baroreflex

Summary

Summary: A response by the BARORECEPTORS to increased BLOOD PRESSURE. Increased pressure stretches BLOOD VESSELS which activates the baroreceptors in the vessel walls. The net response of the CENTRAL NERVOUS SYSTEM is a reduction of central sympathetic outflow. This reduces blood pressure both by decreasing peripheral VASCULAR RESISTANCE and by lowering CARDIAC OUTPUT. Because the baroreceptors are tonically active, the baroreflex can compensate rapidly for both increases and decreases in blood pressure.

Top Publications

  1. ncbi Exercise training improves arterial baro- and chemoreflex in control and diabetic rats
    Angela D Harthmann
    Hypertension Unit, Heart Institute InCor, University of Sao Paulo, Medical School, Av Eneas de Carvalho Aguiar 44, Sao Paulo, SP 05403 000, Brazil
    Auton Neurosci 133:115-20. 2007
  2. pmc Insulin enhances the gain of arterial baroreflex control of muscle sympathetic nerve activity in humans
    Colin N Young
    Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA
    J Physiol 588:3593-603. 2010
  3. ncbi Autonomic nervous function and baroreflex sensitivity in hypertensive diabetic patients
    Wei Ding
    Department of Endocrinology and Metabolism, Huashan Hospital of Fudan University, Shanghai, China
    Acta Cardiol 66:465-70. 2011
  4. ncbi Model-based assessment of baroreflex and cardiopulmonary couplings during graded head-up tilt
    Alberto Porta
    Department of Technologies for Health, Galeazzi Orthopedic Institute, University of Milan, Milan, Italy
    Comput Biol Med 42:298-305. 2012
  5. pmc Blood pressure variability and closed-loop baroreflex assessment in adolescent chronic fatigue syndrome during supine rest and orthostatic stress
    Vegard Bruun Wyller
    Department of Pediatrics, Rikshospitalet University Hospital, 0027, Oslo, Norway
    Eur J Appl Physiol 111:497-507. 2011
  6. ncbi Baroreflex sensitivity and heart rate variability in the identification of patients at risk for life-threatening arrhythmias: implications for clinical trials
    M T La Rovere
    Centro Medico di Montescano, Fondazione Salvatore Maugeri IRCCS, Pavia, Italy
    Circulation 103:2072-7. 2001
  7. ncbi Impaired autonomic function is associated with increased mortality, especially in subjects with diabetes, hypertension, or a history of cardiovascular disease: the Hoorn Study
    J Gerritsen
    Department of Clinical Physics and Informatics, Vrije Universiteit, Amsterdam, The Netherlands
    Diabetes Care 24:1793-8. 2001
  8. ncbi Exercise-induced increase in baroreflex sensitivity predicts improved prognosis after myocardial infarction
    Maria Teresa La Rovere
    Centro Medico di Montescano, Fondazione Salvatore Maugeri IRCCS, Montescano, Pavia, Italy
    Circulation 106:945-9. 2002
  9. ncbi Slow breathing reduces chemoreflex response to hypoxia and hypercapnia, and increases baroreflex sensitivity
    L Bernardi
    Department of Internal Medicine, University of Pavia and IRCCS Ospedale S Matteo, Pavia, Italy
    J Hypertens 19:2221-9. 2001
  10. ncbi Short-term oxygen administration restores blunted baroreflex sensitivity in patients with type 1 diabetes
    L Bernardi
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, University of Helsinki, Helsinki, Finland
    Diabetologia 54:2164-73. 2011

Detail Information

Publications339 found, 100 shown here

  1. ncbi Exercise training improves arterial baro- and chemoreflex in control and diabetic rats
    Angela D Harthmann
    Hypertension Unit, Heart Institute InCor, University of Sao Paulo, Medical School, Av Eneas de Carvalho Aguiar 44, Sao Paulo, SP 05403 000, Brazil
    Auton Neurosci 133:115-20. 2007
    ..Exercise training induced resting bradycardia (340+/-5 vs. 316+/-8 bpm) and improvement in baroreflex tachycardic response (3.4+/-0.31 vs. 2.7+/-0.06 bpm/mmHg in SC) and chemoreflex bradycardic (145+/-12 vs...
  2. pmc Insulin enhances the gain of arterial baroreflex control of muscle sympathetic nerve activity in humans
    Colin N Young
    Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA
    J Physiol 588:3593-603. 2010
    Recent animal studies indicate that insulin increases arterial baroreflex control of lumbar sympathetic nerve activity; however, the extent to which these findings can be extrapolated to humans is unknown...
  3. ncbi Autonomic nervous function and baroreflex sensitivity in hypertensive diabetic patients
    Wei Ding
    Department of Endocrinology and Metabolism, Huashan Hospital of Fudan University, Shanghai, China
    Acta Cardiol 66:465-70. 2011
    ..This study investigated cardiac autonomic nervous function in diabetic patients and controls with different grades of SBP...
  4. ncbi Model-based assessment of baroreflex and cardiopulmonary couplings during graded head-up tilt
    Alberto Porta
    Department of Technologies for Health, Galeazzi Orthopedic Institute, University of Milan, Milan, Italy
    Comput Biol Med 42:298-305. 2012
    We propose a multivariate dynamical adjustment (MDA) modeling approach to assess the strength of baroreflex and cardiopulmonary couplings from spontaneous cardiovascular variabilities...
  5. pmc Blood pressure variability and closed-loop baroreflex assessment in adolescent chronic fatigue syndrome during supine rest and orthostatic stress
    Vegard Bruun Wyller
    Department of Pediatrics, Rikshospitalet University Hospital, 0027, Oslo, Norway
    Eur J Appl Physiol 111:497-507. 2011
    ..The aim of this study was to explore blood pressure variability and closed-loop baroreflex function at rest and during mild orthostatic stress in adolescents with CFS...
  6. ncbi Baroreflex sensitivity and heart rate variability in the identification of patients at risk for life-threatening arrhythmias: implications for clinical trials
    M T La Rovere
    Centro Medico di Montescano, Fondazione Salvatore Maugeri IRCCS, Pavia, Italy
    Circulation 103:2072-7. 2001
    ..After Myocardial Infarctio (ATRAMI) demonstrated that markers of reduced vagal activity, such as depressed baroreflex sensitivity (BRS) an heart rate variability (HRV), are strong predictors of cardiac mortality after myocardial ..
  7. ncbi Impaired autonomic function is associated with increased mortality, especially in subjects with diabetes, hypertension, or a history of cardiovascular disease: the Hoorn Study
    J Gerritsen
    Department of Clinical Physics and Informatics, Vrije Universiteit, Amsterdam, The Netherlands
    Diabetes Care 24:1793-8. 2001
    OBJECTIVE: Measures of baroreflex sensitivity, heart rate variability (HRV), and the classical Ewing test parameters are currently used for the diagnosis of diabetic autonomic neuropathy and for mortality risk stratification after ..
  8. ncbi Exercise-induced increase in baroreflex sensitivity predicts improved prognosis after myocardial infarction
    Maria Teresa La Rovere
    Centro Medico di Montescano, Fondazione Salvatore Maugeri IRCCS, Montescano, Pavia, Italy
    Circulation 106:945-9. 2002
    ..Accordingly, we tested the hypothesis that exercise training, if accompanied by a shift toward increased vagal activity of an autonomic marker such as baroreflex sensitivity (BRS), could reduce mortality in post-MI patients.
  9. ncbi Slow breathing reduces chemoreflex response to hypoxia and hypercapnia, and increases baroreflex sensitivity
    L Bernardi
    Department of Internal Medicine, University of Pavia and IRCCS Ospedale S Matteo, Pavia, Italy
    J Hypertens 19:2221-9. 2001
    To investigate whether breathing more slowly modifies the sensitivity of the chemoreflex and baroreflex.
  10. ncbi Short-term oxygen administration restores blunted baroreflex sensitivity in patients with type 1 diabetes
    L Bernardi
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, University of Helsinki, Helsinki, Finland
    Diabetologia 54:2164-73. 2011
    We hypothesised that the blunted baroreflex sensitivity (BRS) typical of type 1 diabetes is caused by a higher degree of tissue hypoxia in diabetes, and tested whether oxygen increased BRS and ventilation less, equally or more than in ..
  11. ncbi Mathematical modeling of cardiovascular coupling: Central autonomic commands and baroreflex control
    Alessandro Silvani
    Department of Human and General Physiology, Alma Mater Studiorum Universita di Bologna, Piazza di Porta San Donato 2, Bologna, Italy
    Auton Neurosci 162:66-71. 2011
    ..These patterns may result from the baroreflex and central autonomic commands (CAC), respectively...
  12. ncbi Central arterial compliance is associated with age- and habitual exercise-related differences in cardiovagal baroreflex sensitivity
    K D Monahan
    Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, Denver, USA
    Circulation 104:1627-32. 2001
    Background- Cardiovagal baroreflex sensitivity (BRS) declines with age but is favorably modulated by habitual aerobic exercise...
  13. ncbi Baroreflex sensitivity predicts long-term cardiovascular mortality after myocardial infarction even in patients with preserved left ventricular function
    Gaetano M De Ferrari
    Department of Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    J Am Coll Cardiol 50:2285-90. 2007
    This study sought to assess the long-term predictive power of depressed baroreflex sensitivity (BRS) among post-myocardial infarction (MI) patients with preserved left ventricular function.
  14. ncbi A study of orthostatic hypotension, heart rate variability and baroreflex sensitivity in late-life depression
    Akshya Vasudev
    Institute for Ageing and Health, Newcastle University, UK
    J Affect Disord 131:374-8. 2011
    To determine if subjects with late-life depression have significant cardiovascular autonomic abnormalities (orthostatic blood pressure drop, heart rate variability and baroreflex sensitivity).
  15. ncbi Cardiac and peripheral adjustments induced by early exercise training intervention were associated with autonomic improvement in infarcted rats: role in functional capacity and mortality
    Luciana Jorge
    Hypertension Unit, Heart Institute InCor, Medical School of University of São Paulo, Av Dr Eneas de Carvalho Aguiar 44 Subsolo, Sao Paulo, SP, Brazil
    Eur Heart J 32:904-12. 2011
    ..To test the effects of early exercise training (ET) on left ventricular (LV) and autonomic functions, haemodynamics, tissues blood flows (BFs), maximal oxygen consumption (VO(2) max), and mortality after myocardial infarction (MI) in rats...
  16. ncbi Selective norepinephrine reuptake inhibition as a human model of orthostatic intolerance
    Christoph Schroeder
    Clinical Research Center, Helios Klinkum Berlin, Germany
    Circulation 105:347-53. 2002
    ..Observations in patients with functional mutations of the norepinephrine transporter (NET) gene suggest that impaired norepinephrine uptake may contribute to idiopathic orthostatic intolerance...
  17. ncbi Strength training does not affect vagal-cardiac control or cardiovagal baroreflex sensitivity in young healthy subjects
    William H Cooke
    U S Army Institute of Surgical Research, 3400 Rawley E Chambers Ave Bld 3611, Fort Sam Houston, Texas 78234 6315, USA
    Eur J Appl Physiol 93:719-25. 2005
    ..was to test the hypothesis that high-intensity strength training increases vagal-cardiac control and cardiovagal baroreflex sensitivity. Twenty-two subjects [age 22 (0...
  18. ncbi Quercetin improves baroreflex sensitivity in spontaneously hypertensive rats
    Matheus M O Monteiro
    Biotechnology Center, Federal University of Paraiba, Joao Pessoa, Brazil
    Molecules 17:12997-3008. 2012
    ..we investigated the effects of treatment with quercetin on mean arterial pressure (MAP), heart rate (HR) and baroreflex sensitivity (BRS) in spontaneously hypertensive rats (SHR)...
  19. ncbi Involvement of acetylcholine-α7nAChR in the protective effects of arterial baroreflex against ischemic stroke
    Ai jun Liu
    Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai, China
    CNS Neurosci Ther 18:918-26. 2012
    Decreased baroreflex sensitivity is associated with poor outcome in many cardiovascular diseases including stroke, but the molecular mechanism underlying this relationship is unclear...
  20. ncbi Four faces of baroreflex failure: hypertensive crisis, volatile hypertension, orthostatic tachycardia, and malignant vagotonia
    Terry Ketch
    Autonomic Dysfunction Center, Vanderbilt University, Nashville, TN 37232 2195, USA
    Circulation 105:2518-23. 2002
    The baroreflex normally serves to buffer blood pressure against excessive rise or fall. Baroreflex failure occurs when afferent baroreceptive nerves or their central connections become impaired...
  21. ncbi Treatment by n-acetylcysteine and melatonin increases cardiac baroreflex and improves antioxidant reserve
    Helene Girouard
    Research Group on Autonomic Nervous System, Department of Physiology, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada
    Am J Hypertens 17:947-54. 2004
    The aims of this study were to investigate the effects of melatonin and n-acetylcysteine on the baroreflex sensitivity and to verify whether those effects were correlated with their antioxidant capacity in Wistar-Kyoto and spontaneously ..
  22. ncbi Spontaneous baroreflex sensitivity: prospective validation trial of a novel technique in survivors of acute myocardial infarction
    Petra Barthel
    Medizinische Klinik und Deutsches Herzzentrum München der Technischen Universität München, Munich, Germany
    Heart Rhythm 9:1288-94. 2012
    Low baroreflex sensitivity (BRS) indicates poor prognosis after acute myocardial infarction. Noninvasive BRS assessment is complicated by nonstationarities and noise in electrocardiogram and pressure signals...
  23. pmc Supine low-frequency power of heart rate variability reflects baroreflex function, not cardiac sympathetic innervation
    Jeffrey P Moak
    Children s National Medical Center, Washington, DC, USA
    Heart Rhythm 4:1523-9. 2007
    ..Alternatively, LF power might reflect baroreflexive modulation of autonomic outflows...
  24. pmc Sidestream cigarette smoke effects on cardiovascular responses in conscious rats: involvement of oxidative stress in the fourth cerebral ventricle
    Vitor E Valenti
    Programa de Pós graduação em Fisioterapia, Faculdade de Ciencias e Tecnologia, Universidade Estadual Paulista, UNESP, Presidente Prudente, SP, Brazil
    BMC Cardiovasc Disord 12:22. 2012
    ..We aimed to evaluate the effects of central catalase inhibition on baroreflex and cardiovascular responses in rats exposed to sidestream cigarette smoke (SSCS).
  25. pmc Identifying physiological origins of baroreflex dysfunction in salt-sensitive hypertension in the Dahl SS rat
    Scott M Bugenhagen
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 42:23-41. 2010
    Salt-sensitive hypertension is known to be associated with dysfunction of the baroreflex control system in the Dahl salt-sensitive (SS) rat...
  26. pmc Baroreflex gain in children with obstructive sleep apnea
    Keith McConnell
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Am J Respir Crit Care Med 180:42-8. 2009
    ..The baroreflex system buffers blood pressure changes by varying heart rate...
  27. ncbi Arterial baroreflex control of the peripheral vasculature in humans: rest and exercise
    Paul J Fadel
    Department of Medical Pharmacology and Physiology, Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO 65212, USA
    Med Sci Sports Exerc 40:2055-62. 2008
    ..There is now ample evidence to indicate that the arterial baroreflex remains functional during exercise by resetting in direct relation to the intensity of exercise from rest to ..
  28. ncbi Baroreflex control of muscle sympathetic nerve activity in postural orthostatic tachycardia syndrome
    N Muenter Swift
    Department of Neurology Autonomic Disorders Center, Mayo Clinic, 200 First St SW, Charlton 7 271A, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 289:H1226-33. 2005
    ..To test the hypothesis that patients with POTS have decreased sympathetic neural responses to baroreflex stimuli, we measured heart rate (HR) and muscle sympathetic nerve activity (MSNA) responses to three baroreflex ..
  29. ncbi Effects of sidestream cigarette smoke exposure on baroreflex components in spontaneously hypertensive rats
    Vitor E Valenti
    Departamento de Medicina, Disciplina de Cardiologia, Universidade Federal de Sao Paulo UNIFESP, Sao Paulo, Brazil
    Int J Environ Health Res 20:431-7. 2010
    We evaluated short-term effects of sidestream cigarette smoke (SSCS) exposure on baroreflex function in spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) normotensive rats...
  30. ncbi The human sympathetic nervous system: its relevance in hypertension and heart failure
    Gianfranco Parati
    Department of Cardiology, S Luca Hospital, IRCCS Istituto Auxologico Italiano, piazza Brescia 20, 20149 Milan, Italy
    Eur Heart J 33:1058-66. 2012
    ....
  31. pmc Relationship between sympathetic baroreflex sensitivity and arterial stiffness in elderly men and women
    Yoshiyuki Okada
    Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, TX 75231, USA
    Hypertension 59:98-104. 2012
    ..human studies have shown that large-artery stiffness contributes to an age-related decrease in cardiovagal baroreflex sensitivity. Whether this is also true with sympathetic baroreflex sensitivity is unknown...
  32. ncbi Novel mechanisms of sympathetic regulation in chronic heart failure
    Irving H Zucker
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Hypertension 48:1005-11. 2006
  33. ncbi Cardiovascular autonomic imbalance and baroreflex dysfunction in the apolipoprotein E-deficient mouse
    Elisardo C Vasquez
    Department of Physiological Sciences, Health Sciences Center, Federal University of Espirito Santo, Vitoria, ES, Brazil
    Cell Physiol Biochem 29:635-46. 2012
    ..and sympathetic nervous systems controlling heart rate and blood pressure and emphasize the dysfunction of the baroreflex control of cardiovascular function and how this dysfunction is influenced by nitric oxide, reactive oxygen ..
  34. ncbi Prognostic implications of baroreflex sensitivity in heart failure patients in the beta-blocking era
    Maria Teresa La Rovere
    Divisione di Cardiologia, e Bioingegneria, Fondazione Salvatore Maugeri, IRCCS Istituto Scientifico di Montescano, Montescano, Italy
    J Am Coll Cardiol 53:193-9. 2009
    ..This study investigated the clinical correlates and prognostic value of depressed baroreceptor-heart rate reflex sensitivity (BRS) among patients with heart failure (HF), with and without beta-blockade...
  35. ncbi How to measure baroreflex sensitivity: from the cardiovascular laboratory to daily life
    G Parati
    Istituto Scientifico Ospedale S Luca, Istituto Auxologico Italiano, Milan
    J Hypertens 18:7-19. 2000
    Arterial baroreflex function in humans is commonly assessed through a number of laboratory tests based on quantification of the reflex responses in heart rate or blood pressure to external stimuli applied to the cardiovascular system...
  36. ncbi Slow breathing increases arterial baroreflex sensitivity in patients with chronic heart failure
    Luciano Bernardi
    Department of Internal Medicine, University of Pavia and IRCCS Ospedale S Matteo, Pavia, Italy
    Circulation 105:143-5. 2002
    It is well established that a depressed baroreflex sensitivity may adversely influence the prognosis in patients with chronic heart failure (CHF) and in those with previous myocardial infarction.
  37. ncbi Point: cardiovascular variability is/is not an index of autonomic control of circulation
    Gianfranco Parati
    Department of Clinical Medicine Prevention and Applied Biotechnology University of Milano Bicocca Milan, Italy
    J Appl Physiol 101:676-8; discussion 681-2. 2006
  38. ncbi Potentiation of baroreceptor reflex response by heat shock protein 70 in nucleus tractus solitarii confers cardiovascular protection during heatstroke
    P L Li
    Department of Biological Science and Center for Neuroscience, National Sun Yat-Sen University, Taiwan, Republic of China
    Circulation 103:2114-9. 2001
    ....
  39. ncbi A "love triangle" elicited by electrochemistry: complex interactions among cardiac sympathetic afferent, chemo-, and baroreflexes
    Yan hua Du
    J Appl Physiol 102:9-10. 2007
  40. ncbi Novel baroreflex activation therapy in resistant hypertension: results of a European multi-center feasibility study
    Ingrid J M Scheffers
    University Hospital Maastricht and Cardiovascular Research Institute Maastricht CARIM, Maastricht, The Netherlands
    J Am Coll Cardiol 56:1254-8. 2010
    ..This study assessed the safety and efficacy of a novel implantable device therapy in resistant hypertension patients...
  41. ncbi Slow breathing improves arterial baroreflex sensitivity and decreases blood pressure in essential hypertension
    Chacko N Joseph
    Department of Internal Medicine, University of Pavia, IRCCS Ospedale S Matteo, Pavia, Italy
    Hypertension 46:714-8. 2005
    ..This autonomic imbalance is in turn related to a reduced or reset arterial baroreflex sensitivity and chemoreflex-induced hyperventilation...
  42. ncbi Carotid baroreceptor stimulation, sympathetic activity, baroreflex function, and blood pressure in hypertensive patients
    Karsten Heusser
    Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany
    Hypertension 55:619-26. 2010
    ..Furthermore, we tested whether the stimulation impairs the physiological baroreflex regulation. We studied 7 men and 5 women (ages 43 to 69 years) with treatment-resistant arterial hypertension...
  43. ncbi Angiotensin peptides and baroreflex control of sympathetic outflow: pathways and mechanisms of the medulla oblongata
    D B Averill
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Brain Res Bull 51:119-28. 2000
    ..Emphasis is placed on the probable components and neural mechanisms of the medullary baroreflex arc that account for the ability of angiotensin peptides to change the sensitivity of the baroreceptor reflex ..
  44. pmc Mechanisms of inhaled fine particulate air pollution-induced arterial blood pressure changes
    Carlo R Bartoli
    Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, and Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Environ Health Perspect 117:361-6. 2009
    ..Epidemiologic studies suggest a positive association between fine particulate matter and arterial blood pressure, but the results have been inconsistent...
  45. pmc Brain renin-angiotensin system dysfunction in hypertension: recent advances and perspectives
    Shereeni J Veerasingham
    Department of Physiology and Functional Genomics, University of Florida, USA
    Br J Pharmacol 139:191-202. 2003
    ..hypertension are not well understood but include increases in sympathetic vasomotor tone and impaired arterial baroreflex function...
  46. pmc Angiotensin II type 1 receptor-mediated reduction of angiotensin-converting enzyme 2 activity in the brain impairs baroreflex function in hypertensive mice
    Huijing Xia
    Louisiana State University Health Sciences Center, School of Medicine, Department of Pharmacology and Experimental Therapeutics, 1901 Perdido St, P7 1, New Orleans, LA 70112, USA
    Hypertension 53:210-6. 2009
    ..central angiotensin II type 1 receptors reduce ACE2 expression/activity in hypertensive mice, thereby impairing baroreflex function and promoting hypertension...
  47. ncbi Effect of central and peripheral body fat distribution on sympathetic and baroreflex function in obese normotensives
    Guido Grassi
    Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Universita di Milano Bicocca, Milano, Italy
    J Hypertens 22:2363-9. 2004
    ..shown that obesity is characterized by a sympathetic overactivity coupled with an insulin resistance state and a baroreflex impairment...
  48. ncbi Exercise training normalizes sympathetic outflow by central antioxidant mechanisms in rabbits with pacing-induced chronic heart failure
    Lie Gao
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Circulation 115:3095-102. 2007
    ..In the present study, we therefore hypothesized that long-term exercise exerts its beneficial effect on autonomic activity in CHF via central antioxidative mechanisms...
  49. ncbi Continuous positive airway pressure treatment improves baroreflex control of heart rate during sleep in severe obstructive sleep apnea syndrome
    Maria R Bonsignore
    Institute of Respiratory Physiology, Italian National Research Council, Via Ugo La Malfa, 153 90146 Palermo, Italy
    Am J Respir Crit Care Med 166:279-86. 2002
    The role of the arterial baroreflex in the cardiovascular changes associated with the obstructive sleep apnea syndrome (OSAS), and the effect of nasal continuous positive airway pressure (CPAP) treatment on baroreflex function during ..
  50. ncbi Differential modulation of leptin-induced sympathoexcitation by baroreflex activation
    Martin Hausberg
    Department of Internal Medicine D, University of Munster, Munster, Germany
    J Hypertens 20:1633-41. 2002
    ..The aim of the present study was to test the hypothesis that the increases in sympathetic nerve activity induced by leptin in different regions respond differentially to baroreflex activation.
  51. ncbi Inhibitory neurotransmission in the nucleus tractus solitarii: implications for baroreflex resetting during exercise
    Jeffrey T Potts
    Department of Biomedical Science, Dalton Cardiovascular Research Center, University of Missouri Columbia, Columbia, MO 65211, USA
    Exp Physiol 91:59-72. 2006
    ..review is to provide a critical overview of inhibitory mechanisms that may be responsible for altering arterial baroreflex function during physical activity or exercise...
  52. ncbi Effect of long-acting testosterone treatment on functional exercise capacity, skeletal muscle performance, insulin resistance, and baroreflex sensitivity in elderly patients with chronic heart failure a double-blind, placebo-controlled, randomized study
    Giuseppe Caminiti
    Centre for Clinical and Basic Research, Cardiovascular Research Unit, Department of Medical Sciences, IRCCS San Raffaele Pisana, Rome, Italy
    J Am Coll Cardiol 54:919-27. 2009
    ..effect of a 12-week long-acting testosterone administration on maximal exercise capacity, ventilatory efficiency, muscle strength, insulin resistance, and baroreflex sensitivity (BRS) in elderly patients with chronic heart failure (CHF).
  53. ncbi Orexin neuron-mediated skeletal muscle vasodilation and shift of baroreflex during defense response in mice
    Wei Zhang
    Department of Molecular and Integrative Physiology, Chiba University Graduate School of Medicine, 1 8 1 Chuo ku, Chiba 260 8670, Japan
    Am J Physiol Regul Integr Comp Physiol 290:R1654-63. 2006
    ..166+/-26 during stimulation) in WT. This demonstrated the resetting of the baroreflex. In ORX/ATX-Tg mice, however, no significant suppression was observed (-355+/-16 without stimulation vs...
  54. ncbi Evaluation of baroreflex control of heart rate in renovascular hypertensive mice
    Veronica A Peotta
    Laboratory of Transgenes and Cardiovascular Control, Physiological Sciences Graduate Program, Health Sciences Center, Federal University of Espirito Santo, Avenida Marechal Campos 1468, Vitoria, ES 29042 755, Brazil
    Can J Physiol Pharmacol 85:761-6. 2007
    The objective of the present study was to evaluate the baroreflex and the autonomic control of heart rate (HR) in renovascular hypertensive mice...
  55. ncbi Spontaneous respiratory modulation improves cardiovascular control in essential hypertension
    Carlos Hermano da Justa Pinheiro
    Laboratório de Cardiopneumologia e Fisiologia do Exercício, Escola de Saúde Pública do Estado do Ceará, Universidade de Fortaleza, Fortaleza, CE, Brasil
    Arq Bras Cardiol 88:651-9. 2007
    Recent studies show that controlled breathing improves baroreflex and heart rate variability and lowers blood pressure in hypertensive patients.
  56. ncbi Physiological sleep-dependent changes in arterial blood pressure: central autonomic commands and baroreflex control
    Alessandro Silvani
    Department of Human and General Physiology, University of Bologna, Bologna, Italy
    Clin Exp Pharmacol Physiol 35:987-94. 2008
    ....
  57. ncbi Effects of magnesium sulfate on heart rate, blood pressure variability and baroreflex sensitivity in preeclamptic rats treated with L-NAME
    Qiongjie Zhou
    Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China
    Hypertens Pregnancy 32:422-31. 2013
    ..This study aimed to evaluate effects of magnesium sulfate on heart rate variability (HRV), blood pressure variability (BPV) and baroreflex sensitivity (BRS) in pregnant rats treated with N(G)-nitro-.-arginine-methyl ester (L-NAME).
  58. ncbi Cardiac baroreflex control in humans during and immediately after brief exposure to simulated high altitude
    Frederic Roche
    Laboratoire de Physiologie GIP E2S, PPEH, Service d Exploration Fonctionnelle CardioRespiratoire, CHU Nord, Faculte de Medecine Jacques Lisfranc, Université Jean Monnet, Saint Etienne, France
    Clin Physiol Funct Imaging 22:301-6. 2002
    To examine the baroreflex response in humans during and immediately after acute hypoxia exposure, the cardiac baroreflex sensitivity (BRS) was studied using adaptation of RR intervals in response to spontaneous systolic blood pressure ..
  59. ncbi Continuous positive airway pressure improves daytime baroreflex sensitivity and nitric oxide production in patients with moderate to severe obstructive sleep apnea syndrome
    Akiko Noda
    Nagoya University School of Health Sciences, Nagoya, Japan
    Hypertens Res 30:669-76. 2007
    ..The effects of OSAS severity and nocturnal continuous positive airway pressure (CPAP) on daytime baroreflex sensitivity (BRS) and nitric oxide (NO) production were investigated in OSAS patients...
  60. ncbi Baroreflex function in hypertension: consequences for antihypertensive therapy
    Guido Grassi
    Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Ospedale San Gerardo dei Tintori, Universita Milano Bicocca, Via Pergolesi 33, 20052 Monza, Milan, Italy
    Prog Cardiovasc Dis 48:407-15. 2006
    ..This review will examine the main features of cardiovascular reflex control in hypertension and the effects of the different classes of antihypertensive drugs in uncomplicated and complicated hypertension...
  61. ncbi The cold face test: a non-baroreflex mediated test of cardiac vagal function
    Ramesh K Khurana
    The Union Memorial Hospital, 201 East University Parkway Room 411, 33rd Street Professional Building, Baltimore, MD 21218, USA
    Clin Auton Res 16:202-7. 2006
    ..However, the role of the baroreceptors in this response is unclear. Ten healthy controls and two patients with baroreflex impairment were recruited. A cold face test (CFT) was induced by the application of three cold packs (0...
  62. ncbi Baroreflex deficit blunts exercise training-induced cardiovascular and autonomic adaptations in hypertensive rats
    I C Moraes-Silva
    Experimental Hypertension Laboratory, Hypertension Unit, Heart Institute, Sao Paulo, Brazil
    Clin Exp Pharmacol Physiol 37:e114-20. 2010
    ..BPV) and sympathetic activity, whereas exercise training has been associated with an improvement in these baroreflex-mediated changes...
  63. ncbi Exercise training associated with estrogen therapy induced cardiovascular benefits after ovarian hormones deprivation
    Karin Flues
    Hypertension Unit, Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Maturitas 65:267-71. 2010
    ..Trained groups were submitted to an 8-week exercise training protocol on treadmill. Baroreflex sensitivity (BRS) was evaluated by heart rate responses to arterial pressure (AP) changes, and vagal and ..
  64. ncbi Autonomic activity and baroreflex sensitivity in patients submitted to carotid stenting
    Maurizio Acampa
    Stroke Unit, Department of Emergency, Hospital of Siena, Siena, Italy
    Neurosci Lett 491:221-6. 2011
    Arterial baroreflex and cardiac autonomic control play important roles in hemodynamic instability after carotid artery stenting (CAS)...
  65. pmc Chronic electrical stimulation of the carotid sinus baroreflex improves left ventricular function and promotes reversal of ventricular remodeling in dogs with advanced heart failure
    Hani N Sabbah
    Department of Medicine, Division of Cardiovascular Medicine, Henry Ford Heart and Vascular Institute, 2799 W Grand Blvd, Detroit, MI 48202, USA
    Circ Heart Fail 4:65-70. 2011
    ..Activation of the carotid sinus baroreflex (CSB) has been shown to reduce sympathetic outflow and augment parasympathetic vagal tone...
  66. ncbi Central N-acetylcysteine effects on baroreflex in juvenile spontaneously hypertensive rats
    Vitor E Valenti
    Departamento de Medicina, Disciplina de Cardiologia, Universidade Federal de Sao Paulo UNIFESP, Brazil
    J Integr Neurosci 10:161-76. 2011
    In this study, we evaluated the acute effects of central NAC administration on baroreflex in juvenile SHR and Wistar Kyoto (WKY) rats...
  67. pmc Afferent baroreflex failure in familial dysautonomia
    Lucy Norcliffe-Kaufmann
    Dysautonomia Center, New York University School of Medicine, New York, NY, USA
    Neurology 75:1904-11. 2010
    Familial dysautonomia (FD) is due to a genetic deficiency of the protein IKAP, which affects development of peripheral neurons. Patients with FD display complex abnormalities of the baroreflex of unknown cause.
  68. ncbi Comparison of the prognostic values of invasive and noninvasive assessments of baroreflex sensitivity in heart failure
    Maria T La Rovere
    Department of Cardiology, S Maugeri Foundation, IRCCS Scientific Institute of Montescano, Montescano, Pavia, Italy
    J Hypertens 29:1546-52. 2011
    No studies have compared the prognostic values of invasive (phenylephrine, Phe) and noninvasive (transfer function) assessments of baroreflex sensitivity (BRS).
  69. ncbi Cardiovascular response to dynamic aerobic exercise: a mathematical model
    E Magosso
    Department of Electronics, Computer Science and Systems, University of Bologna, Bologna, Italy
    Med Biol Eng Comput 40:660-74. 2002
    ..These mechanisms embrace the so-called central command, the arterial baroreflex and the lung inflation reflex...
  70. ncbi Reproducibility of methods for assessing baroreflex sensitivity in normal controls and in patients with chronic heart failure
    L C Davies
    National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, London, U K
    Clin Sci (Lond) 97:515-22. 1999
    b>Baroreflex sensitivity (BRS) conveys useful prognostic information in patients with heart disease, yet methods for its quantification suffer from poor reproducibility and test failure in some patients with heart failure...
  71. pmc Brain systems for baroreflex suppression during stress in humans
    Peter J Gianaros
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Hum Brain Mapp 33:1700-16. 2012
    The arterial baroreflex is a key mechanism for the homeostatic control of blood pressure (BP)...
  72. ncbi Central antioxidant therapy inhibits parasympathetic baroreflex control in conscious rats
    Marcelo Franchini Giusti
    Department of Physiology, School of Medicine of ABC, Santo Andre, SP, Brazil
    Neurosci Lett 489:115-8. 2011
    ..ascorbic acid (AAC) and N-acetylcysteine (NAC) injections into the 4thV on the parasympathetic component of the baroreflex. Male Wistar rats were implanted with a stainless steel guide cannula into the 4thV...
  73. pmc Insulin acts in the arcuate nucleus to increase lumbar sympathetic nerve activity and baroreflex function in rats
    Priscila A Cassaglia
    Oregon Health and Science University, 1381 SW Sam Jackson Park Road L334, Portland, OR 97239, USA
    J Physiol 589:1643-62. 2011
    Although the central effects of insulin to activate the sympathetic nervous system and enhance baroreflex gain are well known, the specific brain site(s) at which insulin acts has not been identified...
  74. ncbi Effects of whole body heating on dynamic baroreflex regulation of heart rate in humans
    C G Crandall
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas 75231, USA
    Am J Physiol Heart Circ Physiol 279:H2486-92. 2000
    The purpose of this project was to identify whether dynamic baroreflex regulation of heart rate (HR) is altered during whole body heating. In 14 subjects, dynamic baroreflex regulation of HR was assessed using transfer function analysis...
  75. ncbi Effects of exercise training on baroreflex control of the cardiovascular system
    E M Krieger
    Unidade de Hipertensao, InCor Instituto do Coração da Faculdade de Medicina da Universidade de São Paulo, Av Dr Eneas de Carvalho Aguiar, 44, Sao Paulo, Brazil, 05403 000
    Ann N Y Acad Sci 940:338-47. 2001
    ..mediated by improving the depressed baroreceptor function, which is, in part, responsible for the attenuation of the baroreflex sensitivity observed in the sedentary SHR (Krieger et al., 1998, 1999; see references 4 and 5 in the paper).
  76. ncbi Walking promotes metabolic and baroreflex sensitivity improvement in fructose-fed male rats
    Jacqueline F Machi
    Hypertension Unit, Heart Institute InCor, University of Sao Paulo, Medical School, Av Dr Eneas de Carvalho Aguiar, 44, Sao Paulo 05403 900, Brazil
    Eur J Appl Physiol 113:41-9. 2013
    ..Arterial pressure (AP) signals were directly recorded. Baroreflex sensitivity (BR) was evaluated by the reflex tachycardia (TR) and bradycardia (BR) to AP changes...
  77. pmc Central Rho kinase inhibition restores baroreflex sensitivity and angiotensin II type 1 receptor protein imbalance in conscious rabbits with chronic heart failure
    Karla K V Haack
    Nebraska Medical Center, Omaha, NE, USA
    Hypertension 61:723-9. 2013
    ..Arterial baroreflex control was assessed by intravenous infusion of sodium nitroprusside and phenylephrine...
  78. ncbi Effect of acute traumatic brain injury on baroreflex function
    C Geraldine McMahon
    Emergency Medicine, Trinity College Dublin, St James s Hospital, Dublin 8, Ireland
    Shock 35:53-8. 2011
    The integrity of the arterial baroreflex is central to cardiovascular homeostasis. There is evidence of altered cardiovascular regulation after acute traumatic brain injury (TBI)...
  79. ncbi Time versus frequency domain techniques for assessing baroreflex sensitivity
    P B Persson
    Johannes Müller Institut für Physiologie, Berlin, Germany
    J Hypertens 19:1699-705. 2001
    Newer techniques to evaluate baroreflex sensitivity (BRS) are based on the analysis of blood pressure (BP) and heart rate (HR) time series in the time or frequency domain...
  80. ncbi Reduced autonomic activity during stepwise exposure to high altitude
    K Sevre
    Department of Cardiology, , Oslo, Norway
    Acta Physiol Scand 173:409-17. 2001
    ..1 +/- 6%, P = 0.03). Diastolic blood pressure, HR and adrenaline displayed similar tendencies. We conclude that a transient reduction in parasympathetic and sympathetic activity was demonstrated during stepwise exposure to high altitude...
  81. ncbi N-methyl-D-aspartate glutamate receptors in the hypothalamic paraventricular nucleus modulate cardiac component of the baroreflex in unanesthetized rats
    Carlos C Crestani
    Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes 3900, Ribeirao Preto, SP, 14049 900, Brazil
    Neurosci Res 67:317-26. 2010
    ..we investigated the role played by the hypothalamic paraventricular nucleus (PVN) in the modulation of cardiac baroreflex activity in unanesthetized rats...
  82. pmc Modulation of arterial baroreflex dynamic response during mild orthostatic stress in humans
    Masashi Ichinose
    Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba City, Ibaraki, 305 8574, Japan
    J Physiol 557:321-30. 2004
    We tested the hypothesis that in humans, carotid-baroreflex dynamic responses (evaluated by examining the time course of the carotid-baroreflex-induced alterations in muscle sympathetic nerve activity (MSNA), mean arterial blood pressure (..
  83. pmc Hysteresis in the sympathetic baroreflex: role of baseline nerve activity
    Emma C Hart
    Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 59906, USA
    J Physiol 589:3395-404. 2011
    Sympathetic baroreflex sensitivity (BRS) is greater during decreasing compared to increasing diastolic blood pressure (DBP) in young men and women...
  84. pmc Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase
    Pal Pacher
    National Institutes of Health, NIAAA, Laboratory of Physiological Studies, 5625 Fishers Lane MSC 9413, Rm 2S24, Bethesda, MD 20892 9413, USA
    Am J Physiol Heart Circ Physiol 289:H533-41. 2005
    ..Baseline cardiovascular parameters, systolic and diastolic function at different preloads, and baroreflex sensitivity were similar in FAAH-/- and FAAH+/+ mice...
  85. ncbi Carotid baroreflex regulation of sympathetic nerve activity during dynamic exercise in humans
    P J Fadel
    Department of Integrative Physiology and Cardiovascular Research Institute, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    Am J Physiol Heart Circ Physiol 280:H1383-90. 2001
    We sought to determine whether carotid baroreflex (CBR) control of muscle sympathetic nerve activity (MSNA) was altered during dynamic exercise. In five men and three women, 23.8 +/- 0...
  86. pmc Peripheral chemoreflex and baroreflex interactions in cardiovascular regulation in humans
    John R Halliwill
    Department of Exercise and Movement Science, University of Oregon, 122 Esslinger Hall, Eugene, OR 97403 1240, USA
    J Physiol 552:295-302. 2003
    ..We tested the hypothesis that activation of peripheral chemoreceptors with acute isocapnic hypoxia resets arterial baroreflex control of both heart rate and sympathetic vasoconstrictor outflow to higher pressures, resulting in increased ..
  87. ncbi Impaired baroreflex function during pregnancy is associated with stiffening of the carotid artery
    Z Visontai
    Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary
    Ultrasound Obstet Gynecol 20:364-9. 2002
    The baroreflex sensitivity and the distensibility of the carotid artery were measured during normotensive pregnancy to test the hypothesis that changes in baroreflex sensitivity are related to carotid artery stiffening.
  88. pmc Low frequency power of heart rate variability reflects baroreflex function, not cardiac sympathetic innervation
    Faisal Rahman
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive MSC 1620, Bethesda, MD 20892 1620, USA
    Clin Auton Res 21:133-41. 2011
    ..We reported previously that LF power may reflect baroreflex modulation...
  89. ncbi Influence of increased central venous pressure on baroreflex control of sympathetic activity in humans
    N Charkoudian
    Dept of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 287:H1658-62. 2004
    ..ameliorates symptoms of orthostatic intolerance; however, the influence of this increased volume on integrated baroreflex control of vascular sympathetic activity is unknown...
  90. ncbi Regular endurance exercise in young men increases arterial baroreflex sensitivity through neural alteration of baroreflex arc
    Hidehiko Komine
    Institute for Human Science and Biomedical Engineering, National Institute of Advanced Industrial Science and Technology AIST Higashi 1 1 1, Tsukuba, Ibaraki 305 8566, Japan
    J Appl Physiol (1985) 106:1499-505. 2009
    Endurance exercise training increases arterial baroreflex sensitivity that corresponds to alteration in vessel wall compliance of the carotid artery in elderly men...
  91. pmc Sex differences in baroreflex sensitivity, heart rate variability, and end organ damage in the TGR(mRen2)27 rat
    Megan S Johnson
    Department of Biological Sciences, University of Missouri, Columbia, Missouri, USA
    Am J Physiol Heart Circ Physiol 301:H1540-50. 2011
    The aim of this investigation was to evaluate sex differences in baroreflex and heart rate variability (HRV) dysfunction and indexes of end-organ damage in the TG(mRen2)27 (Ren2) rat, a model of renin overexpression and tissue renin-..
  92. ncbi Exercise training restores baroreflex sensitivity in never-treated hypertensive patients
    Mateus C Laterza
    Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Hypertension 49:1298-306. 2007
    The effects of exercise training on baroreflex control of sympathetic nerve activity in human hypertension are unknown...
  93. ncbi Central command: control of cardiac sympathetic and vagal efferent nerve activity and the arterial baroreflex during spontaneous motor behaviour in animals
    Kanji Matsukawa
    Department of Physiology, Graduate School of Health Sciences, Hiroshima University, Kasumi 1 2 3, Minami Ku, Hiroshima 734 8551, Japan
    Exp Physiol 97:20-8. 2012
    ..model to identify the neural circuitry involved in the CNS control of cardiac autonomic outflow and arterial baroreflex function...
  94. ncbi Effect of age on adrenergic and vagal baroreflex sensitivity in normal subjects
    Chih Cheng Huang
    Mayo Clinic, Department of Neurology, 200 First Street SW, Rochester, Minnesota 55905, USA
    Muscle Nerve 36:637-42. 2007
    The baroreflex maintains a stable blood pressure (BP) by dynamically adjusting heart rate (vagal component) and total peripheral resistance (adrenergic component)...
  95. ncbi Autonomic modulation of arterial pressure and heart rate variability in hypertensive diabetic rats
    Vera de Moura Azevedo Farah
    Hypertension Unit, Heart Institute, University of Sao Paulo, Medical School, Sao Paulo, Brazil
    Clinics (Sao Paulo) 62:477-82. 2007
    ..was to evaluate the autonomic modulation of the cardiovascular system in streptozotocin (STZ)-induced diabetic spontaneously hypertensive rats (SHR), evaluating baroreflex sensitivity and arterial pressure and heart rate variability.
  96. ncbi Chronic baroreflex activation: a potential therapeutic approach to heart failure with preserved ejection fraction
    Dimitrios Georgakopoulos
    CVRx Inc, 9201 West Broadway Avenue, Minneapolis, MN 55445, USA
    J Card Fail 17:167-78. 2011
    ..b>Baroreflex activation therapy (BAT) produced by stimulating the carotid sinuses using an implanted device (Rheos) is being ..
  97. pmc Circulating angiotensin II attenuates the sympathetic baroreflex by reducing the barosensitivity of medullary cardiovascular neurones in the rat
    Simon McMullan
    Hypertension and Stroke Research Laboratory, University of Sydney, NSW, Australia
    J Physiol 582:711-22. 2007
    ..We suggest that this results from activation by Ang II of a central pathway originating at the circumventricular organs...
  98. ncbi Baroreflex sensitivity and sympatho-vagal balance during intradialytic hypotensive episodes
    Dan Sapoznikov
    Nephrology and Hypertension Services, Hadassah University Medical Center, Jerusalem, Israel
    J Hypertens 28:314-24. 2010
    The role of the baroreflex function in the pathogenesis of hemodialysis-associated hypotension is controversial...
  99. ncbi Differential effect of head-up tilt on cardiovagal and sympathetic baroreflex sensitivity in humans
    D D O'Leary
    Neurovascular Research Laboratory, School of Kinesiology, The University of Western Ontario, London, Ontario, Canada N6A 3K7
    Exp Physiol 88:769-74. 2003
    ..determine the effect of baroreceptor unloading on the sensitivity of the cardiovagal and sympathetic arms of the baroreflex during upright posture...
  100. ncbi Aspirin restores normal baroreflex function in hypercholesterolemic rats by its antioxidative action
    Mohammad Tauseef
    Department of Physiology, Vallabhbhai Patel Chest Institute, University of Delhi, P O Box 2101, Delhi 110007, India
    Eur J Pharmacol 556:136-43. 2007
    ..present study we tested the hypothesis that aspirin by its antioxidant effect, improves haemodynamic profile and baroreflex sensitivity in rat model of hypercholesterolemia...
  101. ncbi Baroreflex sensitivity, heart rate, and blood pressure variability in normal pregnancy
    A Voss
    University of Applied Sciences, Jena, Germany
    Am J Hypertens 13:1218-25. 2000
    ..However, to use heart and blood pressure (BP) variability or baroreflex sensitivity as markers for hypertensive pregnancy disorders, it is first necessary to describe these parameters ..

Research Grants67

  1. Role of Chromogranin A in Metabolic Syndrome
    Sushil K Mahata; Fiscal Year: 2013
    ..2. Evaluate the potential therapeutic effects of CST and its variants on insulin sensitivity and baroreflex sensitivity and heart rate variability in high fat diet-induced insulin resistant and in db/db diabetic mice.
  2. Autonomic and Antihypertensive Actions of Neuronal CGRP/RAMP1 Receptors
    Mark W Chapleau; Fiscal Year: 2013
    ..he proposed studies will test the hypothesis that nervous system CGRP/RAMP1 receptors are powerful modulators of baroreflex sensitivity and autonomic activity capable of preventing or reversing hypertension...
  3. Glucocorticoids, Stress and Blood Pressure Regulation
    Deborah A Scheuer; Fiscal Year: 2013
    ..acts via both mineralocorticoid (MR) and glucocorticoid (GR) receptors to modulate stress responsiveness and baroreflex function by diminishing inhibitory and/or recruiting excitatory effects of catecholaminergic neurons in the ..
  4. Respiratory motor control and blood pressure regulation after spinal cord injury
    ALEXANDER VLADIMIROVICH OVECHKIN; Fiscal Year: 2013
    ..to the heart as a result of higher negative intrapleural pressure and/or higher sympathetic tone due to better baroreflex response in individuals with better inspiratory and expiratory motor control...
  5. VASODEPRESSOR MECHANISMS IN HYPERTENSION
    Carlos M Ferrario; Fiscal Year: 2013
    ..Understanding the regulation of this system is vital to the prevention of cardiovascular disease as well as in the design of effective therapies to reduce the consequences of the disease. ..
  6. Local Vasoconstriction in Postural Tachycardia Syndrome
    Julian M Stewart; Fiscal Year: 2013
    ..microneurography, popliteal artery ultrasound, and spontaneous BP oscillations will be used to assess MSNA, baroreflex activity, and the neurovascular transduction of MSNA to peripheral resistance...
  7. NEUROPHYSIOLOGY OF PARASYMPATHETIC CARDIAC NEURONS
    David Mendelowitz; Fiscal Year: 2013
    ..CIH impairs the baroreflex control of heart rate and diminishes cardioprotective parasympathetic activity to the heart and current research ..
  8. Omega-3 Fatty Acids, Neurohumoral Activation, and Human Heart Failure
    Kevin D Monahan; Fiscal Year: 2010
    ..As baroreflex dysfunction and neurohumoral activation contribute to the progression and poor prognosis associated with HF, ..
  9. Hostility, PTSD and Physical Health Risk Factors
    Jean C Beckham; Fiscal Year: 2013
    ..of cardiovascular risk measured from vascular endothelial function, 24-hour heart rate variability, and baroreflex sensitivity, and will determine whether the biomarkers of risk are highest among individuals with PTSD and high ..
  10. The baroreflex in pregnancy: effects of adrenal and placental steroids
    Maureen Keller-Wood; Fiscal Year: 2012
    ..In nonpregnant ewes cortisol increases blood pressure and heart rate, and decreases baroreflex sensitvity;adrenalectomy and total withdrawal from adrenal steroids causes decreased arterial pressure and ..
  11. Central TRPV1 in Cardiovascular Regulation
    MICHAEL CHRISTIAN ANDRESEN; Fiscal Year: 2013
    ....
  12. Beta2-Adrenergic Receptor Gene Variation and Cardiovascular Control in Humans
    John H Eisenach; Fiscal Year: 2012
    ..responses to systemic infusions of [unreadable]2-AR agonist, after temporary pharmacological ablation of baroreflex control of the circulation...
  13. Intervention for Menstrual Mood Disorders &Early Life Abuse: Biopsych Mechanisms
    Susan S Girdler; Fiscal Year: 2013
    ..Outcomes will be as for the intervention phase: daily symptom ratings, function and pain sensitivity (tested at months 3 and 6), as well as adherence. ..
  14. Central Endocannabinoid System Dysfunction and Hypertension
    Jeanne L Seagard; Fiscal Year: 2013
    ..The physiological importance of the baroreflex is underscored by the consequences of impaired baroreflex function - volatile BP, orthostatic hypotension, and ..
  15. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2010
    ..adjustment from seated or lying to standing posture involves the integration of central blood volume and the baroreflex response...
  16. Aging, Sex, and Neural Cardiovascular Control During Dynamic Exercise
    Paul J Fadel; Fiscal Year: 2012
    ..Given the importance of the arterial baroreflex (ABR) to neural cardiovascular control and responsiveness during exercise, a potential mechanism is impaired ABR ..
  17. Chemical Anatomy and Synaptology of Vestibulo-Sympathetic Pathways
    Gay R Holstein; Fiscal Year: 2013
    ..that arterial baroreceptors participate in a regulatory circuit that maintains sympathetic tone through the baroreflex while signals from the vestibular end organs drive a faster mechanism that counteracts the effects of a change ..
  18. Autonomic Rare Diseases Clinical Research Consortium
    DAVID HERLIE ROBERTSON; Fiscal Year: 2013
    ..include a norepinephrine transport blocker, a dopa decarboxylase antagonist, immunomodulatory therapy, a bionic baroreflex, and a potentially diseasearresting intervention in the uniformly fatal MSA...
  19. Mechanistic characterization of genes for hypertension and renal disease.
    Howard J Jacob; Fiscal Year: 2010
    ..This unique strategy will provide a mechanistic understanding of the pathophysiological role played by GWAS genes in hypertension and kidney disease. ..
  20. Neuromechanical basis of baroreceptor function
    John H Schild; Fiscal Year: 2010
    ..Experimental interpretations of baroreflex dysfunction and cardiovascular pathologies such as neurally mediated syncope, dysrhythmias and hypertension are ..
  21. Prenatal Events-Postnatal Consequences
    James C Rose; Fiscal Year: 2013
    ..in conjunction with the altered RAS, we find impairments in the ability to excrete a sodium load, decreases in baroreflex sensitivity (SRS) and heart rate variability (HRV) and increases in insulin resistance in the animal model...
  22. Stress Responses, Psychosocial Stress and Pain Perception in African Americans
    Susan S Girdler; Fiscal Year: 2010
    ..This proposal is intended to forge new territory in the development of a bio-behavioral model relating to the development of clinical pain in African Americans. Project Description ..
  23. Reactive Oxygen Species in Intermittent Hypoxia induced Sympathoexcitation
    PETER BERNARD RAVEN; Fiscal Year: 2012
    ..hypoxia (IH) causes a sustained increase in muscle sympathetic nerve activity (MSNA) and resets arterial baroreflex (ABR) function...
  24. Dysfunction of Baroreceptor Neurons in Heart Failure: Cellular and Molecular Mech
    Yu Long Li; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Clinical and animal studies have confirmed a contribution of arterial baroreflex impairment to the prognosis and mortality of chronic heart failure (CHF)...
  25. Psychosocial Factors and Aging: Resting/Reflexive Cardiovascular Control
    Richard P Sloan; Fiscal Year: 2013
    ..Measuring beat-to-beat BP along with RR intervals also allows for computation of baroreflex sensitivity (BRS), the relationship of reflexive changes in RR interval to changes in BP...
  26. Antihypertensive Effects of Tetanic Baraoreceptor Input Stimulation
    Xiaorui Tang; Fiscal Year: 2011
    ..We propose to test an alternative strategy: long-term potentiation of the endogenous baroreflex mechanisms by occasional, brief high frequency (tetanic) stimulation of the baroafferent pathway...
  27. Hypoglycemia, Cardiovascular Autonomic Function and Type 2 Diabetes Mellitus
    Roy Freeman; Fiscal Year: 2013
    ..studies, we showed that antecedent hypoglycemia resulted in significant decreases in: (i) cardiac vagal baroreflex sensitivity (ii) th sympathetic response to a transient pharmacologically induced hypotensive stress and (iii) ..
  28. CARDIOVASCULAR DYNAMICS AND THEIR CONTROL
    John E Hall; Fiscal Year: 2013
    ..chronically instrumented dogs to determine whether the CMS plays an important role in chronic resetting of the baroreflex and whether chronic activation of the baroreflex has sustained effects to inhibit renal sympathetic nerve ..
  29. THE BAROREFLEX MECHANISM: TRANSLATION TO AUD TREATMENT AND PROGNOSTIC MODELS
    Marsha E Bates; Fiscal Year: 2013
    ..clinical scientist addresses this gap by translating a new model of neurocardiac signaling (called the baroreflex [BAR] model) into behavioral interventions for AUDs...
  30. Dynamic blood pressure control and orthostatic tolerance in individuals with MS a
    Scott L Davis; Fiscal Year: 2013
    ..is markedly reduced during heat stress in otherwise healthy individuals, in part due to impairments in arterial baroreflex control, it is likely that heat stres in this patient population would further impair neural control of ..
  31. Mild Cognitive Impairment: Cerebrovascular Dysfunction and Exercise Training
    Rong Zhang; Fiscal Year: 2012
    ..Specific aim 1a: to determine whether baroreflex function is impaired, leading to enhanced blood pressure instability and thus hemodynamic challenges for brain ..
  32. PHYSIOLOGY OF THE PROLACTIN RELEASING PEPTIDES
    Willis K Samson; Fiscal Year: 2010
    ..e. baroreflex sensitivity)...
  33. Circulatory Dysfunction in Chronic Fatigue Syndrome
    Julian Stewart; Fiscal Year: 2004
    ..Cardiac autonomic status including baroreflex will be assessed by heart rate and blood pressure variability and transfer function...
  34. EXAMINING THE VASCULAR TONE BAROREFLEX AS A TARGET FOR ALCOHOL USE INTERVENTION
    Evgeny G Vaschillo; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This application seeks to examine the vascular tone baroreflex as a physiological mechanism that links the vascular actions of alcohol to adaptive behavior change...
  35. Blood pressure control by caudal ventrolateral medulla
    ANN SCHREIHOFER; Fiscal Year: 2009
    ..The role of GABAergic CVLM neurons in the baroreflex control of SNA is established, but baro-activated GABAergic CVLM neurons also tonically inhibit the RVLM ..
  36. Central GRK5 modulation of Angiotensin II receptor expression in heart failure
    KARLA HAACK; Fiscal Year: 2013
    ..be continuously recorded in order to derive additional indices of sympatho-excitation and to determine arterial baroreflex function. Sympathetic nerve activity will be directly recorded under anesthesia in terminal experiments...
  37. Hypoglycemia, mineralocorticoid receptor and autonomic control
    Roy Freeman; Fiscal Year: 2013
    ..studies, we showed that antecedent hypoglycemia resulted in significant decreases in: (i) cardiac vagal baroreflex sensitivity (ii) the sympathetic response to a transient pharmacologically induced hypotensive stress and (iii) ..
  38. Central nervous system plasticity in sympathoinhibition in pregnancy
    Cheryl M Heesch; Fiscal Year: 2012
    ..Summary: In normal pregnancy resetting of volume control systems maintains elevated blood volume, and arterial baroreflex control of sympathetic outflow is adapted to protect against hypertension, at the expense of compensatory ..
  39. BLOOD PRESSURE CONTROL DURING EXERCISE IN HEART FAILURE
    DONAL S O'LEARY; Fiscal Year: 2013
    ..Previous studies have implicated abnormal activation of the muscle metaboreflex and arterial baroreflex in mediating these responses...
  40. Mechanisms underlying altered automic regulation of blood pressure in obesity
    Ann M Schreihofer; Fiscal Year: 2010
    ..Obese people display hypertension, impaired baroreflex control of arterial pressure (AP), and exaggerated pressor responses to stress, which contribute to end-organ ..
  41. Blood pressure control by caudal ventrolateral medulla
    Ann M Schreihofer; Fiscal Year: 2013
    ..The role of GABAergic CVLM neurons in the baroreflex control of SNA is well established, but baro-activated GABAergic CVLM neurons also tonically inhibit the RVLM ..
  42. HYBRID-FES EXERCISE TO PREVENT CARDIOVASCULAR DECLINES IN ACUTE SPINAL CORD INJUR
    J Andrew Taylor; Fiscal Year: 2013
    ..increased visceral adiposity and reduced insulin sensitivity, 2) prevent worsening lipid profile and compromised baroreflex function, and 3) counter ventricular wall thickening and declining ventricular function occurring with acute SCI,..
  43. TRPV1 mediation of local vasoconstrictor reflexes in spinal cord injured humans
    Dean L Kellogg; Fiscal Year: 2013
    ..of special importance in maintaining hemodynamic stability after spinal cord injury (SCI) where there is loss of baroreflex mediated sympathetic vasoconstriction;indeed, these vasoconstrictor responses may even be enhanced in SCI...
  44. Data Coordinating Center for VEST and PREDICTS
    Stephen B Hulley; Fiscal Year: 2010
    ..in which participants in VEST will undergo a battery of risk stratification tests including T wave alternans, baroreflex sensitivity, Holter monitoring and 7 other likely predictors before placement of an ICD...
  45. STRESS, BLOOD PRESSURE AND ETHNICITY
    Joel E Dimsdale; Fiscal Year: 2010
    ..Vasoactive agonists will be infused and/or inhaled to assess baroreflex functioning, beta-adrenergic sensitivity, and vasodilatory response...
  46. BAROREFLEX AND POSTERIOR HYPOTHALAMIC NEUROPEPTIDE-Y
    John Martin; Fiscal Year: 1991
    ..of the baroreceptor reflex, and to determine the role of plasma vasopressin (AVP) in the observed changes in baroreflex sensitivity...
  47. Integrative Cardiovascular Control During Exercise in Hypertension
    DONAL S O apos LEARY; Fiscal Year: 2010
    ..Furthermore, the mechanisms of the muscle metaboreflex are intimately dependent on the arterial baroreflex. Although, it is known that hypertension impairs baroreflex function at rest, whether exercise further alters ..
  48. RCT of Controlled Breathing Effects on Ambulatory BP
    Lynn Clemow; Fiscal Year: 2011
    ..We also propose to study a physiological mechanism, baroreflex sensitivity, that may mediate the effect of the intervention on BP...
  49. Arterial Baroreflex Function in African Americans at Rest and During Exercise
    David Keller; Fiscal Year: 2009
    ..e., arterial baroreflex function) in African Americans...
  50. CONTROL OF VASCULAR TONE BY CONTINGENT CNS STIMULATION
    Barry Dworkin; Fiscal Year: 2006
    ..The applicants have shown (1) that the depressor effects of the aortic baroreflex can be classically conditioned, and (2) formulated mathematical models that predict that the conditioning can ..
  51. ABDOMINAL FAT AND AUTONOMIC CIRCULATORY CONTROL IN HUMAN
    Kevin Davy; Fiscal Year: 2003
    ..of elevated abdominal visceral fat on: 1) basal cardiac vagal modulation of heart rate and MSNA and 2) arterial baroreflex stimulation of cardiac vagal outflow and arterial baroreflex inhibition of MSNA...
  52. Modeling Central Autonomic Regulatory Network Adaptation to Hypertension
    Rajanikanth Vadigepalli; Fiscal Year: 2013
    ..The predictions will be tested by in vivo genetic manipulation and molecular and physiological assays to reveal molecular interactions critical to maintaining normal blood pressure. ..
  53. INTERACTION OF CARDIOVASCULAR REFLEXES IN EXERCISE
    Gary Mack; Fiscal Year: 1992
    ..We will examine the stimulus-response characteristics of each baroreflex by selectively manipulating either carotid sinus transmural or central venous pressure...
  54. Oxytocin enhances afferent synaptic transmission within the NTS.
    JAMES PETERS; Fiscal Year: 2009
    ..acting in NTS slows the heart and decreases arterial pressure, an action consistent with an enhancement of the baroreflex;the mechanisms of these effects, however, remain unknown...
  55. Trigeminal Autonomic Interactions
    Paul McCulloch; Fiscal Year: 2002
    ..It is hypothesized that stimulation of the trigeminal inhibits the baroreflex at the level of the nucleus tractus solitarius (NTS)...
  56. EFFECT OF SODIUM ON BAROREFLEX FUNCTION IN MAN
    Mark Creager; Fiscal Year: 1991
    Abnormalities in baroreflex function and vascular responsiveness may be intrinsic to the pathophysiology of hypertension...
  57. AUTONOMIC MECHANISMS IN NEURALLY MEDIATED SYNCOPE
    Daniel Bloomfield; Fiscal Year: 2000
    ..function and the reflex response of the autonomic nervous system to head-up tilt using RR variability and baroreflex sensitivity...
  58. CAROTID BAROREFLEX CONTROL IN NORMO- AND HYPERTENSION
    MARTHA BRUNNER; Fiscal Year: 1992
    ..The proposed research will focus on three aspects of baroreflex function in hypertension: changes in receptor function in hypertension, baroreflex control in vasoactive hormone ..
  59. EXERCISE TRAINING AND BARORECEPTOR FUNCTION
    Peter Raven; Fiscal Year: 1990
    ..pressure during an orthostatic challenge suggests that orthostatic tolerance is reduced because of an attenuated baroreflex. Endurance exercise training is known to produce an increase in total blood volume, primarily plasma volume and ..
  60. SODIUM CHLORIDE AND HYPERTENSION
    Theodore Kotchen; Fiscal Year: 1990
    ..that salt sensitivity is related to an expanded ECF volume, increased sympathetic tone, and/or decreased baroreflex sensitivity...
  61. AUTONOMIC NEURAL EFFECTS OF DIETARY CALCIUM
    JACOB PEULER; Fiscal Year: 1992
    ..2) Baroreflex control was significantly augmented by high Ca diet...
  62. Hyperpnea in Orthostatic Intolerance
    Julian Stewart; Fiscal Year: 2009
    ..We hypothesize that excessive baroreflex unloading during orthostatic stress is the initiating event in POTS resulting in 1) reduced inhibition of ..
  63. BLOOD PRESSURE CONTROL IN EXPERIMENTAL HEART DISEASE
    NICHOLAS OLIVIER; Fiscal Year: 1991
    ..Complete stimulus-response relations for the carotid baroreflex will be determined for the first time in conscious dogs before, during, and following the reversal of pacing-..
  64. Time Domains of Sympathetic Activity following Hypoxia
    James Weiss; Fiscal Year: 2006
    ..that brief exposures to hypoxia produce sustained sympathoexcitation primarily through engagement of arterial baroreflex mechanisms...
  65. BAROREFLEXES AND ORTHOSTATISM--FITNESS EFFECT
    Peter Raven; Fiscal Year: 1993
    ..atropine sulphate and metoprolol tartrate, we will isolate the cardias and vascular components of the carotid baroreflex. these procedures will be carried out using a cross-sectional design on two groups of subject designated as ..
  66. CEREBROVASCULAR HEMODYNAMICS IN PRETERM BRAIN INJURY
    TIMOTHY WATKINS; Fiscal Year: 2001
    ..rate, oscillations of blood pressure, and oscillations of cerebral blood flow will be quantified: the arterial baroreflex, cerebral autoregulation, and the relation of the arterial baroreflex to cerebral autoregulation...