visual acuity

Summary

Summary: Acuteness or clearness of vision, especially of form vision, which is dependent mainly on the sharpness of the retinal focus.

Top Publications

  1. ncbi Ranibizumab for neovascular age-related macular degeneration
    Philip J Rosenfeld
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    N Engl J Med 355:1419-31. 2006
  2. ncbi Retinitis pigmentosa
    Dyonne T Hartong
    Ocular Molecular Genetics Institute, Harvard Medical School, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    Lancet 368:1795-809. 2006
  3. ncbi Development of the 25-item National Eye Institute Visual Function Questionnaire
    C M Mangione
    Division of General Internal Medicine and Health Services Research, Department of Medicine, UCLA, 911 Broxton Plaza, Box 951736, Los Angeles, CA 90095-1736, USA
    Arch Ophthalmol 119:1050-8. 2001
  4. doi Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER Study year 1
    Carl D Regillo
    Retina Service, Wills Eye Institute, 840 Walnut Street, Philadelphia, PA 19107, USA
    Am J Ophthalmol 145:239-248. 2008
  5. doi A variable-dosing regimen with intravitreal ranibizumab for neovascular age-related macular degeneration: year 2 of the PrONTO Study
    Geeta A Lalwani
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Am J Ophthalmol 148:43-58.e1. 2009
  6. doi Two-year outcomes of the ranibizumab for edema of the mAcula in diabetes (READ-2) study
    Quan Dong Nguyen
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 117:2146-51. 2010
  7. pmc A randomized trial comparing the efficacy and safety of intravitreal triamcinolone with standard care to treat vision loss associated with macular Edema secondary to branch retinal vein occlusion: the Standard Care vs Corticosteroid for Retinal Vein Occlu
    Ingrid U Scott
    EMMES Corporation, Rockville, MD 20850, USA
    Arch Ophthalmol 127:1115-28. 2009
  8. pmc Global magnitude of visual impairment caused by uncorrected refractive errors in 2004
    Serge Resnikoff
    Chronic Disease Prevention and Management, WHO, Geneva, Switzerland
    Bull World Health Organ 86:63-70. 2008
  9. doi Effects of lutein supplementation on macular pigment optical density and visual acuity in patients with age-related macular degeneration
    Günther Weigert
    Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
    Invest Ophthalmol Vis Sci 52:8174-8. 2011
  10. ncbi Pegaptanib for neovascular age-related macular degeneration
    Evangelos S Gragoudas
    Retina Service, Massachusetts Eye and Ear Infirmary and Harvard Medical School, 243 Charles St, Boston, MA 02114, USA
    N Engl J Med 351:2805-16. 2004

Detail Information

Publications329 found, 100 shown here

  1. ncbi Ranibizumab for neovascular age-related macular degeneration
    Philip J Rosenfeld
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    N Engl J Med 355:1419-31. 2006
    ..Ranibizumab--a recombinant, humanized, monoclonal antibody Fab that neutralizes all active forms of vascular endothelial growth factor A--has been evaluated for the treatment of neovascular age-related macular degeneration...
  2. ncbi Retinitis pigmentosa
    Dyonne T Hartong
    Ocular Molecular Genetics Institute, Harvard Medical School, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    Lancet 368:1795-809. 2006
    ..is diminished generally many years before symptomic night blindness, visual-field scotomas, or decreased visual acuity arise. More than 45 genes for retinitis pigmentosa have been identified...
  3. ncbi Development of the 25-item National Eye Institute Visual Function Questionnaire
    C M Mangione
    Division of General Internal Medicine and Health Services Research, Department of Medicine, UCLA, 911 Broxton Plaza, Box 951736, Los Angeles, CA 90095-1736, USA
    Arch Ophthalmol 119:1050-8. 2001
    ..correlations between the NEI VFQ-25 subscales that have the most to do with central vision and measured visual acuity. CONCLUSIONS: The reliability and validity of the NEI VFQ-25 are comparable to those of the 51-item NEI VFQ ..
  4. doi Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER Study year 1
    Carl D Regillo
    Retina Service, Wills Eye Institute, 840 Walnut Street, Philadelphia, PA 19107, USA
    Am J Ophthalmol 145:239-248. 2008
    ..To evaluate the efficacy and safety of ranibizumab administered monthly for three months and then quarterly in patients with subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD)...
  5. doi A variable-dosing regimen with intravitreal ranibizumab for neovascular age-related macular degeneration: year 2 of the PrONTO Study
    Geeta A Lalwani
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Am J Ophthalmol 148:43-58.e1. 2009
    ....
  6. doi Two-year outcomes of the ranibizumab for edema of the mAcula in diabetes (READ-2) study
    Quan Dong Nguyen
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 117:2146-51. 2010
    ..To determine the long-term effects of ranibizumab (RBZ) in patients with diabetic macular edema (DME)...
  7. pmc A randomized trial comparing the efficacy and safety of intravitreal triamcinolone with standard care to treat vision loss associated with macular Edema secondary to branch retinal vein occlusion: the Standard Care vs Corticosteroid for Retinal Vein Occlu
    Ingrid U Scott
    EMMES Corporation, Rockville, MD 20850, USA
    Arch Ophthalmol 127:1115-28. 2009
    ....
  8. pmc Global magnitude of visual impairment caused by uncorrected refractive errors in 2004
    Serge Resnikoff
    Chronic Disease Prevention and Management, WHO, Geneva, Switzerland
    Bull World Health Organ 86:63-70. 2008
    ..The estimates were based on the prevalence of visual acuity of less than 6/18 in the better eye with the currently available refractive correction that could be improved ..
  9. doi Effects of lutein supplementation on macular pigment optical density and visual acuity in patients with age-related macular degeneration
    Günther Weigert
    Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
    Invest Ophthalmol Vis Sci 52:8174-8. 2011
    ..In addition, an investigation was conducted into whether lutein supplementation improves visual acuity (VA) and macular function (mean differential light threshold; MDLT), as assessed with microperimetry.
  10. ncbi Pegaptanib for neovascular age-related macular degeneration
    Evangelos S Gragoudas
    Retina Service, Massachusetts Eye and Ear Infirmary and Harvard Medical School, 243 Charles St, Boston, MA 02114, USA
    N Engl J Med 351:2805-16. 2004
    ..Pegaptanib, an anti-vascular endothelial growth factor therapy, was evaluated in the treatment of neovascular age-related macular degeneration...
  11. doi The utility of using customized heterochromatic flicker photometry (cHFP) to measure macular pigment in patients with age-related macular degeneration
    J M Stringham
    Vision Science Laboratory, University of Georgia, Athens, GA, USA
    Exp Eye Res 87:445-53. 2008
    ..Most of the patients were in AREDS category 2 (27%) or 3 (57%). Patients with visual acuity as poor as 20/80 were included, and could perform the task as long as they could see the stimulus...
  12. ncbi Refractive error and visual impairment in urban children in southern china
    Mingguang He
    Zhongshan Ophthalmic Center, Guangzhou, People s Republic of China
    Invest Ophthalmol Vis Sci 45:793-9. 2004
    ..To assess the prevalence of refractive error and visual impairment in school-age children in a metropolitan area of southern China...
  13. doi A prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (BOLT study) 12-month data: report 2
    Michel Michaelides
    Department of Medical Retina, Moorfields Eye Hospital, London, United Kingdom
    Ophthalmology 117:1078-1086.e2. 2010
    ....
  14. doi Sustained benefits from ranibizumab for macular edema following branch retinal vein occlusion: 12-month outcomes of a phase III study
    David M Brown
    Retinal Consultants of Houston, Houston, Texas, USA
    Ophthalmology 118:1594-602. 2011
    ..Assess 12-month efficacy and safety of intraocular injections of 0.3 mg or 0.5 mg ranibizumab in patients with macular edema after branch retinal vein occlusion (BRVO)...
  15. pmc Expanded 2-year follow-up of ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema
    Michael J Elman
    Elman Retina Group, PA, Baltimore, Maryland, USA
    Ophthalmology 118:609-14. 2011
    ..5 mg ranibizumab or 4 mg triamcinolone combined with focal/grid laser compared with focal/grid laser alone for treatment of diabetic macular edema (DME)...
  16. pmc Findings from a rapid assessment of avoidable blindness (RAAB) in Southern Malawi
    Khumbo Kalua
    Department of Ophthalmology, College of Medicine, University of Malawi, Blantyre, Malawi
    PLoS ONE 6:e19226. 2011
    ..The purpose of this study was to determine the prevalence and causes of blindness in persons aged 50 and above in southern Malawi to plan eye care services for the community...
  17. doi The prevalence of blindness and cataract surgery in rautahat district, Nepal
    Yuddha D Sapkota
    Nepal Netra Jyoti Sangh, Tripureshwor, Kathmandu, Nepal
    Ophthalmic Epidemiol 17:82-9. 2010
    ..This study aimed to ascertain the impact of the hospital services by estimating the prevalence of blindness, visual impairment and cataract surgical coverage among the older adult population of the Rautahat district...
  18. ncbi Correcting keratoconus with intracorneal rings
    J Colin
    Brest University Hospital, Brest, France
    J Cataract Refract Surg 26:1117-22. 2000
    ..To evaluate the potential of intrastromal corneal ring technology (Intacs, KeraVision) to correct keratoconus without central corneal scarring...
  19. doi Correlation between visual acuity and foveal microstructural changes in diabetic macular edema
    Tomohiro Otani
    Department of Ophthalmology, Gunma University School of Medicine, Maebashi, Gunma, Japan
    Retina 30:774-80. 2010
    The purpose of this study was to investigate the correlation between best-corrected visual acuity and foveal microstructural changes of the external limiting membrane and the junction between the inner and outer segments of the ..
  20. doi Primary End Point (Six Months) Results of the Ranibizumab for Edema of the mAcula in diabetes (READ-2) study
    Quan Dong Nguyen
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9277, USA
    Ophthalmology 116:2175-81.e1. 2009
    ..To compare ranibizumab with focal/grid laser or a combination of both in diabetic macular edema (DME)...
  21. pmc Factors associated with visual acuity outcomes after vitrectomy for diabetic macular edema: diabetic retinopathy clinical research network
    Christina J Flaxel
    Oregon Health and Science University, Portland, Oregon, USA
    Retina 30:1488-95. 2010
    ..To evaluate factors ¶associated with favorable outcomes after vitrectomy for diabetic macular edema...
  22. doi Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: Two-year results of the ANCHOR study
    David M Brown
    Vitreoretinal Consultants, Methodist Hospital, Houston, Texas 77030, USA
    Ophthalmology 116:57-65.e5. 2009
    ....
  23. doi Descemet's stripping endothelial keratoplasty: safety and outcomes: a report by the American Academy of Ophthalmology
    W Barry Lee
    Eye Consultants of Atlanta, 3225 Cumberland Boulevard, Atlanta, GA 30339, USA
    Ophthalmology 116:1818-30. 2009
    ..To review the published literature on safety and outcomes of Descemet's stripping endothelial keratoplasty (DSEK) for the surgical treatment of endothelial diseases of the cornea...
  24. ncbi Angiographic and optical coherence tomographic results of the MARINA study of ranibizumab in neovascular age-related macular degeneration
    Peter K Kaiser
    Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Ophthalmology 114:1868-75. 2007
    ....
  25. pmc A randomized trial comparing the efficacy and safety of intravitreal triamcinolone with observation to treat vision loss associated with macular edema secondary to central retinal vein occlusion: the Standard Care vs Corticosteroid for Retinal Vein Occlus
    Michael S Ip
    EMMES Corporation, Rockville, MD 20850, USA
    Arch Ophthalmol 127:1101-14. 2009
    ..To compare the efficacy and safety of 1-mg and 4-mg doses of preservative-free intravitreal triamcinolone with observation for eyes with vision loss associated with macular edema secondary to perfused central retinal vein occlusion (CRVO)...
  26. doi Inner segment/outer segment junction assessed by spectral-domain optical coherence tomography in patients with idiopathic epiretinal membrane
    Maiko Inoue
    Department of Ophthalmology, Yokohama City University Medical Center, Yokohama, Japan
    Am J Ophthalmol 150:834-9. 2010
    ....
  27. doi High-resolution imaging of the photoreceptor layer in epiretinal membrane using adaptive optics scanning laser ophthalmoscopy
    Sotaro Ooto
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Ophthalmology 118:873-81. 2011
    ....
  28. ncbi Descemet's stripping with endothelial keratoplasty in 50 eyes: a refractive neutral corneal transplant
    Francis W Price
    Price Vision Group, 9002 N Meridian St, Ste 100, Indianapolis, IN 46260, USA
    J Refract Surg 21:339-45. 2005
    ..To evaluate early visual and refractive outcomes following treatment of corneal endothelial dysfunction with a corneal transplantation technique, Descemet's stripping with endothelial keratoplasty (DSEK)...
  29. ncbi Primary vitrectomy for rhegmatogenous retinal detachment: an analysis of 512 cases
    Heinrich Heimann
    St Paul s Eye Unit, Royal Liverpool University Hospital, UK
    Graefes Arch Clin Exp Ophthalmol 244:69-78. 2006
    ..However, the surgical procedure is still flawed by a significant rate of anatomical and functional failures. The study was conducted to analyse the risk factors for a dissatisfying postoperative outcome...
  30. doi Intacs implantation using a femtosecond laser for management of keratoconus: Comparison of 306 cases in different stages
    Aylin Ertan
    Kudret Eye Hospital, Kennedy Caddesi No 71, Kavaklidere, Ankara, Turkey
    J Cataract Refract Surg 34:1521-6. 2008
    ..To evaluate the efficacy of intrastromal ring segment (Intacs, Addition Technology, Inc.) implantation and analyze outcomes according to different keratoconus stages...
  31. ncbi A phase II randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema
    Emmett T Cunningham
    Stanford University, USA
    Ophthalmology 112:1747-57. 2005
    ..To evaluate the safety and efficacy of pegaptanib sodium injection (pegaptanib) in the treatment of diabetic macular edema (DME)...
  32. pmc Randomized trial evaluating short-term effects of intravitreal ranibizumab or triamcinolone acetonide on macular edema after focal/grid laser for diabetic macular edema in eyes also receiving panretinal photocoagulation
    Joseph Googe
    Southeastern Retina Associates, P C, Knoxville, Tennessee, USA
    Retina 31:1009-27. 2011
    ..To evaluate 14-week effects of intravitreal ranibizumab or triamcinolone in eyes receiving focal/grid laser for diabetic macular edema and panretinal photocoagulation...
  33. ncbi Macular perfusion determined by fundus fluorescein angiography at the 4-month time point in a prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (Bolt Study): Report 1
    Michel Michaelides
    Department of Medical Retina, Moorfields Eye Hospital, London, UK
    Retina 30:781-6. 2010
    ....
  34. ncbi Morphological and functional retinal impairment in Alzheimer's disease patients
    V Parisi
    Clinica Oculistica Università di Roma Tor Vergata, Rome, Italy
    Clin Neurophysiol 112:1860-7. 2001
    ....
  35. doi Foveal microstructure and visual acuity after retinal detachment repair: imaging analysis by Fourier-domain optical coherence tomography
    Taku Wakabayashi
    Department of Ophthalmology, Osaka University Medical School, Suita, Osaka, Japan
    Ophthalmology 116:519-28. 2009
    ..To evaluate foveal microstructural changes in eyes with anatomically successful repair of rhegmatogenous retinal detachments (RRDs)...
  36. pmc Safety and efficacy of gene transfer for Leber's congenital amaurosis
    Albert M Maguire
    Scheie Eye Institute, University of Pennsylvania, USA
    N Engl J Med 358:2240-8. 2008
    ..hRPE65v2. Each patient had a modest improvement in measures of retinal function on subjective tests of visual acuity. In one patient, an asymptomatic macular hole developed, and although the occurrence was considered to be an ..
  37. doi Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: long-term results
    Frederik Raiskup-Wolf
    Department of Ophthalmology, C G Carus University Hospital, Dresden, Germany
    J Cataract Refract Surg 34:796-801. 2008
    ..To prove the long-term dampening effect of riboflavin- and ultraviolet-A-induced collagen crosslinking on progressive keratoconus...
  38. ncbi The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma
    Michael A Kass
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Ophthalmol 120:701-13; discussion 829-30. 2002
    ..There is no consensus on the efficacy of medical treatment in delaying or preventing the onset of POAG in individuals with elevated IOP. Therefore, we designed a randomized clinical trial, the Ocular Hypertension Treatment Study...
  39. ncbi The natural history and prognosis of neovascular age-related macular degeneration: a systematic review of the literature and meta-analysis
    Tien Y Wong
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
    Ophthalmology 115:116-26. 2008
    ..To describe the natural history and progression of visual loss in eyes with untreated neovascular age-related macular degeneration (AMD)...
  40. ncbi Correlation between CFH Y402H and HTRA1 rs11200638 genotype to typical exudative age-related macular degeneration and polypoidal choroidal vasculopathy phenotype in the Japanese population
    Norimoto Gotoh
    Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, Japan
    Clin Experiment Ophthalmol 36:437-42. 2008
    ....
  41. doi Complement factor H and high-temperature requirement A-1 genotypes and treatment response of age-related macular degeneration
    Takashi Tsuchihashi
    Department of Ophthalmology, Saitama Medical University, Iruma, Saitama, Japan
    Ophthalmology 118:93-100. 2011
    ....
  42. doi Treatment patterns, visual acuity and quality-of-life outcomes of the WAVE study - a noninterventional study of ranibizumab treatment for neovascular age-related macular degeneration in Germany
    Robert P Finger
    Department of Ophthalmology, University of Bonn, Germany
    Acta Ophthalmol 91:540-6. 2013
    ..To evaluate effectiveness, tolerability and safety of repeated intravitreal injections of 0.5 mg ranibizumab for the treatment of neovascular age-related macular degeneration in routine medical practice in Germany...
  43. ncbi Polypoidal choroidal vasculopathy: incidence, demographic features, and clinical characteristics
    Kenichiro Sho
    Department of Ophthalmology, Kansai Medical University, Fumizono cho, Moriguchi, Osaka, Japan
    Arch Ophthalmol 121:1392-6. 2003
    ..To clarify the incidence, demographic features, and clinical characteristics of polypoidal choroidal vasculopathy (PCV) in Japanese patients...
  44. doi Visual acuity is reduced in alpha 7 nicotinic receptor knockout mice
    Nicola Origlia
    Neuroscience Institute National Council of Research CNR, Pisa, Italy
    Invest Ophthalmol Vis Sci 53:1211-8. 2012
    ..The impact of α7 homomeric nAChRs on visual function was investigated using mutant mice lacking the α7 nicotinic receptor subunit...
  45. doi Impairment of contrast visual acuity as a functional correlate of retinal nerve fibre layer thinning and total macular volume reduction in multiple sclerosis
    Markus Bock
    NeuroCure Clinical Research Center, Charite Universitatsmedizin Berlin, Charitplatz 1, 10117 Berlin, Germany
    Br J Ophthalmol 96:62-7. 2012
    ....
  46. ncbi Patterns of diabetic macular edema with optical coherence tomography
    T Otani
    Department of Ophthalmology, Gunma University School of Medicine, Maebashi, Japan
    Am J Ophthalmol 127:688-93. 1999
    We report cross-sectional images of diabetic macular edema and correlation between tomographic features and visual acuity with best correction by means of optical coherence tomography.
  47. ncbi Ranibizumab versus verteporfin for neovascular age-related macular degeneration
    David M Brown
    Vitreoretinal Consultants, Methodist Hospital, Houston, TX 77030, USA
    N Engl J Med 355:1432-44. 2006
    ....
  48. doi Effect of gene therapy on visual function in Leber's congenital amaurosis
    James W B Bainbridge
    Institute of Ophthalmology, University College London, London, United Kingdom
    N Engl J Med 358:2231-9. 2008
    ..There were no serious adverse events. There was no clinically significant change in visual acuity or in peripheral visual fields on Goldmann perimetry in any of the three patients...
  49. pmc The transition zone between healthy and diseased retina in patients with retinitis pigmentosa
    Donald C Hood
    Department of Psychology, ColumbiaUniversity, New York, NY, USA
    Invest Ophthalmol Vis Sci 52:101-8. 2011
    ..To describe the structural changes in the transition zone from relatively healthy retinal regions to severely affected regions in patients with retinitis pigmentosa (RP) using frequency domain optical coherence tomography (fdOCT)...
  50. ncbi INTACS inserts for treating keratoconus: one-year results
    J Colin
    Bordeaux University Hospital, Hopital Pellegrin, Bordeaux, France
    Ophthalmology 108:1409-14. 2001
    ..MAIN OUTCOME MEASURES: Differences between preoperative and postoperative uncorrected visual acuity, best spectacle-corrected visual acuity, manifest refraction, and keratometry values were statistically ..
  51. ncbi Comparison of single-segment and double-segment Intacs for keratoconus and post-LASIK ectasia
    Munish Sharma
    Boxer Wachler Vision Institute, 465 North Roxbury Drive, Beverly Hills, CA 90210, USA
    Am J Ophthalmol 141:891-5. 2006
    ..To evaluate the efficacy of single-segment Intacs and compare with double-segment Intacs in subjects with post-LASIK ectasia and keratoconus...
  52. doi Photoreceptor inner/outer segment defect imaging by spectral domain OCT and visual prognosis after macular hole surgery
    Jaeryung Oh
    Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, Florida
    Invest Ophthalmol Vis Sci 51:1651-8. 2010
    ..To evaluate photoreceptor inner/outer segment (IS/OS) defect parameters by using spectral domain-optical coherence tomography (SD-OCT) for correlation with visual outcomes in macular hole surgery (MHS)...
  53. pmc Relationship between optical coherence tomography-measured central retinal thickness and visual acuity in diabetic macular edema
    David J Browning
    Jaeb Center for Health Research, 15310 Amberly Drive, Suite 350, Tampa, FL 33647, USA
    Ophthalmology 114:525-36. 2007
    To compare optical coherence tomography (OCT)-measured retinal thickness and visual acuity in eyes with diabetic macular edema (DME) both before and after macular laser photocoagulation.
  54. ncbi The association of multiple visual impairments with self-reported visual disability: SEE project
    G S Rubin
    Lions Vision Center, Department of Biostatistics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Invest Ophthalmol Vis Sci 42:64-72. 2001
    ..This report examines the relationship between psychophysical measures of visual impairment and self-reported difficulty with everyday visual tasks in a population-based sample of individuals 65 years of age and older...
  55. doi Association between high-risk disease loci and response to anti-vascular endothelial growth factor treatment for wet age-related macular degeneration
    Anton Orlin
    Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Retina 32:4-9. 2012
    ....
  56. doi CFH, VEGF and HTRA1 promoter genotype may influence the response to intravitreal ranibizumab therapy for neovascular age-related macular degeneration
    Martin McKibbin
    Eye Clinic, St James s University Hospital, Leeds LS9 7TF, UK
    Br J Ophthalmol 96:208-12. 2012
    ....
  57. doi Functional-morphologic correlates in patients with branch retinal vein occlusion and macular edema
    Hidetaka Noma
    Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women s Medical University, Owada shinden, Yachiyo, Chiba, Japan
    Retina 31:2102-8. 2011
    To investigate the relations among best-corrected visual acuity, retinal sensitivity, retinal thickness, and retinal volume in patients with branch retinal vein occlusion, and macular edema.
  58. ncbi Small-incision iris fixation of foldable intraocular lenses in the absence of capsule support
    Garry P Condon
    Drexel University College of Medicine, Pittsburgh, Pennsylvania, USA
    Ophthalmology 114:1311-8. 2007
    ..To report visual outcomes and complications of modified McCannel iris suture fixation of small-incision foldable acrylic intraocular lenses (IOLs) for aphakia in the absence of capsule support...
  59. doi Prevalence and vision-related outcomes of cataract surgery in Gujarat, India
    Gudlavalleti V S Murthy
    International Center for Eye Health, London School of Hygiene and Tropical Medicine, London, UK
    Ophthalmic Epidemiol 16:400-9. 2009
    ..Investigate the prevalence and vision-related outcomes of cataract surgery in an area of high cataract surgical rate...
  60. doi Retrospective contralateral study comparing descemet stripping automated endothelial keratoplasty with penetrating keratoplasty
    Irit Bahar
    Department of Ophthalmology, Toronto Western Hospital, Ontario, Canada
    Cornea 28:485-8. 2009
    ....
  61. ncbi Acute-onset endophthalmitis after clear corneal cataract surgery (1996-2005). Clinical features, causative organisms, and visual acuity outcomes
    Geeta A Lalwani
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Ophthalmology 115:473-6. 2008
    To report the clinical features, causative organisms, and visual acuity outcomes associated with endophthalmitis after clear corneal cataract surgery and to compare outcomes with those of the Endophthalmitis Vitrectomy Study (EVS).
  62. doi Prevalence of blindness and visual impairment in Nigeria: the National Blindness and Visual Impairment Study
    Fatima Kyari
    National Eye Centre, Kaduna, Nigeria
    Invest Ophthalmol Vis Sci 50:2033-9. 2009
    ..To determine the prevalence of blindness and visual impairment among adults aged > or = 40 years in Nigeria...
  63. pmc The association of age-related maculopathy susceptibility 2 polymorphisms with phenotype in typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy
    Hiroaki Bessho
    Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan
    Mol Vis 17:977-82. 2011
    ....
  64. ncbi Postoperative complications associated with 25-gauge pars plana vitrectomy
    Omesh P I Gupta
    Retina Service, Wills Eye at Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Ophthalmic Surg Lasers Imaging 38:270-5. 2007
    ..To report postoperative complications in eyes undergoing 25-gauge pars plana vitrectomy (PPV)...
  65. ncbi Macular grid photocoagulation after intravitreal triamcinolone acetonide for diffuse diabetic macular edema
    Se Woong Kang
    Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135 710, Korea
    Arch Ophthalmol 124:653-8. 2006
    ..To evaluate the clinical outcomes of macular laser photocoagulation after the intravitreal injection of 4 mg of triamcinolone acetonide (IVTA) for diffuse diabetic macular edema (DME)...
  66. doi Intravitreal Avastin for macular oedema secondary to retinal vein occlusion: a prospective study
    K Kriechbaum
    University Eye Hospital Zurich, Frauenklinikstrasse 24, CH 8091 Zurich, Switzerland
    Br J Ophthalmol 92:518-22. 2008
    ..To evaluate efficacy and safety of intravitreal bevacizumab (Avastin) in eyes with macular oedema secondary to central retinal vein occlusion (CRVO) or branch retinal vein occlusion (BRVO)...
  67. doi Natural course and funduscopic findings of polypoidal choroidal vasculopathy in a Japanese population over 1 year of follow-up
    Hiroaki Bessho
    Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan
    Retina 31:1598-602. 2011
    ..To evaluate the natural course and possible funduscopic risk factors for polypoidal choroidal vasculopathy in a Japanese population...
  68. pmc NrCAM deletion causes topographic mistargeting of thalamocortical axons to the visual cortex and disrupts visual acuity
    Galina P Demyanenko
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    J Neurosci 31:1545-58. 2011
    ..zone of primary visual cortex (V1), particularly when evoked from the ipsilateral eye, indicating abnormal visual acuity and ocularity...
  69. doi Short-term outcomes of 23-gauge pars plana vitrectomy
    Omesh P Gupta
    Retina Service, Wills Eye Institute, Jefferson Medical College, Philadelphia, Pennsylvania, USA
    Am J Ophthalmol 146:193-197. 2008
    ..To report the initial experience and safety profile of 23-gauge pars plana vitrectomy (PPV) in eyes undergoing vitreoretinal surgery...
  70. ncbi Rapid assessment of avoidable blindness in Kunming, china
    Min Wu
    Red Cross Hospital, Kunming, Yunnan, China
    Ophthalmology 115:969-74. 2008
    ....
  71. ncbi Biometry and formula accuracy with intraocular lenses used for cataract surgery in extreme hyperopia
    Robert E MacLaren
    Moorfields Eye Hospital, City Road, London, United Kingdom
    Am J Ophthalmol 143:920-931. 2007
    ..To audit intraocular lens (IOL) power predictions for cataract surgery in extreme hyperopia and to compare the accuracy across different biometry formulae and IOL types...
  72. doi Safety and efficacy of a flexible dosing regimen of ranibizumab in neovascular age-related macular degeneration: the SUSTAIN study
    Frank G Holz
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Ophthalmology 118:663-71. 2011
    ..To evaluate the safety and efficacy of individualized ranibizumab treatment in patients with neovascular age-related macular degeneration...
  73. ncbi Ranibizumab for predominantly classic neovascular age-related macular degeneration: subgroup analysis of first-year ANCHOR results
    Peter K Kaiser
    Cole Eye Institute, Cleveland, OH 44195, USA
    Am J Ophthalmol 144:850-857. 2007
    ..classic choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) were retrospectively analyzed to identify patient and disease characteristics that may predict visual acuity (VA) treatment outcomes.
  74. ncbi Refractive error and visual impairment in school-age children in Gombak District, Malaysia
    Pik Pin Goh
    Department of Ophthalmology, Hospital Selayang, Selangor, Malaysia
    Ophthalmology 112:678-85. 2005
    ..To assess the prevalence of refractive error and visual impairment in school-age children in Gombak District, a suburban area near Kuala Lumpur city...
  75. doi Intravitreal bevacizumab (Avastin) for macular oedema secondary to retinal vein occlusion: 12-month results of a prospective clinical trial
    F Prager
    Department of Ophthalmology, Medical University of Vienna, Waehringer Guertel 18 20, 1190 Wien, Austria
    Br J Ophthalmol 93:452-6. 2009
    ....
  76. pmc A phase II randomized clinical trial of intravitreal bevacizumab for diabetic macular edema
    Ingrid U Scott
    Jaeb Center for Health Research, 15310 Amberly Drive, Suite 350, Tampa, FL 33647, USA
    Ophthalmology 114:1860-7. 2007
    ..To provide data on the short-term effect of intravitreal bevacizumab for diabetic macular edema (DME)...
  77. ncbi Behavioral assessment of visual acuity in mice and rats
    G T Prusky
    Department of Psychology and Neuroscience, The University of Lethbridge, 4401 University Drive, AB, TIK 3M4, Lethbridge, Canada
    Vision Res 40:2201-9. 2000
    ..Both mice and rats learn the task quickly. Performance falls below 70% when the spatial frequency is increased beyond 0.5 cycles in most C57BU6 mice, and around 1.0 cycles per degree (cpd) in Long-Evans rats...
  78. pmc Pharmacogenetics of complement factor H (Y402H) and treatment of exudative age-related macular degeneration with ranibizumab
    A Y Lee
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Br J Ophthalmol 93:610-3. 2009
    ..To determine whether complement factor H (CFH) genotypes have a pharmacogenetic effect on the treatment of exudative age-related macular degeneration (AMD) with ranibizumab...
  79. ncbi Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration
    Napoleone Ferrara
    Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Retina 26:859-70. 2006
    ..Among these, ranibizumab is a high affinity recombinant Fab that neutralizes all isoforms of VEGF-A. The article briefly reviews the biology of VEGF and then focuses on the path that led to clinical development of ranibizumab...
  80. doi Foldable toric intraocular lens for astigmatism correction in cataract patients
    Javier Mendicute
    Ophthalmology Service, Donostia Hospital, Po Dr Begiristáin 115, San Sebastian, Spain
    J Cataract Refract Surg 34:601-7. 2008
    ..To evaluate the results of AcrySof toric intraocular lens (IOL) (Alcon) implantation to correct preexisting astigmatism in patients having cataract surgery...
  81. doi Evaluation of injection frequency and visual acuity outcomes for ranibizumab monotherapy in exudative age-related macular degeneration
    Hajir Dadgostar
    Cole Eye Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Ophthalmology 116:1740-7. 2009
    ....
  82. pmc Visual acuity measures do not reliably detect childhood refractive error--an epidemiological study
    Lisa O'Donoghue
    School of Biomedical Sciences, University of Ulster, Coleraine, N Ireland, United Kingdom
    PLoS ONE 7:e34441. 2012
    To investigate the utility of uncorrected visual acuity measures in screening for refractive error in white school children aged 6-7-years and 12-13-years.
  83. doi Results of one-year's treatment with ranibizumab for exudative age-related macular degeneration in a clinical setting
    Salomon Y Cohen
    Centre Ophtalmologique d Imagerie et de Laser, Assistance Publique Hôpitaux de Paris and Université Paris 7, France
    Am J Ophthalmol 148:409-13. 2009
    ..To evaluate the results of 1 year of treatment with intravitreal ranibizumab for exudative age-related macular degeneration (AMD) in a clinical setting...
  84. doi The significance of external limiting membrane status for visual acuity in age-related macular degeneration
    Akio Oishi
    Department of Ophthalmology, Kobe City Medical Center General Hospital, Japan
    Am J Ophthalmol 150:27-32.e1. 2010
    To evaluate status of the external limiting membrane (ELM) as a contributor of visual acuity (VA) in age-related macular degeneration (AMD).
  85. ncbi Causes and prevalence of visual impairment among adults in the United States
    Nathan Congdon
    Wilmer Eye Institute, Wilmer 120, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Arch Ophthalmol 122:477-85. 2004
    ..To estimate the cause-specific prevalence and distribution of blindness and low vision in the United States by age, race/ethnicity, and gender, and to estimate the change in these prevalence figures over the next 20 years...
  86. ncbi Monocular versus binocular visual acuity as measures of vision impairment and predictors of visual disability
    G S Rubin
    Lions Vision Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Invest Ophthalmol Vis Sci 41:3327-34. 2000
    ..To examine the relationship between monocular and binocular visual acuities as predictors of visual disability in a population-based sample of individuals 65 years of age and older...
  87. doi The SECURE study: long-term safety of ranibizumab 0.5 mg in neovascular age-related macular degeneration
    Rufino Silva
    Department of Ophthalmology, Coimbra University Hospital, Faculty of Medicine, University of Coimbra, and Association for Innovation and Biomedical Research on Light and Image AIBILI, Coimbra, Portugal
    Ophthalmology 120:130-9. 2013
    ..To evaluate long-term safety of intravitreal ranibizumab 0.5-mg injections in neovascular age-related macular degeneration (nAMD)...
  88. ncbi Evaluating a new logMAR chart designed to improve visual acuity assessment in population-based surveys
    R R A Bourne
    Department of Epidemiology and International Eye Health Institute of Ophthalmology University College London UK
    Eye (Lond) 17:754-8. 2003
    This study aimed to evaluate a new chart designed to improve the collection of visual acuity data in population-based surveys...
  89. ncbi How sensitive to clinical change are ETDRS logMAR visual acuity measurements?
    Daniel A Rosser
    Institute of Ophthalmology, University College London, London, United Kingdom
    Invest Ophthalmol Vis Sci 44:3278-81. 2003
    ..test-retest variability (TRV) data are used to determine whether measured changes in ETDRS logarithm of the minimum angle of resolution (logMAR) visual acuity reflect true clinical change or are attributable to measurement error alone.
  90. doi Association between photoreceptor integrity and visual outcome in diabetic macular edema
    Hyun Jin Shin
    Department of Ophthalmology, Konkuk University Medical Center, Konkuk University School of Medicine, 4 12 Hwayang dong, Gwangjin gu, Seoul 143 729, Republic of Korea
    Graefes Arch Clin Exp Ophthalmol 250:61-70. 2012
    To investigate the correlation between foveal photoreceptor integrity and final visual acuity (VA) after treatment of eyes with diabetic macular edema (DME), and to determine the visual prognostic factors.
  91. doi The prevalence of glaucoma in adult rural Chinese populations of the Bai nationality in Dali: the Yunnan Minority Eye Study
    Hua Zhong
    First Affiliated Hospital of Kunming Medical University, Kunming, China
    Invest Ophthalmol Vis Sci 53:3221-5. 2012
    ..We evaluated the prevalence of glaucoma in adults of the Bai Nationality populations in rural China...
  92. doi Choroidal thickness, vascular hyperpermeability, and complement factor H in age-related macular degeneration and polypoidal choroidal vasculopathy
    Pichai Jirarattanasopa
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Invest Ophthalmol Vis Sci 53:3663-72. 2012
    ....
  93. doi Correlation of visual recovery and presence of photoreceptor inner/outer segment junction in optical coherence images after successful macular hole repair
    Takayuki Baba
    Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, Japan
    Retina 28:453-8. 2008
    To determine the relationship between the postoperative visual acuity (VA) and the presence of a photoreceptor inner segment (IS) and outer segment (OS) junction (IS/OS) in optical coherence tomographic (OCT) images after macular hole (..
  94. pmc Changing trends in the prevalence of blindness and visual impairment in a rural district of India: systematic observations over a decade
    Rohit C Khanna
    Allen Foster Community Eye Health Research Centre, International Centre for Advancement of Rural Eye care Prof Brien Holden Eye Research Centre, L V Prasad Eye Institute, LV Prasad Marg, Road No 2, Banjarahills, Hyderabad, India
    Indian J Ophthalmol 60:492-7. 2012
    ..3%; 95% CI, 13.5-21.8%) compared with APEDS (34%; 95% CI, 20.9-49.3%). Conclusion : There was a significant reduction in prevalence of blindness and VI in this rural district of India over a decade...
  95. ncbi Visual acuities "hand motion" and "counting fingers" can be quantified with the freiburg visual acuity test
    Kilian Schulze-Bonsel
    Department of Ophthalmology, University of Freiburg, Freiburg, Germany
    Invest Ophthalmol Vis Sci 47:1236-40. 2006
    The visual acuity (VA) of patients with very low vision is classified using the semiquantitative scale "counting fingers" (CF), "hand motion" (HM), "light perception" (LP), and "no light perception...
  96. doi The clinical efficacy of a topical dorzolamide in the management of cystoid macular edema in patients with retinitis pigmentosa
    Yasuhiro Ikeda
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Graefes Arch Clin Exp Ophthalmol 250:809-14. 2012
    ..of retinitis pigmentosa (RP), and is responsible for patient complications such as blurred and reduced visual acuity and for subsequent atrophic changes in the fovea...
  97. doi Novel method for analyzing snellen visual acuity measurements
    Ninel Z Gregori
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Retina 30:1046-50. 2010
    Most retrospective reviews convert Snellen visual acuity measurements obtained during routine clinic visits to logarithm of the minimum angle of resolution (logMAR) units so that statistical manipulations can be performed...
  98. pmc The effect of cone opsin mutations on retinal structure and the integrity of the photoreceptor mosaic
    Joseph Carroll
    Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Invest Ophthalmol Vis Sci 53:8006-15. 2012
    ..To evaluate retinal structure and photoreceptor mosaic integrity in subjects with OPN1LW and OPN1MW mutations...
  99. doi Rapid assessment of avoidable blindness and cataract surgical services in kilimanjaro region, Tanzania
    Celestin Habiyakire
    Kilimanjaro Christian Medical College, Tumaini University, Tanzania
    Ophthalmic Epidemiol 17:90-4. 2010
    ..To estimate the prevalence and causes of avoidable blindness and visual impairment in persons 50 years of age and older, and to assess the impact of cataract surgical services...
  100. doi One-year results of three monthly ranibizumab injections and as-needed reinjections for polypoidal choroidal vasculopathy in Japanese patients
    Taiichi Hikichi
    Ohtsuka Eye Hospital, Sapporo, Japan
    Am J Ophthalmol 154:117-124.e1. 2012
    ..To investigate the 1-year outcomes of monthly intravitreal injections of ranibizumab for 3 months followed by an as-needed reinjection schedule to treat polypoidal choroidal vasculopathy (PCV) in Japanese patients...
  101. ncbi One-year outcomes of photodynamic therapy in age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese patients
    Fumi Gomi
    Department of Ophthalmology, Osaka University Medical School, Suita, Osaka, Japan
    Ophthalmology 115:141-6. 2008
    ....

Research Grants79

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..To learn whether CNTF can improve visual acuity or color vision, and whether it may reduce sensitivity to light in people with CNGB3 achromatopsia...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..To learn whether CNTF can improve visual acuity or color vision, and whether it may reduce sensitivity to light in people with CNGB3 achromatopsia...
  3. A reconstructed skin model for development of treatments for albinism
    Seth J Orlow; Fiscal Year: 2010
    ..In addition to loss of visual acuity, greatly increased risk of skin cancers and substantial psychosocial burdens associated with a highly visible ..
  4. Optic Nerve Aging and Glaucoma
    Thasarat Vajaranant; Fiscal Year: 2013
    ..Glaucoma-related visual loss, even in the presence of normal visual acuity, can lead to significant functional visual impairment and substantial secondary risks to health including ..
  5. Familial and Birth Cohort Effects on the Aging Senses
    Karen J Cruickshanks; Fiscal Year: 2013
    ..and dichotic listening tests, distortion product otoacoustic emissions), eye examination (refraction, visual acuity measures, contrast sensitivity, and digital images of the lens and retina), olfaction testing (San Diego Odor ..
  6. Differentiation of Cord Blood Mesenchymal Stem Cells to Corneal Endothelium
    Nancy C Joyce; Fiscal Year: 2010
    ..of corneal disease by providing a new, healthy source of HCEC-like cells to treat patients who have lost visual acuity due to dysfunction of this physiologically important tissue...
  7. Epidemiology of Retinopathy and other Complications in Long Term Type 1 Diabetes
    Michael Y Tsai; Fiscal Year: 2013
    ..of retinopathy from stereoscopic fundus photography combined with a standardized grading, refraction and visual acuity, carotid artery ultrasound, electrocardiogram, measurement of skin intrinsic fluorescence, tests of cognition, ..
  8. Regulated Transgene Expression in the Retina
    James M Wilson; Fiscal Year: 2010
    ..Diseases that affect visual acuity have emerged as potential candidates for gene therapy...
  9. Pathogensis of Bacterial corneal infection
    Gerald B Pier; Fiscal Year: 2013
    ..and elaborate a large armamentarium of virulence factors that contribute to corneal damage and loss of visual acuity. Therapies for these infections need to both reduce bacterial numbers and allow the host to have an adequate ..
  10. African and European Descent, Ocular Blood Flow and Glaucoma Progression
    Alon Harris; Fiscal Year: 2013
    ..underwent comprehensive testing including: multiple measures of intraocular pressure (Goldmann and Psacal), visual acuity, contrast sensitivity, ultrasonic corneal pachymetry of central corneal thickness, height, weight, body mass ..
  11. Chinese American Eye Study
    Rohit Varma; Fiscal Year: 2013
    ..older, will be invited to undergo an interview and a comprehensive eye examination, including measurement of visual acuity, visual field, intraocular pressure, hemoglobin A1c, blood glucose, and serum C-reactive protein;additional ..
  12. Vestibular rehabilitation and dizziness in geriatric patients
    Courtney Hall; Fiscal Year: 2012
    ..and percent of time that dizziness interferes with activities;4) disability;5) balance-related confidence;6) visual acuity during head movement as a measure of gaze stability;7) dynamic gait index as a measure of fall risk;8) ..
  13. Phase 2 Study of High Dose DHA for the Treatment of X-Linked Retinitis Pigmentosa
    Dennis R Hoffman; Fiscal Year: 2013
    ..flicker as the primary functional outcome, rod ERGs, a-wave rod and cone ERG photoreceptor assessment, visual acuity, visual fields, fundus photography, dark-adapted thresholds, ocular coherence tomography (OCT) and ..
  14. Genetic Basis of Nanophthalmos and Human Ocular Biometry
    Olof H Sundin; Fiscal Year: 2010
    ..4 to 16.3 mm, relative to the population average of 23.5 mm. Lens-corrected visual acuity varies from 20/20 to 20/200, and physiological tests demonstrate that this gene is not essential for the basic ..
  15. MICROTUBULE-BASED TRANSPORT IN LACRIMAL GLAND FUNCTION
    Sarah F Hamm-Alvarez; Fiscal Year: 2012
    ..released by these cells is associated with keratoconjunctivitis sicca (KCS), which can severely compromise visual acuity. KCS can occur with the systemic autoimmune disease, Sjogren's syndrome (SjS), or independently...
  16. Sex, sex steroids and dry eye syndromes
    David A Sullivan; Fiscal Year: 2013
    ..essential role in maintaining ocular surface integrity, protecting against microbial challenge and preserving visual acuity. Tear film dysfunction, in turn, may severely impact the eye and lead to desiccation, ulceration and ..
  17. Visual Processing and Smooth Eye Movements
    Michael J Mustari; Fiscal Year: 2012
    ..Furthermore, to achieve maximum visual acuity and depth perception, we must be able to hold our eyes steady on a stationary or moving target...
  18. Regulation of Drosophila arrestins in light adaptation
    Bih Hwa Shieh; Fiscal Year: 2012
    ..a tangible drug target for future pharmacological intervention to prevent retinal degeneration and to enhance visual acuity. PUBLIC HEALTH RELEVANCE: We would like to investigate regulation of visual arrestins by reversible ..
  19. Achromatopsia - Disease Mechanisms and Cone-Directed Gene Therapy
    Andras Komaromy; Fiscal Year: 2013
    Cone photoreceptors are responsible for central visual acuity, color vision, and photopic vision and are therefore critical for visual performance in daily human life...
  20. rAAV5-hCNGB3 Gene Therapy for Achromatopsia: Safety and Efficacy in a Dog Model
    Guo jie Ye; Fiscal Year: 2013
    ..Patients with complete achromatopsia experience extreme light sensitivity and daytime blindness, and best visual acuity under non-bright light conditions is usually 20/200 or worse and generally stable over time...
  21. Training in Clinical Trials for Subjects with Low Vision
    Ava K Bittner; Fiscal Year: 2011
    ..Short term research aims are to determine whether within and between day fluctuations in visual acuity, contrast sensitivity and visual field among RP patients are associated with perceived stress, sleepiness or ..
  22. TRP channel expression and function in ON-bipolar cells
    Robert M Duvoisin; Fiscal Year: 2012
    ..and cone bipolar cells, further visual symptoms are apparent such as myopia, hyperopia, nystagmus, and reduced visual acuity. One such example are mutations in GRM6, the gene encoding mGluR6, which cause an autosomal recessive form of ..
  23. Smad3 inhibitors for ophthalmic applications
    Ching Yuan; Fiscal Year: 2010
    ..Since ocular tissues are vulnerable to fibrosis and neovascularization which can compromise the visual acuity, Smad3 inhibitors present new opportunities for treating above mentioned disorders in the eye...
  24. Aging and ARM: Dark Adaptation Impairment
    Cynthia Owsley; Fiscal Year: 2012
    ..The primary outcome measures used in clinical trials on advanced ARM visual acuity and grading of stereo fundus photos are not well suited as primary endpoints in clinical trials on early ARM ..
  25. Epidemiologic Research on Screening for Vestibular and Balance Disorders
    Helen S Cohen; Fiscal Year: 2012
    ..Tests of standing and walking balance and dynamic visual acuity will be included...
  26. Fast-Switching, High-Contrast, Electrochromic Sunwear for Persons with Age-Relate
    PRASANNA CHANDRASEKHAR; Fiscal Year: 2011
    ..3) Carry out detailed mobility, visual acuity, other tests with ARMD veterans recruited from Atlanta VA Center...
  27. MESA
    Karol Watson; Fiscal Year: 2012
    ..The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, ..
  28. MESA
    Karol Watson; Fiscal Year: 2010
    ..The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, ..
  29. MESA
    Karol Watson; Fiscal Year: 2011
    ..The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, ..
  30. Thalamic Visual Prosthesis
    John S Pezaris; Fiscal Year: 2013
    ..Specific Aim 1 is to measure the visual acuity of normal sighted human volunteers using a virtual reality (VR) simulation of sight as it might appear to a ..
  31. MESA
    Karol Watson; Fiscal Year: 2009
    ..The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, ..
  32. RETINAL GANGLION CELL AND AMACRINE CELL FUNCTION IN MOUSE MODELS OF ELEVATED INTR
    Benjamin J Frankfort; Fiscal Year: 2013
    ..RGCs simultaneously, and an optomotor system that allows for the reliable non-invasive assessment of both visual acuity and contrast sensitivity in living mice...
  33. Measures of Human Receptor and Post Receptor Activity
    Donald C Hood; Fiscal Year: 2013
    ..the hypothesis that rod fundus perimetry and fdOCT are more sensitive to progression in these diseases than visual acuity or measures of the area of atrophy on fundus photography...
  34. Therapeutic Effects of Cataract Removal in Alzheimer's Disease
    GROVER CLEVELAND GILMORE; Fiscal Year: 2013
    ..Primary Specific Aim. To determine the effects of cataract removal on visual acuity, spatial contrast sensitivity, vision dependent functions, visual information processing, and quality of life ..
  35. LIMITING FACTORS IN NORMAL AND AMBLYOPIC SPATIAL VISION
    DENNIS MICHAEL LEVI; Fiscal Year: 2012
    ..It affects visual acuity, contrast sensitivity and position acuity...
  36. Preschool Vision Screening by Parental Risk Factor Questionnaire
    Ruth E Manny; Fiscal Year: 2013
    ..The long-term sequelae of these conditions that degrade visual acuity (VA) and/or binocular vision can be minimized by early detection and treatment...
  37. MESA
    Richard A Kronmal; Fiscal Year: 2010
    ..The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, ..
  38. MESA
    Aaron R Folsom; Fiscal Year: 2012
    ..The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, ..
  39. MESA
    Richard A Kronmal; Fiscal Year: 2012
    ..The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, ..
  40. MESA
    Russell P Tracy; Fiscal Year: 2012
    ..The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, ..
  41. MESA
    Aaron R Folsom; Fiscal Year: 2013
    ..The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, ..
  42. MESA
    Richard A Kronmal; Fiscal Year: 2011
    ..The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, ..
  43. MESA
    Aaron R Folsom; Fiscal Year: 2011
    ..The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, ..
  44. MESA
    Aaron R Folsom; Fiscal Year: 2010
    ..The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, ..
  45. MESA
    Russell P Tracy; Fiscal Year: 2013
    ..The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, ..
  46. MESA
    Richard A Kronmal; Fiscal Year: 2013
    ..The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, ..
  47. MESA
    Russell P Tracy; Fiscal Year: 2011
    ..The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, ..
  48. MESA
    Russell P Tracy; Fiscal Year: 2010
    ..The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, ..
  49. Genetics of Diabetic Retinopathy in Hispanics
    Jerome I Rotter; Fiscal Year: 2011
    ..include collection of demographic and clinical data and an eye examination that will include assessment of visual acuity, measurement of intraocular pressure, and obtaining standard 7-field fundus photographs...
  50. MESA
    Richard A Kronmal; Fiscal Year: 2009
    ..The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, ..
  51. MESA
    Aaron R Folsom; Fiscal Year: 2009
    ..The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, ..
  52. MESA
    Russell P Tracy; Fiscal Year: 2009
    ..The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, ..
  53. Breastfeeding RCT: Adolescent Neurocognitive and Respiratory Function
    Emily Oken; Fiscal Year: 2013
    ..of prolonged, exclusive breastfeeding on child neurocognitive development (verbal and non-verbal cognition, visual acuity) and lung function...
  54. Follow-up Study: Comparison of AMD Treatments Trial (CATT)
    Maureen G Maguire; Fiscal Year: 2013
    ..a drug directed towards vascular endothelial growth factor (anti-VEGF), was highly effective in preserving visual acuity. While ranibizumab was in process for approval by the Food and Drug Administration, ophthalmologists adopted ..
  55. Design and development of a multifunctional self-service health screening kiosk
    STEPHEN KENDIG; Fiscal Year: 2013
    ..Our goal is to expand the offerings of a single function visual acuity screening, to a multifunctional health screening kiosk, focusing on risk factors that disproportionately ..
  56. Phase 2 Study of CNTF on Photoreceptor Structure in Retinitis Pigmentosa
    JACQUE LYNNE DUNCAN; Fiscal Year: 2012
    ..However, CNTF-treated eyes showed no improvement in visual acuity or visual field sensitivity, perhaps because standard measures of visual function are of lower resolution than ..
  57. Trigeminal-autonomic relations in ocular homeostasis
    David A Bereiter; Fiscal Year: 2013
    ..Disruption of trigeminal-PaNS relations may contribute to symptoms in diverse conditions as dry eye disease, glaucoma and ocular hypertension that can lead to loss of visual acuity and cause discomfort.
  58. MESA
    Gregory L Burke; Fiscal Year: 2011
    ..The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, ..
  59. MESA
    Kiang Liu; Fiscal Year: 2012
    ..The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, ..
  60. MESA
    Steven Shea; Fiscal Year: 2013
    ..The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, ..
  61. MESA
    Kiang Liu; Fiscal Year: 2011
    ..The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, ..
  62. MESA
    Wendy Post; Fiscal Year: 2012
    ..The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, ..
  63. MESA
    Wendy Post; Fiscal Year: 2010
    ..The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, ..
  64. MESA
    Gregory L Burke; Fiscal Year: 2010
    ..The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, ..
  65. MESA
    Steven Shea; Fiscal Year: 2012
    ..The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, ..
  66. MESA
    Gregory L Burke; Fiscal Year: 2012
    ..The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, ..
  67. Targeting Muller Cells to Treat Optic Nerve Injury
    Sherry Ball; Fiscal Year: 2009
    ..We will track retinal Muller cell and photoreceptor function using ERG and a behavioral test to measure visual acuity in mice treated with minocycline before and after experimentally induced optic nerve injury...
  68. Ocular Lymphangiogenesis
    DANIEL J CARR; Fiscal Year: 2010
    ..As a consequence, visual acuity can be compromised and in the case of infection, an adaptive immune response ensues through the "education" of ..
  69. SUBMACULAR SURGERY TRIALS--PHOTOGRAPH READING CENTER
    Susan Bressler; Fiscal Year: 2003
    ..The primary outcome for each trial will be change in visual acuity from baseline to the two-year examination, with better or same visual acuity as at baseline deemed a ..
  70. TEST OF TAURINE AS AN ESSENTIAL NUTRIENT
    John Sturman; Fiscal Year: 1993
    ..Their visual acuity was below normal during the first 3 postnatal months and they showed degenerative changes in retinal ..
  71. VA Low Vision Intervention Trial (LOVIT) II
    Joan Stelmack; Fiscal Year: 2009
    ..in improving visual reading ability for 330 veterans with macular diseases and best corrected distance visual acuity of 20/50-20/100 than the Basic Low Vision Service (optometrist alone providing low vision examination and ..
  72. DIETARY N-3 FATTY ACIDS: TRANSPORT AND UPTAKE INTO BRAIN
    Gregory Anderson; Fiscal Year: 1993
    ..These include reduced visual acuity, impaired learning, altered behavior, and effects on sleep...
  73. Signal Transduction Mechanisms in Ocular Albinism
    Vinit Mahajan; Fiscal Year: 2005
    ..decreased pigmentation of ocular tissues and suffer a characteristic series of traits that includes poor visual acuity, nystagmus, strabismus, reduced stereopsis, and photophobia...
  74. GROWTH OF OPTIC NERVE FIBERS
    Robert Williams; Fiscal Year: 1999
    ..Inborn errors of these connections are associated with poor foveal development, severe deficits in visual acuity, loss of binocular vision, strabismus, and eye movement disorders...
  75. MECHANISMS OF RADIATION SUPPRESSED CORNEAL ANGIOGENESIS
    MARK SCROGGS; Fiscal Year: 1991
    Neovascularization of the cornea is a significant cause of decreased visual acuity and blindness. It occurs in patients with trachoma and herpetic keratitis as well as in traumatic, inflammatory, toxic and nutritional disorders...
  76. Protection of Ocular Tissues During Inflammation
    MELVIN MEDOF; Fiscal Year: 2006
    ..pathogens that enter its open environment, the eye must protect itself from self cell damage that would impair visual acuity. In earlier work, we found that the decay accelerating factor (DAF or CD55), membrane cofactor protein (MCP or ..
  77. Modifiable Risk Factors for CME in Retinitis Pigmentosa
    Michael A Sandberg; Fiscal Year: 2010
    ..Cystoid macular edema (CME), a complication involving swelling of the central retina and reduction in visual acuity, occurs in at least 25% of patients with retinitis pigmentosa, often before their central vision has become ..
  78. Using light to increase visual and perceptual cues and decrease falls risk
    MARIANA FIGUEIRO; Fiscal Year: 2010
    ..This not only reduces visual acuity but also elevates contrast thresholds for all spatial frequencies (Nadler et al., 1990)...
  79. OPTIC NEURITIS TREATMENT TRIAL--COORDINATING CENTER
    Patricia Cleary; Fiscal Year: 1991
    ..Although visual acuity may return to normal, there is often still considerable abnormality in contrast sensitivity, color vision, ..