vestibulo ocular reflex

Summary

Summary: A reflex wherein impulses are conveyed from the cupulas of the SEMICIRCULAR CANALS and from the OTOLITHIC MEMBRANE of the SACCULE AND UTRICLE via the VESTIBULAR NUCLEI of the BRAIN STEM and the median longitudinal fasciculus to the OCULOMOTOR NERVE nuclei. It functions to maintain a stable retinal image during head rotation by generating appropriate compensatory EYE MOVEMENTS.

Top Publications

  1. ncbi Cerebellum-dependent learning: the role of multiple plasticity mechanisms
    Edward S Boyden
    Department of Neurobiology, Stanford University, Stanford, California 94305, USA
    Annu Rev Neurosci 27:581-609. 2004
  2. ncbi Zonal organization of the mouse flocculus: physiology, input, and output
    Martijn Schonewille
    Department of Neuroscience, Erasmus MC, 3000 DR Rotterdam, The Netherlands
    J Comp Neurol 497:670-82. 2006
  3. ncbi Eye movement abnormalities in essential tremor may indicate cerebellar dysfunction
    C Helmchen
    Department of Neurology, University of Luebeck, Germany
    Brain 126:1319-32. 2003
  4. ncbi Evidence for interacting cortical control of vestibular function and spatial representation in man
    J Ventre-Dominey
    INSERM and CNRS Cognitive Sciences Institute UMR 5015, 67 Bd Pinel, 69500, Bron, France
    Neuropsychologia 41:1884-98. 2003
  5. ncbi Cerebellar LTD facilitates but is not essential for long-term adaptation of the vestibulo-ocular reflex
    A M Van Alphen
    Department of Neuroscience, Erasmus University Rotterdam, Dr Molenwaterplein 50, 3000 DR Rotterdam, The Netherlands
    Eur J Neurosci 16:486-90. 2002
  6. ncbi Cerebellar signatures of vestibulo-ocular reflex motor learning
    Pablo M Blazquez
    Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 23:9742-51. 2003
  7. ncbi Active reversal of motor memories reveals rules governing memory encoding
    Edward S Boyden
    Department of Neurobiology, Stanford University, Stanford, CA 94305, USA
    Neuron 39:1031-42. 2003
  8. ncbi Vestibular perception and action employ qualitatively different mechanisms. II. VOR and perceptual responses during combined Tilt&Translation
    Daniel M Merfeld
    Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Room 421, MEEI, 243 Charles St, Boston, Massachusetts 02114, USA
    J Neurophysiol 94:199-205. 2005
  9. ncbi The vestibulo-ocular reflex as a model system for motor learning: what is the role of the cerebellum?
    Pablo M Blazquez
    Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cerebellum 3:188-92. 2004
  10. ncbi Vestibuloocular reflex dynamics during high-frequency and high-acceleration rotations of the head on body in rhesus monkey
    Marko Huterer
    Aerospace Medical Research Unit, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Neurophysiol 88:13-28. 2002

Detail Information

Publications196 found, 100 shown here

  1. ncbi Cerebellum-dependent learning: the role of multiple plasticity mechanisms
    Edward S Boyden
    Department of Neurobiology, Stanford University, Stanford, California 94305, USA
    Annu Rev Neurosci 27:581-609. 2004
    ..These principles emerging from studies of the VOR are consistent with results concerning more complex behaviors and thus may reflect general principles of cerebellar function...
  2. ncbi Zonal organization of the mouse flocculus: physiology, input, and output
    Martijn Schonewille
    Department of Neuroscience, Erasmus MC, 3000 DR Rotterdam, The Netherlands
    J Comp Neurol 497:670-82. 2006
    ..The present study illustrates that Purkinje cells in the murine flocculus are organized in discrete zones with specific functions, specific input - output relations, and a specific histochemical signature...
  3. ncbi Eye movement abnormalities in essential tremor may indicate cerebellar dysfunction
    C Helmchen
    Department of Neurology, University of Luebeck, Germany
    Brain 126:1319-32. 2003
    ..The oculomotor deficits may indicate an impairment of the caudal vermis in ET...
  4. ncbi Evidence for interacting cortical control of vestibular function and spatial representation in man
    J Ventre-Dominey
    INSERM and CNRS Cognitive Sciences Institute UMR 5015, 67 Bd Pinel, 69500, Bron, France
    Neuropsychologia 41:1884-98. 2003
    ..e. in right cortical lesions with hemi-neglect syndrome. These results demonstrate in man, the existence of a cortical influence on vestibular function related to the mechanisms of spatial representation...
  5. ncbi Cerebellar LTD facilitates but is not essential for long-term adaptation of the vestibulo-ocular reflex
    A M Van Alphen
    Department of Neuroscience, Erasmus University Rotterdam, Dr Molenwaterplein 50, 3000 DR Rotterdam, The Netherlands
    Eur J Neurosci 16:486-90. 2002
    ..Thus, while LTD may be necessary for short-term VOR adaptation, it facilitates but is not required for long-term adaptation of the VOR...
  6. ncbi Cerebellar signatures of vestibulo-ocular reflex motor learning
    Pablo M Blazquez
    Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 23:9742-51. 2003
    ..We provide evidence that all of these changes are necessary for VOR behavior and can explain learning deficits after cerebellar removal...
  7. ncbi Active reversal of motor memories reveals rules governing memory encoding
    Edward S Boyden
    Department of Neurobiology, Stanford University, Stanford, CA 94305, USA
    Neuron 39:1031-42. 2003
    ..Contrary to previous models about memory encoding by the cerebellum, our results indicate that these behavioral changes are implemented by different plasticity mechanisms, which reverse each other with unequal efficacy...
  8. ncbi Vestibular perception and action employ qualitatively different mechanisms. II. VOR and perceptual responses during combined Tilt&Translation
    Daniel M Merfeld
    Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Room 421, MEEI, 243 Charles St, Boston, Massachusetts 02114, USA
    J Neurophysiol 94:199-205. 2005
    ..We conclude that internal models govern human perception of tilt and translation at 0.8 Hz and that high-pass filtering governs the human translational VOR at this same frequency...
  9. ncbi The vestibulo-ocular reflex as a model system for motor learning: what is the role of the cerebellum?
    Pablo M Blazquez
    Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cerebellum 3:188-92. 2004
    ..We further propose that these changes are necessary to maintain the broadband characteristics of the learned behavior...
  10. ncbi Vestibuloocular reflex dynamics during high-frequency and high-acceleration rotations of the head on body in rhesus monkey
    Marko Huterer
    Aerospace Medical Research Unit, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Neurophysiol 88:13-28. 2002
    ..We conclude that the VOR is compensatory over a wide frequency range in monkeys and has similar response dynamics during passive rotation of the head on body as during passive rotation of the whole body in space...
  11. ncbi A critical period for functional vestibular development in zebrafish
    Stephen J Moorman
    Department of Anatomy, Case Western Reserve University, School of Medicine, Cleveland, OH 44106 4930, USA
    Dev Dyn 223:285-91. 2002
    ..The developmental period identified includes the timeframe during which the vestibular primary afferent neurons are born, innervate their central and peripheral targets, and remodel their central projections...
  12. ncbi Capacity of vertical VOR adaptation in squirrel monkey
    Y Hirata
    Department of Electronic Engineering, Chubu University College of Engineering, Kasugai, Aichi 487 8501, Japan
    J Neurophysiol 88:3194-207. 2002
    ..These results confine the adaptive site(s) responsible for vertical VOR motor learning to those that can process up and downward or low- and high-frequency head signal separately but not completely independently...
  13. pmc Normal performance and expression of learning in the vestibulo-ocular reflex (VOR) at high frequencies
    Ramnarayan Ramachandran
    Deptartment of Physiology, Howard Hughes Medical Institute and W M Keck Center for Integrative Neuroscience, University of California at San Francisco, 513 Parnassus Ave, Box 0444, San Francisco, CA 94143 0444, USA
    J Neurophysiol 93:2028-38. 2005
    ..We were able to reproduce the main features of our data with a two-pathway model of the VOR, where the two pathways had different relationships between phase shift and frequency...
  14. ncbi Eye movements of the murine P/Q calcium channel mutant tottering, and the impact of aging
    John S Stahl
    Dept of Neurology, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106 5040, USA
    J Neurophysiol 95:1588-607. 2006
    ..The data suggest at least four pathophysiological mechanisms (two congenital and two acquired) are required to explain the ocular motor deficits in the two Cacna1a mutant strains...
  15. ncbi Acute adaptation of the vestibuloocular reflex: signal processing by floccular and ventral parafloccular Purkinje cells
    Y Hirata
    Department of Electronic Engineering, Chubu University College of Engineering, Aichi 487-8501, Japan
    J Neurophysiol 85:2267-88. 2001
    ..This apparent incorrect directional change might serve to prevent instability of the VOR caused by positive feedback via the efference copy pathway...
  16. ncbi Memory trace of motor learning shifts transsynaptically from cerebellar cortex to nuclei for consolidation
    F Shutoh
    Laboratory for Motor Learning Control, RIKEN Brain Science Institute, Hirosawa 2 1, Wako, Saitama 351 0198, Japan
    Neuroscience 139:767-77. 2006
    ....
  17. pmc Orientation of human semicircular canals measured by three-dimensional multiplanar CT reconstruction
    Charles C Della Santina
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, 601 North Caroline Street, Rm JHOC 6253, Baltimore, MD 21287, USA
    J Assoc Res Otolaryngol 6:191-206. 2005
    ..5 +/- 5.1 degrees, and 105.6 +/- 6.6 degrees, respectively. The mean anterior SCC-contralateral posterior SCC angle was 15.3 +/- 7.2 degrees. The absolute orientations of human SCC are more nearly orthogonal than previously reported...
  18. ncbi The vestibulo ocular reflex (VOR) in otoconia deficient head tilt (het) mutant mice versus wild type C57BL/6 mice
    Christopher G Harrod
    Northwestern University, Department of Physiology and Institute for Neuroscience, 303 East Chicago Avenue, M211, Chicago, IL 60611, USA
    Brain Res 972:75-83. 2003
    The horizontal and vertical vestibulo ocular reflex (VOR) of head tilted (het) mutant mice was compared to C57BL/6 controls. Eye movements were recorded in darkness using a temporarily attached search coil...
  19. ncbi Intrinsic and synaptic plasticity in the vestibular system
    Aryn H Gittis
    Howard Hughes Medical Institute and Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Neurobiol 16:385-90. 2006
    ..Mechanistic analyses of a novel form of firing rate potentiation in neurons of the vestibular nucleus have revealed new rules of plasticity that could apply to spontaneously firing neurons in other parts of the brain...
  20. ncbi Vestibulo-ocular dysfunction induced by cortical damage in man: a case report
    J Ventre-Dominey
    INSERM Unité 94, Laboratoire Vision et Motricite, Bron, France
    Neuropsychologia 37:715-21. 1999
    ..This cortical processing of vestibular integration might involve a multidimensional velocity storage integrator that subserves the maintenance of spatial coordinates along the spatial vertical axis...
  21. ncbi Quantifying the ontogeny of optokinetic and vestibuloocular behaviors in zebrafish, medaka, and goldfish
    James C Beck
    Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016, USA
    J Neurophysiol 92:3546-61. 2004
    ..In contrast, larval fish seem to be unique among vertebrates tested in their lack of significant angular VOR at stages where active movement is required for feeding and survival...
  22. ncbi Role of the dorsolateral pontine nucleus in short-term adaptation of the horizontal vestibuloocular reflex
    Seiji Ono
    Division of Visual Science, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30022, USA
    J Neurophysiol 89:2879-85. 2003
    ..Our results suggest that visual error signals for short-term adaptation of the VOR are derived from sources other than the DLPN perhaps including other basilar pontine nuclei and the accessory optic system...
  23. ncbi Using video-oculography for galvanic evoked vestibulo-ocular monitoring in comatose patients
    Hans Georg Schlosser
    Department of Neurosurgery, Charite Campus Virchow Clinic, Universitatsmedizin Berlin, Berlin, Germany
    J Neurosci Methods 145:127-31. 2005
    ..The designed monitoring facility can be used on the ICU ward without disconnection of other monitoring equipment...
  24. ncbi alphaCaMKII Is essential for cerebellar LTD and motor learning
    Christian Hansel
    Department of Neuroscience, Erasmus MC, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Neuron 51:835-43. 2006
    ..Since Purkinje cells are the only cells in the cerebellum that express alphaCaMKII, our data suggest that an impairment of parallel fiber LTD, while leaving LTP intact, is sufficient to disrupt this form of cerebellar learning...
  25. ncbi The site of a motor memory shifts with consolidation
    Charles D Kassardjian
    Division of Cellular and Molecular Biology, Toronto Western Research Institute, University Health Network, Toronto, Ontario, M5T 2S8, Canada
    J Neurosci 25:7979-85. 2005
    ....
  26. ncbi Oculomotor plasticity during vestibular compensation does not depend on cerebellar LTD
    M Faulstich
    Systems Neurobiology Laboratory, Salk Institute, La Jolla, CA, USA
    J Neurophysiol 96:1187-95. 2006
    ..We conclude that oculomotor plasticity during vestibular compensation depends critically on intact cerebellar circuitry but not on the occurrence of cerebellar LTD...
  27. ncbi Time and tide in cerebellar memory formation
    Chris I De Zeeuw
    Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands
    Curr Opin Neurobiol 15:667-74. 2005
    ....
  28. pmc Dependence of the roll angular vestibuloocular reflex (aVOR) on gravity
    Sergei B Yakushin
    Dept of Neurology, Box 1135, Mount Sinai School of Medicine, 1 E 100th St, New York, NY 10029 6574, USA
    J Neurophysiol 102:2616-26. 2009
    ..These behavioral differences support the idea that there is a fundamental difference in the central organization of canal-otolith convergence of the roll and yaw/pitch aVORs...
  29. ncbi Recording three-dimensional eye movements: scleral search coils versus video oculography
    Mark M J Houben
    Department of Neuroscience, Erasmus University Medical Center, Rotterdam, The Netherlands
    Invest Ophthalmol Vis Sci 47:179-87. 2006
    ..This study compared the performance of a video-based infrared three-dimensional eye tracker device (Chronos) with the scleral search coil method...
  30. pmc Impairment of LTD and cerebellar learning by Purkinje cell-specific ablation of cGMP-dependent protein kinase I
    Robert Feil
    Institut fur Pharmakologie und Toxikologie, Technische Universitat, Biedersteiner Str 29, D 80802 München, Germany
    J Cell Biol 163:295-302. 2003
    ..These results indicate that cGKI in PCs is dispensable for general motor coordination, but that it is required for cerebellar LTD and specific forms of motor learning, namely the adaptation of the VOR...
  31. ncbi An internal model of head kinematics predicts the influence of head orientation on reflexive eye movements
    L H Zupan
    Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02114, USA
    J Neural Eng 2:S180-97. 2005
    ..These predictions are consistent with experimental data...
  32. pmc Temporal dynamics of ocular position dependence of the initial human vestibulo-ocular reflex
    Benjamin T Crane
    Department of Surgery Division of Otolaryngology, University of California, Los Angeles 90095 7002, USA
    Invest Ophthalmol Vis Sci 47:1426-38. 2006
    ..The present study was conducted to explore the recent proposal that the VOR's rotational axis is not collinear with the head's, but rather follows a time-dependent strategy intermediate between LL and an ideal VOR...
  33. ncbi The human horizontal vestibulo-ocular reflex in response to active and passive head impulses after unilateral vestibular deafferentation
    G M Halmagyi
    Department of Neurology, Royal Prince Alfred Hospital, Sydney, Australia
    Ann N Y Acad Sci 1004:325-36. 2003
    ..After 75 ms, rapid corrective eye movements often were generated to reduce any remaining gaze error...
  34. ncbi Memory retention of vestibuloocular reflex motor learning in squirrel monkeys
    Y Kuki
    Department of Otolaryngology, Washington University, School of Medicine, St Louis, MO 63110, USA
    Neuroreport 15:1007-11. 2004
    ..Our data is compatible with the idea that cerebellar LTD might be a mechanism responsible for acute VOR adaptation...
  35. ncbi The three-dimensional vestibulo-ocular reflex evoked by high-acceleration rotations in the squirrel monkey
    Americo A Migliaccio
    Department of Otolaryngology Head and Neck Surgery, Ross Building, Room 710, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Exp Brain Res 159:433-46. 2004
    ..In addition, we show that the gain, phase and axis of eye rotation during LARP and RALP head rotations can be predicted once the pitch and roll responses are characterized...
  36. ncbi Characteristics of the VOR in response to linear acceleration
    G D Paige
    Department of Neurobiology and Anatomy, University of Rochester, New York 14642, USA
    Ann N Y Acad Sci 871:123-35. 1999
    ..Interestingly, the usual high-pass dynamics of these reflexes shift to an even higher cutoff. Both eyes respond roughly equally, suggesting that unilateral otolith input generates a binocularly symmetric LVOR...
  37. ncbi Recurrent cerebellar loops simplify adaptive control of redundant and nonlinear motor systems
    John Porrill
    Centre for Signal Processing in Neuroimaging and Systems Neuroscience, Department of Psychology, University of Sheffield, Sheffield S10 2TP, UK
    Neural Comput 19:170-93. 2007
    ..These properties suggest a central functional role for the closed cerebellar loops, which have been shown to be ubiquitous in motor systems (e.g., Kelly & Strick, 2003)...
  38. ncbi Chronic changes in inputs to dorsal Y neurons accompany VOR motor learning
    Pablo M Blazquez
    Dept of Otolaryngology, Washington University School of Medicine, 4566 Scott Ave, St Louis, MO 63110, USA
    J Neurophysiol 95:1812-25. 2006
    ....
  39. ncbi Contribution of the otoliths to the human torsional vestibulo-ocular reflex
    E Groen
    TNO Human Factors Research Institute, DE Soesterberg, The Netherlands
    J Vestib Res 9:27-36. 1999
    ..We conclude that the primary concern of the otolith-oculomotor system during head tilt is to stabilize eye position in space, rather than to prevent retinal blur...
  40. ncbi Context-specific short-term adaptation of the phase of the vestibulo-ocular reflex
    P D Kramer
    Department of Neurology, The Johns Hopkins University, School of Medicine, Baltimore, MD 21287, USA
    Exp Brain Res 120:184-92. 1998
    ..Such context-specific adaptation is advantageous, because it allows adjustment of the phase of the VOR without degrading the ability to hold eccentric fixation...
  41. ncbi Computational study on monkey VOR adaptation and smooth pursuit based on the parallel control-pathway theory
    Hiromitsu Tabata
    Kawato Dynamic Brain Project, ERATO, Japan Science and Technology Corporation, Kyoto 619 0288, Japan
    J Neurophysiol 87:2176-89. 2002
    ..Finally, we propose behavioral and physiological experiments capable of discriminating between these two possibilities for the site of pursuit driving command maintenance and hence for the sites of learning and memory for VOR adaptation...
  42. ncbi Characterization of the vestibulo-ocular reflex evoked by high-velocity movements
    Francois D Roy
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada
    Laryngoscope 114:1190-3. 2004
    ..The aim of the research was to evaluate and characterize the normal behavior of the reflex evoked by high-velocity head rotations...
  43. ncbi Torsional dynamics and cross-coupling in the human vestibulo-ocular reflex during active head rotation
    H Misslisch
    Department of Neurology, University of Tubingen, Germany
    J Vestib Res 10:119-25. 2000
    ..The drop in torsional gain at low frequencies can be explained based on the leak in the neural integrator that helps convert torsional eye-velocity commands into eye-position commands...
  44. ncbi Human 3-D aVOR with and without otolith stimulation
    Christopher J Bockisch
    Department of Neurology, University Hospital Zurich, Frauenklinikstr 26, 8091 Zurich, Switzerland
    Exp Brain Res 161:358-67. 2005
    ..This could be because, in humans, typical yaw head movements will stimulate the otoliths to a much lesser extent then typical pitch and roll head movements...
  45. ncbi Expression of protein kinase C inhibitor blocks cerebellar long-term depression without affecting Purkinje cell excitability in alert mice
    J Goossens
    Department of Physiology, Neuroscience Institute, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
    J Neurosci 21:5813-23. 2001
    ....
  46. ncbi Distinct patterns of stimulus generalization of increases and decreases in VOR gain
    Rhea R Kimpo
    Dept of Neurobiology, Stanford University, 299 W Campus Dr, Stanford, CA 94305 5125, USA
    J Neurophysiol 94:3092-100. 2005
    ..At one or more sites, the plasticity mechanisms supporting decreases in VOR gain must be less synapse-specific, or affect neurons more broadly tuned for head rotation frequency, than the mechanisms supporting increases in gain...
  47. ncbi Human angular vestibulo-ocular reflex initiation: relationship to Listing's law
    Benjamin T Crane
    Department of Surgery, University of California, Los Angeles, CA 90032, USA
    Ann N Y Acad Sci 1039:26-35. 2005
    ....
  48. ncbi Human angular vestibulo-ocular reflex axis disconjugacy: relationship to magnetic resonance imaging evidence of globe translation
    Joseph L Demer
    Department of Opthalmology Surgery, Jules Stein Eye Institute, University of California, CA 90095 7002, USA
    Ann N Y Acad Sci 1039:15-25. 2005
    ..Confirmation of predicted duction-dependent VOR disconjugacy supports the idea that rectus pulleys influence kinematics for all eye movements...
  49. ncbi Torsional vestibulo-ocular reflex during whole-body oscillation in the upright and the supine position. I. Responses in healthy human subjects
    A Schmid-Priscoveanu
    Department of Neurology, Zurich University Hospital, Switzerland
    Exp Brain Res 134:212-9. 2000
    ..05 to 1.0 Hz. This normal database is crucial for the interpretation of results obtained in patients with vestibular disorders...
  50. ncbi Cerebellar AMPA/KA receptor antagonism by CNQX inhibits vestibuloocular reflex adaptation
    Troy L Carter
    Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, PA 19140, USA
    Exp Brain Res 166:157-69. 2005
    ..Because the AMPA/KA receptors are located only in the molecular layer of the goldfish cerebellum, these results are, presumably, the result of AMPA/KA receptor antagonism at synapses located on the Purkinje cell dendrite tree...
  51. ncbi Functions of the nucleus of the optic tract (NOT). I. Adaptation of the gain of the horizontal vestibulo-ocular reflex
    S B Yakushin
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Exp Brain Res 131:416-32. 2000
    ..Pathways through the inferior olive are presumably important for this adaptation...
  52. ncbi Principles of linear and angular vestibuloocular reflex organization in the frog
    M Rohregger
    Physiologisches Institut der Ludwig Maximilians Universität, 80336 Munich, Germany
    J Neurophysiol 87:385-98. 2002
    ..The mutual adaptation of angular and linear vestibuloocular reflexes as well as the differences in their organization described here for frogs may represent a basic feature common for vertebrates in general...
  53. ncbi Early components of the human vestibulo-ocular response to head rotation: latency and gain
    H Collewijn
    Department of Physiology, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
    J Neurophysiol 84:376-89. 2000
    ..A near visual target caused VOR gain to rise to a higher level, but the time after which the difference between far and near targets emerged varied between individuals...
  54. ncbi Short-term adaptation of the cervico-ocular reflex
    D C Rijkaart
    Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands
    Exp Brain Res 156:124-8. 2004
    ..Analysis showed a small but significant reduction in COR gain in the suppression conditions. This means that the cervico-ocular reflex can be modified after only 10 min of concurrent visual and cervical stimulation...
  55. pmc Three dimensional kinematics of rapid compensatory eye movements in humans with unilateral vestibular deafferentation
    Jun Ru Tian
    Department of Ophthalmology, University of California, Los Angeles, CA 90095 7002, USA
    Exp Brain Res 182:143-55. 2007
    ..ADs have kinematics that neither conform to LL nor match the VOR axis, but appear instead programmed in 3D to correct VOR axis errors...
  56. ncbi Cervico-ocular reflex in normal subjects and patients with unilateral vestibular hypofunction
    Michael C Schubert
    Laboratory of Vestibular Neurophysiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Otol Neurotol 25:65-71. 2004
    ..To determine whether the cervico-ocular reflex contributes to gaze stability in patients with unilateral vestibular hypofunction...
  57. ncbi Ocular rotation axes during dynamic Bielschowsky head-tilt testing in unilateral trochlear nerve palsy
    Konrad P Weber
    Department of Neurology, Zurich University Hospital, Zurich, Switzerland
    Invest Ophthalmol Vis Sci 45:455-65. 2004
    ..To explain the positive Bielschowsky head-tilt (BHT) sign in unilateral trochlear nerve palsy (uTNP) by the kinematics of three-dimensional eye rotations...
  58. ncbi The critical role of velocity storage in production of motion sickness
    Bernard Cohen
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Ann N Y Acad Sci 1004:359-76. 2003
    ....
  59. ncbi Eye velocity asymmetry, ocular orientation, and convergence induced by angular rotation in the rabbit
    Jun Maruta
    Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA
    Vision Res 46:961-9. 2006
    ..Thus, mechanisms in the rabbit increase compensatory eye velocity in the eye that leads into the direction of rotation and enhance binocular vision...
  60. ncbi Dissociated hysteresis of static ocular counterroll in humans
    A Palla
    Department of Neurology, Zurich University Hospital, Zurich, Switzerland
    J Neurophysiol 95:2222-32. 2006
    ..We hypothesize that ocular torsional hysteresis is introduced at the level of the otolith pathways because the direction-dependent torsional position lag of the eyes is related to the head roll position and not the eye position...
  61. pmc A multichannel semicircular canal neural prosthesis using electrical stimulation to restore 3-d vestibular sensation
    Charles C Della Santina
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, 601 North Caroline Street, Baltimore, MD 21287, USA
    IEEE Trans Biomed Eng 54:1016-30. 2007
    ..Increasing stimulation selectivity via improvements in electrode design, surgical technique and stimulus protocol will likely be required to restore AVOR function over the full range of normal behavior...
  62. ncbi Nonlinear nystagmus processing causes torsional VOR nonlinearity
    E Schneider
    Ludwig Maximilians University, Department of Neurology and Center for Sensorimotor Research, Munich, Germany
    Ann N Y Acad Sci 1004:500-5. 2003
    ..This method proved to be suitable for determining whether nonlinear processing of nystagmus frequency is responsible for the TVOR nonlinearity...
  63. ncbi A reevaluation of the inverse dynamic model for eye movements
    Andrea M Green
    Departement de Physiologie, Universite de Montreal, Montreal, Quebec, Canada H3T 1J4
    J Neurosci 27:1346-55. 2007
    ..They encode and distribute an estimate of the motor command, a signal critical for accurate motor execution and learning...
  64. ncbi Vestibulo-ocular function in anxiety disorders
    Joseph M Furman
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Vestib Res 16:209-15. 2006
    ..Excessive SMD and height phobia seem to have a mitigating effect on abnormal vestibular sensitivity, possibly via a down-weighting of central vestibular pathways...
  65. ncbi Interstitial nucleus of cajal encodes three-dimensional head orientations in Fick-like coordinates
    Eliana M Klier
    Department of Anatomy and Neurobiology, Box 8108, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Neurophysiol 97:604-17. 2007
    ..These data support a simple mechanism for controlling head orientation through the alignment of brain stem neural coordinates with natural behavioral constraints...
  66. ncbi Pulse-step-sine rotation test for the identification of abnormal vestibular function
    Robert J Peterka
    Neurological Sciences Institute, Oregon Health and Science University, Portland, Oregon 97006, USA
    J Vestib Res 15:291-311. 2005
    ....
  67. ncbi Vestibular and non-vestibular contributions to eye movements that compensate for head rotations during viewing of near targets
    Yanning H Han
    Department of Biomedical Engineering, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106 5040, USA
    Exp Brain Res 165:294-304. 2005
    ..Comparison with previous studies indicates that mechanisms for generation of eye rotations during near viewing depend on head stimulus type (rotation or translation), waveform (transient or sinusoidal), and the species being tested...
  68. ncbi Otolith deprivation induces optokinetic compensation
    Corina E Andreescu
    Department of Neuroscience, Erasmus University Medical Center Rotterdam, DR Rotterdam, The Netherlands
    J Neurophysiol 94:3487-96. 2005
    ....
  69. ncbi Efficacy of tilt-suppression in postrotatory nystagmus in cats
    Hiroaki Fushiki
    Department of Otolaryngology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama shi, Toyama 930 0194, Japan
    Brain Res 1108:127-32. 2006
    ....
  70. pmc Effect of unilateral vestibular deafferentation on the initial human vestibulo-ocular reflex to surge translation
    Jun Ru Tian
    Department of Ophthalmology, University of California, Los Angeles, California 90095 7002, USA
    Exp Brain Res 176:575-87. 2007
    ..Chronic human UVD, on average, significantly impairs the surge LVOR for horizontally eccentric targets placed ipsilesionally, but this asymmetry is small relative to interindividual variation...
  71. ncbi A least-squares parameter estimation algorithm for switched hammerstein systems with applications to the VOR
    Sunil L Kukreja
    NASA Dryden Flight Research Center, Edwards, CA 93523 0273, USA
    IEEE Trans Biomed Eng 52:431-44. 2005
    ..The approach will also allow the identification of other nonlinear bio-systems, suspected of containing "hard" nonlinearities...
  72. ncbi Vestibular perception and action employ qualitatively different mechanisms. I. Frequency response of VOR and perceptual responses during Translation and Tilt
    Daniel M Merfeld
    Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Room 421, MEEI, 243 Charles St, Boston, Massachusetts 02114, USA
    J Neurophysiol 94:186-98. 2005
    ..2 hz...
  73. ncbi Gravity-dependent and gravity-independent gain changes during vertical vestibulo-ocular reflex (VOR) adaptation
    Yongqing Xiang
    Department of Computer and Information Science, Brooklyn College of the City University of New York, Brooklyn, New York 11210, USA
    J Gravit Physiol 11:P9-12. 2004
    ..We conclude that the alteration in gain of the aVOR always occurs in the context of gravity...
  74. ncbi Orienting eye movements and nystagmus produced by translation while rotating (TWR)
    Jun Maruta
    Department of Neurology and Physiology and Biophysics, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    Exp Brain Res 163:273-83. 2005
    ..We speculate that the brain may use these low amplitude rotating linear accelerations to generate eye velocities that help to orient gaze when making turns during normal locomotion...
  75. ncbi Spatial properties of central vestibular neurons of monkeys after bilateral lateral canal nerve section
    Sergei B Yakushin
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Neurophysiol 94:3860-71. 2005
    ..There were substantial neck and/or otolith-related inputs activating the vertical canal-related neurons in the nerve-sectioned animals, which could have contributed to oculomotor compensation after nerve section...
  76. ncbi Vestibular gaze stabilization: different behavioral strategies for arboreal and terrestrial avians
    Asim Haque
    Deptartment of Anatomy and Neurobiology, Washington University School of Medicine, Campus Box 8108, 660 S Euclid, St Louis, MO 63110, USA
    J Neurophysiol 93:1165-73. 2005
    ..These results suggest that disparity between the stabilization strategies employed by these two birds may be attributed to differences in species-specific behavior and anatomy...
  77. ncbi Effect of angular acceleration on the localization performance of a remembered target
    Frank Schmäl
    Department of Otorhinolaryngology, University Hospital Munster, Germany
    J Vestib Res 15:81-92. 2005
    ....
  78. ncbi Visually enhanced vestibulo-ocular reflex: a diagnostic tool for migraine vestibulopathy
    Moises A Arriaga
    Pittsburgh Ear Associates, Pittsburgh, Pennsylvania, USA
    Laryngoscope 116:1577-9. 2006
    ....
  79. ncbi Asymmetric adaptive gain changes of the vertical vestibulo-ocular reflex in cats
    Motoyoshi Maruyama
    Department of Otolaryngology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Brain Res 1023:302-8. 2004
    ..Possible explanations for the asymmetry are discussed on a physiological and anatomical basis...
  80. ncbi [Head shaking test (HSN) using to diagnose vestibule damage]
    Alina Morawiec-Bajda
    Oddział Kliniczny Chirurgii Nowotworów Głowy i Szyi Uniwersytetu Medycznego w Lodzi
    Otolaryngol Pol 60:407-13. 2006
    ..Estimation of HSN test value to show asymmetrical function of vestibular system 3. Establish possibility of HSN test to localization of damage vestibular system 4. Verification this test to use it as screening test..
  81. ncbi Do motoneurons encode the noncommutativity of ocular rotations?
    Fatema F Ghasia
    Department of Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 47:281-93. 2005
    ....
  82. ncbi Interaction between otolith organ and semicircular canal vestibulo-ocular reflexes during eccentric rotation in humans
    Claire C Gianna-Poulin
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Exp Brain Res 185:485-95. 2008
    ..e. algebraic summation) between otolith organ and horizontal canal VORs for the generation of horizontal compensatory eye movements during head motion...
  83. ncbi Vertical (Z-axis) acceleration alters the ocular response to linear acceleration in the rabbit
    Jun Maruta
    Department of Neurology, Mount Sinai School of Medicine, Box 1135, 1 Gustave L Levy Place, New York, NY 10029, USA
    Exp Brain Res 185:87-99. 2008
    ....
  84. ncbi The high-frequency/acceleration head heave test in detecting otolith diseases
    Paul Kessler
    Department of Otolaryngology, University of Toronto, Toronto, Ontario, Canada
    Otol Neurotol 28:896-904. 2007
    ..To investigate whether transient, high-acceleration interaural head heaves (translational vestibulo-ocular reflex [tVOR]) could aid in the diagnosis of otolith diseases...
  85. ncbi Vestibulo-ocular physiology underlying vestibular hypofunction
    Michael C Schubert
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, 710 Ross Bldg, 720 Rutland Ave, Baltimore, MD 21205, USA
    Phys Ther 84:373-85. 2004
    ..The purposes of this article are to review the anatomy and physiology of the vestibular system and to describe the neurophysiological mechanisms responsible for the vestibulo-ocular abnormalities in patients with vestibular hypofunction...
  86. ncbi Adaptive plasticity in the otolith-ocular reflex
    Izumi Koizuka
    Department of Otolaryngology, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki City, 216 8511, Kanagawa, Japan
    Auris Nasus Larynx 30:S3-6. 2003
    ..We believe that the ScOR and the OOR share common neural pathways in such a way that a change in the synaptic efficacy of one pathway is accompanied by a change in the other...
  87. ncbi Orientation of Listing's plane during static tilt in young and older human subjects
    Joseph M Furman
    Department of Otolaryngology, School of Medicine, University of Pittsburgh, EEI Bldg, Ste 500, Pittsburgh, PA 15213, USA
    Vision Res 43:67-76. 2003
    ..The only obvious difference between the two age groups was that the "thickness" of Listing's plane was greater in the older subjects. This suggests that aging has a small, but definite, influence on Listing's law...
  88. ncbi Motorized head impulse stimulator to determine angular horizontal vestibulo-ocular reflex
    H Aalto
    Department of Otorhinolaryngology, Helsinki University, Central Hospital, Helsinki, Finland
    J Med Eng Technol 26:217-22. 2002
    ..After having executed preliminary experiments at our balance laboratory we found the system to be efficient, reliable and secure...
  89. ncbi Noncommutative control in the rotational vestibuloocular reflex
    Tamara Tchelidze
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    J Neurophysiol 99:96-111. 2008
    ..This restriction implies a limited oculomotor range in torsion and systematic tilts of the angular eye velocity as a function of gaze direction...
  90. ncbi Combined influence of vergence and eye position on three-dimensional vestibulo-ocular reflex in the monkey
    H Misslisch
    Department of Neurology, University of Zurich, 8091 Zurich, Switzerland
    J Neurophysiol 88:2368-76. 2002
    ....
  91. ncbi [Bilateral vestibular areflexia: quantification is required]
    E Ulmer
    Service ORL et Chirurgie Cervico Faciale, CHU Nord, 13915 Marseille Cedex 20, France
    Ann Otolaryngol Chir Cervicofac 119:216-26. 2002
    ..The apparent vestibular loss is actually related to stimulation frequency. This phenomenon could be explained by considering the physiology of phasic and tonic cells...
  92. ncbi Context-specific adaptation of the gain of the oculomotor response to lateral translation using roll and pitch head tilts as contexts
    Mark Shelhamer
    2 210 Pathology Bldg, Johns Hopkins Hospital, Baltimore, MD 21287 6921, USA
    Exp Brain Res 146:388-93. 2002
    ..Head pitch tilt was less effective as a context cue. This suggests that the more closely related a context cue is to the response being adapted, the more effective it is...
  93. ncbi The vestibulo-ocular reflex in fourth nerve palsy: deficits and adaptation
    Agnes M F Wong
    Division of Neurology, University of Toronto, University Health Network, Toronto Western Hospital, 5 440 WW, 399 Bathurst Street, Ont, M5T 2S8, Toronto, Canada
    Vision Res 42:2205-218. 2002
    ..Motions of the eyes after fourth nerve palsy exemplify monocular adaptation of the VOR, in response to peripheral neuromuscular deficits...
  94. ncbi Recovery of gaze stability during vestibular regeneration
    Asim Haque
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Neurophysiol 99:853-65. 2008
    ..This was true even though the head-fixed VOR response recovered normally. Recovery of gaze stability coincided well with the three stage temporal sequence of morphologic regeneration previously described by our laboratory...
  95. pmc Eye orientation during static tilts and its relationship to spontaneous head pitch in the laboratory mouse
    Brian S Oommen
    Case Western Reserve University School of Medicine, Cleveland, OH 44106 5040, USA
    Brain Res 1193:57-66. 2008
    ..The robust tiltMOR also has significant methodological implications for the practice of pupil-tracking video oculography in this species...
  96. ncbi Human smooth pursuit gain is modulated by a signal related to gaze velocity
    Otmar Bayer
    Department of Neurology, Ludwig Maximilians University, Munich, Germany
    Neuroreport 19:1217-20. 2008
    ..Analysis of variance revealed that the target ([almost equal to]gaze) velocity had a significant and equal influence in both headfixed and headfree conditions. This finding indicates that gaze velocity modulates the response...
  97. ncbi Relationship between time- and frequency-domain analyses of angular head movements in the squirrel monkey
    M Armand
    Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, MD 21287-0910, USA
    J Comput Neurosci 11:217-39. 2001
    ..We show that the wavelet transform, a novel method as applied to the signal analysis goals of this study, is the most useful technique for relating time- and frequency-domain information during a continuous signal...
  98. ncbi Abnormal vestibular responses to vertical head motion in cerebellar ataxia
    Ke Liao
    Neurology Service and Daroff Dell Osso Laboratory, Veterans Affairs Medical Center, Cleveland, OH, USA
    Ann Neurol 64:224-7. 2008
    ..Impairment of the corresponding otolith-spinal reflexes may contribute substantially to falls...
  99. ncbi 3D eye movement analysis during sinusoidal off vertical axis rotation in human subjects
    Y Koizumi
    Department of Otolaryngology, Nippon Medical School, Tokyo, Japan
    Acta Otolaryngol 123:121-8. 2003
    ..In order to investigate these characteristics, we performed a 3D analysis of eye movements induced by human sinusoidal s-OVAR, and compared the result with that of eye movements induced by constant c-OVAR...
  100. ncbi Phase-plane analysis of gaze stabilization to high acceleration head thrusts: a continuum across normal subjects and patients with loss of vestibular function
    Grace C Y Peng
    Department of Neurology, The Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Neurophysiol 91:1763-81. 2004
    ..Similar patterns of challenge and compensation were observed in both patients with vestibular loss and normal subjects...
  101. ncbi The clinical utility of search coil horizontal vestibulo-ocular reflex testing
    Paul Kessler
    Otoneurology Laboratory, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Acta Otolaryngol 128:29-37. 2008
    ..It identifies high and low frequency/acceleration vestibular abnormalities that are frequently missed using other methods...

Research Grants67

  1. PHYSIOLOGY OF OCULOMOTOR PREMOTOR PATHWAYS
    Robert McCrea; Fiscal Year: 2007
    ..The results should increase our understanding of the central mechanisms that allow clear vision of objects in a 3D environment during passive and active head movements. ..
  2. Use of Optogenetics to Assess the Role of Climbing Fibers in Motor Learning
    Rhea R Kimpo; Fiscal Year: 2013
    ..abstract_text> ..
  3. Electrical Stimulation to Restore Three Dimensional Vestibular Sensation
    Charles C Della Santina; Fiscal Year: 2012
    ....
  4. CELLULAR SUBSTRATES OF CEREBELLAR INFORMATION STORAGE
    David J Linden; Fiscal Year: 2010
    ..In addition, they have potential clinical relevance for both cerebellar motor disorders and disorders of learning and memory generally...
  5. Vestibular control of head movements
    Natela M Shanidze; Fiscal Year: 2010
    ..This research will be instrumental in the development of novel approaches to clinical tests of inner ear dysfunction as well as its improved treatments. ..
  6. PHYSIOLOGY OF VESTIBULAR COMPENSATION
    Charles C Della Santina; Fiscal Year: 2013
    ....
  7. VESTIBULAR AND VISUAL CONTROL OF EYE MOVEMENT
    Jennifer L Raymond; Fiscal Year: 2013
    ..This improved understanding should facilitate the design of effective remediation strategies for disorders of learning and memory and rehabilitation strategies for CNS or peripheral injury. ..
  8. Behavioral and physiological studies of sound localization
    Tom C T Yin; Fiscal Year: 2013
    ..Defects in binaural function in human patients can lead to considerable difficulty in understanding conversations in a noisy room, which is the most common complaint of the hearing-impaired and can lead to severe social withdrawal. ..
  9. RECOVERY OF VESTIBULAR FUNCTION DURING REGENERATION
    J David Dickman; Fiscal Year: 2013
    ....
  10. Developmental Influences on the Functional Organization of the Vestibular System
    David Schoppik; Fiscal Year: 2013
    ..Further, they will fill specific technical and intellectual gaps, preparing me to successfully transition from a postdoctoral trainee to an independent investigator. ..
  11. Neural Activity in Guinea Pig Vestibular Nuclei During Volitional Head Movements
    William M King; Fiscal Year: 2013
    ....
  12. Studies of Three-Dimensional Ocular Kinematics
    Dora Angelaki; Fiscal Year: 2011
    ..Results from the proposed experiments are also fundamental in resolving on-going controversies and providing a comprehensive understanding of oculomotor function in health and disease. ..
  13. Vestibular Prosthesis Tested in a Vestibulopathic Model
    Richard F Lewis; Fiscal Year: 2012
    ..Successful completion of this task would significantly improve the quality of life for a large number of people who suffer from the debilitating symptoms produced by disorders of the balance portion of the inner ear. ..
  14. VESTIBULAR INFLUENCES ON SPATIAL ORIENTATION AND VISUOSPATIAL CONSTANCY
    Dora Angelaki; Fiscal Year: 2013
    ..Findings are important for understanding basic perceptual visual/vestibular interactions using quantitative methodology and opening new directions in the fields of basic and clinical spatial orientation psychophysics. ..
  15. Neural mechanisms of 3-D linear vestibuloocular reflex
    Chiju Chen Huang; Fiscal Year: 2009
    ..abstract_text> ..
  16. CELLULAR ANALYSIS OF THE VESTIBULO-OCULAR REFLEX
    Sascha du Lac; Fiscal Year: 2013
    ....
  17. Instructive Signals for Motor Learning
    Jennifer L Raymond; Fiscal Year: 2013
    ..An improved understanding of this process will inform the development of more effective interventions for a broad range of neurological and psychiatric disorders. ..
  18. Neural Basis of Gaze Shifts
    Neeraj J Gandhi; Fiscal Year: 2011
    ..Overall, the results of these experiments will provide insights into the neural control of gaze shifts and offer diagnostic value for deficits resulting from oculomotor, vestibular and cervical disorders. ..
  19. SYSTEMS ANALYSIS OF HEAD STABILIZATION
    Barry Peterson; Fiscal Year: 1999
    ....
  20. Vestibular Compensation During Volitional Head Movements
    SHAWN NEWLANDS; Fiscal Year: 2004
    ..This work is an extension and supplementation of the P.I.'s ongoing career development award project (K-08-DC00182). ..
  21. PLASTICITY IN THE VESTIBULOOCULAR REFLEXES & PERCEPTION
    SCOTT SEIDMAN; Fiscal Year: 2003
    ..The vestibulo ocular reflex (VOR) is an important vestibular mechanism that rotates the eyes to maintain binocular fixation on a ..
  22. VIEWING DISTANCE AND COMPENSATORY MOVEMENTS IN FALLS
    GEOFFREY BUSH; Fiscal Year: 2001
    ..abstract_text> ..
  23. RESEARCH AND TRAINING CENTER IN HEARING AND BALANCE
    Eric Young; Fiscal Year: 1999
    ....
  24. ANATOMICAL STUDIES OF CENTRAL VESTIBULAR ADAPTATION
    GAY HOLSTEIN; Fiscal Year: 1999
    ....
  25. Vestibular Hair Cell Regeneration
    LARRY HOFFMAN; Fiscal Year: 2007
    ..following four pharmaco-kinetically selected doses of GM; 2) Parallel measurements of the changes in the Vestibulo Ocular Reflex (VOR) function and of single vestibular nerve fibers physiological responses to be compared with the ..
  26. VESTIBULAR NUCLEUS ACTIVITY IN VESTIBULAR COMPENSATION
    SHAWN NEWLANDS; Fiscal Year: 2003
    ..abstract_text> ..
  27. Context-specific spatial adaptation of the VOR
    Sergei B Yakushin; Fiscal Year: 2011
    ..This could provide a new approach to explaining difficulties in balance and spatial orientation commonly encountered after lesions of the vestibular system. ..
  28. CLINICAL PREDICTORS FOR SUCCESSFUL VISUAL REHABILITATION
    FRANKLIN PORTER; Fiscal Year: 1992
    ..A predictive formula based on simple measurements in the low vision clinic will assist the clinician in prescribing telescopic spectacles and will improve rehabilitation strategies...
  29. NEURONAL INFORMATION STORAGE IN CEREBELLAR DEEP NUCLEI
    David Linden; Fiscal Year: 2004
    ..In addition, they have potential clinical relevance for both cerebellar motor disorders and disorders of learning and memory generally. ..
  30. ADAPTATION OF THE VOR TO MAXIMIZE GAIN CHANGES
    Erik Viirre; Fiscal Year: 2000
    ..In the proposed work here, we will test subjects after repeated exposures to successive increments in required VOR gain and determine if we can induce a persistent VOR gain change and a reduction in symptoms. ..
  31. SPATIAL ORIENTATION & PLASTICITY IN THE VESTIBULAR SYSTE
    Bernard Cohen; Fiscal Year: 2001
    ....
  32. ADAPTIVE CHANGES IN VESTIBULAR SYSTEM
    Werner Graf; Fiscal Year: 1991
    ....
  33. RESEARCH/TRAINING IN OCULAR MOTOR NEUROPHYSIOLOGY
    Helen Bronte Stewart; Fiscal Year: 1992
    ..Performing the experiment on several groups of cells should enable us to identify the site of motor learning the VOR...
  34. MORPHOLOGIC BASIS FOR CENTRAL VESTIBULAR INHIBITION
    GAY HOLSTEIN; Fiscal Year: 2002
    ....
  35. SENSING & CONTROLLING MOTION--VESTIBULAR & SENSORIMOTOR
    Bernard Cohen; Fiscal Year: 1991
    ..This four day conference will provide a comprehensive update on these areas. By emphasizing the latest work in the field, it should point toward new directions of future research...
  36. LONG TERM POTENTIATION AND DEPRESSION IN THE CEREBELLUM
    David Linden; Fiscal Year: 2002
    ..for certain forms of motor learning including associative eye blink conditioning and adaptation of the vestibulo ocular reflex. Recently, the converse phenomenon, cerebellar long-term potentiation (LTP) has also been described, in ..
  37. NEURONAL ORGANIZATION OF THE VESTIBULOOCULAR REF
    Barry Peterson; Fiscal Year: 2000
    ....
  38. Tracking Head Motion and Orientation in VOR Testing
    B Parker; Fiscal Year: 2004
    ..abstract_text> ..
  39. ROLE OF THE INFERIOR OLIVE IN VOR ADAPTATION
    Farrel Robinson; Fiscal Year: 1993
    ....
  40. SPATIAL COORDINATES OF VISUO VESTIBULO OCULAR REFLEXES
    ROBERT SOODAK; Fiscal Year: 1993
    ....
  41. REGENERATION & FUNCTIONAL RECOVERY IN NEURAL TISSUE
    Nigel Daw; Fiscal Year: 1990
    ....
  42. Role of multiple plasticity mechanisms in motor learning
    Edward Boyden; Fiscal Year: 2004
    ..rely upon pf-Pk LTD? 2) Do increases and decreases in VOR gain differentially rely upon pf-Pk LTP? 3) Do increases and decreases in VOR gain induce different patterns of gene expression in Purkinje cells, or elsewhere in the circuit? ..
  43. ADAPTIVE CAPABILITIES OF POSTURAL STABILIZING REFLEXES
    SUSAN HERDMAN; Fiscal Year: 1992
    ..The results of this project will be applied to the design and the assessment of physical therapy programs for patients with balance disorders...
  44. CELLULAR PHYSIOLOGY OF VESTIBULAR REFLEXES
    Barry Peterson; Fiscal Year: 2001
    ..Understanding of these reflexes is important since they are essential to maintain the clear vision and stable posture required to carry out many activities of daily living. ..
  45. Vestibular Adaptation and Compensatory Mechanisms
    Richard Clendaniel; Fiscal Year: 2005
    ..abstract_text> ..
  46. ADAPTATION OF LINEAR & ANGULAR VESTIBULOOCULAR REFLEXES
    Mark Shelhamer; Fiscal Year: 2000
    ....
  47. VESTIBULAR AFFERENT ACTIVITY AFTER CANAL PLUGGING
    Sergei Yakushin; Fiscal Year: 2002
    ..This work should lead to a clearer understanding of how lesions, such as plugging and nerve section, affect the sensory processing of head movements and how the central vestibular system adapts to these types of lesions. ..
  48. VOR adaptation/utility of saccades as rehab strategies
    Michael Schubert; Fiscal Year: 2008
    ..This is important for the long-term goals of this project, which are to determine the adaptive preferences that individuals with vestibular loss use to improve gaze stability. ..
  49. VESTIBULAR INFLUENCES ON SPATIAL ORIENTATION
    Richard Lewis; Fiscal Year: 2008
    ..abstract_text> ..
  50. Galvanic Effects on the Human Vestibuloocular Reflex
    Americo Migliaccio; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  51. Phase Transition Models of Oculomotor Control
    Mark Shelhamer; Fiscal Year: 2003
    ..The work represents a new direction for the PI because his past work has not dealt with the unique mathematical formulations required for this study. ..
  52. Pilot Studies in Adaptation in Parabolic Flight
    Mark Shelhamer; Fiscal Year: 2004
    ..abstract_text> ..
  53. Development of semicircular canal prostheses for studies of vestibular plasticity
    DANIEL MERFELD; Fiscal Year: 2009
    ..abstract_text> ..
  54. Adaptation to controlled vestibular stimulation
    DANIEL MERFELD; Fiscal Year: 2005
    ..All of these proposed specific aims will be investigated by measuring changes in the vestibulo-ocular responses induced by changes in chronic, patterned, electrical stimulation of the peripheral vestibular system. ..
  55. OCULOMOTOR SYSTEM AND BODY POSTURAL MECHANISMS
    Bernard Cohen; Fiscal Year: 2009
    ..abstract_text> ..
  56. Scaling in Reflexive and Volitional Eye Movements
    Mark Shelhamer; Fiscal Year: 2006
    ..Since scaling changes with pathology, new means to assess vestibular or oculomotor pathology may result. ..
  57. Improved Search Coil Method for Measuring Eye Movements
    Mark Shelhamer; Fiscal Year: 2007
    ..abstract_text> ..
  58. Vestibulocerebellar function in channelopathy mutants
    John Stahl; Fiscal Year: 2004
    ..Thus, the insights into normal cerebellar function generated by this study should also advance our understanding of mechanisms of heritable neurological disease. ..
  59. Long-term Ambulatory Gait Monitor for Parkinson's Disease
    Steven Moore; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  60. Motor Learning & Neural Plasticity in Vestibular System
    Wu Zhou; Fiscal Year: 2006
    ..This research will provide important knowledge for understanding the fundamental vestibular and oculomotor neurophysiology and improving the diagnosis and treatment of vestibular disorders in humans. ..
  61. NEURONAL PLASTICITY AND THE CONTROL OF EYE POSITION
    NEAL BARMACK; Fiscal Year: 2005
    ..We will use "differential display" to identify mRNAs in dorsal cap neurons whose proteins might be responsible for two functions: 1) Axonal transport of CRF , and 2) Calcium binding. ..
  62. Vestibular Recovery after Intratympanic Gentamicin
    John Carey; Fiscal Year: 2004
    ..Furthermore, the mechanisms of vestibular recovery may help us understand the potential for the inner ear to recover from a variety of injuries. ..
  63. NEURAL DECODING OF GRAVITO-INERTIAL CUES
    LIONEL ZUPAN; Fiscal Year: 2002
    ..It is important to note that the focus of our study is to understand the neural processing causing and underlying behavioral responses, not the eye movements per se. ..
  64. Evalution of Vestibular Function in Meniere's Disease
    John Carey; Fiscal Year: 2009
    ..Comparisons of angular and translational VOR deficits after intratympanic gentamicin should demonstrate whether or not the utricle is less susceptible than the semicircular canals to intratympanic gentamicin. ..
  65. RECOVERY OF DAMAGE TO THE VESTIBULAR-AUDITORY SYSTEM
    NEAL BARMACK; Fiscal Year: 2003
    ..abstract_text> ..
  66. VESTIBULAR EFFECTS OF INTRATYMPANIC GENTAMICIN
    John Carey; Fiscal Year: 2005
    ..Johns Hopkins is uniquely suited to this training because it has a core group devoted to vestibular research, and the mentor's laboratory has successfully used all of the techniques required. ..
  67. SENSORIMOTOR INTEGRATION IN HUMAN POSTURAL CONTROL
    Robert Peterka; Fiscal Year: 2009
    ..A better understanding of these active regulatory processes may lead to new rehabilitative methods and new clinical balance-function tests. ..