taste

Summary

Summary: The sensation or perception of certain qualities of substances put in the mouth, primarily sweet, sour, salt and bitter.

Top Publications

  1. pmc Ancient protostome origin of chemosensory ionotropic glutamate receptors and the evolution of insect taste and olfaction
    Vincent Croset
    Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
    PLoS Genet 6:e1001064. 2010
  2. ncbi Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways
    Yifeng Zhang
    Howard Hughes Medical Institute, Department of Biology, University of California, San Diego, La Jolla, CA 92093, USA
    Cell 112:293-301. 2003
  3. pmc Motor control in a Drosophila taste circuit
    Michael D Gordon
    Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, 291 Life Sciences Addition, University of California, Berkeley, Berkeley, CA 94720, USA
    Neuron 61:373-84. 2009
  4. pmc Odorant-binding proteins OBP57d and OBP57e affect taste perception and host-plant preference in Drosophila sechellia
    Takashi Matsuo
    Department of Biological Sciences, Tokyo Metropolitan University, Hachioji, Tokyo, Japan
    PLoS Biol 5:e118. 2007
  5. ncbi The molecular receptive ranges of human TAS2R bitter taste receptors
    Wolfgang Meyerhof
    Department of Molecular Genetics, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Chem Senses 35:157-70. 2010
  6. ncbi Neural responses during anticipation of a primary taste reward
    JOHN P O'DOHERTY
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, WC1 3BG, London, United Kingdom
    Neuron 33:815-26. 2002
  7. ncbi G protein-coupled receptors in human fat taste perception
    Maria Mercedes Galindo
    Department of Molecular Genetics, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Chem Senses 37:123-39. 2012
  8. ncbi Insect odor and taste receptors
    Elissa A Hallem
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Annu Rev Entomol 51:113-35. 2006
  9. pmc Motile cilia of human airway epithelia are chemosensory
    Alok S Shah
    Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Science 325:1131-4. 2009
  10. pmc The molecular and cellular basis of bitter taste in Drosophila
    Linnea A Weiss
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520 8103, USA
    Neuron 69:258-72. 2011

Detail Information

Publications350 found, 100 shown here

  1. pmc Ancient protostome origin of chemosensory ionotropic glutamate receptors and the evolution of insect taste and olfaction
    Vincent Croset
    Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
    PLoS Genet 6:e1001064. 2010
    ..divergent IRs," which are expressed in peripheral and internal gustatory neurons, implicating this family in taste and food assessment...
  2. ncbi Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways
    Yifeng Zhang
    Howard Hughes Medical Institute, Department of Biology, University of California, San Diego, La Jolla, CA 92093, USA
    Cell 112:293-301. 2003
    Mammals can taste a wide repertoire of chemosensory stimuli. Two unrelated families of receptors (T1Rs and T2Rs) mediate responses to sweet, amino acids, and bitter compounds...
  3. pmc Motor control in a Drosophila taste circuit
    Michael D Gordon
    Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, 291 Life Sciences Addition, University of California, Berkeley, Berkeley, CA 94720, USA
    Neuron 61:373-84. 2009
    ..Here, we use a neural silencing screen to identify neurons required for a simple Drosophila taste behavior and characterize a neural population that controls a specific subprogram of this behavior...
  4. pmc Odorant-binding proteins OBP57d and OBP57e affect taste perception and host-plant preference in Drosophila sechellia
    Takashi Matsuo
    Department of Biological Sciences, Tokyo Metropolitan University, Hachioji, Tokyo, Japan
    PLoS Biol 5:e118. 2007
    ..citrifolia. Our finding of the genes involved in host-plant determination may lead to further understanding of mechanisms underlying taste perception, evolution of plant-herbivore interactions, and speciation.
  5. ncbi The molecular receptive ranges of human TAS2R bitter taste receptors
    Wolfgang Meyerhof
    Department of Molecular Genetics, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Chem Senses 35:157-70. 2010
    Humans perceive thousands of compounds as bitter. In sharp contrast, only approximately 25 taste 2 receptors (TAS2R) bitter taste receptors have been identified, raising the question as to how the vast array of bitter compounds can be ..
  6. ncbi Neural responses during anticipation of a primary taste reward
    JOHN P O'DOHERTY
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, WC1 3BG, London, United Kingdom
    Neuron 33:815-26. 2002
    The aim of this study was to determine the brain regions involved in anticipation of a primary taste reward and to compare these regions to those responding to the receipt of a taste reward...
  7. ncbi G protein-coupled receptors in human fat taste perception
    Maria Mercedes Galindo
    Department of Molecular Genetics, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Chem Senses 37:123-39. 2012
    In contrast to carbohydrates and proteins, which are detected by specialized taste receptors in the forms of their respective building blocks, sugars, and L-amino acids, the third macronutrient, lipids, has until now not been associated ..
  8. ncbi Insect odor and taste receptors
    Elissa A Hallem
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Annu Rev Entomol 51:113-35. 2006
    Insect odor and taste receptors are highly sensitive detectors of food, mates, and oviposition sites...
  9. pmc Motile cilia of human airway epithelia are chemosensory
    Alok S Shah
    Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Science 325:1131-4. 2009
    ..We found that these cells express sensory bitter taste receptors, which localized on motile cilia...
  10. pmc The molecular and cellular basis of bitter taste in Drosophila
    Linnea A Weiss
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520 8103, USA
    Neuron 69:258-72. 2011
    The extent of diversity among bitter-sensing neurons is a fundamental issue in the field of taste. Data are limited and conflicting as to whether bitter neurons are broadly tuned and uniform, resulting in indiscriminate avoidance of ..
  11. ncbi Dissociation of neural representation of intensity and affective valuation in human gustation
    Dana M Small
    Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Feinberg Medical School, 320 East Superior Street, Chicago, IL 60611, USA
    Neuron 39:701-11. 2003
    We used a 2 x 2 factorial design to dissociate regions responding to taste intensity and taste affective valence. Two intensities each of a pleasant and unpleasant taste were presented to subjects during event-related fMRI scanning...
  12. pmc Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells
    S Vincent Wu
    Department of Medicine, School of Medicine, Center for Ulcer Research and Education Digestive Diseases Research Center, Veterans Administration Greater Los Angeles Healthcare System, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 99:2392-7. 2002
    ..Here we identified putative taste receptor gene transcripts in the gastrointestinal tract...
  13. pmc Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction
    Deepak A Deshpande
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Nat Med 16:1299-304. 2010
    Bitter taste receptors (TAS2Rs) on the tongue probably evolved to evoke signals for avoiding ingestion of plant toxins...
  14. pmc Taste-independent detection of the caloric content of sugar in Drosophila
    Monica Dus
    Molecular Neurobiology Program, Skirball Institute for Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 108:11644-9. 2011
    ..fly, Drosophila melanogaster, selects calorie-rich foods following prolonged food deprivation in the absence of taste-receptor signaling...
  15. pmc Major taste loss in carnivorous mammals
    Peihua Jiang
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 109:4956-61. 2012
    Mammalian sweet taste is primarily mediated by the type 1 taste receptor Tas1r2/Tas1r3, whereas Tas1r1/Tas1r3 act as the principal umami taste receptor...
  16. ncbi Taste, olfactory, and food texture processing in the brain, and the control of food intake
    Edmund T Rolls
    University of Oxford, Department of Experimental Psychology, South Parks Road, Oxford OX1 3UD, England, UK
    Physiol Behav 85:45-56. 2005
    Complementary neurophysiological recordings in macaques and functional neuroimaging in humans show that the primary taste cortex in the rostral insula and adjoining frontal operculum provides separate and combined representations of the ..
  17. ncbi Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide
    Un Kyung Kim
    National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, MD 20850, USA
    Science 299:1221-5. 2003
    The ability to taste the substance phenylthiocarbamide (PTC) has been widely used for genetic and anthropological studies, but genetic studies have produced conflicting results and demonstrated complex inheritance for this trait...
  18. pmc The cells and peripheral representation of sodium taste in mice
    Jayaram Chandrashekar
    Howard Hughes Medical Institute and Department of Neurobiology, University of California at San Diego, La Jolla, California 92093 0649, USA
    Nature 464:297-301. 2010
    Salt taste in mammals can trigger two divergent behavioural responses...
  19. pmc Nasal chemosensory cells use bitter taste signaling to detect irritants and bacterial signals
    Marco Tizzano
    Rocky Mountain Taste and Smell Center, Department of Cell and Developmental Biology, University of Colorado Denver, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 107:3210-5. 2010
    ..also houses a population of trigeminally innervated solitary chemosensory cells (SCCs) that express T2R bitter taste receptors along with their downstream signaling components...
  20. pmc Common sense about taste: from mammals to insects
    David A Yarmolinsky
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Cell 139:234-44. 2009
    The sense of taste is a specialized chemosensory system dedicated to the evaluation of food and drink...
  21. pmc Drosophila TRPA1 channel mediates chemical avoidance in gustatory receptor neurons
    Sang Hoon Kim
    Departmentsof Biological Chemistry and Neuroscience, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 107:8440-5. 2010
    Mammalian sweet, bitter, and umami taste is mediated by a single transduction pathway that includes a phospholipase C (PLC)beta and one cation channel, TRPM5...
  22. ncbi Gustatory and extragustatory functions of mammalian taste receptors
    Maik Behrens
    Department of Molecular Genetics, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Physiol Behav 105:4-13. 2011
    An ever increasing number of reports about taste receptors in non-gustatory tissues suggest that these molecules must have additional functions apart from taste...
  23. ncbi Taste perception and coding in Drosophila
    Natasha Thorne
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, 252 CARL Building Research Drive, Durham, NC 27710 USA
    Curr Biol 14:1065-79. 2004
    ..In Drosophila, a family of gustatory receptors (GRs) expressed in taste neurons is thought to mediate the recognition of sugars and bitter compounds, thereby controlling feeding behavior.
  24. pmc Remembering nutrient quality of sugar in Drosophila
    Christopher J Burke
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Curr Biol 21:746-50. 2011
    b>Taste is an early stage in food and drink selection for most animals [1, 2]. Detecting sweetness indicates the presence of sugar and possible caloric content...
  25. pmc Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion
    George A Kyriazis
    Metabolic Signaling and Disease, Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, FL 32827, USA
    Proc Natl Acad Sci U S A 109:E524-32. 2012
    ..We demonstrate that fructose activates sweet taste receptors (TRs) on beta cells and synergizes with glucose to amplify insulin release in human and mouse islets...
  26. ncbi Artificial sweeteners and salts producing a metallic taste sensation activate TRPV1 receptors
    Celine E Riera
    Nestle Research Center, P O Box 44, CH 1000 Lausanne 26, Switzerland
    Am J Physiol Regul Integr Comp Physiol 293:R626-34. 2007
    ..Recently, it has been shown that the activation of particular T2R bitter taste receptors is partially involved with the bitter aftertaste sensation of saccharin and acesulfame-K...
  27. ncbi The amiloride-sensitive epithelial Na+ channel PPK28 is essential for drosophila gustatory water reception
    Zijing Chen
    Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Neurosci 30:6247-52. 2010
    Water sensation is a specific taste modality in the fruit fly. Water-induced hypoosmolarity activates specific gustatory receptor neurons; however, the molecular identity of the putative osmolarity sensor in these neurons remains unknown...
  28. pmc The molecular basis for water taste in Drosophila
    Peter Cameron
    Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, CA, USA
    Nature 465:91-5. 2010
    ..the recognition of external water sources, but little is known about the underlying molecular mechanism for water taste detection...
  29. pmc A taste of the Drosophila gustatory receptors
    Craig Montell
    Department of Biological Chemistry, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Curr Opin Neurobiol 19:345-53. 2009
    ..Several GRs appear to be expressed in multiple cell types that are not associated with contact chemosensation raising the possibility that these proteins may have roles that extend beyond the detection of tastants and pheromones...
  30. ncbi Influence of genetic taste sensitivity to 6-n-propylthiouracil (PROP), dietary restraint and disinhibition on body mass index in middle-aged women
    Beverly J Tepper
    Department of Food Science, Cook College, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901 0231, USA
    Physiol Behav 75:305-12. 2002
    A previous study from our laboratory reported a small, inverse association between taste sensitivity to 6-n-propylthiouracil (PROP) and body mass index (BMI) among lean, young-adult males...
  31. pmc An fMRI study of obesity, food reward, and perceived caloric density. Does a low-fat label make food less appealing?
    Janet Ng
    Department of Psychology, University of Oregon, Eugene, OR 97403, USA
    Appetite 57:65-72. 2011
    ..Results suggest that hyper-responsivity of somatosensory, gustatory, and reward valuation regions may be related to overeating and that top-down processing influence reward encoding, which could further contribute to weight gain...
  32. ncbi A bad taste in the mouth: gustatory disgust influences moral judgment
    Kendall J Eskine
    Department of Psychology, The Graduate Center, City University of New York, Brooklyn, NY 11210, USA
    Psychol Sci 22:295-9. 2011
    ..and sometimes striking findings these studies have yielded, no research has explored morality in conjunction with taste, which can vary greatly and may differentially affect cognition...
  33. pmc Rapid evolution of smell and taste receptor genes during host specialization in Drosophila sechellia
    Carolyn S McBride
    Center for Population Biology, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 104:4996-5001. 2007
    ....
  34. pmc Sweet taste receptor expressed in pancreatic beta-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion
    Yuko Nakagawa
    Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan
    PLoS ONE 4:e5106. 2009
    Sweet taste receptor is expressed in the taste buds and enteroendocrine cells acting as a sugar sensor. We investigated the expression and function of the sweet taste receptor in MIN6 cells and mouse islets.
  35. ncbi Changes in brain activity related to eating chocolate: from pleasure to aversion
    D M Small
    Neuropsychology Cognitive Neuroscience Unit, and Northwestern Cognitive Brain Mapping Group, Northwestern University School of Medicine, Chicago, IL 60611, USA
    Brain 124:1720-33. 2001
    ..Therefore, these results support the hypothesis that there are two separate motivational systems: one orchestrating approach and another avoidance behaviours...
  36. ncbi Genetic taste sensitivity to 6-n-propylthiouracil influences food preference and reported intake in preschool children
    Kathleen L Keller
    Department of Food Science, Cook College, Rutgers University, New Brunswick, NJ, USA
    Appetite 38:3-12. 2002
    Adult tasters of 6-n-propylthiouracil (PROP) are more sensitive to bitter taste and fattiness in foods, and often show lower acceptance of foods that are high in these taste qualities...
  37. pmc Ghrelin increases intake of rewarding food in rodents
    Emil Egecioglu
    Department of Physiology Endocrinology, The Sahlgrenska Academy at the University of Gothenburg, SE 405 30 Gothenburg, Sweden
    Addict Biol 15:304-11. 2010
    ..Our data support the hypothesis that central ghrelin signaling at the level of the VTA is important for the incentive value of rewarding food...
  38. pmc A Drosophila gustatory receptor essential for aversive taste and inhibiting male-to-male courtship
    Seok Jun Moon
    Departments of Biological Chemistry and Neuroscience, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Curr Biol 19:1623-7. 2009
    ..However, GR32a is dispensable for normal taste. Thus, distinct GRs may function in sensing avoidance pheromones and antifeedants...
  39. ncbi Bad popcorn in big buckets: portion size can influence intake as much as taste
    Brian Wansink
    Department of Applied Economics and Management, Cornell University, Ithica, New York, USA
    J Nutr Educ Behav 37:242-5. 2005
    ..It is often believed that people overeat the foods they like. We investigated whether environmental cues such as packaging and container size are so powerful that they can increase our intake of foods that are less palatable...
  40. ncbi In bad taste: evidence for the oral origins of moral disgust
    H A Chapman
    Department of Psychology, University of Toronto, Toronto, Ontario M5S 3G3, Canada
    Science 323:1222-6. 2009
    In common parlance, moral transgressions "leave a bad taste in the mouth...
  41. ncbi The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides
    Bernd Bufe
    Department of Molecular Genetics, German Institute of Human Nutrition, Arthur Scheunert Allee 114 116, 14558 Potsdam Rehbrücke, Germany
    Nat Genet 32:397-401. 2002
    Bitter taste generally causes aversion, which protects humans from ingesting toxic substances. But bitter flavors also contribute to the palatability of food and beverages, thereby influencing nutritional habits in humans...
  42. pmc Nonnutritive sweetener consumption in humans: effects on appetite and food intake and their putative mechanisms
    Richard D Mattes
    Department of Foods and Nutrition, Purdue University, West Lafayette, IN, USA
    Am J Clin Nutr 89:1-14. 2009
    ..Most of the purported mechanisms by which this occurs are not supported by the available evidence, although some warrant further consideration. Resolution of this important issue will require long-term randomized controlled trials...
  43. pmc Two Gr genes underlie sugar reception in Drosophila
    Anupama Dahanukar
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520 8103, USA
    Neuron 56:503-16. 2007
    ..Using in situ hybridization and reporter gene expression, we identify members of the Gr5a-related taste receptor subfamily that are coexpressed in sugar neurons...
  44. ncbi The detection of carbonation by the Drosophila gustatory system
    Walter Fischler
    Department of Molecular and Cell Biology, 291 Life Sciences Addition, University of California Berkeley, Berkeley, California 94720, USA
    Nature 448:1054-7. 2007
    There are five known taste modalities in humans: sweet, bitter, sour, salty and umami (the taste of monosodium glutamate)...
  45. pmc The cell biology of taste
    Nirupa Chaudhari
    Department of Physiology and Biophysics, and Program in Neurosciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Cell Biol 190:285-96. 2010
    b>Taste buds are aggregates of 50-100 polarized neuroepithelial cells that detect nutrients and other compounds. Combined analyses of gene expression and cellular function reveal an elegant cellular organization within the taste bud...
  46. ncbi Sucrose activates human taste pathways differently from artificial sweetener
    Guido K W Frank
    University of Colorado at Denver and Health Sciences Center, Department of Psychiatry, The Children s Hospital, Aurora, CO 80045, USA
    Neuroimage 39:1559-69. 2008
    Animal models suggest that sucrose activates taste afferents differently than non-caloric sweeteners. Little information exists how artificial sweeteners engage central taste pathways in the human brain...
  47. ncbi A Gr receptor is required for response to the sugar trehalose in taste neurons of Drosophila
    A Dahanukar
    Department of Molecular, Cellular, and Developmental Biology, Yale University, PO Box 208103, New Haven, Connecticut 06520 8103, USA
    Nat Neurosci 4:1182-6. 2001
    ..genome database a large family of G protein-coupled receptor genes, the Gr genes, and predicted that they encode taste receptors on the basis of their structure and specificity of expression...
  48. ncbi Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells
    Carole Bezençon
    Nestle Research Center, Vers chez les Blanc, Lausanne, Switzerland
    Chem Senses 32:41-9. 2007
    The taste system, made up of taste receptor cells clustered in taste buds at the surface of the tongue and the soft palate, plays a key role in the decision to ingest or reject food and thereby is essential in protecting organisms ..
  49. ncbi Taste preference for fatty acids is mediated by GPR40 and GPR120
    Cristina Cartoni
    Nestle Research Center, Lausanne 1000, Switzerland
    J Neurosci 30:8376-82. 2010
    ..of fat has traditionally been considered to rely mainly on texture and olfaction, but recent findings suggest that taste may also play a role in the detection of long chain fatty acids...
  50. ncbi Pictures of appetizing foods activate gustatory cortices for taste and reward
    W Kyle Simmons
    Department of Psychology, Emory University, Atlanta, GA 30322, USA
    Cereb Cortex 15:1602-8. 2005
    ..pattern completion, food pictures activate gustatory regions of the circuit to produce conceptual inferences about taste. Consistent with theories that ground knowledge in the modalities, these inferences arise as reenactments of ..
  51. ncbi Polymorphisms in TAS2R38 and the taste bud trophic factor, gustin gene co-operate in modulating PROP taste phenotype
    Carla Calo
    Department of Experimental Biology, Section of Anthropology, Monserrato, CA, I 09042, Italy
    Physiol Behav 104:1065-71. 2011
    The PROP taste phenotype varies greatly among individuals, influencing eating behavior and therefore may play a role in body composition...
  52. pmc Effects of cigarette smoking and family history of alcoholism on sweet taste perception and food cravings in women
    Marta Yanina Pepino
    Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA
    Alcohol Clin Exp Res 31:1891-9. 2007
    ....
  53. ncbi Taste preferences and food intake
    A Drewnowski
    Human Nutrition Program, School of Public Health, The University of Michigan, Ann Arbor 48109, USA
    Annu Rev Nutr 17:237-53. 1997
    Sensory responses to the taste, smell, and texture of foods help determine food preferences and eating habits. However, sensory responses alone do not predict food consumption...
  54. pmc Expression, regulation and putative nutrient-sensing function of taste GPCRs in the heart
    Simon R Foster
    University of Queensland, School of Biomedical Sciences, Brisbane, Australia
    PLoS ONE 8:e64579. 2013
    ..Moreover, there is a growing appreciation that members of the large, distinct taste and odorant GPCR families have specific functions in tissues beyond the oronasal cavity, including in the brain, ..
  55. ncbi Cyanotoxin mixtures and taste-and-odor compounds in cyanobacterial blooms from the Midwestern United States
    Jennifer L Graham
    United States Geological Survey, Kansas Water Science Center, 4821 Quail Crest Place, Lawrence, Kansas 66049, USA
    Environ Sci Technol 44:7361-8. 2010
    The mixtures of toxins and taste-and-odor compounds present during cyanobacterial blooms are not well characterized and of particular concern when evaluating potential human health risks...
  56. pmc Sweetener preference of C57BL/6ByJ and 129P3/J mice
    A A Bachmanov
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Chem Senses 26:905-13. 2001
    Previous studies have shown large differences in taste responses to several sweeteners between mice of the C57BL/6ByJ (B6) and 129P3/J (129) inbred strains...
  57. pmc High salt recruits aversive taste pathways
    Yuki Oka
    Howard Hughes Medical Institute and Department of Biochemistry and Molecular Biophysics, Columbia College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Nature 494:472-5. 2013
    In the tongue, distinct classes of taste receptor cells detect the five basic tastes; sweet, sour, bitter, sodium salt and umami...
  58. ncbi Integration of taste and calorie sensing in Drosophila
    Jeffrey W Stafford
    Department of Zoology, Cell and Developmental Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Neurosci 32:14767-74. 2012
    ..For example, the taste of sugar generally signals a potent dietary source of carbohydrates...
  59. pmc Functional characterization of bitter-taste receptors expressed in mammalian testis
    Jiang Xu
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Mol Hum Reprod 19:17-28. 2013
    ..Here, we show that many bitter-taste receptors (T2rs), which are believed to function as gatekeepers in the oral cavity to detect and innately prevent ..
  60. pmc Optogenetic induction of aversive taste memory
    Alex C Keene
    Department of Biology, University of Nevada, Reno, NV, United States
    Neuroscience 222:173-80. 2012
    The Drosophila melanogaster gustatory system consists of several neuronal pathways representing diverse taste modalities...
  61. ncbi Lingual tactile acuity, taste perception, and the density and diameter of fungiform papillae in female subjects
    Greg K Essick
    Department of Prosthodontics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7450, USA
    Physiol Behav 80:289-302. 2003
    A growing body of evidence suggests that individuals who differ in taste perception differ in lingual tactile perception...
  62. ncbi Differences in health and taste attitudes and reported behaviour among Finnish, Dutch and British consumers: a cross-national validation of the Health and Taste Attitude Scales (HTAS)
    K Roininen
    Department of Food Technology, University of Helsinki, Finland
    Appetite 37:33-45. 2001
    The Health and Taste Attitude Scales (HTAS) developed by Roininen, Lähteenmäki and Tuorila in 1999 measure the importance of health and taste aspects of foods in the food choice process...
  63. ncbi Food selection and taste changes in humans after Roux-en-Y gastric bypass surgery: a direct-measures approach
    Clare M Mathes
    Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA
    Physiol Behav 107:476-83. 2012
    ..to changes in patient food selection, and that this change may stem from effects of the operation on the sense of taste. In this review, we evaluate the literature examining postoperative changes in food intake and food choice...
  64. pmc Sensitivity of genome-wide-association signals to phenotyping strategy: the PROP-TAS2R38 taste association as a benchmark
    Ulrich K Genick
    Department of Food Consumer Interaction, Nestle Research Center, Lausanne, Switzerland
    PLoS ONE 6:e27745. 2011
    Natural genetic variation can have a pronounced influence on human taste perception, which in turn may influence food preference and dietary choice. Genome-wide association studies represent a powerful tool to understand this influence...
  65. ncbi The pharmacology and signaling of bitter, sweet, and umami taste sensing
    R Kyle Palmer
    Redpoint Bio Corporation, 2005 Eastpark Blvd, Cranbury, NJ 08512, USA
    Mol Interv 7:87-98. 2007
    Over the last decade, many of the molecular components that mediate the transduction of taste signaling have been elucidated...
  66. pmc Accumulating evidence supports a taste component for free fatty acids in humans
    Richard D Mattes
    Department of Foods and Nutrition, Purdue University, 700 W State Street, West Lafayette, IN 47907 2059, USA
    Physiol Behav 104:624-31. 2011
    The requisite criteria for what constitutes a taste primary have not been established...
  67. pmc Knocking out P2X receptors reduces transmitter secretion in taste buds
    Yijen A Huang
    Department of Physiology and Biophysics, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Neurosci 31:13654-61. 2011
    In response to gustatory stimulation, taste bud cells release a transmitter, ATP, that activates P2X2 and P2X3 receptors on gustatory afferent fibers...
  68. pmc Double P2X2/P2X3 purinergic receptor knockout mice do not taste NaCl or the artificial sweetener SC45647
    Meghan C Eddy
    Department of Biology, University of Vermont, Burlington, VT 05405, USA
    Chem Senses 34:789-97. 2009
    The P2X ionotropic purinergic receptors, P2X2 and P2X3, are essential for transmission of taste information from taste buds to the gustatory nerves...
  69. ncbi Magic at the marketplace: Choice blindness for the taste of jam and the smell of tea
    Lars Hall
    Lund University Cognitive Science, Lund University, Sweden
    Cognition 117:54-61. 2010
    ..like Cinnamon-Apple and bitter Grapefruit, or the smell of Mango and Pernod was no more than half of all trials detected, thus demonstrating considerable levels of choice blindness for the taste and smell of two different consumer goods.
  70. pmc Involvement of the calcium-sensing receptor in human taste perception
    Takeaki Ohsu
    Pharmaceutical Research Laboratories, Ajinomoto Company, Incorporated, Kawasaki 210 8681, Japan
    J Biol Chem 285:1016-22. 2010
    ..calcium-sensing receptor (CaSR) agonists enhance sweet, salty, and umami tastes, although they have no taste themselves. These characteristics are known as "kokumi taste" and often appear in traditional Japanese cuisine...
  71. ncbi Contribution of Drosophila DEG/ENaC genes to salt taste
    Lei Liu
    Howard Hughes Medical Institute and Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City 52242, USA
    Neuron 39:133-46. 2003
    ..We found the Drosophila DEG/ENaC genes Pickpocket11 (ppk11) and Pickpocket19 (ppk19) expressed in the larval taste-sensing terminal organ and in adults on the taste bristles of the labelum, the legs, and the wing margins...
  72. ncbi Imaging taste responses in the fly brain reveals a functional map of taste category and behavior
    Sunanda Marella
    Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, 291 Life Sciences Addition, University of California, Berkeley, Berkeley, California 94720, USA
    Neuron 49:285-95. 2006
    The sense of taste allows animals to distinguish nutritious and toxic substances and elicits food acceptance or avoidance behaviors...
  73. ncbi The receptors and cells for mammalian taste
    Jayaram Chandrashekar
    Howard Hughes Medical Institute and Departments of Neurobiology and Neurosciences, University of California at San Diego, La Jolla, California 92093 0649, USA
    Nature 444:288-94. 2006
    The emerging picture of taste coding at the periphery is one of elegant simplicity...
  74. ncbi Development of food preferences
    L L Birch
    Department of Human Development and Family Studies, Pennsylvania State University, University Park 16802, USA
    Annu Rev Nutr 19:41-62. 1999
    ....
  75. ncbi Opioid modulation of taste hedonics within the ventral striatum
    A E Kelley
    Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Blvd, Madison, WI 53719, USA
    Physiol Behav 76:365-77. 2002
    ..However, in modern times, with unlimited supplies of high-calorie food, it has contributed to the present epidemic of obesity...
  76. ncbi Intra-amygdala ZIP injections impair the memory of learned active avoidance responses and attenuate conditioned taste-aversion acquisition in rats
    Fernando Gámiz
    Department of Experimental Psychology and Physiology of Behaviour, Institute of Neurosciences, Centre for Biomedical Research CIBM, University of Granada, Campus Cartuja, 18071 Granada, Spain
    Learn Mem 18:529-33. 2011
    ..basolateral amygdala (BLA) upon the retention of a nonspatial learned active avoidance response and conditioned taste-aversion (CTA) acquisition in rats...
  77. ncbi Comparative expression of hedonic impact: affective reactions to taste by human infants and other primates
    J E Steiner
    Department of Oral Biology, The Hebrew University, Jerusalem, Israel
    Neurosci Biobehav Rev 25:53-74. 2001
    ..The taste of sucrose elicited homologous positive hedonic patterns of facial affective reactions from humans and other ..
  78. ncbi Taste-olfactory convergence, and the representation of the pleasantness of flavour, in the human brain
    Ivan E T de Araujo
    University of Oxford, Department of Experimental Psychology, South Parks Road, Oxford OX1 3UD, UK
    Eur J Neurosci 18:2059-68. 2003
    The functional architecture of the central taste and olfactory systems in primates provides evidence that the convergence of taste and smell information onto single neurons is realized in the caudal orbitofrontal cortex (and immediately ..
  79. ncbi Adaptive diversification of bitter taste receptor genes in Mammalian evolution
    Peng Shi
    Laboratory of Molecular Evolution and Genome Diversity, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
    Mol Biol Evol 20:805-14. 2003
    The diversity and evolution of bitter taste perception in mammals is not well understood. Recent discoveries of bitter taste receptor (T2R) genes provide an opportunity for a genetic approach to this question...
  80. ncbi Representation of pleasant and aversive taste in the human brain
    E T Rolls
    Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom
    J Neurophysiol 85:1315-21. 2001
    In this study, the representation of taste in the orbitofrontal cortex was investigated to determine whether or not a pleasant and an aversive taste have distinct or overlapping representations in this region...
  81. pmc Presynaptic (Type III) cells in mouse taste buds sense sour (acid) taste
    Yijen A Huang
    Department of Physiology and Biophysics, University of Miami School of Medicine, 1600 NW 10th Ave, Miami, FL 33136, USA
    J Physiol 586:2903-12. 2008
    b>Taste buds contain two types of cells that directly participate in taste transduction - receptor (Type II) cells and presynaptic (Type III) cells...
  82. ncbi Zinc supplementation improved cognitive performance and taste acuity in Indian adolescent girls
    Rama P Tupe
    Agharkar Research Institute, GG Agarkar Road, Pune 411 004, India
    J Am Coll Nutr 28:388-96. 2009
    To test the efficacy of zinc supplementation through diet or ayurvedic zinc tablet on cognitive function and taste acuity in adolescent girls.
  83. ncbi Amino acids, taste circuits, and feeding behavior in Drosophila: towards understanding the psychology of feeding in flies and man
    Christoph Melcher
    Institute for Genetics, Forschungszentrum Karlsruhe, Karlsruhe, Germany
    J Endocrinol 192:467-72. 2007
    ..We focus on the pivotal role of the central nervous system in integrating external and internal feeding-relevant information, thus enabling the organism to make one of the most basic decisions - to eat or not to eat...
  84. ncbi A role for prefrontal cortex in the extinction of a conditioned taste aversion
    G Andrew Mickley
    Department of Psychology and the Neuroscience Program, Baldwin Wallace College, 275 Eastland Road, Berea, OH 44017 2088, USA
    Brain Res 1051:176-82. 2005
    ..methods to determine if the medial prefrontal cortex (mPFC) is involved in the extinction of a conditioned taste aversion (CTA)...
  85. ncbi Conditioned taste aversion as a learning and memory paradigm
    H Welzl
    Division of Neuroanatomy and Behavior, Institute of Anatomy, University of Zurich, 8057 Zurich, Switzerland
    Behav Brain Res 125:205-13. 2001
    Conditioned taste aversion (CTA) is a well established learning and memory paradigm in rats and mice that is considered to be a special form of classical conditioning...
  86. ncbi Genetic variation in taste perception: does it have a role in healthy eating?
    E Feeney
    UCD Institute of Food and Health, School of Agriculture, Food Science and Veterinary Medicine, UCD, Belfield, Republic of Ireland
    Proc Nutr Soc 70:135-43. 2011
    b>Taste is often cited as the factor of greatest significance in food choice, and has been described as the body's 'nutritional gatekeeper'...
  87. pmc Residual chemosensory capabilities in double P2X2/P2X3 purinergic receptor null mice: intraoral or postingestive detection?
    Robert M Hallock
    Department of Cell and Developmental Biology, University of Colorado Denver, MS 8108, PO Box 6511, Aurora, CO 80045 6511, USA
    Chem Senses 34:799-808. 2009
    ..In contrast, in brief access tests, P2X2/P2X3(Dbl-/-) mice avoided citric acid and hydrochloric acid at the same concentrations as their wild-type counterparts, indicating that these weak acids activate oropharyngeal chemoreceptors...
  88. pmc Evolution of the sweet taste receptor gene Tas1r2 in bats
    Huabin Zhao
    School of Life Sciences, East China Normal University, Shanghai 200062, China
    Mol Biol Evol 27:2642-50. 2010
    b>Taste perception is an important component of an animal's fitness...
  89. ncbi The calcium-sensing receptor in taste tissue
    Ana San Gabriel
    Institute of Life Sciences, Ajinomoto Co Inc, Suzuki cho 1 1, Kawasaki ku, Kawasaki 210 8681, Japan
    Biochem Biophys Res Commun 378:414-8. 2009
    Calcium is an essential nutrient that induces a distinctive taste quality, but the sensing mechanism of calcium in the tongue is poorly understood. A recent study linked calcium to T1R3 receptor...
  90. ncbi Electrophysiology of appetitive taste and appetitive taste conditioning in humans
    Ingmar H A Franken
    Institute of Psychology, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Biol Psychol 86:273-8. 2011
    ..novel aspects of appetitive processing and conditioning: the electrophysiological response to (a) the appetitive taste of a sweet fluid and (b) appetitively/taste conditioned visual stimuli...
  91. ncbi The Drosophila Pox neuro gene: control of male courtship behavior and fertility as revealed by a complete dissection of all enhancers
    Werner Boll
    Institute for Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Development 129:5667-81. 2002
    ....
  92. ncbi Taste receptors in the gastrointestinal tract. I. Bitter taste receptors and alpha-gustducin in the mammalian gut
    Enrique Rozengurt
    Division of Digestive Diseases and CURE Digestive Diseases Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 1786, USA
    Am J Physiol Gastrointest Liver Physiol 291:G171-7. 2006
    ..that there are important similarities between the chemosensory machinery elucidated in specialized neuroepithelial taste receptor cells of the lingual epithelium and the molecular transducers localized recently in enteroendocrine open ..
  93. ncbi A TAS1R receptor-based explanation of sweet 'water-taste'
    Veronica Galindo-Cuspinera
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104, USA
    Nature 441:354-7. 2006
    ..One theory posits that 'water-tastes' are adaptation phenomena, in which adaptation to one taste solution causes the water presented subsequently to act as a taste stimulus...
  94. ncbi Short-term vegetable intake by young children classified by 6-n-propylthoiuracil bitter-taste phenotype
    Kendra I Bell
    Department of Food Science, Cook College, Rutgers University, New Brunswick, NJ 08901 8520, USA
    Am J Clin Nutr 84:245-51. 2006
    ..Genetic variation in sensitivity to the bitterness of 6-n-propylthiouracil (PROP) is thought to play a role in the acceptance and rejection of bitter-tasting vegetables by young children...
  95. ncbi Gustatory perception and behavior in Drosophila melanogaster
    Hubert Amrein
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Curr Biol 15:R673-84. 2005
    The sense of taste is essential for the survival of virtually all animals. Considered a 'primitive sense' and present in the form of chemotaxis in many bacteria, taste is also a sense of sophistication in humans...
  96. ncbi Quantitative analysis of taste bud cell numbers in fungiform and soft palate taste buds of mice
    Yoshitaka Ohtubo
    Kyushu Institute of Technology, Hibikino 2 4, Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Kitakyushu 808 0196, Japan
    Brain Res 1367:13-21. 2011
    Mammalian taste bud cells (TBCs) consist of several cell types equipped with different taste receptor molecules, and hence the ratio of cell types in a taste bud constitutes the taste responses of the taste bud...
  97. ncbi An amino-acid taste receptor
    Greg Nelson
    Howard Hughes Medical Institute and Departments of Biology and Neurosciences, University of California at San Diego, La Jolla, California, 92093 0649, USA
    Nature 416:199-202. 2002
    The sense of taste provides animals with valuable information about the nature and quality of food...
  98. pmc Sour taste responses in mice lacking PKD channels
    Nao Horio
    Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University, Fukuoka, Japan
    PLoS ONE 6:e20007. 2011
    ..kidney disease-like ion channel PKD2L1 and its associated partner PKD1L3 are potential candidates for sour taste receptors...
  99. pmc Limited taste discrimination in Drosophila
    Pavel Masek
    Department of Molecular and Cell Biology and the Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 107:14833-8. 2010
    In the gustatory systems of mammals and flies, different populations of sensory cells recognize different taste modalities, such that there are cells that respond selectively to sugars and others to bitter compounds...
  100. ncbi Genomic, genetic and functional dissection of bitter taste responses to artificial sweeteners
    Natacha Roudnitzky
    Department of Molecular Genetics, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Hum Mol Genet 20:3437-49. 2011
    Bitter taste perception is initiated by TAS2R receptors, which respond to agonists by triggering depolarization of taste bud cells. Mutations in TAS2Rs are known to affect taste phenotypes by altering receptor function...
  101. ncbi Altered insula response to taste stimuli in individuals recovered from restricting-type anorexia nervosa
    Angela Wagner
    Department of Psychiatry, School of Medicine, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 33:513-23. 2008
    ..We examined whether there is a primary disturbance of taste processing and experience of pleasure using a sucrose/water task in conjunction with functional magnetic resonance ..

Research Grants74

  1. PKC delta and cell renewal in irradiated taste epithelium
    MARY ELAINE REYLAND; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Taste dysfunction, either loss or alteration in sensation, is a common occurrence during radiotherapy for head and neck cancer...
  2. CHEMOSENSORY PERCEPTION AND PSYCHOPHYSICS IN THE AGED
    CLAIRE L MURPHY; Fiscal Year: 2013
    ..The costs of these services are considerable. Impairment of taste and olfactory function can negatively impact dietary selection, nutritional status, morbidity and mortality in ..
  3. High affinity capturing agents for strychnine
    Kit S Lam; Fiscal Year: 2011
    ..It is also one of the most bitter known substances and the taste can be detected as low as 1ppm...
  4. Development of Montelukast Delivery System for Childhood Asthma
    Je Phil Ryoo; Fiscal Year: 2013
    ..was formulated by incorporating the drug together with Bio-FX oral cavity absorption enhancers, polymer carriers, taste-masking agents and other excipients, and display many advantages including fast onset and improved bioavailability,..
  5. Novel Phosphate Binder: Effects on Hyperphosphatemia, Vascular Calcification & Bo
    DEANNA J contact NELSON; Fiscal Year: 2010
    ..with very poor patient compliance due to a host of problems, including side effects that run the gamut of poor taste, halitosis, gastric bloating, constipation, the number of pills, and cost...
  6. Multiple Mechanisms of Nasal Chemoreception
    Diego Restrepo; Fiscal Year: 2012
    ..This basic science study is performed within the context of the Rocky Mountain Taste and Smell Center (RMTSC), an entity dedicated to basic and clinically-relevant research on olfaction and taste...
  7. Biosynthesis of Microbial Isoprenoids
    David E Cane; Fiscal Year: 2013
    ..odor of moist soil, are also the cause of periodic, widely occurring, and costly episodes of unpleasant taste and odor in public drinking water supplies and in aquaculture...
  8. Epigenetics and choline: mediation of fetal alcohol effects in a rat model
    Carol L Cheatham; Fiscal Year: 2013
    ..The goal of Experiment 1 is to determine if the taste of choline will deter the rat from consuming as much ethanol as the ethanol-only group...
  9. Monoamine Contributions to Neurocircuitry in Eating Disorders
    Walter H Kaye; Fiscal Year: 2013
    ..neurocircuits and to investigate how those circuits modulate appetitive neural circuitry when responding to the taste of sugar, which might explain why AN are able to starve themselves and become emaciated, while BN periodically ..
  10. MAP KINASE IN ISLET FUNCTION
    Melanie H Cobb; Fiscal Year: 2013
    ..In aim 1 we will determine the functions of the taste receptor complex (T1R1/T1R3) in pancreatic cells...
  11. Role of TRPM1 (Melastatin1) in the Biology of Human Melanocytes
    Vijayasaradhi Setaluri; Fiscal Year: 2012
    ..These processes include photoperception, thermosensation, taste perception, mechanosensation, pain perception, Mg2+ homeostasis in kidney, smooth muscle tone and blood pressure ..
  12. Mechanisms of comorbidity between epilepsy and depression
    Andrey M Mazarati; Fiscal Year: 2013
    ..of depression - despair, as examined in the forced swim test, and anhedonia, analyzed using saccharin consumption taste preference test...
  13. Oral Immunobiology of MCMV-infected Mouse Salivary Glands
    Steven D London; Fiscal Year: 2010
    ..Saliva functions to moisten the oral tissues as an aid for speech, as a solvent important for taste, and as a masticatory wetting agent/lubricant important in swallowing food...
  14. Biomarkers to Guide Treatment and Improve Survival in Oral/Oropharyngeal Cancer
    Thomas E Carey; Fiscal Year: 2012
    ..based on radical surgery and radiation are associated with profound functional morbidity affecting communication, taste, smell, swallowing, cosmesis, sense of self, and overall quality of life...
  15. Physiology and regulation of T2R bitter taste receptors in enteroendocrine cells
    Timothy F Osborne; Fiscal Year: 2013
    ..These taste 2 receptors (T2Rs) are encoded by a family of single-exon g- protein coupled receptor (GPCR) genes and are ..
  16. Mechanisms of glucosensation mediating food choice behavior in Drosophila
    Monica Dus; Fiscal Year: 2013
    ..and found that flies are equipped with a mechanism to detect the nutritional value of food independently of taste. Specifically, food-deprived flies prefer calorie-rich sugars to zero-calorie sweeteners...
  17. East African Cichlids: A Natural Model for Dental Regeneration
    RYAN FREDRIC BLOOMQUIST; Fiscal Year: 2013
    ..In supporting research, I noted that cichlid teeth and taste buds share a common epithelial ribbon, as well as gene co-expression, during development and regeneration...
  18. Mechanisms of Adult Taste Bud Regeneration
    Linda A Barlow; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Taste is a fundamental sense, which increasingly has been implicated in dietary choices that contribute to obesity and thus to human health...
  19. Functional Characterization of CXCL14, CXCL17, and CCL28; three mucosal chemokine
    Albert Zlotnik; Fiscal Year: 2010
    ..Finally, we have observed that one of these chemokines, CXCL14, is specifically expressed in taste buds but not in lingual epithelium...
  20. Genone-wide Discovery of Molecular Alterations in Head and Neck Cancer
    Victor E Velculescu; Fiscal Year: 2010
    ..Oral cancer affects physical appearance and vital functions, including taste, swallowing, and speech/phonation...
  21. Effects on Caffeine on Adolescent Behavior and Physiology
    Jennifer L Temple; Fiscal Year: 2010
    ..Specific Aim 2 will measure how chronic and acute caffeine modulates taste preferences for novel drinks...
  22. Screening New Therapeutics for the Treatment of Post Traumatic Stress Disorder
    NEAL GORDON SIMON; Fiscal Year: 2011
    ..conditioning, we have shown using fMRI that rats exposed to a natural predator, a ferret, while experiencing the taste of sucrose exhibit a hyperarousal pattern of brain activity in the limbic cortex and hippocampus in response to ..
  23. Sweet taste receptors and glucose metabolism in healthy and T2DM humans
    Karen L Teff; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The recent identification of taste-receptor signaling elements in the gastrointestinal tract has fueled tremendous excitement with regards to the potential role of the taste system in nutrient ..
  24. The molecular basis for a broad range of phenotypes related to hTAS2R38
    Sarah V Lipchock; Fiscal Year: 2012
    The proposed research aims to examine the molecular basis for differences in individual taste preferences and sensitivities...
  25. Modulation of Taste-Related Behavior by Molecular Mediators of Appetite &Satiety
    Cedrick D Dotson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Two paradigm-shifting discoveries in taste research in recent years have realigned our thinking as to how taste perception is linked to mechanisms of appetite and satiety...
  26. The role of taste in amino acid appetite
    Ivan E de Araujo; Fiscal Year: 2013
    ..carbohydrate intake in both wild-type and genetically engineered taste-impaired mice...
  27. Novel transgenic reporter/deleter allele for Type I taste cells
    Sue Kinnamon; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Taste buds are the transducing elements of gustatory sensation...
  28. Taste and feeding circuits in Drosophila
    MICHAEL DOUGLAS GORDON; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The neural circuits underlying taste perception and feeding are critical for an animal's health and survival...
  29. Trigeminal Mechanisms of Oral Irritation
    Earl Carstens; Fiscal Year: 2009
    ..g., cross-desensitization), and if humans can qualitatively discriminate between irritants independent of taste or smell cues. Specific Aim 2...
  30. Effects of expectation on gustatory cortical activity
    Alfredo Fontanini; Fiscal Year: 2013
    ..is interpreted differently depending on what the animal expects: humans - and their brains - led to expect a mild taste, for instance, can be "fooled" into thinking that a bitter taste is milder than it actually is...
  31. Motivational Changes for Nutritionally Relevant Tastes after Gastric Bypass
    Alan C Spector; Fiscal Year: 2013
    ..Moreover, there are many anecdotal reports from patients that they experience changes in taste sensibility...
  32. Fetal Nicotine Exposure and Chemosensory Plasticity
    Steven L Youngentob; Fiscal Year: 2010
    ..contribute to the risk of tobacco-related product use and abuse in adolescence because these products "smell and taste better"...
  33. Taste and Cyclophosphamide in Mice
    Eugene R Delay; Fiscal Year: 2013
    ..to treat cancer, will serve as a prototypical agent to study novel questions about how chemotherapy drugs disrupt taste, how cell populations within taste buds are renewed, and how we might protect these cells from the effects of ..
  34. Brain Reward Circuits and Computational Modeling in Adolescent Anorexia Nervosa
    GUIDO KW FRANK; Fiscal Year: 2013
    ..Results will be compared to age and education matched healthy adolescents. We will use taste and monetary reward stimuli and tasks that are related to brain dopamine function, together with functional ..
  35. Taste organs: formation and regulation
    Hongxiang Liu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Taste bud cells, the sensory end organs that transduce chemical stimuli into neural signals conveyed to the central nervous system, reside in taste papillae in the mammalian tongue...
  36. Exploring statins as a small molecule therapy for treatment of schistosomiasis
    Conor Caffrey; Fiscal Year: 2013
    ..In addition, the drug has a repellent taste and is marketed as a large 600 mg tablet making compliance, especially for children, difficult...
  37. Eph/Ephrin signaling in Taste Nerve Targeting
    MICHAEL WILLIAM ROCHLIN; Fiscal Year: 2010
    ..The discrete nature of taste papillae and the taste buds within their epithelium make it an excellent model for studying axon targeting ..
  38. PHYSIOLOGY OF CALCIUM APPETITE
    Michael G Tordoff; Fiscal Year: 2013
    ..has already implicated in the control of calcium consumption;the calcium-sensing receptor, Casr, and the sweet taste receptor, Tas1r3...
  39. African Diversity and the Genetics of Human Health
    Joseph P Jarvis; Fiscal Year: 2011
    ..adult height, weight, body mass index (BMI), blood glucose level, resting blood pressure, resting heart rate, taste perception (PTC, Salicin and SOA) and lactase persistence...
  40. Gene Regulation of Cranial Sensory Placode Development
    SALLY ANN MOODY; Fiscal Year: 2013
    ..can have a devastating effect on an individual, profoundly impairing the sense of smell, sight, hearing, balance, taste and somatothesis of the face...
  41. Human Umami Taste: Genetics of Psychophysical Traits
    Paul A S Breslin; Fiscal Year: 2012
    The umami taste of amino acids (especially glutamate) and sweetness are the two appetitive taste qualities that are critical for our healthy attraction to protein and carbohydrate (energy) macronutrients...
  42. Neuropeptide Modulation of Taste Signals
    Nirupa Chaudhari; Fiscal Year: 2010
    ..b>Taste strongly influences food selection...
  43. Role of taste signaling elements in enteroendocrine cells
    Robert F Margolskee; Fiscal Year: 2013
    ..by applicant): We have determined that gustducin, T1R3 and several other signaling elements that underlie taste detection/transduction also are expressed in L and K subtypes of enteroendocrine cells...
  44. Gustatory Control of Sodium Appetite
    Ralph Norgren; Fiscal Year: 2012
    ..simple, the sodium ion, and in the external environment, this stimulus is transduced by a single sensory system, taste. In most mammals, including humans, recognition of sodium is innate...
  45. Role of the TRPV1 channel in myocardial salvage from ischemia-reperfusion injury
    ERIC RICHARD GROSS; Fiscal Year: 2012
    ..Research: Chili peppers produce their hot spicy taste by the compound capsaicin, which in turn also releases endorphins (a probable reason why we are fond of spicy food)..
  46. Taste representations in the Drosophila brain
    KRISTIN E SCOTT; Fiscal Year: 2012
    The long-term goal of this proposal is to increase understanding of taste recognition and taste perception...
  47. Role of Parabrachial Nucleus Neuropeptides in Feeding
    John Paul Baird; Fiscal Year: 2011
    ..proposal will continue to evaluate the effects of NPY and MC receptor ligands on feeding and electrophysiological taste and visceral responses in the pontine parabrachial nucleus (PBN), a brainstem nucleus that receives significantly ..
  48. Advanced Research Training in Otolaryngology
    Marci M Lesperance; Fiscal Year: 2013
    ..likely to undertake research in the NIDCD mission areas of hearing, voice, communication disorders, neuroscience, taste, smell, and related cellular biology...
  49. Taste Receptor Genes and Sensory Coding
    HUBERT O AMREIN; Fiscal Year: 2013
    ..Behavioral and electrophysiological studies have indicted that Drosophila possesses a well-developed sense of taste that can detect a large number of chemically diverse substrates (ligands)...
  50. Engineering a Supplemental Phenylalanine Metabolic Pathway to Prevent mPKU
    Stephen K Hunter; Fiscal Year: 2011
    ..Some treated children still suffer mild cognitive defects. Main inhibitors of patient compliance include the foul taste, expense, and restrictiveness of the diet...
  51. The Role of Mpdz in Ethanol Withdrawal and Genetically Correlated Behaviors
    Kari J Buck; Fiscal Year: 2012
    ..e., acceptance drinking, conditioned taste aversion, ataxia sensitivity, and tolerance) that are genetically correlated with Mpdz status and expression, as ..
  52. Regressive evolution of pigmentation in the Mexican cavefish, Astyanax mexicanus
    Jessica A Lehoczky; Fiscal Year: 2010
    ..These isolated cave populations underwent rapid evolution of morphological traits such as increased numbers of taste buds and teeth, and the loss of pigmentation and eyes...
  53. Hedonic vs. Metabolic Processing by the Nucleus Accumbens
    James Edgar McCutcheon; Fiscal Year: 2013
    ..correlates of food reward are dependent on the presence of calories or the positive hedonic aspects of taste stimuli...
  54. SENSORY CODING IN TASTE
    John D Boughter; Fiscal Year: 2013
    ..The sense of taste is the most important factor in regulating these ingestive decisions, and therefore plays an important role in ..
  55. Impact of Receptor Polymorphisms on Sensations from Common Oral Irritants
    JOHN EDWARD HAYES; Fiscal Year: 2013
    ..chemosensory psychophysics, and molecular and quantitative behavioral genetics to examine how genetic variation in taste and pain receptors in the mouth may alter response to oral irritants that are commonly found in the food supply...
  56. The GE PETtrace Cyclotron: A Scientific Resource for the State of Arizona
    Eric M Reiman; Fiscal Year: 2010
    ..contributions to the study of memory, consciousness, emotion, temperature and pain sensation, hunger, satiation, taste and the predisposition to obesity, the role of PET in clinical oncology, the role of brain-mapping in ..
  57. A Total Synthesis of Gambierol Using an Epoxide-Opening Cascade Approach
    DENISE ANN COLBY; Fiscal Year: 2010
    ..ion channels, gambierol has been shown to inhibit voltage-gated potassium ion channels (Kv channels) in mouse taste cells...
  58. Functional Organization of the Central Gustatory System
    Alan C Spector; Fiscal Year: 2013
    ..and operculum, the site of primary gustatory cortex in humans, can alter the flow of ascending and descending taste-related information through the brain which has great potential to disrupt normal gustatory processing and can ..
  59. Counter-irritation by Menthol: Molecular Targets and Role in Airway Disease
    John B Morris; Fiscal Year: 2013
    ..The tobacco industry has added a wide range of chemicals to cigarettes to increase product stability and modify taste and sensory qualities of smoke...
  60. PD2024: A Peripherally Active TNFalpha inhibitor for the treatment of Obesity
    SOMASUNDAR PRASAD GABBITA; Fiscal Year: 2010
    ..Our Preliminary Studies demonstrate that our lead compound did not elicit any taste aversion...
  61. Effects of Acute and Chronic Alcohol on Brain Reward in Mice
    C J Malanga; Fiscal Year: 2013
    ..Alcohol self-administration in rodent models may be complicated by factors such as taste aversion and thirst that are avoided with ICSS, which allows a unique and novel approach to investigate the ..
  62. Agonist & Antagonist Activity and Binding on the TMD of hT1R3
    Marianna Max; Fiscal Year: 2010
    ..composed of the monomers T1R2 + T1R3, appears to be the main (and perhaps the only) receptor underlying sweet taste in humans...
  63. International collaborative research to develop quantitive sensory testing guidel
    Mark Drangsholt; Fiscal Year: 2009
    ..There is also growing evidence that, in addition to dysfunction of the trigeminal system, damage to taste fibers in the chorda tympani branch of the facial nerve may be related to oral pain conditions...
  64. CHORDA-LINGUAL NERVE INJURY AND CHEMOSENSORY PERFORMANCE
    John Zuniga; Fiscal Year: 1993
    ..The objective of this project is to evaluate the impact of severe chorda-lingual nerve injury on gustation and taste bud density, specifically the capacity of human subjects with unilateral nerve injury to detect and scale the ..
  65. Transmission of Taste Signals in Taste Buds
    Thomas E Finger; Fiscal Year: 2010
    b>Taste receptor cells transduce chemical signals into a neural message transmitted to the gustatory nerve fibers that innervate taste buds...
  66. Bitter taste phenotype as a risk factor of oral nicotine replacement nonadherence
    Karen L Ahijevych; Fiscal Year: 2010
    Bitter taste phenotype as a risk factor of oral nicotine replacement nonadherence The broad objective of this exploratory experiment is to generate data on the interaction of bitter taste phenotype and use of oral nicotine replacement ..
  67. NALTREXONE AND ALCOHOL REACTIVITY
    STEPHEN KIEFER; Fiscal Year: 2000
    b>Taste represents an important factor in the decision to ingest substances, including alcohol...
  68. Cellulose-Based Strips for Human Taste Evaluation
    Lloyd Hastings; Fiscal Year: 2010
    b>Taste disorders have significant consequences for humans, and these consequences include impaired quality of life, increased health or safety risks from spoiled foods, compromised vocational abilities, and altered food choices and ..
  69. TASTE LOSS FROM RADIATION THERAPY IN CANCER PATIENTS
    GINA NELSON; Fiscal Year: 2003
    Background and Significance: Post-irradiation gustatory dysfunction is the loss of taste following radiation of the mouth for treatment of cancer. It is often accompanied by mucositis and xerostomia...
  70. Embryonic development of taste buds.
    LINDA BARLOW; Fiscal Year: 2009
    b>Taste buds are multicellular receptor organs of the gustatory system, and are innervated by a discrete set of cranial nerves...
  71. SALT TASTE TRANSDUCTION AND ITS HORMONAL REGULATION
    TIMOTHY GILBERTSON; Fiscal Year: 1999
    ..work is to determine the mechanisms involved in the transduction of salts in the fungiform and circumvallate taste receptors cells and the regulation of salt transducing elements by the peptide hormones arginine vasopressin and ..
  72. HUMAN CHEMOSENSORY PERFORMANCE AND TASTE BUD DENSITY
    ROBERT ENGLEHARDT; Fiscal Year: 1993
    The objective of this project is to measure detection thresholds and operative scales of citrate taste judgement within spatially-matched, isolated, discrete regions of the anterior tongue tip in neurologically normal individuals...
  73. Cellulose-Based Strips for Human Taste Evaluation
    Lloyd Hastings; Fiscal Year: 2004
    ..e., "edible film strips", as a substrate for delivery of taste stimuli to the oral cavity...
  74. DOPAMINE AND GUSTATORY-VISCEROMOTOR INTEGRATION
    Barry Davis; Fiscal Year: 1999
    ..adapted from the applicants abstract): The gustatory system is responsible for the conscious awareness of taste quality...