- The memory function of sleep
University of Lubeck, Department of Neuroendocrinology, 23538 Lubeck, Germany
Nat Rev Neurosci 11:114-26. 2010
- A new method for measuring daytime sleepiness: the Epworth sleepiness scale
M W Johns
Sleep Disorders Unit, Epworth Hospital, Melbourne, Victoria, Australia
Sleep 14:540-5. 1991
..ESS scores of patients who simply snored did not differ from controls...
- Hypothalamic regulation of sleep and circadian rhythms
Clifford B Saper
Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, USA
Nature 437:1257-63. 2005
..has begun to identify the brain circuitry and neurotransmitters that regulate our daily cycles of sleep and wakefulness. The latter depends on a network of cell groups that activate the thalamus and the cerebral cortex...
- Breakdown of cortical effective connectivity during sleep
Department of Psychiatry, University of Wisconsin, Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA
Science 309:2228-32. 2005
..During quiet wakefulness, an initial response (approximately 15 milliseconds) at the stimulation site was followed by a sequence of ..
- Control of sleep and wakefulness
Ritchie E Brown
Laboratory of Neuroscience, VA Boston Healthcare System and Harvard Medical School, Brockton, Massachusetts 02301, USA
Physiol Rev 92:1087-187. 2012
This review summarizes the brain mechanisms controlling sleep and wakefulness. Wakefulness promoting systems cause low-voltage, fast activity in the electroencephalogram (EEG)...
- Sleep state switching
Clifford B Saper
Department of Neurology, Program in Neuroscience, and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Neuron 68:1023-42. 2010
We take for granted the ability to fall asleep or to snap out of sleep into wakefulness, but these changes in behavioral state require specific switching mechanisms in the brain that allow well-defined state transitions...
- Local sleep and learning
Department of Psychiatry, University of Wisconsin, Madison, Wisconsin 53719, USA
Nature 430:78-81. 2004
..The amount of SWA is homeostatically regulated, increasing after wakefulness and returning to baseline during sleep...
- Imaging large-scale neural activity with cellular resolution in awake, mobile mice
Daniel A Dombeck
Department of Molecular Biology, Carl Icahn Labs, Princeton University, Princeton, NJ 08544, USA
Neuron 56:43-57. 2007
..Behaviorally correlated calcium transients from large neuronal and astrocytic populations were routinely measured, with an estimated motion-induced false positive error rate of <5%...
- The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness
Department of Pharmacology, Institute of Basic Medical Science, University of Tsukuba, Ibaraki 305 8575, Japan
Nat Rev Neurosci 8:171-81. 2007
Sleep and wakefulness are regulated to occur at appropriate times that are in accordance with our internal and external environments...
- Correlates of sleep and waking in Drosophila melanogaster
P J Shaw
The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
Science 287:1834-7. 2000
..These results implicate the catabolism of monoamines in the regulation of sleep and waking in the fly and suggest that Drosophila may serve as a model system for the genetic dissection of sleep...
- Neural substrates of awakening probed with optogenetic control of hypocretin neurons
Antoine R Adamantidis
Department of Psychiatry and Behavioral Sciences, Stanford University, 701B Welch Road, Palo Alto, California 94304, USA
Nature 450:420-4. 2007
..that direct, selective, optogenetic photostimulation of Hcrt neurons increased the probability of transition to wakefulness from either slow wave sleep or rapid eye movement sleep...
- Practice with sleep makes perfect: sleep-dependent motor skill learning
Matthew P Walker
Laboratory of Neurophysiology, Department of Psychiatry, Harvard Medical School, 74 Fenwood Road, Boston, Massachusetts 02115, USA
Neuron 35:205-11. 2002
..This finding of sleep-dependent motor skill improvement may have important implications for the efficient learning of all skilled actions in humans...
- Practice parameters for clinical use of the multiple sleep latency test and the maintenance of wakefulness test
Michael R Littner
VA Greater Los Angeles Healthcare System, CA, USA
Sleep 28:113-21. 2005
..sleep clinician on appropriate clinical use of the Multiple Sleep Latency Test (MSLT), and the Maintenance of Wakefulness Test (MWT)...
- Dynamic sensory representations in the olfactory bulb: modulation by wakefulness and experience
Hiroyuki K Kato
Center for Neural Circuits and Behavior and Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA
Neuron 76:962-75. 2012
..the brain influenced by the state of an animal? Here we use chronic two-photon calcium imaging to explore how wakefulness and experience shape odor representations in the mouse olfactory bulb...
- Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep
Vladyslav V Vyazovskiy
Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Blvd, Madison, Wisconsin 53719, USA
Nat Neurosci 11:200-8. 2008
Plastic changes occurring during wakefulness aid in the acquisition and consolidation of memories. For some memories, further consolidation requires sleep, but whether plastic processes during wakefulness and sleep differ is unclear...
- Development of the brain's default mode network from wakefulness to slow wave sleep
Philipp G Sämann
Max Planck Institute of Psychiatry, Neuroimaging Research Group, 80804 Munich, Germany
Cereb Cortex 21:2082-93. 2011
..network (DMN) and its anticorrelated network (ACN) that are involved in internal and external awareness during wakefulness. Using independent component analysis, cross-correlation analysis (CCA), and intraindividual dynamic network ..
- Odor cues during slow-wave sleep prompt declarative memory consolidation
Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160 23a, 23538 Lubeck, Germany
Science 315:1426-9. 2007
..Odor re-exposure was ineffective during rapid eye movement sleep or wakefulness or when the odor had been omitted during prior learning...
- Cortisol awakening response and psychosocial factors: a systematic review and meta-analysis
Psychobiology Group, Department of Epidemiology and Public Health, University College London, United Kingdom
Biol Psychol 80:265-78. 2009
..This review concludes that different psychosocial factors are associated with an enhanced or reduced cortisol awakening response...
- Direct evidence for wake-related increases and sleep-related decreases in synaptic strength in rodent cortex
Zhong Wu Liu
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Neurosci 30:8671-5. 2010
..Since stronger synapses require more energy, space, and supplies, a generalized renormalization of synapses may be an important function of sleep...
- The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation
Hans P A Van Dongen
Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, Department of Psychiatry, and Centerfor Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
Sleep 26:117-26. 2003
- Dissociable stages of human memory consolidation and reconsolidation
Matthew P Walker
Laboratory of Neurophysiology, Massachusetts Mental Health Center, Department of Psychiatry, Harvard Medical School, 74 Fenwood Road, Boston, Massachusetts 02115, USA
Nature 425:616-20. 2003
- Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle
Maan Gee Lee
Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, H3A 2B4, Canada
J Neurosci 25:6716-20. 2005
Although maintained by multiple arousal systems, wakefulness falters if orexin (hypocretin), orexin receptors, or orexin neurons are deficient; narcolepsy results with hypersomnolence or sudden onset of rapid eye movement sleep [or ..
- Acute optogenetic silencing of orexin/hypocretin neurons induces slow-wave sleep in mice
Division of Cell Signaling, National Institute for Physiological Sciences, Okazaki 444 8787, Japan
J Neurosci 31:10529-39. 2011
Orexin/hypocretin neurons have a crucial role in the regulation of sleep and wakefulness. To help determine how these neurons promote wakefulness, we generated transgenic mice in which orexin neurons expressed halorhodopsin (orexin/Halo ..
- Modeling sleep and wakefulness in the thalamocortical system
Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Boulevard, Madison, WI 53719 1176, USA
J Neurophysiol 93:1671-98. 2005
When the brain goes from wakefulness to sleep, cortical neurons begin to undergo slow oscillations in their membrane potential that are synchronized by thalamocortical circuits and reflected in EEG slow waves...
- Power density in theta/alpha frequencies of the waking EEG progressively increases during sustained wakefulness
Psychiatric University Clinic, Basel, Switzerland
Sleep 18:890-4. 1995
..power density and self-rated fatigue were assessed in nine healthy women during a 40-hour period of sustained wakefulness under constant behavioral and environmental conditions (constant routine protocol)...
- PER3 polymorphism predicts sleep structure and waking performance
Antoine U Viola
Surrey Sleep Research Centre, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, UK
Curr Biol 17:613-8. 2007
..EEG) slow-wave activity in non-rapid eye movement (non-REM) sleep and theta and alpha activity during wakefulness and REM sleep were all increased in PER3(5/5) compared to PER3(4/4) individuals...
- Play it again: reactivation of waking experience and memory
MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK
Trends Neurosci 33:220-9. 2010
..Although the mechanisms remain uncertain, there is a growing consensus that such SWR-directed reactivation of brain-wide memory traces could underlie memory consolidation...
- Sleep function and synaptic homeostasis
Department of Psychiatry, University of Wisconsin, 6001 Research Park Blvd, Madison, WI 53719, USA
Sleep Med Rev 10:49-62. 2006
..According to the hypothesis, plastic processes occurring during wakefulness result in a net increase in synaptic strength in many brain circuits...
- The sleep switch: hypothalamic control of sleep and wakefulness
C B Saper
Dept of Neurology, Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Trends Neurosci 24:726-31. 2001
..The posterior lateral hypothalamus contains orexin/hypocretin neurons that are crucial for maintaining normal wakefulness. A model is proposed in which wake- and sleep-promoting neurons inhibit each other, which results in stable ..
- Afferents to the orexin neurons of the rat brain
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
J Comp Neurol 494:845-61. 2006
Emotions, stress, hunger, and circadian rhythms all promote wakefulness and behavioral arousal...
- Local sleep in awake rats
Vladyslav V Vyazovskiy
Department of Psychiatry, University of Wisconsin Madison, Madison, 6001 Research Park Boulevard, Wisconsin 53719, USA
Nature 472:443-7. 2011
..Thus, although both the EEG and behaviour indicate wakefulness, local populations of neurons in the cortex may be falling asleep, with negative consequences for performance.
- Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine
Zhi Li Huang
Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka 565 0874, Japan
Nat Neurosci 8:858-9. 2005
Caffeine, a component of tea, coffee and cola, induces wakefulness. It binds to adenosine A1 and A2A receptors as an antagonist, but the receptor subtype mediating caffeine-induced wakefulness remains unclear...
- The cortisol awakening response (CAR): facts and future directions
Technische Universitat Dresden, Faculty of Science, Department of Psychology, Dresden, Germany
Int J Psychophysiol 72:67-73. 2009
..The present paper reviews the current knowledge on the neural regulation of the CAR and factors influencing this phenomenon and considerations are addressed concerning the exact function of the CAR...
- Two dopaminergic neurons signal to the dorsal fan-shaped body to promote wakefulness in Drosophila
Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
Curr Biol 22:2114-23. 2012
..Although dopamine (DA) is thought to play a key role in sleep/wake regulation, the identities of the individual DA neurons and their downstream targets required for this process are unknown...
- Altered sleep-wake characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice
Zhi Li Huang
Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
Proc Natl Acad Sci U S A 103:4687-92. 2006
..Blockade of the histamine H(3) receptor (H(3)R) is proposed to induce wakefulness by regulating the release of various wake-related transmitters, not only histamine...
- Unresponsive wakefulness syndrome: a new name for the vegetative state or apallic syndrome
Dept of Neurology, Cyclotron Research Centre, University Hospital and University of Liège, Belgium
BMC Med 8:68. 2010
..This syndrome has been coined vegetative state. We here present a new name for this challenging neurological condition: unresponsive wakefulness syndrome (abbreviated UWS).
- Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep-wake cycle
Oum Kaltoum Hassani
Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada H3A 2B4
Proc Natl Acad Sci U S A 106:2418-22. 2009
..Orx or hypocretin) in the lateral hypothalamus, a peptide and region known to be critical for maintaining wakefulness. Evidence from knockout and c-Fos studies suggests, however, that the MCH neurons might play a different role ..
- Wakefulness affects synaptic and network activity by increasing extracellular astrocyte-derived adenosine
L Ian Schmitt
Department of Neuroscience, Tufts University Medical School, Boston, MA 02111, USA
J Neurosci 32:4417-25. 2012
..studies have not determined whether the concentration of this signaling molecule increases in response to wakefulness. Here, we show that the level of adorA1R activation increases in response to wakefulness in mice (Mus musculus)...
- Separating the contribution of glucocorticoids and wakefulness to the molecular and electrophysiological correlates of sleep homeostasis
Center for Integrative Genomics, University of Lausanne, CH 1015 Lausanne, Switzerland
Sleep 33:1147-57. 2010
..Because sleep deprivation also induces stress, we here determined the contribution of the corticosterone component of the stress response to the electrophysiological and molecular markers of sleep need in mice...
- Differential effects of controllable and uncontrollable footshock stress on sleep in mice
Larry D Sanford
Sleep Research Laboratory, Department of Pathology and Anatomy, Eastern Virginia Medical School, P O Box 1980, Norfolk, VA 23501, USA
Sleep 33:621-30. 2010
..We compared sleep in animals trained with IS to that in animals trained with escapable shock (ES), a controllable stressor, in a paradigm in which animals always received shock but could terminate it by their actions...
- Induction of hippocampal long-term potentiation during waking leads to increased extrahippocampal zif-268 expression during ensuing rapid-eye-movement sleep
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 22:10914-23. 2002
- Widespread changes in synaptic markers as a function of sleep and wakefulness in Drosophila
Giorgio F Gilestro
Department of Psychiatry, University of Wisconsin, Madison, WI 53719, USA
Science 324:109-12. 2009
..However, little is known about how wakefulness and sleep affect synapses...
- Fos expression in orexin neurons varies with behavioral state
I V Estabrooke
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
J Neurosci 21:1656-62. 2001
..Lack of orexin produces narcolepsy, which is characterized by poor maintenance of wakefulness and intrusions of rapid eye movement (REM) sleep or REM sleep-like phenomena into wakefulness...
- A video method to study Drosophila sleep
John E Zimmerman
Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, 125 South 31st St, Suite 2100, Philadelphia, PA 19104 3403, USA
Sleep 31:1587-98. 2008
..To use video to determine the accuracy of the infrared beam-splitting method for measuring sleep in Drosophila and to determine the effect of time of day, sex, genotype, and age on sleep measurements...
- Sleep after learning aids memory recall
Department of Neuroendocrinology, University of Lubeck, 23538 Lubeck, Germany
Learn Mem 13:259-62. 2006
..Sleep deprivation has a detrimental effect on memory, which was significant after a night of recovery sleep. Thus, fatigue accumulating during wake intervals could be ruled out as a confound...
- High sensitivity of human melatonin, alertness, thermoregulation, and heart rate to short wavelength light
Centre for Chronobiology, Psychiatric University Clinic, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
J Clin Endocrinol Metab 90:1311-6. 2005
- Extensive and divergent effects of sleep and wakefulness on brain gene expression
Department of Psychiatry, University of Wisconsin, Madison, 53719, USA
Neuron 41:35-43. 2004
..change their expression between day and night and demonstrate that half of them are modulated by sleep and wakefulness independent of time of day...
- Sleep homeostasis in Drosophila melanogaster
Department of Psychiatry, University of Wisconsin, Madison 53719, USA
Sleep 27:628-39. 2004
..A central feature of mammalian sleep is its homeostatic regulation by the amount of previous wakefulness. Dissecting the mechanisms of homeostatic regulation is likely to provide key insights into the functions of ..
- Effects and mechanisms of wakefulness on local cortical networks
Christine M Constantinople
Department of Neuroscience and the Kavli Institute for Brain Science, Columbia University, New York, NY 10032, USA
Neuron 69:1061-8. 2011
..impacts cortical circuitry, we recorded intracellularly from the same neurons, under anesthesia and subsequent wakefulness, in rat barrel cortex...
- Adenosine, energy metabolism and sleep homeostasis
Institute of Biomedicine, University of Helsinki, PO Box 63, 00014 University of Helsinki, Helsinki, Finland
Sleep Med Rev 15:123-35. 2011
..appears to be central in the regulation/execution of recovery sleep after sleep deprivation (SD), or prolonged wakefulness. Adenosine concentration increases in this area during SD, and this increase induces sleep while prevention of ..
- Precise olfactory responses tile the sniff cycle
Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, USA
Nat Neurosci 14:1039-44. 2011
..The temporal specificity of mitral/tufted cell output provides a potentially rich source of information for downstream olfactory areas...
- Sleep selectively enhances memory expected to be of future relevance
Department of Neuroendocrinology, University of Lubeck, 23538 Lubeck, Germany
J Neurosci 31:1563-9. 2011
..Human subjects learned declarative memories (word paired associates) before retention periods of sleep or wakefulness. Postlearning sleep compared with wakefulness produced a strong improvement at delayed retrieval only if the ..
- The homeostatic regulation of sleep need is under genetic control
Biochemistry and Neurophysiology Unit, Department of Psychiatry, University of Geneva, Chene Bourg, Switzerland
J Neurosci 21:2610-21. 2001
..in the 1-4 Hz range, in slow-wave sleep (SWS) is in a quantitative and predictive relationship with prior wakefulness. Thus, sleep loss evokes a proportional increase in delta power, and excess sleep a decrease...
- Sleep enhances plasticity in the developing visual cortex
M G Frank
W. M. Keck Foundation Center, for Integrative Neuroscience, Department of Physiology, University of California, San Francisco, San Francisco, CA 94143-0444, USA
Neuron 30:275-87. 2001
..sleep enhanced the effects of a preceding period of monocular deprivation on visual cortical responses, but wakefulness in complete darkness did not do so...
- From waking to sleeping: neuronal and chemical substrates
Barbara E Jones
Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal, Quebec H3A 2B4, Canada
Trends Pharmacol Sci 26:578-86. 2005
..Selective enhancement and attenuation of their discharge, transmitter release and postsynaptic actions comprise the substrates for the major stimulant and hypnotic drugs...
- The official World Association of Sleep Medicine (WASM) standards for recording and scoring periodic leg movements in sleep (PLMS) and wakefulness (PLMW) developed in collaboration with a task force from the International Restless Legs Syndrome Study Grou
Sleep Disorders Center, San Raffaele Hospital, Milano, Italy
Sleep Med 7:175-83. 2006
- The histaminergic system regulates wakefulness and orexin/hypocretin neuron development via histamine receptor H1 in zebrafish
Neuroscience Center and Institute of Biomedicine, Anatomy, Faculty of Medicine, P O B 63, 00014 University of Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland
FASEB J 25:4338-47. 2011
The histaminergic and hypocretin/orexin (hcrt) neurotransmitter systems play crucial roles in alertness/wakefulness in rodents...
- Are spatial memories strengthened in the human hippocampus during slow wave sleep?
Cyclotron Research Center, University of Liege, B 4000 Liege, Belgium
Neuron 44:535-45. 2004
- Why we sleep: the temporal organization of recovery
Howard Hughes Medical Institute and Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, United States of America
PLoS Biol 6:e106. 2008
- Noradrenergic modulation of wakefulness/arousal
Craig W Berridge
Psychology Department, University of Wisconsin, Madison, WI 53706, USA
Sleep Med Rev 16:187-97. 2012
- Neuropeptide S promotes wakefulness through activation of the posterior hypothalamic histaminergic and orexinergic neurons
Department of Neuroscience, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, 199 Donggang Xi Road, Lanzhou 730000, PR China
Neuroscience 207:218-26. 2012
..NPS at 0.1 and 1 nmol increased significantly wakefulness (W) during the first 2 h (54.7 ± 3.2 and 64.9 ± 2.1 min, respectively, vs. 41.4 ± 2...
- Dopaminergic role in stimulant-induced wakefulness
J P Wisor
Sleep Disorders Research Center, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
J Neurosci 21:1787-94. 2001
..mice, deletion of the dopamine transporter (DAT) gene reduced non-rapid eye movement sleep time and increased wakefulness consolidation independently from locomotor effects...
- Sleep preferentially enhances memory for emotional components of scenes
Jessica D Payne
Department of Psychology, Harvard University, Cambridge, MA 02138, USA
Psychol Sci 19:781-8. 2008
..Memory for a negative scene develops differentially across time delays containing sleep and wake, with sleep selectively consolidating those aspects of memory that are of greatest value to the organism...
- EEG microstates of wakefulness and NREM sleep
Brain Imaging Center, Department of Neurology, University of Frankfurt, A M, Germany
Neuroimage 62:2129-39. 2012
..the question whether EEG-microstate features are altered in different stages of NREM sleep compared to wakefulness. 32-channel EEG of 32 subjects in relaxed wakefulness and NREM sleep was analyzed using a clustering algorithm, ..
- Age-related changes in the circadian and homeostatic regulation of human sleep
Centre for Chronobiology, Psychiatric University Clinics, Basel, Switzerland
Chronobiol Int 23:461-74. 2006
..we favor the hypothesis that age-related changes in sleep are due to weaker circadian regulation of sleep and wakefulness. Our data suggest that manipulations of the circadian timing system, rather than the sleep homeostat, may offer ..
- The process of awakening: a PET study of regional brain activity patterns mediating the re-establishment of alertness and consciousness
Thomas J Balkin
Department of Behavioral Biology, Walter Reed Army Institute of Research, Washington, DC 20307 5100, USA
Brain 125:2308-19. 2002
..Across the ensuing 15 min of wakefulness, further increases in CBF were evident primarily in anterior cortical regions, suggesting that the dissipation ..
- Mapping resting-state brain networks in conscious animals
Center for Comparative NeuroImaging CCNI, Department of Psychiatry, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, United States
J Neurosci Methods 189:186-96. 2010
- Experience-dependent changes in cerebral activation during human REM sleep
Cyclotron Research Centre, University of Liege, Belgium
Nat Neurosci 3:831-6. 2000
..Several brain areas activated during the execution of a serial reaction time task during wakefulness were significantly more active during REM sleep in subjects previously trained on the task than in non-trained ..
- Arousal effect of orexin A depends on activation of the histaminergic system
Z L Huang
Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Japan
Proc Natl Acad Sci U S A 98:9965-70. 2001
..Here we provide several lines of evidence that orexin A induces wakefulness by means of the TMN and histamine H(1) receptor (H1R)...
- Automatic sleep/wake identification from wrist activity
R J Cole
Department of Psychiatry, University of California, San Diego
Sleep 15:461-9. 1992
The purpose of this study was to develop and validate automatic scoring methods to distinguish sleep from wakefulness based on wrist activity...
- Circadian temperature and melatonin rhythms, sleep, and neurobehavioral function in humans living on a 20-h day
J K Wyatt
Circadian, Neuroendocrine and Sleep Disorders Section, Division of Endocrinology, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Physiol 277:R1152-63. 1999
..This wake-dependent deterioration of neurobehavioral functions can be offset by the circadian drive for wakefulness, which peaks in the latter half of the habitual waking day during entrainment...
- Functional imaging of working memory after 24 hr of total sleep deprivation
Michael W L Chee
Cognitive Neuroscience Laboratory, SingHealth Research Laboratories, Singapore 169611, Singapore
J Neurosci 24:4560-7. 2004
..Our findings provide neural correlates to explain why task performance in relatively more complex tasks is better preserved relative to simpler ones after SD...
- Sustained attention performance during sleep deprivation: evidence of state instability
S M Doran
Division of Sleep and Chronobiology, Department of Psychiatry, Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, 1013 Blockley Hall, 423 Guardian Drive, Philadelphia, Pennsylvania 19104, USA
Arch Ital Biol 139:253-67. 2001
..subjects also had increasingly greater performance variability as a function of time on task after 18 hours of wakefulness. During sleep deprivation, variability in PVT performance reflected a combination of normal timely responses, ..
- Localized and lateralized cerebral glucose metabolism associated with eye movements during REM sleep and wakefulness: a positron emission tomography (PET) study
C C Hong
Department of Psychiatry, University of California, San Diego, La Jolla 92093-0603, USA
Sleep 18:570-80. 1995
..Our results show that the same cortical areas are involved in eye movements in both REM sleep and wakefulness and suggest that REM sleep eye movements are saccadic scans of targets in the dream scene...
- To eat or to sleep? Orexin in the regulation of feeding and wakefulness
J T Willie
Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, 75390 9050, USA
Annu Rev Neurosci 24:429-58. 2001
..throughout the central nervous system (CNS) to nuclei known to be important in the control of feeding, sleep-wakefulness, neuroendocrine homeostasis, and autonomic regulation...
- Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice
Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Japan
PLoS ONE 6:e20360. 2011
Hypothalamic neurons expressing neuropeptide orexins are critically involved in the control of sleep and wakefulness. Although the activity of orexin neurons is thought to be influenced by various neuronal input as well as humoral ..
- Mammalian circadian biology: elucidating genome-wide levels of temporal organization
Phillip L Lowrey
Howard Hughes Medical Institute, Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
Annu Rev Genomics Hum Genet 5:407-41. 2004
- insomniac and Cullin-3 regulate sleep and wakefulness in Drosophila
Laboratory of Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
Neuron 72:964-76. 2011
..The extensive evolutionary conservation of insomniac and Cul3 suggests that protein degradation pathways may have a general role in governing the sleep and wakefulness of animals.
- Cholinergic basal forebrain neurons burst with theta during waking and paradoxical sleep
Maan Gee Lee
Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
J Neurosci 25:4365-9. 2005
..Through their maximal firing and rhythmic theta discharge during active waking and paradoxical sleep, the cholinergic neurons can thus modulate the cortex to promote activation along with plasticity during these two states...
- Internal brain state regulates membrane potential synchrony in barrel cortex of behaving mice
James F A Poulet
Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
Nature 454:881-5. 2008
..somatosensory barrel cortex in behaving mice, that the V(m) of nearby neurons is highly correlated during quiet wakefulness. However, when the mouse is whisking, an internally generated state change reduces the V(m) correlation, ..
- Lasting syndrome of depression produced by reduction in serotonin uptake during postnatal development: evidence from sleep, stress, and behavior
Universite Pierre et Marie Curie Paris 6, Unité Mixte de Recherche S677, F 75013 Paris, France
J Neurosci 28:3546-54. 2008
..the impact of early-life, transient versus genetic, permanent alterations of serotonin reuptake on sleep-wakefulness patterns, depression-related behavior, and associated physiological features...
- Large ventral lateral neurons modulate arousal and sleep in Drosophila
Department of Physiology and Biophysics, University of California, Irvine, California 92697, USA
Curr Biol 18:1537-45. 2008
..exhibit higher daytime-light-driven spontaneous action-potential firing rates in Drosophila, coinciding with wakefulness and locomotor-activity behavior...
- Selective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture
Yanagisawa Orphan Receptor Project, ERATO, Japan Science and Technology Agency, Saitama 322 0012 Japan
Proc Natl Acad Sci U S A 106:4459-64. 2009
..Thus, GABA(B) receptors on orexin neurons are crucial in the appropriate control of the orexinergic tone through sleep/wake states, thereby stabilizing the state switching mechanisms...
- A mathematical model of the sleep/wake cycle
Michael J Rempe
Mathematical Biosciences Institute, Ohio State University, Columbus, OH 43210, USA
J Math Biol 60:615-44. 2010
..These features include the timing of sleep and wakefulness under normal and sleep-deprived conditions, ultradian rhythms, more frequent switching between sleep and ..
- Stress response genes protect against lethal effects of sleep deprivation in Drosophila
Paul J Shaw
The Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, California 92121, USA
Nature 417:287-91. 2002
..These data represent the first step in identifying the molecular mechanisms that constitute the sleep homeostat...
- Identification of a neural circuit that underlies the effects of octopamine on sleep:wake behavior
Department of Neuroscience, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
Neuron 65:670-81. 2010
..These studies define the cellular and molecular basis of octopamine action and suggest that the PI is a sleep:wake-regulating neuroendocrine structure like the mammalian hypothalamus...
- Reverse replay of behavioural sequences in hippocampal place cells during the awake state
David J Foster
Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 46 5223, Cambridge, Massachusetts 02139, USA
Nature 440:680-3. 2006
..This replay is suggestive of a role in the evaluation of event sequences in the manner of reinforcement learning models. We propose that such replay might constitute a general mechanism of learning and memory...
- Sleep facilitates consolidation of emotional declarative memory
Sleep and Neuroimaging Laboratory, Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
Psychol Sci 17:891-8. 2006
..These findings hold important implications for understanding of human memory processing, suggesting that the facilitation of memory for emotionally salient information may preferentially develop during sleep...
- Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice
Department of Molecular Genetics and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 9050, USA
Proc Natl Acad Sci U S A 101:4649-54. 2004
Narcolepsy-cataplexy is a neurological disorder associated with the inability to maintain wakefulness and abnormal intrusions of rapid eye movement sleep-related phenomena into wakefulness such as cataplexy...
- Global forebrain dynamics predict rat behavioral states and their transitions
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 24:11137-47. 2004
- Differential expression of plasticity-related genes in waking and sleep and their regulation by the noradrenergic system
The Neurosciences Institute, San Diego, California 92121, USA
J Neurosci 20:9187-94. 2000
..These molecular results complement behavioral evidence and provide a mechanism for the impairment of long-term memory acquisition during sleep...
- Exploratory behavior, cortical BDNF expression, and sleep homeostasis
Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
Sleep 30:129-39. 2007
..eye movement (NREM) sleep is a reliable indicator of sleep need, as it increases with the duration of prior wakefulness and decreases during sleep...
- Sleep-dependent motor memory plasticity in the human brain
M P Walker
Sleep and Neuroimaging Laboratory, FD Feldberg 862, Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
Neuroscience 133:911-7. 2005
..This evidence of an overnight, systems-level change in the representation of a motor memory holds important implications for acquiring real-life skills and in clinical rehabilitation following brain trauma, such as stroke...
- Functional magnetic resonance imaging-assessed brain responses during an executive task depend on interaction of sleep homeostasis, circadian phase, and PER3 genotype
Cyclotron Research Centre, University of Liege, B 4000 Liege, Belgium
J Neurosci 29:7948-56. 2009
..The findings support a model of individual differences in executive control, in which the allocation of prefrontal resources is constrained by sleep pressure and circadian phase...
- Aging and nocturnal driving: better with coffee or a nap? A randomized study
Clinique du Sommeil, CHU Pellegrin, Bordeaux, France
Sleep 30:1808-13. 2007
..To test the effects of coffee and napping on nocturnal driving in young and middle-aged participants...
- The cortisol awakening response: more than a measure of HPA axis function
Psychophysiology and Stress Research Group, Department of Psychology, University of Westminster, London, UK
Neurosci Biobehav Rev 35:97-103. 2010
..An association between the CAR and the ending of sleep inertia is discussed...
- Mathematical model of network dynamics governing mouse sleep-wake behavior
Cecilia G Diniz Behn
Department of Mathematics and Center for BioDynamics, Boston University, MA, USA
J Neurophysiol 97:3828-40. 2007
..between brief and sustained wake bouts, the model suggests distinct network mechanisms for the two types of wakefulness. Because circadian and other factors alter the fine architecture of sleep-wake behavior, this model provides a ..
- Orexin/hypocretin and histamine: distinct roles in the control of wakefulness demonstrated using knock-out mouse models
INSERM U628, Integrated Physiology of Brain Arousal Systems, IFR19, 69373 Lyon, France
J Neurosci 29:14423-38. 2009
To determine the respective role played by orexin/hypocretin and histamine (HA) neurons in maintaining wakefulness (W), we characterized the behavioral and sleep-wake phenotypes of orexin (Ox) knock-out (-/-) mice and compared them with ..
- State-specific effects of sevoflurane anesthesia on sleep homeostasis: selective recovery of slow wave but not rapid eye movement sleep
Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan 48109 5048, USA
Anesthesiology 114:302-10. 2011
..In the current study, the effects of sevoflurane on recovery from total sleep deprivation were investigated...
- Heart-rate variability in women during 40-hour prolonged wakefulness
Thermophysiological Chronobiology, Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland
Chronobiol Int 27:1609-28. 2010
Heart-rate variability patterns of 18 women during a 40-h constant routine of prolonged wakefulness under controlled laboratory conditions were analyzed...
- Analysis of the QTL for sleep homeostasis in mice: Homer1a is a likely candidate
Department of Medicine, Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Translational Research Laboratories, Philadelphia, PA 19104 3403, USA
Physiol Genomics 33:91-9. 2008
..We established the expression pattern of selected genes located in the Dps1 interval in sleep and wakefulness in B6 and D2 parental strains...