sleep

Summary

Summary: A readily reversible suspension of sensorimotor interaction with the environment, usually associated with recumbency and immobility.

Top Publications

  1. ncbi The memory function of sleep
    Susanne Diekelmann
    University of Lubeck, Department of Neuroendocrinology, 23538 Lubeck, Germany
    Nat Rev Neurosci 11:114-26. 2010
  2. pmc Rules for scoring respiratory events in sleep: update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events. Deliberations of the Sleep Apnea Definitions Task Force of the American Academy of Sleep Medicine
    Richard B Berry
    University of Florida Health Science Center, Gainesville, FL 32610, USA
    J Clin Sleep Med 8:597-619. 2012
  3. ncbi Sleep function and synaptic homeostasis
    Giulio Tononi
    Department of Psychiatry, University of Wisconsin, 6001 Research Park Blvd, Madison, WI 53719, USA
    Sleep Med Rev 10:49-62. 2006
  4. ncbi Memory of sequential experience in the hippocampus during slow wave sleep
    Albert K Lee
    Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 36:1183-94. 2002
  5. ncbi Hypothalamic regulation of sleep and circadian rhythms
    Clifford B Saper
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, USA
    Nature 437:1257-63. 2005
  6. pmc Control of sleep and wakefulness
    Ritchie E Brown
    Laboratory of Neuroscience, VA Boston Healthcare System and Harvard Medical School, Brockton, Massachusetts 02301, USA
    Physiol Rev 92:1087-187. 2012
  7. ncbi Breakdown of cortical effective connectivity during sleep
    Marcello Massimini
    Department of Psychiatry, University of Wisconsin, Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA
    Science 309:2228-32. 2005
  8. pmc Sleep state switching
    Clifford B Saper
    Department of Neurology, Program in Neuroscience, and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Neuron 68:1023-42. 2010
  9. ncbi Local sleep and learning
    Reto Huber
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin 53719, USA
    Nature 430:78-81. 2004
  10. pmc About sleep's role in memory
    Björn Rasch
    Division of Biopsychology, Neuroscience Center Zurich, University of Zurich, Zurich, Switzerland
    Physiol Rev 93:681-766. 2013

Detail Information

Publications305 found, 100 shown here

  1. ncbi The memory function of sleep
    Susanne Diekelmann
    University of Lubeck, Department of Neuroendocrinology, 23538 Lubeck, Germany
    Nat Rev Neurosci 11:114-26. 2010
    b>Sleep has been identified as a state that optimizes the consolidation of newly acquired information in memory, depending on the specific conditions of learning and the timing of sleep...
  2. pmc Rules for scoring respiratory events in sleep: update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events. Deliberations of the Sleep Apnea Definitions Task Force of the American Academy of Sleep Medicine
    Richard B Berry
    University of Florida Health Science Center, Gainesville, FL 32610, USA
    J Clin Sleep Med 8:597-619. 2012
    The American Academy of Sleep Medicine (AASM) Sleep Apnea Definitions Task Force reviewed the current rules for scoring respiratory events in the 2007 AASM Manual for the Scoring and Sleep and Associated Events to determine if revision ..
  3. ncbi Sleep function and synaptic homeostasis
    Giulio Tononi
    Department of Psychiatry, University of Wisconsin, 6001 Research Park Blvd, Madison, WI 53719, USA
    Sleep Med Rev 10:49-62. 2006
    This paper reviews a novel hypothesis about the functions of slow wave sleep-the synaptic homeostasis hypothesis...
  4. ncbi Memory of sequential experience in the hippocampus during slow wave sleep
    Albert K Lee
    Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 36:1183-94. 2002
    ..neurons repeatedly fired in precisely this order in long sequences involving four or more cells during slow wave sleep (SWS) immediately following, but not preceding, the experience...
  5. ncbi Hypothalamic regulation of sleep and circadian rhythms
    Clifford B Saper
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, USA
    Nature 437:1257-63. 2005
    ..the past decade has begun to identify the brain circuitry and neurotransmitters that regulate our daily cycles of sleep and wakefulness. The latter depends on a network of cell groups that activate the thalamus and the cerebral cortex...
  6. pmc Control of sleep and wakefulness
    Ritchie E Brown
    Laboratory of Neuroscience, VA Boston Healthcare System and Harvard Medical School, Brockton, Massachusetts 02301, USA
    Physiol Rev 92:1087-187. 2012
    This review summarizes the brain mechanisms controlling sleep and wakefulness. Wakefulness promoting systems cause low-voltage, fast activity in the electroencephalogram (EEG)...
  7. ncbi Breakdown of cortical effective connectivity during sleep
    Marcello Massimini
    Department of Psychiatry, University of Wisconsin, Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA
    Science 309:2228-32. 2005
    ..During non-rapid eye movement sleep, the initial response was stronger but was rapidly extinguished and did not propagate beyond the stimulation site...
  8. pmc Sleep state switching
    Clifford B Saper
    Department of Neurology, Program in Neuroscience, and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Neuron 68:1023-42. 2010
    We take for granted the ability to fall asleep or to snap out of sleep into wakefulness, but these changes in behavioral state require specific switching mechanisms in the brain that allow well-defined state transitions...
  9. ncbi Local sleep and learning
    Reto Huber
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin 53719, USA
    Nature 430:78-81. 2004
    Human sleep is a global state whose functions remain unclear. During much of sleep, cortical neurons undergo slow oscillations in membrane potential, which appear in electroencephalograms as slow wave activity (SWA) of <4 Hz...
  10. pmc About sleep's role in memory
    Björn Rasch
    Division of Biopsychology, Neuroscience Center Zurich, University of Zurich, Zurich, Switzerland
    Physiol Rev 93:681-766. 2013
    Over more than a century of research has established the fact that sleep benefits the retention of memory...
  11. pmc Sleep drives metabolite clearance from the adult brain
    Lulu Xie
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA
    Science 342:373-7. 2013
    The conservation of sleep across all animal species suggests that sleep serves a vital function. We here report that sleep has a critical function in ensuring metabolic homeostasis...
  12. pmc Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies
    Francesco P Cappuccio
    University of Warwick, Warwick Medical School, Clinical Sciences Research Institute, Coventry, UK
    Sleep 33:585-92. 2010
    Increasing evidence suggests an association between both short and long duration of habitual sleep with adverse health outcomes.
  13. ncbi Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan
    Maurice M Ohayon
    Stanford Sleep Epidemiology Research Center, School of Medicine, Stanford University, Palo Alto, CA 94303, USA
    Sleep 27:1255-73. 2004
    The purposes of this study were to identify age-related changes in objectively recorded sleep patterns across the human life span in healthy individuals and to clarify whether sleep latency and percentages of stage 1, stage 2, and rapid ..
  14. pmc Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index
    Shahrad Taheri
    Howard Hughes Medical Institute, Stanford University, Palo Alto, California, USA
    PLoS Med 1:e62. 2004
    b>Sleep duration may be an important regulator of body weight and metabolism. An association between short habitual sleep time and increased body mass index (BMI) has been reported in large population samples...
  15. ncbi Diurnal and seasonal mood vary with work, sleep, and daylength across diverse cultures
    Scott A Golder
    Department of Sociology, Cornell University, Ithaca, NY 14853, USA
    Science 333:1878-81. 2011
    ..individuals awaken in a good mood that deteriorates as the day progresses--which is consistent with the effects of sleep and circadian rhythm--and that seasonal change in baseline positive affect varies with change in daylength...
  16. ncbi Short and long sleep are positively associated with obesity, diabetes, hypertension, and cardiovascular disease among adults in the United States
    Orfeu M Buxton
    Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Division of Sleep Medicine, BLI 438, 221 Longwood Avenue, Boston, MA 02115, United States
    Soc Sci Med 71:1027-36. 2010
    Research associates short (and to a lesser extent long) sleep duration with obesity, diabetes, and cardiovascular disease; and although 7-8 h of sleep seems to confer the least health risk, these findings are often based on non-..
  17. pmc Self-reported and measured sleep duration: how similar are they?
    Diane S Lauderdale
    Department of Health Studies, University of Chicago, Chicago, Illinois 60637, USA
    Epidemiology 19:838-45. 2008
    Recent epidemiologic studies have found that self-reported duration of sleep is associated with obesity, diabetes, hypertension, and mortality...
  18. ncbi Sleep and synaptic homeostasis: a hypothesis
    Giulio Tononi
    Department of Psychiatry, University of Wisconsin, 6001 Research Park Blvd, Madison, WI 53719, USA
    Brain Res Bull 62:143-50. 2003
    During much of sleep, the cerebral cortex is rippled by slow waves, which appear in the electroencephalogram as oscillations between 0.5 and 4.5 Hz...
  19. pmc Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation
    Jason Rihel
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Science 327:348-51. 2010
    ..These results demonstrate the power of high-throughput behavioral profiling in zebrafish to discover and characterize psychotropic drugs and to dissect the pharmacology of complex behaviors...
  20. ncbi The role of actigraphy in the study of sleep and circadian rhythms
    Sonia Ancoli-Israel
    Department of Psychiatry, University of California, San Diego and Veterans Affairs San Diego Healthcare System, 92161, USA
    Sleep 26:342-92. 2003
    In summary, although actigraphy is not as accurate as PSG for determining some sleep measurements, studies are in general agreement that actigraphy, with its ability to record continuously for long time periods, is more reliable than ..
  21. pmc Sleep oscillations in the thalamocortical system induce long-term neuronal plasticity
    Sylvain Chauvette
    The Centre de Recherche Institut Universitaire en Santé Mentale de Québec CRIUSMQ, Laval University, Quebec, QC G1J 2G3, Canada
    Neuron 75:1105-13. 2012
    Long-term plasticity contributes to memory formation and sleep plays a critical role in memory consolidation...
  22. pmc Effect of short-term acclimatization to high altitude on sleep and nocturnal breathing
    Yvonne Nussbaumer-Ochsner
    Pulmonary Division and Sleep Disorders Center, University Hospital of Zurich, and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Sleep 35:419-23. 2012
    Objective physiologic data on sleep and nocturnal breathing at initial exposure and during acclimatization to high altitude are scant...
  23. pmc Quantity and quality of sleep and incidence of type 2 diabetes: a systematic review and meta-analysis
    Francesco P Cappuccio
    University of Warwick, Warwick Medical School, Clinical Sciences Research Institute, Coventry, UK
    Diabetes Care 33:414-20. 2010
    To assess the relationship between habitual sleep disturbances and the incidence of type 2 diabetes and to obtain an estimate of the risk.
  24. ncbi Correlates of sleep and waking in Drosophila melanogaster
    P J Shaw
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Science 287:1834-7. 2000
    Drosophila exhibits a circadian rest-activity cycle, but it is not known whether fly rest constitutes sleep or is mere inactivity...
  25. ncbi The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness
    Takeshi Sakurai
    Department of Pharmacology, Institute of Basic Medical Science, University of Tsukuba, Ibaraki 305 8575, Japan
    Nat Rev Neurosci 8:171-81. 2007
    b>Sleep and wakefulness are regulated to occur at appropriate times that are in accordance with our internal and external environments...
  26. ncbi Grouping of brain rhythms in corticothalamic systems
    M Steriade
    Laboratory of Neurophysiology, Laval University, Faculty of Medicine, Quebec, Canada G1K 7P4
    Neuroscience 137:1087-106. 2006
    ..This concept of unified brain rhythms does not only include low-frequency sleep oscillations but also fast (beta and gamma) activities that are not exclusively confined to brain-activated states,..
  27. ncbi Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation
    R M Chemelli
    Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, 75235 9050, USA
    Cell 98:437-51. 1999
    ..and send axons to numerous regions throughout the central nervous system, including the major nuclei implicated in sleep regulation...
  28. pmc Sleep and synaptic homeostasis: structural evidence in Drosophila
    Daniel Bushey
    Department of Psychiatry, University of Wisconsin, Madison, WI 53719, USA
    Science 332:1576-81. 2011
    The functions of sleep remain elusive, but a strong link exists between sleep need and neuronal plasticity...
  29. pmc Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle
    Jae Eun Kang
    Department of Neurology, Washington University, St Louis, MO 63110, USA
    Science 326:1005-7. 2009
    ..The amount of ISF Abeta also significantly increased during acute sleep deprivation and during orexin infusion, but decreased with infusion of a dual orexin receptor antagonist...
  30. ncbi Practice with sleep makes perfect: sleep-dependent motor skill learning
    Matthew P Walker
    Laboratory of Neurophysiology, Department of Psychiatry, Harvard Medical School, 74 Fenwood Road, Boston, Massachusetts 02115, USA
    Neuron 35:205-11. 2002
    ..Here we provide evidence that a night of sleep results in a 20% increase in motor speed without loss of accuracy, while an equivalent period of time during wake ..
  31. ncbi An ultra-sparse code underlies the generation of neural sequences in a songbird
    Richard H R Hahnloser
    Biological Computation Research Department, Bell Laboratories, Lucent Technologies, Murray Hill, New Jersey 07974, USA
    Nature 419:65-70. 2002
    ..RA), which generates stereotyped sequences of spike bursts during song and recapitulates these sequences during sleep. We show that the stereotyped sequences in RA are driven from nucleus HVC (high vocal centre), the principal pre-..
  32. ncbi Sleep-dependent memory consolidation
    Robert Stickgold
    Department of Psychiatry, Harvard Medical School, and Centre for Sleep and Cognition, Beth Israel Deaconess Medical Centre, 330 Brookline Avenue FD 861, Boston, Massachusetts 02215, USA
    Nature 437:1272-8. 2005
    The concept of 'sleeping on a problem' is familiar to most of us. But with myriad stages of sleep, forms of memory and processes of memory encoding and consolidation, sorting out how sleep contributes to memory has been anything but ..
  33. ncbi Neural substrates of awakening probed with optogenetic control of hypocretin neurons
    Antoine R Adamantidis
    Department of Psychiatry and Behavioral Sciences, Stanford University, 701B Welch Road, Palo Alto, California 94304, USA
    Nature 450:420-4. 2007
    The neural underpinnings of sleep involve interactions between sleep-promoting areas such as the anterior hypothalamus, and arousal systems located in the posterior hypothalamus, the basal forebrain and the brainstem...
  34. ncbi Diet promotes sleep duration and quality
    Katri Peuhkuri
    Institute of Biomedicine, Pharmacology, Medical Nutrition Physiology, University of Helsinki, Helsinki, Finland
    Nutr Res 32:309-19. 2012
    b>Sleep, much like eating, is an essential part of life. The mechanisms of sleep are only partially clear and are the subject of intense research. There is increasing evidence showing that sleep has an influence on dietary choices...
  35. pmc Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms
    D J Dijk
    Circadian, Neuroendocrine and Sleep Disorders Section, Division of Endocrinology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Physiol 516:611-27. 1999
    1. The circadian timing system has been implicated in age-related changes in sleep structure, timing and consolidation in humans. 2...
  36. ncbi The sleep slow oscillation as a traveling wave
    Marcello Massimini
    Department of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
    J Neurosci 24:6862-70. 2004
    During much of sleep, virtually all cortical neurons undergo a slow oscillation (<1 Hz) in membrane potential, cycling from a hyperpolarized state of silence to a depolarized state of intense firing...
  37. pmc Acute optogenetic silencing of orexin/hypocretin neurons induces slow-wave sleep in mice
    Tomomi Tsunematsu
    Division of Cell Signaling, National Institute for Physiological Sciences, Okazaki 444 8787, Japan
    J Neurosci 31:10529-39. 2011
    Orexin/hypocretin neurons have a crucial role in the regulation of sleep and wakefulness...
  38. pmc Sleep and synaptic renormalization: a computational study
    Umberto Olcese
    Perceptual Robots Laboratory, Scuola Superiore Sant Anna, Pisa, Italy
    J Neurophysiol 104:3476-93. 2010
    ..strength in cortical and other networks increases during wakefulness and returns to a baseline level during sleep. These homeostatic changes in synaptic strength are accompanied by corresponding changes in sleep slow wave ..
  39. ncbi Adenosine and sleep-wake regulation
    Radhika Basheer
    Neuroscience Laboratory, Department of Psychiatry, Harvard Medical School and Boston VA Healthcare System, Brockton, MA 02301, USA
    Prog Neurobiol 73:379-96. 2004
    This review addresses three principal questions about adenosine and sleep-wake regulation: (1) Is adenosine an endogenous sleep factor? (2) Are there specific brain regions/neuroanatomical targets and receptor subtypes through which ..
  40. ncbi Natural waking and sleep states: a view from inside neocortical neurons
    M Steriade
    Laboratoire de Neurophysiologie, Faculte de Medicine, Universite Laval, Quebec G1K 7P4, Canada
    J Neurophysiol 85:1969-85. 2001
    In this first intracellular study of neocortical activities during waking and sleep states, we hypothesized that synaptic activities during natural states of vigilance have a decisive impact on the observed electrophysiological ..
  41. ncbi A prospective study of sleep duration and coronary heart disease in women
    Najib T Ayas
    Division of Pulmonary Medicine, Department of Medicine, Vancouver General Hospital, 2775 Heather St, Vancouver, British Columbia, Canada V5Z 3J5
    Arch Intern Med 163:205-9. 2003
    Long-term sleep deprivation is common in today's society...
  42. pmc Adverse metabolic and cardiovascular consequences of circadian misalignment
    Frank A J L Scheer
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:4453-8. 2009
    ..mechanisms, we determined the effects of such misalignment between behavioral cycles (fasting/feeding and sleep/wake cycles) and endogenous circadian cycles on metabolic, autonomic, and endocrine predictors of obesity, ..
  43. ncbi Short sleep duration as a risk factor for hypertension: analyses of the first National Health and Nutrition Examination Survey
    James E Gangwisch
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Hypertension 47:833-9. 2006
    Depriving healthy subjects of sleep has been shown to acutely increase blood pressure and sympathetic nervous system activity...
  44. ncbi Practice parameters for clinical use of the multiple sleep latency test and the maintenance of wakefulness test
    Michael R Littner
    VA Greater Los Angeles Healthcare System, CA, USA
    Sleep 28:113-21. 2005
    Characterization of excessive sleepiness is an important task for the sleep clinician, and assessment requires a thorough history and in many cases, objective assessment in the sleep laboratory...
  45. ncbi The contribution of sleep to hippocampus-dependent memory consolidation
    Lisa Marshall
    University of Lubeck, Department of Neuroendocrinology, Haus 23a, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Trends Cogn Sci 11:442-50. 2007
    There is now compelling evidence that sleep promotes the long-term consolidation of declarative and procedural memories...
  46. pmc Sleep duration and cardiometabolic risk: a review of the epidemiologic evidence
    Kristen L Knutson
    Section of Pulmonary Critical Care, Department of Medicine, University of Chicago, 5841 S Maryland Ave MC 6076, Chicago, IL 60622, USA
    Best Pract Res Clin Endocrinol Metab 24:731-43. 2010
    Laboratory studies have found that short-term sleep restriction is associated with impairments in glucose metabolism, appetite regulation and blood pressure regulation...
  47. ncbi Comparison between subjective and actigraphic measurement of sleep and sleep rhythms
    S W Lockley
    School of Biological Sciences, University of Surrey, Guildford, UK
    J Sleep Res 8:175-83. 1999
    b>Sleep is often assessed in circadian rhythm studies and long-term monitoring is required to detect any changes in sleep over time...
  48. ncbi Social jetlag and obesity
    Till Roenneberg
    Institute for Medical Psychology, University of Munich, Munich, Germany
    Curr Biol 22:939-43. 2012
    ..Many factors converge to yield increased body mass index (BMI). Among these is sleep duration. The circadian clock controls sleep timing through the process of entrainment...
  49. ncbi Rest in Drosophila is a sleep-like state
    J C Hendricks
    Center for Sleep and Respiratory Neurobiology, School of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Neuron 25:129-38. 2000
    To facilitate the genetic study of sleep, we documented that rest behavior in Drosophila melanogaster is a sleep-like state...
  50. ncbi Boosting slow oscillations during sleep potentiates memory
    Lisa Marshall
    University of Lubeck, Department of Neuroendocrinology, Haus 23a, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Nature 444:610-3. 2006
    There is compelling evidence that sleep contributes to the long-term consolidation of new memories...
  51. pmc Circadian rhythms, sleep, and metabolism
    Wenyu Huang
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Clin Invest 121:2133-41. 2011
    ..brain and peripheral clocks and in determining how these interactions promote energy homeostasis across the sleep-wake cycle...
  52. pmc Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss
    Michael M Halassa
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuron 61:213-9. 2009
    ..of SNARE-dependent gliotransmission is the regulation of extracellular adenosine and because adenosine promotes sleep, we genetically inhibited the release of gliotransmitters and asked if astrocytes play an unsuspected role in ..
  53. pmc Cortical firing and sleep homeostasis
    Vladyslav V Vyazovskiy
    Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
    Neuron 63:865-78. 2009
    The need to sleep grows with the duration of wakefulness and dissipates with time spent asleep, a process called sleep homeostasis...
  54. ncbi Immune, inflammatory and cardiovascular consequences of sleep restriction and recovery
    Brice Faraut
    Sleep Laboratory, CHU de Charleroi, A Vésale Hospital, Montigny le Tilleul, Universite Libre de Bruxelles, Belgium
    Sleep Med Rev 16:137-49. 2012
    In addition to its effects on cognitive function, compelling evidence links sleep loss to alterations in the neuroendocrine, immune and inflammatory systems with potential negative public-health ramifications...
  55. ncbi Recent worldwide sleep patterns and problems during adolescence: a review and meta-analysis of age, region, and sleep
    Michael Gradisar
    School of Psychology, Flinders University, G P O Box 2100, Adelaide, 5001 South Australia, Australia
    Sleep Med 12:110-8. 2011
    Adolescent sleep health is becoming increasingly recognized internationally as a significant concern, with many countries reporting high incidences of sleep disturbance in our youth...
  56. pmc Sleep quality, arousal and pain thresholds in migraineurs: a blinded controlled polysomnographic study
    Morten Engstrøm
    Department of Clinical Neurosciences, Norwegian University of Science and Technology, Trondheim, N 7489, Norway
    J Headache Pain 14:12. 2013
    Our aim was to compare subjective and objective sleep quality and arousal in migraine and to evaluate the relationship between sleep quality and pain thresholds (PT) in controls, interictal, preictal and postictal migraine.
  57. ncbi The whats and whens of sleep-dependent memory consolidation
    Susanne Diekelmann
    University of Lubeck, Department of Neuroendocrinology, 23538 Lubeck, Germany
    Sleep Med Rev 13:309-21. 2009
    b>Sleep benefits memory consolidation. The reviewed studies indicate that this consolidating effect is not revealed under all circumstances but is linked to specific psychological conditions...
  58. ncbi Life between clocks: daily temporal patterns of human chronotypes
    Till Roenneberg
    Center for Chronobiology, Institute for Medical Psychology, Munich, Germany
    J Biol Rhythms 18:80-90. 2003
    ..the genetic basis of temporal organization in humans, the authors developed a questionnaire to document individual sleep times, self-reported light exposure, and self-assessed chronotype, considering work and free days separately...
  59. ncbi Association of usual sleep duration with hypertension: the Sleep Heart Health Study
    Daniel J Gottlieb
    The Pulmonary Center, Boston University School of Medicine, 715 Albany Street, R 304, Boston, MA 02118 2394, USA
    Sleep 29:1009-14. 2006
    Limited experimental data suggest that sleep restriction acutely elevates blood pressure; however, little is known about the relationship between usual sleep duration and hypertension...
  60. ncbi Sleep duration predicts cardiovascular outcomes: a systematic review and meta-analysis of prospective studies
    Francesco P Cappuccio
    Warwick Medical School, University of Warwick, CSB Building, UHCW Campus, Clifford Bridge Road, Coventry, UK
    Eur Heart J 32:1484-92. 2011
    Aims To assess the relationship between duration of sleep and morbidity and mortality from coronary heart disease (CHD), stroke, and total cardiovascular disease (CVD)...
  61. pmc Cyclic and sleep-like spontaneous alternations of brain state under urethane anaesthesia
    Elizabeth A Clement
    Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 3:e2004. 2008
    Although the induction of behavioural unconsciousness during sleep and general anaesthesia has been shown to involve overlapping brain mechanisms, sleep involves cyclic fluctuations between different brain states known as active (..
  62. pmc Inducing sleep by remote control facilitates memory consolidation in Drosophila
    Jeffrey M Donlea
    Department of Anatomy and Neurobiology, Washington University in St Louis, St Louis, MO 63110, USA
    Science 332:1571-6. 2011
    b>Sleep is believed to play an important role in memory consolidation...
  63. pmc Activation of cortical interneurons during sleep: an anatomical link to homeostatic sleep regulation?
    Thomas S Kilduff
    Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, CA 94025, USA
    Trends Neurosci 34:10-9. 2011
    Although slow wave activity in the EEG has been linked to homeostatic sleep regulation, the neurobiological substrate of sleep homeostasis is not well understood...
  64. ncbi Development of the brain's default mode network from wakefulness to slow wave sleep
    Philipp G Sämann
    Max Planck Institute of Psychiatry, Neuroimaging Research Group, 80804 Munich, Germany
    Cereb Cortex 21:2082-93. 2011
    ..Little is known on sleep-associated changes of spontaneously synchronized anatomical networks as detected by resting-state functional ..
  65. pmc Local sleep in awake rats
    Vladyslav V Vyazovskiy
    Department of Psychiatry, University of Wisconsin Madison, Madison, 6001 Research Park Boulevard, Wisconsin 53719, USA
    Nature 472:443-7. 2011
    ..During sleep, neurons oscillate between 'on' periods, when they fire as in an awake brain, and 'off' periods, when they stop ..
  66. ncbi PERIOD3, circadian phenotypes, and sleep homeostasis
    Derk Jan Dijk
    Surrey Sleep Research Centre, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XP, UK
    Sleep Med Rev 14:151-60. 2010
    Circadian rhythmicity and sleep homeostasis contribute to sleep phenotypes and sleep-wake disorders, some of the genetic determinants of which are emerging...
  67. ncbi Epidemiology of the human circadian clock
    Till Roenneberg
    Centre for Chronobiology, Institute for Medical Psychology, University of Munich, Goethestrasse 31, 80336 Munich, Germany
    Sleep Med Rev 11:429-38. 2007
    ..differences in organising their behaviour within the 24-h day-this is most obvious in their preferred timing of sleep and wakefulness...
  68. pmc Identification of SLEEPLESS, a sleep-promoting factor
    Kyunghee Koh
    Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 321:372-6. 2008
    b>Sleep is an essential process conserved from flies to humans. The importance of sleep is underscored by its tight homeostatic control. Through a forward genetic screen, we identified a gene, sleepless, required for sleep in Drosophila...
  69. pmc Sleep duration and sleep quality in relation to 12-year cardiovascular disease incidence: the MORGEN study
    Marieke P Hoevenaar-Blom
    Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Sleep 34:1487-92. 2011
    We studied sleep duration and sleep quality in relation to cardiovascular disease (CVD) incidence.
  70. ncbi Is sleep duration associated with childhood obesity? A systematic review and meta-analysis
    Xiaoli Chen
    Department of International Health, Center for Human Nutrition, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Obesity (Silver Spring) 16:265-74. 2008
  71. ncbi Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep
    Vladyslav V Vyazovskiy
    Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Blvd, Madison, Wisconsin 53719, USA
    Nat Neurosci 11:200-8. 2008
    ..For some memories, further consolidation requires sleep, but whether plastic processes during wakefulness and sleep differ is unclear...
  72. pmc Regional slow waves and spindles in human sleep
    Yuval Nir
    Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
    Neuron 70:153-69. 2011
    The most prominent EEG events in sleep are slow waves, reflecting a slow (<1 Hz) oscillation between up and down states in cortical neurons...
  73. ncbi Odor cues during slow-wave sleep prompt declarative memory consolidation
    Björn Rasch
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160 23a, 23538 Lubeck, Germany
    Science 315:1426-9. 2007
    b>Sleep facilitates memory consolidation. A widely held model assumes that this is because newly encoded memories undergo covert reactivation during sleep...
  74. ncbi Sleep selectively enhances memory expected to be of future relevance
    Ines Wilhelm
    Department of Neuroendocrinology, University of Lubeck, 23538 Lubeck, Germany
    J Neurosci 31:1563-9. 2011
    ..There is now compelling evidence that the long-term storage of memories preferentially occurs during sleep. However, the factors mediating the selectivity of sleep-associated memory consolidation are poorly understood...
  75. pmc Direct evidence for wake-related increases and sleep-related decreases in synaptic strength in rodent cortex
    Zhong Wu Liu
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 30:8671-5. 2010
    Despite evidence that waking is associated with net synaptic potentiation and sleep with depression, direct proof for changes in synaptic currents is lacking in large brain areas such as the cerebral cortex...
  76. pmc Sleep and the time course of motor skill learning
    Matthew P Walker
    Massachusetts Mental Health Center, Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02115, USA
    Learn Mem 10:275-84. 2003
    Growing evidence suggests that sleep plays an important role in the process of procedural learning. Most recently, sleep has been implicated in the continued development of motor-skill learning following initial acquisition...
  77. ncbi The influence of learning on sleep slow oscillations and associated spindles and ripples in humans and rats
    Matthias Mölle
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Eur J Neurosci 29:1071-81. 2009
    The mechanisms underlying off-line consolidation of memory during sleep are elusive...
  78. pmc Decoupling of the brain's default mode network during deep sleep
    Silvina G Horovitz
    Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:11376-81. 2009
    ..Here, by performing functional MRI in humans, it is shown that a natural, sleep-induced reduction of consciousness is reflected in altered correlation between DMN network components, most ..
  79. ncbi Sustained attention performance during sleep deprivation: evidence of state instability
    S M Doran
    Division of Sleep and Chronobiology, Department of Psychiatry, Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, 1013 Blockley Hall, 423 Guardian Drive, Philadelphia, Pennsylvania 19104, USA
    Arch Ital Biol 139:253-67. 2001
    Nathaniel Kleitman was the first to observe that sleep deprivation in humans did not eliminate the ability to perform neurobehavioral functions, but it did make it difficult to maintain stable performance for more than a few minutes...
  80. ncbi Cellular and network mechanisms of slow oscillatory activity (<1 Hz) and wave propagations in a cortical network model
    Albert Compte
    Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurophysiol 89:2707-25. 2003
    Slow oscillatory activity (<1 Hz) is observed in vivo in the cortex during slow-wave sleep or under anesthesia and in vitro when the bath solution is chosen to more closely mimic cerebrospinal fluid...
  81. ncbi Coordinated memory replay in the visual cortex and hippocampus during sleep
    Daoyun Ji
    The Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Neurosci 10:100-7. 2007
    b>Sleep replay of awake experience in the cortex and hippocampus has been proposed to be involved in memory consolidation...
  82. ncbi Sleep architecture changes during a trek from 1400 to 5000 m in the Nepal Himalaya
    Pamela L Johnson
    David Read Laboratory, Department of Medicine, University of Sydney, Sydney, NSW 2006, Australia
    J Sleep Res 19:148-56. 2010
    The aim of this study was to examine sleep architecture at high altitude and its relationship to periodic breathing during incremental increases in altitude...
  83. pmc Is insufficient quantity and quality of sleep a risk factor for neck, shoulder and low back pain? A longitudinal study among adolescents
    Juha P Auvinen
    Finnish Institute of Occupational Health, Aapistie 1, 90220 Oulu, Finland
    Eur Spine J 19:641-9. 2010
    The quantity and quality of adolescents' sleep may have changed due to new technologies. At the same time, the prevalence of neck, shoulder and low back pain has increased...
  84. ncbi The function of the sleep spindle: a physiological index of intelligence and a mechanism for sleep-dependent memory consolidation
    Stuart M Fogel
    University of Montreal, Montreal, Quebec, Canada, H3W 1W5
    Neurosci Biobehav Rev 35:1154-65. 2011
    ..the electrophysiological mechanisms involved in strengthening new memories into a more permanent form during sleep have been largely unknown...
  85. pmc Genetics of sleep and sleep disorders
    Amita Sehgal
    Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell 146:194-207. 2011
    b>Sleep remains one of the least understood phenomena in biology--even its role in synaptic plasticity remains debatable...
  86. ncbi Protein ingestion before sleep improves postexercise overnight recovery
    Peter T Res
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Med Sci Sports Exerc 44:1560-9. 2012
    ..We assessed the effect of protein ingestion immediately before sleep on digestion and absorption kinetics and protein metabolism during overnight recovery from a single bout of ..
  87. pmc Origin of active states in local neocortical networks during slow sleep oscillation
    Sylvain Chauvette
    Department of Psychiatry and Neuroscience, The Centre de Recherche Université Laval Robert Giffard CRULRG, Laval University, Quebec, PQ, Canada
    Cereb Cortex 20:2660-74. 2010
    Slow-wave sleep is characterized by spontaneous alternations of activity and silence in corticothalamic networks, but the causes of transition from silence to activity remain unknown...
  88. ncbi Cardiac activation during arousal in humans: further evidence for hierarchy in the arousal response
    E Sforza
    Laboratoire de Sommeil, Departement de Psychiatrie, Hopitaux Universitaires de Geneve, Geneve, Switzerland
    Clin Neurophysiol 111:1611-9. 2000
    One major subject of discussion in sleep studies is whether bursts of K-complexes (K-bursts) and delta waves (D-bursts), expressions of a subcortical arousal, truly reflect an arousal response during sleep...
  89. ncbi Effects of renal sympathetic denervation on blood pressure, sleep apnea course, and glycemic control in patients with resistant hypertension and sleep apnea
    Adam Witkowski
    Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland
    Hypertension 58:559-65. 2011
    ..We evaluated the effects of this procedure on BP and sleep apnea severity in patients with resistant hypertension and sleep apnea...
  90. pmc Gender-specific associations of short sleep duration with prevalent and incident hypertension: the Whitehall II Study
    Francesco P Cappuccio
    Clinical Sciences Research Institute, Warwick Medical School, Coventry, United Kingdom
    Hypertension 50:693-700. 2007
    b>Sleep deprivation (<or=5 hour per night) was associated with a higher risk of hypertension in middle-aged American adults but not among older individuals...
  91. pmc The cognitive cost of sleep lost
    John G McCoy
    VA Boston Healthcare System, Research Service and Harvard Medical School, Department of Psychiatry, 940 Belmont St, Brockton, MA 02301 5596, USA
    Neurobiol Learn Mem 96:564-82. 2011
    A substantial body of literature supports the intuitive notion that a good night's sleep can facilitate human cognitive performance the next day...
  92. ncbi The role and validity of actigraphy in sleep medicine: an update
    Avi Sadeh
    The Adler Center for Research in Child Development and Psychopathology, Department of Psychology, Tel Aviv University, Tel Aviv 69978, Israel
    Sleep Med Rev 15:259-67. 2011
    Activity-based sleep-wake monitoring or actigraphy has gained a central role as a sleep assessment tool in sleep medicine. It is used for sleep assessment in clinical sleep research, and as a diagnostic tool in sleep medicine...
  93. ncbi Effects of sleep and circadian rhythm on the human immune system
    Tanja Lange
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Ann N Y Acad Sci 1193:48-59. 2010
    ..These temporal changes originate from a combined influence of the circadian system and sleep. Both brain functions act synergistically and share neuroendocrine effector mechanisms to convey control over ..
  94. pmc Circadian system, sleep and endocrinology
    Christopher J Morris
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA, United States
    Mol Cell Endocrinol 349:91-104. 2012
    ..Levels of numerous hormones vary across the day and night. Such fluctuations are not only attributable to changes in sleep/wakefulness and other behaviors but also to a circadian timing system governed by the suprachiasmatic nucleus of ..
  95. ncbi A review of the evidence for P2 being an independent component process: age, sleep and modality
    Kate E Crowley
    Human Sleep Research Program, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Clin Neurophysiol 115:732-44. 2004
    ..the result of independent processes and highlights several features, such as its persistence from wakefulness into sleep, the general consensus that unlike most other EEG phenomena it increases with age, and the fact that it can be ..
  96. pmc Large-scale microelectrode recordings of high-frequency gamma oscillations in human cortex during sleep
    Michel Le Van Quyen
    Centre de Recherche de l Institut du Cerveau et de la Moelle Epinière INSERM Unité Mixte de Recherche en Santé 975 Centre National de la Recherche Scientifique Unité Mixte de Recherche 7225, Hopital de la Pitie Salpetriere, Paris, France
    J Neurosci 30:7770-82. 2010
    Gamma oscillations (40-120 Hz), usually associated with waking functions, can be recorded in the deepest stages of sleep in animals. The full details of their large-scale coordination across multiple cortical networks are still unknown...
  97. pmc Short sleep duration increases energy intakes but does not change energy expenditure in normal-weight individuals
    Marie Pierre St-Onge
    New York Obesity Research Center, St Luke s Roosevelt Hospital, New York, NY, USA
    Am J Clin Nutr 94:410-6. 2011
    Evidence suggests a relation between short sleep duration and obesity.
  98. pmc System consolidation of memory during sleep
    Jan Born
    Department of Medical Psychology and Neurobiology, University of Tubingen, Gartenstr 29, 72074, Tubingen, Germany
    Psychol Res 76:192-203. 2012
    Over the past two decades, research has accumulated compelling evidence that sleep supports the formation of long-term memory...
  99. ncbi The sleep switch: hypothalamic control of sleep and wakefulness
    C B Saper
    Dept of Neurology, Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Trends Neurosci 24:726-31. 2001
    More than 70 years ago, von Economo predicted a wake-promoting area in the posterior hypothalamus and a sleep-promoting region in the preoptic area. Recent studies have dramatically confirmed these predictions...
  100. pmc A video method to study Drosophila sleep
    John E Zimmerman
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, 125 South 31st St, Suite 2100, Philadelphia, PA 19104 3403, USA
    Sleep 31:1587-98. 2008
    To use video to determine the accuracy of the infrared beam-splitting method for measuring sleep in Drosophila and to determine the effect of time of day, sex, genotype, and age on sleep measurements.
  101. pmc Overnight therapy? The role of sleep in emotional brain processing
    Matthew P Walker
    Sleep and Neuroimaging Laboratory, Department of Psychology, University of California, Berkeley, California 94720 1650, USA
    Psychol Bull 135:731-48. 2009
    ..Within the biological sciences, a similar renaissance has taken place, focusing on the role of sleep in various neurocognitive processes and, most recently, on the interaction between sleep and emotional regulation...

Research Grants81

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  3. Cardiovascular Responses to Sleep Apnea in Tetraplegia: A Pilot Study
    Jill M Wecht; Fiscal Year: 2010
    ..provided by applicant): Screening studies suggest that the prevalence of moderate to severe obstructive sleep apnea (OSA) in persons with tetraplegia ranges from 22% to 36%, thus greatly exceeding prevalence estimates of 9...
  4. Hypothalamic Orexin Role in Menopause-Associated Hot Flashes and Mood/Sleep Disru
    PHILIP LEE JOHNSON; Fiscal Year: 2013
    ..that "the orexin system plays a critical role in menopause-related symptoms such as hot flashes, and mood/sleep disruption"...
  5. Autonomic, Endothelial, and Inflammatory Correlates of Sleep Duration
    MERCEDES RENEE CARNETHON; Fiscal Year: 2012
    Short sleep duration (<6 hours/night) is associated with a higher prevalence and incidence of hypertension, diabetes, and overweight/obesity, all of which can contribute to coronary heart disease...
  6. Brain mast cells and Chronic Fatigue Syndrome
    Theoharis C Theoharides; Fiscal Year: 2013
    ..CFS involves the nervous, hormonal and immune systems with symptoms that include fatigue, sleep disturbances, malaise, muscle aches, migraines, gastrointestinal complaints and cognitive problems...
  7. Effective treatment of sleep apnea in prediabetes to reduce cardiometabolic risk
    Esra Tasali; Fiscal Year: 2010
    ..Research and specific Challenge Topic, 04-HL-101: Identify Mechanisms Linking Cardiopulmonary Disease Risk and Sleep-Disordered Breathing. Diabetes is increasing in epidemic proportions in the U.S...
  8. ORGANIZATION OF CENTRAL SYMPATHETIC PATHWAYS
    Patrice G Guyenet; Fiscal Year: 2013
    ..provided by applicant): The neural mechanisms that automatically regulate breathing and the circulation during sleep reside primarily within the lower brainstem...
  9. Pituitary dysfunction, behavioral symptoms, and quality of life after blast mTBI
    CHARLES WILLIAM WILKINSON; Fiscal Year: 2012
    ..Impairment of memory and concentration, increased anxiety, irritability and mood instability, and sleep disturbance interfere with job and family relationships, producing substantial disability...
  10. Chronic nicotine and synaptic transmission in brainstem respiratory neurons
    RALPH FRANK FREGOSI; Fiscal Year: 2013
    ..offspring have a higher than normal incidence of impaired cardiac function, autonomic nervous system disorders, sleep disorders, delayed speech and central and obstructive apneas...
  11. Iron, Metabolic Regulation and Type 2 Diabetes Risk
    Donald A McClain; Fiscal Year: 2013
    ..We hypothesize that these effects may provide a mechanism that links the risks for diabetes engendered by altered sleep/wake cycles with those of excess dietary iron...
  12. Chronic Sleep Restriction Increases Immunity to Autoantigen: Role of the SNS
    Arnold E Postlethwaite; Fiscal Year: 2010
    ..RA), other chronic arthritides and other autoimmune diseases inflammatory or not, have partial chronic disrupted sleep. It is unknown what effect this partial chronic sleep disruption has on the immune mediated flares from new ..
  13. Adenosine and the Basal Forebrain in the Control of Behavioral State
    Robert E Strecker; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Many people reduce their sleep due to medical and non-medical reasons, a pattern that is called chronic sleep restriction (CSR)...
  14. ECG-derived cardiopulmonary coupling biomarkers of sleep, sleep-breathing, and ca
    Robert J Thomas; Fiscal Year: 2010
    ..The traditional approach to quantifying sleep and sleep-respiration relies on manual or computer assisted scoring of 30 second epochs, tagging of discrete fast ..
  15. Remote-control mouse-implantable micropumps for establishment of regenerative cap
    JUAN GABRIEL contact SANTIAGO; Fiscal Year: 2010
    ..These profiles will be automatically synchronized with mouse behaviors including exercise and sleep in the case of candidate MuSC regulators that are naturally synchronized with these behaviors, such as IGF-1...
  16. INTERNET ENHANCED HEALTH PROMOTION FOR OBESE ETHNIC MINORITY ADOLESCENTS
    Jessica A Whiteley; Fiscal Year: 2011
    ..are increasingly seen in obese youth, including insulin resistance, type 2 diabetes, hypertension, obstructive sleep apnea, poor self-esteem, lower health-related quality of life (Rashid &Roberts, 2000;Rosenbloom, 2002;Sorof, ..
  17. Epigenomic Events in Development of the Locus Coeruleus Noradrenergic Neurons
    Jan Krzysztof Blusztajn; Fiscal Year: 2012
    ..a critical component of the circuitry that is necessary for the processes of learning, memory, attention, sleep, arousal, anxiety, and responses to stress...
  18. Cerebral metabolism, EEG, and sleep cycling in critically ill neonates
    Renée A Shellhaas; Fiscal Year: 2013
    ..Key short-term goals include expansion of the PI's research to incorporate neonatal sleep physiology and complex signal analysis techniques, which will require additional mentorship and training...
  19. Respiratory and autonomic plasticity following intermittent hypoxia
    JASON HAROLD MATEIKA; Fiscal Year: 2012
    Abstract Approximately 8 % of the Veteran population in the United States suffers from sleep apnea. Consequences of untreated sleep apnea include increased daytime fatigue, hypertension and stroke...
  20. Pharmacologic Interventions for Cardiovascular Disease in Obstructive Sleep Apnea
    Barbara J Morgan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Obstructive sleep apnea (OSA), a relatively common condition that causes nightly exposure to intermittent hypoxia, has emerged as a risk factor for hypertension;however, the underlying mechanisms are ..
  21. SYSTEM FOR AUTOMATED NONINVASIVE MONITORING OF MOUSE SLEEP AND BEHAVIOR
    Sridhar Sunderam; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The basic functions of sleep are still unknown...
  22. Role of TPH2 and 5HT Neuronal Loss in Non-motor Symptoms of Parkinson's
    Donald M Kuhn; Fiscal Year: 2012
    ..the fact that approximately 80% of PD patients suffer from co-morbid neuropsychiatric conditions like depression, sleep disorders, anxiety and dementia. Many of these conditions have been linked to dysfunctional 5HT neurochemistry...
  23. Evaluation of obstructive sleep apnea with long range 3D endoscopic FDOCT
    Jun Zhang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Obstructive sleep apnea (OSA) is a major medical problem that affects 18-20 million people in the United States...
  24. The Impact of Obstructive Sleep Apnea on Non-Alcoholic Fatty Liver Disease
    KATHLEEN ELIZABETH COREY; Fiscal Year: 2013
    ..addition, her recent study assessing protective factors for the development of NAFLD, she found that obstructive sleep apnea (OSA) was one of the strongest predictors of normal liver histology in patients with obesity, suggesting ..
  25. Phenotyping Major Depression with Increased Inflammation
    Andrew H Miller; Fiscal Year: 2013
    ..given the association of early life stress, increased body mass index, treatment resistance and dysregulated sleep with inflammation, these factors will also be examined...
  26. Modulation of immune senescence by androgen treatment in aged male macaques
    Henryk F Urbanski; Fiscal Year: 2013
    ..AG-036670) that is investigating the impact of androgen supplementation on cognitive performance and circadian sleep-wake cycles in aged male macaques...
  27. Non-Alcoholic Fatty Liver Disease and Obstructive Sleep Apnea: Mechanistic Links
    SHIKHA SEKSARIA SUNDARAM; Fiscal Year: 2013
    ..Recent evidence indicates a potential link between NASH and obstructive sleep apnea (OSA), both common co-morbidities of obesity...
  28. Role of Dendritic Ca2+ Transients in Respiratory Rhythm Generation
    Jack L Feldman; Fiscal Year: 2010
    ..The failure to maintain a normal breathing rhythm in humans suffering from disorders such as sleep apnea, apnea of prematurity, congenital central hypoventilation syndrome, central alveolar hypo- ventilation ..
  29. The Impact of Sleep-Disordered Breathing on Adverse Pregnancy Outcomes
    LOUISE M O apos BRIEN; Fiscal Year: 2010
    ..One well recognized independent risk for hypertension is sleep-disordered breathing (SDB)...
  30. Design and Synthesis of Anxioselective Anxiolytics
    James M Cook; Fiscal Year: 2010
    ..The 1,4-benzodiazepines, employed to treat anxiety disorders as well as sleep disorders exhibit anxiolytic, anticonvulsant, muscle relaxant/ataxic, sedative- hypnotic and amnestic effects...
  31. Effects of brain-selective estradiol on gene expression and female sex behavior
    Kim Wallen; Fiscal Year: 2013
    ..symptoms associated with low levels or a lack of estrogens, including decreased sexual motivation, hot flushes, sleep disorders, depression/anxiety, brain and spinal cord trauma, amyotrophic lateral sclerosis, and cognitive ..
  32. The Role of Circadian Periodicity in Human Cardiovascular Disease and Diabetes
    John P Forman; Fiscal Year: 2013
    ..associations with CVD have not been reported, and potential interactions between circadian disruption (short sleep duration, rotating night shift work, snoring) and these variants have not been explored...
  33. Interacting Impact of Adrenal and Ovarian Aging on the CNS
    Henryk F Urbanski; Fiscal Year: 2011
    ..physiological processes such as cognition, learning, and attention, and leads to perturbation of the circadian sleep-wake cycle...
  34. Novel treatment of menopausal hot flushes with an estradiol prodrug
    Laszlo Prokai; Fiscal Year: 2012
    ..Hot flushes often negatively impact the quality of life of women because they are associated with sleep disturbances resulting in fatigue, depression, irritability, and forgetfulness, as well as acute physical ..
  35. BRAINSTEM MATURATION IN THE SUDDEN INFANT DEATH SYNDROME
    HANNAH CHASE KINNEY; Fiscal Year: 2013
    ..tryptophan hydroxylase (TPH2), in regions of the medulla oblongata that modulate cardiorespiratory function during sleep (the medullary 5-HT system) in four independent datasets...
  36. Pathophysiology and Animal Model of Restless Legs Syndrome (RLS): Btbd9 Null Mic
    Yuqing Li; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Restless legs syndrome (RLS) is a chronic sleep motor disorder characterized by unpleasant sensations in the legs and an uncontrollable urge to move them for relief...
  37. Mechanisms and Consequences of Intermittent Hypoxia-Induced Lipolysis
    Jonathan C Jun; Fiscal Year: 2013
    ..Jonathan Jun recently completed a 5-year fellowship at Johns Hopkins in Pulmonary, Critical Care, and Sleep Medicine. He has been working in the laboratory of Dr...
  38. Role of Subdiaphragmatic Vagus in Fibromyalgia Syndrome
    JON DAVID LEVINE; Fiscal Year: 2013
    ..HEALTH RELEVANCE: Fibromyalgia is characterized by widespread musculoskeletal pain and tenderness, disturbances in sleep, and co-occurrence of other generalized pain syndromes, such as irritable bowel syndrome and post-traumatic stress ..
  39. Masked Hypertension in Chronic Kidney Disease
    Rajiv Agarwal; Fiscal Year: 2013
    ..organ damage and mortality the magnitude of which will depend on how MHTN is defined;and 4) experience greater sleep disturbances, reduced day-time physical activity, increased body fat, and greater exercise-induced increased BP...
  40. EEG Synchrony, perinatal risk and outcome: analysis of CHIME data
    PHILIP GEORGE GRIEVE; Fiscal Year: 2010
    ..hypotheses relating risk information to quantitative measures of EEG power, synchrony and nonlinear coupling to sleep state, and neurodevelopmental outcome...
  41. Connexins in Neuronal and Glial Gap Junctions in the Central Nervous System
    John E Rash; Fiscal Year: 2012
    ..the high-frequency neuronal oscillatory synchronizations that are thought to underlie consciousness, arousal from sleep, cognition, associative binding for learning and memory, and fine motor control, and which become pathologically ..
  42. RidCancerPain Intervention in a Hispanic Population Along the US-Mexico Border
    KRISTYNIA MARIE contact ROBINSON; Fiscal Year: 2010
    ..the likelihood of minorities suffering from the costly consequences of uncontrolled pain such as depression, sleep disorders, lost work productivity, and impaired relationships with family and friends (American Pain Foundation, ..
  43. Predictors of sleep-dependent Memory Consolidation in Obstructive Sleep Apnea
    Ina E Djonlagic; Fiscal Year: 2013
    Dr. Ina Djonlagic is a board-certified neurologist and sleep specialist. She is an associate physician at Brigham and Women's Hospital and an Instructor in Medicine at Harvard Medical School...
  44. Prevalence and Impact of Frailty among Dialysis Patients
    Kirsten L Johansen; Fiscal Year: 2013
    ..Finally, we hypothesize that frailty is associated with depressed mood, post-dialysis fatigue, and sleep disturbance, all of which negatively affect quality of life in this population...
  45. Postpartum Depression: Role of Sleep &Genetic Risk in Postpartum Mood Disorders
    Katherine M Sharkey; Fiscal Year: 2013
    ..The candidate, Katherine M. Sharkey, MD, PhD, is a physician-scientist with a multidisciplinary background of sleep and circadian rhythms research and clinical training in psychiatry, internal medicine, and sleep medicine...
  46. Melanin-Concentrating Hormone: Ancestral Role in Feeding &Sleep Regulation
    Philippe Mourrain; Fiscal Year: 2013
    ..In mammals, melanin-concentrating hormone (hMCH) is a key regulator of feeding behavior, energy homeostasis, and sleep. MCH was first identified in salmon in 1983 as a peptide (sMCH) that induced skin lightening...
  47. Progesterone's Role in Pubertal Maturation in Normal and Hyperandrogenemic Adoles
    JESSICAH S P COLLINS; Fiscal Year: 2011
    ..this process may be altered in the setting of HA;and (c) how differential control of GnRH frequency depending on sleep status may explain observed patterns of GnRH secretion in girls with and without HA...
  48. Daily Experience in Adolescence and Biomarkers of Early Risk for Adult Health
    Andrew J Fuligni; Fiscal Year: 2013
    ..Daily experiences such as social conflict, excessive demands, emotional distress, threat, and sleep behaviors have been shown to be linked to both global risk factors and multiple biological indices of health risk ..
  49. Discovery of Selective MT1 Melatonin Receptor Ligands for Sleep Disorders
    Margarita L Dubocovich; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Sleep disorders due to stress, illness, chronic pain, and poor sleep habits are a major social and health concern, resulting in lost work, decreased attention and productivity, daytime drowsiness, ..
  50. Race-based social stress and health trajectories from adolescence to adulthood
    Jacquelynne S Eccles; Fiscal Year: 2010
    ..basal functioning of multiple physiological systems (endocrine, cardiovascular, metabolic, immune, inflammatory, sleep) reflecting well-established risk factors for a variety of poor health outcomes;(2) the acute reactivity and ..
  51. Oxygen versus PAP for treatment of sleep apnea in chronic heart failure
    Henry Klar Yaggi; Fiscal Year: 2013
    ..Central sleep apnea (CSA) is a common comorbid condition, with moderate to severe CSA present in approximately one-third of ..
  52. A Pilot Study of Yoga for Breathing and Quality of Life of Lung Cancer Patients
    JUDITH MARIE FOULADBAKHSH; Fiscal Year: 2013
    ..Fear and anxiety is further intensified due to respiratory compromise, increasing stress, and impairing sleep and mood...
  53. Modeling schizophrenia gamma deficits using cell-specific RNAi knockdown of GAD67
    RITCHIE EDWARD BROWN; Fiscal Year: 2012
    ..we propose to use RNA interference (RNAi), building on our previous experience using this technique in the sleep field...
  54. Inducible recombination and gene expression in specific neurotransmitter systems
    Steven A Thomas; Fiscal Year: 2012
    ..system is highly relevant to the understanding of fundamental neurophysiological and behavioral processes such as sleep, arousal and attention, motivation and reward, and learning and memory, as well as disorders related to these ..
  55. Melanopsin Signal Transduction Studied by FTIR Spectroscopy
    Kenneth J Rothschild; Fiscal Year: 2012
    ..Because melanopsin is involved in a variety of physiological functions including sleep, mental alertness, eating habits, and hormonal levels, as well potentially involved in a variety of disorders ..
  56. The upper airway and the Sudden Infant Death Syndrome
    Donald Bartlett; Fiscal Year: 2012
    ..We will also study intact, chronically instrumented piglets during wakefulness, NREM and REM sleep to determine the combined influence on the LCR of hyperthermia and manipulation of central nervous system ..
  57. Extending Sleep in Obese Adults to Promote Weight Loss
    Ann E Rogers; Fiscal Year: 2010
    ..use of central heating and air conditioning, increasing gravid age, decreased smoking rates, and decreased sleep durations. Sleep loss due to voluntary curtailment of sleep is common among Americans of all ages...
  58. STRAW+10: Addressing the Unfinished Agenda of Staging Reproductive Aging - RESUBM
    Sioban D Harlow; Fiscal Year: 2011
    ..loss of fertility, increased bone resorption, change in lipid profiles and temporal increases in symptoms, sleep disturbances and depression...
  59. Mechanisms and consequences of sleep disordered breathing in COPD
    Cynthia D Brown; Fiscal Year: 2012
    ..Her specific area of interest is in sleep disorders in chronic lung disease, and the period of time covered by the career development award is important for ..
  60. A Functional Role for the Circadian Clock Protein Per1 in the Regulation of ??ENa
    Michelle L Gumz; Fiscal Year: 2013
    ..Many physiological processes exhibit a circadian pattern, including the sleep-wake cycle, heart beat, hormone secretion, renal blood flow, and blood pressure...
  61. CHOLINERGIC MECHANISMS OF REM SLEEP GENERATION
    Helen A Baghdoyan; Fiscal Year: 2013
    ..Acetylcholine (ACh) plays a key role in generating the rapid eye movement (REM) phase of sleep, and REM sleep abnormalities typify some forms of depression...
  62. Perinatal Assessment of At-Risk Populations
    William P Fifer; Fiscal Year: 2013
    ..In these studies we propose to incorporate more direct measures of CNS maturation during sleep, as well as more sophisticated analyses of autonomic nervous system regulation in both the fetus and infant in ..
  63. Sleep in Rats: From Conceptualization to Measurement, Analysis and Interpretation
    Gayle Giboney Page; Fiscal Year: 2010
    ..preclinical models to study biobehavioral susceptibility to the development of persistent pain, findings that (1) sleep restriction increases susceptibility to hind paw mechanical hypersensitivity in both controls and animals with ..
  64. Stimulation Induced Modulation of Sleep
    MATTHEW TARLER; Fiscal Year: 2009
    ..levels produces major changes in respiratory drive, of special importance to the control of ventilation during sleep. The carotid bodies are critical for ventilatory acclimatization to high altitude, and contribute in part to ..
  65. Sleep Patterns and Depression in Mothers and Fathers of Twins
    ELIZABETH DAMATO; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Sleep Patterns and Depression in Mothers and Fathers of Twins The demands of early parenthood and their impact on the ability to obtain rest and sleep are exponentially high for parents ..
  66. Neurobiology of PTSD During REM Sleep
    Anne Germain; Fiscal Year: 2010
    ..disorder (PTSD) is a debilitating and often chronic mental disorder that adversely affects daytime functioning and sleep during and after military deployment...
  67. SLEEP ACADEMIC AWARD--RECOGNITION OF SLEEP DISORDERS
    Kingman Strohl; Fiscal Year: 2002
    The goals of this SLEEP ACADEMIC AWARD are to implement and assess a knowledge system for sleep and sleep disorders...
  68. Nighttime Acoustic Pharyngometer (NAP) for Airway Obstruction Identification
    HANI KAYYALI; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The ability to define the location of airway obstructions in Obstructive Sleep Apnea (OSA) patients is critical for surgical and oral appliance treatments because these therapies target the ..
  69. Feasibility of Measuring Sleep in a Critical Care Environment
    Margaret A Pisani; Fiscal Year: 2010
    b>Sleep is an essential biological function that has physiological, behavioral and temporal characteristics. It is regulated by homeostatic and circadian processes...
  70. Nurses' Health Study: Short Sleep Duration and Risk of Hypertension
    JAMES GANGWISCH; Fiscal Year: 2009
    Short sleep duration has been shown to be associated with an increased risk for hypertension incidence, but previous prospective studies on this association did not examine the potential effect modifiers of menopausal status, hormone ..
  71. 2012 Pineal Cell Biology Gordon Research ConferenceLinks to circadian clocks, sl
    Vincent M Cassone; Fiscal Year: 2011
    ..biochemical pathways linking the pineal gland and its hormone melatonin with the circadian clock timing system, sleep/wake processing and metabolism...
  72. ELECTROPHYSIOLOGY & PHARMACOLOGY OF SLEEP-WAKEFULNESS
    Mahesh Thakkar; Fiscal Year: 2004
    ..of this program of research is to understand the physiological and pharmacological mechanisms controlling sleep, both the REM and nonREM phases, and thereby provide a sound basis for the understanding and treatment of human ..
  73. MEASURING QOL DURING TREATMENT FOR SLEEP APNEA
    JEANNETTE BREUGELMANS; Fiscal Year: 2000
    The objective of this study is to examine the relative importance of acquiring health status information on a sleep apnea patient's functioning and quality of life by partners as proxy raters...
  74. SLEEP INFLUENCE ON THE PHARYNX AND VENTILATORY CONTROL
    Clifford Zwillich; Fiscal Year: 1993
    Obstructive sleep apnea is a disorder whose pathogenesis remains poorly understood...
  75. Development of Automated Noninvasive DiskTreadmills for Sleep Deprivation in Mice
    Jidong Fang; Fiscal Year: 2007
    ..Project Summary-Abstract Modern societies face a mounting epidemic that cuts across all age groups: daily sleep loss. Cumulative sleep loss induces excessive daytime sleepiness and impairs cognitive performance...
  76. Sleep in Cardiac patients with Implantable Cardioverter Defibrillators (ICD)
    CHRISTINA MCCRAE; Fiscal Year: 2009
    ..b>Sleep disturbance represents a significant comorbidity for ~57 percent of ICD patients, potentially contributing to a ..
  77. Circadian rhythm genes and sleep disturbances in the elderly
    Gregory J Tranah; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Sleep disorders among the elderly are pervasive, yet frequently undiagnosed and untreated...
  78. Promoting Sleep Health in Pediatric Primary Care Settings: A Web-based CME Course
    Lisa Marceau; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The 2006 IOM Report states that poor sleep is an unmet public health problem and that, "cumulative long- term effects of sleep loss and sleep disorders have been associated with a wide range of ..
  79. Blue-White Light Therapy for Circadian Sleep Disorders in Alzheimer's Disease
    Philip Sloane; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Disturbed night-time sleep is common in older persons with Alzheimer's disease and related dementias (ADRD), leading to significant negative effects on the daytime function of the affected ..
  80. Sleep Therapy Headset for Improving Sleep Quality of Older Adults
    PHILIP BONELLO; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Chronic sleep disturbances are experienced by 40% to 70% of the oldest people in the population, over 65 years...
  81. MOLECULAR REGULATION OF ADENOSINE IN RELATION TO SLEEP
    Miroslaw Mackiewicz; Fiscal Year: 2000
    Among the sleep promoting compounds already identified is adenosine. Agonists of adenosine increase sleep, while antagonists decrease it. Extracellular levels of adenosine change across the sleep/wake cycle...