Summary: The sensation of sound.

Top Publications

  1. doi Cetaceans on a molecular fast track to ultrasonic hearing
    Yang Liu
    School of Life Sciences, East China Normal University, Shanghai, China
    Curr Biol 20:1834-9. 2010
  2. ncbi High-frequency tinnitus without hearing loss does not mean absence of deafferentation
    Nathan Weisz
    Department of Psychology, University of Konstanz, Germany
    Hear Res 222:108-14. 2006
  3. pmc Parallel signatures of sequence evolution among hearing genes in echolocating mammals: an emerging model of genetic convergence
    K T J Davies
    School of Biological and Chemical Sciences, Queen Mary University of London, London, UK
    Heredity (Edinb) 108:480-9. 2012
  4. ncbi The functional significance of mu rhythms: translating "seeing" and "hearing" into "doing"
    Jaime A Pineda
    Department of Cognitive Science and Neuroscience, University of California, San Diego, La Jolla, CA 92037 0515, USA
    Brain Res Brain Res Rev 50:57-68. 2005
  5. ncbi Precise inhibition is essential for microsecond interaural time difference coding
    Antje Brand
    Max Planck Institute of Neurobiology, Am Klopferspitz 18a, 82152 Martinsried, Germany
    Nature 417:543-7. 2002
  6. pmc The LINC complex is essential for hearing
    Henning F Horn
    Institute of Medical Biology, A STAR, Singapore
    J Clin Invest 123:740-50. 2013
  7. doi The hearing gene Prestin unites echolocating bats and whales
    Ying Li
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Curr Biol 20:R55-6. 2010
  8. doi The neural basis of Drosophila gravity-sensing and hearing
    Azusa Kamikouchi
    Sensory Systems Laboratory, Institute of Zoology, University of Cologne, 50923 Cologne, Germany
    Nature 458:165-71. 2009
  9. doi Key functions for gap junctions in skin and hearing
    Claire A Scott
    Centre for Cutaneous Research, The Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK
    Biochem J 438:245-54. 2011
  10. ncbi Effects of hearing aid amplification and stimulus intensity on cortical auditory evoked potentials
    Curtis J Billings
    Department of Speech and Hearing Sciences, University of Washington, Seattle, WA 98105, USA
    Audiol Neurootol 12:234-46. 2007

Research Grants

  1. Can L-carnitine prevent drug-induced hearing loss?
    Gilda Kalinec; Fiscal Year: 2004
  2. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
  3. Targeting Inflammation for the Amelioration of Cisplatin-Hearing Loss
    Vickram Ramkumar; Fiscal Year: 2011
  4. Steroid Responsive Mechanisms in the Ear
    DENNIS ROYAL TRUNE; Fiscal Year: 2012
  5. Genetic Studies of Optic Atrophy
    Taosheng Huang; Fiscal Year: 2012
  6. Estrogen Modulation of Auditory Processing
    Raphael Pinaud; Fiscal Year: 2012
  7. Human middle-ear imaging, physiology, and biomechanics
    CHARLES RICHARD STEELE; Fiscal Year: 2013
  8. Transplatin: A Novel Agent to Mitigate Cisplatin Toxicity
    Vickram Ramkumar; Fiscal Year: 2013
  9. Predicting Bilirubin-induced Auditory Toxicity in Infants with Severe Jaundice
    Sanjiv B Amin; Fiscal Year: 2010
  10. Anti-Bacterial Innate Responses Enhance Paramyxovirus Replication
    Griffith D Parks; Fiscal Year: 2010

Detail Information

Publications386 found, 100 shown here

  1. doi Cetaceans on a molecular fast track to ultrasonic hearing
    Yang Liu
    School of Life Sciences, East China Normal University, Shanghai, China
    Curr Biol 20:1834-9. 2010
    ..Echolocation in toothed whales demands exceptional high-frequency hearing [3], and both echolocation and ultrasonic hearing have also evolved independently in bats [4, 5]...
  2. ncbi High-frequency tinnitus without hearing loss does not mean absence of deafferentation
    Nathan Weisz
    Department of Psychology, University of Konstanz, Germany
    Hear Res 222:108-14. 2006
    ..The absence of audiometrically detectable hearing loss however poses a challenge to this rather generalizing assumption...
  3. pmc Parallel signatures of sequence evolution among hearing genes in echolocating mammals: an emerging model of genetic convergence
    K T J Davies
    School of Biological and Chemical Sciences, Queen Mary University of London, London, UK
    Heredity (Edinb) 108:480-9. 2012
    ..in the Prestin gene among some bats and cetaceans suggest that parallel adaptations for high-frequency hearing have taken place during the evolution of echolocation...
  4. ncbi The functional significance of mu rhythms: translating "seeing" and "hearing" into "doing"
    Jaime A Pineda
    Department of Cognitive Science and Neuroscience, University of California, San Diego, La Jolla, CA 92037 0515, USA
    Brain Res Brain Res Rev 50:57-68. 2005
    ..processing function that links perception and action-specifically, the transformation of "seeing" and "hearing" into "doing...
  5. ncbi Precise inhibition is essential for microsecond interaural time difference coding
    Antje Brand
    Max Planck Institute of Neurobiology, Am Klopferspitz 18a, 82152 Martinsried, Germany
    Nature 417:543-7. 2002
    ..A computer model, simulating the response of a coincidence-detector neuron with bilateral excitatory inputs and a temporally precise contralateral inhibitory input, supports this conclusion...
  6. pmc The LINC complex is essential for hearing
    Henning F Horn
    Institute of Medical Biology, A STAR, Singapore
    J Clin Invest 123:740-50. 2013
    Hereditary hearing loss is the most common sensory deficit. We determined that progressive high-frequency hearing loss in 2 families of Iraqi Jewish ancestry was due to homozygosity for the protein truncating mutation SYNE4 c.228delAT...
  7. doi The hearing gene Prestin unites echolocating bats and whales
    Ying Li
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Curr Biol 20:R55-6. 2010
    ..substantially in many aspects [2], we here report the surprising finding that the bottlenose dolphin, a toothed whale, is clustered with microbats in the gene tree constructed using protein sequences encoded by the hearing gene Prestin.
  8. doi The neural basis of Drosophila gravity-sensing and hearing
    Azusa Kamikouchi
    Sensory Systems Laboratory, Institute of Zoology, University of Cologne, 50923 Cologne, Germany
    Nature 458:165-71. 2009
    ..Here we focus on two of the remaining and less understood prime sensory modalities: graviception and hearing. We show that the fly has implemented both sensory modalities into a single system, Johnston's organ, which ..
  9. doi Key functions for gap junctions in skin and hearing
    Claire A Scott
    Centre for Cutaneous Research, The Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK
    Biochem J 438:245-54. 2011
    ..3 and Cx31 which lead to skin disease and deafness. Functional studies with Cx proteins have given insights into disease-associated mechanisms and non-gap junctional roles for Cx proteins...
  10. ncbi Effects of hearing aid amplification and stimulus intensity on cortical auditory evoked potentials
    Curtis J Billings
    Department of Speech and Hearing Sciences, University of Washington, Seattle, WA 98105, USA
    Audiol Neurootol 12:234-46. 2007
    b>Hearing aid amplification can be used as a model for studying the effects of auditory stimulation on the central auditory system (CAS)...
  11. pmc The hearing gene Prestin reunites echolocating bats
    Gang Li
    School of Life Science, East China Normal University, Shanghai 200062, China
    Proc Natl Acad Sci U S A 105:13959-64. 2008
    ..Echolocating bats use ultrasound for orientation and hunting and possess the highest frequency hearing of all mammals...
  12. ncbi Recognition of speech in noise with new hearing instrument compression release settings requires explicit cognitive storage and processing capacity
    Catharina Foo
    Department of Behavioural Sciences and Learning, Linkoping University, Sweden
    J Am Acad Audiol 18:618-31. 2007
    ..capacity predicts the ability to benefit from specific compression release settings in non-linear digital hearing instruments...
  13. ncbi Electrical stimulation of the midbrain for hearing restoration: insight into the functional organization of the human central auditory system
    Hubert H Lim
    Otorhinolaryngology Department, Hannover Medical University, 30625 Hannover, Germany
    J Neurosci 27:13541-51. 2007
    The cochlear implant can restore speech perception in patients with sensorineural hearing loss. However, it is ineffective for those without an implantable cochlea or a functional auditory nerve...
  14. ncbi Seeing and hearing speech excites the motor system involved in speech production
    K E Watkins
    Cognitive Neuroscience Unit, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
    Neuropsychologia 41:989-94. 2003
    ..These results provide evidence that both auditory and visual speech perception facilitate the excitability of the motor system involved in speech production...
  15. pmc Directional hearing by linear summation of binaural inputs at the medial superior olive
    Marcel van der Heijden
    Department of Neuroscience, Erasmus MC, University Medical Center Rotterdam, 3000 DR Rotterdam, The Netherlands
    Neuron 78:936-48. 2013
    ..The inputs from both ears sum linearly, whereas spike probability depends nonlinearly on the size of synaptic inputs. This simple coincidence detection scheme thus makes accurate sound localization possible...
  16. ncbi Effects of round window dexamethasone on residual hearing in a Guinea pig model of cochlear implantation
    David P James
    Department of Otolaryngology, University of Melbourne, Parkville, Australia
    Audiol Neurootol 13:86-96. 2008
    ..Animals that did not receive beads acted as controls. Pure-tone auditory brainstem response thresholds were estimated before and after electrode insertion, and 1 and 4 weeks later. Selected cochlear histology was performed...
  17. doi The remarkable cochlear amplifier
    J Ashmore
    Department of Neuroscience, Physiology and Pharmacology and UCL Ear Institute, Gower Street, London WC1E 6BT, UK
    Hear Res 266:1-17. 2010
    ..These experiments are presently lacking but if successfully performed would have an enormous impact on our understanding of the cochlear amplifier...
  18. ncbi Hearing visual motion in depth
    Norimichi Kitagawa
    Department of Psychology, Tokyo Metropolitan University, 1 1, Minami Osawa, Hachioji shi, Tokyo 192 0397, Japan
    Nature 416:172-4. 2002
    ..The results provide psychophysical evidence that, for processing of motion in depth, the auditory system responds to both auditory changing intensity and visual motion in depth...
  19. ncbi A TRPV family ion channel required for hearing in Drosophila
    Janghwan Kim
    Department of Genetics, Hanwha Chemical Co R and D Center, Sinsung dong, Yusung Gu, Daejeon 305 345, Korea
    Nature 424:81-4. 2003
    ..Antennal sound-evoked potentials are completely absent in mutants lacking Nan, showing that it is an essential component of the chordotonal mechanotransducer...
  20. pmc Structural determinants of cadherin-23 function in hearing and deafness
    Marcos Sotomayor
    Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Neuron 66:85-100. 2010
    ..The structures define an uncharacterized cadherin family and, with simulations, suggest mechanisms underlying inherited deafness and how cadherin-23 may bind with itself and with protocadherin-15 to form the tip link...
  21. pmc Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma
    Kunio Mizutari
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02115, USA
    Neuron 77:58-69. 2013
    b>Hearing loss due to damage to auditory hair cells is normally irreversible because mammalian hair cells do not regenerate...
  22. ncbi Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier
    M Charles Liberman
    Department of Otology and Laryngology, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Nature 419:300-4. 2002
    b>Hearing sensitivity in mammals is enhanced by more than 40 dB (that is, 100-fold) by mechanical amplification thought to be generated by one class of cochlear sensory cells, the outer hair cells...
  23. ncbi The sensory and motor roles of auditory hair cells
    Robert Fettiplace
    Department of Physiology, University of Wisconsin Medical School, 185 Medical Sciences Building, 1300 University Avenue, Madison, Wisconsin 53706, USA
    Nat Rev Neurosci 7:19-29. 2006
    ..Both motor mechanisms are probably needed to provide the high sensitivity and frequency discrimination of the mammalian cochlea...
  24. pmc Hearing lips and seeing voices: how cortical areas supporting speech production mediate audiovisual speech perception
    Jeremy I Skipper
    Department of Neurology, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Cereb Cortex 17:2387-99. 2007
  25. pmc Hyperacute directional hearing and phonotactic steering in the cricket (Gryllus bimaculatus deGeer)
    Stefan Schöneich
    Department of Zoology, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 5:e15141. 2010
    Auditory mate or prey localisation is central to the lifestyle of many animals and requires precise directional hearing. However, when the incident angle of sound approaches 0° azimuth, interaural time and intensity differences ..
  26. pmc A role for epigenetics in hearing: Establishment and maintenance of auditory specific gene expression patterns
    Matthew J Provenzano
    Department of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City, IA 52242 1181, United States
    Hear Res 233:1-13. 2007
    ..Despite its centricity to molecular biology, little work has been conducted examining how epigenetics affects hearing. In this review, we discuss both the basic tenets of epigenetics and highlight the most recent advances in this ..
  27. pmc Sound localization skills in children who use bilateral cochlear implants and in children with normal acoustic hearing
    Tina M Grieco-Calub
    Waisman Center, University of Wisconsin Madison, Madison, Wisconsin, USA
    Ear Hear 31:645-56. 2010
    ..e., localization accuracy) by comparing performance under bilateral and unilateral listening conditions; and to determine whether sound source localization continues to improve with longer durations of bilateral experience...
  28. pmc An ENU-induced mutation of Cdh23 causes congenital hearing loss, but no vestibular dysfunction, in mice
    Shehnaaz S M Manji
    Genetic Hearing Research Laboratory, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria, Australia
    Am J Pathol 179:903-14. 2011
    ..in the human cadherin 23 (CDH23) gene cause deafness, neurosensory, autosomal recessive 12 (DFNB12) nonsyndromic hearing loss or Usher syndrome, type 1D (characterized by hearing impairment, vestibular dysfunction, and visual ..
  29. ncbi Hearing screening in a neonatal intensive care unit
    Gisele M L Lima
    Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas, SP, Brazil
    J Pediatr (Rio J) 82:110-4. 2006
    Investigate the prevalence of hearing impairment in newborns hospitalized at the Intensive and Intermediate Care Unit at the Women's Comprehensive Health Center Neonatology Service (UNICAMP) and associated risk factors.
  30. doi Grhl2 deficiency impairs otic development and hearing ability in a zebrafish model of the progressive dominant hearing loss DFNA28
    Yanchao Han
    Developmental Genetics Laboratory of Tsinghua University, School of Life Sciences, Tsinghua University, Beijing 100084, China
    Hum Mol Genet 20:3213-26. 2011
    Congenital and progressive hearing impairment is a common distressing disease...
  31. pmc Distinct roles of TRP channels in auditory transduction and amplification in Drosophila
    Brendan P Lehnert
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 77:115-28. 2013
    ..Thus, transduction and active amplification are genetically separable processes in Drosophila hearing.
  32. pmc Physical basis of two-tone interference in hearing
    F Jülicher
    Cavendish Laboratory, Madingley Road, Cambridge CB3 0HE, United Kingdom
    Proc Natl Acad Sci U S A 98:9080-5. 2001
    ..Our analysis provides a general framework for examining the relation between the physical nature of the peripheral detection apparatus and psychophysical phenomena such as the sensation of dissonance and auditory illusions...
  33. pmc Sharpened cochlear tuning in a mouse with a genetically modified tectorial membrane
    Ian J Russell
    School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UK
    Nat Neurosci 10:215-23. 2007
    ..Although these mice have a low-frequency hearing loss, basilar-membrane and neural tuning are both significantly enhanced in the high-frequency regions of the ..
  34. doi A new electrode for residual hearing preservation in cochlear implantation: first clinical results
    Wolfgang Gstoettner
    Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria
    Acta Otolaryngol 129:372-9. 2009
    A so far unattained high rate (100%) of residual hearing preservation in cochlear implantation for electric-acoustic stimulation could be achieved using sophisticated surgical techniques in combination with the MedEl Flex EAS electrode.
  35. pmc Knockout of the ASIC2 channel in mice does not impair cutaneous mechanosensation, visceral mechanonociception and hearing
    Carolina Roza
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UMR 6097, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    J Physiol 558:659-69. 2004
    Mechanosensitive cation channels are thought to be crucial for different aspects of mechanoperception, such as hearing and touch sensation. In the nematode C...
  36. doi The corpus callosum in dichotic listening studies of hemispheric asymmetry: a review of clinical and experimental evidence
    Rene Westerhausen
    Department of Biological and Medical Psychology, Cognitive Neuroscience Group, University of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
    Neurosci Biobehav Rev 32:1044-54. 2008
    ..The review has also revealed how inter-individual variability in callosal fiber structure affects both bottom-up and top-down performance on the dichotic listening task...
  37. doi Relations between frequency selectivity, temporal fine-structure processing, and speech reception in impaired hearing
    Olaf Strelcyk
    Centre for Applied Hearing Research, Department of Electrical Engineering, Technical University of Denmark, Building 352, Orsteds Plads, 2800 Kgs Lyngby, Denmark
    J Acoust Soc Am 125:3328-45. 2009
    Frequency selectivity, temporal fine-structure (TFS) processing, and speech reception were assessed for six normal-hearing (NH) listeners, ten sensorineurally hearing-impaired (HI) listeners with similar high-frequency losses, and two ..
  38. doi Rethinking sound detection by fishes
    Arthur N Popper
    Department of Biology and Center for Comparative and Evolutionary Biology of Hearing, University of Maryland, College Park, MD 20742, USA
    Hear Res 273:25-36. 2011
    In this paper we reconsider the designation of fishes as being either "hearing specialists" or "hearing generalists," and recommend dropping the terms...
  39. pmc Normal hearing is not enough to guarantee robust encoding of suprathreshold features important in everyday communication
    Dorea Ruggles
    Department of Biomedical Engineering, Boston University Hearing Research Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 108:15516-21. 2011
    Normal hearing" is typically defined by threshold audibility, even though everyday communication relies on extracting key features of easily audible sound, not on sound detection...
  40. ncbi Lefties get it "right" when hearing tool sounds
    James W Lewis
    Department of Physiology and Phamacology, West Virginia University, WV 26506 9229, USA
    J Cogn Neurosci 18:1314-30. 2006
    ..In right-handers, we previously reported that hearing hand-manipulated tool sounds preferentially activates a left hemisphere network of motor-related brain regions ..
  41. pmc Mouse model of enlarged vestibular aqueducts defines temporal requirement of Slc26a4 expression for hearing acquisition
    Byung Yoon Choi
    Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, NIH, Rockville, Maryland, USA
    J Clin Invest 121:4516-25. 2011
    Mutations in human SLC26A4 are a common cause of hearing loss associated with enlarged vestibular aqueducts (EVA)...
  42. pmc Relationship between swim bladder morphology and hearing abilities--a case study on Asian and African cichlids
    Tanja Schulz-Mirbach
    Department of Behavioral Biology, University of Vienna, Vienna, Austria
    PLoS ONE 7:e42292. 2012
    ..A few comparative studies have shown that these morphological specializations may enhance hearing abilities...
  43. ncbi The case for early identification of hearing loss in children. Auditory system development, experimental auditory deprivation, and development of speech perception and hearing
    Y S Sininger
    Children s Auditory Research and Evaluation Center, University of California Davis Medical Center, USA
    Pediatr Clin North Am 46:1-14. 1999
    ..Although it is not visible to observers, infants with hearing are learning to process speech and understand language and are quite linguistically sophisticated by 1 year of ..
  44. doi Prestin's role in cochlear frequency tuning and transmission of mechanical responses to neural excitation
    Marcia M Mellado Lagarde
    School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, United Kingdom
    Curr Biol 18:200-2. 2008
    ..Prestin is crucial for defining sharp and sensitive cochlear frequency tuning by reducing the sensitivity of the low-frequency tail of the tuning curve, although this necessitates a cochlear amplifier to determine the narrowly tuned tip...
  45. pmc The role of temporal fine structure processing in pitch perception, masking, and speech perception for normal-hearing and hearing-impaired people
    Brian C J Moore
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    J Assoc Res Otolaryngol 9:399-406. 2008
    ..Evidence is reviewed suggesting that cochlear hearing loss reduces the ability to use TFS cues...
  46. doi Otoacoustic emissions in a hearing conservation program: general applicability in longitudinal monitoring and the relation to changes in pure-tone thresholds
    Hiske W Helleman
    Clinical and Experimental Audiology, ENT Department, Academic Medical Centre, Amsterdam, The Netherlands
    Int J Audiol 49:410-9. 2010
    The hearing status of workers (N = 233) in a printing office was assessed twice within seventeen months by pure-tone audiometry and otoacoustic emissions (OAEs)...
  47. ncbi Audition in sciaenid fishes with different swim bladder-inner ear configurations
    John U Ramcharitar
    Department of Biology and Neuroscience and Cognitive Science Program, University of Maryland, College Park, Maryland 20742, USA
    J Acoust Soc Am 119:439-43. 2006
    We investigated how morphological differences in the auditory periphery of teleost fishes may relate to hearing capabilities...
  48. ncbi Hearing syllables by seeing visual stimuli
    Lutz Jancke
    University of Zurich, Institute of Psychology, Division of Neuropsychology, Treichlerstr 10, Switzerland
    Eur J Neurosci 19:2603-8. 2004
    ..To overcome the detrimental effects of scanner noise, one group of subjects was trained to vividly imagine hearing a syllable while a flashlight was presented. A control group did not receive this training...
  49. ncbi Reading, hearing, and the planum temporale
    Bradley R Buchsbaum
    Department of Health and Human Services, Unit on Integrative Neuroimaging, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1365, USA
    Neuroimage 24:444-54. 2005
    ..Moreover, increasing the smoothing window to 10 mm obliterates activation in the PT, suggesting that failure to find PT activation in past studies may relate to this factor...
  50. ncbi Two interdependent TRPV channel subunits, inactive and Nanchung, mediate hearing in Drosophila
    Zhefeng Gong
    Biology Department, University of Virginia, Charlottesville, Virginia 22904, USA
    J Neurosci 24:9059-66. 2004
    b>Hearing in Drosophila depends on the transduction of antennal vibration into receptor potentials by ciliated sensory neurons in Johnston's organ, the antennal chordotonal organ...
  51. pmc Maturation of glycinergic inhibition in the gerbil medial superior olive after hearing onset
    Anna K Magnusson
    Division of Neurobiology, Department Biologie II, Ludwig Maximilians University, Martinsried, Germany
    J Physiol 568:497-512. 2005
    ..was shown that the glycinergic input to the MSO undergoes an experience-dependent structural reorganization after hearing onset...
  52. doi Drosophila auditory organ genes and genetic hearing defects
    Pingkalai R Senthilan
    Department of Cellular Neurobiology, University of Gottingen, Julia Lermontowa Weg 3, 37077 Gottingen, Germany
    Cell 150:1042-54. 2012
    ..Only four of these genes had previously been associated with fly hearing, yet one in five of the genes that we identified has a human cognate that is implicated in hearing disorders...
  53. pmc Developmental regulation of spontaneous activity in the Mammalian cochlea
    Nicolas X Tritsch
    The Solomon H Snyder Department of Neuroscience and Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Neurosci 30:1539-50. 2010
    Neurons in the developing auditory system fire bursts of action potentials before the onset of hearing. This spontaneous activity promotes the survival and maturation of auditory neurons and the refinement of synaptic connections in ..
  54. pmc Tuning of the outer hair cell motor by membrane cholesterol
    Lavanya Rajagopalan
    Bobby R Alford Department of Otolaryngology Head and Neck Surgery, Huffington Center on Aging and Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 282:36659-70. 2007
    ..We observed that alterations of cochlear cholesterol modulate hearing in mice...
  55. doi Area Spt in the human planum temporale supports sensory-motor integration for speech processing
    Gregory Hickok
    Center for Cognitive Neuroscience, Department of Cognitive Sciences, University of California, Irvine, CA 92697, USA
    J Neurophysiol 101:2725-32. 2009
    ..This result suggests that just as the PPC supports sensorimotor integration for eye and limb movements, area Spt forms part of a sensory-motor integration circuit for the vocal tract...
  56. pmc Functional groups in the avian auditory system
    Sarah M N Woolley
    Department of Psychology, Columbia University, New York, New York 10027, USA
    J Neurosci 29:2780-93. 2009
    ..Comparing STRFs in midbrain and forebrain neurons suggested that both inheritance and emergence of tuning properties occur as information ascends the auditory processing stream...
  57. pmc Phase-sensitive optical coherence tomography imaging of the tissue motion within the organ of Corti at a subnanometer scale: a preliminary study
    Ruikang K Wang
    Oregon Health and Science University, Department of Biomedical Engineering, CH13B, 3303 Southwest Bond Avenue, Portland, Oregon 97239, USA
    J Biomed Opt 15:056005. 2010
    b>Hearing loss can mean severe impairment to the quality of life. However, the biomechanical mechanisms of how the hearing organ, i.e...
  58. pmc Musical experience and the aging auditory system: implications for cognitive abilities and hearing speech in noise
    Alexandra Parbery-Clark
    Auditory Neuroscience Laboratory, Northwestern University, Evanston, Illinois, United States of America
    PLoS ONE 6:e18082. 2011
    ..Although aging is generally accompanied by hearing loss, this perceptual decline cannot fully account for the difficulties experienced by older adults for hearing ..
  59. pmc Harmonin mutations cause mechanotransduction defects in cochlear hair cells
    Nicolas Grillet
    Department of Cell Biology, Institute for Childhood and Neglected Disease, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuron 62:375-87. 2009
    ..interactions with CDH23 and F-actin control harmonin localization in stereocilia and are necessary for normal hearing. In mice expressing a mutant harmonin protein that prevents UTLD formation, the sensitivity of hair bundles to ..
  60. pmc Development of form and function in the mammalian cochlea
    Michael C Kelly
    Department of Cell Biology, Emory University, 615 Michael Street, Atlanta, GA 30322, USA
    Curr Opin Neurobiol 19:395-401. 2009
  61. pmc Tricellulin is a tight-junction protein necessary for hearing
    Saima Riazuddin
    Section on Human Genetics, Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA
    Am J Hum Genet 79:1040-51. 2006
    ..spaces of the organ of Corti; the separation from one another by epithelial barriers is required for normal hearing. TRIC encodes tricellulin, a recently discovered tight-junction (TJ) protein that contributes to the structure ..
  62. doi Effects of hearing aid fitting on the perceptual characteristics of tinnitus
    G Moffat
    Laboratoire de Neurobiologie Integrative et Adaptative, UMR CNRS 6149, 3 Place Victor Hugo, Marseille, F 13331 Cedex 03, France
    Hear Res 254:82-91. 2009
    Restoration of auditory input through the use of hearing aids has been proposed as a potentially important means of altering tinnitus among those tinnitus sufferers who experience significant sensorineural hearing loss...
  63. doi Targeted three-dimensional immunohistochemistry reveals localization of presynaptic proteins Bassoon and Piccolo in the rat calyx of Held before and after the onset of hearing
    Anna Dondzillo
    Department of Anatomy and Cell Biology, University of Heidelberg, 69120 Heidelberg, Germany
    J Comp Neurol 518:1008-29. 2010
    ..3D localization of Bassoon and Piccolo in the rat calyx of Held between postnatal days 9 and 21, the period of hearing onset characterized by pronounced structural and functional changes...
  64. ncbi Tinnitus in hamsters following exposure to intense sound
    Henry E Heffner
    Department of Psychology, University of Toledo, Toledo, OH 43606, USA
    Hear Res 170:83-95. 2002
    ..5 and 1 h did not. The degree of hearing loss produced by the tone exposure was assessed using behavioral and auditory brainstem response (ABR) procedures...
  65. pmc The tectorial membrane: one slice of a complex cochlear sandwich
    Guy P Richardson
    School of Life Sciences, University of Sussex, Falmer, Brighton, UK
    Curr Opin Otolaryngol Head Neck Surg 16:458-64. 2008
    ..is both timely and relevant, as recent findings have shown the tectorial membrane plays a more dynamic role in hearing than hitherto suspected, and that many forms of deafness can result from mutations in tectorial membrane proteins.
  66. pmc Visual advantage in deaf adults linked to retinal changes
    Charlotte Codina
    Academic Unit of Ophthalmology and Orthoptics, University of Sheffield, Sheffield, United Kingdom
    PLoS ONE 6:e20417. 2011
    ..We investigated neural changes at the retina and optic nerve head in profoundly deaf (N = 14) and hearing (N = 15) adults using Optical Coherence Tomography (OCT), an in-vivo light interference method of quantifying ..
  67. ncbi Development of form and function in peripheral auditory structures of the zebrafish (Danio rerio)
    Dennis M Higgs
    Department of Biology, University of Maryland, College Park, Maryland 20742, USA
    J Acoust Soc Am 113:1145-54. 2003
    ..of frequency range coincided with the development of Weberian ossicles in zebrafish, suggesting that changes in hearing ability in this species are driven more by development of auxiliary specializations than by the ear itself...
  68. ncbi Hearing speech sounds: top-down influences on the interface between audition and speech perception
    Matthew H Davis
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Hear Res 229:132-47. 2007
    ..We propose that top-down interactive mechanisms within auditory networks play an important role in explaining the perception of spoken language...
  69. doi Role of corticofugal feedback in hearing
    Nobuo Suga
    Department of Biology, Washington University, One Brookings Drive, St Louis, MO 63130, USA
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 194:169-83. 2008
    ..The corticofugal system has multiple functions. One of the most important functions is the improvement and adjustment (reorganization) of subcortical auditory signal processing for cortical signal processing...
  70. ncbi A comparative study of hearing ability in fishes: the auditory brainstem response approach
    T N Kenyon
    T H Morgan School of Biological Sciences, University of Kentucky, Lexington 40506 0225, USA
    J Comp Physiol A 182:307-18. 1998
    ..ABR) techniques, an electrophysiological far-field recording method widely used in clinical evaluation of human hearing, were adapted for fishes to overcome the major limitations of traditional behavioral and electrophysiological ..
  71. ncbi Seasonal plasticity of peripheral auditory frequency sensitivity
    Joseph A Sisneros
    Department of Neurobiology and Behavior, Cornell University, Ithaca, New York 14853, USA
    J Neurosci 23:1049-58. 2003
  72. ncbi Frequency organization of the 40-Hz auditory steady-state response in normal hearing and in tinnitus
    Christian Wienbruch
    Department of Psychology, University of Konstanz, Box D25, 78457 Konstanz, Germany
    Neuroimage 33:180-94. 2006
    ..representations in the region of primary auditory cortex (PAC) between subjects with chronic tinnitus and hearing impairment and normal hearing controls...
  73. ncbi Is there a role of visual cortex in spatial hearing?
    Ulrike Zimmer
    Section Neuropsychology, Department of Cognitive Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Eur J Neurosci 20:3148-56. 2004
    ..This result suggests a relation of neural processing in the visual cortex and the transformation of auditory spatial coordinates responsible for maintaining the perceptual alignment of audition and vision with changes in gaze direction...
  74. ncbi Expression of a potassium current in inner hair cells during development of hearing in mice
    C J Kros
    Department of Physiology, School of Medical Sciences, University of Bristol, UK
    Nature 394:281-4. 1998
    ..This change in potassium channel expression turns the inner hair cell from a regenerative, spiking pacemaker into a high-frequency signal transducer...
  75. ncbi Hearing molecules: contributions from genetic deafness
    M D Eisen
    Department of Otolaryngology Head and Neck Surgery, Center for Hearing and Balance, Baltimore, Maryland 21205, USA
    Cell Mol Life Sci 64:566-80. 2007
    ..the identification of these hereditary deafness genes and the proteins they encode, molecular elements of basic hearing mechanisms emerge...
  76. pmc Quantitative imaging of cochlear soft tissues in wild-type and hearing-impaired transgenic mice by spectral domain optical coherence tomography
    Simon S Gao
    Department of Otolaryngology Head and Neck Surgery, Stanford University, 801 Welch Road, Stanford, CA 94305, USA
    Opt Express 19:15415-28. 2011
    Human hearing loss often occurs as a result of damage or malformations to the functional soft tissues within the cochlea, but these changes are not appreciable with current medical imaging modalities...
  77. ncbi A deafness mutation isolates a second role for the tectorial membrane in hearing
    P Kevin Legan
    School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UK
    Nat Neurosci 8:1035-42. 2005
    ..In humans, the Y1870C missense mutation in TECTA causes a 50- to 80-dB hearing loss...
  78. pmc Acoustic to electric pitch comparisons in cochlear implant subjects with residual hearing
    Colette Boex
    Centre romand d implants cochléaires, Department of Otolaryngology Head and Neck Surgery, Cantonal University Hospital of Geneva, Geneve, Switzerland
    J Assoc Res Otolaryngol 7:110-24. 2006
    ..function resulting from electric stimulation of electrodes in cochlear implant subjects with significant residual hearing in their nonimplanted ear...
  79. ncbi Eocene evolution of whale hearing
    Sirpa Nummela
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44272, USA
    Nature 430:776-8. 2004
    ..transmission mechanisms change early on in whale evolution and pass through a stage (in pakicetids) in which hearing in both air and water is unsophisticated...
  80. doi Spatial speech perception benefits in young children with normal hearing and cochlear implants
    Lieselot Van Deun
    ExpORL, Department of Neurosciences, K U Leuven, Leuven, Belgium
    Ear Hear 31:702-13. 2010
    ..Moreover, little data are available on the binaural hearing abilities of normal-hearing children...
  81. pmc Why middle-aged listeners have trouble hearing in everyday settings
    Dorea Ruggles
    Department of Biomedical Engineering, Center for Computational Neuroscience and Neural Technology, Boston University, Boston, MA 02215, USA
    Curr Biol 22:1417-22. 2012
    ..Moreover, young adult listeners with "normal" hearing vary in their ability to selectively attend to speech amid similar streams of speech...
  82. pmc Loss of mammal-specific tectorial membrane component carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies
    Robert Kammerer
    Instute of Immunology, Friedrich Loeffler Institut, 17493 Greifswald Insel Riems, Germany
    J Biol Chem 287:21584-98. 2012
    ..In young Ceacam16(-/-) mice the hearing threshold for frequencies below 10 kHz and above 22 kHz was raised. This hearing impairment progressed with age...
  83. ncbi Fully implantable hearing aids in patients with congenital auricular atresia
    Ralf Siegert
    Prosper Hospital, Academic Teaching Hospital of Ruhr University Bochum, Recklinghausen, Germany
    Laryngoscope 117:336-40. 2007
    Patients with congenital auricular atresia suffer from a conductive hearing loss (HL) with an air-bone gap of 50 to 60 dB...
  84. pmc Social drive and the evolution of primate hearing
    Marissa A Ramsier
    Department of Anthropology, University of California, 1156 High Street, Santa Cruz, CA 95064, USA
    Philos Trans R Soc Lond B Biol Sci 367:1860-8. 2012
    ..Yet, the comparative biology of primate hearing is limited to select species, and little attention has been paid to the effects of social and vocal complexity on ..
  85. doi The contribution of the lateral line to 'hearing' in fish
    D M Higgs
    Department of Biological Sciences, University of Windsor, Windsor, ON, Canada N9B 3P4
    J Exp Biol 216:1484-90. 2013
    ..A now common way to test 'hearing' in fish involves auditory evoked potentials (AEPs), with recordings made from electrodes implanted near the ..
  86. ncbi Sentence intelligibility in noise for listeners with normal hearing and hearing impairment: influence of measurement procedure and masking parameters
    Kirsten Carola Wagener
    Carl von Ossietzky Universitat, Oldenburg, Medizinische Physik, Fakultät V Institut für Physik, Oldenburg, Germany
    Int J Audiol 44:144-56. 2005
    ..presentation mode on speech reception thresholds (SRTs), and intelligibility function slopes in noise for normal-hearing and hearing-impaired subjects...
  87. pmc Cochlear amplification, outer hair cells and prestin
    Peter Dallos
    Northwestern University, Departments of Neurobiology and Physiology and Communication Sciences and Disorders, The Hugh Knowles Center, 2240 Campus Drive, Evanston, IL 60208, USA
    Curr Opin Neurobiol 18:370-6. 2008
    ..One of the central outstanding problems in mammalian cochlear neurobiology is the relation between the two amplification processes...
  88. doi Transducer-based force generation explains active process in Drosophila hearing
    Björn Nadrowski
    Sensory Systems Lab, Institute of Zoology, University of Cologne, Weyertal 119, 50923 Cologne, Germany
    Curr Biol 18:1365-72. 2008
    ..This molecular arrangement explains the active properties of the sensory hair bundles of inner-ear hair cells, but whether it suffices to explain the active macroscopic performance of auditory systems is unclear...
  89. ncbi Stop-consonant recognition for normal-hearing listeners and listeners with high-frequency hearing loss. I: The contribution of selected frequency regions
    J R Dubno
    UCLA School of Medicine, Division of Head and Neck Surgery 90024
    J Acoust Soc Am 85:347-54. 1989
    ..this study is to specify the contribution of certain frequency regions to consonant place perception for normal-hearing listeners and listeners with high-frequency hearing loss, and to characterize the differences in stop-consonant ..
  90. ncbi Variation in the hearing sensitivity of a dolphin population determined through the use of evoked potential audiometry
    Dorian S Houser
    BIOMIMETICA, 7951 Shantung Drive, Santee, California 92071, USA
    J Acoust Soc Am 120:4090-9. 2006
    A portable electrophysiological data collection system was used to assess hearing in a captive population of bottlenose dolphins by recording auditory evoked potentials (AEPs)...
  91. pmc The influence of hearing aids on the speech and language development of children with hearing loss
    J Bruce Tomblin
    Department of Communication Sciences and Disorders, The University of Iowa, Iowa City
    JAMA Otolaryngol Head Neck Surg 140:403-9. 2014
    IMPORTANCE Hearing loss (HL) in children can be deleterious to their speech and language development...
  92. doi Hearing silences: human auditory processing relies on preactivation of sound-specific brain activity patterns
    Iria SanMiguel
    Institute for Psychology, University of Leipzig, 04103 Leipzig, Germany
    J Neurosci 33:8633-9. 2013
    ..Electrophysiological brain signals showed that when a clear prediction can be formulated, the brain activates a template of its response to the predicted stimulus before it arrives to our senses...
  93. doi Hearing acuity as a predictor of walking difficulties in older women
    Anne Viljanen
    Department of Health Sciences, Finnish Centre for Interdisciplinary Gerontology, University of Jyvaskyla, Jyvaskyla, Finland
    J Am Geriatr Soc 57:2282-6. 2009
    To examine whether hearing acuity correlates with walking ability and whether impaired hearing at baseline predicts new self-reported walking difficulties after 3 years.
  94. ncbi Assessment of hearing and hearing disorders in rock/jazz musicians
    Kim Kähärit
    National Institute for Working Life West, Department of Audiology, Goteborg University, Goteborg, Sweden
    Int J Audiol 42:279-88. 2003
    The aim of this study was to assess hearing and hearing disorders among rock/jazz musicians. One hundred and thirty-nine (43 women and 96 men) musicians participated...
  95. pmc Multidimensional scaling between acoustic and electric stimuli in cochlear implant users with contralateral hearing
    Katrien Vermeire
    Antwerp University Hospital, Department of Otorhinolaryngology and Head and Neck Surgery, University of Antwerp, Wilrijkstraat 10, 2650 Edegem, Belgium C Doppler Laboratory for Active Implantable Systems, Institute of Ion Physics and Applied Physics, University of Innsbruck, Innsbruck, Austria Thomas More University College, Gezondheid and Welzijn, Logopedie en Audiologie, Jozef De Bomstraat 11, 2018 Antwerpen, Belgium Electronic address
    Hear Res 306:29-36. 2013
    ..perceptual relationship between acoustic and electric stimuli presented to CI users with functional contralateral hearing. Fourteen subjects with unilateral profound deafness implanted with a MED-EL CI scaled the perceptual differences ..
  96. doi Hearing function and thresholds: a genome-wide association study in European isolated populations identifies new loci and pathways
    Giorgia Girotto
    Medical Genetics, Department of Reproductive Sciences and Development, IRCCS Burlo Garofolo, University of Trieste, Italy
    J Med Genet 48:369-74. 2011
    b>Hearing is a complex trait, but until now only a few genes are known to contribute to variability of this process...
  97. pmc TRPA channels distinguish gravity sensing from hearing in Johnston's organ
    Yishan Sun
    Neuroscience Graduate Program, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 106:13606-11. 2009
    ..mutating specific TRP genes produced distinct phenotypes, disrupting negative geotaxis (painless and pyrexia), hearing (nompC), or both (nanchung and inactive)...
  98. doi Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells
    Tina Pangrsic
    InnerEarLab, Department of Otolaryngology and Center for Molecular Physiology of the Brain, University Medical Center Gottingen, Gottingen, Germany
    Nat Neurosci 13:869-76. 2010
    ..that an aspartate to glycine substitution in the C(2)F domain of the synaptic vesicle protein otoferlin impaired hearing by reducing vesicle replenishment in the pachanga mouse model of human deafness DFNB9...
  99. pmc Word recognition within a linguistic context: effects of age, hearing acuity, verbal ability, and cognitive function
    Jonathan Benichov
    Department of Psychology and Volen National Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    Ear Hear 33:250-6. 2012
    ..The objective of this study was to examine the effects of adult age, hearing acuity, verbal ability, and cognitive function on the use of linguistic context in spoken word recognition.
  100. doi Matching sender and receiver: poikilothermy and frequency tuning in a tree cricket
    Natasha Mhatre
    School of Biological Sciences, Woodland Road, University of Bristol, Bristol BS8 1UG, UK
    J Exp Biol 214:2569-78. 2011
  101. doi Hearing preservation via a cochleostomy approach and deep insertion of a standard length cochlear implant electrode
    Iain Alexander Bruce
    Manchester Auditory Implant Centre, Manchester, UK
    Otol Neurotol 32:1444-7. 2011
    The suggestion that the depth of insertion of the electrode into the cochlea is critical to hearing preservation has led to the development of a generation of short electrodes designed to minimize intracochlear trauma and avoid contact ..

Research Grants83

  1. Can L-carnitine prevent drug-induced hearing loss?
    Gilda Kalinec; Fiscal Year: 2004
    b>Hearing loss is a prevalent and chronic health condition that affects between 22 and 28 million Americans...
  2. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
  3. Targeting Inflammation for the Amelioration of Cisplatin-Hearing Loss
    Vickram Ramkumar; Fiscal Year: 2011
    ..Knockdown of these proteins reduced damage to OHCs and reduced hearing loss induced by cisplatin...
  4. Steroid Responsive Mechanisms in the Ear
    DENNIS ROYAL TRUNE; Fiscal Year: 2012
    ..Glucocorticoids (prednisone, methlyprednisolone, dexamethasone) have been employed for decades for control of hearing loss. However, little is known of the cellular and molecular processes of the ear that are under their control...
  5. Genetic Studies of Optic Atrophy
    Taosheng Huang; Fiscal Year: 2012
    ..Our preliminary results also show that some OPA1 mutations cause loss of vision, hearing, and other organ abnormalities...
  6. Estrogen Modulation of Auditory Processing
    Raphael Pinaud; Fiscal Year: 2012
    ..b>Hearing disorders and lower auditory processing efficiency also occur in women with Turner's syndrome, who are ..
  7. Human middle-ear imaging, physiology, and biomechanics
    CHARLES RICHARD STEELE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The middle ear plays a vital role in the sense and sensitivity of hearing, yet there is currently a lack of knowledge about the mechanisms of high-frequency middle-ear sound transmission in mammals...
  8. Transplatin: A Novel Agent to Mitigate Cisplatin Toxicity
    Vickram Ramkumar; Fiscal Year: 2013
    ..Loss of hearing at this developmental stage hampers speech, cognition and social development...
  9. Predicting Bilirubin-induced Auditory Toxicity in Infants with Severe Jaundice
    Sanjiv B Amin; Fiscal Year: 2010
    Severe jaundice causes chronic post-kernicteric encephalopathy, sensori-neural hearing loss (SNHL), and auditory neuropathy (AN) in infants...
  10. Anti-Bacterial Innate Responses Enhance Paramyxovirus Replication
    Griffith D Parks; Fiscal Year: 2010
    ..Sequelae of recurrent otitis media include hearing and speech impairment that significantly impact the quality of life of both children and their parents/caregivers...
    Douglas H Keefe; Fiscal Year: 2013
    ..Monitoring of Middle-Ear and Cochlear Function A wideband (WB) acoustic test battery has the potential to improve hearing screening and diagnosis of middle-ear and cochlear dysfunction across the age range...
  12. Retroviral Vector-mediated Liver Gene Therapy for MPS I
    Katherine P Ponder; Fiscal Year: 2013
    ..The severe form, known as Hurler syndrome, causes bone and joint abnormalities, pulmonary and cardiac disease, hearing and visual deficiencies, mental retardation, and death around age 5 if untreated...
    Moosa Mohammadi; Fiscal Year: 2013
    ..Perturbed FGF signaling leads to numerous human diseases, including skeletal, reproductive syndromes, hearing loss, renal phosphate wasting, neurodegenerative disorders, and cancer...
  14. Amelioration of cisplatin ototoxicity by transplatin
    Debashree Mukherjea; Fiscal Year: 2010
    ..Specific Aim 1 will determine the effectiveness of transplatin against cisplatin-induced hearing loss, using either systemic administration or by direct round window application of transplatin...
  15. Mechanisms of Cochlear Oxidative Stress Injury and Strategies to Protect Hearing
    Michael J Brenner; Fiscal Year: 2013
    ..in the treatment of life-threatening infections, but they are also associated with a risk of permanent, bilateral hearing loss, as well as balance disturbance, tinnitus, and nephrotoxicity...
  16. Evolution of the Immune Response to Cytomegalovirus Transmitted via Breast Milk
    Lynn Puddington; Fiscal Year: 2010
    ..HCMV) infection in utero (congenital) can result in growth retardation, microcephaly, sensorineural hearing loss, and even death. HCMV infection also occurs postnatally in newborns via viral transmission in breast milk...
    Dennis G Drescher; Fiscal Year: 2013
    ..in continued, detailed elucidation of structure and molecular function of peripheral neurotransmitter systems of hearing and balance, pointing the way to development of biochemical and genetic therapies for transmitter-related hearing ..
  18. Characterization of an essential mitochondrial rRNA methyltransferase
    Kip E Guja; Fiscal Year: 2013
    ..be related to the effect of aminoglycoside antibiotics on the mitochondrial ribosome and aminoglycoside-induced hearing loss...
  19. Understanding thyroid hormone regulation of neurogenesis in the cochlea
    Mirna Mustapha; Fiscal Year: 2013
    Abstract Hearing impairment is prevalent and has significant implications for quality of life. There are currently no available clinical cures for hereditary inner ear disease or reliable means of preventing age related hearing loss...
  20. Preclinical testing of a novel PDK1 inhibitor for treating vestibular schwannoma
    Abraham Jacob; Fiscal Year: 2013
    ..VS are intracranial tumors that cause sensorineural hearing loss, balance abnormalities, tinnitus, vertigo, facial weakness, hydrocephalus, seizures, blindness, and even ..
  21. Basic and Clinical Studies of Noise-Induced and Age-Related Hearing Loss
    Sharon G Kujawa; Fiscal Year: 2012
    ..prevention of slow-onset neurodegeneration in our noise- exposed mice has important ramifications for human hearing. It suggests that primary neuronal loss is a more common and important aspect of acquired sensorineural hearing ..
  22. Visualization of ototoxic mitochondrial dysfunction in mammalian hair cells
    Shelley A Batts; Fiscal Year: 2012
    b>Hearing impairment is often caused by the sudden or gradual death of the cochlear hair cells, which are vulnerable to damage from noise, age, infection and toxic drugs...
  23. Air Toxics, Neighborhood Environment and Risk of Oral Clefts
    Philip J Lupo; Fiscal Year: 2013
    ..Children with CL[unreadable]P suffer deficits in speech, hearing and cognition and have higher morbidity and mortality throughout life compared to their unaffected contemporaries...
  24. Familial and Birth Cohort Effects on the Aging Senses
    Karen J Cruickshanks; Fiscal Year: 2013
    ..by principal investigator): The purpose of this epidemiologic study is to determine the 5-year incidence of hearing, vision, and olfactory impairments, sensory co-morbidity and age-related macular degeneration in the Beaver Dam ..
  25. Basic Mechanisms in Hearing Loss of Cochlear Origin
    Allen F Ryan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Objectives: Sensorineural hearing loss (SNHL) is strongly associated with many aspects of military service including blast injury...
  26. Endothelial-reactive antibodies: a diagnostic test for Susac's syndrome
    WILLIAM JAMES WALDMAN; Fiscal Year: 2011
    ..disorder characterized by a clinical triad of encephalopathy, branch retinal artery occlusion (BRAO), and hearing loss...
  27. Functional characterization of the Bronx waltzer deafness gene
    Botond Banfi; Fiscal Year: 2013
    ..provided by applicant): The characterization of mutant mice with deafness has led to important discoveries in hearing research, yet the deafness-causing gene defects in a few publicly available mouse strains remain unidentified...
    Keiko Hirose; Fiscal Year: 2013
    ..Research in human subjects demonstrates that hearing loss is successfully treated with corticosteroids in some patients, presumably due to their anti-inflammatory and ..
  29. The Role of FKBP10 in Recessive Osteogenesis Imperfecta
    Caressa Lietman; Fiscal Year: 2013
    ..low bone mass, whereas patients may also display blue sclera, dentinogenesis imperfecta, joint and skin laxity, hearing impairment and/or wormian bones on the skull [1]...
  30. Matrix Otopathology
    MICHAEL ANNE NMI GRATTON; Fiscal Year: 2011
    ..The relationship between abnormal basement membranes and hearing loss is explored by determining the consequences of basement membrane accumulation on peripheral auditory ..
  31. Effects of nerve demyelination on auditory synaptic functions
    Jun Hee Kim; Fiscal Year: 2012
    ..Interestingly, some of MS patients show hearing acuity loss with normal cochlear function, referred as auditory neuropathy...
    Robert Fettiplace; Fiscal Year: 2013
    ..aims are: (1) to record mechanotransducer currents in gerbil and rat hair cells before and after the onset of hearing, documenting the changes in kinetics and other properties with cochlear location;(2) to characterize single ..
  33. Structure-function analyses on novel processes of type II vestibular hair cells
    Jennifer S Stone; Fiscal Year: 2013
    ..Studies of damaged vestibular organs will help uncover the relationship between normal and regenerated hair cells with processes and the potential of regenerated hair cells to restore function in balance and hearing disorders.
  34. Cloning &Functional Studies of Deafness Mutations
    Kenneth R Johnson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The mouse is an excellent model for studying human hearing disorders because of the similarities in inner ear anatomy, function, and pathology...
  35. Genetics of Age-Related Hearing Loss
    Kenneth R Johnson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Presbycusis or age-related hearing loss (AHL) is the most common sensory deficit in aging human populations and a major factor in reducing the quality of life of the elderly...
  36. Core Center for BioBehavioral Sciences of Communication Disorders
    Mabel L Rice; Fiscal Year: 2013
    ..The topics focus on speech and language impairments, with a new investigator of hearing/balance impairments...
  37. Genomic approaches to inner ear hair cell regeneration
    Michael Lovett; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Damage to inner ear hair cells is a leading cause of irreversible human hearing loss and balance disorders, which affect >10% of the world's population...
  38. The Effect Of Deafness Associated Mutations on MyosinVIIA Function
    Eva Forgacs; Fiscal Year: 2010
    ..by deafness, vestibular dysfunction and blindness (retinitis pigmentosa), and two autosomal recessive hearing disorders, DFNA11 and DFNB2 in humans, and the shaker-1 phenotype in mice...
  39. Novel immunotherapeutics for the management of otitis media due to H. influenzae
    Steven D Goodman; Fiscal Year: 2013
    ..Our goals are thus fully in keeping with both Healthy People 2010 (28: Vision and Hearing, Section 28-12), and the NIDCD strategic plan FY 2009-2011, wherein a priority research area is Molecular and Non-..
  40. Novel biofilm polymicrobial infection-resistant implants for otologic application
    Paul Stoodley; Fiscal Year: 2010
    ..tube otorrhea (PTTO) is often refractory to treatment and inflicts significant morbidity in the form of hearing loss and long-term middle ear dysfunction...
  41. Inner Ear Impact of Chronic Middle Ear Inflammation
    DENNIS ROYAL TRUNE; Fiscal Year: 2013
    ..into the inflammatory mechanisms by which otitis media causes permanent cochlear changes, such as sensorineural hearing loss...
    Leonard P Rybak; Fiscal Year: 2012
    ..This enzyme generates superoxide radicals that can damage outer hair cells (OHCs), leading to hearing loss. ROS can activate cochlear genes that may be protective or harmful...
  43. For Hearing Component in the Hispanic Community Health Study (HCHS)
    Lisa Lavange; Fiscal Year: 2009
    ..of blood pressure, anthropometry, physical activity, spirometry, sleep studies, ECG, dental examination, hearing examination, and cognitive status measurement...
  44. Environment, Novel Aging Outcomes, and Genetics
    Sung Kyun Park; Fiscal Year: 2013
    ..and two novel outcomes that have been relatively little studied in environmental health, age-related cataract and hearing loss...
    DOMINIC E COSGROVE; Fiscal Year: 2012
    ..genes have been identified, and the encoded proteins interact with each other, but the functional connection with hearing and vision is still unknown...
    Donald M Caspary; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Age-related hearing loss is a complex disorder affecting 30% of the US population aged 65 to 74 years, and 50% of the population over 75 years of age and older...
  47. Novel vaccine to CMV based on a disc virus
    Alistair McGregor; Fiscal Year: 2010
    ..1% of live births in the US) can lead to serious symptomatic disease including mental retardation and hearing loss...
  48. Biology of the HMW1 and HMW2 Adhesins of H. Influenzae
    JOSEPH W ST. GEME; Fiscal Year: 2013
    ..of acute otitis media, fluid remains in the middle ear for weeks to months and is associated with significant hearing deficit, a sequela that in turn can impair language acquisition, speech development, and school performance...
  49. A cell-specific inducible model of hearing loss
    Albert S Edge; Fiscal Year: 2011
    ..specific cell types in the cochlea including hair cells and spiral ganglion neurons, two critical cell types for hearing loss. Such a model would expedite studies on cell function and development as well as inner ear regeneration...
  50. Brain changes in tinnitus
    Josef P Rauschecker; Fiscal Year: 2010
    ..external stimulus, is perceived by about 15% of the adult population, and about 75% of all patients with hearing loss. It can cause severe suffering, and to date, no reliable cure has been found...
  51. Identifying the Atoh1 targetome in hair cells with deep sequencing
    Andrew K Groves; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hearing and balance disorders are some of the most common disabilities in the United States, with 0...
  52. Myosin 15:Genetics, Pathology and Therapeutic Potential
    Sally A Camper; Fiscal Year: 2013
    ..Although there is no enhanced risk of age related hearing loss in double heterozygotes, these studies revealed unique functions of each myosin gene, and suggested the ..
  53. Transport ATPases: From Molecules to Maladies
    Rajini Rao; Fiscal Year: 2010
    ..them: cancer and drug resistance, heart disease, immune and infectious diseases, ulcers, diabetes, vision and hearing loss, neurodegeneration and mitochondrial diseases...
    Alexander A Spector; Fiscal Year: 2012
    ..and the outer hair cell uses its "electric motor" to enhance the sensitivity and frequency selectivity of hearing. The goal of our multidisciplinary team is to understand the biological and physical basis of the outer hair cell ..
    Lauren O Bakaletz; Fiscal Year: 2013
    ..physician's office and emergency room visits, undergo surgery requiring general anesthesia, and experience hearing loss...
  56. Auditory Neuroprotection by Small Molecule Agonists of the TrkB Receptor
    Keqiang Ye; Fiscal Year: 2013
    ..to the human cochlea to promote the survival of residual SG neurons in the cochlea of severe sensorineural hearing loss patients...
  57. Pilot Study: Self Management Groups for Veterans with Dual Sensory Loss
    MITCHEL BRANT TURBIN; Fiscal Year: 2011
    ..provided by applicant): Project Summary/Abstract The risk that a Veteran will experience concurrent visual and hearing impairments increases with age...
  58. Regeneration of stereocilia of cochlear hair cells
    David Z Z He; Fiscal Year: 2010
    The senses of hearing and balance depend upon hair cells, the sensory receptors of the inner ear. Hair cells transduce mechanical stimuli into electrical activity...
  59. Preventing hair cell loss by regulating prestin's function
    Jing Zheng; Fiscal Year: 2010
    ..OHCs are also the most vulnerable cells in the inner ear and are involved in a majority of sensorineural hearing loss...
  60. Mechanics of Inner Ear Hair Bundles
    ..the stereocilia move together in a mammalian hair cell, we can generate quantitative biophysical models for how hearing works in the kilohertz range...
  61. Light-Alarming Personal Noise Dosimeter System
    ALEXANDER MILOVANOV; Fiscal Year: 2013
    ..Occupational noise is a widespread risk factor, linking it strongly to critical health hazards, such as hearing loss, psychiatric disorders, increased blood pressure, and harmful biochemical, immune system, and birth-weight ..
  62. Novel Approaches for Prevention and Treatment of Noise Induced Hearing loss
    Debashree Mukherjea; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Noise induced hearing loss (NIHL) is a significant problem in the United States, affecting ~15 percent of individuals from all age groups...
  63. The Role of Eya4 in Hearing and Disease
    Jonathan G Seidman; Fiscal Year: 2010
    ..Mutations in the transcriptional co-activator EYA4 are responsible for autosomal dominant sensorineural hearing loss at the DFNA10 locus. Mice carrying mutant Eya4 alleles provide a model of human hearing loss...
  64. Evaluation of Approaches to Auditory Rehabilitation for Mild TBI
    Gabrielle Saunders; Fiscal Year: 2009
    ..for veterans who have normal/near-normal peripheral auditory function and significant complaints of difficulty hearing. Many are veterans of the OIF/OEF conflicts who have been exposed to blast - the most common wounding etiology in ..
  65. Targeting S1P receptors to prevent hearing loss
    Jerold Chun; Fiscal Year: 2010
    Targeting S1P receptors to prevent hearing loss Cochlear hair cells, the primary functional subunits required for the transduction of vibration into the auditory sensation, are subject to irreversible degeneration and consequent loss of ..
  66. Telephone screening test for hearing using three-digit sequences in noise.
    Charles Watson; Fiscal Year: 2009
    This project will develop a speech-recognition test in noise (SRTn) for use as a screening test for hearing disability, suitable for delivery over the telephone...
    Jianxin Bao; Fiscal Year: 2010
    ..DESCRIPTION (provided by applicant): Noise is the most common occupational and environmental hazard. Noise-induced hearing loss (NIHL) is the second most common form of sensorineural hearing deficit, after age-related hearing loss (..
  68. Determinants of Word Recognition Speed in Older Listeners
    Frederick J Gallun; Fiscal Year: 2011
    ..This problem is common even among older adults who do not have hearing loss...
  69. Ear Canal Optical Coherent Tomography System
    PAUL SHNITSER; Fiscal Year: 2010
    ..NIDCD) supports research and development of innovative technologies for improving the quality and utilization of hearing aid devices...
  70. Hearing Therapies for the Future
    Gabrielle Saunders; Fiscal Year: 2007
    ..The conference objective is to expand understanding and facilitate effective treatment of noise induced hearing loss (NIHL)...
  71. Genetic hearing screening for newborns
    Xi Lin; Fiscal Year: 2009
    Most states in the United States mandate a universal newborn hearing screening (UNHS) and average coverage rate is ~93% among newborns. However, most of those (>90%) who failed UNHS are false positives...
  72. Completely Digitizing the Custom-Fit Hearing Aid Shell Manufacturing Process
    STEVEN YI; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The average hearing aid costs $1,500, but prices can go up to $5,000 each. Yet Consumer Reports indicates that 40 percent of hearing aid users are unhappy with their devices...
  73. Wide-bandwidth open canal hearing aid for better multitalker speech understanding
    Sunil Puria; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Our goal is to design and build a new hearing aid system, which mitigates the most common complaints that hearing aid users have...
  74. The Ear-Brain System: Approaches to the Study and Treatment of Hearing Loss
    Gabrielle Saunders; Fiscal Year: 2009
    ..and researchers to discuss and learn about clinical issues associated with improvement of rehabilitation for hearing-impaired individuals...
  75. Multi-site study of speech perception training for hearing-aid users
    Charles S Watson; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Between 25 and 35% of the adults in the US who could benefit from hearing aids, as many as 25,000,000 persons, either refuse to consider those devices or reject them after a trial...
  76. High frequency auditory sensitivity in birds
    Bernard Lohr; Fiscal Year: 2004
    ..goal of this research is to advance the understanding of the limitations, diversity, and comparative aspects of hearing in birds...
  77. Ecological Momentary Assessment in Hearing Disorders
    James Henry; Fiscal Year: 2009
    The two most common auditory disorders among middle-aged Americans are hearing loss and tinnitus...
    Herenia Lawrence; Fiscal Year: 1999
    This study will evaluate a hypothetical association between tooth loss and age-related hearing loss in health male adults...
    Thomas Carey; Fiscal Year: 1999
    Sensorineural hearing loss (SNHL) of unexplained etiology is a common entity with an incidence rate of 1:10,000 for which there are few effective treatments...
  80. Development of the Mouse Cochlea Database
    PETER ALAN SANTI; Fiscal Year: 2010
    Among the five senses, hearing is fundamental for acquiring language, communication, and navigating through our environment...
  81. CTL2 ELISA: A Diagnostic Test for Autoimmune Hearing Loss
    Vijay Kumar; Fiscal Year: 2007
    unreadable] DESCRIPTION (Provided by applicant): Autoimmune hearing loss (AHL) is a subset of sensorineural hearing loss (SNHL) in which there is a sudden onset, or rapidly progressing and/or fluctuating hearing loss that often ..
    DAVID YAGER; Fiscal Year: 2004
    ..changes occur in the sensory periphery and the CNS during the evolutionary transition between earless and eared (hearing) animals...
  83. Individualized Objective Techniques for Early Detection of Ototoxicity
    MARILYN FARNSWORTH contact DILLE; Fiscal Year: 2011
    ..Unfortunately, cisplatin can produce cochlear damage resulting in irreversible hearing loss if treatment continues...