sleep stages

Summary

Summary: Periods of sleep manifested by changes in EEG activity and certain behavioral correlates; includes Stage 1: sleep onset, drowsy sleep; Stage 2: light sleep; Stages 3 and 4: delta sleep, light sleep, deep sleep, telencephalic sleep.

Top Publications

  1. ncbi Natural waking and sleep states: a view from inside neocortical neurons
    M Steriade
    Laboratoire de Neurophysiologie, Faculte de Medicine, Universite Laval, Quebec G1K 7P4, Canada
    J Neurophysiol 85:1969-85. 2001
  2. ncbi Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan
    Maurice M Ohayon
    Stanford Sleep Epidemiology Research Center, School of Medicine, Stanford University, Palo Alto, CA 94303, USA
    Sleep 27:1255-73. 2004
  3. ncbi The visual scoring of sleep in adults
    Michael H Silber
    Mayo Sleep Disorders Center, Mayo Clinic College of Medicine, Rochester, MN 55902, USA
    J Clin Sleep Med 3:121-31. 2007
  4. ncbi The role of sleep in learning and memory
    P Maquet
    Wellcome Department of Cognitive Neurology, University College London, London WC1N 3BG, UK
    Science 294:1048-52. 2001
  5. ncbi Learning-dependent increases in sleep spindle density
    Steffen Gais
    Department of Neuroendocrinology, University of Lubeck, 23564 Lübeck, Germany
    J Neurosci 22:6830-4. 2002
  6. pmc The human K-complex represents an isolated cortical down-state
    Sydney S Cash
    Department of Neurology, Epilepsy Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Science 324:1084-7. 2009
  7. ncbi Frontal predominance of a relative increase in sleep delta and theta EEG activity after sleep loss in humans
    C Cajochen
    Circadian, Neuroendocrine and Sleep Disorders Section, Division of Endocrinology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Sleep Res Online 2:65-9. 1999
  8. ncbi The homeostatic regulation of sleep need is under genetic control
    P Franken
    Biochemistry and Neurophysiology Unit, Department of Psychiatry, University of Geneva, Chene Bourg, Switzerland
    J Neurosci 21:2610-21. 2001
  9. ncbi Driver drowsiness classification using fuzzy wavelet-packet-based feature-extraction algorithm
    Rami N Khushaba
    ARC Centre of Excellence for Autonomous Systems, Faculty of Engineering and Information Technology, University of Technology, Sydney, Broadway NSW 2007, Australia
    IEEE Trans Biomed Eng 58:121-31. 2011
  10. ncbi Age-related changes in the circadian and homeostatic regulation of human sleep
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinics, Basel, Switzerland
    Chronobiol Int 23:461-74. 2006

Research Grants

Detail Information

Publications291 found, 100 shown here

  1. ncbi Natural waking and sleep states: a view from inside neocortical neurons
    M Steriade
    Laboratoire de Neurophysiologie, Faculte de Medicine, Universite Laval, Quebec G1K 7P4, Canada
    J Neurophysiol 85:1969-85. 2001
    ..In view of the high firing rates in the functionally disconnected state of slow-wave sleep, we suggest that neocortical neurons are engaged in processing internally generated signals...
  2. ncbi Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan
    Maurice M Ohayon
    Stanford Sleep Epidemiology Research Center, School of Medicine, Stanford University, Palo Alto, CA 94303, USA
    Sleep 27:1255-73. 2004
    ....
  3. ncbi The visual scoring of sleep in adults
    Michael H Silber
    Mayo Sleep Disorders Center, Mayo Clinic College of Medicine, Rochester, MN 55902, USA
    J Clin Sleep Med 3:121-31. 2007
    ..Advances in the ensuing 28 years warranted a re-look at visual scoring of sleep stages. This paper describes the work of the AASM Visual Scoring Task Force, including methodology, a literature ..
  4. ncbi The role of sleep in learning and memory
    P Maquet
    Wellcome Department of Cognitive Neurology, University College London, London WC1N 3BG, UK
    Science 294:1048-52. 2001
    ..The underlying role of sleep in learning and memory has yet to be precisely characterized...
  5. ncbi Learning-dependent increases in sleep spindle density
    Steffen Gais
    Department of Neuroendocrinology, University of Lubeck, 23564 Lübeck, Germany
    J Neurosci 22:6830-4. 2002
    ..56; p < 0.05). Power spectra and time spent in sleep stages did not differ between learning and nonlearning conditions...
  6. pmc The human K-complex represents an isolated cortical down-state
    Sydney S Cash
    Department of Neurology, Epilepsy Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Science 324:1084-7. 2009
    ..This correspondence is compatible with proposed contributions of the KC to sleep preservation and memory consolidation...
  7. ncbi Frontal predominance of a relative increase in sleep delta and theta EEG activity after sleep loss in humans
    C Cajochen
    Circadian, Neuroendocrine and Sleep Disorders Section, Division of Endocrinology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Sleep Res Online 2:65-9. 1999
    ..The data demonstrate that the enhancement of slow wave EEG activity during sleep following extended wakefulness is most pronounced in frontal cortical areas...
  8. ncbi The homeostatic regulation of sleep need is under genetic control
    P Franken
    Biochemistry and Neurophysiology Unit, Department of Psychiatry, University of Geneva, Chene Bourg, Switzerland
    J Neurosci 21:2610-21. 2001
    ..These results demonstrate, for the first time, that the increase of SWS need is under a strong genetic control, and they provide a basis for identifying genes underlying SWS homeostasis...
  9. ncbi Driver drowsiness classification using fuzzy wavelet-packet-based feature-extraction algorithm
    Rami N Khushaba
    ARC Centre of Excellence for Autonomous Systems, Faculty of Engineering and Information Technology, University of Technology, Sydney, Broadway NSW 2007, Australia
    IEEE Trans Biomed Eng 58:121-31. 2011
    ..The experimental results proved the significance of FMIWPT in extracting features that highly correlate with the different drowsiness levels achieving a classification accuracy of 95%-- 97% on an average across all subjects...
  10. ncbi Age-related changes in the circadian and homeostatic regulation of human sleep
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinics, Basel, Switzerland
    Chronobiol Int 23:461-74. 2006
    ..Our data suggest that manipulations of the circadian timing system, rather than the sleep homeostat, may offer a potential strategy to alleviate age-related decrements in sleep and daytime alertness levels...
  11. ncbi Neurobiology of REM and NREM sleep
    Robert W McCarley
    Neuroscience Laboratory, VA Boston Healthcare System, 940 Belmont St, Brockton, MA 02301, USA
    Sleep Med 8:302-30. 2007
    ..Finally, the results of a new series of experimental paradigms in rodents to measure the neurocognitive effects of sleep loss and sleep interruption (modeling sleep apnea) provide animal model data congruent with those in humans...
  12. pmc Declarative memory consolidation: mechanisms acting during human sleep
    Steffen Gais
    Department of Neuroendocrinology, University of Lubeck, Lubeck 23538, Germany
    Learn Mem 11:679-85. 2004
    ..In addition, sleep seems to provide an optimal milieu for declarative memory reprocessing and consolidation by reducing cholinergic activation and the cortisol feedback to the hippocampus during SWS...
  13. ncbi Large-amplitude, spatially correlated fluctuations in BOLD fMRI signals during extended rest and early sleep stages
    Masaki Fukunaga
    Advanced MRI, LFMI, NINDS, National Institutes of Health, Bethesda, MD 20892 1065, USA
    Magn Reson Imaging 24:979-92. 2006
    ..These findings suggest that resting-state activity continues during sleep and does not require active cognitive processes or conscious awareness...
  14. ncbi Circadian temperature and melatonin rhythms, sleep, and neurobehavioral function in humans living on a 20-h day
    J K Wyatt
    Circadian, Neuroendocrine and Sleep Disorders Section, Division of Endocrinology, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol 277:R1152-63. 1999
    ..The data demonstrate the exquisite sensitivity of many neurobehavioral functions to circadian phase and the accumulation of homeostatic drive for sleep...
  15. pmc Topography-specific spindle frequency changes in obstructive sleep apnea
    Suzana V Schönwald
    Sleep Laboratory, Division of Pulmonary Medicine, Hospital de Clinicas de Porto Alegre, Rua Ramiro Barcelos 2350 sala 2050, Porto Alegre, RS, 90035 003, Brazil
    BMC Neurosci 13:89. 2012
    ....
  16. pmc Rethinking sleep analysis
    Hartmut Schulz
    J Clin Sleep Med 4:99-103. 2008
    ..Limitations of sleep staging are critically discussed and alternative strategies of sleep analysis are emphasized...
  17. ncbi Objective measure of sleepiness and sleep latency via bispectrum analysis of EEG
    Vinayak Swarnkar
    The University of Queensland, Brisbane, Australia
    Med Biol Eng Comput 48:1203-13. 2010
    ..It can also be developed into a sleep management system, wherein the SI is incorporated into a sleepiness index alert unit to alarm the user when sleepiness level crosses the predetermined threshold...
  18. ncbi Human non-rapid eye movement stage II sleep spindles are blocked upon spontaneous K-complex coincidence and resume as higher frequency spindles afterwards
    Vasileios Kokkinos
    Department of Physiology, Medical School, University of Patras, Rion, Greece
    J Sleep Res 20:57-72. 2011
    ..This enhancement of spindle frequency could not be correlated to any of the KC parameters studied. The results of this study reveal a consistent interaction between the KC and the sleep spindle during NREM stage II in human sleep...
  19. ncbi Memory consolidation during sleep: interactive effects of sleep stages and HPA regulation
    Ullrich Wagner
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Stress 11:28-41. 2008
    ..We have shown that the different sleep stages and the concomitant glucocorticoid release are interactively involved in the consolidation of different types ..
  20. ncbi Evoked K-complex generation: the impact of sleep spindles and age
    Kate Crowley
    Human Sleep Research Program, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Clin Neurophysiol 115:471-6. 2004
    ..The present study sought to test this hypothesis in young and elderly subjects...
  21. ncbi Cyclic alternating pattern (CAP): the marker of sleep instability
    Liborio Parrino
    Sleep Disorders Center, Department of Neurosciences, University of Parma, Italy
    Sleep Med Rev 16:27-45. 2012
    ....
  22. ncbi Gene expression in the brain across the sleep-waking cycle
    C Cirelli
    The Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, CA 92121, USA
    Brain Res 885:303-21. 2000
    ..Thus, significant changes in gene expression occur across behavioral states, which are likely to affect basic cellular functions such as RNA and protein synthesis, neural plasticity, neurotransmission, and metabolism...
  23. ncbi A review of mentation in REM and NREM sleep: "covert" REM sleep as a possible reconciliation of two opposing models
    T A Nielsen
    Sleep Research Center, Hopital du Sacre Coeur de Montreal, Montreal, Quebec, Canada and Psychiatry Department, Universite de Montreal, Quebec H4J 1C5, Canada
    Behav Brain Sci 23:851-66; discussion 904-1121. 2000
    ..Such covert activity may be responsible for much of the dreamlike cognitive activity occurring in NREM sleep...
  24. ncbi Human alpha oscillations in wakefulness, drowsiness period, and REM sleep: different electroencephalographic phenomena within the alpha band
    Jose L Cantero
    Laboratory of Neurophysiology, Department of Psychiatry, Harvard Medical School, Boston, USA
    Neurophysiol Clin 32:54-71. 2002
    ....
  25. ncbi Functional ADA polymorphism increases sleep depth and reduces vigilant attention in humans
    Valérie Bachmann
    Institute of Pharmacology and Toxicology University of Zurich, Zurich, Switzerland
    Cereb Cortex 22:962-70. 2012
    ..5-12 Hz), sleepiness, fatigue, and α-amylase in saliva were enhanced. These convergent data demonstrate that genetic reduction of ADA activity elevates sleep pressure and plays a key role in sleep and waking quality in humans...
  26. ncbi Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity
    J Hara
    Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Neuron 30:345-54. 2001
    ..Orexin/ataxin-3 mice provide a valuable model for studying the pathophysiology and treatment of narcolepsy...
  27. pmc Sleep and brain energy levels: ATP changes during sleep
    Markus Dworak
    Laboratory of Neuroscience, Department of Psychiatry, Veterans Affairs Boston Healthcare System and Harvard Medical School, West Roxbury, Massachusetts 02132, USA
    J Neurosci 30:9007-16. 2010
    ....
  28. pmc Interpretation of normalized spectral heart rate variability indices in sleep research: a critical review
    Robert L Burr
    School of Nursing, University of Washington, UW Box 357266, Seattle, Washington 98195 7266, USA
    Sleep 30:913-9. 2007
    ..LFnu, HFnu, and LF:HF ratio should be considered equivalent carriers of information about sympathovagal balance...
  29. ncbi A daytime nap containing solely non-REM sleep enhances declarative but not procedural memory
    Matthew A Tucker
    Laboratory of Cognitive Neuroscience and Sleep, The City College of the City University of New York, 138th Street and Convent Ave, New York, NY 10031, USA
    Neurobiol Learn Mem 86:241-7. 2006
    ..These findings are discussed with reference to the general benefits of napping and within the broader context of a growing literature suggesting a role for NREM-specific physiology for the processing of declarative memory...
  30. pmc Thalamic T-type Ca2+ channels and NREM sleep
    Vincenzo Crunelli
    School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, UK
    Cell Calcium 40:175-90. 2006
    ....
  31. ncbi Encoding difficulty promotes postlearning changes in sleep spindle activity during napping
    Christina Schmidt
    Centre for Chronobiology, Psychiatric University Clinics, CH 4025 Basel, Switzerland
    J Neurosci 26:8976-82. 2006
    ..Furthermore, we demonstrate here that the nature of the learning material is a determinant factor for sleep-related alterations after declarative learning...
  32. ncbi Genetic aspects of normal and disturbed sleep
    Mehdi Tafti
    Center for Integrative Genomics, University of Lausanne, Genopode, 1015 Lausanne, Switzerland
    Sleep Med 10:S17-21. 2009
    ....
  33. ncbi Sleep and depression--results from psychobiological studies: an overview
    D Riemann
    Department of Psychiatry and Psychotherapy, University Hospital of Freiburg, Hauptstrasse 5, 79104, Freiburg, Germany
    Biol Psychol 57:67-103. 2001
    ..These data indicate a strong bi-directional relationship between sleep, sleep alterations and depression...
  34. ncbi Circadian pattern of sleep, energy expenditure, and body temperature of young healthy men during the intermittent fasting of Ramadan
    Ahmed BaHammam
    The University Sleep Disorders Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia
    Appetite 54:426-9. 2010
    ..These results support our hypothesis that in addition to sudden shift in meal times, other factors may affect the sleep pattern and circadian rhythms during Ramadan...
  35. ncbi A randomized controlled trial of continuous positive airway pressure in mild obstructive sleep apnea
    Maree Barnes
    Department of Respiratory Medicine, Austin and Repatriation Medical Center, Victoria, Australia
    Am J Respir Crit Care Med 165:773-80. 2002
    ..This placebo effect may account for some of the treatment responses to CPAP observed previously in patients with mild OSA...
  36. ncbi Reduced sleep spindle activity in schizophrenia patients
    Fabio Ferrarelli
    University of Wisconsin, Department of Psychiatry, 6001 Research Park Blvd, Madison, WI 53719, USA
    Am J Psychiatry 164:483-92. 2007
    ..As a first step in this direction, the authors employed high-density EEG to explore whether sleep rhythms differ between schizophrenia subjects, healthy individuals, and a psychiatric control group with a history of depression...
  37. pmc Stratification pattern of static and scale-invariant dynamic measures of heartbeat fluctuations across sleep stages in young and elderly
    Daniel T Schmitt
    Theoretische Physik, Universitat Ulm, D 89069 Ulm, Germany
    IEEE Trans Biomed Eng 56:1564-73. 2009
    ..Changes in sleep regulation during sleep stages are also related to fluctuations in autonomic nervous activity...
  38. pmc Changes in the heart rate variability in patients with obstructive sleep apnea and its response to acute CPAP treatment
    Ernesto Kufoy
    Clinical Neurophysiology Service, University Clinic of Navarra, Pamplona, Spain
    PLoS ONE 7:e33769. 2012
    ....
  39. pmc Comparison of subjective and objective assessments of sleep in healthy older subjects without sleep complaints
    Deirdre O'Donnell
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Sleep Res 18:254-63. 2009
    ....
  40. ncbi A study on gender and age differences in sleep spindles
    Eero Huupponen
    Digital and Computer Systems Laboratory, Tampere University of Technology, Finland
    Neuropsychobiology 45:99-105. 2002
    ..No significant differences in spindle activity of the frontal channels were found between the groups. However, the interindividual spindle variability seemed to be at least as large as that stemming from gender...
  41. ncbi Detrended fluctuation analysis of EEG in sleep apnea using MIT/BIH polysomnography data
    Jong Min Lee
    Department of Biomedical Engineering, College of Medicine, Hanyang University Haengdang dong, Seongdong Ku, 133 791, Seoul, South Korea
    Comput Biol Med 32:37-47. 2002
    ..We found the mean scaling exponents of EEG is discriminated according to Non-REM, REM (Rapid Eye Movement) and waken stage, and gradually increased from stage 1 to stage 2, 3 and 4...
  42. pmc Reduced sleep spindles and spindle coherence in schizophrenia: mechanisms of impaired memory consolidation?
    Erin J Wamsley
    Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, USA
    Biol Psychiatry 71:154-61. 2012
    ..Patients with schizophrenia show dramatic reductions of both spindles and sleep-dependent memory consolidation, which may be causally related...
  43. ncbi Spindle frequency remains slow in sleep apnea patients throughout the night
    Sari Leena Himanen
    Department of Clinical Neurophysiology, Tampere University Hospital, P O Box 2000, FIN 33521 Tampere, Finland
    Sleep Med 4:229-34. 2003
    ..Thus far spindle frequency patterns in patients with sleep disorders have not been studied. It would be expected that the spindle frequencies might be affected by sleep fragmentation disturbing the sleep process...
  44. ncbi Non-linear analysis of EEG signals at various sleep stages
    Rajendra Acharya U
    Department of Electronics and Computer Engineering, School of Engineering, Ngee Ann Polytechnic, 535 Clementi Road, Singapore 599489, Singapore
    Comput Methods Programs Biomed 80:37-45. 2005
    ..b>Sleep stages and sustained fluctuations of autonomic functions such as temperature, blood pressure, electroencephalogram (..
  45. ncbi Environmental noise, sleep and health
    Alain Muzet
    FORENAP, BP 27, Rouffach, France
    Sleep Med Rev 11:135-42. 2007
    ....
  46. ncbi Dynamics of the human EEG during prolonged wakefulness: evidence for frequency-specific circadian and homeostatic influences
    D Aeschbach
    Clinical Psychobiology Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    Neurosci Lett 239:121-4. 1997
    ..It is concluded that the circadian pacemaker and the wake-dependent (i.e. homeostatic) process affect the waking EEG in a frequency-specific manner...
  47. pmc Hemodynamic cerebral correlates of sleep spindles during human non-rapid eye movement sleep
    M Schabus
    Cyclotron Research Centre, University of Liege, B 4000 Liege, and Department of Psychiatry, Centre Hospitalier Universitaire de Liege, Belgium
    Proc Natl Acad Sci U S A 104:13164-9. 2007
    ..The recruitment of partially segregated cortical networks for slow and fast spindles further supports the existence of two spindle types during human non-rapid eye movement sleep, with potentially different functional significance...
  48. pmc Sleep classification according to AASM and Rechtschaffen & Kales: effects on sleep scoring parameters
    Doris Moser
    Department of Neurology, Medical University of Vienna, Vienna, Austria
    Sleep 32:139-49. 2009
    ..To investigate differences between visual sleep scoring according to the classification developed by Rechtschaffen and Kales (R&K, 1968) and scoring based on the new guidelines of the American Academy of Sleep Medicine (AASM, 2007)...
  49. ncbi Sleep spindles: an overview
    Luigi De Gennaro
    Department of Psychology, University of Rome, Italy
    Sleep Med Rev 7:423-40. 2003
    ....
  50. ncbi Exercise training effect on obstructive sleep apnea syndrome
    J F Norman
    Division of Physical Therapy Education, Department of Pulmonary Medicine, University Hospital, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Sleep Res Online 3:121-9. 2000
    ..However, exercise training alone was not an adequate intervention strategy for most individuals with OSAS but may serve well as an adjunct treatment strategy in the conservative management of individuals with mild to moderate OSAS...
  51. ncbi Computer-assisted sleep classification according to the standard of the American Academy of Sleep Medicine: validation study of the AASM version of the Somnolyzer 24 × 7
    Peter Anderer
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Wahringer Gurtel 18 20, Vienna, Austria
    Neuropsychobiology 62:250-64. 2010
    ..Concerning the visual classification of sleep stages, these new rules are intended to replace the rules by Rechtschaffen and Kales (R&K).
  52. pmc Periodic limb movements in sleep exhibit a circadian rhythm that is maximal in the late evening/early night
    Jeanne F Duffy
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Sleep Med 12:83-8. 2011
    ..Our study aimed to determine whether this pattern is due to an endogenous circadian rhythm, like that in the related movement disorder Restless Legs Syndrome (RLS)...
  53. ncbi Sleep architecture, slow wave activity, and sleep spindles in adult patients with sleepwalking and sleep terrors
    F Espa
    INSERM E 9930, CRLC Val d Aurelle, 34298, Montpellier, France
    Clin Neurophysiol 111:929-39. 2000
    ....
  54. pmc Time structure analysis of leg movements during sleep in REM sleep behavior disorder
    Mauro Manconi
    Sleep Disorders Center, Department of Neurology, H San Raffaele Scientific Institute, Universita Vita Salute San Raffaele, Milan, Italy
    Sleep 30:1779-85. 2007
    ..To compare the time structure of leg movements (LM) during sleep of patients with rapid eye movement (REM) sleep behavior disorder (RBD) with that of patients with restless legs syndrome (RLS) or control subjects...
  55. ncbi Homeostatic sleep response to naps is similar in normal elderly and young adults
    Ian G Campbell
    UCD Sleep Laboratory, Department of Psychiatry and Behavioral Sciences, University of California, Davis, CA 95616, USA
    Neurobiol Aging 26:135-44. 2005
    ..REM sleep showed no homeostatic reductions following naps in either group. We believe that the striking differences in the delta and REM responses point to different biological roles of the two kinds of sleep...
  56. ncbi Effects of humid heat exposure in later sleep segments on sleep stages and body temperature in humans
    Kazue Okamoto-Mizuno
    National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305 8566, Japan
    Int J Biometeorol 49:232-7. 2005
    This study sought to investigate the effects of humid heat exposure in later sleep segments on sleep stages and body temperature in humans. The subjects were eight healthy males, from whom informed consent had been obtained...
  57. ncbi Micro- and macrostructure of sleep EEG
    Urszula Malinowska
    Department of Biomedical Physics, Warsaw University, Poland
    IEEE Eng Med Biol Mag 25:26-31. 2006
  58. pmc Enhancement of declarative memory performance following a daytime nap is contingent on strength of initial task acquisition
    Matthew A Tucker
    Laboratory of Cognitive Neuroscience and Sleep, Department of Psychology, Program in Cognitive Neuroscience, The City College of the City University of New York, New York, NY, USA
    Sleep 31:197-203. 2008
    ..After the nap period, all subjects remained in the lab until retest at 16:00...
  59. ncbi A rule-based automatic sleep staging method
    Sheng Fu Liang
    Department of Computer Science and Information Engineering, National Cheng Kung University, Tainan 701, Taiwan
    J Neurosci Methods 205:169-76. 2012
    ..68% and 0.79, respectively. This method can integrate with portable PSG system for sleep evaluation at-home in the near future...
  60. ncbi The slow-wave components of the cyclic alternating pattern (CAP) have a role in sleep-related learning processes
    Raffaele Ferri
    Sleep Research Centre, Department of Neurology I C, Oasi Institute for Research on Mental Retardation and Brain Aging IRCCS, Via Conte Ruggero 73, Troina, Italy
    Neurosci Lett 432:228-31. 2008
    ..Sleep EEG was recorded for 2h and subjects were also tested after the night following the rotation task. Sleep stages and CAP (classified into three subtypes: A1, A2, and A3) were identified in the first hour of each recording...
  61. ncbi A study of the dynamic interactions between sleep EEG and heart rate variability in healthy young men
    F Jurysta
    Sleep Laboratory, Department of Psychiatry, Erasme Academic Hospital, Free University of Brussels, 1070 Brussels, Belgium
    Clin Neurophysiol 114:2146-55. 2003
    ..We investigated the interactions between heart rate variability and sleep electroencephalogram power spectra...
  62. ncbi Relationship between blood pressure, sleep K-complexes, and muscle sympathetic nerve activity in humans
    Jens Tank
    HELIOS Klinikum Berlin, Clinical Research Center, Franz Volhard Clinic, Charite Campus Buch, Humboldt Univ Berlin, Wiltberg Str 50, 13125 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 285:R208-14. 2003
    ..Their functional effects appear to be independent of baroreflex modulation of MSNA in approximately 50% of the cases...
  63. ncbi A longitudinal study of sleep stages in young women during pregnancy and postpartum
    H S Driver
    Edblo Sleep Laboratory, Department of Physiology, University of the Witwatersrand Medical School, South Africa
    Sleep 15:449-53. 1992
    ..Future research into the effects of cortisol and progesterone is indicated...
  64. ncbi Sleep stage scoring using the neural network model: comparison between visual and automatic analysis in normal subjects and patients
    N Schaltenbrand
    Institute for Research in Neurosciences and Psychiatry, Centre Hospitalier, Rouffach, France
    Sleep 19:26-35. 1996
    ....
  65. ncbi EEG characteristics prior to and following the evoked K-Complex
    C H Bastien
    Universite Laval
    Can J Exp Psychol 54:255-65. 2000
    ..These results tend to support the notion that the K-Complex appears to prevent arousal...
  66. ncbi Effects of NREM sleep instability on cognitive processing
    Debora Arico
    Department of Neurology I C, Oasi Institute for Research on Mental Retardation and Brain Aging IRCCS, Troina, Italy
    Sleep Med 11:791-8. 2010
    ..We tested the hypothesis that CAP subtypes differentially correlate with cognitive functions...
  67. ncbi Tumor necrosis factor (TNF) ligand and TNF receptor deficiency affects sleep and the sleep EEG
    Tom Deboer
    Institute of Pharmacology and Toxicology, CH 8057, Switzerland
    J Neurophysiol 88:839-46. 2002
    ..Our data suggest that in Ligand KO the SWA increase is caused by an increase in excitatory input to the cortex, whereas in R1KO this input seems to be almost absent...
  68. ncbi Computer-assisted sleep staging
    R Agarwal
    Stellate Systems, 345 Victoria Ave, Suite 300, Montreal, QC H3Z 2N2, Canada. ragarwalstellate.com
    IEEE Trans Biomed Eng 48:1412-23. 2001
    ..6% with manual scoring of 20-s epochs according to RK standard. The greatest amount of errors occurred in the identification of the highly transitional Stage 1, 54% of which was misclassified into neighboring stages 2 or Wake...
  69. ncbi Effect of continuous heat exposure on sleep stages in humans
    J P Libert
    Laboratoire de Physiologie et de Psychologie Environnementales, Strasbourg, France
    Sleep 11:195-209. 1988
    ..Therefore, a complete analysis of the effect of heat on sleep parameters can be assessed only if heat exposure is compared with both baseline and recovery periods...
  70. ncbi The effect of self-awakening from nocturnal sleep on sleep inertia
    Hiroki Ikeda
    Department of Behavioral Sciences, Graduate School of Integrated Arts and Sciences, Hiroshima University, 1 7 1 Kagamiyama, Higashi Hiroshima, Japan
    Biol Psychol 83:15-9. 2010
    ..The results of this study suggest that sleep inertia occurs after forced-awakening and that it can be prevented by self-awakening...
  71. ncbi Evaluation of EEG cyclic alternating pattern during sleep in insomniacs and controls under placebo and acute treatment with zolpidem
    M G Terzano
    Department of Neurology, University of Parma, Italy
    Sleep 15:64-70. 1992
    ..Our findings suggest that CAP rate in sleep analysis can represent a useful tool for the diagnosis of insomnia and for gaining insight into the therapeutic efficacy of hypnotic-sedative drugs...
  72. ncbi Gender and age differences in polysomnography findings and sleep complaints of patients referred to a sleep laboratory
    A Silva
    Departamento de Psicobiologia, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil
    Braz J Med Biol Res 41:1067-75. 2008
    ..0 +/- 10.5 vs 55.2 +/- 10.1) of non-REM sleep than women, whereas women spent significantly more time in deep sleep stages (3 and 4) than men (22.6 +/- 9.0 vs 19.9 +/- 9.0)...
  73. ncbi Intrinsic correlations of electroencephalography rhythms with cerebral hemodynamics during sleep transitions
    Mariko Uchida-Ota
    Core Research for Evolutional Science and Technology CREST, Japan
    Neuroimage 42:357-68. 2008
    ..The former correlations were found in the inferior frontal and middle temporal gyri and the latter correlations were found in the superior frontal, middle frontal, and angular gyri...
  74. pmc The slow (<1 Hz) rhythm of non-REM sleep: a dialogue between three cardinal oscillators
    Vincenzo Crunelli
    School of Biosciences, Cardiff University, Cardiff, UK
    Nat Neurosci 13:9-17. 2010
    ....
  75. ncbi Chronic insomnia is associated with nyctohemeral activation of the hypothalamic-pituitary-adrenal axis: clinical implications
    A N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 86:3787-94. 2001
    ..The therapeutic goal in insomnia should be to decrease the overall level of physiologic and emotional arousal, and not just to improve the nighttime sleep...
  76. ncbi Role of snoring and daytime sleepiness in occupational accidents
    E Lindberg
    Department of Medical Sciences, Respiratory Medicine and Allergology, Akademiska sjukhuset, Uppsala, Sweden
    Am J Respir Crit Care Med 164:2031-5. 2001
    ..We conclude that sleepy, male snorers have an increased risk of occupational accidents. The results indicate that early identification and treatment of sleep-disordered breathing may reduce the number of injuries at work...
  77. pmc State-dependent spike-timing relationships between hippocampal and prefrontal circuits during sleep
    Casimir M Wierzynski
    Computation and Neural Systems Program, Division of Biology, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA 91125, USA
    Neuron 61:587-96. 2009
    ..These findings suggest that SWR events are atomic units of hippocampal-prefrontal communication during SWS and that the coupling between these areas is highly attenuated during REM sleep...
  78. ncbi Gamma EEG dynamics in neocortex and hippocampus during human wakefulness and sleep
    Jose L Cantero
    Department of Neurosurgery, Children s Hospital, and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA
    Neuroimage 22:1271-80. 2004
    ..These findings demonstrate a functional link between different stages of conscious awareness and the level of coupling of gamma-band oscillations in the human brain...
  79. ncbi Heart rate variability during sleep and sleep apnoea in a population based study of 387 women
    Milos Kesek
    Department of Cardiology, Heart Centre, Norrland University Hospital, Umea, Sweden
    Clin Physiol Funct Imaging 29:309-15. 2009
    ..We have studied HRV in different sleep stages and related the HRV-pattern to sleep apnoea in a population-based sample of 387 women...
  80. ncbi Directionality of coupling of physiological subsystems: age-related changes of cardiorespiratory interaction during different sleep stages in babies
    Ralf Mrowka
    Johannes Müller Institut für Physiologie, Humboldt Universitat zu Berlin, Tucholskystrasse 2, D 10117 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 285:R1395-401. 2003
    ..The directional analysis may be applied to other interacting narrow band oscillatory systems, e.g., in the central nervous system. Thus it is an important step forward in revealing and understanding causal mechanisms of interactions...
  81. ncbi A replication of the 5-7 day dream-lag effect with comparison of dreams to future events as control for baseline matching
    Mark Blagrove
    Department of Psychology, Swansea University, UK
    Conscious Cogn 20:384-91. 2011
    ..This may indicate a memory processing function for sleep, which the dream content may reflect. Participants' and three independent judges' mean ratings also confirmed a significant day-residue effect...
  82. pmc The role of sleep in false memory formation
    Jessica D Payne
    Center for Sleep and Cognition, Department of Psychiatry, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Neurobiol Learn Mem 92:327-34. 2009
    ..While these effects produce memories that are less accurate after sleep, these memories may, in the end, be more useful...
  83. ncbi Compensatory sleep response to 12 h wakefulness in young and old rats
    P J Shiromani
    West Roxbury Veterans Affairs Medical Center and Harvard Medical School, West Roxbury 02132, Massachusetts, USA
    Am J Physiol Regul Integr Comp Physiol 278:R125-33. 2000
    ..The findings also indicate that although old rats have a decline in sleep, this cannot be attributed to loss of VLPO neurons implicated in sleep...
  84. ncbi Distinct sleep-wake stages in rats depend differentially on age
    Roumen Kirov
    Institute of Physiology, Bulgarian Academy of Sciences, Academic Georgi Banchev street, Block 23, 1113 Sofia, Bulgaria
    Neurosci Lett 322:134-6. 2002
    ..No age changes were found for QW and PS. It is suggested that the consolidation of SWS is primarily disturbed in the old rats, which may lead to a facilitation of wake...
  85. ncbi Interobserver agreement among sleep scorers from different centers in a large dataset
    R G Norman
    Department of Pulmonary and Critical Care Medicine, NYU School of Medicine, New York, NY 10016, USA
    Sleep 23:901-8. 2000
    ..This warrants caution when comparing data scored in separate laboratories. The lower agreement in SDB patients supports the generally held view that sleep fragmentation makes application of the R&K rules less reliable...
  86. ncbi The whats and whens of sleep-dependent memory consolidation
    Susanne Diekelmann
    University of Lubeck, Department of Neuroendocrinology, 23538 Lubeck, Germany
    Sleep Med Rev 13:309-21. 2009
    ....
  87. ncbi Experimental evaluation of eye-blink parameters as a drowsiness measure
    Philipp P Caffier
    Federal Institute for Occupational Safety and Health, Noeldnerstrasse 40 42, 10317 Berlin, Germany
    Eur J Appl Physiol 89:319-25. 2003
    ..The results demonstrate that the measurement of eye blink parameters provides reliable information about drowsiness/sleepiness, which may also be applied to the continuous monitoring of the tendency to fall asleep...
  88. ncbi Dreaming and episodic memory: a functional dissociation?
    Magdalena J Fosse
    Laboratory of Neurophysiology, Harvard Medical School, Massachusetts Mental Health Center, Boston 02115, USA
    J Cogn Neurosci 15:1-9. 2003
    ..This finding has implications for understanding the unique memory processing that takes place during the night and is consistent with evidence that sleep has no role in episodic memory consolidation...
  89. ncbi Behavioral state instability in orexin knock-out mice
    Takatoshi Mochizuki
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Neurosci 24:6291-300. 2004
    ..Instead, the fragmented behavior of orexin KO mice may be best described as behavioral state instability, with apparently low thresholds to transition between states...
  90. ncbi Daytime sleepiness and neural cardiac modulation in sleep-related breathing disorders
    Carolina Lombardi
    Center for Sleep Disorders, Department of Neurological Sciences, University of Bologna, Bologna, Italy
    J Sleep Res 17:263-70. 2008
    ....
  91. ncbi EEG-based lapse detection with high temporal resolution
    Paul R Davidson
    Van der Veer Institute for Parkinson s and Brain Research, Christchurch, New Zealand
    IEEE Trans Biomed Eng 54:832-9. 2007
    ..Overall performance was satisfactory with area under the curve from receiver operating characteristic analysis of 0.84 +/- 0.02 (mean +/- SE) and area under the precision-recall curve of 0.41 +/- 0.08...
  92. pmc Variability of QT interval duration in obstructive sleep apnea: an indicator of disease severity
    Mathias Baumert
    School of Electrical and Electronic Engineering, Centre for Biomedical Engineering, University of Adelaide, Adelaide, Australia
    Sleep 31:959-66. 2008
    ..To determine OSA-related changes in variability of QT interval duration and in heart rate variability (HRV), and to evaluate the relationship of these parameters to disease severity...
  93. ncbi Theta activity in the waking EEG is a marker of sleep propensity in the rat
    Vladyslav V Vyazovskiy
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstr, 190 CH 8057 Zurich, Switzerland
    Brain Res 1050:64-71. 2005
    ..The results indicate that in rats, as in humans, a specific waking EEG frequency, i.e., theta power in quiet waking is a marker of sleep propensity...
  94. ncbi The K-complex: a 7-decade history
    Ian M Colrain
    Human Sleep Research Program, SRI international and Department of Psychology, The University of Melbourne, Melbourne, Australia
    Sleep 28:255-73. 2005
    ....
  95. ncbi Comparison of detrended fluctuation analysis and spectral analysis for heart rate variability in sleep and sleep apnea
    Thomas Penzel
    Division of Pulmonary Diseases, Department of Internal Medicine, Hospital of Philipps University, Baldingerstrasse 1, D 35033 Marburg, Germany
    IEEE Trans Biomed Eng 50:1143-51. 2003
    ..has been regarded as a testing situation for the autonomic nervous system, because its activity is modulated by sleep stages. Sleep-related breathing disorders also influence the autonomic nervous system and can cause heart rate changes ..
  96. pmc Stress-induced changes in sleep in rodents: models and mechanisms
    Aaron C Pawlyk
    Women s Health and Musculoskeletal Biology, Wyeth Research, Collegeville, PA 19426, USA
    Neurosci Biobehav Rev 32:99-117. 2008
    ..A complete understanding of the neural correlates of stress-induced sleep alterations may lead to novel treatments for a variety of debilitating sleep disorders...
  97. ncbi Autonomic function in sleep apnea patients: increased heart rate variability except during REM sleep in obese patients
    Erica B Reynolds
    Eastern Virginia Medical School, Sentara Norfolk General Hospital, Norfolk, USA
    Sleep Breath 11:53-60. 2007
    The objective of this study was to examine heart rate variability (HRV) among sleep stages in obstructive sleep apnea (OSA) patients...
  98. ncbi Minimal olfactory perception during sleep: why odor alarms will not work for humans
    Mary A Carskadon
    Department of Psychiatry and Human Behavior, Sleep Research Laboratory, Brown Medical School Bradley Hospital, Providence, RI 02906, USA
    Sleep 27:402-5. 2004
    ..To examine olfactory arousal threshold during sleep in comparison to an auditory tone...
  99. ncbi The nature of arousal in sleep
    Peter Halasz
    Neurological Department, National Institute of Psychiatry and Neurology, Budapest, Hungary
    J Sleep Res 13:1-23. 2004
    ..In this perspective, arousals shape the individual course of night sleep as a variation of the sleep program...
  100. pmc Circadian desynchronization of core body temperature and sleep stages in the rat
    Trinitat Cambras
    Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Barcelona 08028, Spain
    Proc Natl Acad Sci U S A 104:7634-9. 2007
    ..This model now allows for a deeper understanding of the human timekeeping mechanism, for testing potential therapies for circadian dysrhythmias, and for studying the biology of PS and SWS states in a neurologically intact model...
  101. pmc The time course of adenosine, nitric oxide (NO) and inducible NO synthase changes in the brain with sleep loss and their role in the non-rapid eye movement sleep homeostatic cascade
    Anna V Kalinchuk
    Laboratory of Neuroscience, Department of Psychiatry, VA Boston Healthcare System and Harvard Medical School, West Roxbury, Massachusetts, USA
    J Neurochem 116:260-72. 2011
    ..These data support the role of BF adenosine and NO in sleep homeostasis and indicate the temporal and spatial sequence of sleep homeostatic cascade for NO and adenosine...

Research Grants63

  1. Orexin Receptor Agonists for the Treatment of Excessive Daytime Sleepiness and Ca
    PAUL STUART HUMPHRIES; Fiscal Year: 2013
    ..vivo mouse model of narcolepsy utilizes proprietary sleep EEG software that is essential for reliably analyzing sleep stages in rodents...
  2. Effects of sleep duration and architecture on insulin sensitivity
    MADHU NAGARAJU RAO; Fiscal Year: 2013
    ..large cohort study and a pilot clinical trial, we will assess: (1) the association between sleep architecture (sleep stages determined by polysomnography) and insulin sensitivity and (2) the specific sites of insulin resistance (ie, ..
  3. Feasibility of Measuring Sleep in a Critical Care Environment
    Margaret A Pisani; Fiscal Year: 2010
    ..3. Ability to obtain EEG data to examine sleep latency, sleep stages, and sleep duration...
  4. Complex Dynamic Systems in Mood Disorders
    Andrew A Nierenberg; Fiscal Year: 2010
    ..The pilot project will analyze measures of arousal, heart rate, respiration, movement, and sleep stages using a 24 hour wearable devices from 5 patients with MDD, 5 age and sex matched patients with BP, and 5 ..
  5. Hippocampal Network Dynamics during Sleep
    Athanassios G Siapas; Fiscal Year: 2012
    ..This raises several key questions: What differential roles, if any, do these two sleep stages play in memory consolidation? How are these roles supported by the neural activity patterns of SWS and REM? And ..
  6. STATE DEPENDENT ASPECTS OF COGNITION
    Robert Stickgold; Fiscal Year: 2013
    ..types of memory are consolidated during sleep? Which components of consolidation occur during sleep? Which sleep stages mediate this consolidation? And what physiological processes underlie sleep-dependent consolidation? To date, ..
  7. Mechanisms for Sleep-Dependent Cortical Plasticity
    Sara J Aton; Fiscal Year: 2010
    ..To test the roles of REM and NREM sleep in ODP, we will selectively manipulate these sleep stages following a period of MD...
  8. Metabolic and KATP channel regulation of the cortical slow oscillation
    Andrew Lutas; Fiscal Year: 2013
    ..These channels have recently been shown to regulate a cortical (<1 Hz) slow oscillation. During deep sleep stages or anesthesia, cortical neurons oscillate between two states: an up-state during which neurons are depolarized ..
  9. Novel Algorithms and Device for Quantification of Wake-Sleep States
    STEPHANE BIBIAN; Fiscal Year: 2010
    ..easily deployable by the patient), fully-automated, and (highly) quantitative analyzer of brain waves and wake-sleep stages for extended night- time sleep, and daytime sleepiness, and for use in the patients'normal home ..
  10. Perceptual Learning and Sleep
    Takeo Watanabe; Fiscal Year: 2013
    ..Imaging will be conducted with concurrent polysomnography measurement to objectively identify sleep stages. Successful research results would provide significant knowledge to clarify how improvement of perceptual ..
  11. Sleep-dependent Memory Processing in Older Adults
    Rebecca M C Spencer; Fiscal Year: 2013
    ..Sleep's function on declarative and procedural learning is unique, each being associated with distinct sleep stages and physiological markers. Therefore, we will separately probe declarative and procedural learning...
  12. Polysomnography in Homeopathic Remedy Effects
    Iris Bell; Fiscal Year: 2007
    ..To evaluate the effects of two different active homeopathic remedies versus placebo on standard sleep stages and spectral EEG in human subjects; and II...
  13. CARDIORESPIRATORY TRANSFER IN OBSTRUCTIVE SLEEP APNEA
    MICHAEL KHOO; Fiscal Year: 2000
    ..will provide randomized levels of respiratory assistance and randomly-occurring occlusions during various sleep stages. These perturbations will enhance the model-parameter estimation process by reducing correlation among the ..
  14. Functional near-infrared imaging using the phase of hemodynamic oscillations
    Angelo Sassaroli; Fiscal Year: 2012
    ..This new analysis will allow us to test the hypothesis that hemodynamic conditions associated with different sleep stages induce different phase relationship between spontaneous oscillations of oxy-hemoglobin and deoxy-hemoglobin ..
  15. SLEEP, AGING, AND THE HYPOCRETIN/OREXIN SYSTEM
    THOMAS KILDUFF; Fiscal Year: 2007
    ..To address these questions, we will use a combination of in vivo physiological, neuroanatomical, molecular, and receptor pharmacological methods. ..
  16. TYMPANIC TEMPERATURE AND SLOW WAVE SLEEP IN HUMANS
    Ralph Berger; Fiscal Year: 1990
    ..Similar correlations will be computed between SWS (stages 3 + 4) and Tb measures, and between other sleep stages and Tb measures...
  17. ABSOLUTE NEAR-INFRARED BRAIN OXIMETER
    Antonios Michalos; Fiscal Year: 2000
    ..Conventional polysomnography, a relatively expensive test, detects sleep apnea at various sleep stages and determines arterial oxygen saturation...
  18. CIRCADIAN REGULATION OF METABOLISM IN THE PIGEON
    Ralph Berger; Fiscal Year: 1991
    ..Raster and spectral plots of Tb, BW, ACT, F and sleep stages in each condition will be compared...
  19. Sleep Fatigue & Cognitive Correlates in Pediatric HIV
    Randi Streisand; Fiscal Year: 2007
    ..Specific aims include: 1) to describe abnormalities in the organization of sleep stages and to estimate prevalence rates of sleep disorders in HIV infected pediatric patients; and 2) to use objective ..
  20. HIGH RESOLUTION EEG FOR POLYSOMNOGRAPHY
    DON TUCKER; Fiscal Year: 2000
    ..and polysomnographic measures, and it would segment the EEG into microstates of arousal as well as traditional sleep stages. The system would advance the technology of clinical sleep laboratories, providing new methods of dense array ..
  21. Experimental manipulation of sleep mentation and memory
    Robert Stickgold; Fiscal Year: 2006
    ..use reports of sleep mentation to provide support for the hypothesis that, during the night and across multiple sleep stages, waking memories are reprocessed through a series of distinct steps that aid in their consolidation and ..
  22. The Role of Sleep in Perceptual Learning
    Takeo Watanabe; Fiscal Year: 2009
    ..magnetic resonance imaging (fMRI), so that we can objectively determine the onset/offset of sleep and sleep stages using the most standard method in sleep studies...
  23. PREVALENCE OF SLEEP DISORDERED BREATHING IN CHILDREN
    Edward Bixler; Fiscal Year: 2005
    ..the effects of SDB on physical health (eg blood pressure); academic achievement; or electrophysiologic defined sleep stages as possible outcome measures...
  24. fMRI VIsualization Of The Human Brain During Sleep Onset
    Robert Stickgold; Fiscal Year: 2005
    ..more recently, PET has revealed complex dissociated patterns of functional neuroanatomy associated with the sleep stages of NREM and REM, findings that past electrophysiological studies could only hint at...
  25. SLEEP AND ENTERTAIMENT OF SCN FUNCTION
    Kingman Strohl; Fiscal Year: 2002
    ..Measures will include sleep architecture (sleep onset, sleep stages, sleep duration), and its physiologic correlates (respiratory rate, heart rate, and metabolic rate), with ..
  26. DREAMS, LANGUAGE, AND COGNITION
    DAVID FOULKES; Fiscal Year: 1980
    ..which these sources undergo in dream formation; comparisons of dream constructional processes in different sleep stages; and contrast of the associative mechanisms underlying waking and sleeping thought...
  27. SLEEP CIRCADIAN RHYTHMS ACTIVITY AND THE HEART
    Christian Guilleminault; Fiscal Year: 1993
    ..This investigation will involve the roles of sleep states, sleep stages, inactivity, the supine position, and the placement of sleep in the 24-hour cycle on the occurrence of the ..
  28. Novel Real-Time Algorithms:Quantifying Wake-Sleep States
    MOHAMMAD MODARRES ZADEH; Fiscal Year: 2004
    ..designed for high temporal resolution characterization of the wake-sleep transition and fluctuations within sleep stages. In addition to their capability of profiling wakefulness and various sleep stages as a continuous process, ..
  29. Sleep Architecture: Individuals With Mental Retardation
    Craig Kennedy; Fiscal Year: 2004
    ..A more precise analysis of sleep and individual sleep stages is needed. The investigators propose to use polysomnography (i.e...
  30. Hemodynamic Responses to Apnea in Strains
    Matthew Campen; Fiscal Year: 2001
    ..The second specific aim will be to examine strain differences in hemodynamics during sleep stages. The third specific aim will address changes in hypoxic and hypercapnic responsiveness resulting from CIH ..
  31. Neural Basis of Sleep-Dependent Learning & Deterioration
    Sara Mednick; Fiscal Year: 2006
    ..Specific sleep stages have been associated with improvement on different tasks...
  32. Mechanisms Underlying the Cognitive Function of Sleep
    Subimal Datta; Fiscal Year: 2009
    ....
  33. Alcohol, Sleep and Brain Development
    IAN COLRAIN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  34. Alcoholism, Sleep and the Brain
    IAN COLRAIN; Fiscal Year: 2007
    ..Hypothesis 4: Small amplitude, production rate and power of sleep electrophysiological variables in recently detoxified alcoholics will predict early relapse. ..
  35. Spectrum of Narcolepsy in the Probands Families
    MAURICE OHAYON; Fiscal Year: 2007
    ..A blood sample (3-5 ml) will be asked also to all participants. This will allow us to link some genetic markers of narcolepsy to specific symptoms even in subjects without the full-fledge manifestation of the disease. ..
  36. ECG-derived estimators of sleep physiology
    Robert Thomas; Fiscal Year: 2006
    ..3) To correlate the biomarker with excessive daytime sleepiness, subjective sleep quality and cardiovascular morbidity (SHHS), and reduced neurocognitive function (NAPS). ..
  37. Biomarkers of Aging in the Bay Area Sleep Cohort
    Donald Bliwise; Fiscal Year: 2005
    ..abstract_text> ..
  38. Electrophysiological Action of GHB in Brain Reward Areas
    Vincenzo Crunelli; Fiscal Year: 2003
    ....
  39. WORKING MEMORY IN OBSTRUCTIVE SLEEP APNEA-AN fMRI STUDY
    Robert Thomas; Fiscal Year: 2006
    ..abstract_text> ..
  40. SUNDOWN SYNDROME IN A SKILLED NURSING FACILITY
    Donald Bliwise; Fiscal Year: 2002
    ..These results will provide information on the mechanistic basis for sundowning in aged patients with dementing disorders. ..
  41. Predisposition Model of Insomnia
    Christopher Drake; Fiscal Year: 2008
    ..abstract_text> ..
  42. Polysomnographic Assessment of Alternative Treatment
    Donald Bliwise; Fiscal Year: 2006
    ..abstract_text> ..
  43. Sleep/Wake Contiuum in Lewy Body Disease
    Donald L Bliwise; Fiscal Year: 2010
    ..The proposed work will also provide important clinical insights into disease correlates and disease course across the broad spectrum of Parkinsonism. ..
  44. SLEEP AS A MEDIATOR OF THE STRESS/HEALTH RELATIONSHIP
    Martica Hall; Fiscal Year: 2002
    ....
  45. FACILITATION OF EPILEPTIC ACTIVITY BY SLEEP AND AROUSAL
    Beth Malow; Fiscal Year: 2003
    ..abstract_text> ..
  46. Impact of Sleep Disruption on Menstrual Cycle Dynamics
    ELIZABETH KLERMAN; Fiscal Year: 2004
    ..abstract_text> ..
  47. Functional Changes Induced By Sleep Deprivation
    Giulio Tononi; Fiscal Year: 2004
    ..These studies should provide insights into the molecular consequences of prolonged sleep deprivation and chronic insomnia and suggest new therapeutic approaches. ..
  48. Effects of Treating Obstructive Sleep Apnea in Epilepsy
    Beth Malow; Fiscal Year: 2004
    ..Develop quality control measures to ensure accurate and consistent data collection among sites in the RCT, including aspects related to remote data entry and standardization of performance and interpretation of PSG studies across sites...
  49. Melatonin for Sleep in Children with Autism: Safety, Tolerability, and Dosing
    Beth Malow; Fiscal Year: 2009
    ..We will determine the response of melatonin dose on sleep latency using polysomnography and actigraphy, a validated and non-intrusive measure of sleep onset and duration. Adverse events will also be captured. ..
  50. THE ROLE OF CYTOKINES IN SLEEPINESS AND SLEEP APNEA
    Alexandros Vgontzas; Fiscal Year: 2009
    ..These studies collectively will provide additional evidence for a role of TNFa and IL-6 in EDS and OSA and lay the foundation for the development of novel therapeutic interventions. ..
  51. IMPACT OF SYNAPTIC BOMBARDMENT ON NEOCORTICAL NEURONS
    Mircea Steriade; Fiscal Year: 2001
    ..The potential impact of this study for the modeling community is therefore broad, from models of information processing to the simulations of pathological states, such as epilepsy. ..
  52. Local Sleep Regulation and Brain Plasticity
    Giulio Tononi; Fiscal Year: 2010
    ..Thus, they are highly relevant to the mission of MINDS, NIMH, and NHLBI. ..
  53. Impact of Sleep Disruption on Menstrual Cycle Dynamics
    ELIZABETH KLERMAN; Fiscal Year: 2008
    ....
  54. Sleep Neuroscience in Depression
    Eric Nofzinger; Fiscal Year: 2009
    ..Multiple linear regressions will be used to test the mediational models above. Findings from this study are expected to significantly advance our understanding of the neuroscience of depression. ..
  55. Sleep Apnea and Obesity: Cardiovascular Risk Assessment
    Atul Malhotra; Fiscal Year: 2008
    ..This data may have important implications for the diagnosis and treatment of these abnormalities. ..
  56. RISK FACTORS FOR ALCOHOLISM IN NATIVE AMERICANS
    Cindy Ehlers; Fiscal Year: 2006
    ..The identification of such variables may potentially be useful in the development of specific prevention and treatment programs for this population as well as other Native American tribes. ..
  57. ANALGESIC REGIMENS FOR SURGERY AND INFLAMMATION IN MICE
    LINDA TOTH; Fiscal Year: 2006
    ..The data should reveal new and practical strategies for relief of post-procedural pain in mice. ..
  58. Relating sleep disordered breathing to daytime function
    INDU A AYAPPA; Fiscal Year: 2010
    ..Validating a measure of sleep disordered breathing that relates to sleepiness will help improve the diagnosis and treatment of obstructive sleep apnea. ..
  59. The Effects of Hemodialysis on the Sleep/Wake Cycle
    Kathy Parker; Fiscal Year: 2007
    ..In addition, study results will make a significant contribution to the scientific understanding of how medical treatments may interact with normal systems to induce sleep/wake abnormalities. ..
  60. Sleep-Health & Knowledge in U.S. Hispanics
    JOSE LOREDO; Fiscal Year: 2009
    ..S. Mexican-American Hispanics should include intensive focus on Sleep Health and Sleep Health knowledge deficits. Key Words: Sleep disorders;Minority health;Epidemiology. ..
  61. BEHAVIORAL AND PHARMACOLOGICAL TREATMENT FOR INSOMNIA
    Charles Morin; Fiscal Year: 2005
    ....
  62. Phylogeny of Sleep
    Patrick McNamara; Fiscal Year: 2007
    ..abstract_text> ..