satiety response

Summary

Summary: Behavioral response associated with the achieving of gratification.

Top Publications

  1. pmc Gastrointestinal regulation of food intake
    David E Cummings
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Clin Invest 117:13-23. 2007
  2. ncbi Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal
    Patrice D Cani
    Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Universite Catholique de Louvain, Brussels, Belgium
    Am J Clin Nutr 90:1236-43. 2009
  3. ncbi Images of desire: food-craving activation during fMRI
    Marcia Levin Pelchat
    Monell Chemical Senses Center, Philadelphia, PA 19104 3308, USA
    Neuroimage 23:1486-93. 2004
  4. ncbi Critical role for peptide YY in protein-mediated satiation and body-weight regulation
    Rachel L Batterham
    Centre for Diabetes and Endocrinology, Department of Medicine, University College London, WC1E 6JJ, United Kingdom
    Cell Metab 4:223-33. 2006
  5. ncbi The timing of meals
    Jan H Strubbe
    Department of Neuroendocrinology, University of Groningen, Haren, The Netherlands
    Psychol Rev 111:128-41. 2004
  6. pmc Dietary fiber supplements: effects in obesity and metabolic syndrome and relationship to gastrointestinal functions
    Athanasios Papathanasopoulos
    Clinical Enteric Neuroscience Translational and Epidemiological Research, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastroenterology 138:65-72.e1-2. 2010
  7. pmc Does hunger and satiety drive eating anymore? Increasing eating occasions and decreasing time between eating occasions in the United States
    Barry M Popkin
    Carolina Population Center, University of North Carolina, 123 West Franklin Street, Chapel Hill, NC 27516, USA
    Am J Clin Nutr 91:1342-7. 2010
  8. pmc Prebiotic fibres dose-dependently increase satiety hormones and alter Bacteroidetes and Firmicutes in lean and obese JCR:LA-cp rats
    Jill A Parnell
    Department of Physical Education and Recreation Studies, Mount Royal University, 4825 Mount Royal Gate SW, Calgary, AB, Canada
    Br J Nutr 107:601-13. 2012
  9. ncbi Gastric distention activates satiety circuitry in the human brain
    Gene Jack Wang
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 39:1824-31. 2008
  10. pmc The effect of fruit in different forms on energy intake and satiety at a meal
    Julie E Flood-Obbagy
    Department of Nutritional Sciences, The Pennsylvania State University, 226 Henderson Building, University Park, PA 16802, USA
    Appetite 52:416-22. 2009

Detail Information

Publications217 found, 100 shown here

  1. pmc Gastrointestinal regulation of food intake
    David E Cummings
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Clin Invest 117:13-23. 2007
    ..The increasingly nuanced understanding of the mechanisms mediating gut-peptide regulation and action provides promising targets for new strategies to combat obesity and diabetes...
  2. ncbi Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal
    Patrice D Cani
    Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Universite Catholique de Louvain, Brussels, Belgium
    Am J Clin Nutr 90:1236-43. 2009
    ..In rodents, these effects are associated with an increase in plasma gut peptide concentrations, which are involved in appetite regulation and glucose homeostasis...
  3. ncbi Images of desire: food-craving activation during fMRI
    Marcia Levin Pelchat
    Monell Chemical Senses Center, Philadelphia, PA 19104 3308, USA
    Neuroimage 23:1486-93. 2004
    ..Craving-related changes in fMRI signal were identified in the hippocampus, insula, and caudate, three areas reported to be involved in drug craving. Thus, this work supports the common substrate hypothesis for food and drug cravings...
  4. ncbi Critical role for peptide YY in protein-mediated satiation and body-weight regulation
    Rachel L Batterham
    Centre for Diabetes and Endocrinology, Department of Medicine, University College London, WC1E 6JJ, United Kingdom
    Cell Metab 4:223-33. 2006
    ..Our findings suggest that modulating the release of endogenous satiety factors, such as PYY, through alteration of specific diet constituents could provide a rational therapy for obesity...
  5. ncbi The timing of meals
    Jan H Strubbe
    Department of Neuroendocrinology, University of Groningen, Haren, The Netherlands
    Psychol Rev 111:128-41. 2004
    ..The third relates to the size of the preceding meal, such that larger meals cause a longer delay until the onset of the next meal. Superimposed on these 3 are factors related to learning, convenience, and opportunity...
  6. pmc Dietary fiber supplements: effects in obesity and metabolic syndrome and relationship to gastrointestinal functions
    Athanasios Papathanasopoulos
    Clinical Enteric Neuroscience Translational and Epidemiological Research, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastroenterology 138:65-72.e1-2. 2010
    ....
  7. pmc Does hunger and satiety drive eating anymore? Increasing eating occasions and decreasing time between eating occasions in the United States
    Barry M Popkin
    Carolina Population Center, University of North Carolina, 123 West Franklin Street, Chapel Hill, NC 27516, USA
    Am J Clin Nutr 91:1342-7. 2010
    ..The design of dietary, metabolic, and intervention studies should reflect the meal patterning of free-living individuals, but this design has not been systematically reviewed recently...
  8. pmc Prebiotic fibres dose-dependently increase satiety hormones and alter Bacteroidetes and Firmicutes in lean and obese JCR:LA-cp rats
    Jill A Parnell
    Department of Physical Education and Recreation Studies, Mount Royal University, 4825 Mount Royal Gate SW, Calgary, AB, Canada
    Br J Nutr 107:601-13. 2012
    ..The combined effects of prebiotics may have therapeutic potential for obesity...
  9. ncbi Gastric distention activates satiety circuitry in the human brain
    Gene Jack Wang
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 39:1824-31. 2008
    ..These findings provide evidence that the left amygdala and insula process interoceptive signals of fullness produced by gastric distention involved in the controls of food intake...
  10. pmc The effect of fruit in different forms on energy intake and satiety at a meal
    Julie E Flood-Obbagy
    Department of Nutritional Sciences, The Pennsylvania State University, 226 Henderson Building, University Park, PA 16802, USA
    Appetite 52:416-22. 2009
    ..Adding naturally occurring levels of fiber to juice did not enhance satiety. These results suggest that solid fruit affects satiety more than pureed fruit or juice, and that eating fruit at the start of a meal can reduce energy intake...
  11. ncbi The effects of high protein diets on thermogenesis, satiety and weight loss: a critical review
    Thomas L Halton
    Dept of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    J Am Coll Nutr 23:373-85. 2004
    ..Although recent evidence supports potential benefit, rigorous longer-term studies are needed to investigate the effects of high protein diets on weight loss and weight maintenance...
  12. ncbi Salad and satiety: energy density and portion size of a first-course salad affect energy intake at lunch
    Barbara J Rolls
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
    J Am Diet Assoc 104:1570-6. 2004
    ..We tested the effect on meal intake of varying the energy density and portion size of a compulsory first-course salad...
  13. ncbi Effect of television viewing at mealtime on food intake after a glucose preload in boys
    Nick Bellissimo
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 3E2, Canada
    Pediatr Res 61:745-9. 2007
    ..In conclusion, TVV while eating a meal contributes to increased energy intake by delaying normal mealtime satiation and reducing satiety signals from previously consumed foods...
  14. pmc Characterization of the diurnal rhythm of peptide YY and its association with energy balance parameters in normal-weight premenopausal women
    Brenna R Hill
    Women s Health and Exercise Laboratory and the Department of Kinesiology, Pennsylvania State University, University Park, PA 16802, USA
    Am J Physiol Endocrinol Metab 301:E409-15. 2011
    ..Thus, PYY varies in accordance with energy content and RMR, supporting a role for PYY in energy balance modulation...
  15. ncbi Appetite regulation and energy balance
    Charlotte Erlanson-Albertsson
    Department of Experimental Medicine, University of Lund, Lund, Sweden
    Acta Paediatr Suppl 94:40-1. 2005
    ..The palatable food works by weakening the satiety signals and activating the hunger signals. The reward system with endogenous opiates may also be activated...
  16. ncbi Food form and portion size affect postprandial appetite sensations and hormonal responses in healthy, nonobese, older adults
    Heather J Leidy
    Department of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, Kansas, USA
    Obesity (Silver Spring) 18:293-9. 2010
    ..larger portions suggest that appetite control is influenced by food form and portion size in older adults. These findings may enhance the development of appropriate dietary strategies that help to regulate energy balance...
  17. pmc Operant self-stimulation of dopamine neurons in the substantia nigra
    Mark A Rossi
    Department of Psychology and Neuroscience, Duke University, Durham, North Carolina, United States of America
    PLoS ONE 8:e65799. 2013
    ..Together these results suggest that selective activation of SNC DA neurons can be sufficient for acquisition and maintenance of a new instrumental action...
  18. ncbi Signals that influence food intake and body weight
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237, United States
    Physiol Behav 86:709-16. 2005
    ..This review discusses hormonal and related satiety signals generated as food is being consumed, and upon adiposity signals related to the amount of fat stored in the body, that influence energy intake and ultimately body weight...
  19. pmc Cholinergic regulation of ghrelin and peptide YY release may be impaired in obesity
    Christina Maier
    Clinical Division of Endocrinology and Metabolism, Department ofMedicine III, Medical University of Vienna, Vienna, Austria
    Diabetes 57:2332-40. 2008
    ..The aim of this study was to examine the effects of the cholinergic antagonist atropine on ghrelin, PYY, glucose, and insulin under basal conditions and after meal ingestion in lean and obese subjects...
  20. ncbi Measuring 'expected satiety' in a range of common foods using a method of constant stimuli
    Jeffrey M Brunstrom
    Department of Experimental Psychology, University of Bristol, 12a Priory Road, Bristol, England, United Kingdom
    Appetite 51:604-14. 2008
    ..Future use of this methodology is discussed, both in relation to our understanding of portion-size decisions and its application more generally...
  21. ncbi Sweetness, satiation, and satiety
    France Bellisle
    Centre de Recherche en Nutrition Humaine d Ile de France, Universite Paris, Bobigny, France
    J Nutr 142:1149S-54S. 2012
    ..The brain mechanisms of food reward (in terms of "liking" and "wanting") are also addressed. Finally, we highlight the importance of reward homeostasis, which can help prevent eating in the absence of hunger, for the control of intake...
  22. ncbi Loss of acute satiety response to cholecystokinin in pregnant rats
    S R Ladyman
    Centre for Neuroendocrinology and Department of Anatomy, University of Otago, Dunedin, New Zealand
    J Neuroendocrinol 23:1091-8. 2011
    ..These results indicate that pregnant rats are no longer responsive to the actions of CCK on short-term food intake and that CCK action in the NTS is reduced during pregnancy...
  23. ncbi Impact of acute sleep restriction on cortisol and leptin levels in young women
    Antonina Omisade
    Department of Psychology, Dalhousie University, Halifax, NS, Canada
    Physiol Behav 99:651-6. 2010
    ..04). Hunger and craving scores did not differ significantly between days. A single night of restricted sleep affected cortisol rhythms and morning leptin levels in young women...
  24. ncbi Dietary variety, energy regulation, and obesity
    H A Raynor
    Department of Psychology, University at Buffalo, New York 14214, USA
    Psychol Bull 127:325-41. 2001
    ....
  25. ncbi Augmented reinforcer value and accelerated habit formation after repeated amphetamine treatment
    R E Nordquist
    Department of Anatomy and Neurosciences, Research Institute of Neurosciences, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 17:532-40. 2007
    ..These data show that both habit formation and motivational value of reinforcers are augmented in amphetamine-sensitized rats, and suggest that the task demands determine which behavioral alteration is most prominently expressed...
  26. ncbi Norepinephrine and the control of food intake
    P J Wellman
    Department of Psychology, Texas A and M University, College Station, Texas 77843 4235, USA
    Nutrition 16:837-42. 2000
    ..The present review considers potential interactions of NE with substances such as leptin and neuropeptide Y that alter eating...
  27. ncbi Fat as a risk factor for overconsumption: satiation, satiety, and patterns of eating
    J E Blundell
    Department of Psychology, University of Leeds, United Kingdom
    J Am Diet Assoc 97:S63-9. 1997
    ..A first stage in a health program should be to prevent passive overconsumption...
  28. pmc The glucose-dependent insulinotropic polypeptide and glucose-stimulated insulin response to exercise training and diet in obesity
    Karen R Kelly
    Department of Pathobiology, Lerner Research Institute, Cleveland, OH 44195, USA
    Am J Physiol Endocrinol Metab 296:E1269-74. 2009
    ....
  29. ncbi Attenuated peptide YY release in obese subjects is associated with reduced satiety
    C W le Roux
    Department of Metabolic Medicine, 6th Floor Commonwealth Building, Hammersmith Hospital, Imperial College London, London W12 0NN, United Kingdom
    Endocrinology 147:3-8. 2006
    ..We conclude that obese subjects have a PYY deficiency that would reduce satiety and could thus reinforce their obesity...
  30. ncbi Recall of recent lunch and its effect on subsequent snack intake
    Suzanne Higgs
    School of Psychology, University of Birmingham, England, UK
    Physiol Behav 94:454-62. 2008
    ..It is concluded that the inhibitory effect of recalling foods eaten at lunch on subsequent snack intake is a robust phenomenon that is related to memory of that lunch and is moderated by tendency toward dietary disinhibition...
  31. ncbi Hunger selectively modulates corticolimbic activation to food stimuli in humans
    K S LaBar
    Department of Psychology Experimental, Duke University, Durham, North Carolina 27708 0999, USA
    Behav Neurosci 115:493-500. 2001
    ..These results support the hypothesis that the amygdala and associated inferotemporal regions are involved in the integration of subjective interoceptive states with relevant sensory cues processed along the ventral visual stream...
  32. ncbi Energy density of foods: effects on energy intake
    J Stubbs
    The Rowett Research Institute, Bucksburn, Aberdeen, UK
    Crit Rev Food Sci Nutr 40:481-515. 2000
    ..The available evidence suggests that we should be evolving more complex, multifactor models to account for the observations that both macronutrients and ED affect EI rather than substituting one simplistic model with another...
  33. ncbi Beverage viscosity is inversely related to postprandial hunger in humans
    R D Mattes
    Department of Foods and Nutrition, Purdue University, Room 212, 1264 Stone Hall, West Lafayette, IN 47907 1264, USA
    Physiol Behav 74:551-7. 2001
    ..No significant differences were noted in the size or time to first meal or 24 h energy intake. These data indicate viscosity exerts an independent inverse effect on hunger in humans...
  34. ncbi The cholecystokinin type A receptor g.179A>G polymorphism affects feeding rate
    R D Houston
    Division of Genetics and Genomics, Roslin Institute Edinburgh, Roslin, Midlothian EH25 9PS, UK
    Anim Genet 39:187-8. 2008
    ..The data indicate that the daily feed intake increasing effect of the DQ496228:g.179G allele is mediated through a faster rate of feed intake, without evidence for an effect on other feeding behaviour traits...
  35. ncbi Sucrose sham feeding on a binge schedule releases accumbens dopamine repeatedly and eliminates the acetylcholine satiety response
    N M Avena
    Department of Psychology, Princeton University, Princeton, NJ 08540, USA
    Neuroscience 139:813-20. 2006
    ....
  36. ncbi Development and preliminary validation of a silhouette satiety scale for children
    Myles S Faith
    Obesity Research Center, Columbia University College of Physicians and Surgeons, 1090 Amsterdam Avenue 14A, New York, NY 10025, USA
    Physiol Behav 76:173-8. 2002
    ..Young children may be more capable of quantitatively reporting feelings of satiety than is commonly believed, if appropriate experimental materials are used...
  37. ncbi Effect of human body weight changes on circulating levels of peptide YY and peptide YY3-36
    P T Pfluger
    Department of Psychiatry, University of Cincinnati, Office E 217, Genome Research Institute, 2170 East Galbraith Road, Cincinnati, Ohio 45237, USA
    J Clin Endocrinol Metab 92:583-8. 2007
    ..Although the pharmacological value of PYY is controversial, further study of the secretion of the precursor PYY(1-36) and the pharmacologically active PYY(3-36) is indicated to determine the potential role in energy balance regulation...
  38. ncbi Measuring meals: structure of prandial food and water intake of rats
    Eric P Zorrilla
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1450-67. 2005
    ..Thus log-survivorship analysis is not appropriate for identifying meal breakpoints, and the consideration of drinking in meal definitions can provide a better estimate of meal structure...
  39. ncbi Short-term sleep loss decreases physical activity under free-living conditions but does not increase food intake under time-deprived laboratory conditions in healthy men
    Sebastian M Schmid
    Departments of Internal Medicine I, the University of Luebeck, Luebeck, Germany
    Am J Clin Nutr 90:1476-82. 2009
    ..Short sleep duration is correlated with an increased risk of developing obesity and cardiovascular disease, but the mechanisms behind this relation are largely unknown...
  40. ncbi Gastrointestinal satiety signals I. An overview of gastrointestinal signals that influence food intake
    Stephen C Woods
    Dept of Psychiatry, Univ of Cincinnati, Cincinnati, OH 45267, USA
    Am J Physiol Gastrointest Liver Physiol 286:G7-13. 2004
    ..Most factors that influence how much food is eaten during individual meals act by changing the sensitivity to satiety signals. This includes adiposity signals as well as habits and learning, the social situation, and stressors...
  41. ncbi Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size
    James E Blevins
    VA Puget Sound Health Care System, Research Service 151 1660 S Columbian Wy, Seattle, WA 98108, USA
    Am J Physiol Regul Integr Comp Physiol 287:R87-96. 2004
    ....
  42. ncbi Water incorporated into a food but not served with a food decreases energy intake in lean women
    B J Rolls
    Nutrition Department, The Pennsylvania State University, University Park 16802 6501, USA
    Am J Clin Nutr 70:448-55. 1999
    ..Previous research showed that decreasing the energy density (kJ/g) of foods by adding water to them can lead to reductions in energy intake. Few studies have examined how water consumed as a beverage affects food intake...
  43. ncbi Differential effects of gastric bypass and banding on circulating gut hormone and leptin levels
    Judith Korner
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Obesity (Silver Spring) 14:1553-61. 2006
    ..To quantify plasma concentrations of hormones that regulate energy homeostasis in order to establish possible mechanisms for greater weight loss after Roux-en-Y gastric bypass (RYGBP) compared with gastric banding (BND)...
  44. ncbi Olfactory sensory-specific satiety in humans
    E T Rolls
    Department of Experimental Psychology, University of Oxford, UK
    Physiol Behav 61:461-73. 1997
    ..The implications for the control of food intake, and the way in which the brain computes sensory-specific satiety, are considered...
  45. ncbi Interactions between gastric emptying and satiety, with special reference to glucagon-like peptide-1
    P M Hellstrom
    Department of Internal Medicine, Unit of Gastroenterology Karolinska Hospital, Karolinska Institutet, SE 171 76, Stockholm, Sweden
    Physiol Behav 74:735-41. 2001
    ..To conclude, after food intake, gut peptides may act in concert as neurohormonal satiety signals acting directly in the brain or indirectly via the vagus nerve, as well as through gastric sensory mechanisms to limit food intake...
  46. ncbi Effect of meal viscosity and nutrients on satiety, intragastric dilution, and emptying assessed by MRI
    L Marciani
    Magnetic Resonance Centre, School of Physics and Astronomy, Nottingham NG7 2RD, United Kingdom
    Am J Physiol Gastrointest Liver Physiol 280:G1227-33. 2001
    ..96). Fullness was higher for high- compared with low-viscosity meals (P < 0.02), and with the nutrient meals this was associated with greater antral volumes (P < 0.05)...
  47. pmc Effects of glucagon-like peptide-1(7-36)amide on motility and sensation of the proximal stomach in humans
    J Schirra
    Department of Gastroenterology and Endocrinology, Philipps University, Marburg, Germany
    Gut 50:341-8. 2002
    ..Glucagon-like peptide-1(7-36)amide (GLP-1) retards gastric emptying, reduces food intake, and inhibits antroduodenal and stimulates pyloric motility...
  48. ncbi The significance of protein in food intake and body weight regulation
    Margriet S Westerterp-Plantenga
    Department of Human Biology, PO Box 616, 6200 MD Maastricht, The Netherlands
    Curr Opin Clin Nutr Metab Care 6:635-8. 2003
    ..To highlight the underexposed but important role of protein in food intake and body weight regulation...
  49. ncbi Vinegar supplementation lowers glucose and insulin responses and increases satiety after a bread meal in healthy subjects
    E Ostman
    Applied Nutrition and Food Chemistry, Department of Food Technology, Engineering and Nutrition, Lund University, Lund, Sweden
    Eur J Clin Nutr 59:983-8. 2005
    ..To investigate the potential of acetic acid supplementation as a means of lowering the glycaemic index (GI) of a bread meal, and to evaluate the possible dose-response effect on postprandial glycaemia, insulinaemia and satiety...
  50. ncbi Functional dyspepsia symptoms, gastric emptying and satiety provocative test: analysis of relationships
    R Cuomo
    Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Napoli Federico II, Italy
    Scand J Gastroenterol 36:1030-6. 2001
    ....
  51. ncbi Gut hormones and appetite control
    A M Wren
    Department of Metabolic Medicine, Imperial College London, London, England
    Gastroenterology 132:2116-30. 2007
    ..Gut hormone-based therapies may thus provide an effective and well-tolerated treatment for obesity...
  52. ncbi Increasing the volume of a food by incorporating air affects satiety in men
    B J Rolls
    Nutrition Department, The Pennsylvania State University, University Park 16802 6501, USA
    Am J Clin Nutr 72:361-8. 2000
    ..However, the addition of water affects not only the volume but also the energy density (kJ/g) of foods. No studies have examined the effect of volume independent of energy density on intake...
  53. pmc The oxytocin/vasopressin receptor antagonist atosiban delays the gastric emptying of a semisolid meal compared to saline in human
    Bodil Ohlsson
    Department of Clinical Sciences, Entrance 35, S 205 02 Malmo, Sweden
    BMC Gastroenterol 6:11. 2006
    ..Further, mRNA for oxytocin and its receptor have been found throughout the gastrointestinal (GI) tract. The aim of this study was therefore to examine whether oxytocin, or the receptor antagonist atosiban, influence the gastric emptying...
  54. ncbi Proteins and satiety: implications for weight management
    Stijn Soenen
    Department of Human Biology, NUTRIM, Maastricht University, Maastricht, The Netherlands
    Curr Opin Clin Nutr Metab Care 11:747-51. 2008
    ..To highlight the satiating background and effects of proteins and their implications for weight management...
  55. ncbi Physical state of meal affects gastric emptying, cholecystokinin release and satiety
    A Santangelo
    Department of Food Science and Technology, University of Milan, Italy
    Br J Nutr 80:521-7. 1998
    ..Moreover, the relationship observed between antral area and fullness sensation confirms that antral distension plays a part in the regulation of eating behaviour...
  56. ncbi Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system
    Wei Fan
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Nat Neurosci 7:335-6. 2004
    ....
  57. ncbi The role of oxyntomodulin and peptide tyrosine-tyrosine (PYY) in appetite control
    Katie Wynne
    Department of Metabolic Medicine, Imperial College London, and Hammersmith Hospital, UK
    Nat Clin Pract Endocrinol Metab 2:612-20. 2006
    ..This research suggests that modulation of these gut hormones could prove to be effective long-term therapies in the quest to combat the obesity epidemic...
  58. ncbi Appetite sensations and satiety quotient: predictors of energy intake and weight loss
    Vicky Drapeau
    Division of Kinesiology, Laval University and Laval Hospital Research Center, Ste Foy, Quebec, Canada G1K 7P4
    Appetite 48:159-66. 2007
    ..The aim of this study was to further evaluate the validity and clinical meaningfulness of appetite sensations to predict overall energy intake as well as body weight loss...
  59. pmc Forebrain melanocortin signaling enhances the hindbrain satiety response to CCK-8
    James E Blevins
    VA Puget Sound Health Care System, Mail stop S 151, 1660 South Columbian Way, Seattle, WA 98108, USA
    Am J Physiol Regul Integr Comp Physiol 296:R476-84. 2009
    ..melanocortin signaling in the hypothalamic paraventricular nucleus (PVN) participates in regulating this CCK satiety response, we administered the MC3/MC4R antagonist, SHU9119, into the PVN of rats before ip CCK-8 administration...
  60. ncbi Protein intake and energy balance
    Margriet S Westerterp-Plantenga
    Department of Human Biology, NUTRIM, and Wageningen Centre of Food Sciences, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Regul Pept 149:67-9. 2008
    ..Therefore 'high protein negative energy balance diets' aim to keep the grams of proteins ingested at the same level as consumed at energy balance, despite lower energy intakes...
  61. ncbi Appetite sensations as a marker of overall intake
    Vicky Drapeau
    Division of Kinesiology, Laval University, Ste Foy, Quebec, Canada, G1K 7P4
    Br J Nutr 93:273-80. 2005
    ..Thus, assessment of appetite sensation such as fullness in response to a fixed load may be useful to evaluate individual overall energy intake...
  62. ncbi Effect of a protein preload on food intake and satiety feelings in response to duodenal fat perfusions in healthy male subjects
    Sibylle Oesch
    Division of Gastroenterology, University Hospital, CH 4031 Basel, Switzerland
    Am J Physiol Regul Integr Comp Physiol 289:R1042-7. 2005
    ..Much more information is necessary to understand the basic physiological mechanisms that control food intake and satiety...
  63. ncbi Associations between postprandial insulin and blood glucose responses, appetite sensations and energy intake in normal weight and overweight individuals: a meta-analysis of test meal studies
    Anne Flint
    Novo Nordisk A S, Smørmosevej 2, Bagsvaerd, Denmark
    Br J Nutr 98:17-25. 2007
    ..We conclude that the postprandial insulin response may be an important satiety signal, and that central nervous system insulin resistance in overweight might explain the blunted effect on appetite...
  64. pmc Liquid and solid meal replacement products differentially affect postprandial appetite and food intake in older adults
    April J Stull
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    J Am Diet Assoc 108:1226-30. 2008
    ....
  65. ncbi Postprandial response of plasma ghrelin levels to various test meals in relation to food intake, plasma insulin, and glucose
    Johannes Erdmann
    Department of Internal Medicine, Else Kröner Fresenius Center of Nutritional Medicine, Technical University of Munich, D 81675 Munich, Germany
    J Clin Endocrinol Metab 89:3048-54. 2004
    ....
  66. ncbi Effect of bite size and oral processing time of a semisolid food on satiation
    Nicolien Zijlstra
    Top Institute Food and Nutrition, Wageningen, Netherlands
    Am J Clin Nutr 90:269-75. 2009
    ..In previous studies we showed a clear effect of viscosity on ad libitum food intake and found indications that eating rate, bite size, and oral processing time (OPT) could play a role...
  67. ncbi Effect of viscosity on learned satiation
    M Mars
    Top Institute Food and Nutrition, PO Box 557, NL 6700 AN, Wageningen, The Netherlands
    Physiol Behav 98:60-6. 2009
    ..04; p=0.31); after 10 exposures intake difference between the LED and HED yogurts was only 1.5+/-15 g. These results suggest that a higher viscosity facilitates learned satiation...
  68. ncbi Stimulus-outcome interactions during instrumental discrimination learning by rats and humans
    S de Wit
    Department of Experimental PsychologyUniversity of Cambridge, Cambridge, England
    J Exp Psychol Anim Behav Process 33:1-11. 2007
    ..Moreover, responding was resistant to outcome devaluation following incongruent, but not congruent, training, suggesting that both humans and rats adopted a stimulus-response strategy to resolve the incongruent discrimination...
  69. ncbi In vivo imaging of intragastric gelation and its effect on satiety in humans
    Caroline L Hoad
    Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, Nottingham, UK
    J Nutr 134:2293-300. 2004
    ..Agents that gel on contact with acid may be useful additions to weight-reducing diets. We hypothesize that this effect is due to distension in the gastric antrum and/or altered transport of nutrients to the small intestine in the lumps...
  70. ncbi Prolongation of intermeal interval by gastrin-releasing peptide depends upon time of delivery
    P A Rushing
    Department of Psychiatry, Cornell University Medical College, New York Hospital Cornell Medical Center, White Plains 10605, USA
    Peptides 19:1439-42. 1998
    ..These results are consistent with the hypothesis that endogenous GRP acts in conjunction with events occurring shortly after meal termination to extend the duration of the IMI...
  71. ncbi Filling yet fattening: stereotypical beliefs about the weight gain potential and satiation of foods
    Michael E Oakes
    Department of Psychology, University of Scranton, Scranton, PA 18510 4596, USA
    Appetite 46:224-33. 2006
    ..Apparently, food names have acquired reputation for promoting obesity and (to a lesser extent) hunger satisfaction that are not based on their nutrient profiles...
  72. ncbi Less activation of the left dorsolateral prefrontal cortex in response to a meal: a feature of obesity
    Duc Son N T Le
    Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Phoenix, AZ 85016, USA
    Am J Clin Nutr 84:725-31. 2006
    ..The subjects received a meal proportional to their body size; therefore, the meal volume was different for each person...
  73. ncbi Tasting fat: cephalic phase hormonal responses and food intake in restrained and unrestrained eaters
    Susan R Crystal
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, United States
    Physiol Behav 89:213-20. 2006
    ..05). In conclusion, the sensory experience of tasting fat increases food intake in restrained eaters and increases vagal efferent activity compared to a non-fat food in both populations...
  74. ncbi Effect of gastric distension prior to eating on food intake and feelings of satiety in humans
    Sibylle Oesch
    Clinical Research Center, Department of Research, University Hospital, CH 4031 Basel, Switzerland
    Physiol Behav 87:903-10. 2006
    ..Cholecystokinin (CCK) and peptide YY (PYY) were not altered by gastric distension. Transient pure mechanical distension of the fundus or the antrum prior to a meal does not trigger satiation...
  75. ncbi Bolus tube feeding suppresses food intake and circulating ghrelin concentrations in healthy subjects in a short-term placebo-controlled trial
    Rebecca J Stratton
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, United Kingdom
    Am J Clin Nutr 88:77-83. 2008
    ..Previous investigations suggest continuous tube feeding (TF) schedules do not suppress appetite and food intake, but bolus TF has been little studied...
  76. ncbi Higher satiety ratings following yogurt consumption relative to fruit drink or dairy fruit drink
    Ami Tsuchiya
    Center for Public Health Nutrition and Nutritional Sciences Program, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
    J Am Diet Assoc 106:550-7. 2006
    ..To compare the satiating power of semisolid and liquid yogurts with fruit beverages and dairy fruit drinks...
  77. ncbi On the road to obesity: Television viewing increases intake of high-density foods
    Elliott M Blass
    Department of Psychology and Program in Neuroscience and Behavior, University of Massachusetts, Amherst, MA 01003, USA
    Physiol Behav 88:597-604. 2006
    ..Thus, watching television increases the amount eaten of high-density, palatable, familiar foods and may constitute one vector contributing to the current obesity crisis...
  78. ncbi Energy density and macronutrient composition determine flavor preference conditioned by intragastric infusions of mixed diets
    Karen Ackroff
    Department of Psychology, Brooklyn College and The Graduate Center, City University of New York, Brooklyn, NY 11210, USA
    Physiol Behav 89:250-60. 2006
    ..The differential satiating effects of fat and carbohydrate may contribute to these density-dependent preferences...
  79. ncbi The effect of increased beverage portion size on energy intake at a meal
    Julie E Flood
    Department of Nutritional Sciences, The Pennsylvania State University, 226 Henderson Building, University Park, PA 16802 6501, USA
    J Am Diet Assoc 106:1984-90; discussion 1990-1. 2006
    ..This study examined the impact of increasing beverage portion size on beverage and food intake...
  80. ncbi Meal-related changes in ghrelin, peptide YY, and appetite in normal weight and overweight children
    Jefferson P Lomenick
    Department of Pediatrics, Division of Endocrinology, University of Kentucky, Lexington, KY, USA
    Obesity (Silver Spring) 16:547-52. 2008
    ..Our objectives were to characterize the patterns of secretion of these hormones in response to feeding in school-age children and determine whether there were differences between normal weight (NW) and overweight (OW) subjects...
  81. ncbi Whey proteins in the regulation of food intake and satiety
    Bohdan L Luhovyy
    Department of Nutritional Sciences, University of Toronto, Rm 329, Fitzgerald Building, 150 College St, Toronto, Ontario, Canada
    J Am Coll Nutr 26:704S-12S. 2007
    ..The effects described have been observed in short-term experiments and when whey is consumed in much higher amounts...
  82. ncbi Neuroendocrine control of food intake
    Elena Valassi
    Chair of Endocrinology, University of Milan, Ospedale San Luca IRCCS, Istituto Auxologico Italiano, Via Spagnoletto 3, 20149 Milan, Italy
    Nutr Metab Cardiovasc Dis 18:158-68. 2008
    ..In conclusion, the present work reviews the most recent insights into the complex and redundant molecular mechanisms regulating food intake, focusing on the most encouraging perspectives for the treatment of obesity...
  83. ncbi Acute effects on metabolism and appetite profile of one meal difference in the lower range of meal frequency
    Astrid J Smeets
    Department of Human Biology, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Br J Nutr 99:1316-21. 2008
    ..In healthy, normal-weight women, decreasing the inter-meal interval sustains satiety, particularly during the day, and sustains fat oxidation, particularly during the night...
  84. ncbi The role of peptide YY in integrative gut physiology and potential role in obesity
    April B M Grudell
    Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Curr Opin Endocrinol Diabetes Obes 14:52-7. 2007
    ..Peptide YY (PYY) - one of the major anorexigenic (satiation-causing) gastrointestinal peptides - when administered peripherally, leads to decreased food intake and hunger scores...
  85. ncbi [The regulation of body mass and its relation to the development of obesity]
    Attila Juhasz
    Sopron MJV Erzsébet Kórház, a DE OEC Oktató Kórháza Belgyógyászat Sopron Gyori
    Orv Hetil 148:1827-36. 2007
    ....
  86. pmc Less activation in the left dorsolateral prefrontal cortex in the reanalysis of the response to a meal in obese than in lean women and its association with successful weight loss
    Duc Son Nt Le
    Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Phoenix, AZ 85016, USA
    Am J Clin Nutr 86:573-9. 2007
    ....
  87. ncbi Test meal intake in obese binge eaters in relation to impulsivity and compulsivity
    Kochavi Galanti
    Ferkauf Graduate School of Psychology and Albert Einstein College of Medicine, Yeshiva University, Bronx, New York, USA
    Int J Eat Disord 40:727-32. 2007
    ..Studies have linked increased impulsivity and compulsivity with bulimia nervosa (BN). Less is known about this relationship in binge eating disorder (BED)...
  88. pmc Soup preloads in a variety of forms reduce meal energy intake
    Julie E Flood
    The Pennsylvania State University, 226 Henderson Building, University Park, PA 16802, USA
    Appetite 49:626-34. 2007
    ..The type of soup had no significant effect on test meal intake or total meal energy intake. Consuming a preload of low-energy-dense soup, in a variety of forms, is one strategy for moderating energy intake in adults...
  89. ncbi Effect of subcutaneous injections of PYY1-36 and PYY3-36 on appetite, ad libitum energy intake, and plasma free fatty acid concentration in obese males
    Birgitte Sloth
    Dept of Human Nutrition, Centre for Advanced Food Studies, Faculty of Life Sciences, Univ of Copenhagen, 30 Rolighedsvej, DK 1958 Frederiksberg, Denmark
    Am J Physiol Endocrinol Metab 293:E604-9. 2007
    ..PYY(1-36) is unlikely to be important in regulating energy intake. The PYY(3-36) administrations caused a non-dose-dependent mobilization of FFA, likely through a direct effect...
  90. pmc Effects of solid versus liquid meal-replacement products of similar energy content on hunger, satiety, and appetite-regulating hormones in older adults
    S M Tieken
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Horm Metab Res 39:389-94. 2007
    ..To examine whether solid versus liquid meal-replacement products differentially affect appetite and appetite-regulating hormones in older adults...
  91. ncbi Altering portion sizes and eating rate to attenuate gorging during a fast food meal: effects on energy intake
    Cara B Ebbeling
    Division of Endocrinology, Department of Medicine, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Pediatrics 119:869-75. 2007
    ..Eating large amounts of food at a rapid rate, defined as gorging, may contribute to excess energy intake. We aimed to evaluate whether altering portion sizes and eating rate could decrease energy intake during an extra-large fast food meal...
  92. ncbi Understanding the mechanisms of food intake and obesity
    E T Rolls
    Department of Experimental Psychology, University of Oxford, Oxford, UK
    Obes Rev 8:67-72. 2007
  93. ncbi Effects of a combination fiber system on appetite and energy intake in overweight humans
    Richard D Mattes
    Department of Foods and Nutrition, Purdue University, 700 W State Street, W Lafayette, IN 47907 2059, United States
    Physiol Behav 90:705-11. 2007
    ....
  94. ncbi [Pharmacotherapy of obesity]
    Volker Schusdziarra
    Else Kröner Fresenius Zentrum für Ernährungsmedizin Kilinikum rechts der Isar, TU Munchen
    Pharm Unserer Zeit 35:500-4. 2006
  95. ncbi Psychobiological effects observed in obese men experiencing body weight loss plateau
    Jean Philippe Chaput
    Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Sainte Foy, Quebec, Canada
    Depress Anxiety 24:518-21. 2007
    ....
  96. ncbi Gastrointestinal regulation of food intake: general aspects and focus on anandamide and oleoylethanolamide
    R Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    J Neuroendocrinol 20:39-46. 2008
    ..Additionally, these acylethanolamides, whose gastric levels change in response to diet-induced obesity, alter gastrointestinal motility, which might contribute to their effect on food intake and nutrient absorption...
  97. ncbi Volume and variety: relative effects on food intake
    G N M Norton
    School of Psychology, University of Liverpool, Liverpool L69 7ZA, UK
    Physiol Behav 87:714-22. 2006
    ..Clearly volume effects on intake rely both on amount consumed and energy density. As predicted, variety stimulated food intake and this occurred across volume conditions...
  98. ncbi The appetite-suppressant effect of nicotine is enhanced by caffeine
    A Jessen
    Research Department of Human Nutrition, Centre for Advanced Food Studies, The Royal Veterinary and Agricultural University, Denmark
    Diabetes Obes Metab 7:327-33. 2005
    ..To test whether the anorectic effect of nicotine may be amplified by caffeine...
  99. ncbi Microanalysis of eating behavior of three leptin deficient adults treated with leptin therapy
    Donald A Williamson
    Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Appetite 45:75-80. 2005
    ..These results are discussed in the context of the scientific literature pertaining to leptin and its effects on appetite and obesity...
  100. ncbi Total subdiaphragmatic vagotomy does not suppress high protein diet-induced food intake depression in rats
    Diane L'Heureux-Bouron
    Unité INRA 914 de Physiologie de la Nutrition et du Comportement Alimentaire, Institut National Agronomique Paris Grignon, F75231 Paris Cedex 05, France
    J Nutr 133:2639-42. 2003
    ..In contrast, a defect in this visceral regulating system could reinforce the metabolic-associated food intake depression signal...
  101. ncbi Dronabinol and marijuana in HIV(+) marijuana smokers: acute effects on caloric intake and mood
    Margaret Haney
    New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, 1051 Riverside Dr, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 181:170-8. 2005
    ..No studies to date have directly compared the tolerability and efficacy of smoked marijuana and oral dronabinol in HIV(+) marijuana smokers...

Research Grants62

  1. Satiety signaling in Caenorhabditis elegans
    Leon Avery; Fiscal Year: 2013
    ..ASI sensory neuron activity signals nutritional well-being and provokes a satiety response. 2...
  2. Role of Oxytocin Signaling in the Pathogenesis of Diet-Induced Obesity
    JAMES ERNEST BLEVINS; Fiscal Year: 2013
    ..Defective activation of CCK-sensing neurons in the NTS and an impaired satiety response to CCK are predicted to result in enhanced susceptibility to DIO...
  3. Brain integration of adiposity and satiety signals in the control of food intake
    Diana Williams; Fiscal Year: 2009
    ..Next, we will investigate whether leptin reduces food intake and enhances the satiety response to gastrointestinal nutrients in part by modulating rats'sensitivity to endogenously released GLP-1 or ..
  4. Brain integration of adiposity and satiety signals in the control of food intake
    Diana L Williams; Fiscal Year: 2011
    ..Next, we will Investigate whether leptin reduces food Intake and enhances the satiety response to gastrointestinal nutrients in part by modulating rats'sensitivity to endogenously released GLP-1 or ..
  5. UPPER GI TRACT MEDIATION OF THE SATIETY EFFECT OF FATS
    Danielle Greenberg; Fiscal Year: 1992
    ..stimuli; and (3) to examine the neural, endocrine or neuroendocrine mechanisms involved in mediating this satiety response in Sprague Dawley rats...
  6. Neural Mechanisms of Overeating in Prader-Willi Syndrome
    Anastasia Dimitropoulos; Fiscal Year: 2009
    ..The specific focus of this project will be to identify if overeating in PWS is caused not only by abnormal satiety response but also by abnormally heightened responses to rewarding food during hunger and after attempted satiation...
  7. PYY3-36: a gut secreted peptide regulating satiety
    LLIA HALATCHEV; Fiscal Year: 2005
    ..to PYY1-36 and also elucidate the physiological role of PYY3-36 as a peripheral feedback signal of the satiety response. Finally, we are interested in determining whether PYY3-36 is acting as a short or long-term peripheral ..
  8. FACTORS AFFECTING CALORIC REGULATION IN HUMAN FEEDING
    Barbara Rolls; Fiscal Year: 2007
    ..The experiments carefully vary fat content while keeping the energy content constant or vice versa, all while maintaining constant palatability. ..
  9. Food Rheology and Feeding in Lean and Obese Humans
    Richard Mattes; Fiscal Year: 2007
    ..abstract_text> ..
  10. HEDONICS AND DIETARY INTAKE OF FAT
    Richard Mattes; Fiscal Year: 2008
    ..This will be explored through stable isotope tracer studies for Aim 3. The proposed work will hold important public health, clinical, commercial and basic biological implications. [unreadable] [unreadable]..
  11. CEPHALIC RESPONSES AND MEAL FEEDING
    Stephen Woods; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  12. OVARIAN HORMONAL CONTROL OF MEAL SIZE
    NORCROSS GEARY; Fiscal Year: 2008
    ..8) Determine the tonic and phasic effects of estradiol on glutamate synaptogenesis in the brainstem by using immunocytochemical detection of synaptic proteins. [unreadable] [unreadable]..
  13. Society for the Study of Ingestive Behavior Annual Meet
    Timothy Moran; Fiscal Year: 2003
    ..abstract_text> ..
  14. Low Carbohydrate Diets: Feeding and Endocrine Signaling
    Timothy Moran; Fiscal Year: 2006
    ..abstract_text> ..
  15. CONTROL OF ALCOHOL INTAKE BY BRAIN-GUT PEPTIDES
    NORCROSS GEARY; Fiscal Year: 2003
    ..The work will be closely coordinated, and we expect this cooperative effort to be very productive. ..
  16. Metabolic and Epigenetic Effects of Maternal High Fat Diet in Obesity Prone Rats
    Timothy H Moran; Fiscal Year: 2010
    ..The results of these experiments will enhance our understanding of the etiology of obesity and metabolic disease ultimately allowing the development of rational clinical interventions for such conditions. ..
  17. ALCOHOL APPETITE--A NUTRIENT CONDITIONING ANALYSIS
    Karen Ackroff; Fiscal Year: 2001
    ..It will advance our basic knowledge of the psychobiology of alcohol appetite and may provide practical benefits for controlling alcohol consumption in humans. ..
  18. DIETARY OBESITY
    George Bray; Fiscal Year: 2007
    ..We now propose these well founded, important and exciting studies which will provide critical new insights into anatomical, physiological and molecular mechanisms by which high levels of dietary fat induce obesity. ..
  19. Programmed adiposity: genetic in utero and postnatal determinants
    Eric Zorrilla; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  20. NEURAL AND GI SUBSTRATES IN BOMBESIN SATIETY
    ELLEN LADENHEIM; Fiscal Year: 2006
    ..Such an understanding will significantly enhance our understanding of the mechanisms underlying overall energy regulation and may lead to novel treatments for obesity or eating disorders ..
  21. Neuropharmacology of Learned Food Preferences
    Anthony Sclafani; Fiscal Year: 2009
    ..It will advance our understanding of the basic mechanisms involved in the development of food preferences and may provide insights into the clinical treatment of overeating and obesity. ..
  22. Urocortins Brain CRF2 Receptors and Energy Balance
    Eric P Zorrilla; Fiscal Year: 2010
    ....
  23. CHANGES IN REINFORCER VALUE AND REINFORCER RELATIVITY
    FRANCES MCSWEENEY; Fiscal Year: 2002
    ..Because operant principles are often used to understand and to treat health-related problems (e.g., drug taking, obesity), this research may have many implications for both theory and practice in the area of health. ..
  24. Galanin Control of Food Intake: Molecular, Neuroanatomical and Behavioral Bases
    Eric P Zorrilla; Fiscal Year: 2010
    ....
  25. Role of the CRF2 Receptor in Ingestive Behavior
    Eric Zorrilla; Fiscal Year: 2005
    ..The proposed studies will address these questions as well to understand better the role of the CRF2 receptor in feeding behavior. ..
  26. 5-HT3 receptor mediation of 5-HT & CCK-induced satiation
    Matthew Hayes; Fiscal Year: 2005
    ....
  27. Childhood obesity treatment targeting specific behaviors
    Hollie Raynor; Fiscal Year: 2007
    ..Moreover, by comparing the effects of targeting the traditional or substitute behaviors, data will be obtained for a power analysis for a full-scale trial of the effects of these two approaches on long-term weight loss. ..
  28. Dorsomedial Hypothalamic Signaling Pathways and Energy Balance
    Sheng Bi; Fiscal Year: 2010
    ..Overall, the elucidation of the actions of these DMH peptide systems in feeding and body weight control would significantly advance our understanding of the role of this hypothalamic nucleus in maintaining energy homeostasis. ..
  29. SH2-B regulation of body weight and energy homeostasis
    Liangyou Rui; Fiscal Year: 2010
    ..3. Determine whether SH2-B differentially regulates leptin sensitivity in the LEPRb-neurons governing energy intake versus energy expenditure. ..
  30. Characterization of a novel brain cannabinoid ligand
    Daniele Piomelli; Fiscal Year: 2010
    ..The objective of our research is to understand how these transmitters are produced and eliminated, and discover innovative medicines that target these processes. ..
  31. EFFECTS OF CHANGING SEDENTARY BEHAVIOR IN OBESE CHILDREN
    Leonard Epstein; Fiscal Year: 2008
    ..Developing a better understanding of why obese youth increase physical activity or decrease energy intake when sedentary behaviors are reduced is important for the treatment of pediatric obesity. [unreadable] [unreadable] [unreadable]..
  32. Young Adult Environmental and Physical Activity Dynamics
    Barry Popkin; Fiscal Year: 2008
    ..No study heretofore has had large-scale groupings and in-depth environmental measures over time to examine these issues in a dynamic manner. ..
  33. Role of Endocannabinoids in the Behavioral Consequences of Social Isolation
    Daniele Piomelli; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  34. Peer Influence on Eating Behavior in Overweight and Normal Weight Youths
    Sarah Jeanne Salvy; Fiscal Year: 2008
    ..This study is designed to understand differences in responses to the social and food environment between overweight and non overweight youths. [unreadable] [unreadable] [unreadable]..
  35. BEHAVIORAL TOXICITY OF MDMA IN RHESUS MONKEYS
    MICHAEL TAFFE; Fiscal Year: 2009
    ..Specific Aim IV: To determine if a history of MDMA exposure impairs acquisition and performance of a battery of neuropsychological tests. ..
  36. Addressing Fear of Food in Anorexia Nervosa
    Joanna Steinglass; Fiscal Year: 2009
    ..This grant proposes a new and innovative treatment for patients with anorexia nervosa, which if successful, will reduce this high relapse rate and could have implications for acute treatment of anorexia nervosa, as well. ..
  37. Functional Brain Imaging and Appetite-Related Hormones Pre and Post Obesity Surge
    Allan Geliebter; Fiscal Year: 2008
    ..This may lead to improvements in the surgical procedures and to new insights into basic mechanisms that lead to obesity, which could provide the basis for new less invasive treatments. ..
  38. Diet, Activity, Obesity & The Built Environment Dynamics
    Barry Popkin; Fiscal Year: 2009
    ..A central issue is determining modifiable environment factors that may reduce ethnic and socioeconomic differentials in health status. ..
  39. Nutritional and Hormonal Determinants of Peak Bone Mass
    Madhusmita Misra; Fiscal Year: 2008
    ..The effects of estrogen in weight recovered vs. non-weight recovered AN will also be studied. ..
  40. Genes mediating glucopenia-induced obesity in nematodes
    Charles Mobbs; Fiscal Year: 2008
    ..These studies will suggest potential targets for anti-obesity drugs. ..
  41. Wise Mind: Environmental Approach for Obesity Prevention
    Donald Williamson; Fiscal Year: 2004
    ..abstract_text> ..
  42. Leptin and Neuroendocrine Gene Regulation in Obesity
    Judith Korner; Fiscal Year: 2005
    ..Leibel and Dr. Wardlaw, are experienced in basic and clinical research. They are easily accessible, enthusiastic about my projects, and will facilitate my transition to status as an independent investigator. ..
  43. PREVENTION OF OBESITY BY ALTERATION OF DIETARY FAT
    Joseph Donnelly; Fiscal Year: 2005
    ..The results of this study should advance our understanding of the role of dietary fat in the prevention of obesity and weight re-gain. ..
  44. AUTONOMIC DIABETIC NEUROPATHY IN MICE
    Charles Mobbs; Fiscal Year: 2004
    ..The present study should clarify the mechanisms and significance of glucose-sensitive hypothalamic and brainstem neurons in autonomic diabetic neuropathy. ..
  45. SIV Behavioral Pathology: Manipulation of Viral Load
    MICHAEL TAFFE; Fiscal Year: 2004
    ..abstract_text> ..
  46. Role of CNS Insulin in Learning and Memory
    Stephen Benoit; Fiscal Year: 2003
    ..Ultimately, this line of investigation may offer novel therapeutic strategies for treating individuals with cognitive disorders such as Alzheimer' s disease. ..
  47. GONADAL STEROID REGULATION OF THE BIOLOGICAL CLOCK
    Tamas Horvath; Fiscal Year: 2003
    ..abstract_text> ..
  48. PURDUE INTEGRATIVE NEUROSCIENCE PROGRAM
    TERRY POWLEY; Fiscal Year: 2002
    ..Students trained in the interdisciplinary Purdue Integrative Neuroscience program will make substantial contributions to mental health research and its applications in the next century. ..
  49. BCHE as a Cocaine Antagonist
    James Woods; Fiscal Year: 2002
    ..The possibility that human BChE can eventually be used as a safe and effective treatment of cocaine abuse and toxicity is being explored through these studies. ..
  50. Oleylethanolamide derivatives as anti-obesity agents
    Daniele Piomelli; Fiscal Year: 2005
    ....
  51. CRH Antagonists for Treatment of Drug Abuse
    James Woods; Fiscal Year: 2005
    ..This may provide information about the etiology of drug abuse, as well as data on the potential treatment of drug abuse in normal, or particularly, in stressed individuals. ..
  52. Uncoupling Protein 2 Promotes Neuronal Survival
    Tamas Horvath; Fiscal Year: 2006
    ..This will furnish one common target for the development of drugs against a variety of neurodegenerative pathologies, including those associated with hypoxia, epilepsy, Parkinson's, Alzheimer's and Huntington's Disease. ..
  53. Chromium Effects in Imparied Glucose Tolerance
    David Katz; Fiscal Year: 2006
    ..By contributing to knowledge related to potential diabetes prevention strategies, this study addresses one of the more pressing public health issues in the US today. ..
  54. Uncoupling Proteins and Species-Dependent Longevity
    Tamas Horvath; Fiscal Year: 2007
    ..Our attempts to provide comparative analyses of age related molecular mechanisms in rodents and nonhuman primates, will provide novel therapeutic targets, UCPs, to increase longevity without compromising tissue function. ..
  55. CENTRAL PEPTIDERGIC CIRCUITS IN METABOLISM REGULATION
    Tamas Horvath; Fiscal Year: 2007
    ..abstract_text> ..
  56. IV COCAINE ABUSE TREATMENT: A LABORATORY MODEL
    RICHARD FOLTIN; Fiscal Year: 2007
    ..abstract_text> ..
  57. Amygdala circuits and control of feeding by learned cues
    GORICA PETROVICH; Fiscal Year: 2007
    ..All facilities required for the proposed research are available to the applicant, including dedicated office and research space. ..
  58. LABORATORY ANALYSIS OF COCAINE ABSTINENCE
    RICHARD FOLTIN; Fiscal Year: 2007
    ..abstract_text> ..
  59. Syndecan & CNS Melanocortin Signaling in Energy Balance
    Stephen Benoit; Fiscal Year: 2007
    ..The results may provide important, basic insights into the control of body weight by the central melanocortin system and its recently identified co-receptor, syndecan-3. ..
  60. NARCOTIC DRUG AND OPIOID PEPTIDE BASIC RESEARCH PROJECT
    James Woods; Fiscal Year: 2006
    ..abstract_text> ..
  61. Melanin-Concentrating Hormone and Alcohol Intake
    Elizabeth Duncan; Fiscal Year: 2005
    ..The specific aims are: 1) To test the hypothesis that MCH is an endogenous factor regulating alcohol consumption and, 2) To test the hypothesis that MCH regulates the motivation to consume alcohol by modulating its reward properties. ..
  62. STOMACH CAPACITY AND EMPTYING IN OBESITY
    Allan Geliebter; Fiscal Year: 2001
    ..Body weight and composition will be assessed at the start and monthly. The studies may enhance knowledge of the etiology, pathophysiology, and treatment of BED. ..