. A Rodent Model of TBI Suffered During Sustained Combat Operations
    RONALD RIECHERS; Fiscal Year: 2009
    ..The groups will be randomized to one of the following conditions for 24 hours prior to surgery: REM sleep deprived, social isolation, normal rat laboratory environment...
  47. Sleep Adaptations to Stress
    Thomas A Mellman; Fiscal Year: 2013
    ..Insights from this study will inform individual and public healt approaches to ameliorating health disparities attributable to compromised sleep. ..
  48. Circadian and Aminergic Regulation of Orexin Neurons
    THOMAS SCAMMELL; Fiscal Year: 2005
    ..People with narcolepsy have difficulty maintaining wakefulness and often have intrusions of REM sleep-like phenomena into wakefulness...
  49. OREXIN AND THE CONTROL OF SLEEP AND WAKEFULNESS
    ROBERT MC CARLEY; Fiscal Year: 2005
    ..narcolepsy and mouse knock-out experiments link to cataplexy/narcolepsy, which may be regarded as disorders of REM sleep and wakefulness...
  50. Cellular and Molecular Mechanisms of REM Sleep Control
    James Quattrochi; Fiscal Year: 2005
    ..preliminary studies have led to two important discoveries: 1) cholinergically induced long-term enhancement of REM sleep (LTRE): and 2) long-term enhancement of ponto-geniculo-occipital (PGO) waves (LTPE) that are a distinguishing ..
  51. ELECTROPHYSIOLOGY & PHARMACOLOGY OF SLEEP-WAKEFULNESS
    Mahesh Thakkar; Fiscal Year: 2004
    ..The REM sleep phase...
  52. Orexins in Rapid Eye Movement Sleep Control.
    Mahesh Thakkar; Fiscal Year: 2009
    ..There is considerable evidence linking orexins to cataplexy/narcolepsy, which may be regarded as REM sleep disorders...
  53. Ventral Mesopontine Junction and Motor Activity
    Yuan Yang Lai; Fiscal Year: 2006
    ..nucleus and ventral tegmental area, plays a crucial role in the etiology of this disorder, as well as in REM sleep behavior disorder (RBD), which is present in 0.5 percent of the population...
  54. Amygdalar Modulation of Fear-Conditioned Changes in REM Sleep
    ADRIAN MORRISON; Fiscal Year: 2009
    ..Specifically, we shall study changes in REM sleep (REM) after fear conditioning in rats, and related behavioral changes during wakefulness (W)...
  55. Control of Muscle Tone in nonREM Sleep
    Jerome Siegel; Fiscal Year: 2009
    ..Nocturnal bruxism produces severe dental problems. Sleep apnea occurs in both nonREM and REM sleep. Sleepwalking, PLMS and nocturnal bruxism occur predominantly in nonREM sleep...
  56. Sleep in Cetaceans
    Jerome Siegel; Fiscal Year: 2006
    ..Another unusual feature of cetacean sleep is the apparent absence or perhaps the near absence of REM sleep. If cetaceans do not have REM sleep, they would be the only mammals lacking this state...
  57. CHOLINERGIC MECHANISMS OF REM SLEEP GENERATION
    HELEN BAGHDOYAN; Fiscal Year: 1993
    ..proposal are to characterize the specific muscarinic and nicotinic cholinergic receptor mechanisms that generate REM sleep. This proposal further aims to extend the foregoing cholinergic hypothesis by examining the role of central ..
  58. CELLULAR BASIS OF BRAINSTEM PGO WAVE GENERATION
    Subimal Datta; Fiscal Year: 2000
    DESCRIPTION: (Applicant's Abstract) This application's long-term objective is to understand the mechanisms of REM sleep and dPBO wave generation...
  59. AN INDISPENSABLE RESOURCE FOR THE STUDY OF NARCOLEPSY
    William Dement; Fiscal Year: 1993
    The goal of the Center for Narcolepsy research is to unravel the cause of narcolepsy, a genetic disorder of REM sleep affecting approximately 250,000 Americans...
  60. COMPARATIVE PHYSIOLOGY OF SLEEP
    Jerome Siegel; Fiscal Year: 1999
    ..these investigators have found that the platypus and echidna, primitive mammals previously thought to lack REM sleep, have REM sleep in very large amounts...
  61. REM SLEEP DEPRIVATION, HYPOXIA, AND HIPPOCAMPAL FUNCTION
    David Gozal; Fiscal Year: 2003
    ..and is characterized by repeated episodes of hypoxia and recurrent EEG/behavioral arousal, particularly during REM sleep. When untreated, OSAS is associated with significant neurocognitive morbidities such as excessive daytime ..
  62. NEUROCOGNITIVE ANALYSIS OF REM SLEEP AND DREAMING
    J Hobson; Fiscal Year: 2000
    ..The main goal of the research program described in this proposal is to study REM sleep so as to account, in detailed cellular and molecular terms for the distinctive formal features of dreaming...
  63. BRAINSTEM CHOLINERGIC NEUROANATOMY AND NEUROPHYSIOLOGY
    Priyattam Shiromani; Fiscal Year: 1991
    ..The disease appears to be a disorder of REM sleep because some narcoleptic symptoms are components of REM sleep which are somehow encroaching into the waking ..
  64. ACUTE EFFECTS OF LIGHT ON SLEEP
    Ruth Benca; Fiscal Year: 2003
    ..in their rapid eye-movement (REM) sleep patterns; following lights-off, they exhibit large increases in REM sleep (REM sleep triggering), whereas lights-on suppresses REM sleep...
  65. Human Sleep Neuroscience
    Eric Nofzinger; Fiscal Year: 2009
    ..In depression, a ventral limbic and paralimbic system is abnormally overactive in REM sleep and a dorsal executive system including the prefrontal cortex is abnormal in NREM sleep...
  66. NEUROPHYSIOLOGICAL MECHANISMS OF SLEEP CYCLE CONTROL
    J Hobson; Fiscal Year: 1991
    b>REM sleep is a behavioral state of all mammalian organisms, including humans, which is controlled by active neuronal mechanisms in the pontine brain stem...
  67. NEUROPHYSIOLOGICAL MECHANISMS OF SLEEP CYCLE CONTROL
    J Hobson; Fiscal Year: 2001
    ..pharmacology techniques, considerable progress in delineating the triggering neuronal circuitry of REM sleep has been made but its long term regulation and functional consequences remain obscure...
  68. Wake/Sleep Development and Depressive Substrates
    Pingfu Feng; Fiscal Year: 2006
    ..Extensive literature, including our previous studies, supports our hypothesis that neonatal REM sleep deprivation (RSD) alters the balance of development of wake promoting consequences and creates a disinhibited ..
  69. PET STUDIES OF SLEEP IN AFFECTIVE DISORDERS
    Monte Buchsbaum; Fiscal Year: 1990
    ..FDG) will be used to study regional brain metabolic patterns during rapid eye movement (REM) sleep and non-REM sleep in 40 patients with affective disorder and age and sex-matched controls...
  70. CHRONOENDOCRINOLOGY OF SLEEP DISTURBANCES IN DEPRESSION
    RUSSELL POLAND; Fiscal Year: 1990
    ..biologically and immunologically active plasma adrenocorticotropin (ACTH) and cortisol will be correlated with REM sleep measures...