consciousness

Summary

Summary: Sense of awareness of self and of the environment.

Top Publications

  1. ncbi Attention and consciousness: two distinct brain processes
    Christof Koch
    Division of Biology 216 76, California Institute of Technology, Pasadena, CA 91125, USA
    Trends Cogn Sci 11:16-22. 2007
  2. ncbi Towards a cognitive neuroscience of consciousness: basic evidence and a workspace framework
    S Dehaene
    Unité INSERM 334, Service Hospitalier Frederic Joliot, CEA DRM DSV, 4, place du General Leclerc, 91401 Cedex, Orsay, France
    Cognition 79:1-37. 2001
  3. ncbi A sensorimotor account of vision and visual consciousness
    J K O'Regan
    Laboratoire de Psychologie Experimentale, Centre National de Recherche Scientifique, Universite Rene Descartes, 92774 Boulogne Billancourt, France
    Behav Brain Sci 24:939-73; discussion 973-1031. 2001
  4. pmc Default network connectivity reflects the level of consciousness in non-communicative brain-damaged patients
    Audrey Vanhaudenhuyse
    Coma Science Group, Cyclotron Research Centre, University of Liege, Allee du 6 Aout, B30, Liege, Belgium
    Brain 133:161-71. 2010
  5. ncbi Consciousness and complexity
    G Tononi
    Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, CA 92121, USA
    Science 282:1846-51. 1998
  6. pmc A neuronal network model linking subjective reports and objective physiological data during conscious perception
    Stanislas Dehaene
    Institut National de la Sante et de la Recherche Medicale, Unité 562, Cognitive Neuroimaging, Institut Fédératif de Recherche 49, Service Hospitalier Frederic Joliot, Commissariat à l Energie Atomique DSV, 91401 Orsay Cedex, France
    Proc Natl Acad Sci U S A 100:8520-5. 2003
  7. doi Attitudes towards end-of-life issues in disorders of consciousness: a European survey
    A Demertzi
    Coma Science Group, Cyclotron Research Centre, University of Liege, Allée du 6 août no 8, Sart Tilman B30, 4000, Liege, Belgium
    J Neurol 258:1058-65. 2011
  8. ncbi Conflict, consciousness, and control
    Ulrich Mayr
    Department of Psychology, University of Oregon, Eugene, OR 97403, USA
    Trends Cogn Sci 8:145-8. 2004
  9. ncbi The neural correlate of (un)awareness: lessons from the vegetative state
    Steven Laureys
    Cyclotron Research Center and Department of Neurology, University of Liege, Sart Tilman B30, 4000 Liege, Belgium
    Trends Cogn Sci 9:556-9. 2005
  10. ncbi Competition for consciousness among visual events: the psychophysics of reentrant visual processes
    V Di Lollo
    Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
    J Exp Psychol Gen 129:481-507. 2000

Detail Information

Publications380 found, 100 shown here

  1. ncbi Attention and consciousness: two distinct brain processes
    Christof Koch
    Division of Biology 216 76, California Institute of Technology, Pasadena, CA 91125, USA
    Trends Cogn Sci 11:16-22. 2007
    The close relationship between attention and consciousness has led many scholars to conflate these processes...
  2. ncbi Towards a cognitive neuroscience of consciousness: basic evidence and a workspace framework
    S Dehaene
    Unité INSERM 334, Service Hospitalier Frederic Joliot, CEA DRM DSV, 4, place du General Leclerc, 91401 Cedex, Orsay, France
    Cognition 79:1-37. 2001
    ..to clarify the philosophical, empirical, and theoretical bases on which a cognitive neuroscience approach to consciousness can be founded...
  3. ncbi A sensorimotor account of vision and visual consciousness
    J K O'Regan
    Laboratoire de Psychologie Experimentale, Centre National de Recherche Scientifique, Universite Rene Descartes, 92774 Boulogne Billancourt, France
    Behav Brain Sci 24:939-73; discussion 973-1031. 2001
    ..that it leaves unexplained how the existence of such a detailed internal representation might produce visual consciousness. An alternative proposal is made here. We propose that seeing is a way of acting...
  4. pmc Default network connectivity reflects the level of consciousness in non-communicative brain-damaged patients
    Audrey Vanhaudenhuyse
    Coma Science Group, Cyclotron Research Centre, University of Liege, Allee du 6 Aout, B30, Liege, Belgium
    Brain 133:161-71. 2010
    ..connectivity pattern in the default network would differ in different pathological alterations of consciousness. Fourteen non-communicative brain-damaged patients and 14 healthy controls participated in the study...
  5. ncbi Consciousness and complexity
    G Tononi
    Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, CA 92121, USA
    Science 282:1846-51. 1998
    Conventional approaches to understanding consciousness are generally concerned with the contribution of specific brain areas or groups of neurons...
  6. pmc A neuronal network model linking subjective reports and objective physiological data during conscious perception
    Stanislas Dehaene
    Institut National de la Sante et de la Recherche Medicale, Unité 562, Cognitive Neuroimaging, Institut Fédératif de Recherche 49, Service Hospitalier Frederic Joliot, Commissariat à l Energie Atomique DSV, 91401 Orsay Cedex, France
    Proc Natl Acad Sci U S A 100:8520-5. 2003
    ..This all-or-none dynamics of conscious perception was verified behaviorally in human subjects...
  7. doi Attitudes towards end-of-life issues in disorders of consciousness: a European survey
    A Demertzi
    Coma Science Group, Cyclotron Research Centre, University of Liege, Allée du 6 août no 8, Sart Tilman B30, 4000, Liege, Belgium
    J Neurol 258:1058-65. 2011
    ..A 16-item questionnaire related to consciousness, pain and end-of-life issues in chronic (i.e...
  8. ncbi Conflict, consciousness, and control
    Ulrich Mayr
    Department of Psychology, University of Oregon, Eugene, OR 97403, USA
    Trends Cogn Sci 8:145-8. 2004
    ..Along with other recent results, these findings have important implications for theories on the relationship between ACC, consciousness, and cognitive control.
  9. ncbi The neural correlate of (un)awareness: lessons from the vegetative state
    Steven Laureys
    Cyclotron Research Center and Department of Neurology, University of Liege, Sart Tilman B30, 4000 Liege, Belgium
    Trends Cogn Sci 9:556-9. 2005
    b>Consciousness has two main components: wakefulness and awareness. The vegetative state is characterized by wakefulness without awareness...
  10. ncbi Competition for consciousness among visual events: the psychophysics of reentrant visual processes
    V Di Lollo
    Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
    J Exp Psychol Gen 129:481-507. 2000
    ..The model provides a more comprehensive account of all forms of visual masking than do the long-held feed-forward views based on inhibitory contour interactions...
  11. pmc Interrupting the "stream of consciousness": an fMRI investigation
    Kristen A McKiernan
    Olin Neuropsychiatry Research Center, The Institute of Living, Hartford, CT 06106, USA
    Neuroimage 29:1185-91. 2006
    ..79, P < 0.05 corrected). As these regions have been implicated in semantic processing and self-referential thought, the findings support the suspension of internal cognitive processing as one mechanism for TID...
  12. ncbi Affective consciousness: Core emotional feelings in animals and humans
    Jaak Panksepp
    Department of Psychology, Bowling Green State University, Bowling Green, OH 43403, USA
    Conscious Cogn 14:30-80. 2005
    ..In coarse form, primary process affective consciousness seems to be fundamentally an unconditional "gift of nature" rather than an acquired skill, even though those ..
  13. ncbi Towards a true neural stance on consciousness
    Victor A F Lamme
    Department of Psychology, University of Amsterdam, Roeterstraat 15, 1018 WB Amsterdam, The Netherlands
    Trends Cogn Sci 10:494-501. 2006
    b>Consciousness is traditionally defined in mental or psychological terms. In trying to find its neural basis, introspective or behavioral observations are considered the gold standard, to which neural measures should be fitted...
  14. ncbi A framework for consciousness
    Francis Crick
    Francis Crick is at the Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, California 92037, USA
    Nat Neurosci 6:119-26. 2003
    Here we summarize our present approach to the problem of consciousness. After an introduction outlining our general strategy, we describe what is meant by the term 'framework' and set it out under ten headings...
  15. ncbi Consciousness as integrated information: a provisional manifesto
    Giulio Tononi
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin, USA
    Biol Bull 215:216-42. 2008
    ..information theory (IIT) starts from phenomenology and makes use of thought experiments to claim that consciousness is integrated information...
  16. doi Preserved feedforward but impaired top-down processes in the vegetative state
    Melanie Boly
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liège and CHU Sart Tilman Hospital, 4000 Liege, Belgium
    Science 332:858-62. 2011
    ..and the generation of long-latency electrophysiological responses, might provide a more reliable correlate of consciousness in severely brain-damaged patients, than frontoparietal responses...
  17. ncbi Toward a theory of episodic memory: the frontal lobes and autonoetic consciousness
    M A Wheeler
    Rotman Research Institute of Baycrest Centre, Toronto, Ontario, Canada
    Psychol Bull 121:331-54. 1997
    ..that the prefrontal cortex plays a critical, supervisory role in empowering healthy adults with autonoetic consciousness-the capacity to mentally represent and become aware of subjective experiences in the past, present, and future...
  18. pmc Changes in resting neural connectivity during propofol sedation
    Emmanuel A Stamatakis
    Division of Anaesthesia, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 5:e14224. 2010
    ..It has been argued that the posterior cingulate is important in consciousness/awareness, but previous investigations of resting interactions between the posterior cingulate cortex and ..
  19. doi Empirical support for higher-order theories of conscious awareness
    Hakwan Lau
    Department of Psychology, Columbia University, NY 10027, USA
    Trends Cogn Sci 15:365-73. 2011
    Higher-order theories of consciousness argue that conscious awareness crucially depends on higher-order mental representations that represent oneself as being in particular mental states...
  20. pmc Measuring consciousness: relating behavioural and neurophysiological approaches
    Anil K Seth
    Department of Informatics, University of Sussex, Falmer, Brighton, BN1 9QJ, UK
    Trends Cogn Sci 12:314-21. 2008
    The resurgent science of consciousness has been accompanied by a recent emphasis on the problem of measurement...
  21. doi Consciousness cannot be separated from function
    Michael A Cohen
    Vision Sciences Laboratory, Department of Psychology, William James Hall, Harvard University, Cambridge, MA 02138, USA
    Trends Cogn Sci 15:358-64. 2011
    Numerous theories of consciousness hold that there are separate neural correlates of conscious experience and cognitive function, aligning with the assumption that there are 'hard' and 'easy' problems of consciousness...
  22. doi The attentional requirements of consciousness
    Michael A Cohen
    Department of Psychology, Harvard University, William James Hall, 33 Kirkland Street Cambridge, MA 02138, USA
    Trends Cogn Sci 16:411-7. 2012
    ..When this type of analysis is performed, the evidence is fully consistent with a model in which attention is necessary, but not sufficient, for awareness...
  23. ncbi Detecting awareness in the vegetative state
    Adrian M Owen
    Medical Research Council Cognition and Brain Sciences Unit, Cambridge CB2 2EF, UK
    Science 313:1402. 2006
    ..When asked to imagine playing tennis or moving around her home, the patient activated predicted cortical areas in a manner indistinguishable from that of healthy volunteers...
  24. ncbi Long-distance feedback projections to area V1: implications for multisensory integration, spatial awareness, and visual consciousness
    Simon Clavagnier
    INSERM U371, IFR19 corrected Université Claude Bernard Lyon 1, Bron, France
    Cogn Affect Behav Neurosci 4:117-26. 2004
    ..by areas that belong to the ventral visual stream, could play an important role in early multisensory integration and spatial awareness and could provide the physical substrate for the involvement of area V1 in visual consciousness.
  25. doi Memory, autonoetic consciousness, and the self
    Hans J Markowitsch
    Physiological Psychology, University of Bielefeld, Bielefeld, Germany
    Conscious Cogn 20:16-39. 2011
    ..EAM, autonoetic consciousness and the self are intimately linked, grounding, supporting and enriching each other's development and ..
  26. doi How rich is consciousness? The partial awareness hypothesis
    Sid Kouider
    Laboratoire de Sciences Cognitives and Psycholinguistique, Ecole Normale Supérieure CNRS, 29 rue d Ulm, 75005, Paris, France
    Trends Cogn Sci 14:301-7. 2010
    Current theories of consciousness posit a dissociation between 'phenomenal' consciousness (rich) and 'access' consciousness (limited)...
  27. ncbi Global workspace theory of consciousness: toward a cognitive neuroscience of human experience
    Bernard J Baars
    The Neurosciences Institute, 10640 John Jay Hopkins Dv, San Diego, CA 92121, USA
    Prog Brain Res 150:45-53. 2005
    ..is also implicated in unconscious states, including deep sleep, coma, vegetative states, epileptic loss of consciousness, and general anesthesia...
  28. ncbi How do you feel? Interoception: the sense of the physiological condition of the body
    A D Craig
    Nat Rev Neurosci 3:655-66. 2002
    ..This system constitutes a representation of 'the material me', and might provide a foundation for subjective feelings, emotion and self-awareness...
  29. ncbi Schizophrenia, consciousness, and the self
    Louis A Sass
    Department of Clinical Psychology, Center for Cognitive Science, Rutgers University, Piscataway, NJ, USA
    Schizophr Bull 29:427-44. 2003
    ..By contrast, this article proposes a unifying account emphasizing basic abnormalities of consciousness that underlie and also antecede a disparate assortment of signs and symptoms...
  30. doi Causal role of prefrontal cortex in the threshold for access to consciousness
    A Del Cul
    INSERM, Cognitive Neuroimaging Unit, Saclay, France
    Brain 132:2531-40. 2009
    ..In all conditions of temporal or spatial attention cueing, the threshold for access to consciousness was systematically shifted in patients, particular after a lesion of the left anterior PFC...
  31. pmc Levels of processing during non-conscious perception: a critical review of visual masking
    Sid Kouider
    Laboratoire des Sciences Cognitives et Psycholinguistique, EHESS CNRS ENS, 75230 Paris, France Cognitive Neuroimaging Unit, INSERM U562, SHFJ, CEA DSV, 91401 Orsay, France
    Philos Trans R Soc Lond B Biol Sci 362:857-75. 2007
    ..We conclude by arguing that for a stimulus to reach consciousness, two factors are jointly needed: (i) the input stimulus must have enough strength (which can be prevented by ..
  32. pmc Brain dynamics underlying the nonlinear threshold for access to consciousness
    Antoine Del Cul
    INSERM, Cognitive Neuroimaging Unit, IFR 49, Saclay, France
    PLoS Biol 5:e260. 2007
    ....
  33. doi Measuring consciousness: is one measure better than the other?
    Kristian Sandberg
    Cognitive Neuroscience Research Unit, Hammel Neurorehabilitation and Research Center, Denmark
    Conscious Cogn 19:1069-78. 2010
    ..Similarities and differences between scales are discussed in the light of consciousness theories and response strategies.
  34. doi Breakdown of within- and between-network resting state functional magnetic resonance imaging connectivity during propofol-induced loss of consciousness
    Pierre Boveroux
    Department of Anesthesia and Intensive Care Medicine, University of Liege, Liege, Belgium
    Anesthesiology 113:1038-53. 2010
    Mechanisms of anesthesia-induced loss of consciousness remain poorly understood...
  35. doi A model for memory systems based on processing modes rather than consciousness
    Katharina Henke
    University of Bern, Muesmattstrasse 45, 3000 Bern 9, Switzerland
    Nat Rev Neurosci 11:523-32. 2010
    ..between different aspects of an event which, according to these models, depends on the hippocampus and on consciousness. However, recent evidence indicates that the hippocampus mediates rapid associative learning with and without ..
  36. doi Multisensory brain mechanisms of bodily self-consciousness
    Olaf Blanke
    Center for Neuroprosthetics, School of Life Sciences, Ecole Polytechnique Federale de Lausanne, Switzerland
    Nat Rev Neurosci 13:556-71. 2012
    Recent research has linked bodily self-consciousness to the processing and integration of multisensory bodily signals in temporoparietal, premotor, posterior parietal and extrastriate cortices...
  37. pmc Rhythms of consciousness: binocular rivalry reveals large-scale oscillatory network dynamics mediating visual perception
    Sam M Doesburg
    Psychophysics and Cognitive Neuroscience Laboratory, Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 4:e6142. 2009
    b>Consciousness has been proposed to emerge from functionally integrated large-scale ensembles of gamma-synchronous neural populations that form and dissolve at a frequency in the theta band...
  38. ncbi Exploring "fringe" consciousness: the subjective experience of perceptual fluency and its objective bases
    Rolf Reber
    Department of Psychology, University of Bergen, Christiesgate 12, N 5015 Bergen, Norway
    Conscious Cogn 13:47-60. 2004
    ..Both contrast and font influenced subjective fluency. These findings suggest that speed of processing at different stages condensed into a unified subjective experience of perceptual fluency...
  39. ncbi The precuneus and consciousness
    Andrea E Cavanna
    Institute of Neurology, Queen Square, London, United Kingdom
    CNS Spectr 12:545-52. 2007
    ..neuropsychiatric disorders (ie, epilepsy, Alzheimer's disease, and schizophrenia) characterized by impaired consciousness. These findings, along with the widespread connectivity pattern, suggest that the precuneus may play a central ..
  40. doi Cognitive processes in disorders of consciousness as revealed by EEG time-frequency analyses
    R Fellinger
    Department of Psychology, Laboratory for Sleep and Consciousness Research and Division of Physiological Psychology, University of Salzburg, Hellbrunnerstraße 34, 5020 Salzburg, Austria
    Clin Neurophysiol 122:2177-84. 2011
    Although behavioral evaluation of awareness in disorders of consciousness is difficult it remains the clinical standard. We believe that the refinement of EEG and analyses techniques would improve our characterization of those patients.
  41. doi Distilling the neural correlates of consciousness
    Jaan Aru
    Max Planck Institute for Brain Research, Deutschordnerstrasse 46, Frankfurt am Main, Germany
    Neurosci Biobehav Rev 36:737-46. 2012
    Solving the problem of consciousness remains one of the biggest challenges in modern science...
  42. ncbi Conduction pathways in microtubules, biological quantum computation, and consciousness
    Stuart Hameroff
    Department of Anesthesiology and Psychology, Center for Consciousness Studies, University of Arizona, Tucson, AZ 85721, USA
    Biosystems 64:149-68. 2002
    ..The Penrose-Hameroff 'Orch OR' model of consciousness is reviewed as an example of the possible utility of quantum computation in MTs.
  43. pmc The default mode network and altered consciousness in epilepsy
    Nathan B Danielson
    Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8018, USA
    Behav Neurol 24:55-65. 2011
    ..this same network has been shown to be selectively impaired during epileptic seizures associated with loss of consciousness. Using a wide range of neuroimaging and electrophysiological modalities, decreased activity in the default ..
  44. doi Perceptual consciousness overflows cognitive access
    Ned Block
    Department of Philosophy, New York University, 5 Washington Place, New York, NY 10003, USA
    Trends Cogn Sci 15:567-75. 2011
    ..issues concerning the foundations of conscious perception centers on the question of whether perceptual consciousness is rich or sparse...
  45. ncbi The medial temporal lobe distinguishes old from new independently of consciousness
    Sander M Daselaar
    Swammerdam Institute for Life Sciences, University of Amsterdam, Faculty of Science, 1098 SM Amsterdam, The Netherlands
    J Neurosci 26:5835-9. 2006
    ..These findings indicate that participants' behavior reflected the combined effects of multiple MTL regions. More generally, our results show that parts of MTL can distinguish old from new independently of consciousness.
  46. ncbi Consciousness
    J R Searle
    Department of Philosophy, University of California, Berkeley 94720 2390, USA
    Annu Rev Neurosci 23:557-78. 2000
    Until recently, most neuroscientists did not regard consciousness as a suitable topic for scientific investigation...
  47. pmc Converging intracranial markers of conscious access
    Raphael Gaillard
    INSERM, Cognitive Neuro Imaging Unit, Institut Fédé ratif de Recherche IFR 49, Gif sur Yvette, France
    PLoS Biol 7:e61. 2009
    ..These results have a direct impact on current theoretical discussions concerning the neural correlates of conscious access...
  48. ncbi Synchronization of neural activity across cortical areas correlates with conscious perception
    Lucia Melloni
    Laboratorio de Neurociencias, Escuela de Psicologia, Pontificia Universidad Catolica de Chile, Vicuña Mackenna 4860, San Joaquin, 8940000 Santiago, Chile
    J Neurosci 27:2858-65. 2007
    ..We propose that the critical process mediating the access to conscious perception is the early transient global increase of phase synchrony of oscillatory activity in the gamma frequency range...
  49. doi Dissociating consciousness from inhibitory control: evidence for unconsciously triggered response inhibition in the stop-signal task
    Simon van Gaal
    Cognitive Neuroscience Group, Department of Psychology, University of Amsterdam, Roetersstraat 15, Amsterdam 1018 WB, The Netherlands
    J Exp Psychol Hum Percept Perform 35:1129-39. 2009
    Theories about the functional relevance of consciousness commonly posit that higher order cognitive control functions, such as response inhibition, require consciousness...
  50. pmc Integrated information in discrete dynamical systems: motivation and theoretical framework
    David Balduzzi
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin, USA
    PLoS Comput Biol 4:e1000091. 2008
    ..is motivated by the observation that integrated information captures two key phenomenological properties of consciousness: (i) there is a large repertoire of conscious experiences so that, when one particular experience occurs, it ..
  51. pmc A theoretical basis for standing and traveling brain waves measured with human EEG with implications for an integrated consciousness
    Paul L Nunez
    Department of Biomedical Engineering, Tulane University and Brain Physics LLC, Brain Physics LLC, 162 Bertel Drive, Covington, LA 70433, USA
    Clin Neurophysiol 117:2424-35. 2006
    ....
  52. ncbi The precuneus: a review of its functional anatomy and behavioural correlates
    Andrea E Cavanna
    Institute of Neurology, Queen Square, London WC1N3BG, UK
    Brain 129:564-83. 2006
    ..recently been proposed that precuneus is involved in the interwoven network of the neural correlates of self-consciousness, engaged in self-related mental representations during rest...
  53. doi The directionality and functional organization of frontoparietal connectivity during consciousness and anesthesia in humans
    UnCheol Lee
    Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA
    Conscious Cogn 18:1069-78. 2009
    ..We demonstrate that directed feedback connectivity is diminished with loss of consciousness and returns with responsiveness to verbal command...
  54. ncbi Neural correlates of first-person perspective as one constituent of human self-consciousness
    K Vogeley
    Research Center Juelich University of Bonn, Germany
    J Cogn Neurosci 16:817-27. 2004
    ..perspective (3PP), which enables us to take the viewpoint of someone else, is constitutive for human self-consciousness. At the underlying representational or cognitive level, these operations are processed in an egocentric ..
  55. pmc Baseline brain energy supports the state of consciousness
    Robert G Shulman
    Magnetic Resonance Research Center, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 106:11096-101. 2009
    ..conscious state empirically by the behavioral ability to respond meaningfully to stimuli, whereas the loss of consciousness is defined by unresponsiveness...
  56. pmc Opposing effects of attention and consciousness on afterimages
    Jeroen J A van Boxtel
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 107:8883-8. 2010
    The brain's ability to handle sensory information is influenced by both selective attention and consciousness. There is no consensus on the exact relationship between these two processes and whether they are distinct...
  57. doi Dissociable network properties of anesthetic state transitions
    UnCheol Lee
    Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan 48109 5048, USA
    Anesthesiology 114:872-81. 2011
    ..It is still unknown whether anesthetic state transitions are continuous or binary. Mathematical graph theory is one method by which to assess whether brain networks change gradually or abruptly upon anesthetic induction and emergence...
  58. doi Central thalamic contributions to arousal regulation and neurological disorders of consciousness
    Nicholas D Schiff
    Laboratory of Cognitive Neuromodulation, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA
    Ann N Y Acad Sci 1129:105-18. 2008
    ..of the central thalamus to normal mechanisms of arousal regulation and to neurological disorders of consciousness. Forebrain arousal is regulated by ascending influences from brainstem/basal forebrain neuronal populations ("..
  59. pmc Ongoing spontaneous activity controls access to consciousness: a neuronal model for inattentional blindness
    Stanislas Dehaene
    INSERM CEA Unit 562, Cognitive Neuroimaging, Service Hospitalier Frederic Joliot, Orsay, France
    PLoS Biol 3:e141. 2005
    ..We relate those properties to experimental observations on the neural bases of endogenous states of consciousness, and particularly the blocking of access to consciousness that occurs in the psychophysical phenomenon of "..
  60. doi Anterior cingulate activity and the self in disorders of consciousness
    Pengmin Qin
    Laboratory for Higher Brain Function, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China
    Hum Brain Mapp 31:1993-2002. 2010
    ..this study was to investigate the relationship between medial cortical activation and the presence of self and consciousness in healthy subjects and patients with vegetative state and minimally conscious state using functional magnetic ..
  61. ncbi Introspective physicalism as an approach to the science of consciousness
    A I Jack
    Department of Psychology, Institute of Cognitive Neuroscience, University College London, Alexandra House, 17 Queen Square, WC1N 3AR, London, UK
    Cognition 79:161-96. 2001
    Most 'theories of consciousness' are based on vague speculations about the properties of conscious experience. We aim to provide a more solid basis for a science of consciousness...
  62. pmc Looking at the label and beyond: the effects of calorie labels, health consciousness, and demographics on caloric intake in restaurants
    Brenna Ellison
    University of Illinois at Urbana Champaign, 321 Mumford Hall, 1301 W, Gregory Dr, Urbana, IL 61801, USA
    Int J Behav Nutr Phys Act 10:21. 2013
    ....
  63. doi Returning from oblivion: imaging the neural core of consciousness
    Jaakko W Långsjö
    Turku PET Centre, University of Turku and Turku University Hospital, FI 20521 Turku, Finland
    J Neurosci 32:4935-43. 2012
    One of the greatest challenges of modern neuroscience is to discover the neural mechanisms of consciousness and to explain how they produce the conscious state...
  64. doi From unresponsive wakefulness to minimally conscious PLUS and functional locked-in syndromes: recent advances in our understanding of disorders of consciousness
    Marie Aurelie Bruno
    Coma Science Group, Neurology Department and Cyclotron Research Centre, University Hospital and University of Liège, Liege, Belgium
    J Neurol 258:1373-84. 2011
    ..severely brain damaged patients may show residual cortical processing in the absence of behavioural signs of consciousness. Given these new findings, the diagnostic errors and their potential effects on treatment as well as concerns ..
  65. doi Spatiotemporal reconfiguration of large-scale brain functional networks during propofol-induced loss of consciousness
    Manuel S Schröter
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Neurosci 32:12832-40. 2012
    ..whole-brain functional connectivity of 11 healthy volunteers during wakefulness and propofol-induced loss of consciousness (PI-LOC)...
  66. pmc Attention increases the temporal precision of conscious perception: verifying the Neural-ST Model
    Srivas Chennu
    Centre for Cognitive Neuroscience and Cognitive Systems, University of Kent, Canterbury, United Kingdom
    PLoS Comput Biol 5:e1000576. 2009
    ....
  67. doi The distinction between intuition and guessing in the SRT task generation: a reply to Norman and Price
    Qiufang Fu
    State Key Laboratory of Brain and Cognitive Science, Institute of Psychology, Chinese Academy of Sciences, China
    Conscious Cogn 19:478-80. 2010
    ..We present further evidence here that triplets associated with intuition but not guessing were also processed fluently...
  68. pmc Naturalizing consciousness: a theoretical framework
    Gerald M Edelman
    Neurosciences Institute, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 100:5520-4. 2003
    b>Consciousness has a number of apparently disparate properties, some of which seem to be highly complex and even inaccessible to outside observation...
  69. ncbi Measuring unconscious knowledge: distinguishing structural knowledge and judgment knowledge
    Zoltan Dienes
    Department of Psychology, University of Sussex, Brighton, UK
    Psychol Res 69:338-51. 2005
    ..The dissociations validate the use of these subjective measures of conscious awareness...
  70. doi Cortical and subcortical connectivity changes during decreasing levels of consciousness in humans: a functional magnetic resonance imaging study using propofol
    Roisin Ni Mhuircheartaigh
    Centre for Functional Magnetic Resonance of the Brain FMRIB, Department of Clinical Neurology and Nuffield Department of Anaesthetics, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    J Neurosci 30:9095-102. 2010
    While ubiquitous, pharmacological manipulation of consciousness remains poorly defined and incompletely understood (Prys-Roberts, 1987)...
  71. doi Tracking the processes behind conscious perception: a review of event-related potential correlates of visual consciousness
    Henry Railo
    Department of Psychology, University of Turku, 20014 Turku, Finland
    Conscious Cogn 20:972-83. 2011
    ..Variability of the proposed ERP correlates of consciousness is considerable: the earliest proposed ERP correlate of consciousness (P1) coincides with sensory processes ..
  72. doi Neuronal discharges and gamma oscillations explicitly reflect visual consciousness in the lateral prefrontal cortex
    Theofanis I Panagiotaropoulos
    Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tubingen, Germany
    Neuron 74:924-35. 2012
    ..However, it is not clear whether visual consciousness should be uniquely localized in the temporal association cortex...
  73. doi Unconscious structural knowledge of tonal symmetry: Tang poetry redefines limits of implicit learning
    Shan Jiang
    School of Psychology and Cognitive Science, East China Normal University, Shanghai, China
    Conscious Cogn 21:476-86. 2012
    ..We show, using artificial poetry to control both n-gram structure and repetition patterns, that people can implicitly learn to discriminate inversions from non-inversions, presenting a challenge to existing models of implicit learning...
  74. ncbi Early neural correlates of conscious somatosensory perception
    Satu Palva
    BioMag Laboratory, Engineering Centre, Helsinki University Central Hospital, FIN 00029 Helsinki, Finland
    J Neurosci 25:5248-58. 2005
    ....
  75. ncbi The entwined mysteries of anesthesia and consciousness: is there a common underlying mechanism?
    Stuart R Hameroff
    Department of Anesthesiology, The University of Arizona, Tucson, Arizona 85718, USA
    Anesthesiology 105:400-12. 2006
  76. doi Propofol induction reduces the capacity for neural information integration: implications for the mechanism of consciousness and general anesthesia
    UnCheol Lee
    Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI 48109 0048, USA
    Conscious Cogn 18:56-64. 2009
    ..0001). Furthermore, we demonstrate that loss of consciousness is reflected by the breakdown of the spatiotemporal organization of gamma waves...
  77. ncbi Post-decision wagering objectively measures awareness
    Navindra Persaud
    Department of Experimental Psychology, South Parks Road, Oxford OX1 3UD, UK
    Nat Neurosci 10:257-61. 2007
    ..Post-decision wagering may be used to study the neural correlates of consciousness.
  78. ncbi Emotion and consciousness
    Naotsugu Tsuchiya
    California Institute of Technology, HSS 228 77, Caltech, Pasadena, CA 91125, USA
    Trends Cogn Sci 11:158-67. 2007
    b>Consciousness and emotion feature prominently in our personal lives, yet remain enigmatic...
  79. doi Coma and consciousness: paradigms (re)framed by neuroimaging
    Steven Laureys
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University and University Hospital of Liège, 4000 Liege, Belgium
    Neuroimage 61:478-91. 2012
    ..provided an unprecedented collection of discoveries that bear upon our scientific understanding of recovery of consciousness in the human brain following severe brain damage...
  80. doi The neural correlates of consciousness: an update
    Giulio Tononi
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin, USA
    Ann N Y Acad Sci 1124:239-61. 2008
    This review examines recent advances in the study of brain correlates of consciousness. First, we briefly discuss some useful distinctions between consciousness and other brain functions...
  81. ncbi Predicting the stream of consciousness from activity in human visual cortex
    John Dylan Haynes
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, United Kingdom
    Curr Biol 15:1301-7. 2005
    ..whether activity in early visual cortex can also predict the rapidly and spontaneously changing stream of consciousness. Here, we used binocular rivalry to induce frequent spontaneous and stochastic changes in conscious experience ..
  82. pmc NMDA receptor hypofunction leads to generalized and persistent aberrant gamma oscillations independent of hyperlocomotion and the state of consciousness
    Tahir Hakami
    Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia
    PLoS ONE 4:e6755. 2009
    ..This also implied to explore the contribution of intracortical and subcortical networks in the generation of these pathophysiological ECoG gamma oscillations...
  83. doi Goals, attention, and (un)consciousness
    Ap Dijksterhuis
    Behavioral Science Institute, Radboud University Nijmegen, 6500 HE Nijmegen, The Netherlands
    Annu Rev Psychol 61:467-90. 2010
    ..cognitive psychology, and social cognition is integrated to discuss the relation between goals, attention, and consciousness. Goals are the tools with which people engage in volitional behavior...
  84. ncbi Episodic autobiographical memory in depression: Specificity, autonoetic consciousness, and self-perspective
    Cédric Lemogne
    CNRS UMR 7593, Pitie Salpetriere Hospital, Paris, France
    Conscious Cogn 15:258-68. 2006
    ..Autonoetic consciousness and self-perspective, which are critical to episodic AM, have never been addressed in depression...
  85. pmc Does mind wandering reflect executive function or executive failure? Comment on Smallwood and Schooler (2006) and Watkins (2008)
    Jennifer C McVay
    Department of Psychology, University of North Carolina, nsboro, NC 27402 6170, USA
    Psychol Bull 136:188-97; discussion 198-207. 2010
    ..We present empirical support for this view from experimental, neuroimaging, and individual-differences research...
  86. doi Electrophysiological evidence for early non-conscious processing of fearful facial expressions
    Alan J Pegna
    Laboratory of Experimental Neuropsychology, Neuropsychology Unit, University of Geneva, Geneva, Switzerland
    Int J Psychophysiol 70:127-36. 2008
    ....
  87. pmc Human posterior auditory cortex gates novel sounds to consciousness
    Iiro P Jaaskelainen
    Massachusetts General Hospital, Massachusetts Institute of Technology, Harvard Medical School, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 101:6809-14. 2004
    ..Our converging findings suggest that transient adaptation of feature-specific neurons within human posterior auditory cortex filters superfluous sounds from entering one's awareness...
  88. ncbi Out-of-body experience, heautoscopy, and autoscopic hallucination of neurological origin Implications for neurocognitive mechanisms of corporeal awareness and self-consciousness
    Olaf Blanke
    Laboratory of Cognitive Neuroscience, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne Swiss Federal Institute of Technology EPFL, 1015 Lausanne, Switzerland
    Brain Res Brain Res Rev 50:184-99. 2005
    ..we believe that the scientific demystification of AP may be useful for the investigation of the cognitive functions and brain regions that mediate processing of the corporeal awareness and self consciousness under normal conditions.
  89. ncbi Volatile anesthetics disrupt frontal-posterior recurrent information transfer at gamma frequencies in rat
    Olga A Imas
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Neurosci Lett 387:145-50. 2005
    ..interactions has been proposed, and gamma (20-60 Hz) oscillations have also been assigned an essential role in consciousness. Here we investigated whether general anesthetics may interfere with the exchange of information encoded in ..
  90. pmc Deactivation of the default mode network as a marker of impaired consciousness: an fMRI study
    Julia Sophia Crone
    Neuroscience Institute and Centre for Neurocognitive Research, Christian Doppler Clinic, Paracelsus Private Medical University, Salzburg, Austria
    PLoS ONE 6:e26373. 2011
    Diagnosis of patients with a disorder of consciousness is very challenging...
  91. doi Brain functional integration decreases during propofol-induced loss of consciousness
    Jessica Schrouff
    Cyclotron Research Centre, University of Liege, Liege, Belgium
    Neuroimage 57:198-205. 2011
    b>Consciousness has been related to the amount of integrated information that the brain is able to generate...
  92. pmc Probing consciousness with event-related potentials in the vegetative state
    F Faugeras
    AP HP, Groupe Hospitalier Pitie Salpetriere, Department of Neurophysiology, Paris, France
    Neurology 77:264-8. 2011
    Probing consciousness in noncommunicating patients is a major medical and neuroscientific challenge...
  93. pmc Electroencephalogram signatures of loss and recovery of consciousness from propofol
    Patrick L Purdon
    Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 110:E1142-51. 2013
    ..To develop EEG signatures that track loss and recovery of consciousness under GA, we recorded high-density EEGs in humans during gradual induction of and emergence from ..
  94. doi Consciousness supporting networks
    Athena Demertzi
    Coma Science Group, Cyclotron Research Center and CHU Neurology Department, Allée du 6 août n 8, Sart Tilman B30, University of Liege, 4000 Liege, Belgium
    Curr Opin Neurobiol 23:239-44. 2013
    Functional neuroimaging shows that patients with disorders of consciousness exhibit disrupted system-level functional connectivity...
  95. doi Integrated information theory of consciousness: an updated account
    G Tononi
    Department of Psychiatry, University of Wisconsin, Mdison, WI 53719, USA
    Arch Ital Biol 150:56-90. 2012
    This article presents an updated account of integrated information theory of consciousness (IIT) and some of its implications. IIT stems from thought experiments that lead to phenomenological axioms and ontological postulates...
  96. doi The role of primordial emotions in the evolutionary origin of consciousness
    D A Denton
    Office of the Dean, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria 3010, Australia
    Conscious Cogn 18:500-14. 2009
    ..They may dominate the stream of consciousness, and can have plenipotentiary power over behaviour...
  97. ncbi Information measures for conscious experience
    G Tononi
    Dipartimento di Fisiologia e Biochimica, , Via S. Zeno 31, 56127 Pisa, Italy
    Arch Ital Biol 139:367-71. 2001
    This paper argues that consciousness is integrated information, and introduces measures to assess it...
  98. doi Detecting consciousness: a unique role for neuroimaging
    Adrian M Owen
    The Brain and Mind Institute, Department of Psychology, The University of Western Ontario, London, Ontario N6A 5B7, Canada
    Annu Rev Psychol 64:109-33. 2013
    ..another person is conscious and aware? Putting aside deeper philosophical considerations about the nature of consciousness itself, historically, the only reliable method for detecting awareness in others has been through a predicted ..
  99. ncbi Consciousness and arousal effects on emotional face processing as revealed by brain oscillations. A gamma band analysis
    Michela Balconi
    Laboratory of Cognitive Psychology, Department of Psychology, Catholic University of Milan, Largo Gemelli, 1 20123 Milan, Italy
    Int J Psychophysiol 67:41-6. 2008
    ..The results showed that both consciousness and significance of the stimulus in terms of arousal can modulate the power synchronization (ERD decrease) ..
  100. ncbi Anxiety and self-consciousness in patients with minor facial lacerations
    Nicola J Tebble
    Wound Healing Research Unit, University of Wales College of Medicine, Cardiff, UK
    J Adv Nurs 47:417-26. 2004
    ....
  101. pmc Stable and dynamic cortical electrophysiology of induction and emergence with propofol anesthesia
    Jonathan D Breshears
    Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:21170-5. 2010
    The mechanism(s) by which anesthetics reversibly suppress consciousness are incompletely understood...

Research Grants71

  1. Combination drug treatment to inhibit multiple cell death pathways after TBI
    ALAN IRA FADEN; Fiscal Year: 2010
    ..CDC) defines traumatic brain injury (TBI) as craniocerebral trauma associated with a decreased level of consciousness, amnesia, other neurologic or neuropsychological abnormalities, skull fracture, intracranial lesions, or death...
  2. Mechanisms of Vasovagal Syncope
    Julian M Stewart; Fiscal Year: 2013
    ..provided by applicant): Vasovagal syncope (VVS, simple faint) is the most common cause of transient loss of consciousness and is the acute episodic form of orthostatic intolerance (OI)...
  3. Connexins in Neuronal and Glial Gap Junctions in the Central Nervous System
    John E Rash; Fiscal Year: 2012
    ..and optimizing the high-frequency neuronal oscillatory synchronizations that are thought to underlie consciousness, arousal from sleep, cognition, associative binding for learning and memory, and fine motor control, and which ..
  4. EFFECT OF DRUGS OF ABUSE ON NEURONAL REDOX AND METHYLATION STATUS
    Richard C Deth; Fiscal Year: 2012
    ..in their chemical and pharmacological profiles, but they act on neural systems which support attention and consciousness, and their repetitive use leads to a state of dependence, characterized by withdrawal syndromes...
  5. RNA-Seq studies of Gene Expression in Cells and Networks in FI and ACC in Autism
    Barbara J Wold; Fiscal Year: 2010
    ..homeostatic systems, including those in the hypothalamus, the FI/ACC system appears to have direct access to consciousness and motivation...
  6. Orexin Receptor Agonists for the Treatment of Excessive Daytime Sleepiness and Ca
    PAUL STUART HUMPHRIES; Fiscal Year: 2013
    ..from anesthesia paradigm in order to efficiently measure the ability of lead compounds to positively affect consciousness. The proof of concept in vivo mouse model of narcolepsy utilizes proprietary sleep EEG software that is ..
  7. Development of a repetitive concussion traumatic brain injury model
    Michael J Whalen; Fiscal Year: 2013
    ..and in which robust and long lasting cognitive deficits are induced in the absence of seizures, loss of consciousness, and gross structural brain lesions...
  8. Volatile Anesthetic Regulation of TASK Tandem Pore Potassium Channels
    Joseph F Cotten; Fiscal Year: 2012
    ..TASK-3 function is also inhibited by GqPCR activation. GqPCRs in the CNS regulate memory, wakefulness, and consciousness and peripherally are important regulators of smooth muscle tone...
  9. Neurobiological studies of gammahydroxybutyrate
    Thomas S Kilduff; Fiscal Year: 2012
    ..metabolism, has profound effects on the activity of the central nervous system (CNS), particularly on consciousness. Because of its soporific effects, GHB has become both a drug of abuse and, paradoxically, a clinically useful ..
  10. TBI &Alcohol Abuse: Co-occurring Conditions that Enhance Brain Damage
    Donald M Kuhn; Fiscal Year: 2012
    ..g., brief change in mental status or consciousness) to severe (e.g., extended unconsciousness, prolonged amnesia, altered cognitive function)...
  11. Chemokines in Zambian children with Cerebral Malaria
    Monique F Stins; Fiscal Year: 2013
    ..Neurological symptoms and signs include impaired consciousness, coma, delirium, seizures, and increased intracranial hypertension...
  12. Autonomic Rare Diseases Clinical Research Consortium
    DAVID HERLIE ROBERTSON; Fiscal Year: 2013
    ..Affected patients frequently have palpitations or lose consciousness, and some have a rapidly fatal course...
  13. Remote effects of focal hippocampal seizures on neocortical function
    Hal Blumenfeld; Fiscal Year: 2013
    ..Interestingly, partial temporal lobe seizures often cause functional deficits such as impaired consciousness, which is not expected from local hippocampal impairment alone...
  14. Arousal, orexins and anesthesia
    MAX KELZ; Fiscal Year: 2010
    ..perioperative patient care through a better understanding of the mechanisms by which anesthetics suppress consciousness. This proposal will enhance his training toward that end by providing formal education in sleep neurobiology (..
  15. Towards the neuronal correlates of visual awareness
    Gabriel Kreiman; Fiscal Year: 2009
    ..system composed of neurons and synapses, can give rise to what seems to be the least physical property of all: consciousness. How this transformation takes place has preoccupied generations of clinicians and scientists...
  16. The GE PETtrace Cyclotron: A Scientific Resource for the State of Arizona
    Eric M Reiman; Fiscal Year: 2010
    ..It made major contributions to the study of memory, consciousness, emotion, temperature and pain sensation, hunger, satiation, taste and the predisposition to obesity, the role ..
  17. Serotonin neurons in arousal, epilepsy and SUDEP.
    GORDON FRANK BUCHANAN; Fiscal Year: 2013
    ..at the Yale School of Medicine relevant to the regulation of sleep and wakefulness and the regulation of consciousness following seizures...
  18. Rational polytherapy in the treatment of cholinergic seizures
    Claude G Wasterlain; Fiscal Year: 2013
    ..Our preliminary results suggest that such three-drug combinations can, with little depression of consciousness, stop seizures induced by high-dose lithium and pilocarpine and refractory to a profoundly anesthetic dose of ..
  19. CELL IDENTITY DETERMINATION IN CEREBRAL CORTEX
    Christopher A Walsh; Fiscal Year: 2013
    ..development of the cerebral cortex (the portion of the brain that controls higher functions such as memory and consciousness) is essential for normal cognitive function, and requires the precise completion of a series of developmental ..
  20. Subcortical control of neocortical slowing during focal hippocampal seizures
    JOSHUA ETHAN MOTELOW; Fiscal Year: 2012
    ..In addition to amnesia, patients typically exhibit impaired consciousness. In humans, focal temporal lobe seizures associated with impaired consciousness are positively correlated with ..
  21. Predictors of Speech Quality after Tongue Cancer Surgery
    Maureen Stone; Fiscal Year: 2013
    ..Patients with poor speech avoid social situations, develop self-consciousness, and even depression...
  22. Selective targeting of sodium channel blockers to pain-sensing neurons
    Bruce P Bean; Fiscal Year: 2012
    ..The most effective form of pain relief without loss of consciousness is provided by administration of local anesthetics, which act by inhibiting voltage-dependent sodium channels ..
  23. A Tailored Internet Intervention for Skin Cancer Risk Reduction in Young Adults
    Carolyn J Heckman; Fiscal Year: 2013
    ..skin type, family history of skin cancer, education, socioeconomic status, and geographic locale), appearance consciousness, and past exposure and protective behaviors moderate intervention effects. Aim 3...
  24. Integration of ascending and descending input to auditory cortex
    Matthew I Banks; Fiscal Year: 2013
    ..Understanding cortical mechanisms of anesthetic-induced loss of consciousness will benefit research into the design of hypnotic drugs that have fewer undesirable effects on hemodynamics ..
  25. A Systems Neuroscience Approach for the Study of General Anesthesia
    Emery N Brown; Fiscal Year: 2011
    ..anesthesia is a drug-induced, reversible condition comprised of five behavioral states: hypnosis (loss of consciousness), amnesia (loss of memory), analgesia (loss of pain sensation), akinesia (immobility), and hemodynamic ..
  26. A Study of the Factors Influencing Women's Decision about Childbirth
    MARY J REGAN; Fiscal Year: 2010
    ..first is a projective method commonly used in the social sciences to access knowledge that exists outside of consciousness. The second is a focus group method that provides a venue for birthing women to articulate the conscious basis ..
  27. Consequences of Cardiac Arrest: Brain Injury
    NITISH VYOMESH THAKOR; Fiscal Year: 2013
    ..of hypothermia following CA and a better understanding of the role of the thalamus in chronic disorders of consciousness after CA...
  28. A Neural Systems Approach to Monitoring and Drug-Delivery for General Anesthesia
    PATRICK PURDON; Fiscal Year: 2009
    ..General anesthesia is a drug-induced, reversible condition comprised of five behavioral states: loss of consciousness, amnesia, analgesia, lack of movement, and hemodynamic stability...
  29. Frontoparietal Mechanisms of Anesthetic-induced Unconsciousness
    GEORGE ALEXANDER MASHOUR; Fiscal Year: 2013
    ..of measurable neurophysiologic features of general anesthesia that are informed by the neurobiology of consciousness and that can be explained by neurochemical mechanisms...
  30. Anesthetic actions on GABA(A) fast, slow, tonic and GABA(B) receptors
    M Bruce MacIver; Fiscal Year: 2013
    ..Good evidence points to considerable involvement, for several end-points, including loss of recall, loss of consciousness and even immobility, but other experiments have suggested little or no involvement...
  31. Improving Syncope Risk Stratification in Older Adults
    Benjamin C Sun; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): There are 740,000 annual events of syncope (transient loss of consciousness) that lead to an emergency department (ED) visit, resulting in 250,000 admissions and $2.4 billion in yearly hospital costs...
  32. Neurophysiological Basis of General Anesthesia
    ALEXANDER PROEKT; Fiscal Year: 2013
    ..Understanding how these molecular-level actions lead to reversible loss of consciousness requires a systems neuroscience analysis - defining the actions of anesthetics within the context of highly ..
  33. Mouthpiece for mTBI Detection during Adolescent Contact and Collision Sports
    PAUL L GIBSON; Fiscal Year: 2012
    ..There are approximately 300,000 sports related traumatic brain injuries every year resulting in loss of consciousness. Studies have shown that only about 8-19 percent of sports related traumatic brain injuries result in loss of ..
  34. Minority Stress, Alcohol Use, and Intimate Partner Violence Among Lesbians
    Robin J Lewis; Fiscal Year: 2012
    ..social isolation, rumination, suppression), Stigma-Related Processes (i.e., internalized homophobia, stigma consciousness, concealment), Psychological and Relationship Distress (i.e...
  35. Propofol in Exhaled Breath: Real-time Detection by Surface Acoustic Wave Sensors
    DONN MICHAEL DENNIS; Fiscal Year: 2012
    ..g., desflurane, nitrous oxide) to maintain the appropriate "level of consciousness"/depth of anesthesia...
  36. Role of the midline thalamus in arousal, attention and cognition
    ROBERT PAUL VERTES; Fiscal Year: 2013
    ..should provide critical information on the modulatory effects of RE on the limbic forebrain in the control of arousal/attention, affect and cognition with direct implications for disorders of consciousness, schizophrenia and epilepsy.
  37. Mild Hypothermia for Resuscitated Out-of-Hospital Cardiac Arrest Patients
    Francis Kim; Fiscal Year: 2012
    ..Brain damage is a major cause of morbidity and mortality in these patients with most never regaining consciousness. Safe and effective therapies that improve outcome after cardiac arrest are urgently needed...
  38. A Comparative History of Twentieth-Century Catholic Hospitals
    Barbra Mann Wall; Fiscal Year: 2010
    ..challenges Catholic hospitals encountered as marketplace values, modernization processes, shifts in religious consciousness, healthcare reform efforts, and federal regulation accelerated...
  39. Scalable Software for Reverse Engineering Neural Circuits from Histology
    CHRISTOPHER CHARLES LAW; Fiscal Year: 2013
    ..circuit within each brain is called its connectome, and understanding how it works and enables cognition, consciousness, or intelligence is one of the most fundamental questions in science...
  40. Clot Lysis: Evaluating Accelerated Resolution of IVH Phase III (CLEAR III)
    Daniel F Hanley; Fiscal Year: 2013
    ..signal that we can translate IVH animal models to human treatment with robust beneficial effects on level of consciousness, ICU treatment intensity, survival, and lowered neurologic morbidity burden as measured by functional ..
  41. Affordable Adolescent Athletic Mild Traumatic Brain Injury Risk Management System
    DANIEL S HEDIN; Fiscal Year: 2011
    ..Approximately 300,000 of these injuries result in a loss of consciousness. Adolescents aged 15 to 19 years are more likely to sustain a traumatic brain injury than other age groups in ..
  42. Novel Interneurons Mediating Feedforward Inhibition
    Ariel Agmon; Fiscal Year: 2013
    ..rise to cortical activity is therefore essential for understanding both normal and pathological states of consciousness, such as schizophrenia or autism, when internal representations appear to go awry...
  43. Neuroimaging of Anesthetic Modulation of Human Consciousness
    Shi Jiang Li; Fiscal Year: 2013
    ..of this project is to understand the systems-level neural mechanisms by which general anesthetics suppress consciousness and allow its return during emergence in the human brain...
  44. Molecular mechanisms of Shiga toxin action in the mammal central nervous system
    Fumiko Obata; Fiscal Year: 2011
    ..a broad spectrum of symptoms as cortical blindness, poor fine-motor coordination, seizures and changes in consciousness including coma. Importantly, CNS manifestations often associate with mortality or severe sequelae...
  45. MRI Structural and Functional Connectivity Changes in Temporal Lobe Epilepsy
    Victoria L Morgan; Fiscal Year: 2013
    ..TLE) causes seizures with widespread effects across the brain that result in complex events including loss of consciousness and motor phenomena...
  46. Immunologic Effects and a Structural "Countermarketing" Intervention: Racism, the
    NAA OYO KWATE; Fiscal Year: 2009
    ..deliver stark facts about American inequality in predominantly African American neighborhoods, thereby raising consciousness and minimizing negative health outcomes...
  47. CRCNS: Spatiotemporal imaging study of the mechanisms of binocular rivalry
    Bin He; Fiscal Year: 2013
    ..binocular rivalry has become the main model system for studying neural mechanisms of visual awareness and consciousness. Given the rapid development in neuroimaging techniques in recent years and the critical questions that remain ..
  48. Thrombolysis in Pediatric Stroke Study (TIPS)
    Catherine M Amlie-Lefond; Fiscal Year: 2013
    ..4 or more points on the Pediatric adaptation of the NIH Stroke Scale (PedNIHSS) or deterioration in level of consciousness. The two secondary aims are: (1) To measure the pharmacokinetics of tPA, including free tPA, PAI-1, and tPA ..
  49. Detection and Control of Epilepsy
    Dominique M Durand; Fiscal Year: 2013
    ..experience recurrent seizures that can cause a variety of symptoms ranging from muscle stiffness to loss of consciousness. Partial epilepsy is the most common syndrome in adult epilepsy patients and mesial temporal lobe epilepsy (..
  50. MAPPING ELOQUENT CORTEX USING RESTING STATE CORTICAL PHYSIOLOGY
    Joshua S Shimony; Fiscal Year: 2012
    ..this project is significant because resting-state mapping will obviate the need for patient participation/consciousness to successfully identify critical functional sites in the context of a brain tumor...
  51. Evaluating an emergency department observation syncope protocol for older adults
    Benjamin C Sun; Fiscal Year: 2010
    ..Syncope, defined as a transient loss of consciousness, accounts for over 700,000 annual U.S...
  52. Improving the language and literacy skills of Spanish-English Bilingual Kindergar
    MARIELA PAEZ; Fiscal Year: 2011
    ..and varied language experiences;teaching individual words;teaching word-learning strategies;and fostering word consciousness. There is strong evidence that these four components are effective strategies for improving vocabulary ..
  53. Field Deployable, Automatic, EEG Seizure Detector and Brain Dysfunction Monitor
    STEPHANE BIBIAN; Fiscal Year: 2010
    ..highly relevant technologies, including a commercial-grade portable, low cost, and robust intra-operative consciousness monitor that tracks patient's cortical activity in real-time during surgical procedures requiring ..
  54. Long Term Outcomes in ICU Patients: Delirium & Apolipoprotein E
    Sheila Alexander; Fiscal Year: 2009
    Delirium and Apolipoprotein Delirium, a disturbance is consciousness with inattention accompanied by a change in cognition or perceptual disturbances, is a common occurrence in hospitalized patients in and out of the ICU...
  55. Sleep Neurobiology and Circuitry
    Priyattam J Shiromani; Fiscal Year: 2013
    ..How the brain switches between states of consciousness is not known, but researchers have now determined that a distributed network of neurons are responsible for ..
  56. Critical Consciousness-Based HIV Prevention for Black Gay/Bi/MSM Male Adolescents
    Gary W Harper; Fiscal Year: 2013
    ..This study seeks to develop and test a culturally and developmentally appropriate critical consciousness-based HIV prevention intervention for BA-MSM...
  57. General anesthetics and cerebral cortical sensory integration
    ANTHONY GEORGE HUDETZ; Fiscal Year: 2013
    ..The overall goal of this project is to understand the mechanisms by which general anesthetics remove consciousness and allow its return during emergence...
  58. Central Cholinergic System, Its History &Current Status
    ALEXANDER KARCZMAR; Fiscal Year: 2002
    ..and endocrine activities; and cholinergically linked behaviors such as addiction, aggression, cognition and consciousness or self-awareness...
  59. Neural correlates of impaired consciousness in childhood absence epilepsy
    Jennifer Guo; Fiscal Year: 2013
    ..Childhood absence epilepsy (CAE) is a generalized form of epilepsy causing transitory impairments of consciousness. However, this impairment during seizures is not an all-or-nothing phenomenon but variably affects task ..
  60. GENERAL ANESTHETICS AND CLONED VOLTAGE-GATED CHANNELS
    ANA CORREA; Fiscal Year: 2000
    General anesthesia is a condition in which loss of memory and consciousness is accompanied by loss of pain sensation...
  61. Developing MBSR for Application in Alcoholism Treatment
    Gerard J Connors; Fiscal Year: 2010
    ..MBSR, with its emphasis on the development of detached observation and awareness of the contents of consciousness, has been shown to be efficacious in increasing the ability to cope with stress and in enhancing coping and ..
  62. The Effect of Emotion Word Priming on the Perception of Emotion
    JENNIFER MARIE BINZAK FUGATE; Fiscal Year: 2010
    ..intriguingly, words might influence emotion perception by affecting the selection of information presented for consciousness (binocular rivalry task)...
  63. Cell adhesion molecules in cerebral malaria.
    Henri van der Heyde; Fiscal Year: 2005
    ..Results from clinical studies of P. falciparum patients indicate that these individuals develop impaired consciousness with posturing (cerebral malaria), respiratory distress with lactic acidosis, anemia and (rarely) acute ..
  64. CHILD AND FAMILY FUNCTIONING AFTER PEDIATRIC HEAD TRAUMA
    JoAnne Youngblut; Fiscal Year: 2001
    ..hospitalized child with an injury where a blow to the head was likely and either a history of loss of consciousness, symptoms of head injury in children, x-ray or CT scan suggestive of TBI will be recruited...
  65. Utah Center for Exploring Mind-Body Interactions (UCEMB*
    Yoshio Nakamura; Fiscal Year: 2006
    ..Third, UCEMBI will establish a vibrant intersection of pain research, consciousness studies, and investigations of mind-body interactions that will open new visions for mind-body research...
  66. Laser Cather for Ablation of Ventricular Tachycardia
    Ashok Gowda; Fiscal Year: 2002
    ..lack sufficient time to fill with blood prior to each contraction often resulting in dizziness, loss of consciousness and sudden cardiac arrest...
  67. NEUROPSYCHOPHARMACOLOGY OF ALTERED CONSCIOUSNESS
    Reese Jones; Fiscal Year: 2007
    ..The studies are multidisciplinary. They involve only human volunteers. The research will further understanding psychoactive drug use, health consequences and management. ..
  68. Facial Expression During Pain
    MAMOONA ARIF; Fiscal Year: 2009
    ..care, many factors alter verbal communication with patients including tracheal incubation, reduced level of consciousness, sedation, and administration of paralyzing drugs...
  69. Pediatric Mild Head Injury: Definition and Consequences
    Ronald Maio; Fiscal Year: 2004
    ..by blunt trauma or acceleration deceleration injury to the head followed by any combination of brief loss of consciousness(<30 min...
  70. BRAIN AND SPINAL CORD CONTRIBUTIONS TO ANESTHETIC ACTION
    JOSEPH ANTOGNINI; Fiscal Year: 2005
    ..Because the MRF and thalamus are critical to consciousness and memory, it is likely that disruption of nociceptive input to these sites decreases the likelihood of ..
  71. LASER CATHETER FOR ABLATION OF VENTRICULAR TACHYCARDIA
    Ashok Gowda; Fiscal Year: 1999
    ..do not fill with sufficient amounts of blood prior to each contraction, often resulting in dizziness, loss of consciousness or sudden cardiac arrest...