smell

Summary

Summary: The sensation or perception of scents or odors.

Top Publications

  1. ncbi Or83b encodes a broadly expressed odorant receptor essential for Drosophila olfaction
    Mattias C Larsson
    Laboratory of Neurogenetics and Behavior, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuron 43:703-14. 2004
  2. ncbi Soluble proteins in insect chemical communication
    P Pelosi
    Dipartimento di Chimica e Biotecnologie Agrarie, University of Pisa Italy, Agrarie via S Michele, 4, 56124, Pisa, Italy
    Cell Mol Life Sci 63:1658-76. 2006
  3. ncbi Drosophila OBP LUSH is required for activity of pheromone-sensitive neurons
    Pingxi Xu
    Department of Pharmacology, Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75335, USA
    Neuron 45:193-200. 2005
  4. ncbi A single class of olfactory neurons mediates behavioural responses to a Drosophila sex pheromone
    Amina Kurtovic
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nature 446:542-6. 2007
  5. pmc Non-synaptic inhibition between grouped neurons in an olfactory circuit
    Chih Ying Su
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Nature 492:66-71. 2012
  6. ncbi Molecular, anatomical, and functional organization of the Drosophila olfactory system
    Africa Couto
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3 5 A 1030 Vienna, Austria
    Curr Biol 15:1535-47. 2005
  7. ncbi Insect olfactory receptors are heteromeric ligand-gated ion channels
    Koji Sato
    Department of Integrated Biosciences, The University of Tokyo, Chiba 277 8562, Japan
    Nature 452:1002-6. 2008
  8. ncbi The molecular basis of odor coding in the Drosophila antenna
    Elissa A Hallem
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Cell 117:965-79. 2004
  9. ncbi Normative data for the "Sniffin' Sticks" including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects
    T Hummel
    Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, 01307, Dresden, Germany
    Eur Arch Otorhinolaryngol 264:237-43. 2007
  10. ncbi Evolution of insect olfaction
    Bill S Hansson
    Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Hans Knoell Strasse 8, 07749 Jena, Germany
    Neuron 72:698-711. 2011

Detail Information

Publications374 found, 100 shown here

  1. ncbi Or83b encodes a broadly expressed odorant receptor essential for Drosophila olfaction
    Mattias C Larsson
    Laboratory of Neurogenetics and Behavior, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuron 43:703-14. 2004
    ..Consistent with this cellular defect, the Or83b mutation disrupts behavioral and electrophysiological responses to many odorants. Or83b therefore encodes an atypical odorant receptor that plays an essential general role in olfaction...
  2. ncbi Soluble proteins in insect chemical communication
    P Pelosi
    Dipartimento di Chimica e Biotecnologie Agrarie, University of Pisa Italy, Agrarie via S Michele, 4, 56124, Pisa, Italy
    Cell Mol Life Sci 63:1658-76. 2006
    ..Finally, we discuss current ideas and models of the role of such proteins in insect chemoreception...
  3. ncbi Drosophila OBP LUSH is required for activity of pheromone-sensitive neurons
    Pingxi Xu
    Department of Pharmacology, Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75335, USA
    Neuron 45:193-200. 2005
    ..These studies directly link pheromone-induced behavior with OBP-dependent activation of a subset of olfactory neurons...
  4. ncbi A single class of olfactory neurons mediates behavioural responses to a Drosophila sex pheromone
    Amina Kurtovic
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nature 446:542-6. 2007
    ..Thus, activation of a single ORN class is both necessary and sufficient to mediate behavioural responses to the Drosophila sex pheromone cVA...
  5. pmc Non-synaptic inhibition between grouped neurons in an olfactory circuit
    Chih Ying Su
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Nature 492:66-71. 2012
    ..Finally, a CO(2)-sensitive ORN in the malaria mosquito Anopheles can also be inhibited by excitation of an adjacent ORN, suggesting a broad occurrence of lateral inhibition in insects and possible applications in insect control...
  6. ncbi Molecular, anatomical, and functional organization of the Drosophila olfactory system
    Africa Couto
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3 5 A 1030 Vienna, Austria
    Curr Biol 15:1535-47. 2005
    ..A comprehensive understanding of the molecular and neural mechanisms of odor detection and processing requires complete maps of odorant receptor (Or) expression and ORN connectivity, preferably at single-cell resolution...
  7. ncbi Insect olfactory receptors are heteromeric ligand-gated ion channels
    Koji Sato
    Department of Integrated Biosciences, The University of Tokyo, Chiba 277 8562, Japan
    Nature 452:1002-6. 2008
    ..The ligand-gated ion channel formed by an insect OR complex seems to be the basis for a unique strategy that insects have acquired to respond to the olfactory environment...
  8. ncbi The molecular basis of odor coding in the Drosophila antenna
    Elissa A Hallem
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Cell 117:965-79. 2004
    ..Receptors vary widely in their breadth of tuning, and odorants vary widely in the number of receptors they activate. Together, these properties provide a molecular basis for odor coding by the receptor repertoire of an olfactory organ...
  9. ncbi Normative data for the "Sniffin' Sticks" including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects
    T Hummel
    Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, 01307, Dresden, Germany
    Eur Arch Otorhinolaryngol 264:237-43. 2007
    ..Further, the present data suggest specific changes of individual olfactory functions in relation to age, with odor thresholds declining most dramatically compared to odor discrimination and odor identification...
  10. ncbi Evolution of insect olfaction
    Bill S Hansson
    Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Hans Knoell Strasse 8, 07749 Jena, Germany
    Neuron 72:698-711. 2011
    ....
  11. pmc The cell biology of smell
    Shannon DeMaria
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, USA
    J Cell Biol 191:443-52. 2010
    ..of G protein-coupled receptors-the odorant receptors-which are the chemical sensors underlying the perception of smell. Interestingly, the odorant receptors are also involved in a number of developmental decisions, including the ..
  12. ncbi An essential role for a CD36-related receptor in pheromone detection in Drosophila
    Richard Benton
    Laboratory of Neurogenetics and Behaviour, The Rockefeller University, 1230 York Avenue, Box 63, New York, New York 10065, USA
    Nature 450:289-93. 2007
    ....
  13. ncbi Visualizing an olfactory sensory map
    P Mombaerts
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute and Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Cell 87:675-86. 1996
    ..This genetic approach may be more broadly applied to visualize the development and plasticity of projections in the mammalian nervous system...
  14. ncbi Speed and accuracy of olfactory discrimination in the rat
    Naoshige Uchida
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nat Neurosci 6:1224-9. 2003
    The sense of smell is typically thought of as a 'slow' sense, but the true temporal constraints on the accuracy of olfactory perception are not known...
  15. ncbi Genetic variation in a human odorant receptor alters odour perception
    Andreas Keller
    Laboratory of Neurogenetics and Behaviour, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
    Nature 449:468-72. 2007
    ..Our results demonstrate the first link between the function of a human odorant receptor in vitro and odour perception...
  16. ncbi Insect odor and taste receptors
    Elissa A Hallem
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Annu Rev Entomol 51:113-35. 2006
    ..Here we discuss recent advances in our understanding of the molecular and cellular basis of odor and taste coding in insects...
  17. pmc Divisive normalization in olfactory population codes
    Shawn R Olsen
    Harvard Medical School, Department of Neurobiology, Boston, MA 02115, USA
    Neuron 66:287-99. 2010
    ....
  18. pmc Receptors and neurons for fly odors in Drosophila
    Wynand Van der Goes van Naters
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520 8103, USA
    Curr Biol 17:606-12. 2007
    ..We propose a model describing how these receptors might be used by a male to distinguish suitable from unsuitable mating partners through a simple logic...
  19. pmc A large-scale analysis of odor coding in the olfactory epithelium
    Kiyomitsu Nara
    Howard Hughes Medical Institute, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Neurosci 31:9179-91. 2011
    ....
  20. ncbi RTP family members induce functional expression of mammalian odorant receptors
    Harumi Saito
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA
    Cell 119:679-91. 2004
    ..We have used this approach to identify active odorant ligands for ORs, providing a platform for screening the chemical selectivity of the large OR family...
  21. pmc Odor coding by a Mammalian receptor repertoire
    Harumi Saito
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA
    Sci Signal 2:ra9. 2009
    ..Our results provide a basis for translating odorants into receptor neuron responses and for unraveling mammalian odor coding...
  22. ncbi Enriched odor exposure increases the number of newborn neurons in the adult olfactory bulb and improves odor memory
    Christelle Rochefort
    Perception and Memory Laboratory, Centre National de la Recherche Scientifique Unité de Recherche Associée 2182, Institut Pasteur, 75 724 Paris Cedex 15, France
    J Neurosci 22:2679-89. 2002
    ..By maintaining a constitutive turnover of granule cells subjected to modulation by environmental cues, ongoing bulbar neurogenesis could be associated with improved olfactory memory...
  23. pmc Cellular-resolution population imaging reveals robust sparse coding in the Drosophila mushroom body
    Kyle S Honegger
    Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 31:11772-85. 2011
    ..Our results indicate that the fundamental feature of odor processing in the MB is to create sparse stimulus representations in a format that facilitates arbitrary associations between odor and punishment or reward...
  24. pmc Molecular vibration-sensing component in Drosophila melanogaster olfaction
    Maria Isabel Franco
    Institute of Cellular and Developmental Biology, Biomedical Sciences Research Centre Alexander Fleming, Vari 16672, Greece
    Proc Natl Acad Sci U S A 108:3797-802. 2011
    ..These findings are inconsistent with a shape-only model for smell, and instead support the existence of a molecular vibration-sensing component to olfactory reception.
  25. pmc The olfactory co-receptor Orco from the migratory locust (Locusta migratoria) and the desert locust (Schistocerca gregaria): identification and expression pattern
    Ying Yang
    China Agricultural University, Key Lab for Biological Control of the Ministry of Agriculture, Beijing, China
    Int J Biol Sci 8:159-70. 2012
    ..Together, the results support the notion for a decisive role of Orco in locust olfaction...
  26. ncbi Olfactory signalling in vertebrates and insects: differences and commonalities
    U Benjamin Kaupp
    Center of Advanced European Studies and Research, Ludwig Erhard Allee 2, Bonn, Germany
    Nat Rev Neurosci 11:188-200. 2010
    ..Metabotropic signalling in vertebrates provides a rich panoply of positive and negative regulation, whereas ionotropic signalling in insects enhances processing speed...
  27. pmc ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification
    Aaron B Stephan
    Department of Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 106:11776-81. 2009
    ..Considering these findings together, we propose that ANO2 constitutes the olfactory calcium-activated chloride channel...
  28. pmc Gamma neurons mediate dopaminergic input during aversive olfactory memory formation in Drosophila
    Hongtao Qin
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Curr Biol 22:608-14. 2012
    ..We argue that DA-mediated CS-US association is formed in γ neurons followed by communication between γ and α/β neurons to drive consolidation...
  29. ncbi Simultaneous activation of mouse main and accessory olfactory bulbs by odors or pheromones
    Fuqiang Xu
    Department of Diagnostic Radiology, Yale Medical School, New Haven, Connecticut 06520, USA
    J Comp Neurol 489:491-500. 2005
    ....
  30. ncbi Robust odor coding via inhalation-coupled transient activity in the mammalian olfactory bulb
    Kevin M Cury
    Department of Molecular and Cellular Biology, Harvard University, Center for Brain Science, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Neuron 68:570-85. 2010
    ..These results suggest that inhalation-coupled transient activity forms a robust neural code that is invariant to changes in respiration behavior...
  31. pmc Cellular and behavioral effects of cranial irradiation of the subventricular zone in adult mice
    Francoise Lazarini
    Institut Pasteur, Laboratory for Perception and Memory, Paris, France
    PLoS ONE 4:e7017. 2009
    ..Thousands of new neurons appear each day, but the function of this ongoing neurogenesis remains unclear...
  32. ncbi Naris occlusion alters the electro-olfactogram: evidence for compensatory plasticity in the olfactory system
    Christopher T Waggener
    Department of Biology, Randolph Macon College, Ashland, VA 23005, USA
    Neurosci Lett 427:112-6. 2007
    ..These results provide the most direct support, to date, for compensatory plasticity in the olfactory system...
  33. pmc Lateral presynaptic inhibition mediates gain control in an olfactory circuit
    Shawn R Olsen
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 452:956-60. 2008
    ..A substantial portion of this interglomerular inhibition acts at a presynaptic locus, and our results imply that this is mediated by both ionotropic and metabotropic receptors on the same nerve terminal...
  34. pmc Critical period for sensory experience-dependent survival of newly generated granule cells in the adult mouse olfactory bulb
    Masahiro Yamaguchi
    Department of Physiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 102:9697-702. 2005
    ..These results indicate that there is a critical period when the survival of new granule cells is determined in a sensory experience-dependent manner and that the pharmacological manipulation can mimic the effect of sensory deprivation...
  35. ncbi A metric for odorant comparison
    Rafi Haddad
    Department of Neurobiology, Weizmann Institute of Science, Hertzel, Rehovot 76100 Israel
    Nat Methods 5:425-9. 2008
    ..We use this new metric to recommend sets of odorants that span the physicochemical space for use in olfaction experiments...
  36. pmc Effect of sniffing on the temporal structure of mitral/tufted cell output from the olfactory bulb
    Ryan M Carey
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 31:10615-26. 2011
    ....
  37. ncbi Modification of CO2 avoidance behaviour in Drosophila by inhibitory odorants
    Stephanie Lynn Turner
    Cellular, Molecular, and Developmental Biology Program, University of California, Riverside, California 92521, USA
    Nature 461:277-81. 2009
    ..Our findings have broader implications in highlighting the important role of inhibitory odorants in olfactory coding, and in their potential to disrupt CO(2)-mediated host-seeking behaviour in disease-carrying insects like mosquitoes...
  38. ncbi Oscillations and sparsening of odor representations in the mushroom body
    Javier Perez-Orive
    Division of Biology, 139 74, California Institute of Technology, Pasadena, CA 91125, USA
    Science 297:359-65. 2002
    ..These results provide direct support for the functional relevance of correlation codes and shed some light on the role of oscillatory synchronization in sensory networks...
  39. ncbi Maintaining accuracy at the expense of speed: stimulus similarity defines odor discrimination time in mice
    Nixon M Abraham
    WIN Group of Olfactory Dynamics, Heidelberger Akademie der Wissenschaften and Max Planck Institut für medizinische Forschung, Jahnstrasse 29, D 69120 Heidelberg, Germany
    Neuron 44:865-76. 2004
    ..The fine discrimination of highly similar stimuli, however, requires temporal integration of activity, suggesting a tradeoff between accuracy and speed...
  40. ncbi Microarray-based survey of a subset of putative olfactory genes in the mosquito Anopheles gambiae
    H Biessmann
    Developmental Biology Center, University of California, Irvine, CA 92697, USA
    Insect Mol Biol 14:575-89. 2005
    ....
  41. pmc Relational representation in the olfactory system
    Thomas A Cleland
    Department of Neurobiology and Behavior, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 104:1953-8. 2007
    ..We show that global feed-forward normalization in a sensory system is behaviorally relevant, and that a center-surround neural architecture does not necessarily imply center-surround function...
  42. pmc A direct main olfactory bulb projection to the 'vomeronasal' amygdala in female mice selectively responds to volatile pheromones from males
    Ningdong Kang
    Department of Biology, Boston University, Boston, MA 02215, USA
    Eur J Neurosci 29:624-34. 2009
    ..The presence of a direct MOB-to-medial amygdala pathway in mice and other mammals could enable volatile, opposite-sex pheromones to gain privileged access to diencephalic structures that control mate recognition and reproduction...
  43. pmc Odor coding in the maxillary palp of the malaria vector mosquito Anopheles gambiae
    Tan Lu
    Department of Biological Sciences, Center for Molecular Neuroscience, Institute of Chemical Biology and Global Health and Program in Developmental Biology, Vanderbilt University, Nashville, Tennessee 37235, USA
    Curr Biol 17:1533-44. 2007
    ..However, the molecular and cellular basis of such olfactory responses remains largely unknown...
  44. ncbi Identification of receptors of main sex-pheromone components of three Lepidopteran species
    Hidefumi Mitsuno
    Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
    Eur J Neurosci 28:893-902. 2008
    ....
  45. pmc A highly conserved candidate chemoreceptor expressed in both olfactory and gustatory tissues in the malaria vector Anopheles gambiae
    R Jason Pitts
    Department of Biological Sciences, Center for Molecular Neuroscience and Program in Developmental Biology, Vanderbilt University, Nashville, TN 37235, USA
    Proc Natl Acad Sci U S A 101:5058-63. 2004
    ..The biting and host preference behavior of this disease vector is largely influenced by its sense of smell, which is presumably facilitated by G protein-coupled receptor signaling [Takken, W. & Knols, B. (1999) Annu...
  46. pmc An Expressed Sequence Tag collection from the male antennae of the Noctuid moth Spodoptera littoralis: a resource for olfactory and pheromone detection research
    Fabrice Legeai
    1IRISA, Equipe Symbiose, Campus Universitaire de Beaulieu, 35042 Rennes Cedex, France
    BMC Genomics 12:86. 2011
    ..Here, we describe an Expressed Sequence Tag (EST) project to characterize the antennal transcriptome of the noctuid pest model, Spodoptera littoralis, and to identify candidate genes involved in odour/pheromone detection...
  47. pmc A presynaptic gain control mechanism fine-tunes olfactory behavior
    Cory M Root
    Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 59:311-21. 2008
    ..These findings indicate that different olfactory receptor channels employ heterogeneous presynaptic gain control as a mechanism to allow an animal's innate behavioral responses to match its ecological needs...
  48. ncbi A novel multigene family may encode odorant receptors: a molecular basis for odor recognition
    L Buck
    Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    Cell 65:175-87. 1991
    ..The members of this novel gene family are likely to encode a diverse family of odorant receptors...
  49. ncbi Serotonin is critical for rewarded olfactory short-term memory in Drosophila
    Divya Sitaraman
    Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA
    J Neurogenet 26:238-44. 2012
    ..Thus, serotonin appears to have a more general role in Drosophila memory, and implies an interaction with both the dopaminergic and octopaminergic systems...
  50. ncbi Olfaction: diverse species, conserved principles
    Barry W Ache
    Whitney Lab for Marine Bioscience, Department of Zoology, Center for Smell and Taste and McKnight Brain Institute, University of Florida, Gainesville, Florida 32610, USA
    Neuron 48:417-30. 2005
    ..These common features span a phylogenetically broad array of animals, implying that there is an optimal solution to the problem of detecting and discriminating odors...
  51. ncbi The sniff as a unit of olfactory processing
    Adam Kepecs
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Chem Senses 31:167-79. 2006
    ..Further electrophysiological recordings in behaving animals will be necessary to assess these proposals...
  52. ncbi Interneurons produced in adulthood are required for the normal functioning of the olfactory bulb network and for the execution of selected olfactory behaviors
    Vincent Breton-Provencher
    Cellular Neurobiology Unit, Centre de Recherche Universite Laval Robert Giffard, Quebec, Quebec G1J 2G3, Canada
    J Neurosci 29:15245-57. 2009
    ..Altogether, our data highlight the importance of adult neurogenesis for the proper functioning of the OB network and imply that new bulbar interneurons are involved in some, but not all, odor-associated tasks...
  53. pmc Diversity and wiring variability of olfactory local interneurons in the Drosophila antennal lobe
    Ya Hui Chou
    Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, California, USA
    Nat Neurosci 13:439-49. 2010
    ..Our results reveal an unexpected degree of complexity and individual variation in an invertebrate neural circuit, a result that creates challenges for solving the Drosophila connectome...
  54. ncbi Olfactory coding with patterns of response latencies
    Stephan Junek
    Department of Neurophysiology and Cellular Biophysics, University of Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    Neuron 67:872-84. 2010
    ..Our results suggest that the latency patterns of M/T cells contain all the information higher brain centers need to identify odors and their concentrations...
  55. ncbi Olfaction: mosquito receptor for human-sweat odorant
    Elissa A Hallem
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Nature 427:212-3. 2004
    ..Compounds designed to activate or block receptors of this type could function as attractants for trapping mosquitoes or as insect repellents in helping to control Anopheles and other insect pests...
  56. pmc Rapid evolution of smell and taste receptor genes during host specialization in Drosophila sechellia
    Carolyn S McBride
    Center for Population Biology, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 104:4996-5001. 2007
    ....
  57. pmc Controversy and consensus: noncanonical signaling mechanisms in the insect olfactory system
    Takao Nakagawa
    Laboratory of Neurogenetics and Behavior, The Rockefeller University, New York, NY 10065, USA
    Curr Opin Neurobiol 19:284-92. 2009
    ..Here we consider all the evidence and offer a consensus model for a noncanonical mechanism of olfactory signal transduction in insects...
  58. pmc Olfactory deficits in mice overexpressing human wildtype alpha-synuclein
    Sheila M Fleming
    Department of Neurology and Neurobiology, The David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Eur J Neurosci 28:247-56. 2008
    ..Furthermore, the buried pellet and block tests provided sufficient power for the detection of a 50% drug effect, indicating their usefulness for testing novel neuroprotective therapies...
  59. ncbi Intensity versus identity coding in an olfactory system
    Mark Stopfer
    California Institute of Technology, Division of Biology, Computation and Neural Systems Program, Pasadena, CA 91125, USA
    Neuron 39:991-1004. 2003
    ..The tuning of KCs to identity and concentration and the patterning of their responses are consistent with piecewise decoding of their PN inputs over oscillation-cycle length epochs...
  60. ncbi A pheromone receptor mediates 11-cis-vaccenyl acetate-induced responses in Drosophila
    Tal Soo Ha
    Department of Pharmacology and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 26:8727-33. 2006
    ..Here, we show LUSH are also required in non-T1 neurons misexpressing the receptor to respond to VA. These data provide new insight into the molecular components and neuronal basis of volatile pheromone perception...
  61. ncbi Synaptic inhibition in the olfactory bulb accelerates odor discrimination in mice
    Nixon M Abraham
    Institute of Anatomy and Cell Biology, University of Heidelberg, INF 307, 69120 Heidelberg, Germany WIN Olfactory Dynamics Group, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
    Neuron 65:399-411. 2010
    ..Thus, spatiotemporally defined molecular perturbations of olfactory bulb granule cells directly link stimulus similarity, neuronal processing time, and discrimination behavior to synaptic inhibition...
  62. ncbi Association of olfactory dysfunction with risk for future Parkinson's disease
    G Webster Ross
    Veterans Affairs Pacific Islands Health Care System, University of Hawaii John A Burns School of Medicine, Honolulu, HI 96819, USA
    Ann Neurol 63:167-73. 2008
    ..This study examines the association of olfactory dysfunction with future development of PD in Honolulu-Asia Aging Study cohort members..
  63. ncbi Subsystem organization of the mammalian sense of smell
    Steven D Munger
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Annu Rev Physiol 71:115-40. 2009
    ..An integrative approach that includes gene targeting methods, optical and electrophysiological recording, and behavioral analysis has helped to elucidate the functional significance of this subsystem organization for the sense of smell.
  64. pmc Chemotopic odorant coding in a mammalian olfactory system
    Brett A Johnson
    Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 4550, USA
    J Comp Neurol 503:1-34. 2007
    ..A critical analysis suggests that alternative coding mechanisms for odor quality, such as those based on temporal patterns of responses, enjoy little experimental support...
  65. pmc Characterization and coding of behaviorally significant odor mixtures
    Jeffrey A Riffell
    University of Arizona, Tucson, 85721, USA
    Curr Biol 19:335-40. 2009
    ....
  66. ncbi The neurobiology of insect olfaction: sensory processing in a comparative context
    JOSHUA P MARTIN
    Department of Neuroscience, College of Science, University of Arizona, 1040 East Fourth Street, Tucson, AZ 85721 0077, USA
    Prog Neurobiol 95:427-47. 2011
    ..We propose that this perspective is beneficial for insect olfactory neurobiology in particular and sensory neurobiology in general...
  67. pmc Mosquitoes smell and avoid the insect repellent DEET
    Zainulabeuddin Syed
    Honorary Maeda Duffey Laboratory, Department of Entomology, University of California Davis, 1 Shields Ave, Davis, CA 95616
    Proc Natl Acad Sci U S A 105:13598-603. 2008
    ..Our research shows that mosquitoes smell DEET directly and avoid it...
  68. ncbi Rapid and precise control of sniffing during olfactory discrimination in rats
    Adam Kepecs
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    J Neurophysiol 98:205-13. 2007
    ..These results demonstrate the speed and precision of control over respiration and its significance for olfactory behavioral performance...
  69. ncbi Dynamic ensemble odor coding in the mammalian olfactory bulb: sensory information at different timescales
    Brice Bathellier
    Flavour Perception Group, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne EPFL, CH 1015, Switzerland
    Neuron 57:586-98. 2008
    ..Our results also support suggestive analogies in the dynamics of odor representations between insects and mammals...
  70. ncbi Representation of odorants by receptor neuron input to the mouse olfactory bulb
    M Wachowiak
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Neuron 32:723-35. 2001
    ..Finally, odorant activation slopes could differ across glomeruli, and for different odorants activating the same glomerulus. These results imply a high degree of complexity in odorant representations at the level of olfactory bulb input...
  71. ncbi Is adult neurogenesis essential for olfaction?
    Francoise Lazarini
    Institut Pasteur, Laboratory for Perception and Memory, 75015 Paris, France
    Trends Neurosci 34:20-30. 2011
    ..In this review we highlight the role of network activity in shaping ongoing neurogenesis and, in turn, how the integration of adult-born neurons refines pre-existing network function, and consequently olfactory behavior...
  72. pmc Odor quality coding and categorization in human posterior piriform cortex
    James D Howard
    Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Nat Neurosci 12:932-8. 2009
    ..These findings substantiate theoretical models emphasizing the importance of distributed piriform templates for the perceptual reconstruction of odor object quality...
  73. ncbi Precision and diversity in an odor map on the olfactory bulb
    Edward R Soucy
    Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, 52 Oxford Street, Cambridge, Massachusetts 02138, USA
    Nat Neurosci 12:210-20. 2009
    ..This local diversity of sensory tuning stands in marked distinction from other brain maps. Given the reliable placement of the glomeruli, it represents a feature, not a flaw, of the olfactory bulb...
  74. ncbi Dynamic optimization of odor representations by slow temporal patterning of mitral cell activity
    R W Friedrich
    California Institute of Technology, Division of Biology, MC 139-74, Pasadena, CA 91125, USA
    Science 291:889-94. 2001
    ..This optimization of ensemble representations did not occur among olfactory afferents but resulted from OB circuit dynamics. Time can therefore gradually optimize stimulus representations in a sensory network...
  75. ncbi Molecular architecture of smell and taste in Drosophila
    Leslie B Vosshall
    Laboratory of Neurogenetics and Behavior, The Rockefeller University, New York, NY 10021 6399, USA
    Annu Rev Neurosci 30:505-33. 2007
    The chemical senses-smell and taste-allow animals to evaluate and distinguish valuable food resources from dangerous substances in the environment...
  76. pmc The missense of smell: functional variability in the human odorant receptor repertoire
    Joel D Mainland
    1 Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA 2 Department of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham North Carolina, USA 3 Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Nat Neurosci 17:114-20. 2014
    ....
  77. pmc SNMP is a signaling component required for pheromone sensitivity in Drosophila
    Xin Jin
    Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9111, USA
    Proc Natl Acad Sci U S A 105:10996-1001. 2008
    ..Therefore, pheromone perception in Drosophila should serve as an excellent model to elucidate the role of CD36 members in transmembrane signaling...
  78. ncbi Coding and synaptic processing of sensory information in the glomerular layer of the olfactory bulb
    Matt Wachowiak
    Department of Biology, Boston University, Boston, MA 02215, USA
    Semin Cell Dev Biol 17:411-23. 2006
    ..We speculate that odor representations and their postsynaptic processing are tuned to and shaped by the sniffing behavior of the animal...
  79. ncbi Aging results in reduced epidermal growth factor receptor signaling, diminished olfactory neurogenesis, and deficits in fine olfactory discrimination
    Emeka Enwere
    Genes and Development Research Group, Department of Cell Biology and Anatomy, University of Calgary Faculty of Medicine, Calgary, Alberta T2N 4N1, Canada
    J Neurosci 24:8354-65. 2004
    ..These results suggest that the impairment in fine olfactory discrimination with age may result from a reduction in EGF-dependent olfactory neurogenesis...
  80. pmc Sequential use of mushroom body neuron subsets during drosophila odor memory processing
    Michael J Krashes
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Neuron 53:103-15. 2007
    ....
  81. pmc Loss-of-function mutations in sodium channel Nav1.7 cause anosmia
    Jan Weiss
    Department of Physiology, University of Saarland School of Medicine, 66421 Homburg, Germany
    Nature 472:186-90. 2011
    ..Our study creates a mouse model of congenital general anosmia and provides new strategies to explore the genetic basis of the human sense of smell.
  82. ncbi Two distinct channels of olfactory bulb output
    Izumi Fukunaga
    Behavioural Neurophysiology, Max Planck Institute for Medical Research, Jahnstr 29, 69120 Heidelberg, Germany
    Neuron 75:320-9. 2012
    ..Thus, phase separation by inhibition forms the basis for two distinct channels of olfactory processing...
  83. pmc A pair of inhibitory neurons are required to sustain labile memory in the Drosophila mushroom body
    Jena L Pitman
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Curr Biol 21:855-61. 2011
    ..We propose that APL neurons provide widespread inhibition to stabilize and maintain synaptic specificity of a labile memory trace in a recurrent DPM and MB α'β' neuron circuit...
  84. ncbi Magic at the marketplace: Choice blindness for the taste of jam and the smell of tea
    Lars Hall
    Lund University Cognitive Science, Lund University, Sweden
    Cognition 117:54-61. 2010
    ..Even for remarkably different tastes like Cinnamon-Apple and bitter Grapefruit, or the smell of Mango and Pernod was no more than half of all trials detected, thus demonstrating considerable levels of choice ..
  85. pmc Sniffing out the contributions of the olfactory tubercle to the sense of smell: hedonics, sensory integration, and more?
    Daniel W Wesson
    Emotional Brain Institute, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neurosci Biobehav Rev 35:655-68. 2011
    ..Together, the information within this review highlights an understudied yet potentially critical component in central odor processing...
  86. pmc Biophysical mechanisms underlying olfactory receptor neuron dynamics
    Katherine I Nagel
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Neurosci 14:208-16. 2011
    ..However, in the presence of rapidly fluctuating natural stimuli, spiking simply increases the speed and sensitivity of encoding...
  87. ncbi Postnatal refinement of peripheral olfactory projections
    Dong Jing Zou
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Science 304:1976-9. 2004
    ..Persistence may be due, in part, to prolonged survival of olfactory sensory neurons...
  88. ncbi Odor detection in insects: volatile codes
    M de Bruyne
    Biological Sciences, Monash University, Clayton, Australia
    J Chem Ecol 34:882-97. 2008
    ..We promote a more integrated research approach that links molecular physiology of receptor neurons to the ecology of odorants...
  89. ncbi Human olfaction: from genomic variation to phenotypic diversity
    Yehudit Hasin-Brumshtein
    Department of Molecular Genetics and the Crown Human Genome Center, Weizmann Institute of Science, Rehovot 76100, Israel
    Trends Genet 25:178-84. 2009
    The sense of smell is a complex molecular device, encompassing several hundred olfactory receptor proteins (ORs)...
  90. ncbi Optical imaging of odorant representations in the mammalian olfactory bulb
    B D Rubin
    Howard Hughes Medical Institute, Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neuron 23:499-511. 1999
    ..These characteristics suggest that odorants and their concentrations can be encoded by distinct spatial patterns of glomerular activation...
  91. ncbi Localization of a short-term memory in Drosophila
    T Zars
    Theodor Boveri Institut für Biowissenschaften, Lehrstuhl fur Genetik, Biozentrum Am Hubland, D97074, Wurzburg, Germany
    Science 288:672-5. 2000
    ..This demonstrates that synaptic plasticity in a small brain region can be sufficient for memory formation...
  92. ncbi The olfactory bulb: coding and processing of odor molecule information
    K Mori
    Laboratory for Neuronal Recognition Molecules, Laboratory for Neurobiology of Synapse, Brain Science Institute, RIKEN, Wako, Saitama 351 0198, Japan
    Science 286:711-5. 1999
    ..They also mediate synchronized oscillatory discharges among specific combinations of output neurons and may contribute to the integration of signals from distinct odorant receptors in the olfactory cortex...
  93. ncbi The Drosophila larva as a model for studying chemosensation and chemosensory learning: a review
    Bertram Gerber
    Universitat Wurzburg, Biozentrum, Am Hubland, Lehrstuhl für Genetik und Neurobiologie, D 97074 Wurzburg, Germany
    Chem Senses 32:65-89. 2007
    ....
  94. ncbi Long-term fate and distribution of newborn cells in the adult mouse olfactory bulb: Influences of olfactory deprivation
    N Mandairon
    Laboratoire de Neurosciences et Systèmes Sensoriels, CNRS UMR 5020, Universite Claude Bernard Lyon 1, 50 avenue Tony Garnier, 6936, Lyon Cedex 07, France
    Neuroscience 141:443-51. 2006
    ..In addition, our data suggest a functional heterogeneity of neurogenesis within the granular layer...
  95. pmc Select Drosophila glomeruli mediate innate olfactory attraction and aversion
    Julia L Semmelhack
    Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA
    Nature 459:218-23. 2009
    ..Together, these results indicate that individual glomeruli, rather than the entire pattern of active glomeruli, mediate innate behavioural output...
  96. pmc Sniffing behavior of mice during performance in odor-guided tasks
    Daniel W Wesson
    Department of Biology, Boston University, Boston, MA 02215, USA
    Chem Senses 33:581-96. 2008
    ..These results show that mouse sniffing behavior is highly dynamic, varies with behavioral context, and is strongly modulated by olfactory as well as nonolfactory events...
  97. ncbi Smelling a single component of male sweat alters levels of cortisol in women
    Claire Wyart
    Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720, USA
    J Neurosci 27:1261-5. 2007
    ..Critically, this study identified a single component of sweat, androstadienone, as capable of exerting such influence. This result points to a potential role for synthetic human chemosignals in clinical applications...
  98. ncbi Vomeronasal organ detects odorants in absence of signaling through main olfactory epithelium
    Kien Trinh
    Molecular and Cellular Biology Program and Department of Pharmacology, University of Washington, Box 357750, 1959 NE Pacific St, Seattle, Washington 98195, USA
    Nat Neurosci 6:519-25. 2003
    ..These same odorants elicited electro-olfactogram transients in the VNO and MOE of wild-type mice, but only VNO responses in AC3-/- mice. This indicates that some odorants are detected through an AC3-independent pathway in the VNO...
  99. ncbi Maps of odorant molecular features in the Mammalian olfactory bulb
    Kensaku Mori
    Department of Physiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Physiol Rev 86:409-33. 2006
    ..The molecular-feature maps provide a basis for understanding how the olfactory cortex reads the odor maps of the OB...
  100. ncbi Sniffing controls an adaptive filter of sensory input to the olfactory bulb
    Justus V Verhagen
    Department of Biology, Boston University, 24 Cummington Street, Boston, Massachusetts 02215, USA
    Nat Neurosci 10:631-9. 2007
    ..Thus, sniffing controls an adaptive filter for detecting changes in the odor landscape. These data suggest an unexpected functional role for sniffing and show that sensory codes can be transformed by sampling behavior alone...
  101. ncbi Neural representation of olfactory mixtures in the honeybee antennal lobe
    Nina Deisig
    Research Centre for Animal Cognition, CNRS Université Paul Sabatier UMR 5169, 31062 Toulouse Cedex 04, France
    Eur J Neurosci 24:1161-74. 2006
    ..Thus, although a gain control system in the honeybee antennal lobe prevents saturation of the olfactory system, mixture representation follows essentially elemental rules...

Research Grants69

  1. Biology of IGFs in Bone
    Thomas L Clemens; Fiscal Year: 2013
    ..insulin-like growth factors evolved in lower animalsto enable a wide range of physiological processes including smell, food consumption, metabolism, growth, reproduction and dormancy...
  2. Safety signal learning in Rhesus monkeys following early life stressChallenge Ar
    MICHAEL NMN DAVIS; Fiscal Year: 2010
    ..Thus the sound of a car back firing or the smell of sulfur can lead to an intense fear reaction in Viet Nam veterans many years after combat, even in the safety of ..
  3. Multiple Mechanisms of Nasal Chemoreception
    Diego Restrepo; Fiscal Year: 2012
    ..In humans, disorders of the sense of smell are encountered in diseases such as Alzheimer's (Doty, 1991;Rawson, 2000), bipolar depression (Hahn et al...
  4. Regulation of Odorant Receptor Gene Expression
    Paul Feinstein; Fiscal Year: 2013
    ..The sense of smell is critically dependent on olfactory neurons that translate the chemical world to the brain...
  5. OLFACTORY RECEPTOR COPY NUMBER ASSOCIATION WITH AGE AT ONSET OF ALZHEIMER DISEASE
    Kinga Szigeti; Fiscal Year: 2013
    ..We will correlate the olfactory genotype and phenotype using the aCGH and the University of Pennsylvania Smell Identification Test (UPSIT) measure...
  6. Metagenomic profiling of oral polymicrobial flora in head and neck cancers
    Charis Eng; Fiscal Year: 2011
    ..remove the cancer have significant disfigurement and diminished quality of life, with impaired ability to swallow, smell, and hear...
  7. Effect of Baclofen on Alcohol Cue-Elicited Urges to Drink and Smoke
    GEORGE ANTHONY KENNA; Fiscal Year: 2011
    ..Attention to the sight and smell of cues and psychophysiological responses (heart rate, mean arterial pressure and salivation changes) will also be ..
  8. Treatment Implications of Trauma Memory Modulation for PTSD & Alcohol Dependence
    Michael E Saladin; Fiscal Year: 2010
    ..during a subsequent test session consisting of exposure to the trauma scripted imagery and also the sight and smell of the participant's preferred alcoholic beverage...
  9. Implementation of Microfluidic Automation for Large-Scale Searches of Olfactory N
    Albert Folch; Fiscal Year: 2012
    ..response of dissociated mouse olfactory sensory neurons (OSNs) to various odorants;we refer to this platform as "smell-on-a-chip platform"...
  10. Biomarkers to Guide Treatment and Improve Survival in Oral/Oropharyngeal Cancer
    Thomas E Carey; Fiscal Year: 2012
    ..on radical surgery and radiation are associated with profound functional morbidity affecting communication, taste, smell, swallowing, cosmesis, sense of self, and overall quality of life...
  11. Axon Guidance in the Olfactory System
    DIEGO JAVIER RODRIGUEZ-GIL; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Loss of the sense of smell is an early indicator of several major neurological diseases in humans including Alzheimer's disease, ..
  12. Disruption of Host-Seeking Behavior in Aedes and Culex Mosquitoes using Odorants
    Anandasankar Ray; Fiscal Year: 2013
    ..Mosquitoes find their human hosts using the sense of smell. The goal of the proposed research is to modify odor-guided host-seeking behavior of Aedes and Culex mosquitoes ..
  13. Trigeminal Mechanisms of Oral Irritation
    Earl Carstens; Fiscal Year: 2009
    ..g., cross-desensitization), and if humans can qualitatively discriminate between irritants independent of taste or smell cues. Specific Aim 2...
  14. Intraflagellar Transport Proteins in Mice
    Gregory J Pazour; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Receptors localized to cilia are fundamental to our senses of sight and smell, and receptors on primary cilia are used by most vertebrate cells to sense the extracellular environment...
  15. Fetal Nicotine Exposure and Chemosensory Plasticity
    Steven L Youngentob; Fiscal Year: 2010
    ..we propose, contribute to the risk of tobacco-related product use and abuse in adolescence because these products "smell and taste better"...
  16. Olfactory Coding in Mammals
    Minghong Ma; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Millions of people, especially the elderly, suffer from smell dysfunction, which poses a negative impact on their quality of life...
  17. Gene Regulation of Cranial Sensory Placode Development
    SALLY ANN MOODY; Fiscal Year: 2013
    ..or their common precursor tissue can have a devastating effect on an individual, profoundly impairing the sense of smell, sight, hearing, balance, taste and somatothesis of the face...
  18. Chronic Rhinosinusitis Integrative Studies Program (CRISP)
    Robert P Schleimer; Fiscal Year: 2013
    ..It involves inflammation of the paranasal sinuses that results in facial pain/pressure, nasal and sinus drainage, smell loss, and nasal obstruction...
  19. Vaginal Ring for Preventing Bacterial Vaginosis
    THOMAS RAY MOENCH; Fiscal Year: 2010
    ..are asymptomatic, and most women with symptomatic BV have only mild symptoms (increased discharge with a fishy smell)...
  20. Advanced Research Training in Otolaryngology
    Marci M Lesperance; Fiscal Year: 2013
    ..to undertake research in the NIDCD mission areas of hearing, voice, communication disorders, neuroscience, taste, smell, and related cellular biology...
  21. Molecular mechanisms of olfaction in mammals
    Linda B Buck; Fiscal Year: 2012
    ..Project Narrative The mechanisms that the brain uses to perceive the world around us and to learn and remember are unknown. We will investigate the mechanisms that underlie the sense of smell to gain insight into these questions.
  22. Mechanisms of Sensory Modulation of Aging in Drosophila
    Scott D Pletcher; Fiscal Year: 2013
    ..distinguished four of them, each linked with one of the four elements - vision with water, sound with air, smell with fire, and touch with earth...
  23. Chronic rhinosinusitis-associated olfactory loss
    Andrew P Lane; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The loss of the sense of smell is a common symptom of chronic rhinosinusitis (CRS) that markedly diminishes the quality of life of affected patients...
  24. Cognitive modulation of primary sensory processing in olfactory receptor neurons
    John P McGann; Fiscal Year: 2013
    ..g. do expected odors smell stronger than unexpected odors?) and whether the difference in neurotransmitter release from receptor neurons is ..
  25. Examining the neural circuit for an instinctive olfactory-induced behavior in lar
    Scott T Laughlin; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Olfaction-the sense of smell-is the major means though which we sense our chemical surroundings, and as such, it has a significant impact on quality of life...
  26. Olfactory Singaling, Cilia, and Sensory Disorders
    JEFFREY MARTENS; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE In the nose, neurons involved in smell have many cilia, hair-like projections into the nasal cavity, which contain all of the proteins responsible for ..
  27. Neural organization of odor coding in human piriform cortex
    Jay A Gottfried; Fiscal Year: 2010
    ..Why does one volatile organic compound "smell" like chocolate, and another like cheese? There has been little systematic research to address these questions...
  28. Identification of Novel Loci Interacting with the Kallmann Syndrome Gene Kal-1
    CARLOS ANTONIO DIAZ-BALZAC; Fiscal Year: 2013
    ..provided by applicant): Kallmann Syndrome is a hereditary condition characterized by anosmia (the inability to smell) and hypogonadotropic hypogonadism resulting in infertility...
  29. Modulation of Odorant Receptor Function
    Hiroaki Matsunami; Fiscal Year: 2013
    ..olfactory system provides crucial information that may contribute toward novel therapy for anosmic and hyposmic patients who have compromised sense of smell, and to reduce stress associated with malodor, improving their quality of life.
  30. Modulation of Olfactory Cilia
    Minghong Ma; Fiscal Year: 2013
    ..environmental signals into intracellular responses, cilia serve many critical functions including perception of smell. Recent years have witnessed rapid progress in understanding the cell biology and signal transduction events in ..
  31. Center-surround functional organization and respiratory modulation of lateral inh
    Matthew Phillips; Fiscal Year: 2012
    ..Processing in the OB plays an important role in many human diseases including obesity and anosmia (inability to smell) - the OB is also one of the first brain regions to show indications of Alzheimer's and Parkinson's ..
  32. Phosphatase Regulation of Olfactory Bulb Mitral Cell Activity
    Melissa Cavallin Johnson; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: Kv1.3 is an ion channel that regulates the sense of smell. Both Kv1...
  33. The architecture and development of a sensory processing circuit for smell
    KRISTIN KAY BALDWIN; Fiscal Year: 2013
    ..Here, we propose to examine the impact of neural activity on circuits involved in the sense of smell. In particular, we will study the circuits formed by the mitral and tufted (MT) neurons, which receive inputs from ..
  34. Optical Imaging of Olfactory Sensory Code Transformation
    Shin Nagayama; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE The sense of smell plays an important role in our daily life style involving flavor and fragrance appreciation...
  35. The Neuropeptide Control of Mosquito Host-Seeking Behavior
    Jeff Liesch; Fiscal Year: 2013
    ..mechanism by which Head Peptide-I may inhibit host-seeking behavior is to modulate the mosquito's ability to smell a human host...
  36. Evolution of vertebrate sensory genes
    Jianzhi Zhang; Fiscal Year: 2010
    ..These studies will also help understand human smell and taste variations and disorders.
  37. Dynamic changes in Olfactory Ensheathing Cell properties after neuronal loss
    Tanu Sharma; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The sense of smell contributes to quality of life and warns of dangers present in the environment...
  38. Hyposmia, Cholinergic Denervation and Incipient Cognitive Decline in PD
    NICOLAAS IDA BOHNEN; Fiscal Year: 2013
    ..Results of this project may provide the foundation for unique biomarker information to guide annual clinical smell test screening in clinical practice - a window to guide targeted intervention in subjects with a central ..
  39. Neural circuit mechanisms of odor localization in mice
    DAVID HENRY GIRE; Fiscal Year: 2013
    ..Mice are macrosmotic creatures, and employ their sense of smell to detect conspecifics, food, and predators at a distance...
  40. SENSORY MECHANISMS AND DISORDERS
    David C Kohrman; Fiscal Year: 2013
    ..and thereby fosters innovative training opportunities into mechanisms and disorders of hearing, balance, taste and smell. Cross-disciplinary integration is made possible by the training program through: a) introductory and advanced ..
  41. Mechanisms of pheromone signal transduction in C. elegans
    DANNA MINDY ZEIGER; Fiscal Year: 2010
    ..For a complete understanding of how humans smell, and how odors affect development and behavior, a thorough understanding of the mechanisms of detecting and ..
  42. Sensory Adapted Dental Environments to Enhance Oral Care for Children with Autism
    SHARON ANDREA CERMAK; Fiscal Year: 2012
    ..of dental visits such as exposure to bright fluorescent lighting, touch in or around the mouth, or the texture and smell of various oral care products...
  43. Understanding Susceptibility to Olfactory Decline in Aging
    Jayant M Pinto; Fiscal Year: 2013
    ..will involve analysis of several olfactory traits for identifying gene(s) involved in the decline of the sense of smell. Lastly, using available, high quality DNA specimens, I will replicate these genetic associations in NSHAP...
  44. Electrophysiological ensembles organization during alcohol cue-induced intake and
    DAVID NATHANIEL LINSENBARDT; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Environmental stimuli such as the taste, smell, and sight, of a favorite alcoholic drink can become salient cues that increase craving for alcohol and lead individuals to continue to drink to the ..
  45. Olfactory Proteins in the Kidney and Regulation of Glomerular Filtration Rate
    Jennifer L Pluznick; Fiscal Year: 2010
    ..We have found that the same proteins in your nose which allow you to smell are also present in the cells in your kidney which are responsible for monitoring urine flow...
  46. Genetics of Taste: A Flavor for Health -- Community Lab and Education Programs
    BRIDGET CROWLEY COUGHLIN; Fiscal Year: 2010
    ..Project partners include the University of Florida's Human Chemosensory Program at the Smell and Taste Center;the University of Colorado Health Science Center's Rocky Mountain Taste and Smell Center;..
  47. Disruption of Host-Seeking Behavior in Anopheles Gambiae Mosquitoes using Odorant
    Anandasankar Ray; Fiscal Year: 2012
    ..Since the mosquito relies primarily on the sense of smell to find a human host, the olfactory system is a prime target for development of strategies to disrupt contact ..
  48. Development and Testing of a Device for Enhancing Memory During Sleep
    Alexander F Butterwick; Fiscal Year: 2012
    ..This memory enhancement technique involves four steps. (1) First, a sensory cue such as a smell or sound is presented during learning...
  49. CHEMOSENSORY CLINICAL RESEARCH CENTER
    Gary Beauchamp; Fiscal Year: 2009
    ..It is devoted to the scientific examination of clinical disorders in taste, smell and chemical irritation...
  50. Therapeutic rescue of an olfactory ciliopathy
    JEREMY MCINTYRE; Fiscal Year: 2012
    ..that are affected by these ciliopathies is the olfactory system, leading to a reduction or loss in the ability to smell. Individual olfactory sensory neurons (OSNs) contain over 20 cilia that project into the olfactory mucosa and are ..
  51. Johns Hopkins Medicine Biomarker Discovery in Parkinson's Disease
    Ted M Dawson; Fiscal Year: 2013
    ..motor testing as well as assessments of many of the non-motor facets of PD, including cognition, sleep, and smell. Many of our study participants will have agreed to autopsy through their participation in the Johns Hopkins ..
  52. Taste, smell, and feeding behavior in autism: A quantitative traits study
    Loisa Bennetto; Fiscal Year: 2013
    ..Taste and smell are both critical for ingestive behaviors, and a growing literature documents high rates of restricted and ..
  53. Olfactory Evoked Potentials and Developmental Neuropathology in Schizophrenia
    Bruce I Turetsky; Fiscal Year: 2013
    ..b>Smell abnormalities may therefore be an "early warning sign" of disease onset...
  54. The University of Florida Biomedical Research Core Center for Smell and Taste
    Barry W Ache; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The existing University of Florida Center for Smell and Taste (UFCST) will provide the basis for a Biomedical Research Core Center for Smell and Taste at the University of Florida (Core Center)...
  55. HFE: A Genetic Determinant of Olfactory Mn Absorption and Toxicity
    Marianne Wessling Resnick; Fiscal Year: 2010
    ..we will study a mouse model of HFE-associated hemochromatosis to test whether absorption of inhaled manganese is altered, and whether HFE therefore promotes a greater susceptibility to damage to olfaction - the sense of smell.
  56. Dynamics of glomerular coding in the olfactory bulb
    DALE M WACHOWIAK; Fiscal Year: 2013
    ..The sense of smell presents unique problems to the nervous system in terms of stimulus detection, neural encoding and recognition of ..
  57. Perceptual Coding and Modulation of Odor Objects in the Human Brain
    Jay A Gottfried; Fiscal Year: 2013
    ..Currently little is known about the neural processing of "odor objects," that is, the quality or character of a smell (e.g., minty, floral) arising from an odorous object...
  58. Chronic imaging of odor-evoked activity in olfactory bulb circuits of awake mice
    Takaki Komiyama; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The sense of smell plays an important role in our quality of life. However, the mechanisms governing the processing and representation of olfactory information in the brain are not well understood...
  59. Trauma-Related Olfactory Cues in Posttraumatic Stress Disorder
    Bernadette Cortese; Fiscal Year: 2013
    ..The proposed investigation will advance knowledge about the smell abilities, as well as the psychophysiology and fMRI-measured neural activation of odor-cued anxiety in PTSD...
  60. Nonvisual Foot Examination for People with Diabetes and Visual Impairment
    Ann S Williams; Fiscal Year: 2012
    ..low-technology intervention, Multiple Senses and Foot Evaluation (Multi-SAFE) uses nonvisual senses (touch and smell) to make foot self-examination accessible to people with visual impairment...
  61. Enhancement of olfactory neuron survival and targeting via odorant exposure
    Eric H Holbrook; Fiscal Year: 2010
    ..In summary, this proposal determines the effect of repeated odorant exposure on the recovery of the sense of smell after injury...
  62. Stimulating Young Neuroscientists And Physiologists in Science Education (S.Y.N.A
    JARED JACKSON; Fiscal Year: 2012
    ..observe and then control, the activity levels in the regions of the brain that are responsible for sight, hearing, smell, touch, taste and movement...
  63. Psychophysics of Divalent Salts and Metallic Taste
    HARRY LAWLESS; Fiscal Year: 2006
    ..of divalent salts such as those of calcium and iron will add to the knowledge base in the senses of taste and smell and may help the engineering of foods and supplements with acceptable sensory properties...
  64. OLFACTION IN MULTIPLE SCLEROSIS
    RICHARD DOTY; Fiscal Year: 2001
    ..Indeed, a number of medical textbooks state that the sense of smell is spared in MS, erroneously assuming that the olfactory system is unmyelinated...
  65. Neural substrates of taste, smell and flavor in humans
    DANA SMALL; Fiscal Year: 2006
    ..Our second aim is to use fMRI to investigate brain correlates of simultaneous presentation of taste and smell versus independent presentation with either a taste or a smell...
  66. Multivariate Parkinson's Disease Prediction System
    DUSTIN HELDMAN; Fiscal Year: 2007
    ..will aid in early screening by objectively quantifying several key PD symptoms including motor features, sense of smell, sleep parameters, voice modulation, and other relevant neurological signs...
  67. Functional Assays of Anopheles Odorant Receptors
    Kevin Lee; Fiscal Year: 2002
    ..of human hosts by mosquitoes, are governed by the detection of chemical cues in the environment via the sense of smell, olfaction...
  68. CHEMICAL SENSORY IRRITATION--CONTRAST WITH OLFACTION
    J Cometto Muniz; Fiscal Year: 1999
    ..e., nasal and ocular trigeminal chemoreception) and of the sense of smell. In order to separate the trigeminal from the olfactory response of the nose, ocular and nasal detection ..
  69. Viral Infection in Lactobacilli: An Animal BV Model
    Lin Tao; Fiscal Year: 2004
    ..Although BV itself only has mild discomfort, such as discharge and fishy smell, BV is associated with two major health risks in women: preterm delivery and increased susceptibility to contract ..