psychological stress

Summary

Summary: Stress wherein emotional factors predominate.

Top Publications

  1. ncbi Association of psychosocial risk factors with risk of acute myocardial infarction in 11119 cases and 13648 controls from 52 countries (the INTERHEART study): case-control study
    Annika Rosengren
    Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    Lancet 364:953-62. 2004
  2. ncbi A neurotrophic model for stress-related mood disorders
    Ronald S Duman
    Division of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 59:1116-27. 2006
  3. ncbi Adverse health effects of high-effort/low-reward conditions
    J Siegrist
    Institute of Medical Sociology, University of Dusseldorf, Germany
    J Occup Health Psychol 1:27-41. 1996
  4. ncbi Short screening scales to monitor population prevalences and trends in non-specific psychological distress
    R C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    Psychol Med 32:959-76. 2002
  5. ncbi Systematic review of depression, anxiety, and other indicators of psychological distress among U.S. and Canadian medical students
    Liselotte N Dyrbye
    Mayo Clinic, 200 First Street SW, Rochester, MN 55906, USA
    Acad Med 81:354-73. 2006
  6. ncbi Psychological stress and disease
    Sheldon Cohen
    Department of Psychology, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    JAMA 298:1685-7. 2007
  7. ncbi A review of empirical studies on the model of effort-reward imbalance at work: reducing occupational stress by implementing a new theory
    Akizumi Tsutsumi
    Okayama University Graduate School of Medicine and Dentistry, Hygiene and Preventive Medicine, 2 5 1 Shikata cho, Okayama, 700 8558, Japan
    Soc Sci Med 59:2335-59. 2004
  8. ncbi Biobehavioral responses to stress in females: tend-and-befriend, not fight-or-flight
    S E Taylor
    Department of Psychology, University of California, Los Angeles 90095 1563, USA
    Psychol Rev 107:411-29. 2000
  9. pmc Environmental health disparities: a framework integrating psychosocial and environmental concepts
    Gilbert C Gee
    University of Michigan School of Public Health, Department of Health Behavior and Health Education, Ann Arbor, Michigan, USA
    Environ Health Perspect 112:1645-53. 2004
  10. ncbi The measurement of effort-reward imbalance at work: European comparisons
    Johannes Siegrist
    Department of Medical Sociology, University of Duesseldorf, PO Box 10 10 07, D 40001 Duesseldorf, Germany
    Soc Sci Med 58:1483-99. 2004

Detail Information

Publications362 found, 100 shown here

  1. ncbi Association of psychosocial risk factors with risk of acute myocardial infarction in 11119 cases and 13648 controls from 52 countries (the INTERHEART study): case-control study
    Annika Rosengren
    Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    Lancet 364:953-62. 2004
    ..The aim of the present analysis was to investigate the relation of psychosocial factors to risk of myocardial infarction in 24767 people from 52 countries...
  2. ncbi A neurotrophic model for stress-related mood disorders
    Ronald S Duman
    Division of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 59:1116-27. 2006
    ....
  3. ncbi Adverse health effects of high-effort/low-reward conditions
    J Siegrist
    Institute of Medical Sociology, University of Dusseldorf, Germany
    J Occup Health Psychol 1:27-41. 1996
    ..Studying adverse health effects of high-effort/low-reward conditions seems well justified, especially in view of recent developments of the labor market...
  4. ncbi Short screening scales to monitor population prevalences and trends in non-specific psychological distress
    R C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    Psychol Med 32:959-76. 2002
    ..A 10-question screening scale of psychological distress and a six-question short-form scale embedded within the 10-question scale were developed for the redesigned US National Health Interview Survey (NHIS)...
  5. ncbi Systematic review of depression, anxiety, and other indicators of psychological distress among U.S. and Canadian medical students
    Liselotte N Dyrbye
    Mayo Clinic, 200 First Street SW, Rochester, MN 55906, USA
    Acad Med 81:354-73. 2006
    ..To systematically review articles reporting on depression, anxiety, and burnout among U.S. and Canadian medical students...
  6. ncbi Psychological stress and disease
    Sheldon Cohen
    Department of Psychology, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    JAMA 298:1685-7. 2007
  7. ncbi A review of empirical studies on the model of effort-reward imbalance at work: reducing occupational stress by implementing a new theory
    Akizumi Tsutsumi
    Okayama University Graduate School of Medicine and Dentistry, Hygiene and Preventive Medicine, 2 5 1 Shikata cho, Okayama, 700 8558, Japan
    Soc Sci Med 59:2335-59. 2004
    ..Since the theory-based intervention depends largely on organizational changes that are beyond the individual employees' ability, the cooperation of employers is necessary...
  8. ncbi Biobehavioral responses to stress in females: tend-and-befriend, not fight-or-flight
    S E Taylor
    Department of Psychology, University of California, Los Angeles 90095 1563, USA
    Psychol Rev 107:411-29. 2000
    ..This previously unexplored stress regulatory system has manifold implications for the study of stress...
  9. pmc Environmental health disparities: a framework integrating psychosocial and environmental concepts
    Gilbert C Gee
    University of Michigan School of Public Health, Department of Health Behavior and Health Education, Ann Arbor, Michigan, USA
    Environ Health Perspect 112:1645-53. 2004
    ..When not counterbalanced by resources, stressors may lead to heightened vulnerability to environmental hazards...
  10. ncbi The measurement of effort-reward imbalance at work: European comparisons
    Johannes Siegrist
    Department of Medical Sociology, University of Duesseldorf, PO Box 10 10 07, D 40001 Duesseldorf, Germany
    Soc Sci Med 58:1483-99. 2004
    ..In the light of the importance of work for adult health such investigations are crucial in advanced societies within and beyond Europe...
  11. ncbi Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change
    Jens C Pruessner
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada
    Psychoneuroendocrinology 28:916-31. 2003
    ..It is shown that depending on which formula is used, different associations with other variables may emerge. Consequently, it is recommended to employ both formulas when analyzing data sets with repeated measures...
  12. ncbi The prevalence of psychological distress by cancer site
    J Zabora
    The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Psychooncology 10:19-28. 2001
    ..Failure to detect and treat elevated levels of distress jeopardizes the outcomes of cancer therapies, decreases patients' quality of life, and increases health care costs...
  13. pmc High levels of untreated distress and fatigue in cancer patients
    L E Carlson
    Department of Psychosocial Resources, Tom Baker Cancer Centre, Alberta Cancer Board, Calgary, Alberta, Canada
    Br J Cancer 90:2297-304. 2004
    ..Many patients who report high levels of distress are not taking advantage of available supportive resources. Barriers to such use, and factors predicting distress and use of psychosocial care, require further exploration...
  14. ncbi Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
    Olivier Berton
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Science 311:864-8. 2006
    ..These results establish an essential role for BDNF in mediating long-term neural and behavioral plasticity in response to aversive social experiences...
  15. ncbi Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states
    P W Gold
    Clinical Neuroendocrinology Branch, Intramural Research Program, NIMH NIH, NIH Clinical Center, Room 2D 46 1284, Bethesda, MD 20892 1284, USA
    Mol Psychiatry 7:254-75. 2002
    ....
  16. pmc Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry
    Suzanne C Segerstrom
    Department of Psychology, University of Kentucky, Lexington, KY 40506, USA
    Psychol Bull 130:601-30. 2004
    The present report meta-analyzes more than 300 empirical articles describing a relationship between psychological stress and parameters of the immune system in human participants...
  17. ncbi Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
    Avshalom Caspi
    Medical Research Council Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, PO80 De Crespigny Park, London, SE5 8AF, UK
    Science 301:386-9. 2003
    ..This epidemiological study thus provides evidence of a gene-by-environment interaction, in which an individual's response to environmental insults is moderated by his or her genetic makeup...
  18. ncbi Stress and depression among medical students: a cross-sectional study
    Marie Dahlin
    Department of Clinical Neuroscience, Section Psychiatry, St Göran, Stockholm, Sweden
    Med Educ 39:594-604. 2005
    ..To assess the exposure to different stressors and the prevalence of depression among medical students at different levels of education, taking gender differences into account...
  19. ncbi Interpreting scores on the Kessler Psychological Distress Scale (K10)
    G Andrews
    World Health Organization Collaborating Centre in Evidence for Mental Health Policy and School of Psychiatry, University of New South Wales at St Vincent s Hospital, Darlinghurst
    Aust N Z J Public Health 25:494-7. 2001
    ..To provide normative data on the Kessler Psychological Distress Scale (K10), a scale that is being increasingly used for clinical and epidemiological purposes...
  20. pmc Accelerated telomere shortening in response to life stress
    Elissa S Epel
    Department of Psychiatry, University of California, 3333 California Street, Suite 465, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 101:17312-5. 2004
    ..Here we provide evidence that psychological stress--both perceived stress and chronicity of stress--is significantly associated with higher oxidative stress, ..
  21. pmc Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine
    B Czeh
    Division of Neurobiology, German Primate Center, 37077 Gottingen, Germany
    Proc Natl Acad Sci U S A 98:12796-801. 2001
    ..These findings provide a cellular and neurochemical basis for evaluating antidepressant treatments with regard to possible reversal of structural changes in brain that have been reported in depressive disorders...
  22. ncbi The short-form version of the Depression Anxiety Stress Scales (DASS-21): construct validity and normative data in a large non-clinical sample
    Julie D Henry
    School of Psychology, University of New South Wales, Australia
    Br J Clin Psychol 44:227-39. 2005
    ..To provide normative data for the general adult population...
  23. ncbi Impact of gender, menstrual cycle phase, and oral contraceptives on the activity of the hypothalamus-pituitary-adrenal axis
    C Kirschbaum
    Center for Psychobiological and Psychosomatic Research, University of Trier, Germany
    Psychosom Med 61:154-62. 1999
    ..The aim of the present study was to investigate sex-specific HPA response patterns with a focus on the contribution of gonadal steroids as possible mediators...
  24. doi Acute psychological stress reduces working memory-related activity in the dorsolateral prefrontal cortex
    Shaozheng Qin
    Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands
    Biol Psychiatry 66:25-32. 2009
    Acute psychological stress impairs higher-order cognitive function such as working memory (WM)...
  25. pmc Perfusion functional MRI reveals cerebral blood flow pattern under psychological stress
    Jiongjiong Wang
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 102:17804-9. 2005
    ..Our results provide neuroimaging evidence that psychological stress induces negative emotion and vigilance and that the ventral RPFC plays a key role in the central stress ..
  26. pmc A functional genomic fingerprint of chronic stress in humans: blunted glucocorticoid and increased NF-kappaB signaling
    Gregory E Miller
    Department of Psychology, University of British Columbia, Vancouver, Canada
    Biol Psychiatry 64:266-72. 2008
    ..Chronic stressors are known to increase vulnerability to medical illness, but the mechanisms underlying this phenomenon are poorly understood...
  27. ncbi Chronic psychological stress and the regulation of pro-inflammatory cytokines: a glucocorticoid-resistance model
    Gregory E Miller
    Department of Psychology, Washington University, St Louis, Missouri 63130, USA
    Health Psychol 21:531-41. 2002
    ..Findings suggest a novel pathway by which chronic stress might alter the course of inflammatory disease...
  28. ncbi Effects of an integrated yoga program in modulating psychological stress and radiation-induced genotoxic stress in breast cancer patients undergoing radiotherapy
    Birendranath Banerjee
    Genome Stability Laboratory, Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Integr Cancer Ther 6:242-50. 2007
    ..An integrated approach of yoga intervention modulates the stress and DNA damage levels in breast cancer patients during radiotherapy...
  29. ncbi Work stress in the etiology of coronary heart disease--a meta-analysis
    Mika Kivimaki
    Finnish Insitute of Occupational Health, Topeliuksenkatu 41 a A, FI 00250 Helsinki, Finland
    Scand J Work Environ Health 32:431-42. 2006
    ..This study focused on estimating the relative risk of coronary heart disease (CHD) in association with work stress, as indicated by the job-strain model, the effort-reward imbalance model, and the organizational injustice model...
  30. ncbi Reviewing the effort-reward imbalance model: drawing up the balance of 45 empirical studies
    Natasja van Vegchel
    Department of Social and Organizational Psychology, Utrecht University, P O Box 80 140, 3508 TC Utrecht, The Netherlands
    Soc Sci Med 60:1117-31. 2005
    ..Based on these review results suggestions for future research are proposed...
  31. ncbi Sex differences in HPA axis responses to stress: a review
    Brigitte M Kudielka
    Department of Clinical and Theoretical Psychobiology, University of Trier, Johanniterufer 15, D 54290 Trier, Germany
    Biol Psychol 69:113-32. 2005
  32. ncbi Psychological stress and the risk of breast cancer: a case-control study
    Joanna Kruk
    Institute of Physical Education, Faculty of Natural Sciences, University of Szczecin, Al Piastów 40b 6, 71 065 Szczecin, Poland
    Cancer Detect Prev 28:399-408. 2004
    To determine whether psychological stress, in the form of past life events and stress at work, was associated with the development of breast cancer.
  33. ncbi Marriage and health: his and hers
    J K Kiecolt-Glaser
    Department of Psychiatry, Ohio State University College of Medicine, 1670 Upham Drive, Columbus, Ohio 43210, USA
    Psychol Bull 127:472-503. 2001
    ..Contemporary models of gender that emphasize self-processes, traits, and roles furnish alternative perspectives on the differential costs and benefits of marriage for men's and women's health...
  34. ncbi Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research
    Sally S Dickerson
    Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA
    Psychol Bull 130:355-91. 2004
    ..These findings are consistent with the animal literature on the physiological effects of uncontrollable social threat and contradict the belief that cortisol is responsive to all types of stressors...
  35. pmc Chronic stress and age-related increases in the proinflammatory cytokine IL-6
    Janice K Kiecolt-Glaser
    Department of Psychiatry, Ohio State University College of Medicine, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 100:9090-5. 2003
    ..These data provide evidence of a key mechanism through which chronic stressors may accelerate risk of a host of age-related diseases by prematurely aging the immune response...
  36. ncbi The effects of acute psychological stress on circulating inflammatory factors in humans: a review and meta-analysis
    Andrew Steptoe
    Psychobiology Group, Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1 6BT, UK
    Brain Behav Immun 21:901-12. 2007
    ..humans, and evidence is beginning to emerge showing that circulating inflammatory factors respond to acute psychological stress under laboratory conditions...
  37. ncbi A randomized, wait-list controlled clinical trial: the effect of a mindfulness meditation-based stress reduction program on mood and symptoms of stress in cancer outpatients
    M Speca
    Department of Psychosocial Resources, Tom Baker Cancer Centre, Alberta Cancer Board, Canada
    Psychosom Med 62:613-22. 2000
    ..The objective of this study was to assess the effects of participation in a mindfulness meditation-based stress reduction program on mood disturbance and symptoms of stress in cancer outpatients...
  38. ncbi Role of adrenal stress hormones in forming lasting memories in the brain
    James L McGaugh
    Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, California 92697 3800, USA
    Curr Opin Neurobiol 12:205-10. 2002
    ..Release of norepinephrine and activation of beta-adrenoceptors within the basolateral amygdala is critical in mediating adrenal stress hormone regulation of memory consolidation...
  39. ncbi The benefits of being present: mindfulness and its role in psychological well-being
    Kirk Warren Brown
    Department of Clinical and Social Sciences in Psychology, University of Rochester, New York 14627 0266, USA
    J Pers Soc Psychol 84:822-48. 2003
    ..Finally, a clinical intervention study with cancer patients demonstrates that increases in mindfulness over time relate to declines in mood disturbance and stress...
  40. ncbi Are psychosocial factors, risk factors for symptoms and signs of the shoulder, elbow, or hand/wrist?: A review of the epidemiological literature
    Paulien M Bongers
    TNO Work and Employment, AS Hoofddorp, The Netherlands
    Am J Ind Med 41:315-42. 2002
    ..Since then, additional reviews on this topic have been published; however, none of these focussed on upper limb problems...
  41. pmc Work stress and risk of cardiovascular mortality: prospective cohort study of industrial employees
    Mika Kivimaki
    Department of Psychology, University of Helsinki, PO Box 13, FIN 00014, Finland
    BMJ 325:857. 2002
    ..To examine the association between work stress, according to the job strain model and the effort-reward imbalance model, and the risk of death from cardiovascular disease...
  42. ncbi Noise stress impairs prefrontal cortical cognitive function in monkeys: evidence for a hyperdopaminergic mechanism
    A F Arnsten
    Section of Neurobiology, Yale Medical School, New Haven, Conn 06520 8001, USA
    Arch Gen Psychiatry 55:362-8. 1998
    ..Our study examined the effects of acute, mild stress exposure on higher cognitive function in monkeys and the role of dopaminergic mechanisms in the stress response...
  43. doi Effects of psychological stress on serum iron and erythropoiesis
    Chunlan Wei
    Department of Naval Medicine, Second Military Medical University, Shanghai 200433, China
    Int J Hematol 88:52-6. 2008
    ..However, so far whether pure psychological stress can cause decrease of serum iron and consequently affect erythropoiesis has not been reported...
  44. ncbi The prevalence, distribution, and mental health correlates of perceived discrimination in the United States
    R C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    J Health Soc Behav 40:208-30. 1999
    ....
  45. pmc Chronic stress and obesity: a new view of "comfort food"
    Mary F Dallman
    Department of Physiology and Neuroscience Program, University of California, San Francisco, CA 94143 0444, USA
    Proc Natl Acad Sci U S A 100:11696-701. 2003
    ..These mechanisms, determined in rats, may explain some of the epidemic of obesity occurring in our society...
  46. ncbi Medical student distress: causes, consequences, and proposed solutions
    Liselotte N Dyrbye
    Department of Internal Medicine and Division of Primary Care Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 80:1613-22. 2005
    ..In this article, we review the manifestations and causes of student distress, its potential adverse personal and professional consequences, and proposed institutional approaches to decrease student distress...
  47. doi Stress, sensitive periods and maturational events in adolescent depression
    Susan L Andersen
    Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Trends Neurosci 31:183-91. 2008
    ..Adolescent depression is a serious recurrent brain-based disorder. Understanding the genesis and neurobiological basis is important in the development of more effective intervention strategies to treat or prevent the disorder...
  48. pmc Gender difference in neural response to psychological stress
    Jiongjiong Wang
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Soc Cogn Affect Neurosci 2:227-39. 2007
    ..b>Psychological stress was elicited using mental arithmetic tasks under varying pressure...
  49. ncbi Patients' recollections of stressful experiences while receiving prolonged mechanical ventilation in an intensive care unit
    Armando J Rotondi
    University of Pittsburgh, Pittsburgh, PA
    Crit Care Med 30:746-52. 2002
    ..To describe stressful experiences of adult patients who received mechanical ventilation for > or =48 hrs in an intensive care unit...
  50. ncbi Physical activity dose-response effects on outcomes of depression and anxiety
    A L Dunn
    The Cooper Institute, Dallas, TX 75230, USA
    Med Sci Sports Exerc 33:S587-97; discussion 609-10. 2001
    ..The purpose of this study was to examine the scientific evidence for a dose-response relation of physical activity with depressive and anxiety disorders...
  51. ncbi Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors
    Lisa M Monteggia
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Biol Psychiatry 61:187-97. 2007
    ....
  52. ncbi Blood pressure reactivity to psychological stress predicts hypertension in the CARDIA study
    Karen A Matthews
    University of Pittsburgh, 3811 O Hara St, Pittsburgh, PA, USA
    Circulation 110:74-8. 2004
    ..hypothesis is that individuals who exhibit frequent, large increases in blood pressure (BP) during psychological stress are at risk for developing essential hypertension...
  53. ncbi HPA axis responses to laboratory psychosocial stress in healthy elderly adults, younger adults, and children: impact of age and gender
    B M Kudielka
    Department of Behavioural Sciences, Swiss Federal Institute of Technology ETH, Turnerstr 1, CH 8092, Zurich, Switzerland
    Psychoneuroendocrinology 29:83-98. 2004
    ..It can be speculated if corticosteroid binding globulin (CBG) and/or sex steroids are important modulators of these effects...
  54. ncbi Acute stress rapidly and persistently enhances memory formation in the male rat
    T J Shors
    Department of Psychology and Center for Neuroscience, Rutgers University, Piscataway, New Jersey 08854 8020, USA
    Neurobiol Learn Mem 75:10-29. 2001
    ..These studies extend the circumstances under which stress is known to enhance associative learning and implicate neural mechanisms of memory enhancement that are rapidly induced and persistently expressed...
  55. ncbi Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations
    M J Meaney
    Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, Department of Psychiatry and McGill Centre for the Study of Behavior, Genes and Environment, McGill University, Montreal, Canada
    Annu Rev Neurosci 24:1161-92. 2001
    ..These findings provide evidence for the importance of parental care as a mediator of the effects of environmental adversity on neural development...
  56. ncbi The well-being of physicians
    Tait D Shanafelt
    Mayo Clinic, Rochester, Minnesota, USA
    Am J Med 114:513-9. 2003
  57. pmc Accelerated telomere erosion is associated with a declining immune function of caregivers of Alzheimer's disease patients
    Amanda K Damjanovic
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Immunol 179:4249-54. 2007
    ..These findings demonstrate that chronic stress is associated with altered T cell function and accelerated immune cell aging as suggested by excessive telomere loss...
  58. ncbi Risky families: family social environments and the mental and physical health of offspring
    Rena L Repetti
    Department of Psychology, University of California, Los Angeles, 90095 1563, USA
    Psychol Bull 128:330-66. 2002
    ..We conclude that childhood family environments represent vital links for understanding mental and physical health across the life span...
  59. ncbi Depression and cortisol responses to psychological stress: a meta-analysis
    Heather M Burke
    Department of Psychiatry, University of California, San Francisco, USA
    Psychoneuroendocrinology 30:846-56. 2005
    ..This blunted reactivity-impaired recovery pattern observed among the afternoon studies was most pronounced in studies with older and more severely depressed patients...
  60. ncbi Psychosocial work environment and mental health--a meta-analytic review
    Stephen Stansfeld
    Centre for Psychiatry, Wolfson Institute of Preventive Medicine, Joseph Rotblat Building, Barts and London, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1 6BQ, United Kindom
    Scand J Work Environ Health 32:443-62. 2006
    ....
  61. ncbi Stress-induced alterations in prefrontal cortical dendritic morphology predict selective impairments in perceptual attentional set-shifting
    Conor Liston
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 26:7870-4. 2006
    ..This study provides the first direct evidence that dendritic remodeling in the prefrontal cortex may underlie the functional deficits in attentional control that are symptomatic of stress-related mental illnesses...
  62. pmc Psychological stress and cardiovascular disease
    Joel E Dimsdale
    University of California, San Diego, La Jolla, California 92093, USA
    J Am Coll Cardiol 51:1237-46. 2008
    There is an enormous amount of literature on psychological stress and cardiovascular disease...
  63. ncbi Post-traumatic stress disorder
    Rachel Yehuda
    Division of Traumatic Stress Studies and Department of Psychiatry, Mount Sinai School of Medicine and Bronx Veterans Affairs Medical Center, New York 10468, USA
    N Engl J Med 346:108-14. 2002
  64. doi Psychological stress and wound healing in humans: a systematic review and meta-analysis
    Jessica Walburn
    Institute of Psychiatry, Department of Psychology, King s College London, SE1 9RT London, UK
    J Psychosom Res 67:253-71. 2009
    The current review aims to synthesize existing knowledge about the relationship between psychological stress and wound healing.
  65. pmc Stress, burnout and doctors' attitudes to work are determined by personality and learning style: a twelve year longitudinal study of UK medical graduates
    I C McManus
    Department of Psychology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    BMC Med 2:29. 2004
    ....
  66. ncbi Effects of physical exercise on anxiety, depression, and sensitivity to stress: a unifying theory
    P Salmon
    Department of Clinical Psychology, University of Liverpool, Whelan Building, Liverpool L69 3GB, United Kingdom
    Clin Psychol Rev 21:33-61. 2001
    ..It also offers a specific psychological treatment that may be particularly effective for patients for whom more conventional psychological interventions are less acceptable...
  67. pmc Probiotics prevent bacterial translocation and improve intestinal barrier function in rats following chronic psychological stress
    M Zareie
    Division of Gastroenterology and Nutrition, Room 8409, Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada
    Gut 55:1553-60. 2006
    Chronic psychological stress, including water avoidance stress (WAS), induces intestinal mucosal barrier dysfunction and impairs mucosal defences against luminal bacteria...
  68. ncbi Genetic factors, perceived chronic stress, and the free cortisol response to awakening
    S Wust
    Center for Psychobiological and Psychosomatic Research, University of Trier, Dietrichstrasse 10 11, 54290, Trier, Germany
    Psychoneuroendocrinology 25:707-20. 2000
    ..In line with several recent studies, the present findings further support the view that the cortisol awakening responses is consistently enhanced under chronic stress conditions...
  69. pmc A mechanism converting psychosocial stress into mononuclear cell activation
    Angelika Bierhaus
    Department of Medicine I, University of Heidelberg, Otto Meyerhof Zentrum, Im Neuenheimer Feld 350, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 100:1920-5. 2003
    ..Activation of NF-kappaB represents a downstream effector for the neuroendocrine response to stressful psychosocial events and links changes in the activity of the neuroendocrine axis to the cellular response...
  70. ncbi A cognitive model of posttraumatic stress disorder
    A Ehlers
    Department of Psychiatry, University of Oxford, Warneford Hospital, UK
    Behav Res Ther 38:319-45. 2000
    ..Recent studies have provided preliminary support for several aspects of the model...
  71. ncbi Effect of psychological stress on the salivary cortisol and amylase levels in healthy young adults
    Noriyasu Takai
    Department of Physiology, Osaka Dental University, 8 1, Kuzuha hanazono cho, Hirakata, Osaka 573 1121, Japan
    Arch Oral Biol 49:963-8. 2004
    ..We examined the effects of psychological stressor and soother on the salivary cortisol and amylase levels in young adults, and compared the characteristics of these parameters...
  72. pmc Chronic stress at work and the metabolic syndrome: prospective study
    Tarani Chandola
    Department of Epidemiology and Public Health, University College London, London WC1E 6BT
    BMJ 332:521-5. 2006
    ..To investigate the association between stress at work and the metabolic syndrome. [table: see text]...
  73. ncbi Stress, inflammation and cardiovascular disease
    Paul H Black
    epartment of Microbiology, Boston University School of Medicine, Room L 504, 715 Albany Street, Boston, MA 02118, USA
    J Psychosom Res 52:1-23. 2002
    ..In this article, we review the evidence that repeated episodes of acute psychological stress, or chronic psychologic stress, may induce a chronic inflammatory process culminating in atherosclerosis...
  74. ncbi Differences between caregivers and noncaregivers in psychological health and physical health: a meta-analysis
    Martin Pinquart
    Department of Developmental Psychology, Friedrich Schiller University, Jena, Germany
    Psychol Aging 18:250-67. 2003
    ..Differences were also influenced by the quality of the study, relationship of caregiver to the care recipient, gender, and mean age of caregivers...
  75. pmc How do distress and well-being relate to medical student empathy? A multicenter study
    Matthew R Thomas
    Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Gen Intern Med 22:177-83. 2007
    ....
  76. ncbi Psychological stress in undergraduate dental students: baseline results from seven European dental schools
    Gerry Humphris
    Department of Clinical Psychology, University of Liverpool, UK
    Eur J Dent Educ 6:22-9. 2002
    ..To determine the degree of psychological distress, the experience of emotional exhaustion, and the extent of stress associated with course work in dental students and to compare these measurements among seven European dental schools...
  77. ncbi Neuroendocrine responses to experimentally-induced psychological stress in healthy humans
    G Gerra
    Addiction Research Center, Centro Studi Farmacotossicodipendenze, Ser T, A U S L, Via Spalato 2, 43100, Parma, Italy
    Psychoneuroendocrinology 26:91-107. 2001
    Previous studies of hormonal and neurophysiological changes in response to psychological stress in humans have produced contrasting findings due to differing experimental procedures and consistent individual variability...
  78. ncbi Chronic behavioral stress induces apical dendritic reorganization in pyramidal neurons of the medial prefrontal cortex
    J J Radley
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuroscience 125:1-6. 2004
    ....
  79. doi Work-related psychosocial factors and the development of ischemic heart disease: a systematic review
    Nanna H Eller
    Clinic of Occupational Medicine, Hillerød Hospital, Hillerød, Denmark
    Cardiol Rev 17:83-97. 2009
    ..Studies involving women are too few to draw any conclusion concerning women, work stress, and IHD...
  80. ncbi Exposure to juvenile stress exacerbates the behavioural consequences of exposure to stress in the adult rat
    Avi Avital
    Department of Psychology and The Brain and Behavior Research Center, University of Haifa, Mount Carmel, Haifa, Israel
    Int J Neuropsychopharmacol 8:163-73. 2005
    ..These results indicate that an exposure to a relatively brief juvenile stressful experience has profound and long-lasting effects on the ability to cope with stress in adulthood...
  81. ncbi Gender differences in the effects from working conditions on mental health: a 4-year follow-up
    Carina Bildt
    National Institute for Working Life, 112 79 Stockholm, Sweden
    Int Arch Occup Environ Health 75:252-8. 2002
    ..Also, the relative importance of other living conditions in relation to poor mental health in 1997 was examined...
  82. ncbi Inflammatory responses to psychological stress in fatigued breast cancer survivors: relationship to glucocorticoids
    Julienne E Bower
    Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, 300 UCLA Medical Plaza, Room 3306, Box 957076 Los Angeles, CA 90095 7076, USA
    Brain Behav Immun 21:251-8. 2007
    ..05). These data provide further evidence of enhanced inflammatory processes in fatigued breast cancer survivors and suggest that these processes may stem in part from decreased glucocorticoid response to stress...
  83. ncbi Juvenile stress induces a predisposition to either anxiety or depressive-like symptoms following stress in adulthood
    Michael Tsoory
    Department of Psychology and The Brain and Behavior Research Center, University of Haifa, Mount Carmel, 31905 Haifa, Israel
    Eur Neuropsychopharmacol 17:245-56. 2007
    ..The results suggest that the presented "Juvenile stress" model may be relevant to the reported predisposition to develop both anxiety and depression following childhood trauma...
  84. pmc Positive affect and health-related neuroendocrine, cardiovascular, and inflammatory processes
    Andrew Steptoe
    International Centre for Health and Society, Department of Epidemiology and Public Health, University College London, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 102:6508-12. 2005
    ..These effects were independent of psychological distress, supporting the notion that positive well-being is directly related to health-relevant biological processes...
  85. ncbi The impact of stress on the development and expression of atopy
    Rosalind J Wright
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin Allergy Clin Immunol 5:23-9. 2005
    ..There is provocative evidence that psychological stress constitutes an increased risk for atopy...
  86. pmc Stress and inflammation in exacerbations of asthma
    Edith Chen
    University of British Columbia, Department of Psychology, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4
    Brain Behav Immun 21:993-9. 2007
    In this mini-review, we outline a model depicting the immunologic mechanisms by which psychological stress can exacerbate clinical symptoms in patients with asthma...
  87. pmc Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice
    Karin M Aberg
    Dermatology and Medical Metabolism Services, Veterans Affairs Medical Center, and Department of Dermatology, UCSF, San Francisco, California 94121, USA
    J Clin Invest 117:3339-49. 2007
    The skin is the first line of defense against microbial infection, and psychological stress (PS) has been shown to have adverse effects on cutaneous barrier function...
  88. pmc Chronic stress alters synaptic terminal structure in hippocampus
    A M Magarinos
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 94:14002-8. 1997
    ....
  89. ncbi Chronic stress impairs rat spatial memory on the Y maze, and this effect is blocked by tianeptine pretreatment
    C D Conrad
    Laboratory of Neuroendocrinology, Rockefeller University, New York 10021, USA
    Behav Neurosci 110:1321-34. 1996
    ..These data are consistent with the previously demonstrated ability of tianeptine to prevent chronic stress-induced atrophy of the CA3 dendrites...
  90. pmc Work stress, smoking status, and smoking intensity: an observational study of 46,190 employees
    Anne Kouvonen
    Department of Psychology, POB 9, FI 00014 University of Helsinki, Finland
    J Epidemiol Community Health 59:63-9. 2005
    ..To examine the relation between work stress, as indicated by the job strain model, and the effort-reward imbalance model, and smoking...
  91. ncbi Activity and plasticity in the CA1, the dentate gyrus, and the amygdala following controllable vs. uncontrollable water stress
    Alexandra Kavushansky
    Department of Psychology and Brain and Behavior Research Center, University of Haifa, Israel
    Hippocampus 16:35-42. 2006
    ..These findings provide insight into the differential effects of stress and stress controllability on different hippocampal subregions and the amygdala...
  92. ncbi Impaired memory retrieval after psychosocial stress in healthy young men
    Sabrina Kuhlmann
    Institute of Experimental Psychology, University of Duesseldorf, D 40225 Duesseldorf, Germany
    J Neurosci 25:2977-82. 2005
    ..The present study thus demonstrates that psychosocial stress impairs memory retrieval in humans and suggests that emotionally arousing material is especially sensitive to this effect...
  93. ncbi Blood pressure reactivity to psychological stress and coronary calcification in the Coronary Artery Risk Development in Young Adults Study
    Karen A Matthews
    University of Pittsburgh, Pittsburgh, PA 15213, USA
    Hypertension 47:391-5. 2006
    A longstanding hypothesis is that individuals who exhibit large increases in blood pressure during psychological stress are at risk for atherosclerosis...
  94. ncbi Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation
    P Willner
    Department of Psychology, University of Wales Swansea, UK
    Psychopharmacology (Berl) 134:319-29. 1997
    ..However, once established, the CMS model can be used to study problems that are extremely difficult to address by other means...
  95. ncbi Children's psychological responses after critical illness and exposure to invasive technology
    Janet E Rennick
    Department of Nursing Research, The Montreal Children s Hospital, McGill University Health Centre, School of Nursing, McGill University, Montreal, Quebec, Canada
    J Dev Behav Pediatr 23:133-44. 2002
    ..Findings indicate that regardless of the hospital setting, invasiveness coupled with length of stay and severity of illness in young children may have adverse long-term effects...
  96. ncbi Psychological responses of women after first-trimester abortion
    B Major
    Department of Psychology, University of California, Santa Barbara, CA 93106 USA
    Arch Gen Psychiatry 57:777-84. 2000
    ..The objectives of this study were to examine women's emotions, evaluations, and mental health after an abortion, as well as changes over time in these responses and their predictors...
  97. pmc Anxiety and depression after prostate cancer diagnosis and treatment: 5-year follow-up
    I J Korfage
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Br J Cancer 94:1093-8. 2006
    ..STAI-State can be a useful screening tool but needs further development...
  98. pmc Multiple traumatic events and psychological distress: the South Africa stress and health study
    Stacey L Williams
    Department of Psychology, East Tennessee State University, Johnson City, TN 37614, USA
    J Trauma Stress 20:845-55. 2007
    ..Individuals with the most traumas (6+) appear at 5 times greater risk of high distress. This study highlights the importance of considering traumatic events in the context of other traumas in South Africa...
  99. ncbi Role of stress in the pathogenesis of the metabolic syndrome
    Roland Rosmond
    Psychoneuroendocrinology 30:1-10. 2005
    ..In this review, we will discuss how such processes mediate a pathogenetic role in the Metabolic Syndrome...
  100. ncbi Personality traits and types predict medical school stress: a six-year longitudinal and nationwide study
    Reidar Tyssen
    Department of Behavioural Sciences in Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway
    Med Educ 41:781-7. 2007
    ..This study examines whether both personality types and traits predict stress during medical school training...
  101. ncbi Student responses to the gross anatomy laboratory in a medical curriculum
    C E Dinsmore
    Department of Anatomy, Rush Medical College, Chicago, Illinois, USA
    Clin Anat 14:231-6. 2001
    ..We offer explanations for our findings, comments on disparate results from other studies and suggestions for appropriate responses by anatomy faculty, who must address these student needs...

Research Grants83

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Transcription factors regulating sensory gene expression and pain pathways
    Eric E Turner; Fiscal Year: 2011
    ..Together these studies will significantly advance our understanding of the molecular regulation of pain receptor pathways, which may form the basis for future pain treatments. ..
  3. Principles of Therapy in Cerebellar Disease: Explorations in Ion Channel Mutants
    JOHN SAMUEL STAHL; Fiscal Year: 2013
    ....
  4. Prevention of Acute Lung Injury by IL-6 activated STAT3
    Ana Moran; Fiscal Year: 2010
    ....
  5. Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial
    BARBARA O'BRIEN; Fiscal Year: 2013
    ..Participants will be contacted annually to determine current health status. Follow up includes ascertainment of adverse medical outcomes, cancer incidence, cause of death, and mortality impact. ..
  6. Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial
    Mona Fouad; Fiscal Year: 2013
    ..Participants will be contacted annually to determine current health status. Follow up includes ascertainment of adverse medical outcomes, cancer incidence, cause of death, and mortality impact. ..
  7. Statin modulation of immunotherapy for Alzheimer disease
    Jun Tan; Fiscal Year: 2012
    ..This will be tested by comparing behavior and brain health in several mouse groups including: A( vaccinated (alone) and those treated with lovastatin plus A( vaccination. ..
  8. Role of IKK in NSCLC: Modulation of SMRT and NF-kappaB
    Marty W Mayo; Fiscal Year: 2012
    ..The overall goal of this project is use these newly identified gene products as novel therapeutic targets for detection and treatment of NSCLC. ..
  9. Inhibition of IkK to treat lethal Graft-vs.-Host Disease
    Patrick Flood; Fiscal Year: 2009
    ..Experiments are proposed in animal models to test the activity of the compound and if successful the long-term goal of this work is to take this compound in human clinical trials for the treatment of GVHD. ..
  10. Role of CD44 in experimental Multiple Sclerosis
    Mitzi Nagarkatti; Fiscal Year: 2013
    ..abstract_text> ..
  11. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..abstract_text> ..
  12. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..The proposed systems to screen a library of compounds to rescue TS phenotypes will provide a platform to find novel lead compounds that would be clinically useful for the treatment of not only TS but also other cardiac arrhythmias. ..
  13. Cellular Signaling in Alcoholism
    Subhash C Pandey; Fiscal Year: 2013
    ....
  14. Chronic Stress and Abdominal Pain: Novel Mechanisms
    John W Wiley; Fiscal Year: 2013
    ..Recent reports indicate that chronic psychological stress causes changes in epigenetic regulation of gene function in CNS regions associated with memory and mood...
  15. Pathogenesis of the Metabolic Syndrome
    W Timothy Garvey; Fiscal Year: 2013
    ..These data will predictably identify new diagnostic biomarkers for insulin resistance and T2DM, and advance our understanding of molecular mechanisms underlying human insulin resistance. ..
  16. ALTERED CARDIAC MYOCYTE SIGNALING IN DIABETIC MYOCARDIUM AND FUNCTIONAL SEQUELAE
    ANTHONY JUSTIN MUSLIN; Fiscal Year: 2010
    ..The analysis of the role of Akt2 in diabetic cardiomyopathy may lead to new therapies that may help to reduce the high mortality rate associated with diabetes. ..
  17. Efficacy of Yoga for Treatment-Resistant PTSD
    Bessel Van der Kolk; Fiscal Year: 2010
    ..adults with PTSD, and measure whether yoga can affect "the attitudes and beliefs" that "can reduce psychological stress and contribute to positive health outcomes...
  18. Novel, Rapidly Translatable Technologies for Healing Long Bone Segmental Defects
    Christopher H Evans; Fiscal Year: 2010
    ..If this project is successful, it will prevent much human suffering, enable people to return to work more quickly, and save money. ..
  19. Emergency Neurophysiological Assessment Bedside Logic Engine
    Don M Tucker; Fiscal Year: 2010
    ..Network access technology will facilitate remote review by expert neurologists, and a training protocol will provide first-responder usability for emergency technicians and physicians without training in clinical neurophysiology. ..
  20. Understanding Pain of Gastrointestinal Origin in Women that Serve in OEF/OIF
    Beverley Greenwood-Van Meerveld; Fiscal Year: 2013
    ..Moreover, we will examine whether rats exposed to ELS show altered behavioral responses to chronic stress in adulthood compared to age-matched controls ..
  21. Mechanism-Based Discovery of Protectants Against Iron-Dependant Oxidative Injury
    JUSTIN M SCHWARTZ; Fiscal Year: 2011
    ..My project proposes to better understand the role of iron mobilization from lysosomes to mitochondria in ischemia/reperfusion injury and to develop novel therapies to mitigate or eliminate damage from this condition. ..
  22. Mechanisms of Heme Transport in Macrophages
    CARINE CARINE WHITE; Fiscal Year: 2012
    ....
  23. The mechanisms by which alcohol and HIV render the lung susceptible to injury
    DAVID MARSHALL GUIDOT; Fiscal Year: 2013
    ..This research project is designed to determine how alcohol and HIV-1 interact to make the lung susceptible to injury, and to develop effective treatments that can improve the health of these vulnerable individuals. ..
  24. Non-coding RNA engineers antibody diversity
    Uttiya Basu; Fiscal Year: 2011
    ..Antibodies are polypeptide complexes produced from B-lymphocytes that are present in the bodily fluids of vertebrates, and are used by the immune system to identify and neutralize foreign antigens, such as bacteria and viruses. ..
  25. Efficacy of GABAA a5 receptor inverse agonists in learning impaired rats
    EARL MICHAEL GIBBS; Fiscal Year: 2010
    ..Patients with learning disorders and those suffering from complications due to neurodegenerative diseases will greatly benefit as PWZ-029 moves another step closer to the clinic. ..
  26. Novel Zebrafish Models to Study Toxicity of PCBs and Pesticides During Pregnancy
    Lisa Satterwhite; Fiscal Year: 2009
    ....
  27. Chronic stress mediates fat-related changes in insulin signaling and gut motility
    CHARALABOS contact POTHOULAKIS; Fiscal Year: 2010
    ..mechanisms underlying these associations are unknown, accumulating evidence clearly demonstrates chronic psychological stress as a key risk factor in this cluster of diseases...
  28. Role of Platelet derived growth factor receptor-a in Liver Patho-biology
    SATDARSHAN SINGH MONGA; Fiscal Year: 2013
    ..Thus, this highly significant proposal will unequivocally and comprehensively address the role and regulation of PDGFR[unreadable] in liver health and disease. ..
  29. Antibody-mediated Gene Therapy for the Treatment of Cancer
    TRACY RUTH DANIELS-WELLS; Fiscal Year: 2013
    ..The outstanding research environment at UCLA, the guidance from my experienced mentors, and this award will greatly facilitate my success in reaching my goals and will open a new dimension in my professional development. ..
  30. PS11-003 Minority AIDS Research Initiative
    BRIDGETTE MERCEDEZ BRAWNER; Fiscal Year: 2013
    ..Given that adolescent health is imperative to public health, the proposed research is timely, innovative and bears great significance. ..
  31. Effectivenss of a New Non-Invasive Erectile Support System in Aging Populations
    S ALEXANDER WEINSTOCK; Fiscal Year: 2012
    ....
  32. Role of ALDH7A1 in Ethanol-Induced Oxidative Damage
    CHAD NICHOLAS BROCKER; Fiscal Year: 2011
    ..This long term goal of this project is to elucidate the protective functions of ALDH7A1 during excessive alcohol consumption. ..
  33. Ca Signaling in Progression of Amyotrophic Lateral Sclerosis in Skeletal Muscle
    Jingsong Zhou; Fiscal Year: 2013
    ....
  34. Osteoclastic Protein-Tyrosine Phosphatase and Resorption
    Kin Hing William Lau; Fiscal Year: 2013
    ..This project may allow disclose novel targets for development of more effective anti-resorptive therapies for osteoporosis and related disease. Thus, this project is highly relevant to the VA patient care mission. ..
  35. Heat Shock Protein Synthesis Inhibitor Treatment of Hepatitis C Viral Infection
    SAMUEL WHEELER FRENCH; Fiscal Year: 2013
    ....
  36. Persisting Grand Mal and Myoclonic Seizures in JME including Veterans
    Antonio V Delgado-Escueta; Fiscal Year: 2013
    ..Understanding JME disease mechanisms brings an era of targeted and designer medicine, and positively impacts the mission of the VA healthcare system and the health of Veterans. ..
  37. Cellular and Molecular Regulation of Thrombopoiesis
    Ramesh A Shivdasani; Fiscal Year: 2012
    ..Characterizing key molecular pathways of platelet formation should lead to better control of circulating platelet counts and to implementation of less toxic treatments for cancer. ..
  38. A Ribozyme Rescue Strategy for Dry Age-Related Macular Degeneration
    John M Sullivan; Fiscal Year: 2013
    ..This proposed study is a proof-of-concept test of a novel gene therapy strategy for dry AMD. Success in a mouse model is a first essential step toward human clinical trials, which could be conducted in the VA system. ..
  39. Role of Dendritic Ca2+ Transients in Respiratory Rhythm Generation
    Jack L Feldman; Fiscal Year: 2010
    ..The proposed studies will significantly advance our understanding of the neural mechanisms generating respiratory rhythm and shed light on human disorders of breathing. ..
  40. Optical Molecular Tomography for Regenerative Medicine
    Ge Wang; Fiscal Year: 2013
    ..The results will potentially benefit tens of millions of patients suffering from severely damaged vascular or nervous systems, heart, kidneys, liver, skeleton, bladder, or other organs. ..
  41. Glycosaminoglycans and Cell Traffic in the Lymphatic Microenvironment
    Mark M Fuster; Fiscal Year: 2012
    ..This work may lead to novel therapy to inhibit the spread, morbidity, and mortality of cancer in our Veteran population. ..
  42. Mechanisms of Cochlear Oxidative Stress Injury and Strategies to Protect Hearing
    Michael J Brenner; Fiscal Year: 2013
    ..The long-term goal of this research is to develop safe and effective strategies to prevent hearing loss related to aminoglycoside antibiotic therapy. ..
  43. Fall risk assessment and prevention in elderly with diabetes using wearable techn
    Bor Rong Chen; Fiscal Year: 2012
    ..We propose a simple modality to measure as well as train balance strategies in patients with impairment of lower extremity perception, which provides real time visual feedback to the subject. ..
  44. Identifying underlying mechanisms of intracellular changes in response to caregiv
    MELANIE SARAH FLINT; Fiscal Year: 2013
    ..b>Psychological stress has been reported to affect several aspects of immunity including lymphocyte activation and migration...
  45. Modulation of cancer prevention by social stress
    Hildegard M Schuller; Fiscal Year: 2010
    ..Chronic psychological stress and the resulting systemic increase in stress neurotransmitters noradrenaline and adrenaline and the ..
  46. Nitric Oxide and gastric motility in female diabetics
    Pandu R Gangula; Fiscal Year: 2010
    ..Further, it may lead to the discovery of novel therapeutic targets for the management of this challenging clinical syndrome. ..
  47. Effect of Neonatal Hyperoxia on Alveolar Development and Infection
    MICHAEL A O'REILLY; Fiscal Year: 2012
    ..abstract_text> ..
  48. Studies on the virulence of Fillifactor alocis
    Hansel M Fletcher; Fiscal Year: 2013
    ..alocis. It will generatea model system(s) that will yield important clues that will facilitate the development of novel therapeutic interventions to aid in the control and prevention of periodontal disease ..
  49. Implantation of physiologically functional bioengineered innervated IAS construct
    Khalil N Bitar; Fiscal Year: 2010
    ..This has potential to provide enhanced quality of life to persons with fecal incontinence. Furthermore it would have positive implication for people suffering from urinary incontinence. ..
  50. RidCancerPain Intervention in a Hispanic Population Along the US-Mexico Border
    KRISTYNIA MARIE contact ROBINSON; Fiscal Year: 2010
    ....
  51. Novel Hematopoietic Conditioning Agents for Treatment of Hematological Diseases
    Olga B Chernova; Fiscal Year: 2010
    ..The development of hematopoietic-specific conditioning agents should provide a less toxic alternative to current regimens and, thus, has major implications for patients receiving HSCT for the treatment of hematological diseases. ..
  52. Eosinophil ORMDL3 and allergic inflammation
    P Sriramarao; Fiscal Year: 2012
    ....
  53. Functional roles of Nrf2 and NQO1 genetic variants in hyperoxic lung injury-ARDS
    Bhagavatula Moorthy; Fiscal Year: 2013
    ..g., use of PPI such as OM) for the prevention/treatment of ALI/ARDS in humans. ..
  54. Attenuating the retinal and CNS adverse effects of vigabatrin with NKCC1 inhibito
    Frances E Jensen; Fiscal Year: 2010
    ....
  55. Role of Subdiaphragmatic Vagus in Fibromyalgia Syndrome
    JON DAVID LEVINE; Fiscal Year: 2013
    ..The findings should help tailor specific therapies that may prevent or at least ameliorate their significant suffering. ..
  56. Downregulation of Rod Metabolism in Retinopathy of Prematurity
    JAMES DANIEL AKULA; Fiscal Year: 2010
    ..Thus, suppression of metabolically demanding processes in the rods promises preservation of visual function and prevention of vascular disease. ..
  57. Leptin function &resistance in midbrain VTA &SN in reward eating &obesity
    YI NONE ZHANG; Fiscal Year: 2013
    ..The long-range benefit from our study would be to reduce the ever-rising burden of long-term health care costs within the VA patient care system. ..
  58. Multiplexed DNA Origami-Based Biomarker Detection Assay for Early Dx of Arthritis
    John E Mueller; Fiscal Year: 2013
    ..g. weight loss) to increase their quality of life. Lastly, if the feasibility of the method is demonstrated, the method could be applied to other candidate biomarkers in AR. ..
  59. Development of Novel LANCL2-based Anti-diabetic Compounds
    JOSEP BASSAGANYA; Fiscal Year: 2013
    ..3 million estimated to be over $12.5 Billion for prescription medication costs alone annually in the US. ..
  60. Estradiol-Induced Sialyation Of NCAM Prevents Leucocyte:Endothelial Adhesion
    Frederick Naftolin; Fiscal Year: 2010
    ..This proposal may improve the application of anti-atherosclerosis agents and lead to development of new agents to protect blood vessels from atherosclerosis and its complications. ..
  61. Derivation of cerebral cortical GABAergic interneurons from human iPS cells
    Lorenz P Studer; Fiscal Year: 2010
    ....
  62. TNF-Mediated Tumor Promotion: The Role of Vascular Leukocytes
    Pampee P Young; Fiscal Year: 2011
    ..Cancer continues to be a pervasive and prevalent health problem among our aging Veterans and critical to the biomedical research mission of the Veterans Affairs. ..
  63. Mechanisms of structural plasticity in stress-related disorders
    Scott J Russo; Fiscal Year: 2013
    ..Based on the results thus far, we believe that chronic physical and psychological stress-induced changes in spine density underlie certain aspects of the social defeat behavioral syndrome...
  64. Non-intrusive Locomotion and Gait Stability Analysis Monitoring System for the El
    Sunil Saxena; Fiscal Year: 2007
    ..Human subjects testing in collaboration with Virginia Tech will be conducted during Phase I to demonstrate feasibility. [unreadable] [unreadable] [unreadable] [unreadable]..
  65. Autologous EPC lining to improve biocompatibility of circulatory assist devices
    Jeffrey H Lawson; Fiscal Year: 2010
    ..These could become resistant to in-stent restenosis and benefit millions of Americans who are being treated with coronary or vascular stents. ..
  66. Contractile Hydrogel Dressing for Primary Wound Closure
    Aristidis Veves; Fiscal Year: 2010
    ....
  67. Novel RNAi Inhibits Both Inflammation and Bone Resorption in Oral Diseases
    Yi Ping Li; Fiscal Year: 2010
    ..Such translational application of Atp6i TIRC7 gene silencing strategies would save an enormous amount of money and time spent on repairing the severe gum and bone defects. 1 ..
  68. ATYPICAL ODONTALGIA AND ENDODONTIC TREATMENT, SENSORY TESTING AND GENETIC STUDY
    Eli Eliav; Fiscal Year: 2010
    ..This exploratory study results may serve as the ground for a further study that will evaluate more patients prior to the procedure, will study predisposing factors and will help predict treatment outcome. ..
  69. Micro-patterned surfaces for reducing the risk of catheter-associated UTI
    SHRAVANTHI REDDY; Fiscal Year: 2009
    ....
  70. Stress, Cellular Aging and Susceptibility to Infectious Disease
    Sheldon A Cohen; Fiscal Year: 2010
    ..Loss of telomere length may be especially important in understanding the role of psychological stress in infectious illness...
  71. MECHANISM OF LATENCY OF HERPES SIMPLEX VIRUS
    Nigel Fraser; Fiscal Year: 2007
    ..These studies will continue our investigation of herpes simplex virus latency and reactivation and further our understanding of the mechanism of latency in the peripheral nervous system. ..
  72. National Lung Screening Trial (NLST)
    Cheryl Robinson; Fiscal Year: 2009
    ..Participants will be contacted annually to determine current health status. Follow up includes ascertainment of adverse medical outcomes, cancer incidence, cause of death, and mortality impact. ..
  73. National Lung Study Trial
    Douglas Reding; Fiscal Year: 2009
    ..Participants will be contacted annually to determine current health status. Follow up includes ascertainment of adverse medical outcomes, cancer incidence, cause of death, and mortality impact. ..
  74. Brain changes in tinnitus
    Josef P Rauschecker; Fiscal Year: 2010
    ..These results would guide tinnitus research into a new direction and open up a new point of intervention by emphasizing the modulatory role of extra-auditory structures responsible for the direction of attention. ..
  75. LUNG DRUG DELIVERY WITH CARBON DIOXIDE AEROSOL INHALERS
    Brian Hansen; Fiscal Year: 2009
    ....
  76. Experimental Model For Pressure Ulcers In Human Skin: The Role of Aging and ECM
    Marjana Tomic Canic; Fiscal Year: 2009
    ..An experimental model for pressure ulcers will not only provide an understanding of the underlying mechanisms of pathogenesis, but also allow for pre- clinical testing of potential therapeutic modalities. ..
  77. Modular internalizing molecules for treatment of more than one stage of malignanc
    Michael Lawrence Greenberg; Fiscal Year: 2010
    ....
  78. The Role of Stress Induced Hypoxia in Periodontitis
    PRAVEEN GAJENDRAREDDY; Fiscal Year: 2009
    Project Summary Periodontal disease is one of the major causes of tooth loss in the world. Although psychological stress is known to aggravate periodontal pathology, the exact mechanisms remain to be elucidated...
  79. Wireless Multichannel Electrocorticogram Recording for Epilepsy Monitoring
    Stuart Cogan; Fiscal Year: 2009
    ..The wireless arrays will benefit patients with intractable epilepsy whose seizures are not well-controlled by medication. ..
  80. Web-Based Training in Eating Disorder Prevention for Dental Professionals
    Herbert Severson; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..