sensation

Summary

Summary: Transduction of physical or chemical changes in the external or internal environment into nerve impulses by specialized receptors, transmission of these impulses by afferent neurons to the effectors, either directly or through the CNS.

Top Publications

  1. ncbi From sensation to cognition
    M M Mesulam
    Department of Neurology, Northwestern University Medical School, Chicago 60611, USA
    Brain 121:1013-52. 1998
  2. pmc Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats
    Elena O Gracheva
    Department of Physiology, University of California, San Francisco, California 94158 2517, USA
    Nature 476:88-91. 2011
  3. ncbi Sit-to-stand performance depends on sensation, speed, balance, and psychological status in addition to strength in older people
    Stephen R Lord
    Prince of Wales Medical Research Institute, New South Wales, Australia
    J Gerontol A Biol Sci Med Sci 57:M539-43. 2002
  4. ncbi Time-varied characteristics of acupuncture effects in fMRI studies
    Lijun Bai
    Life Science Research Center, School of Electronic Engineering, Xidian University, Shaanxi, China
    Hum Brain Mapp 30:3445-60. 2009
  5. ncbi Is neocortex essentially multisensory?
    Asif A Ghazanfar
    Program in Neuroscience, Department of Psychology, Green Hall, Princeton University, Princeton, New Jersey, 08540, USA
    Trends Cogn Sci 10:278-85. 2006
  6. ncbi Neural basis of sensation in intact and injured corneas
    Carlos Belmonte
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez CSIC, Apdo correos 18, 03550 San Juan de Alicante, Spain
    Exp Eye Res 78:513-25. 2004
  7. pmc A vestibular sensation: probabilistic approaches to spatial perception
    Dora E Angelaki
    Department of Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 64:448-61. 2009
  8. pmc Acupuncture sensation during ultrasound guided acupuncture needling
    Jongbae J Park
    Department of Physical Medicine and Rehabilitation, UNC Chapel Hill, School of Medicine, 1st Floor, North Wing, UNC Hospitals, Campus Box 7200, Chapel Hill, NC 27599, USA
    Acupunct Med 29:257-65. 2011
  9. pmc Perceived harmfulness predicts nonmedical use of prescription drugs among college students: interactions with sensation-seeking
    Amelia M Arria
    Center for Substance Abuse Research, University of Maryland, 4321 Hartwick Rd, Suite 501, College Park, MD 20740, USA
    Prev Sci 9:191-201. 2008
  10. ncbi Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation
    Jun Chen
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL, USA
    Pain 152:1165-72. 2011

Detail Information

Publications293 found, 100 shown here

  1. ncbi From sensation to cognition
    M M Mesulam
    Department of Neurology, Northwestern University Medical School, Chicago 60611, USA
    Brain 121:1013-52. 1998
    ..Upstream sectors of unimodal association areas encode basic features of sensation such as colour, motion, form and pitch...
  2. pmc Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats
    Elena O Gracheva
    Department of Physiology, University of California, San Francisco, California 94158 2517, USA
    Nature 476:88-91. 2011
    ..These findings reveal a novel molecular mechanism for physiological tuning of thermosensory nerve fibres...
  3. ncbi Sit-to-stand performance depends on sensation, speed, balance, and psychological status in addition to strength in older people
    Stephen R Lord
    Prince of Wales Medical Research Institute, New South Wales, Australia
    J Gerontol A Biol Sci Med Sci 57:M539-43. 2002
    ..We conducted a study to determine whether sensorimotor, balance, and psychological factors in addition to lower-limb strength predict sit-to-stand performance in older people...
  4. ncbi Time-varied characteristics of acupuncture effects in fMRI studies
    Lijun Bai
    Life Science Research Center, School of Electronic Engineering, Xidian University, Shaanxi, China
    Hum Brain Mapp 30:3445-60. 2009
    ..These findings may pose great implications for the design and interpretation of a range of acupuncture neuroimaging studies...
  5. ncbi Is neocortex essentially multisensory?
    Asif A Ghazanfar
    Program in Neuroscience, Department of Psychology, Green Hall, Princeton University, Princeton, New Jersey, 08540, USA
    Trends Cogn Sci 10:278-85. 2006
    ..Indeed, the multisensory nature of most, possibly all, of the neocortex forces us to abandon the notion that the senses ever operate independently during real-world cognition...
  6. ncbi Neural basis of sensation in intact and injured corneas
    Carlos Belmonte
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez CSIC, Apdo correos 18, 03550 San Juan de Alicante, Spain
    Exp Eye Res 78:513-25. 2004
    ..Presumably, this altered excitability is the origin of the lowered sensitivity and the spontaneous pain, dry eye sensations and other disaesthesias reported in patients following refractive surgery...
  7. pmc A vestibular sensation: probabilistic approaches to spatial perception
    Dora E Angelaki
    Department of Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 64:448-61. 2009
    ..This review highlights what is currently known about the role of vestibular information in these processes, the computations necessary to obtain the appropriate signals, and the benefits that have emerged thus far...
  8. pmc Acupuncture sensation during ultrasound guided acupuncture needling
    Jongbae J Park
    Department of Physical Medicine and Rehabilitation, UNC Chapel Hill, School of Medicine, 1st Floor, North Wing, UNC Hospitals, Campus Box 7200, Chapel Hill, NC 27599, USA
    Acupunct Med 29:257-65. 2011
    Although acupuncture sensation (also known as de qi) is a cornerstone of traditional acupuncture therapy, most research has accepted the traditional method of defining acupuncture sensation only through subjective patient reports rather ..
  9. pmc Perceived harmfulness predicts nonmedical use of prescription drugs among college students: interactions with sensation-seeking
    Amelia M Arria
    Center for Substance Abuse Research, University of Maryland, 4321 Hartwick Rd, Suite 501, College Park, MD 20740, USA
    Prev Sci 9:191-201. 2008
    ..addition, we explore whether the association between perceived harmfulness and nonmedical use varies by level of sensation-seeking...
  10. ncbi Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation
    Jun Chen
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL, USA
    Pain 152:1165-72. 2011
    Despite the increasing interest in TRPA1 channel as a pain target, its role in cold sensation and body temperature regulation is not clear; the efficacy and particularly side effects resulting from channel blockade remain poorly ..
  11. pmc Inside information: the unique features of visceral sensation
    David R Robinson
    Department of Anesthesiology, Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Interv 8:242-53. 2008
    ....
  12. pmc Cellular basis of itch sensation
    Yan Gang Sun
    Departments of Anesthesiology, Psychiatry, and Developmental Biology, Washington University School of Medicine Pain Center, St Louis, MO 63110, USA
    Science 325:1531-4. 2009
    ..Together, the present study suggests that GRPR+ neurons constitute a long-sought labeled line for itch sensation in the spinal cord.
  13. ncbi Acupuncture modulates the limbic system and subcortical gray structures of the human brain: evidence from fMRI studies in normal subjects
    K K Hui
    MGH NMR Center, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston 02129, USA
    Hum Brain Mapp 9:13-25. 2000
    ..gyrus (BA 24), caudate, putamen, temporal pole, and insula in all 11 subjects who experienced acupuncture sensation. In marked contrast, signal increases were observed primarily in the somatosensory cortex...
  14. pmc Brain encoding of acupuncture sensation--coupling on-line rating with fMRI
    Vitaly Napadow
    MGH HMS MIT Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA
    Neuroimage 47:1055-65. 2009
    ..In this fMRI study, subjects were stimulated at acupoint PC-6, while rating sensation with a custom-built, MR-compatible potentiometer...
  15. ncbi Valid across-group comparisons with labeled scales: the gLMS versus magnitude matching
    L M Bartoshuk
    Yale University School of Medicine, P O Box 208041, New Haven, CT 06520 8041, USA
    Physiol Behav 82:109-14. 2004
    ..We generalized an existing scale, the Labeled Magnitude Scale (LMS), by placing the label "strongest imaginable sensation of any kind" at the top...
  16. pmc Effect of a second-generation alpha2delta ligand (pregabalin) on visceral sensation in hypersensitive patients with irritable bowel syndrome
    L A Houghton
    Neurogastroenterology Unit, Academic Division of Medicine and Surgery, University of Manchester, Wythenshawe Hospital, Southmoor Road, Wythenshawe, Manchester M23 9LT, UK
    Gut 56:1218-25. 2007
    ..Pre-clinical studies suggest that the alpha(2)delta ligand pregabalin reduces both visceral allodynia and hyperalgesia, but is inactive on basal sensitivity...
  17. ncbi Development and validation of the Chinese version of the Massachusetts General Hospital Acupuncture Sensation Scale: an exploratory and methodological study
    David Tai Wai Yu
    Physiotherapy Department, Queen Elizabeth Hospital, Hong Kong, China
    Acupunct Med 30:214-21. 2012
    The Massachusetts General Hospital Acupuncture Sensation Scale (MASS) is a tool to measure needle sensations. The aims of the present study were to develop a Chinese version and to assess its psychometric properties.
  18. ncbi Sensation seeking, alcohol use, and sexual behaviors among sexually transmitted infection clinic patients in Cape Town, South Africa
    Seth C Kalichman
    Department of Psychology, University of Connecticut, 406 Babbidge Road, Storrs, CT 06269, USA
    Psychol Addict Behav 20:298-304. 2006
    ..The association between alcohol and sexual risk may be accounted for by sensation seeking personality...
  19. ncbi Interoception: the inside story--a model for psychosomatic processes
    O G Cameron
    University of Michigan Medical Center, Ann Arbor, Michigan 48109 0118, USA
    Psychosom Med 63:697-710. 2001
    ..The objective of this Presidential Address is to review what is known circa the year 2000 of the processes and mechanisms of visceral sensory psychobiology, often called interoception...
  20. ncbi Cognition and sensation in very high static magnetic fields: a randomized case-crossover study with different field strengths
    Angela Heinrich
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, D 68159 Mannheim, Germany
    Radiology 266:236-45. 2013
    ..To establish the extent to which representative cognitive functions in subjects undergoing magnetic resonance (MR) imaging are acutely impaired by static magnetic fields of varying field strengths...
  21. ncbi A Drosophila mechanosensory transduction channel
    R G Walker
    Department of Biology, Howard Hughes Medical Institute, University of California, San Diego, CA 92093 0649, USA
    Science 287:2229-34. 2000
    ..nompC encodes a new ion channel that is essential for mechanosensory transduction. As expected for a transduction channel, D. melanogaster NOMPC and a Caenorhabditis elegans homolog were selectively expressed in mechanosensory organs...
  22. pmc Changing and shielded magnetic fields suppress c-Fos expression in the navigation circuit: input from the magnetosensory system contributes to the internal representation of space in a subterranean rodent
    Tomás Burger
    Department of Zoology, Faculty of Science Charles University in Prague, Vinicna 7, CZ 12844 Praha 2, Czech Republic
    J R Soc Interface 7:1275-92. 2010
    ..Thus, magnetic information may be integrated with multimodal sensory and motor information into a common spatial representation of allocentric space within this circuit...
  23. ncbi Testosterone exposure, dopaminergic reward, and sensation-seeking in young men
    Benjamin C Campbell
    Department of Anthropology, University of Wisconsin Milwaukee, 290 Sabin Hall, 3413 N Downer Ave, Milwaukee, WI 53211, USA
    Physiol Behav 99:451-6. 2010
    To test the relationship between androgen exposure, dopaminergic reward and sensation-seeking, we compared variation in salivary testosterone (T), 2D:4D digit ratio, facial masculinity, Zuckerman's sensation-seeking scale (SSS) and the ..
  24. ncbi The effect of hinge position on corneal sensation and dry eye after LASIK
    Eric D Donnenfeld
    Department of Ophthalmology, Nassau University Medical Center, East Meadow, New York, USA
    Ophthalmology 110:1023-9; discussion 1029-30. 2003
    To investigate the effect of hinge position on corneal sensation and dry eye syndrome after laser in situ keratomileusis (LASIK).
  25. ncbi Test-retest and interobserver reliability of quantitative sensory testing according to the protocol of the German Research Network on Neuropathic Pain (DFNS): a multi-centre study
    Christian Geber
    Klinik und Poliklinik fur Neurologie, Universitätsmedizin der Johannes Gutenberg Universität, Mainz, Germany
    Pain 152:548-56. 2011
    ....
  26. pmc Cryptochrome mediates light-dependent magnetosensitivity in Drosophila
    Robert J Gegear
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 454:1014-8. 2008
    ..Moreover, Cry-dependent magnetosensitivity does not require a functioning circadian clock. Our work provides, to our knowledge, the first genetic evidence for a Cry-based magnetosensitive system in any animal...
  27. pmc Experience-dependent adult cortical plasticity requires cognitive association between sensation and reward
    David T Blake
    Center for Synapses and Cognitive Neuroscience, Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Neuron 52:371-81. 2006
    ..These studies demonstrate that cognitive association between sensory stimuli and reinforcers accompanies adult experience-dependent cortical plasticity and suggest that selectivity in representation and action are linked...
  28. ncbi Impaired pressure sensation in mice lacking TRPV4
    Makoto Suzuki
    Department of Pharmacology, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi, Tochigi 329 0498, Japan
    J Biol Chem 278:22664-8. 2003
    The sensation of pressure, mechanosensation, in vertebrates remains poorly understood on the molecular level. The ion channel TRPV4 is in the TRP family and is a candidate for a mechanosensitive calcium-permeable channel...
  29. pmc Neuronal oscillations and multisensory interaction in primary auditory cortex
    Peter Lakatos
    Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Institute, Orangeburg, NY 10962, USA
    Neuron 53:279-92. 2007
    ..The timing and laminar profile of the multisensory interactions in A1 indicate that nonspecific thalamic systems may play a key role in the effect...
  30. pmc Physiological complexity and system adaptability: evidence from postural control dynamics of older adults
    Brad Manor
    Division of Gerontology, Beth Israel Deaconess Medical Center, 110 Francis St Suite 1B, Boston, MA 02215, USA
    J Appl Physiol (1985) 109:1786-91. 2010
    ..Relatively low baseline complexity may, therefore, indicate control systems that are more vulnerable to cognitive and other stressors...
  31. pmc Semantic confusion regarding the development of multisensory integration: a practical solution
    Barry E Stein
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston Salem, NC 27157 1010, USA
    Eur J Neurosci 31:1713-20. 2010
    ..The current discussion attempts to document some of the more problematic of these, begin a discussion about the nature of the confusion and suggest some possible solutions...
  32. ncbi Representation of pain and somatic sensation in the human insula: a study of responses to direct electrical cortical stimulation
    Karine Ostrowsky
    Hopital Neurologique, Service d Exploration Fonctionnelle Neurologique et d Epileptologie, 59 Bd Pinel, 69003 Lyon, France
    Cereb Cortex 12:376-85. 2002
    ..Finally, lateralization in the right hemisphere of sites where painful sensations were evoked is coherent with the hypothesis of a preponderant role of this hemisphere in species survival...
  33. ncbi A cross-sectional cohort survey in 2100 patients with painful diabetic neuropathy and postherpetic neuralgia: Differences in demographic data and sensory symptoms
    Ralf Baron
    Sektion Neurologische Schmerzforschung und Therapie, Klinik fur Neurologie, Universitatsklinikum Schleswig Holstein, Campus Kiel, Schittenhelmstr 10, 24105 Kiel, Germany
    Pain 146:34-40. 2009
    ..Patient-Reported Outcomes can be used to obtain a precise sensory characterization of each patient...
  34. pmc Cortical circuits for perceptual inference
    Karl Friston
    The Wellcome Trust Centre of Neuroimaging, University College London, Queen Square, London, United Kingdom
    Neural Netw 22:1093-104. 2009
    ..We then show that the brain has the necessary infrastructure to implement this inversion and present stimulations using synthetic birds that generate and recognise birdsongs...
  35. ncbi Illusion of sense of self-agency: discrepancy between the predicted and actual sensory consequences of actions modulates the sense of self-agency, but not the sense of self-ownership
    Atsushi Sato
    Department of Psychosomatic Medicine, The University of Tokyo Hospital, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Cognition 94:241-55. 2005
    It is proposed that knowledge of motor commands is used to distinguish self-generated sensation from externally generated sensation...
  36. ncbi The autonomous bladder: a view of the origin of bladder overactivity and sensory urge
    J I Gillespie
    Urophysiology Research Group, School of Surgical and Reproductive Sciences, Medical School, University, Newcastle upon Tyne, UK
    BJU Int 93:478-83. 2004
    ..The purpose of this short review is to raise questions and re-visit ideas from some older possibly forgotten and neglected publications, but which may shed new light on this problem...
  37. pmc Characterization of the "deqi" response in acupuncture
    Kathleen K S Hui
    Athinoula A, Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    BMC Complement Altern Med 7:33. 2007
    ....
  38. ncbi Sensory control and organization of neural networks mediating coordination of multisegmental organs for locomotion
    Ansgar Buschges
    Dept Animal Physiol Zoological Institute, Univiversity of Cologne, Cologne, Germany
    J Neurophysiol 93:1127-35. 2005
    ....
  39. ncbi Brief report: sensory abnormalities as distinguishing symptoms of autism spectrum disorders in young children
    Lisa D Wiggins
    Department of Psychology, Georgia State University, Atlanta, GA 30333, USA
    J Autism Dev Disord 39:1087-91. 2009
    ..Results also suggest that sensory abnormalities are distinguishing symptoms of ASD that should be considered in diagnostic algorithms for younger cohorts...
  40. ncbi Residual function in peripheral nerve stumps of amputees: implications for neural control of artificial limbs
    Gurpreet S Dhillon
    Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA
    J Hand Surg Am 29:605-15; discussion 616-8. 2004
    ....
  41. ncbi Acupuncture needling sensation: the neural correlates of deqi using fMRI
    Aziz U R Asghar
    York Neuroimaging Centre, University of York, Y10 5DG, UK
    Brain Res 1315:111-8. 2010
    The needling sensation of deqi is considered by most acupuncturists to be an important component of acupuncture, yet neuroimaging research that investigates this needle sensation has been limited...
  42. ncbi The relationship between cognition and sensation in determining when and where to void: the concept of cognitive voiding
    Joan Harvey
    School of Psychology, Newcastle University, Newcastle upon Tyne, UK
    BJU Int 110:1756-61. 2012
    ..OBJECTIVE • To investigate the inter-relationship between conscious decision-making processes and bladder sensation in determining the need, time and place to void
  43. ncbi Does the effect of acupuncture depend on needling sensation and manipulation?
    Yu Jin Choi
    Department of Neuropsychiatry, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea
    Complement Ther Med 21:207-14. 2013
    Acupuncture sensation and manipulation have been considered to be an important component of acupuncture in traditional Asian medicine...
  44. ncbi ERP correlates of action effect prediction and visual sensory attenuation in voluntary action
    Gethin Hughes
    Laboratoire Psychologie de la Perception, Universite Paris Descartes, Paris, France
    Neuroimage 56:1632-40. 2011
    ..Taken together, these findings help to elucidate the cortical mechanisms of voluntary action as well as their sensory consequences and inform how our interaction with the external world is processed and controlled...
  45. pmc Design and performance of a multichannel vestibular prosthesis that restores semicircular canal sensation in rhesus monkey
    Bryce Chiang
    Emory School of Medicine, Atlanta, GA 30322, USA
    IEEE Trans Neural Syst Rehabil Eng 19:588-98. 2011
    ..Bilateral loss of vestibular sensation causes chronic disequilibrium, oscillopsia, and postural instability...
  46. ncbi Overlapping activity in anterior insula during interoception and emotional experience
    Jamil Zaki
    Department of Psychology, Harvard University Cambridge, MA 02138, USA
    Neuroimage 62:493-9. 2012
    ..Together, these data further clarify the functional role of the anterior insula and provide novel insights about the connection between bodily awareness and emotion...
  47. ncbi Rectal sensation test helps avoid pain of apical prostate biopsy
    J Stephen Jones
    Glickman Urological Institute, Cleveland Clinic Foundation, Ohio 44195, USA
    J Urol 170:2316-8. 2003
    ..Apical cores obtained during transrectal prostate biopsy are associated with greater pain than cores obtained from the remainder of the gland. We present a method to minimize this pain...
  48. ncbi Early changes in corneal sensation, ocular surface integrity, and tear-film function after laser-assisted subepithelial keratectomy
    Jutta Horwath-Winter
    Department of Ophthalmology, University of Graz, Graz, Austria
    J Cataract Refract Surg 30:2316-21. 2004
    To investigate the changes in corneal sensation, ocular surface integrity, and tear-film function after laser-assisted subepithelial keratectomy (LASEK).
  49. pmc Who multi-tasks and why? Multi-tasking ability, perceived multi-tasking ability, impulsivity, and sensation seeking
    David M Sanbonmatsu
    Department of Psychology, University of Utah, Salt Lake City, Utah, United States of America
    PLoS ONE 8:e54402. 2013
    ..of Utah completed measures of multi-tasking activity, perceived multi-tasking ability, impulsivity, and sensation seeking...
  50. ncbi Corneal barrier function, tear film stability, and corneal sensation after photorefractive keratectomy and laser in situ keratomileusis
    Ryohei Nejima
    Meiwakai Medical Foundation, Miyata Eye Hospital, Miyazaki, Japan
    Am J Ophthalmol 139:64-71. 2005
    To compare corneal sensation, corneal barrier function, tear secretion, and tear film stability after photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK).
  51. ncbi Pathways of sensory recovery after face transplantation
    Maria Siemionow
    Dermatology and Plastic Surgery Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Plast Reconstr Surg 127:1875-89. 2011
    ..Evidence from published reports on the first four face transplant recipients indicates improved and accelerated return of sensation to the facial allograft despite suboptimal repair of the sensory nerves.
  52. ncbi Brain networks encoding rectal sensation in type 1 diabetes
    D Lelic
    Mech Sense, Department of Gastroenterology and Hepatology, Aalborg Hospital, Aarhus University, Denmark
    Neuroscience 237:96-105. 2013
    ..In order to find less invasive stimuli to study visceral afferent processing and to further elaborate the gut-brain network in diabetes, we studied brain networks following rectal electrical stimulations...
  53. pmc Reduced prefrontal and temporal processing and recall of high "sensation value" ads
    Daniel D Langleben
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Neuroimage 46:219-25. 2009
    ..Message sensation value" (MSV), a measure of sensory intensity of audio, visual, and content features of an ad, is an important ..
  54. pmc Neurophysiological evidence for context-dependent encoding of sensory input in human auditory cortex
    Elyse Sussman
    Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway South, NY 10461, USA
    Brain Res 1075:165-74. 2006
    ..The results demonstrate that context-dependent sound representations modulate stimulus-dependent neural encoding at early stages of auditory cortical processing...
  55. ncbi Multisensory integration: current issues from the perspective of the single neuron
    Barry E Stein
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Nat Rev Neurosci 9:255-66. 2008
    ..Here we examine some of the fundamental advances that have been made and some of the challenging questions that remain...
  56. ncbi Effect of hinge position on corneal sensation and dry eye after laser in situ keratomileusis using a femtosecond laser
    Shahzad I Mian
    Department of Ophthalmology and Visual Sciences, W K Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, Michigan 48105, USA
    J Cataract Refract Surg 33:1190-4. 2007
    To determine whether hinge position has an effect on corneal sensation and dry-eye symptoms after myopic laser in situ keratomileusis (LASIK) performed with the IntraLase femtosecond laser (IntraLase Corp.).
  57. ncbi Topical high-concentration (40%) menthol-somatosensory profile of a human surrogate pain model
    Andreas Binder
    Division of Neurological Pain Research and Therapy, Christian Albrechts Universitat Kiel, Kiel, Germany
    J Pain 12:764-73. 2011
    ..The data suggest that topical 40% menthol application is a useful model for studies of cold hyperalgesia and pinprick hyperalgesia in humans...
  58. pmc Synchrony in sensation
    Randy M Bruno
    Department of Neuroscience and the Kavli Institute for Brain Science, Columbia University, New York, NY 10032, USA
    Curr Opin Neurobiol 21:701-8. 2011
    ..The prevalence of strong feedforward inhibitory circuits throughout the central nervous system suggests that synchrony codes and timing-sensitive circuits may be widespread, occurring well beyond sensory thalamus and cortex...
  59. pmc Foot anatomy specialization for postural sensation and control
    W G Wright
    Temple University, Philadelphia, PA, USA
    J Neurophysiol 107:1513-21. 2012
    ..In conclusion, the architecture and physiology of the foot appear to contribute to the task of bipedal postural control with great sensitivity...
  60. ncbi Effects of chronic median nerve compression at the wrist on sensation and manual skills
    J Thonnard
    Unite de Readaptation et de medecine physique, Universite Catholique de Louvain, 53 avenue Mounier, Tour Pasteur, B 5375 Brussels, Belgium
    Exp Brain Res 128:61-4. 1999
    ..study was to analyse the functional impairments caused by chronic median nerve compression at the wrist on hand sensation and manual skill...
  61. ncbi Effect of viral upper respiratory tract infection on the urge-to-cough sensation
    Peter V Dicpinigaitis
    Albert Einstein College of Medicine, Montefiore Medical Center, 1825 Eastchester Road, Bronx, NY, USA
    Respir Med 105:615-8. 2011
    Recently, interest has emerged in the sensation of irritation that precedes the motor act of coughing; this phenomenon has been termed the urge-to-cough (UTC)...
  62. pmc Vibrissa sensation in superior colliculus: wide-field sensitivity and state-dependent cortical feedback
    Jeremy D Cohen
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci 28:11205-20. 2008
    ..In addition, their output is most robust during quiescent states because of the dependence of cortical feedback on forebrain activation, and this may serve as an alerting signal to drive orienting responses...
  63. pmc Pain mechanisms: a commentary on concepts and issues
    Edward R Perl
    Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7545, United States
    Prog Neurobiol 94:20-38. 2011
    ..pain is aimed at providing perspective for a reader who does not work in the field of mammalian somatic sensation. It is not a comprehensive review of the literature...
  64. pmc Deqi sensations without cutaneous sensory input: results of an RCT
    Norbert Salih
    Multidisciplinary Pain Center, Department of Anesthesiology, University of Munich, Munich, Germany
    BMC Complement Altern Med 10:81. 2010
    ..Therefore, we aim to further analyze whether the perceptions reported in the two study arms were distinguishable and whether expectancy effects exhibited considerable impact on our results...
  65. pmc Corneal sensation and subbasal nerve alterations in patients with herpes simplex keratitis: an in vivo confocal microscopy study
    Pedram Hamrah
    Massachusetts Eye and Ear Infirmary, Cornea Service and Ocular Surface Imaging Center, Department of Ophthalmology, Harvard Medical School, Boston, Massachusett 02114, USA
    Ophthalmology 117:1930-6. 2010
    To study and correlate corneal sensation in patients with herpes simplex keratitis (HSK) with density and morphologic features of subbasal corneal nerves by in vivo confocal microscopy (IVCM).
  66. ncbi Studying sensorimotor integration in insects
    Stephen J Huston
    19700 Helix Drive, Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, United States
    Curr Opin Neurobiol 21:527-34. 2011
    ..Here we present some studies using insect model systems that have produced insights, at the level of individual neurons, about sensorimotor integration and the various ways in which it can be modified by context...
  67. pmc Operant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5)
    Christopher M Olsen
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 5:e15085. 2010
    ..to use mGluR5 knockout (KO), heterozygous (Het), and wildtype (WT) mice to determine if mGluR5 modulates operant sensation seeking (OSS), an operant task that uses varied sensory stimuli as a reinforcer...
  68. ncbi Rubber hands feel the touch of light
    Frank H Durgin
    Swarthmore College, PA 19081, USA
    Psychol Sci 18:152-7. 2007
    ..The illusion may be experienced on one's real hand as well. The results are discussed in terms of multisensory integration...
  69. ncbi Enhanced sensory relearning after nerve repair by using repeated forearm anaesthesia: aspects on time dynamics of treatment
    G Lundborg
    Department of Clinical Sciences Hand Surgery, Malmo University Hospital, Malmo, Sweden
    Acta Neurochir Suppl 100:121-6. 2007
    ..In healthy individuals selective anaesthesia of the forearm results in improved hand sensation. Here we hypothesised that this principle would be valid also after nerve injury and repair.
  70. ncbi Avoiding incidental predation by mammalian herbivores: accurate detection and efficient response in aphids
    Moshe Gish
    Department of Evolutionary and Environmental Biology, University of Haifa, Haifa, Israel
    Naturwissenschaften 98:731-8. 2011
    ..The accurate and efficient defense mechanism of U. sonchi emphasizes the significance of incidental predation as a danger to plant-dwelling invertebrates...
  71. pmc Odd sensation induced by moving-phantom which triggers subconscious motor program
    Takao Fukui
    NTT Communication Science Laboratories, Nippon Telegraph and Telephone Corporation, Morinosato, Atsugi, Kanagawa, Japan
    PLoS ONE 4:e5782. 2009
    ..is the action of stepping onto a stopped escalator, which causes clumsy movements accompanied by an odd sensation. Previous studies have examined short-term sensorimotor adaptations to treadmills and moving sleds, but the ..
  72. ncbi Double nerve intraneural interface implant on a human amputee for robotic hand control
    Paolo M Rossini
    Dept of Neurology, University Campus Bio Medico, Rome, Italy
    Clin Neurophysiol 121:777-83. 2010
    ..Aim of this study is to evaluate a novel peripheral intraneural multielectrode for multi-movement prosthesis control and for sensory feed-back, while assessing cortical reorganization following the re-acquired stream of data...
  73. pmc Development of multisensory reweighting for posture control in children
    Woei Nan Bair
    Department of Kinesiology, University of Maryland at College Park, College Park, MD 20742 2611, USA
    Exp Brain Res 183:435-46. 2007
    ....
  74. pmc Predicting sensation seeking from dopamine genes. A candidate-system approach
    Jaime Derringer
    Department of Psychology, University of Minnesota, Minneapolis, MN 55455, USA
    Psychol Sci 21:1282-90. 2010
    b>Sensation seeking is a heritable personality trait that has been reliably linked to behavioral disorders...
  75. ncbi Cortical processing of human somatic and visceral sensation
    Q Aziz
    Department of Clinical Neurosciences, Institute of Psychiatry, London SE5 8AF, United Kingdom
    J Neurosci 20:2657-63. 2000
    Somatic sensation can be localized precisely, whereas localization of visceral sensation is vague, possibly reflecting differences in the pattern of somatic and visceral input to the cerebral cortex...
  76. pmc Tuning curves, neuronal variability, and sensory coding
    Daniel A Butts
    Division of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS Biol 4:e92. 2006
    ....
  77. ncbi HEN-1, a secretory protein with an LDL receptor motif, regulates sensory integration and learning in Caenorhabditis elegans
    Takeshi Ishihara
    Structural Biology Center, National Institute of Genetics, Mishima, Japan
    Cell 109:639-49. 2002
    ..defects in the integration of two sensory signals and in behavioral plasticity by paired stimuli, although their sensation capability seems to be identical to that of the wild-type...
  78. ncbi Southampton needle sensation questionnaire: development and validation of a measure to gauge acupuncture needle sensation
    Peter White
    School of Health Professions and Rehabilitation Sciences, University of Southampton, Southampton, UK
    J Altern Complement Med 14:373-9. 2008
    ..The aim of this study was to generate and validate a new sensation questionnaire, that was able to discriminate between pain and deqi, taking into account patient experience and ..
  79. pmc Acupuncture modulates temporal neural responses in wide brain networks: evidence from fMRI study
    Lijun Bai
    Medical Image Processing Group, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China
    Mol Pain 6:73. 2010
    ....
  80. ncbi On the origins of the sensory output from the bladder: the concept of afferent noise
    James I Gillespie
    The Uro physiology Research Group, The Medical School, The University, Newcastle upon Tyne, UK
    BJU Int 103:1324-33. 2009
    ..It focuses on overt bladder contractions rather than the main problem, which is altered and heightened sensation. Also, current approaches that describe bladder sensations as episodic and leading to voiding as 'first and ..
  81. ncbi Regional brain activation during proximal stomach distention in humans: A positron emission tomography study
    Joris Vandenbergh
    Division of Liaison Psychiatry, Department of Psychiatry, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Gastroenterology 128:564-73. 2005
    ..The aim of this study was to investigate regional brain activation during painful and nonpainful proximal gastric distention in humans...
  82. ncbi Adaptive procedures in psychophysical research
    M R Leek
    Army Audiology and Speech Center, Walter Reed Army Medical Center, Washington, DC 20307 5001, USA
    Percept Psychophys 63:1279-92. 2001
    As research on sensation and perception has grown more sophisticated during the last century, new adaptive methodologies have been developed to increase efficiency and reliability of measurement...
  83. ncbi The Drosophila larva as a model for studying chemosensation and chemosensory learning: a review
    Bertram Gerber
    Universitat Wurzburg, Biozentrum, Am Hubland, Lehrstuhl für Genetik und Neurobiologie, D 97074 Wurzburg, Germany
    Chem Senses 32:65-89. 2007
    ....
  84. pmc Somatosensory function in speech perception
    Takayuki Ito
    Haskins Laboratories, 300 George Street, New Haven, CT 06511, USA
    Proc Natl Acad Sci U S A 106:1245-8. 2009
    ....
  85. ncbi Analgesia through the looking-glass? A randomized controlled trial investigating the effect of viewing a 'virtual' limb upon phantom limb pain, sensation and movement
    Eric E Brodie
    Department of Psychology, Glasgow Caledonian University, Glasgow G4 0BA, UK
    Eur J Pain 11:428-36. 2007
    ..The potential of a 'virtual' limb as a treatment for phantom limb pain was discussed in terms of its ability to halt and/or reverse the cortical re-organisation of motor and somatosensory cortex following acquired limb loss...
  86. pmc A role for nociceptive, myelinated nerve fibers in itch sensation
    Matthias Ringkamp
    Department of Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Neurosci 31:14841-9. 2011
    Despite its clinical importance, the underlying neural mechanisms of itch sensation are poorly understood...
  87. pmc Novel pharmacology: asimadoline, a kappa-opioid agonist, and visceral sensation
    M Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic, Rochester, MN 55905, USA
    Neurogastroenterol Motil 20:971-9. 2008
    ..It acts as a complete agonist in in vitro assay. Asimadoline reduced sensation in response to colonic distension at subnoxious pressures in healthy volunteers and in irritable bowel syndrome (..
  88. pmc Sensory axon-derived neuregulin-1 is required for axoglial signaling and normal sensory function but not for long-term axon maintenance
    Florence R Fricker
    Wolfson Centre for Age Related Diseases, King s College London, Guy s Campus, London SE1 1UL, United Kingdom
    J Neurosci 29:7667-78. 2009
    ..Sensory neuronal survival and axonal maintenance, however, are not dependent on axon-derived neuregulin-1 signaling in adulthood...
  89. ncbi Bloating and distention in irritable bowel syndrome: the role of visceral sensation
    Anurag Agrawal
    Neurogastroenterology Unit, University of Manchester, Manchester, United Kingdom
    Gastroenterology 134:1882-9. 2008
    ..A number of mechanisms have been postulated for bloating and distention, but the role of visceral sensation, which is often abnormal in IBS, has not been previously investigated, and this study aimed to address this ..
  90. ncbi From sensation to action
    Ranulfo Romo
    Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, 04510 Mexico, DF, Mexico
    Behav Brain Res 135:105-18. 2002
    ..We also discuss recent results that suggest how the somatosensory stimuli are represented in the brain during short-term memory. Finally, we review data that show the neuronal correlates of a decision during somatosensory perception...
  91. ncbi Functional neuroimaging of visceral sensation
    Q Aziz
    Department of Gastrointestinal Science, University of Manchester, UK
    J Clin Neurophysiol 17:604-12. 2000
    ..imaging techniques has led to considerable advances in our understanding of brain processing of human visceral sensation. The use of complementary techniques such as functional MRI, positron emission tomography, ..
  92. ncbi Sensation of bloating and visible abdominal distension in patients with irritable bowel syndrome
    L Chang
    CURE/Digestive Disease Research Center, University of California Los Angeles, Westwood 90024, USA
    Am J Gastroenterol 96:3341-7. 2001
    ..Although the sensation of bloating may be related to enhanced sensitivity to visceral afferent stimulation, abdominal distension in ..
  93. ncbi Multisensory processing via early cortical stages: Connections of the primary auditory cortical field with other sensory systems
    E Budinger
    Leibniz Institute for Neurobiology, Department of Auditory Learning and Speech, Brenneckestrasse 6, D 39118 Magdeburg, Germany
    Neuroscience 143:1065-83. 2006
    ..the somatosensory and olfactory ones) multisensory information is probably also processed in these cortices. This suggests more generally, that primary sensory cortices may not be unimodal...
  94. ncbi The effect of punctal occlusion on tear production, tear clearance, and ocular surface sensation in normal subjects
    M T Yen
    Ocular Surface and Tear Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, USA
    Am J Ophthalmol 131:314-23. 2001
    ..To evaluate the effect of temporary punctal occlusion on tear production, tear clearance, and ocular surface sensation in normal subjects. METHODS: Noncomparative interventional case series...
  95. ncbi Genital sensation after feminizing genitoplasty for congenital adrenal hyperplasia: a pilot study
    N S Crouch
    Department of Obstetrics and Gynaecology, Elizabeth Garrett Anderson and Obstetric Hospital, University College London Hospitals, London, UK
    BJU Int 93:135-8. 2004
    To assess sensation in the clitoris and vagina in women with congenital adrenal hyperplasia (CAH) who have previously had genital surgery, and to evaluate sexual function in this group as the latter, and particularly the experience of ..
  96. ncbi The water load test: observations from healthy controls and patients with functional dyspepsia
    Michael P Jones
    Division of Gastroenterology and Hepatology, Northwestern University Medical School, Chicago, Illinois 60611 2908, USA
    Am J Physiol Gastrointest Liver Physiol 284:G896-904. 2003
    Gastric sensation and accommodation are studied by barostat, but this is invasive. The drink test is noninvasive and may provide similar information...
  97. ncbi Basic and clinical aspects of visceral sensation: transmission in the CNS
    K Bielefeldt
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neurogastroenterol Motil 17:488-99. 2005
    ..Drugs, surgical and non-pharmacological treatments can target these pathways and provide therapeutic options for patients with chronic visceral pain syndromes...
  98. ncbi Probability and amplitude of novelty responses as a function of the change in contrast of the reafferent image in G carapo
    A A Caputi
    Department of Neurofisiología Comparada, Instituto de Investigaciones Biologicas Clemente Estable, Associated Unit of Facultad de Ciencias, Av Italia 3318, Montevideo, Uruguay, CP 11600
    J Exp Biol 206:999-1010. 2003
    ..We conclude that contrast discrimination in the electrosensory system of G. carapo obeys the general principle of appreciating any instantaneous input by the input's departure from a moving average of past images...
  99. ncbi Rectal compliance and rectal sensation in constipated adolescents, recovered adolescents and healthy volunteers
    M M van den Berg
    Emma Children s Hospital Academic Medical Centre, Department of Pediatric Gastroenterology and Nutrition, Room C2 312, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Gut 57:599-603. 2008
    ..Abnormal rectal function due to increased distensibility (compliance) might be an underlying mechanism of therapy-resistant FC. It is hypothesised that rectal compliance is normal in patients who are successfully recovered from FC (RC)...
  100. ncbi Somatotopic blocking of sensation with navigated transcranial magnetic stimulation of the primary somatosensory cortex
    Henri Hannula
    Nexstim Ltd, Helsinki, Finland
    Hum Brain Mapp 26:100-9. 2005
    ..electric field, we found that TMS of a spatially restricted cortical S1 thenar area is sufficient to abolish sensation from a weak electric stimulation of the corresponding skin area...
  101. ncbi Applied principles of neurogastroenterology: physiology/motility sensation
    John E Kellow
    Department of Medicine, Royal North Shore Hospital, University of Sydney, Sydney, Australia
    Gastroenterology 130:1412-20. 2006
    ..Based on the conceptual framework established to date, a number of recommendations for further progress can be made...

Research Grants75

  1. The gastric X/A-like (ghrelin) cell: A peripheral regulator of food intake
    NILS WG LAMBRECHT; Fiscal Year: 2012
    ..The mechanisms leading to the sensation of appetite and the release of gastrointestinal hormones in response to meal stimuli play an important role in ..
  2. EXPRESSION PROFILES FOR RET-POSITIVE DRG NEURONS
    Sanjay Jain; Fiscal Year: 2013
    ..as painful bladder syndrome or interstitial cystitis (IC/PBS), they participate in both somatic and visceral sensation, express key ion channels that are implicated in somatic and visceral pain (TrpV1, TrpA1), and GFLs can produce ..
  3. PKC delta and cell renewal in irradiated taste epithelium
    MARY ELAINE REYLAND; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Taste dysfunction, either loss or alteration in sensation, is a common occurrence during radiotherapy for head and neck cancer...
  4. Novel genetics, pathobiology &therapy of nephronophthisis-related ciliopathies
    Friedhelm Hildebrandt; Fiscal Year: 2013
    ..organisms to humans, for cellular sensory tasks, including photo-, mechano-, thermo-, olfactory, and hormonal sensation. By identification of the NPHP1-9 genes we implicated non-canonical Wnt signaling, hedgehog signaling, and cell ..
  5. CIRCUITS MEDIATING BEHAVIORAL CONSEQUENCES OF STEROID SENSATION
    Timothy E Holy; Fiscal Year: 2013
    ..Olfactory detection may represent a major, previously-unrecognized mechanism for steroid action in mice;understanding this phenomenon will provide critical new insights for interpreting studies that alter the steroid milieu. ..
  6. The role of trace metals and T-channels in pain
    Slobodan M Todorovic; Fiscal Year: 2013
    ..metals that can increase cellular excitability of nociceptive DRG and DH neurons and consequently modulate pain sensation by potentiating function of CaV3.2 channels...
  7. Genetic Mapping Of Novel Molecular Players in Itch
    RACHEL BETH BREM; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The somatosensory system mediates pruritus, or itch, the unpleasant sensation that evokes a desire to scratch...
  8. Spinal Cord-Mediated Acute Neurogenic Inflammation
    Qing Lin; Fiscal Year: 2010
    ..been known to be initiated by release of inflammatory substances from sensory nerve terminals by which painful sensation may be caused and even exacerbated...
  9. Oral Immunobiology of MCMV-infected Mouse Salivary Glands
    Steven D London; Fiscal Year: 2010
    ..resulting in diminished salivary output and/or altered salivary composition results in the subjective sensation of dry mouth (xerostomia)...
  10. Vestibular rehabilitation and dizziness in geriatric patients
    Courtney Hall; Fiscal Year: 2012
    ..Dizziness represents a diagnostic and treatment challenge for clinicians because it is a subjective sensation, can refer to a variety of symptoms (unsteadiness, spinning, a sense of movement or lightheadedness), and has a ..
  11. Brain aromatase availability in steroid users: PET studies with [11C]vorozole
    Thomas B Hildebrandt; Fiscal Year: 2013
    ..and behavioral measures of the AAS intoxication syndrome (aggression, sexual activity, impulsivity, and sensation seeking) in AAS users...
  12. Mechanism and functional role of AKAP79/150 in M current control
    Mark S Shapiro; Fiscal Year: 2012
    ..mechanisms endowing AKAP79/150 in organizing the transcriptional regulation of M-type K+ channels, and in orchestrating the receptor signaling towards these channels in sensory neurons that are pivotal in control of visceral sensation.
  13. Predicting cell deformation from body level mechanical loads
    Ahmet Erdemir; Fiscal Year: 2012
    ..At a lower level, mechanical sensation of cell deformations regulate movement control...
  14. Development and Functional Analysis of Components of the Zebrafish Serotonin Sign
    Kenneth N Wallace; Fiscal Year: 2012
    ..Primary afferent extrinsic neurons on the other hand communicate with the CNS to create visceral sensation. 5-HT is charged at physiological pH and must be removed by transport across cellular membranes using the ..
  15. Mechanisms of glucosensation mediating food choice behavior in Drosophila
    Monica Dus; Fiscal Year: 2013
    ..In this proposal I present a focused strategy to characterize the function of the fly candidate dSGLT in glucose-sensation and behavior...
  16. Exploiting toxins to probe sensory signaling
    David Julius; Fiscal Year: 2012
    ..and ion channels that contribute to the detection of sensory stimuli, particularly in relationship to pain sensation. Results from this work will provide a more in-depth understanding of how these receptors and channels respond ..
  17. Excitability of afferents evoking the exercise pressor reflex
    Victor Ruiz-Velasco; Fiscal Year: 2013
    ..excitability of the thin fiber muscle afferents that evoke the exercise pressor reflex as well as transduce the sensation of pain...
  18. Lipid Mediators in Corneal Nerve Regeneration
    Haydee E P Bazan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Alterations in corneal innervation result in impaired corneal sensation, severe dry eye and damage to the epithelium that may in turn lead to corneal ulcers, melting and perforation...
  19. Skin Temperature Perception and Prosthetic Thermoregulation
    GLENN KLUTE; Fiscal Year: 2012
    ..Amputee thermoregulation may be further complicated by neuronal degradation impairing temperature sensation and vasomotor response...
  20. Auditory Cortex Plasticity and Tinnitus
    Brian Allman; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Tinnitus, a subjective perception of a phantom auditory sensation (e.g., ringing in the ears), affects approximately 10-15% of the general population...
  21. Using Electrochemical Methods to Probe Neuronal Signaling in the GI Tract
    Greg M Swain; Fiscal Year: 2010
    ..Many functional GI disorders, such as disturbances in motility, absorption/secretion and sensation that do not have an identifiable pathophysiological basis, are thought to be related to dysfunction in ..
  22. Respiratory Muscle Weakness in Chronic Inflammation
    Francisco H Andrade; Fiscal Year: 2013
    ..This promotes the debilitating sensation of breathlessness, decreases exercise tolerance, and can lead to respiratory failure...
  23. Integrative Neural Systems Underlying Vital Aerodigestive Tract Functions
    Joanne Robbins; Fiscal Year: 2010
    ..underpinnings of swallowing, sleep, respiration and vocalization, critical functions with overarching issues of sensation, cognition/volitional control and imaging...
  24. Novel transgenic reporter/deleter allele for Type I taste cells
    Sue Kinnamon; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Taste buds are the transducing elements of gustatory sensation. As such, they represent the first step in the process by which nutritious substances, such as Na+ salts, sugars, and amino acids can be ..
  25. Cyclosporine in Interstitial Cystitis: Efficacy, Safety and Mechanism of Action
    Daniel Shoskes; Fiscal Year: 2013
    ..Hyperalgesia will be assessed for sensation perception and pain threshold at 3 frequencies that measure function of 3 nerve types (C, A-delta, A-beta fibers)..
  26. Mechanisms of Cancer Treatment Related Symptoms
    Lisa J Wood; Fiscal Year: 2013
    ..These symptoms can greatly influence the subjective sensation of cancer treatment related fatigue (CTRF) which is the most common and distressing CTRS, and one that has a ..
  27. Cystitis-Induced Plasticity of Micturitin Reflexes
    MARGARET ANN VIZZARD; Fiscal Year: 2013
    ..the life of this grant, we have hypothesized that pain associated with BPS/IC involves an alteration of visceral sensation/bladder sensory physiology...
  28. Human Umami Taste: Genetics of Psychophysical Traits
    Paul A S Breslin; Fiscal Year: 2012
    ..goal of the proposed work is to elucidate genetic and molecular mechanisms that are responsible for the human sensation of `umami'taste...
  29. Integration of Immunochemical, Genomic & Transcriptomic Analyses of Human Skin
    FRANK LAMBERT contact RICE; Fiscal Year: 2010
    ..their recent immunochemical findings have shown that keratinocytes in the epidermis play a direct role in skin sensation, and that pathologies in the epidermal chemistry likely contribute to chronic pain...
  30. Transgenic Tethered Peptides
    Michael N Nitabach; Fiscal Year: 2013
    ..are key regulators of many developmental, physiological, and behavioral processes: metabolism, lifespan, pain sensation, circadian rhythms, sleep, sexual behavior, etc...
  31. Role of taste signaling elements in enteroendocrine cells
    Robert F Margolskee; Fiscal Year: 2013
    ..release of GLP-1, suggesting that the defect in 1-gustducin knockout mice in vivo is at the level of glucose sensation. The experiments proposed here aim to further characterize the functions of gustducin, T1R3 and other taste ..
  32. Role of the TRPV1 channel in myocardial salvage from ischemia-reperfusion injury
    ERIC RICHARD GROSS; Fiscal Year: 2012
    ..Is the pain sensation generated by TRPV1 activation linked to a pathway which protects from heart attacks? Diabetes, which increases ..
  33. STIMULATION-AUGMENTED EXERCISE AND NEUROMOTOR THERAPY
    Eric C Hartman; Fiscal Year: 2010
    ..controller;2) functional stimulation levels could be well tolerated in this population where cutaneous sensation is in-tact (potentially hypersensitive);and 3) the stimulation controller could accommodate client volitional ..
  34. A New Device for Rapid Measurement of Touch Sensation in neuropathy
    Donald A Simone; Fiscal Year: 2010
    ..In neuropathy, sensory dysfunction almost always begins in the distal extremities (fingers or toes) where the sensation of touch is diminished or lost...
  35. Excitation contraction coupling in bladder smooth muscle
    Robert S Moreland; Fiscal Year: 2013
    ..interfere with the quality of life, with lower urinary tract symptoms such as frequent urination, the sensation of incomplete bladder emptying, interrupted orweak urinary stream, and urinary leakage...
  36. Producing micturition by combined afferent and effernet electrical stimulation
    Kenneth J Gustafson; Fiscal Year: 2010
    ..Other effects of the rhizotomy (loss of remaining sensation, reflex sexual function and reflex defecation) limit the clinical acceptance of this procedure...
  37. Identification of a Stretch-Activated Channel with a Role in Cardiac Development
    Dipayan Chaudhuri; Fiscal Year: 2013
    ..observed electrophysiologically in neonatal/adult cardiovascular tissue, and perhaps play a role in pressure sensation. Nevertheless, study of this mechanism has been hindered by our ignorance of the identity of the channels ..
  38. Molecular basis for the regulation of G protein-coupled receptor kinases
    John J G Tesmer; Fiscal Year: 2012
    ..receptors (GPCRs) are key regulators of cell physiology, controlling processes that range from the sensation of light to the contractility of the heart...
  39. Identification, Development and Function of Rapidly Adapting Mechanoreceptors
    Wenqin Luo; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Touch sensation, including the perception of form and texture, is essential for our daily lives...
  40. Developing a Skin Toxicity-Related Quality of Life Scale for Breast Radiotherapy
    Julie B Schnur; Fiscal Year: 2012
    ..Skin toxicity can affect multiple aspects of quality of life (QOL) including sensation (pain, itching, burning), body image, emotional well-being, lifestyle, and treatment satisfaction...
  41. Electrical Stimulation to Restore Three Dimensional Vestibular Sensation
    Charles C Della Santina; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Bilateral loss of vestibular function (inner ear balance sensation) due to ototoxic hair cell injury is disabling, with patients suffering disequilibrium and inability to maintain stable vision ..
  42. Modulation of Pruritus by Spinal Cannabinoids
    Gregory W Terman; Fiscal Year: 2010
    ..Recently, we have found that, like nociception, itch sensation, also appears to be increased in animals previously exposed to repeated morphine injections - although this ..
  43. Cervical spinal injury and demyelination in aged rats
    Michael S Beattie; Fiscal Year: 2010
    ..neurological outcome measures, including forelimb motor function tests and tests for the development of altered sensation (e.g. allodynia and pain)...
  44. Zeiss LSM 710 confocal microscope
    Jaime Grutzendler; Fiscal Year: 2010
    ..cellular mechanisms of dementia, multiple sclerosis pathogenesis, molecular basis of hearing and somatic sensation and retinal physiology...
  45. The Role of Perineurial Glia in PNS Regeneration
    GWENDOLYN LEWIS; Fiscal Year: 2013
    ..When peripheral nerves become injured, the connection between the CNS and tissues is severed, causing sensation and motor control to be lost...
  46. EMG Biofeedback with AMES
    Paul Cordo; Fiscal Year: 2010
    ..a novel therapeutic regimen and robotic device called "AMES," an acronym for Assisted Movement with Enhanced Sensation. In AMES-as it is currently used-the patient's affected limb is moved cyclically with the AMES robotic ..
  47. The GE PETtrace Cyclotron: A Scientific Resource for the State of Arizona
    Eric M Reiman; Fiscal Year: 2010
    ..It made major contributions to the study of memory, consciousness, emotion, temperature and pain sensation, hunger, satiation, taste and the predisposition to obesity, the role of PET in clinical oncology, the role of ..
  48. Impact of Receptor Polymorphisms on Sensations from Common Oral Irritants
    JOHN EDWARD HAYES; Fiscal Year: 2013
    ..Important covariates include frequency of spicy food intake, personality factors (novelty seeking, and sensation seeking) and underlying differences in the intensity of oral sensations (supertasting)...
  49. Neural Interface and Control Design to Restore Sensation in Amputees
    MATTHEW ANTHONY SCHIEFER; Fiscal Year: 2012
    ..at the same time that the subject's nerve is stimulated with a set of stimulus parameters known to induce a sensation somewhere else...
  50. Effects of aging on primary afferent function
    RATAN BANIK; Fiscal Year: 2009
    ..Under the third specific aim, heat pain, cold sensation, and tactile threshold related behaviors will be evaluated...
  51. Molecular Imaging of Retrograde Nerve Transport
    DAWID NONE SCHELLINGERHOUT; Fiscal Year: 2013
    ..Diagnosing nerve disease leading to loss of sensation in the feet due to diabetes earlier, and monitoring treatments for this neuropathy to see if it is working ..
  52. Molecular mechanisms in controlling development of touch-sensing neurons
    Wenqin Luo; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Touch sensation, which is essential for our daily life, social interactions and sexual behaviors, is mediated by mechanosensory neurons within the trigeminal (TG) and dorsal root ganglion (DRG)...
  53. Force Clamp Systems for Evaluation of Mechanotransduction
    BETH L PRUITT; Fiscal Year: 2013
    ..controlled mechanical stimuli and of animal models amenable to analysis of the mechanobiology of touch sensation. The objective of the proposed research is to bridge this gap by developing new devices for controlled force ..
  54. FETAL CARDIOVASCULAR AND ENDOCRINE REFLEX RESPONSES
    Charles E Wood; Fiscal Year: 2013
    ..and that the degree of inhibition correlates to cellular activity in brain regions and nuclei subserving sensation and integration of the reflex responses;2) to test the hypothesis that BCO, HH, and UCC all increase ..
  55. Identification, Development and Function of Rapidly Adapting Mechanoreceptors
    Wenqin Luo; Fiscal Year: 2013
    Touch sensation, including the perception of form and texture, is essential for our daily lives...
  56. MECHANISM OF NOCICEPTION INDUCED BY INNOCUOUS COLD IN TRIGEMINAL SYSTEM
    Jianguo Gu; Fiscal Year: 2012
    ..One common symptom in many chronic orofacial pain conditions is the severe painful sensation induced by cooling temperatures that would normally produce innocuous or pleasant cooling sensation...
  57. Chemokines, TRP Channels and Cancer Pain
    Durga Prasanna Mohapatra; Fiscal Year: 2013
    ..TRPV1 have been suggested to play a key role in the sensation of inflammatory and arthritic pain, as well as in pain associated with cancers...
  58. Development of the Gustatory Solitary Nucleus
    Robert M Bradley; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Taste sensation, which guides nutritive choices and ingestive behaviors of all vertebrates, is transduced by peripheral ..
  59. Post-Stroke Contributors to Increased Energetic Cost and Decreased Gait Stability
    JESSE CRAIG DEAN; Fiscal Year: 2012
    ..and the ability to sense the mechanical state of the moving body segment using feedback from the periphery (sensation accuracy), both abilities which are commonly reduced after a stroke...
  60. Mechanisms of Neuropathic Pain in Demylenated Nerves
    Fletcher A White; Fiscal Year: 2010
    ..Reported neuropathies include increases in the threshold required for vibration and cold sensation, in addition to neuropathic pain...
  61. Examining the neural circuit for an instinctive olfactory-induced behavior in lar
    Scott T Laughlin; Fiscal Year: 2013
    ..Ultimately, using this behavior as a guide, we will be able to connect the sensation of specific molecular structures with the types of olfactory receptors they bind, the types of olfactory sensory ..
  62. Schwann Cell Control of Chronic Nerve Injury
    Ranjan Gupta; Fiscal Year: 2013
    ..These peripheral neuropathies produce substantial morbidity secondary to symptoms of pain, altered sensation, and muscle atrophy because treatment options are very limited...
  63. Bladder Voiding via Pudendal Nerve Block
    KENNETH GUSTAFSON; Fiscal Year: 2009
    ..can reduce these complications but may result in loss of urinary and fecal continence, sexual function and sensation. Research Design and Methods: This study proposes a new approach utilizing high frequency (HF) electrical ..
  64. CAD-CAM TECHNOLOGY FOR DIABETIC FOOTWEAR
    JOSEPH L LOOMIS; Fiscal Year: 2010
    ..The majority of foot ulcers in diabetic patients are the result of loss of protective sensation (LOPS) secondary to neuropathy that permits unperceived injury...
  65. EMG Biofeedback with AMES
    Paul Cordo; Fiscal Year: 2007
    ..a novel therapeutic regimen and robotic device called "AMES," an acronym for Assisted Movement with Enhanced Sensation. In AMES, the patient assists the motion of the robotic device using biofeedback of voluntary joint torque, ..
  66. AGE, SENSATION AND FALLS--BIOMECHANICS AND PREVENTION
    Ge Wu; Fiscal Year: 1999
    ..the eyes and the effect of somatosensory input by testing subjects with peripheral neuropathy who have decreased sensation in their lower extremities...
  67. GENERAL ANESTHETICS AND CLONED VOLTAGE-GATED CHANNELS
    ANA CORREA; Fiscal Year: 2000
    General anesthesia is a condition in which loss of memory and consciousness is accompanied by loss of pain sensation. Inhalation general anesthetics (GA), fundamental aides in surgical anesthesia, induce both but not without displaying ..
  68. Targeting S1P receptors to prevent hearing loss
    Jerold Chun; Fiscal Year: 2010
    ..hair cells, the primary functional subunits required for the transduction of vibration into the auditory sensation, are subject to irreversible degeneration and consequent loss of hearing acuity...
  69. ANORECTAL MANIFESTATIONS OF FEMALE PELVIC FLOOR DISORDER
    Adil Bharucha; Fiscal Year: 2002
    ..The role of rectal compliance, rectoanal compliance (i.e. marked urgency), and/or diminished recto-anal sensation (e.e...
  70. Hyperbaric O2 Stimulation of Salivary Flow in Radiation -induced Xerostomia
    Michael Martin; Fiscal Year: 2009
    ..and other oral infections, inability to wear dentures due to decreased oral moisture, diminished gustatory sensation, difficulty in speech, and very significantly decreased quality of life...
  71. LCP Nerve Cuff with Telemetry for Prosthetic Sensation
    RONALD RISO; Fiscal Year: 2004
    ..PHASE II work will involve in-vivo tests in animal models followed by evaluation in clinical trials with amputee volunteers and with spinal cord injury and stroke patients. ..
  72. AMES+Brain Stimulation: Treatment for Profound Plegia in Stroke
    Paul Cordo; Fiscal Year: 2010
    ..through the use of a recently developed therapeutic intervention called "AMES" (Assisted Movement with Enhanced Sensation)...
  73. RISK-TAKING, AROUSAL, MARIJUANA AND SEXUAL DECISIONS
    Rick Zimmerman; Fiscal Year: 2001
    ..In addition, risk-taking is associated with individual differences, particularly impulsivity and sensation-seeking...
  74. REFLEX REGULATION OF THE HUMAN BREATHING PATTERN
    JOHN DAUBENSPECK; Fiscal Year: 1999
    ..study is to improve understanding of how information from peripheral mechanoreceptors involved in respiratory sensation and control is used by the central respiratory control processes in normal subjects and in patients with ..
  75. IRRITATION INDUCED PLASTICITY OF MICTURITION PATHWAYS
    MARGARET VIZZARD; Fiscal Year: 2000
    ..The working hypothesis for this research proposal is that one component of IC involves an alteration of visceral sensation/bladder sensory physiology...