wakefulness

Summary

Summary: A state in which there is an enhanced potential for sensitivity and an efficient responsiveness to external stimuli.

Top Publications

  1. ncbi The memory function of sleep
    Susanne Diekelmann
    University of Lubeck, Department of Neuroendocrinology, 23538 Lubeck, Germany
    Nat Rev Neurosci 11:114-26. 2010
  2. ncbi A new method for measuring daytime sleepiness: the Epworth sleepiness scale
    M W Johns
    Sleep Disorders Unit, Epworth Hospital, Melbourne, Victoria, Australia
    Sleep 14:540-5. 1991
  3. ncbi Hypothalamic regulation of sleep and circadian rhythms
    Clifford B Saper
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, USA
    Nature 437:1257-63. 2005
  4. ncbi Breakdown of cortical effective connectivity during sleep
    Marcello Massimini
    Department of Psychiatry, University of Wisconsin, Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA
    Science 309:2228-32. 2005
  5. pmc Control of sleep and wakefulness
    Ritchie E Brown
    Laboratory of Neuroscience, VA Boston Healthcare System and Harvard Medical School, Brockton, Massachusetts 02301, USA
    Physiol Rev 92:1087-187. 2012
  6. pmc Sleep state switching
    Clifford B Saper
    Department of Neurology, Program in Neuroscience, and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Neuron 68:1023-42. 2010
  7. ncbi Local sleep and learning
    Reto Huber
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin 53719, USA
    Nature 430:78-81. 2004
  8. pmc Imaging large-scale neural activity with cellular resolution in awake, mobile mice
    Daniel A Dombeck
    Department of Molecular Biology, Carl Icahn Labs, Princeton University, Princeton, NJ 08544, USA
    Neuron 56:43-57. 2007
  9. ncbi The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness
    Takeshi Sakurai
    Department of Pharmacology, Institute of Basic Medical Science, University of Tsukuba, Ibaraki 305 8575, Japan
    Nat Rev Neurosci 8:171-81. 2007
  10. ncbi Correlates of sleep and waking in Drosophila melanogaster
    P J Shaw
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Science 287:1834-7. 2000

Detail Information

Publications314 found, 100 shown here

  1. ncbi The memory function of sleep
    Susanne Diekelmann
    University of Lubeck, Department of Neuroendocrinology, 23538 Lubeck, Germany
    Nat Rev Neurosci 11:114-26. 2010
    ....
  2. ncbi A new method for measuring daytime sleepiness: the Epworth sleepiness scale
    M W Johns
    Sleep Disorders Unit, Epworth Hospital, Melbourne, Victoria, Australia
    Sleep 14:540-5. 1991
    ..ESS scores of patients who simply snored did not differ from controls...
  3. ncbi Hypothalamic regulation of sleep and circadian rhythms
    Clifford B Saper
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, USA
    Nature 437:1257-63. 2005
    ..has begun to identify the brain circuitry and neurotransmitters that regulate our daily cycles of sleep and wakefulness. The latter depends on a network of cell groups that activate the thalamus and the cerebral cortex...
  4. ncbi Breakdown of cortical effective connectivity during sleep
    Marcello Massimini
    Department of Psychiatry, University of Wisconsin, Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA
    Science 309:2228-32. 2005
    ..During quiet wakefulness, an initial response (approximately 15 milliseconds) at the stimulation site was followed by a sequence of ..
  5. pmc Control of sleep and wakefulness
    Ritchie E Brown
    Laboratory of Neuroscience, VA Boston Healthcare System and Harvard Medical School, Brockton, Massachusetts 02301, USA
    Physiol Rev 92:1087-187. 2012
    This review summarizes the brain mechanisms controlling sleep and wakefulness. Wakefulness promoting systems cause low-voltage, fast activity in the electroencephalogram (EEG)...
  6. pmc Sleep state switching
    Clifford B Saper
    Department of Neurology, Program in Neuroscience, and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Neuron 68:1023-42. 2010
    We take for granted the ability to fall asleep or to snap out of sleep into wakefulness, but these changes in behavioral state require specific switching mechanisms in the brain that allow well-defined state transitions...
  7. ncbi Local sleep and learning
    Reto Huber
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin 53719, USA
    Nature 430:78-81. 2004
    ..The amount of SWA is homeostatically regulated, increasing after wakefulness and returning to baseline during sleep...
  8. pmc Imaging large-scale neural activity with cellular resolution in awake, mobile mice
    Daniel A Dombeck
    Department of Molecular Biology, Carl Icahn Labs, Princeton University, Princeton, NJ 08544, USA
    Neuron 56:43-57. 2007
    ..Behaviorally correlated calcium transients from large neuronal and astrocytic populations were routinely measured, with an estimated motion-induced false positive error rate of <5%...
  9. ncbi The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness
    Takeshi Sakurai
    Department of Pharmacology, Institute of Basic Medical Science, University of Tsukuba, Ibaraki 305 8575, Japan
    Nat Rev Neurosci 8:171-81. 2007
    Sleep and wakefulness are regulated to occur at appropriate times that are in accordance with our internal and external environments...
  10. ncbi Correlates of sleep and waking in Drosophila melanogaster
    P J Shaw
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Science 287:1834-7. 2000
    ..These results implicate the catabolism of monoamines in the regulation of sleep and waking in the fly and suggest that Drosophila may serve as a model system for the genetic dissection of sleep...
  11. ncbi Neural substrates of awakening probed with optogenetic control of hypocretin neurons
    Antoine R Adamantidis
    Department of Psychiatry and Behavioral Sciences, Stanford University, 701B Welch Road, Palo Alto, California 94304, USA
    Nature 450:420-4. 2007
    ..that direct, selective, optogenetic photostimulation of Hcrt neurons increased the probability of transition to wakefulness from either slow wave sleep or rapid eye movement sleep...
  12. ncbi Practice with sleep makes perfect: sleep-dependent motor skill learning
    Matthew P Walker
    Laboratory of Neurophysiology, Department of Psychiatry, Harvard Medical School, 74 Fenwood Road, Boston, Massachusetts 02115, USA
    Neuron 35:205-11. 2002
    ..This finding of sleep-dependent motor skill improvement may have important implications for the efficient learning of all skilled actions in humans...
  13. ncbi Practice parameters for clinical use of the multiple sleep latency test and the maintenance of wakefulness test
    Michael R Littner
    VA Greater Los Angeles Healthcare System, CA, USA
    Sleep 28:113-21. 2005
    ..sleep clinician on appropriate clinical use of the Multiple Sleep Latency Test (MSLT), and the Maintenance of Wakefulness Test (MWT)...
  14. pmc Dynamic sensory representations in the olfactory bulb: modulation by wakefulness and experience
    Hiroyuki K Kato
    Center for Neural Circuits and Behavior and Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 76:962-75. 2012
    ..the brain influenced by the state of an animal? Here we use chronic two-photon calcium imaging to explore how wakefulness and experience shape odor representations in the mouse olfactory bulb...
  15. ncbi Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep
    Vladyslav V Vyazovskiy
    Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Blvd, Madison, Wisconsin 53719, USA
    Nat Neurosci 11:200-8. 2008
    Plastic changes occurring during wakefulness aid in the acquisition and consolidation of memories. For some memories, further consolidation requires sleep, but whether plastic processes during wakefulness and sleep differ is unclear...
  16. ncbi Development of the brain's default mode network from wakefulness to slow wave sleep
    Philipp G Sämann
    Max Planck Institute of Psychiatry, Neuroimaging Research Group, 80804 Munich, Germany
    Cereb Cortex 21:2082-93. 2011
    ..network (DMN) and its anticorrelated network (ACN) that are involved in internal and external awareness during wakefulness. Using independent component analysis, cross-correlation analysis (CCA), and intraindividual dynamic network ..
  17. ncbi Odor cues during slow-wave sleep prompt declarative memory consolidation
    Björn Rasch
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160 23a, 23538 Lubeck, Germany
    Science 315:1426-9. 2007
    ..Odor re-exposure was ineffective during rapid eye movement sleep or wakefulness or when the odor had been omitted during prior learning...
  18. ncbi Cortisol awakening response and psychosocial factors: a systematic review and meta-analysis
    Yoichi Chida
    Psychobiology Group, Department of Epidemiology and Public Health, University College London, United Kingdom
    Biol Psychol 80:265-78. 2009
    ..This review concludes that different psychosocial factors are associated with an enhanced or reduced cortisol awakening response...
  19. pmc Direct evidence for wake-related increases and sleep-related decreases in synaptic strength in rodent cortex
    Zhong Wu Liu
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 30:8671-5. 2010
    ..Since stronger synapses require more energy, space, and supplies, a generalized renormalization of synapses may be an important function of sleep...
  20. ncbi The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation
    Hans P A Van Dongen
    Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, Department of Psychiatry, and Centerfor Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    Sleep 26:117-26. 2003
    ....
  21. ncbi Dissociable stages of human memory consolidation and reconsolidation
    Matthew P Walker
    Laboratory of Neurophysiology, Massachusetts Mental Health Center, Department of Psychiatry, Harvard Medical School, 74 Fenwood Road, Boston, Massachusetts 02115, USA
    Nature 425:616-20. 2003
    ....
  22. ncbi Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle
    Maan Gee Lee
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, H3A 2B4, Canada
    J Neurosci 25:6716-20. 2005
    Although maintained by multiple arousal systems, wakefulness falters if orexin (hypocretin), orexin receptors, or orexin neurons are deficient; narcolepsy results with hypersomnolence or sudden onset of rapid eye movement sleep [or ..
  23. pmc Acute optogenetic silencing of orexin/hypocretin neurons induces slow-wave sleep in mice
    Tomomi Tsunematsu
    Division of Cell Signaling, National Institute for Physiological Sciences, Okazaki 444 8787, Japan
    J Neurosci 31:10529-39. 2011
    Orexin/hypocretin neurons have a crucial role in the regulation of sleep and wakefulness. To help determine how these neurons promote wakefulness, we generated transgenic mice in which orexin neurons expressed halorhodopsin (orexin/Halo ..
  24. ncbi Modeling sleep and wakefulness in the thalamocortical system
    Sean Hill
    Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Boulevard, Madison, WI 53719 1176, USA
    J Neurophysiol 93:1671-98. 2005
    When the brain goes from wakefulness to sleep, cortical neurons begin to undergo slow oscillations in their membrane potential that are synchronized by thalamocortical circuits and reflected in EEG slow waves...
  25. ncbi Power density in theta/alpha frequencies of the waking EEG progressively increases during sustained wakefulness
    C Cajochen
    Psychiatric University Clinic, Basel, Switzerland
    Sleep 18:890-4. 1995
    ..power density and self-rated fatigue were assessed in nine healthy women during a 40-hour period of sustained wakefulness under constant behavioral and environmental conditions (constant routine protocol)...
  26. ncbi PER3 polymorphism predicts sleep structure and waking performance
    Antoine U Viola
    Surrey Sleep Research Centre, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, UK
    Curr Biol 17:613-8. 2007
    ..EEG) slow-wave activity in non-rapid eye movement (non-REM) sleep and theta and alpha activity during wakefulness and REM sleep were all increased in PER3(5/5) compared to PER3(4/4) individuals...
  27. ncbi Play it again: reactivation of waking experience and memory
    JOSEPH O'NEILL
    MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK
    Trends Neurosci 33:220-9. 2010
    ..Although the mechanisms remain uncertain, there is a growing consensus that such SWR-directed reactivation of brain-wide memory traces could underlie memory consolidation...
  28. ncbi Sleep function and synaptic homeostasis
    Giulio Tononi
    Department of Psychiatry, University of Wisconsin, 6001 Research Park Blvd, Madison, WI 53719, USA
    Sleep Med Rev 10:49-62. 2006
    ..According to the hypothesis, plastic processes occurring during wakefulness result in a net increase in synaptic strength in many brain circuits...
  29. ncbi The sleep switch: hypothalamic control of sleep and wakefulness
    C B Saper
    Dept of Neurology, Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Trends Neurosci 24:726-31. 2001
    ..The posterior lateral hypothalamus contains orexin/hypocretin neurons that are crucial for maintaining normal wakefulness. A model is proposed in which wake- and sleep-promoting neurons inhibit each other, which results in stable ..
  30. pmc Afferents to the orexin neurons of the rat brain
    Kyoko Yoshida
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Comp Neurol 494:845-61. 2006
    Emotions, stress, hunger, and circadian rhythms all promote wakefulness and behavioral arousal...
  31. pmc Local sleep in awake rats
    Vladyslav V Vyazovskiy
    Department of Psychiatry, University of Wisconsin Madison, Madison, 6001 Research Park Boulevard, Wisconsin 53719, USA
    Nature 472:443-7. 2011
    ..Thus, although both the EEG and behaviour indicate wakefulness, local populations of neurons in the cortex may be falling asleep, with negative consequences for performance.
  32. ncbi Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine
    Zhi Li Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka 565 0874, Japan
    Nat Neurosci 8:858-9. 2005
    Caffeine, a component of tea, coffee and cola, induces wakefulness. It binds to adenosine A1 and A2A receptors as an antagonist, but the receptor subtype mediating caffeine-induced wakefulness remains unclear...
  33. ncbi The cortisol awakening response (CAR): facts and future directions
    Eva Fries
    Technische Universitat Dresden, Faculty of Science, Department of Psychology, Dresden, Germany
    Int J Psychophysiol 72:67-73. 2009
    ..The present paper reviews the current knowledge on the neural regulation of the CAR and factors influencing this phenomenon and considerations are addressed concerning the exact function of the CAR...
  34. pmc Two dopaminergic neurons signal to the dorsal fan-shaped body to promote wakefulness in Drosophila
    Qili Liu
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
    Curr Biol 22:2114-23. 2012
    ..Although dopamine (DA) is thought to play a key role in sleep/wake regulation, the identities of the individual DA neurons and their downstream targets required for this process are unknown...
  35. pmc Altered sleep-wake characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice
    Zhi Li Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    Proc Natl Acad Sci U S A 103:4687-92. 2006
    ..Blockade of the histamine H(3) receptor (H(3)R) is proposed to induce wakefulness by regulating the release of various wake-related transmitters, not only histamine...
  36. pmc Unresponsive wakefulness syndrome: a new name for the vegetative state or apallic syndrome
    Steven Laureys
    Dept of Neurology, Cyclotron Research Centre, University Hospital and University of Liège, Belgium
    BMC Med 8:68. 2010
    ..This syndrome has been coined vegetative state. We here present a new name for this challenging neurological condition: unresponsive wakefulness syndrome (abbreviated UWS).
  37. pmc Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep-wake cycle
    Oum Kaltoum Hassani
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada H3A 2B4
    Proc Natl Acad Sci U S A 106:2418-22. 2009
    ..Orx or hypocretin) in the lateral hypothalamus, a peptide and region known to be critical for maintaining wakefulness. Evidence from knockout and c-Fos studies suggests, however, that the MCH neurons might play a different role ..
  38. pmc Wakefulness affects synaptic and network activity by increasing extracellular astrocyte-derived adenosine
    L Ian Schmitt
    Department of Neuroscience, Tufts University Medical School, Boston, MA 02111, USA
    J Neurosci 32:4417-25. 2012
    ..studies have not determined whether the concentration of this signaling molecule increases in response to wakefulness. Here, we show that the level of adorA1R activation increases in response to wakefulness in mice (Mus musculus)...
  39. pmc Separating the contribution of glucocorticoids and wakefulness to the molecular and electrophysiological correlates of sleep homeostasis
    Valérie Mongrain
    Center for Integrative Genomics, University of Lausanne, CH 1015 Lausanne, Switzerland
    Sleep 33:1147-57. 2010
    ..Because sleep deprivation also induces stress, we here determined the contribution of the corticosterone component of the stress response to the electrophysiological and molecular markers of sleep need in mice...
  40. pmc Differential effects of controllable and uncontrollable footshock stress on sleep in mice
    Larry D Sanford
    Sleep Research Laboratory, Department of Pathology and Anatomy, Eastern Virginia Medical School, P O Box 1980, Norfolk, VA 23501, USA
    Sleep 33:621-30. 2010
    ..We compared sleep in animals trained with IS to that in animals trained with escapable shock (ES), a controllable stressor, in a paradigm in which animals always received shock but could terminate it by their actions...
  41. ncbi Induction of hippocampal long-term potentiation during waking leads to increased extrahippocampal zif-268 expression during ensuing rapid-eye-movement sleep
    Sidarta Ribeiro
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 22:10914-23. 2002
    ....
  42. pmc Widespread changes in synaptic markers as a function of sleep and wakefulness in Drosophila
    Giorgio F Gilestro
    Department of Psychiatry, University of Wisconsin, Madison, WI 53719, USA
    Science 324:109-12. 2009
    ..However, little is known about how wakefulness and sleep affect synapses...
  43. ncbi Fos expression in orexin neurons varies with behavioral state
    I V Estabrooke
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Neurosci 21:1656-62. 2001
    ..Lack of orexin produces narcolepsy, which is characterized by poor maintenance of wakefulness and intrusions of rapid eye movement (REM) sleep or REM sleep-like phenomena into wakefulness...
  44. pmc A video method to study Drosophila sleep
    John E Zimmerman
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, 125 South 31st St, Suite 2100, Philadelphia, PA 19104 3403, USA
    Sleep 31:1587-98. 2008
    ..To use video to determine the accuracy of the infrared beam-splitting method for measuring sleep in Drosophila and to determine the effect of time of day, sex, genotype, and age on sleep measurements...
  45. ncbi Sleep after learning aids memory recall
    Steffen Gais
    Department of Neuroendocrinology, University of Lubeck, 23538 Lubeck, Germany
    Learn Mem 13:259-62. 2006
    ..Sleep deprivation has a detrimental effect on memory, which was significant after a night of recovery sleep. Thus, fatigue accumulating during wake intervals could be ruled out as a confound...
  46. ncbi High sensitivity of human melatonin, alertness, thermoregulation, and heart rate to short wavelength light
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinic, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    J Clin Endocrinol Metab 90:1311-6. 2005
    ....
  47. ncbi Extensive and divergent effects of sleep and wakefulness on brain gene expression
    Chiara Cirelli
    Department of Psychiatry, University of Wisconsin, Madison, 53719, USA
    Neuron 41:35-43. 2004
    ..change their expression between day and night and demonstrate that half of them are modulated by sleep and wakefulness independent of time of day...
  48. ncbi Sleep homeostasis in Drosophila melanogaster
    Reto Huber
    Department of Psychiatry, University of Wisconsin, Madison 53719, USA
    Sleep 27:628-39. 2004
    ..A central feature of mammalian sleep is its homeostatic regulation by the amount of previous wakefulness. Dissecting the mechanisms of homeostatic regulation is likely to provide key insights into the functions of ..
  49. pmc Effects and mechanisms of wakefulness on local cortical networks
    Christine M Constantinople
    Department of Neuroscience and the Kavli Institute for Brain Science, Columbia University, New York, NY 10032, USA
    Neuron 69:1061-8. 2011
    ..impacts cortical circuitry, we recorded intracellularly from the same neurons, under anesthesia and subsequent wakefulness, in rat barrel cortex...
  50. ncbi Adenosine, energy metabolism and sleep homeostasis
    Tarja Porkka-Heiskanen
    Institute of Biomedicine, University of Helsinki, PO Box 63, 00014 University of Helsinki, Helsinki, Finland
    Sleep Med Rev 15:123-35. 2011
    ..appears to be central in the regulation/execution of recovery sleep after sleep deprivation (SD), or prolonged wakefulness. Adenosine concentration increases in this area during SD, and this increase induces sleep while prevention of ..
  51. ncbi Precise olfactory responses tile the sniff cycle
    Roman Shusterman
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, USA
    Nat Neurosci 14:1039-44. 2011
    ..The temporal specificity of mitral/tufted cell output provides a potentially rich source of information for downstream olfactory areas...
  52. ncbi Sleep selectively enhances memory expected to be of future relevance
    Ines Wilhelm
    Department of Neuroendocrinology, University of Lubeck, 23538 Lubeck, Germany
    J Neurosci 31:1563-9. 2011
    ..Human subjects learned declarative memories (word paired associates) before retention periods of sleep or wakefulness. Postlearning sleep compared with wakefulness produced a strong improvement at delayed retrieval only if the ..
  53. ncbi The homeostatic regulation of sleep need is under genetic control
    P Franken
    Biochemistry and Neurophysiology Unit, Department of Psychiatry, University of Geneva, Chene Bourg, Switzerland
    J Neurosci 21:2610-21. 2001
    ..in the 1-4 Hz range, in slow-wave sleep (SWS) is in a quantitative and predictive relationship with prior wakefulness. Thus, sleep loss evokes a proportional increase in delta power, and excess sleep a decrease...
  54. ncbi Sleep enhances plasticity in the developing visual cortex
    M G Frank
    W. M. Keck Foundation Center, for Integrative Neuroscience, Department of Physiology, University of California, San Francisco, San Francisco, CA 94143-0444, USA
    Neuron 30:275-87. 2001
    ..sleep enhanced the effects of a preceding period of monocular deprivation on visual cortical responses, but wakefulness in complete darkness did not do so...
  55. ncbi From waking to sleeping: neuronal and chemical substrates
    Barbara E Jones
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal, Quebec H3A 2B4, Canada
    Trends Pharmacol Sci 26:578-86. 2005
    ..Selective enhancement and attenuation of their discharge, transmitter release and postsynaptic actions comprise the substrates for the major stimulant and hypnotic drugs...
  56. ncbi The official World Association of Sleep Medicine (WASM) standards for recording and scoring periodic leg movements in sleep (PLMS) and wakefulness (PLMW) developed in collaboration with a task force from the International Restless Legs Syndrome Study Grou
    Marco Zucconi
    Sleep Disorders Center, San Raffaele Hospital, Milano, Italy
    Sleep Med 7:175-83. 2006
  57. ncbi The histaminergic system regulates wakefulness and orexin/hypocretin neuron development via histamine receptor H1 in zebrafish
    Maria Sundvik
    Neuroscience Center and Institute of Biomedicine, Anatomy, Faculty of Medicine, P O B 63, 00014 University of Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland
    FASEB J 25:4338-47. 2011
    The histaminergic and hypocretin/orexin (hcrt) neurotransmitter systems play crucial roles in alertness/wakefulness in rodents...
  58. ncbi Are spatial memories strengthened in the human hippocampus during slow wave sleep?
    Philippe Peigneux
    Cyclotron Research Center, University of Liege, B 4000 Liege, Belgium
    Neuron 44:535-45. 2004
    ....
  59. pmc Why we sleep: the temporal organization of recovery
    Emmanuel Mignot
    Howard Hughes Medical Institute and Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, United States of America
    PLoS Biol 6:e106. 2008
  60. pmc Noradrenergic modulation of wakefulness/arousal
    Craig W Berridge
    Psychology Department, University of Wisconsin, Madison, WI 53706, USA
    Sleep Med Rev 16:187-97. 2012
    ....
  61. ncbi Neuropeptide S promotes wakefulness through activation of the posterior hypothalamic histaminergic and orexinergic neurons
    P Zhao
    Department of Neuroscience, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, 199 Donggang Xi Road, Lanzhou 730000, PR China
    Neuroscience 207:218-26. 2012
    ..NPS at 0.1 and 1 nmol increased significantly wakefulness (W) during the first 2 h (54.7 ± 3.2 and 64.9 ± 2.1 min, respectively, vs. 41.4 ± 2...
  62. ncbi Dopaminergic role in stimulant-induced wakefulness
    J P Wisor
    Sleep Disorders Research Center, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 21:1787-94. 2001
    ..mice, deletion of the dopamine transporter (DAT) gene reduced non-rapid eye movement sleep time and increased wakefulness consolidation independently from locomotor effects...
  63. ncbi Sleep preferentially enhances memory for emotional components of scenes
    Jessica D Payne
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Psychol Sci 19:781-8. 2008
    ..Memory for a negative scene develops differentially across time delays containing sleep and wake, with sleep selectively consolidating those aspects of memory that are of greatest value to the organism...
  64. ncbi EEG microstates of wakefulness and NREM sleep
    Verena Brodbeck
    Brain Imaging Center, Department of Neurology, University of Frankfurt, A M, Germany
    Neuroimage 62:2129-39. 2012
    ..the question whether EEG-microstate features are altered in different stages of NREM sleep compared to wakefulness. 32-channel EEG of 32 subjects in relaxed wakefulness and NREM sleep was analyzed using a clustering algorithm, ..
  65. ncbi Age-related changes in the circadian and homeostatic regulation of human sleep
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinics, Basel, Switzerland
    Chronobiol Int 23:461-74. 2006
    ..we favor the hypothesis that age-related changes in sleep are due to weaker circadian regulation of sleep and wakefulness. Our data suggest that manipulations of the circadian timing system, rather than the sleep homeostat, may offer ..
  66. ncbi The process of awakening: a PET study of regional brain activity patterns mediating the re-establishment of alertness and consciousness
    Thomas J Balkin
    Department of Behavioral Biology, Walter Reed Army Institute of Research, Washington, DC 20307 5100, USA
    Brain 125:2308-19. 2002
    ..Across the ensuing 15 min of wakefulness, further increases in CBF were evident primarily in anterior cortical regions, suggesting that the dissipation ..
  67. pmc Mapping resting-state brain networks in conscious animals
    Nanyin Zhang
    Center for Comparative NeuroImaging CCNI, Department of Psychiatry, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, United States
    J Neurosci Methods 189:186-96. 2010
    ....
  68. ncbi Experience-dependent changes in cerebral activation during human REM sleep
    P Maquet
    Cyclotron Research Centre, University of Liege, Belgium
    Nat Neurosci 3:831-6. 2000
    ..Several brain areas activated during the execution of a serial reaction time task during wakefulness were significantly more active during REM sleep in subjects previously trained on the task than in non-trained ..
  69. pmc Arousal effect of orexin A depends on activation of the histaminergic system
    Z L Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Japan
    Proc Natl Acad Sci U S A 98:9965-70. 2001
    ..Here we provide several lines of evidence that orexin A induces wakefulness by means of the TMN and histamine H(1) receptor (H1R)...
  70. ncbi Automatic sleep/wake identification from wrist activity
    R J Cole
    Department of Psychiatry, University of California, San Diego
    Sleep 15:461-9. 1992
    The purpose of this study was to develop and validate automatic scoring methods to distinguish sleep from wakefulness based on wrist activity...
  71. ncbi Circadian temperature and melatonin rhythms, sleep, and neurobehavioral function in humans living on a 20-h day
    J K Wyatt
    Circadian, Neuroendocrine and Sleep Disorders Section, Division of Endocrinology, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol 277:R1152-63. 1999
    ..This wake-dependent deterioration of neurobehavioral functions can be offset by the circadian drive for wakefulness, which peaks in the latter half of the habitual waking day during entrainment...
  72. ncbi Functional imaging of working memory after 24 hr of total sleep deprivation
    Michael W L Chee
    Cognitive Neuroscience Laboratory, SingHealth Research Laboratories, Singapore 169611, Singapore
    J Neurosci 24:4560-7. 2004
    ..Our findings provide neural correlates to explain why task performance in relatively more complex tasks is better preserved relative to simpler ones after SD...
  73. ncbi Sustained attention performance during sleep deprivation: evidence of state instability
    S M Doran
    Division of Sleep and Chronobiology, Department of Psychiatry, Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, 1013 Blockley Hall, 423 Guardian Drive, Philadelphia, Pennsylvania 19104, USA
    Arch Ital Biol 139:253-67. 2001
    ..subjects also had increasingly greater performance variability as a function of time on task after 18 hours of wakefulness. During sleep deprivation, variability in PVT performance reflected a combination of normal timely responses, ..
  74. ncbi Localized and lateralized cerebral glucose metabolism associated with eye movements during REM sleep and wakefulness: a positron emission tomography (PET) study
    C C Hong
    Department of Psychiatry, University of California, San Diego, La Jolla 92093-0603, USA
    Sleep 18:570-80. 1995
    ..Our results show that the same cortical areas are involved in eye movements in both REM sleep and wakefulness and suggest that REM sleep eye movements are saccadic scans of targets in the dream scene...
  75. ncbi To eat or to sleep? Orexin in the regulation of feeding and wakefulness
    J T Willie
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, 75390 9050, USA
    Annu Rev Neurosci 24:429-58. 2001
    ..throughout the central nervous system (CNS) to nuclei known to be important in the control of feeding, sleep-wakefulness, neuroendocrine homeostasis, and autonomic regulation...
  76. pmc Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice
    Koh Sasaki
    Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Japan
    PLoS ONE 6:e20360. 2011
    Hypothalamic neurons expressing neuropeptide orexins are critically involved in the control of sleep and wakefulness. Although the activity of orexin neurons is thought to be influenced by various neuronal input as well as humoral ..
  77. pmc Mammalian circadian biology: elucidating genome-wide levels of temporal organization
    Phillip L Lowrey
    Howard Hughes Medical Institute, Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    Annu Rev Genomics Hum Genet 5:407-41. 2004
    ....
  78. pmc insomniac and Cullin-3 regulate sleep and wakefulness in Drosophila
    Nicholas Stavropoulos
    Laboratory of Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuron 72:964-76. 2011
    ..The extensive evolutionary conservation of insomniac and Cul3 suggests that protein degradation pathways may have a general role in governing the sleep and wakefulness of animals.
  79. ncbi Cholinergic basal forebrain neurons burst with theta during waking and paradoxical sleep
    Maan Gee Lee
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    J Neurosci 25:4365-9. 2005
    ..Through their maximal firing and rhythmic theta discharge during active waking and paradoxical sleep, the cholinergic neurons can thus modulate the cortex to promote activation along with plasticity during these two states...
  80. ncbi Internal brain state regulates membrane potential synchrony in barrel cortex of behaving mice
    James F A Poulet
    Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Nature 454:881-5. 2008
    ..somatosensory barrel cortex in behaving mice, that the V(m) of nearby neurons is highly correlated during quiet wakefulness. However, when the mouse is whisking, an internally generated state change reduces the V(m) correlation, ..
  81. ncbi Lasting syndrome of depression produced by reduction in serotonin uptake during postnatal development: evidence from sleep, stress, and behavior
    Daniela Popa
    Universite Pierre et Marie Curie Paris 6, Unité Mixte de Recherche S677, F 75013 Paris, France
    J Neurosci 28:3546-54. 2008
    ..the impact of early-life, transient versus genetic, permanent alterations of serotonin reuptake on sleep-wakefulness patterns, depression-related behavior, and associated physiological features...
  82. pmc Large ventral lateral neurons modulate arousal and sleep in Drosophila
    Vasu Sheeba
    Department of Physiology and Biophysics, University of California, Irvine, California 92697, USA
    Curr Biol 18:1537-45. 2008
    ..exhibit higher daytime-light-driven spontaneous action-potential firing rates in Drosophila, coinciding with wakefulness and locomotor-activity behavior...
  83. pmc Selective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture
    Taizo Matsuki
    Yanagisawa Orphan Receptor Project, ERATO, Japan Science and Technology Agency, Saitama 322 0012 Japan
    Proc Natl Acad Sci U S A 106:4459-64. 2009
    ..Thus, GABA(B) receptors on orexin neurons are crucial in the appropriate control of the orexinergic tone through sleep/wake states, thereby stabilizing the state switching mechanisms...
  84. ncbi A mathematical model of the sleep/wake cycle
    Michael J Rempe
    Mathematical Biosciences Institute, Ohio State University, Columbus, OH 43210, USA
    J Math Biol 60:615-44. 2010
    ..These features include the timing of sleep and wakefulness under normal and sleep-deprived conditions, ultradian rhythms, more frequent switching between sleep and ..
  85. ncbi Stress response genes protect against lethal effects of sleep deprivation in Drosophila
    Paul J Shaw
    The Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, California 92121, USA
    Nature 417:287-91. 2002
    ..These data represent the first step in identifying the molecular mechanisms that constitute the sleep homeostat...
  86. pmc Identification of a neural circuit that underlies the effects of octopamine on sleep:wake behavior
    Amanda Crocker
    Department of Neuroscience, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    Neuron 65:670-81. 2010
    ..These studies define the cellular and molecular basis of octopamine action and suggest that the PI is a sleep:wake-regulating neuroendocrine structure like the mammalian hypothalamus...
  87. ncbi Reverse replay of behavioural sequences in hippocampal place cells during the awake state
    David J Foster
    Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 46 5223, Cambridge, Massachusetts 02139, USA
    Nature 440:680-3. 2006
    ..This replay is suggestive of a role in the evaluation of event sequences in the manner of reinforcement learning models. We propose that such replay might constitute a general mechanism of learning and memory...
  88. ncbi Sleep facilitates consolidation of emotional declarative memory
    Peter Hu
    Sleep and Neuroimaging Laboratory, Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Psychol Sci 17:891-8. 2006
    ..These findings hold important implications for understanding of human memory processing, suggesting that the facilitation of memory for emotionally salient information may preferentially develop during sleep...
  89. pmc Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice
    Michihiro Mieda
    Department of Molecular Genetics and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 9050, USA
    Proc Natl Acad Sci U S A 101:4649-54. 2004
    Narcolepsy-cataplexy is a neurological disorder associated with the inability to maintain wakefulness and abnormal intrusions of rapid eye movement sleep-related phenomena into wakefulness such as cataplexy...
  90. ncbi Global forebrain dynamics predict rat behavioral states and their transitions
    Damien Gervasoni
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 24:11137-47. 2004
    ....
  91. ncbi Differential expression of plasticity-related genes in waking and sleep and their regulation by the noradrenergic system
    C Cirelli
    The Neurosciences Institute, San Diego, California 92121, USA
    J Neurosci 20:9187-94. 2000
    ..These molecular results complement behavioral evidence and provide a mechanism for the impairment of long-term memory acquisition during sleep...
  92. ncbi Exploratory behavior, cortical BDNF expression, and sleep homeostasis
    Reto Huber
    Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
    Sleep 30:129-39. 2007
    ..eye movement (NREM) sleep is a reliable indicator of sleep need, as it increases with the duration of prior wakefulness and decreases during sleep...
  93. ncbi Sleep-dependent motor memory plasticity in the human brain
    M P Walker
    Sleep and Neuroimaging Laboratory, FD Feldberg 862, Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Neuroscience 133:911-7. 2005
    ..This evidence of an overnight, systems-level change in the representation of a motor memory holds important implications for acquiring real-life skills and in clinical rehabilitation following brain trauma, such as stroke...
  94. ncbi Functional magnetic resonance imaging-assessed brain responses during an executive task depend on interaction of sleep homeostasis, circadian phase, and PER3 genotype
    Gilles Vandewalle
    Cyclotron Research Centre, University of Liege, B 4000 Liege, Belgium
    J Neurosci 29:7948-56. 2009
    ..The findings support a model of individual differences in executive control, in which the allocation of prefrontal resources is constrained by sleep pressure and circadian phase...
  95. pmc Aging and nocturnal driving: better with coffee or a nap? A randomized study
    Patricia Sagaspe
    Clinique du Sommeil, CHU Pellegrin, Bordeaux, France
    Sleep 30:1808-13. 2007
    ..To test the effects of coffee and napping on nocturnal driving in young and middle-aged participants...
  96. ncbi The cortisol awakening response: more than a measure of HPA axis function
    Angela Clow
    Psychophysiology and Stress Research Group, Department of Psychology, University of Westminster, London, UK
    Neurosci Biobehav Rev 35:97-103. 2010
    ..An association between the CAR and the ending of sleep inertia is discussed...
  97. pmc Mathematical model of network dynamics governing mouse sleep-wake behavior
    Cecilia G Diniz Behn
    Department of Mathematics and Center for BioDynamics, Boston University, MA, USA
    J Neurophysiol 97:3828-40. 2007
    ..between brief and sustained wake bouts, the model suggests distinct network mechanisms for the two types of wakefulness. Because circadian and other factors alter the fine architecture of sleep-wake behavior, this model provides a ..
  98. pmc Orexin/hypocretin and histamine: distinct roles in the control of wakefulness demonstrated using knock-out mouse models
    Christelle Anaclet
    INSERM U628, Integrated Physiology of Brain Arousal Systems, IFR19, 69373 Lyon, France
    J Neurosci 29:14423-38. 2009
    To determine the respective role played by orexin/hypocretin and histamine (HA) neurons in maintaining wakefulness (W), we characterized the behavioral and sleep-wake phenotypes of orexin (Ox) knock-out (-/-) mice and compared them with ..
  99. ncbi State-specific effects of sevoflurane anesthesia on sleep homeostasis: selective recovery of slow wave but not rapid eye movement sleep
    Dinesh Pal
    Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan 48109 5048, USA
    Anesthesiology 114:302-10. 2011
    ..In the current study, the effects of sevoflurane on recovery from total sleep deprivation were investigated...
  100. ncbi Heart-rate variability in women during 40-hour prolonged wakefulness
    Doreen Anders
    Thermophysiological Chronobiology, Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland
    Chronobiol Int 27:1609-28. 2010
    Heart-rate variability patterns of 18 women during a 40-h constant routine of prolonged wakefulness under controlled laboratory conditions were analyzed...
  101. ncbi Analysis of the QTL for sleep homeostasis in mice: Homer1a is a likely candidate
    M MacKiewicz
    Department of Medicine, Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Translational Research Laboratories, Philadelphia, PA 19104 3403, USA
    Physiol Genomics 33:91-9. 2008
    ..We established the expression pattern of selected genes located in the Dps1 interval in sleep and wakefulness in B6 and D2 parental strains...

Research Grants75

  1. CAUSES OF SLEEP-INDUCED BREATHING INSTABILITIES
    Jerome Dempsey; Fiscal Year: 2002
    During sleep and with the loss of the "wakefulness" drive to pump and upper airway respiratory muscles, the control of breathing becomes highly dependent upon and vulnerable to reflexive feedback inputs from chemoreceptors and ..
  2. OREXIN AND THE CONTROL OF SLEEP AND WAKEFULNESS
    ROBERT MC CARLEY; Fiscal Year: 2005
    ..mouse knock-out experiments link to cataplexy/narcolepsy, which may be regarded as disorders of REM sleep and wakefulness. Indeed, orexin neurons in the lateral hypothalamus have widespread projections to regions important in control ..
  3. Adenosine and the Basal Forebrain in the Control of Behavioral State
    Robert E Strecker; Fiscal Year: 2012
    ..Cage motion is used to produce the periods of wakefulness. Rats adapt readily to this procedure and show no signs of discomfort or stress...
  4. Cerebral metabolism, EEG, and sleep cycling in critically ill neonates
    Renée A Shellhaas; Fiscal Year: 2013
    ..Aims: 1) Perform cross-channel analyses of NIRS and EEG in 50 critically ill neonates during wakefulness, active and quiet sleep...
  5. Respiratory and autonomic plasticity following intermittent hypoxia
    JASON HAROLD MATEIKA; Fiscal Year: 2012
    ..administration of an antioxidant cocktail impacts of respiratory and autonomic nervous system plasticity during wakefulness and sleep following IH...
  6. SYSTEM FOR AUTOMATED NONINVASIVE MONITORING OF MOUSE SLEEP AND BEHAVIOR
    Sridhar Sunderam; Fiscal Year: 2013
    ..a pressure- sensitive piezoelectric sensor attached to the cage floor, and can already discriminate sleep from wakefulness with high accuracy and track changes in respiratory effort when the animal is relatively inactive...
  7. The upper airway and the Sudden Infant Death Syndrome
    Donald Bartlett; Fiscal Year: 2012
    ..We will also study intact, chronically instrumented piglets during wakefulness, NREM and REM sleep to determine the combined influence on the LCR of hyperthermia and manipulation of central ..
  8. CHOLINERGIC MECHANISMS OF REM SLEEP GENERATION
    Helen A Baghdoyan; Fiscal Year: 2013
    ..for generating the cortical activation needed for attentional, learning, and memory functions of normal wakefulness, and schizophrenia and bipolar disorder are characterized by alterations in cortical activity and by sleep ..
  9. Basal Forebrain Cellular Mechanisms of Cortical Activation
    Robert W McCarley; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): How do the states of wakefulness and sleep enhance the processing of information? The answer to this question involves the ability of the brain to synchronize the activities of assemblies of neurons ..
  10. Orexin Receptor Agonists for the Treatment of Excessive Daytime Sleepiness and Ca
    PAUL STUART HUMPHRIES; Fiscal Year: 2013
    ..these medications are effective, due to potential for addiction and negative side effects, newer nonstimulant wakefulness medications are preferred (e.g. modafinil)...
  11. Molecular-Genetic Dissection of Basal Forebrain Circuitry Regulating Arousal
    PATRICK MICHAEL FULLER; Fiscal Year: 2013
    ..processes including, cognition, learning, memory and attention, virtually all of which operate on a basis of wakefulness. Dysfunction of BF circuitry is also implicated in the pathogenesis of a host of neuropsychiatric and ..
  12. Hypocretin and Locus Ceruleus Interactions in Zebrafish Development and Behavior
    Grigorios Oikonomou; Fiscal Year: 2012
    ..Activity in these centers is correlated with wakefulness and stimulation of either cluster increases the probability of waking in sleeping mice...
  13. Integration of Feeding and Glucose Metabolism by the Circadian Gene Network
    JOSEPH T BASS; Fiscal Year: 2013
    ..evidence for a new risk factor in obesity and type 2 diabetes mellitus: introduction of extended periods of wakefulness in the workplace and at home giving rise to temporal disruption between the external environment and internal ..
  14. Cellular Mechanisms for the hormonal Modulation of Sleep
    Jessica Mong; Fiscal Year: 2009
    ..D2 and gamma-amino butyric acid (GABA), in key brain nuclei that are involved in the regulation of sleep and wakefulness. Numerous sleep surveys report women experience considerably more sleep problems than men...
  15. CONNECTIONS OF THE LIMBIC SYSTEM AND HYPOTHALAMUS
    Larry W Swanson; Fiscal Year: 2012
    ..sexual behavior and physiology (for example, the menstrual cycle), and disturbances of normal sleep and wakefulness patterns...
  16. Effects of chronic sleep restriction on energy homeostasis in healthy adults
    ANDREA MARIE SPAETH; Fiscal Year: 2013
    ..Additionally, studies show that extended wakefulness due to sleep loss causes changes in resting metabolic rate, diet induced thermogenesis and physical activity, ..
  17. Prediction of Physiological Events in People with Sleep Disordered Breathing
    Jonathan A Waxman; Fiscal Year: 2011
    ..The second aim is to predict the onset of unintended daytime sleep while subjects undergo maintenance of wakefulness tests, which assess one's ability to resist sleep in a soporific condition...
  18. Volatile Anesthetic Regulation of TASK Tandem Pore Potassium Channels
    Joseph F Cotten; Fiscal Year: 2012
    ..TASK-3 function is also inhibited by GqPCR activation. GqPCRs in the CNS regulate memory, wakefulness, and consciousness and peripherally are important regulators of smooth muscle tone...
  19. Sleep Disruption and Mild Cognitive Impairment in Veterans
    CYNTHIA HOLDEN PHELAN; Fiscal Year: 2013
    ..brain function as they minimize many factors that may interfere with assessing cognitive function during wakefulness, (e.g., a subject's intelligence, attention, and/or motivation)...
  20. Neuropeptidomics of Clock-to-Clock Coupling
    Martha U Gillette; Fiscal Year: 2010
    ..tissue functions lose temporal coherence as well as appropriate alignment to the daily cycle of sleep and wakefulness. Little is known about what couples an organism's circadian clocks, except that diffusible factors are ..
  21. Hypocretin and its receptors Gene Transfer for Narcolepsy
    Meng Liu; Fiscal Year: 2013
    ..my vision is that it can also be used to treat specific symptoms of narcolepsy and other disorders of sleep and wakefulness. Results of this project will serve as a strong base for discovering better alternative treatments for human ..
  22. The Role Leptin on Arousal
    PAIGE B BECK; Fiscal Year: 2013
    ..leptin is known to be an active regulator in the hypothalamus, the hormone's role in the PPN (and thus in wakefulness) is not established...
  23. Interleukin-1: A Promoter of Slow Wave Sleep
    JAMES MARTIN KRUEGER; Fiscal Year: 2013
    ..For over 100 years it has been known that prolonged wakefulness (W) enhances brain production and release of sleep regulatory substances (SRSs)...
  24. Functional Connectivity of the Hypocretin/Orexin System
    Thomas S Kilduff; Fiscal Year: 2013
    ..neurons and the serotonergic dorsal raphe nucleus has functional significance for the regulation of sleep and wakefulness. Lastly, we will exploit a newly created transgenic mouse in which conditional expression of diphtheria toxin A ..
  25. NEURONAL BASIS UNDERLYING VOLATILE ANESTHETIC INDUCED HYPNOSIS
    MAX KELZ; Fiscal Year: 2013
    ..physiological unconsciousness, such as sleep, in which the patient is locked out of access to the state of wakefulness. To determine whether existing volatile anesthetics cause their desirable hypnotic effects through interactions ..
  26. Arousal, orexins and anesthesia
    MAX KELZ; Fiscal Year: 2010
    ..is that inhaled anesthetics exert specific effects upon the endogenous neural circuitry regulating sleep and wakefulness. During induction and maintenance of anesthesia, we hypothesize that inhaled anesthetics produce their hypnotic ..
  27. Optogenetic Control of Vigilance State Transition
    Luis de Lecea; Fiscal Year: 2013
    ..we will use optogenetic manipulation of Hcrt neurons to test whether phasic activity of these neurons during wakefulness is sufficient to stabilize arousal...
  28. Quantification of the State-Dependent Inputs to Hypoglossal Motoneurons
    VICTOR BORISOVICH FENIK; Fiscal Year: 2010
    ..In order to understand the responsible mechanisms, we will use intracellular recording during natural sleep and wakefulness. The following Specific Aims will be conducted: (1) to determine the contribution of postsynaptic inhibition ..
  29. Development of Small Molecule Orexin Receptor Agonists for Treating Narcolepsy
    Masashi Yanagisawa; Fiscal Year: 2010
    ..Narcolepsy is a debilitating disorder characterized by an inability to properly maintain wakefulness, sleep attacks, a sudden loss of muscle function, and sleep paralysis...
  30. Upper airway control during disrupted and misaligned sleep
    LESZEK K KUBIN; Fiscal Year: 2013
    ..contraction of upper airway muscles allows OSA patients to keep the airway open and breathe adequately during wakefulness but is insufficient during sleep;hence sleep-disordered breathing occurs...
  31. Circadian light entrainment following genetic ablation of retinal glutamate trans
    HEINRICH SELWYN GOMPF; Fiscal Year: 2010
    ..work can make it difficult for humans to receive these synchronizing inputs and this can impact arousal and wakefulness;moreover certain disorders such as seasonal affective disorders are also linked to light inputs to the master ..
  32. PREMOTOR CONTROL OF UPPER AIRWAY AND REM SLEEP ATONIA
    LESZEK K KUBIN; Fiscal Year: 2012
    ..We hypothesize that the A1 group contributes to the increased levels of activity in upper airway muscles during wakefulness, a well established adaptation in OSAS that may be caused by the chronic-intermittent hypoxia(CIH) that OSAS ..
  33. Synaptic Mechanisms of Hypothalamic Control of Vigilance and Cognitive Function
    ALEXANDER CHOI JACKSON; Fiscal Year: 2013
    ..mechanisms through which hypothalamic neural circuits regulate fundamental behavioral states, such as sleep, wakefulness, attention and cognition, in health and disease. Dr...
  34. Serotonin neurons in arousal, epilepsy and SUDEP.
    GORDON FRANK BUCHANAN; Fiscal Year: 2013
    ..the role of 5-HT neurons, especially in their capacity as central chemoreceptors, in the regulation of sleep-wakefulness and breathing following a seizure...
  35. Neural circuits underlying circadian regulation of behavior and physiology
    Nina Vujovic; Fiscal Year: 2012
    ..lesions of the DMH produce a significant reduction in the amplitude of circadian rhythms of locomotor activity, wakefulness, corticosteroid secretion and feeding...
  36. Neurobiological Mechanisms of Sympathetic Regulation in Sleep Apnea
    Anne M Fink; Fiscal Year: 2013
    ..and chronic intermittent hypoxia (CIH) on CV function across behavioral states (non-REM sleep, REM sleep, and wakefulness) in rats...
  37. CSF and the central chemical control of breathing.
    Eugene Edward Nattie; Fiscal Year: 2013
    ..We propose that in wakefulness, the orexin neurons of the LH excite serotonergic neurons of the MR and both contribute to chemoreception via ..
  38. Targeted Therapies for Selected Phenotypes of Obstructive Sleep Apnea
    Jerome A Dempsey; Fiscal Year: 2010
    ..Arousal and wakefulness are likely required for airway patency in these patients...
  39. Role of Neuropeptide S in age-related cognitive decline
    Olivier Civelli; Fiscal Year: 2012
    ..Neuropeptide S (NPS) is a recently identified transmitter in the brain. NPS produces arousal and wakefulness and reduces behavioral signs of anxiety in rodents...
  40. Purinergic Mechanisms in Homeostatic Sleep Control
    Radhika Basheer; Fiscal Year: 2013
    ..waking beyond its natural duration leads to a homeostatic sleep response based on the duration of prior wakefulness. Increases in homeostatic sleep response are associated with increased sleepiness and decreased alertness...
  41. Investigating Genetics of Human Natural Short Sleepers
    Ying Hui Fu; Fiscal Year: 2013
    ..pacemaker (the clock) ticking with periodicity of ~24 hours, and a homeostatic drive that increases during wakefulness and dissipates during sleep...
  42. Genetic dissection of sleep regulation by ventrolateral preoptic area
    Vetrivelan Ramalingam; Fiscal Year: 2013
    ..and around the VLPO region, and thus the effect of selectively lesioning the galaninergic VLPO neurons on sleep-wakefulness is not known...
  43. Neural Mechanisms of Diurnality: Role of the Intergeniculate Leaflet
    ANDREW JASON GALL; Fiscal Year: 2013
    ..coordination of many aspects of circadian behavior and physiology, including daily activity patterns, sleep, wakefulness, temperature regulation, and stress...
  44. Adenosine, Hypocretin and Sleep Disorder Comorbidities Associated with Epilepsy
    Kristina A Simeone; Fiscal Year: 2013
    ..Hypocretin neurons are located in the lateral hypothalamus and stimulate arousal nuclei to elicit wakefulness and in sleep disorders, trigger inappropriate awakenings...
  45. Locus Coeruleus Function and Methylphenidate Action
    BARRY DALE WATERHOUSE; Fiscal Year: 2013
    ..system function and psychostimulant drug action but will also provide insight regarding the pathology of ADHD and the motivation for off-label use of this class of drugs to promote wakefulness and enhance cognition in healthy subjects.
  46. Upstream control and downstream effects of NPS release
    Olivier Civelli; Fiscal Year: 2013
    ..NPS produces arousal and wakefulness and reduces behavioral signs of anxiety in rodents...
  47. Multi-Center Trial of Limiting PGY2&3 Resident Work Hours on Patient Safety-CCC
    CHRISTOPHER PAUL LANDRIGAN; Fiscal Year: 2013
    ..that "the scientific evidence base establishes that human performance begins to deteriorate after 16 hours of wakefulness," and called for the elimination of all resident-physician shifts without sleep exceeding 16 hours...
  48. Limbic modulation of stress-induced alterations in sleep
    Larry D Sanford; Fiscal Year: 2013
    ..Fear learning associated with uncontrollable stress produces overt fear behavior in wakefulness (freezing in rodents) and decreases REM sleep whereas fear learning associated with controllable stress ..
  49. Sleep, proprioception, and forebrain activity in infant mutant mice
    MARK SAMUEL BLUMBERG; Fiscal Year: 2013
    ..neurophysiological activity in unanesthetized infant rats as they cycle spontaneously between sleep and wakefulness and respond to experimenter-controlled delivery of peripheral tactile and proprioceptive stimuli, we will ..
  50. Genetic Approaches to Sleep/Wake and Response to Sleep Loss in Mice
    ALLAN IAN PACK; Fiscal Year: 2013
    ..In addition, the normal duration of wakefulness that a mouse can sustain will also be simultaneously assessed...
  51. Hypersomnia in Major Depressive Disorder: a high-density EEG investigation
    David T Plante; Fiscal Year: 2013
    ..Dr. Plante's goals are to examine the neurophysiology of hypersomnolence in depression during sleep and wakefulness, to identify biomarkers for excessive sleepiness, and to ultimately translate these findings into targeted ..
  52. A Rodent Model of Compromised Upper Airway
    LESZEK K KUBIN; Fiscal Year: 2010
    ..To maintain adequate breathing during wakefulness, OSA patients adapt to the compromised anatomy of their upper airway, but the mechanisms underlying this ..
  53. Optogenetic dissection of basal forebrain neurons involved in sleep homeostasis
    Radhika Basheer; Fiscal Year: 2013
    ..One of the brain regions, the basal forebrain (BF), in addition to its important role in promoting wakefulness, is also recognized for its role i homeostatic sleep regulation as well as in attention and cognition...
  54. Mechanisms that regulate zebrafish Hypocretin neuron development and function
    DAVID AARON PROBER; Fiscal Year: 2013
    ..disorders are associated with narcolepsy, indicating that additional genes and neurons that control sleep and wakefulness remain to be identified...
  55. Model-based Phenotyping of OSAS in Pediatric Obesity using Dynamic MR Imaging
    Michael C K Khoo; Fiscal Year: 2013
    ..from dynamic magnetic resonance imaging (MRI) and noninvasive physiological measurements obtained during wakefulness and sleep;(2) estimate from these data the key parameters of a closed-loop minimal computational model of SRBD ..
  56. "Synaptic Modulation of Mesopontine Cholingergic Neurons"
    Christopher S Leonard; Fiscal Year: 2013
    ..excessive daytime sleepiness, sleep fragmentation and the intrusion of rapid eye movement sleep behaviors into wakefulness. Building on the findings from previous funding periods, which showed that mesopontine cholinergic neurons and ..
  57. Genetic Analysis of Nematode Egg Laying and Co-regulated Behavioral Systems
    H Robert Horvitz; Fiscal Year: 2013
    ..in many aspects of human physiology, including reproduction, growth, metabolism, sleep and memory as well as in the assumption of one of two alternative behavioral states, such as hunger-satiety, sleep-wakefulness and monogamy-polygamy.
  58. Synaptic Mechanisms of Hypothalamic Control of Vigilance and Cognitive Function
    ALEXANDER CHOI JACKSON; Fiscal Year: 2013
    ..mechanisms through which hypothalamic neural circuits regulate fundamental behavioral states, such as sleep, wakefulness, attention and cognition, in health and disease. Dr...
  59. Synaptic Modulation in Neural Circuits
    Jing W Wang; Fiscal Year: 2013
    ..In Aims 2 and 3, we will test the hypothesis that serotonin, a neuromodulator associated with arousal and wakefulness, promotes contrast enhancement and functions to enhance feature in a noisy odor environment...
  60. Rodent Behavioral Model of Ongoing Headache Pain
    ANDREW MARK STRASSMAN; Fiscal Year: 2013
    ..of the normal exploratory behavior, and a concomitant increase in the amount of "resting'behavior or quiet wakefulness. This may be considered an example of the more general phenomenon of suppression of an innate behavior/..
  61. COORDINATION OF CIRCADIAN PHYSIOLOGY OF DIVERSE SPECIES
    Deborah Bell Pedersen; Fiscal Year: 2010
    ..the way to a comprehensive systems biology approach to biological clocks that will elucidate chronobiological disorders associated with sleep and wakefulness, many of which are attended by metabolic, endocrine, and cell-cycle disorders.
  62. Inhaled Fluticasone Effects on Upper Airway Patency in Obstructive Lung Disease
    Mihaela Teodorescu; Fiscal Year: 2013
    ..because it will directly evaluate the effects of ICS on the UAW structure and function during sleep and wakefulness. At the study completion, it is our expectation that we will have elucidated the effects and governing ..
  63. Roles of peripheral and central respiratory chemoreceptors in inbred rat strains
    MATTHEW ROBERT HODGES; Fiscal Year: 2013
    ..pathways for pH? Which neurons perform this task? Under which circumstances are they important (sleep wakefulness)? The overall goals of this proposal are to address some of these questions regarding central chemoreception by ..
  64. Neurobiology of PTSD During REM Sleep
    Anne Germain; Fiscal Year: 2010
    ..They will complete simultaneous polysomnographic (sleep) and PET studies during morning wakefulness and REM according to validated procedures...
  65. Circadian and Aminergic Regulation of Orexin Neurons
    THOMAS SCAMMELL; Fiscal Year: 2005
    ..People with narcolepsy have difficulty maintaining wakefulness and often have intrusions of REM sleep-like phenomena into wakefulness...
  66. ELECTROPHYSIOLOGY & PHARMACOLOGY OF SLEEP-WAKEFULNESS
    Mahesh Thakkar; Fiscal Year: 2004
    ..The experiments described in this proposal focus on understanding of sleep and wakefulness at the cellular level...
  67. Orexins in Rapid Eye Movement Sleep Control.
    Mahesh Thakkar; Fiscal Year: 2009
    Orexins/Hypocretins are hypothalamic neuropeptides that are critical for normal sleep-wakefulness. There is considerable evidence linking orexins to cataplexy/narcolepsy, which may be regarded as REM sleep disorders...
  68. Amygdalar Modulation of Fear-Conditioned Changes in REM Sleep
    ADRIAN MORRISON; Fiscal Year: 2009
    ..shall study changes in REM sleep (REM) after fear conditioning in rats, and related behavioral changes during wakefulness (W). In the current proposal, we focus on the lateral nucleus (LA) of AMY...
  69. Sleep Activity Patterns and Temperature in Childhood Onset Bipolar Disorder
    Patricia Murphy; Fiscal Year: 2009
    ..disorder (COBD), in particular, is characterized by symptoms suggestive of altered regulation of sleep and wakefulness. An associated clinical observation is that children with bipolar disorder exhibit problems with heat ..
  70. CARDIORESPIRATORY TRANSFER IN OBSTRUCTIVE SLEEP APNEA
    MICHAEL KHOO; Fiscal Year: 2000
    ..effects of respiration on heart rate control in subjects with obstructive sleep apnea syndrome (OSAS) during wakefulness and sleep...
  71. The Roles of Neuropeptide S System in the Regulation of Sleep and Wakefulness
    Yanling Xu; Fiscal Year: 2007
    ..Neuropeptide S (NPS) and it receptor are a newly discovered neuropeptide system that promotes arousal and wakefulness. Our previous studies have shown that central administration of NPS dramatically induces wakefulness, ..
  72. STATE DEPENDENT CONTROL OF MOTORNEURON ACTIVITY
    Michael Chase; Fiscal Year: 2004
    ..These patterns of behavior are evidenced, for example, during wakefulness by cataplectic attacks, in which the motor inhibition that normally occurs during active (REM) sleep is ..
  73. Pain, Opioids, and Sleep in Cancer Patients
    Kathy Parker; Fiscal Year: 2006
    ..Therefore, pain and opioids can be viewed as two factors independently affecting nighttime sleep daytime wakefulness while also interacting with each other...
  74. Probing of Hypothalamic circuits in arousal using optogenetics
    Antoine Adamantidis; Fiscal Year: 2009
    ..a matter of debate and may include memory consolidation and plasticity, the neural substrates of sleep and wakefulness are the subject of intense study...