Genomes and Genes
Summary: Physiologic mechanisms which regulate or control the appetite and food intake.
Publications253 found, 100 shown here
- Central leptin gene therapy ameliorates diabetes type 1 and 2 through two independent hypothalamic relays; a benefit beyond weight and appetite regulationSatya P Kalra
Department of Neuroscience, McKnight Brain Institute, College of Medicine, University of Florida, PO Box 100244, Gainesville, FL 32610 0244, United States
Peptides 30:1957-63. 2009....
- Anatomy and regulation of the central melanocortin systemRoger D Cone
Vollum Institute and the Center for the Study of Weight Regulation, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
Nat Neurosci 8:571-8. 2005....
- Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypassCarel W le Roux
Department of Metabolic Medicine, Hammersmith Hospital, Imperial College, London, United Kingdom
Ann Surg 246:780-5. 2007..To evaluate the physiologic importance of the satiety gut hormones...
- The timing of "catch-up growth" affects metabolism and appetite regulation in male rats born with intrauterine growth restrictionBérengère Coupé
Institut National de la Recherche Agronomique, UMR 1280 Physiologie des Adaptations Nutritionnelles, Universite de Nantes, Nantes, France
Am J Physiol Regul Integr Comp Physiol 297:R813-24. 2009..Additionally, catch-up growth immediately after early malnutrition could be a key point for the programming of postprandial hyperleptinemia...
- Ghrelin modulates brain activity in areas that control appetitive behaviorSaima Malik
Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada
Cell Metab 7:400-9. 2008..This demonstrates that metabolic signals such as ghrelin may favor food consumption by enhancing the hedonic and incentive responses to food-related cues...
- The role of gut hormones and the hypothalamus in appetite regulationKeisuke Suzuki
Section of Investigative Medicine, Imperial College London, London, UK
Endocr J 57:359-72. 2010..is a crucial region for integrating signals from central and peripheral pathways and plays a major role in appetite regulation. In addition, there are reciprocal connections with the brainstem and higher cortical centres...
- Cerebral processing of food-related stimuli: effects of fasting and genderRudolf Uher
King s College London, Institute of Psychiatry PO59, DeCrespigny Park, London SE5 8AF, UK
Behav Brain Res 169:111-9. 2006..The stronger reactivity to external food-related stimuli in women may be explored as a marker of gender-related susceptibility to eating disorders...
- Critical role for peptide YY in protein-mediated satiation and body-weight regulationRachel L Batterham
Centre for Diabetes and Endocrinology, Department of Medicine, University College London, WC1E 6JJ, United Kingdom
Cell Metab 4:223-33. 2006..Our findings suggest that modulating the release of endogenous satiety factors, such as PYY, through alteration of specific diet constituents could provide a rational therapy for obesity...
- Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in ratsPatrice D Cani
Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Department of Pharmaceutical Sciences, Universite Catholique de Louvain, B 1200 Brussels, Belgium
Br J Nutr 92:521-6. 2004....
- Oxyntomodulin inhibits food intake in the ratC L Dakin
Endocrine Unit, Department of Metabolic Medicine, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom W12 0NN
Endocrinology 142:4244-50. 2001..2 nM; glucagon-like peptide-1, 0.16 nM). One explanation for this is that there might be an oxyntomodulin receptor to which exendin-(9-39) can also bind and act as an antagonist...
- Centrally administered urocortin 3 inhibits food intake and gastric emptying in miceMiharu Ushikai
Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
Endocrine 39:113-7. 2011..These results indicated that Ucn3 influences feeding behavior and gut motility, and may be a promising therapeutic target in the treatment of eating and functional gastrointestinal disorders...
- Mechanisms underlying the association between breastfeeding and obesityCynthia J Bartok
Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802, USA
Int J Pediatr Obes 4:196-204. 2009..These three protective effects may promote slower growth and lower body fat levels in breastfed infants, which reduce risk of overweight and obesity later in life...
- The addition of a protein-rich breakfast and its effects on acute appetite control and food intake in 'breakfast-skipping' adolescentsH J Leidy
Department of Dietetics and Nutrition, University of Kansas Medical Center KUMC, Kansas City, KS 66160, USA
Int J Obes (Lond) 34:1125-33. 2010..It is unclear whether the addition of breakfast, with emphasis on dietary protein, leads to better appetite and energy intake regulation in adolescents...
- Hypothalamic-brainstem circuits controlling eatingJames E Blevins
Research and Development Service, Department of Veterans Affairs Puget Sound Health Care System, and Department of Medicine, Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, Wash, USA
Forum Nutr 63:133-40. 2010..The present article describes the state of our knowledge about specific neural circuits between the hypothalamus and brainstem that play a role in the interaction of leptin and meal-control signals to control food intake...
- Metabolic and hedonic drives in the neural control of appetite: who is the boss?Hans Rudolf Berthoud
Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
Curr Opin Neurobiol 21:888-96. 2011....
- The effects of exercise-induced weight loss on appetite-related peptides and motivation to eatC Martins
Obesity Research Group, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, 7489 Trondheim, Norway
J Clin Endocrinol Metab 95:1609-16. 2010..An increase in energy intake is likely to result from changes in the appetite control system toward an orexigenic environment; however, few studies have measured how exercise impacts on both orexigenic and anorexigenic peptides...
- Hypothalamic dopamine and serotonin in the regulation of food intakeM M Meguid
Neuroscience Program, Surgical Metabolism and Nutrition Laboratory, Department of Surgery, University Hospital, SUNY Upstate Medical University, Syracuse, New York 13210, USA
Nutrition 16:843-57. 2000..Data concerning the role of sex-related hormones on dopamine and serotonin with regard to the LHA and VMN in relation to the modulation of food intake are also presented...
- Appetite controlKatie Wynne
Endocrine Unit, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
J Endocrinol 184:291-318. 2005..It also considers future therapeutic targets for the treatment of obesity...
- Do infants fed from bottles lack self-regulation of milk intake compared with directly breastfed infants?Ruowei Li
Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Division of Nutrition, Physical Activity, and Obesity, 4770 Buford Highway, MS K25, Atlanta, GA 30341, USA
Pediatrics 125:e1386-93. 2010..We studied whether infants' self-regulation of milk intake is affected by feeding mode (bottle versus breast) and the type of milk in the bottle (formula versus expressed breast milk)...
- Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuliMichael Rosenbaum
Department of Pediatrics, Division of Molecular Genetics, Naomi Berrie Diabetes Center, Columbia University Medical Center New York Presbyterian Medical Center, New York, New York, USA
J Clin Invest 118:2583-91. 2008..These data are consistent with a model of the weight-reduced state as one of relative leptin deficiency...
- The right brain hypothesis for obesityMiguel Alonso-Alonso
Berenson Allen Center for Noninvasive Brain Stimulation, Behavioral Neurology Unit, Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass 02215, USA
JAMA 297:1819-22. 2007
- Activation in brain energy regulation and reward centers by food cues varies with choice of visual stimulusE A Schur
Division of General Internal Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98104, USA
Int J Obes (Lond) 33:653-61. 2009To develop a non-invasive method of studying brain mechanisms involved in energy homeostasis and appetite regulation in humans by using visual food cues that are relevant to individuals attempting weight loss.
- Injection of Urocortin 3 into the ventromedial hypothalamus modulates feeding, blood glucose levels, and hypothalamic POMC gene expression but not the HPA axisPeilin Chen
Department of Medicine and Cell Biology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Am J Physiol Endocrinol Metab 298:E337-45. 2010..In conclusion, the present study demonstrates that CRFR2 in the VMH mediates some of the central effects of Ucn 3, and the ARH melanocortin system may be a downstream target of VMH CRFR2 neurons...
- How palatable food disrupts appetite regulationCharlotte Erlanson-Albertsson
Section of Endocrinology and Metabolism, Department of Experimental Medicine, University of Lund, Lund, Sweden
Basic Clin Pharmacol Toxicol 97:61-73. 2005b>Appetite regulation is part of a feedback system that controls the energy balance, involving a complex interplay of hunger and satiety signals, produced in the hypothalamus as well as in peripheral organs...
- Free fatty acid receptor 2 and nutrient sensing: a proposed role for fibre, fermentable carbohydrates and short-chain fatty acids in appetite regulationMichelle L Sleeth
Department of Investigative Medicine, Imperial College London, London, UK
Nutr Res Rev 23:135-45. 2010....
- Appetite regulation and energy balanceCharlotte Erlanson-Albertsson
Department of Experimental Medicine, University of Lund, Lund, Sweden
Acta Paediatr Suppl 94:40-1. 2005..The palatable food works by weakening the satiety signals and activating the hunger signals. The reward system with endogenous opiates may also be activated...
- Melanocortin activation of nucleus of the solitary tract avoids anorectic tachyphylaxis and induces prolonged weight lossGang Li
Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida 32610, USA
Am J Physiol Endocrinol Metab 293:E252-8. 2007....
- Expanding role of AMPK in endocrinologyBlerina Kola
Department of Endocrinology, Barts and The London, Queen Mary s School of Medicine and Dentistry, University of London, London, EC1M 6BQ, UK
Trends Endocrinol Metab 17:205-15. 2006..Recent studies have illustrated the interaction between hormones and AMPK, and highlighted AMPK as a potential target for the development of tissue-specific AMPK modulators in the treatment of obesity and the metabolic syndrome...
- Changes in gastrointestinal hormones and leptin after Roux-en-Y gastric bypass procedure: a reviewLauren M Beckman
Department of Food Science and Nutrition, University of Minnesota, 225 Food Science and Nutrition, University of Minnesota, 1334 Eckles Ave, St Paul, MN 55108 6099, USA
J Am Diet Assoc 110:571-84. 2010..A review of the literature also highlighted some research gaps that should be taken into consideration when designing future studies...
- Critical role of STAT3 in leptin's metabolic actionsChristoph Buettner
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Cell Metab 4:49-60. 2006..Our results demonstrate that the activation of the hypothalamic STAT3 pathway is an absolute requirement for the effects of leptin on food intake and hepatic glucose metabolism...
- Leptin-regulated endocannabinoids are involved in maintaining food intakeV Di Marzo
Endocannabinoid Research Group, Istituto per la Chimica di Molecole di Interesse Biologico, CNR, 80072, Arco Felice, Naples, Italy
Nature 410:822-5. 2001..These findings indicate that endocannabinoids in the hypothalamus may tonically activate CB1 receptors to maintain food intake and form part of the neural circuitry regulated by leptin...
- Hypothalamic regulation of food intake and clinical therapeutic applicationsKatherine Anne Simpson
Department of Investigative Medicine, Imperial College, London United Kingdom
Arq Bras Endocrinol Metabol 53:120-8. 2009..In addition there are many projections to and from the brainstem, cortical areas and reward pathways, which modulate food intake...
- Do SCFA have a role in appetite regulation?Julia Darzi
University of Surrey, Guildford, Surrey, UK
Proc Nutr Soc 70:119-28. 2011..We therefore postulate SCFA may have a role in appetite regulation and energy homeostasis...
- Episodic memory and appetite regulation in humansJeffrey M Brunstrom
Nutrition and Behaviour Unit, School of Experimental Psychology, University of Bristol, Bristol, United Kingdom
PLoS ONE 7:e50707. 2012..For the first time, this manipulation exposes the independent and important contribution of memory processes to satiety. Opportunities exist to capitalise on this finding to reduce energy intake in humans...
- A putative physiological role of hypothalamic CNTF in the control of energy homeostasisC M Vacher
Laboratoire de Neuroendocrinologie Moléculaire de la Prise Alimentaire, UMR 1197 INRA, Université Paris 11, Bâtiment 447, 91405 Orsay, France
FEBS Lett 582:3832-8. 2008..Thus endogenous CNTF may act, in some individuals, as a protective factor against weight gain during hypercaloric diet and could account for individual differences in the susceptibility to obesity...
- Brain imaging studies of appetite in the context of obesity and the menstrual cycleDean A Van Vugt
Departments of Obstetrics and Gynaecology and Physiology, Queen s University, Kingston, Ontario, Canada
Hum Reprod Update 16:276-92. 2010..Menstrual cycle dependent changes in brain responses to food cues may provide insight into the normal physiological control of ingestive behavior as well as dysfunctional regulation associated with disordered eating...
- Insulin and hippocampus activation in response to images of high-calorie food in normal weight and obese adolescentsSandra Wallner-Liebmann
Institute of Pathophysiology and Immunology, Center for Molecular Medicine, Medical University of Graz, Graz, Austria
Obesity (Silver Spring) 18:1552-7. 2010..Interestingly, only the waist circumference, as a main indicator of abdominal obesity, correlated significantly with the hippocampal activation patterns, and not the BMI...
- Do infants fed directly from the breast have improved appetite regulation and slower growth during early childhood compared with infants fed from a bottle?Katherine I Disantis
University of Pennsylvania, Perelman School of Medicine, Center for Clinical Epidemiology and Biostatistics, Philadelphia, PA, USA
Int J Behav Nutr Phys Act 8:89. 2011..of this study was to evaluate the hypothesis that feeding human milk from the breast (direct breastfeeding) has a more optimal association with subsequent child appetite regulation behaviors and growth, when compared to bottle-feeding.
- Imaging appetite-regulating pathways in the central nervous system using manganese-enhanced magnetic resonance imagingJames R C Parkinson
Department of Metabolic Medicine, Imperial College London, Hammersmith Hospital, London, UK
Neuroendocrinology 89:121-30. 2009..Insight into the mechanisms which govern appetite regulation is central to understanding the pathophysiology of obesity and the design of effective therapeutic ..
- Brain regulation of appetite and satietyRexford S Ahima
Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, PA 19104, USA
Endocrinol Metab Clin North Am 37:811-23. 2008..The pathogenesis and treatment of obesity and abnormalities of glucose and lipid metabolism are discussed...
- Effects of cereal breakfasts on postprandial glucose, appetite regulation and voluntary energy intake at a subsequent standardized lunch; focusing on rye productsLiza Ah Rosén
Department of Food Technology, Engineering and Nutrition, Lund University, Sweden
Nutr J 10:7. 2011..The objective of the present paper was to evaluate the mechanism for a reduced postprandial insulin demand with rye products, and to explore possible appetite regulating properties...
- The influence of higher protein intake and greater eating frequency on appetite control in overweight and obese menHeather J Leidy
Department of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, Kansas, USA
Obesity (Silver Spring) 18:1725-32. 2010..Collectively, these data suggest that higher protein intake promotes satiety and challenge the concept that increasing the number of eating occasions enhances satiety in overweight and obese men...
- PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humansRachel L Batterham
Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK
Nature 450:106-9. 2007..An increased understanding of how such homeostatic and higher brain functions are integrated may pave the way for the development of new treatment strategies for obesity...
- AMP-activated protein kinase plays a role in the control of food intakeUlrika Andersson
Medical Research Council Clinical Sciences Centre, Cellular Stress Group and Endocrine Unit, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 ONN, United Kingdom
J Biol Chem 279:12005-8. 2004..These findings demonstrate that AMPK plays a role in the regulation of feeding and identify AMPK as a novel target for anti-obesity drugs...
- Insulin acts at different CNS sites to decrease acute sucrose intake and sucrose self-administration in ratsDianne P Figlewicz
Metabolism Endocrinology, 151 VA Puget Sound Health Care System, 1660 So Columbian Way, Seattle WA 98108, USA
Am J Physiol Regul Integr Comp Physiol 295:R388-94. 2008..Further, they support the interpretation that adiposity signals, such as insulin, can decrease different aspects of ingestion of a palatable food, such as sucrose, in an anatomically specific manner...
- Gastrointestinal hormones regulating appetiteOwais Chaudhri
Department of Metabolic Medicine, Imperial College Faculty of Medicine, Hammersmith Hospital, London, UK
Philos Trans R Soc Lond B Biol Sci 361:1187-209. 2006..b>Appetite regulation offers an integrated model of a brain-gut axis comprising both endocrine and neurological systems...
- Endocannabinoids and food intake: newborn suckling and appetite regulation in adulthoodEster Fride
Department of Behavioral Sciences, College of Judea and Samaria, Ariel, Israel
Exp Biol Med (Maywood) 230:225-34. 2005..Furthermore, the role of cannabinoid CB1 receptor activation for milk suckling in newborns may open new doors toward understanding nonorganic failure-to-thrive in infants, who display growth failure without known organic cause...
- Protein, amino acids and the control of food intakeDaniel Tome
Unité INRA 914 Physiologie de la Nutrition et du Comportement Alimentaire, Institut National Agronomique Paris Grignon, 16, rue Claude Bernard, 75231 Paris Cedex 05, France
Br J Nutr 92:S27-30. 2004..It is likely that the system responds precisely when protein and essential amino acid intake is inadequate, but in contrast allows a large range of adaptive capacities through amino acid degradation and substrate interconversion...
- The role of gastrointestinal vagal afferents in the control of food intake: current prospectsG J Schwartz
Edward W Bourne Behavioral Research Laboratory, Weill Medical College of Cornell University, White Plains, New York, USA
Nutrition 16:866-73. 2000....
- Maternal nutrient restriction between early and midgestation and its impact upon appetite regulation after juvenile obesityS P Sebert
Centre for Reproduction and Early Life, Institute for Clinical Research, University Hospital, Nottingham, UK
Endocrinology 150:634-41. 2009..restriction during early-to-midgestation, a period coinciding with early fetal brain development, on appetite regulation and energy balance in the offspring after juvenile obesity was examined...
- Neuroendocrine regulation of food intakeScott Hagan
Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Pediatr Blood Cancer 58:149-53. 2012..A basic understanding of the structure-function of these systems will inform the challenges of clinical care for those with disorders of energy balance...
- Gut-brain cross-talk in appetite regulationJaimini Cegla
Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK
Curr Opin Clin Nutr Metab Care 13:588-93. 2010To review the role of gut hormones involved in appetite regulation and their potential in the treatment of obesity.
- Acute effects of an alcoholic drink on food intake: aperitif versus co-ingestionS J Caton
Department of Psychology, Glasgow Caledonian University, Glasgow, UK
Physiol Behav 90:368-75. 2007..However, lean healthy men adjusted total EI on the days following the laboratory in all conditions...
- Expression of the leptin receptor in rat and human nodose ganglion neuronesG Burdyga
Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, UK
Neuroscience 109:339-47. 2002....
- Appetite regulation: the central role of melatonin in Danio rerioChiara Carla Piccinetti
Dipartimento di Scienze del Mare, Universita Politecnica delle Marche, Via Brecce Bianche 60131, Ancona, Italy
Horm Behav 58:780-5. 2010..level and the effect of melatonin was considered in relation to the most prominent systems involved in appetite regulation. For the first time, in fact, melatonin control of food intake by the modulation of leptin, MC4R, ghrelin, ..
- The effects of insulin on the central nervous system--focus on appetite regulationR U Pliquett
University of Leipzig, Faculty of Medicine, III Medical Department, Leipzig, Germany
Horm Metab Res 38:442-6. 2006..Continuous efforts to understand hormonal effects on these pathways may advance our understanding of human obesity...
- Area postrema projects to FoxP2 neurons of the pre-locus coeruleus and parabrachial nuclei: brainstem sites implicated in sodium appetite regulationMatthew K Stein
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
Brain Res 1359:116-27. 2010..The HSD2 neurons are part of a central network involved in sodium appetite regulation, and they innervate numerous brain sites including the pre-locus coeruleus (pre-LC) and PB external lateral-..
- Weight gain is associated with reduced striatal response to palatable foodEric Stice
Department of Psychology, University of Texas, Austin, Texas 78712, USA
J Neurosci 30:13105-9. 2010..Collectively, results suggest that low sensitivity of reward circuitry increases risk for overeating and that this overeating may further attenuate responsivity of reward circuitry in a feedforward process...
- The effect of milk proteins on appetite regulation and diet-induced thermogenesisJ Lorenzen
Department of Human Nutrition, Centre for Advanced Food Studies, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
Eur J Clin Nutr 66:622-7. 2012..However, data on the effect of different types of protein are limited. In the present study we compare the effect of whey, casein and milk on DIT and satiety...
- CART in the dorsal vagal complex: sources of immunoreactivity and effects on Fos expression and food intakeHuiyuan Zheng
Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA
Brain Res 957:298-310. 2002..The functional role of CART in vagal afferents and the site of food intake suppression by 4th ventricular CARTp remain to be determined...
- The role of peptide YY in appetite regulation and obesityEfthimia Karra
Centre for Diabetes and Endocrinology, Department of Medicine, University College London, 5 University Street, London WC1E 6JJ, UK
J Physiol 587:19-25. 2009..Taken together these findings, coupled with the retained responsiveness of obese subjects to the effects of PYY3-36, suggest that targeting the PYY system may offer a therapeutic strategy to help treat obesity...
- The orexigenic activity of the hypothalamic neuropeptide 26RFa is mediated by the neuropeptide Y and proopiomelanocortin neurons of the arcuate nucleusBenoît Lectez
Equipe Associée à l université 4310 Institut National de la Santé et de la Recherche Médicale Unité 413, Neuronal and Neuroendocrine Differentiation and Communication, European Institute for Peptide Research, University of Rouen, F76031 Rouen, France
Endocrinology 150:2342-50. 2009..It is also suggested that the balance 26RFa/leptin is an important parameter in the maintenance of energy homeostasis...
- High-fructose corn syrup, energy intake, and appetite regulationKathleen J Melanson
Rippe Lifestyle Institute, Shrewsbury, MA 01545, USA
Am J Clin Nutr 88:1738S-1744S. 2008..The main objective of this review was to examine collective data on associations between consumption of HFCS and energy balance, with particular focus on energy intake and its regulation...
- Ghrelin, the peripheral hunger hormoneSusie C Higgins
Department of Endocrinology, Barts and the London Medical School, London, UK
Ann Med 39:116-36. 2007..Ghrelin levels change profoundly in anorexia, in states of insulin resistance, in obesity, and after bariatric surgery, suggesting that this is an important hormone in body weight regulation...
- Action of MT-II on ghrelin-induced feeding in the paraventricular nucleus of the hypothalamusYogendra B Shrestha
Department of Foods and Nutrition, Dawson Hall, University of Georgia, Athens, GA 30602, USA
Neuroreport 15:1365-7. 2004..This finding indicates that MC 3/4-R signaling appears to be recruited by ghrelin, in the PVN, in its role to induce feeding...
- A review of the effects of exercise on appetite regulation: an obesity perspectiveC Martins
Obesity Research Group, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Int J Obes (Lond) 32:1337-47. 2008In this review, we discuss the role of inactivity and exercise on appetite regulation, both in the short and long term, and the potential mechanisms involved...
- Experiential effects of appetitive and nonappetitive odors on feeding behavior in the blowfly, Phormia regina: a putative role for tyramine in appetite regulationTomoyosi Nisimura
Department of Applied Biology, Faculty of Textile Science, Kyoto Institute of Technology, Kyoto 606 8585, Japan
J Neurosci 25:7507-16. 2005..as representative nonappetitive and appetitive flavors, we demonstrated the role played by tyramine (TA) in appetite regulation by experiences of food flavors...
- Seasonal appetite regulation in the anadromous Arctic charr: evidence for a role of adiposity in the regulation of appetite but not for leptin in signalling adiposityEirik Frøiland
Faculty of Biosciences, fisheries and economy, University of Tromsø, N 9037 Tromsø, Norway
Gen Comp Endocrinol 178:330-7. 2012....
- Marked differences in gustatory and gastrointestinal sensitivity to oleic acid between lean and obese menJessica E Stewart
University of Adelaide Discipline of Medicine, Royal Adelaide Hospital, Adelaide, Australia
Am J Clin Nutr 93:703-11. 2011..Both orosensory stimulation and feedback from the gastrointestinal tract contribute to energy intake regulation...
- Role of neuropeptide Y and proopiomelanocortin in fluoxetine-induced anorexiaChang Seon Myung
Laboratory in Pharmacology, Chungnam National University College of Pharmacy, Daejeon 305 764, Korea
Arch Pharm Res 28:716-21. 2005..It is possible that a fluoxetine raised level of 5-HT play an inhibitory role in the orectic action caused by a reduced expression of ARC POMC (alpha-MSH)...
- Effect of eating rate on binge size in Bulimia NervosaHarry R Kissileff
St Luke s Roosevelt Hospital, New York, NY 10025, USA
Physiol Behav 93:481-5. 2008..NC subjects ate less at a slow rate. These findings indicate that in a structured laboratory meal paradigm binge size is not affected by rate of eating...
- Hypothalamus integrity and appetite regulation in low birth weight rats reared artificially on a high-protein milk formulaBérengère Coupé
INRA, Laboratoire de Physiologie des Adaptations Nutritionnelles, Universite de Nantes, Nantes atlantique, CHU Hotel Dieu, Place Alexis Ricordeau, France
J Nutr Biochem 22:956-63. 2011..The consequences of HP milk supplementation after LBW will be discussed in regard to neural development and metabolic anomalies...
- Body composition and appetite: fat-free mass (but not fat mass or BMI) is positively associated with self-determined meal size and daily energy intake in humansJohn E Blundell
BioPsychology Group, Institute of Psychological Sciences, University of Leeds, Leeds, UK
Br J Nutr 107:445-9. 2012..This signal may be postulated to interact with a separate class of signals generated by FM. This finding may have implications for investigations of the molecular control of food intake and body weight and for the management of obesity...
- Dual-process action of exercise on appetite control: increase in orexigenic drive but improvement in meal-induced satietyNeil A King
Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
Am J Clin Nutr 90:921-7. 2009..Exercise could contribute to weight loss by altering the sensitivity of the appetite regulatory system...
- Appetite regulation via exercise prior or subsequent to high-fat meal consumptionMary Huey Yu Cheng
School of Exercise and Nutritional Sciences, San Diego State University, United States
Appetite 52:193-8. 2009..These data indicated the timing of exercise to meal consumption may influence appetite and its hormonal regulators. Post-meal exercise may extend the suppressive effects of meal consumption on appetite...
- Interaction of leptin and nitric oxide on food intake in broilers and LeghornsS J Yang
Department of Neurology, Mount Sinai School of Medicine, New York, NY 10021, United States
Physiol Behav 92:651-7. 2007..The results showed leptin decreased NO formation significantly compared with the control group. These results suggest that NO interacts with leptin in the central nervous system to modulate feeding behavior in the chicken...
- Sensory-specific satiety in obese and normal-weight womenHarriëtte M Snoek
Netherlands Organization for Applied Scientific Research TNO Nutrition and Food Research, Zeist, Netherlands
Am J Clin Nutr 80:823-31. 2004..Sensory-specific satiety has been found to play an important role in food choice and meal termination, and it might be a factor contributing to obesity...
- The influence of physical activity on appetite control: an experimental system to understand the relationship between exercise-induced energy expenditure and energy intakePhillipa Caudwell
Institute of Psychological Sciences, Faculty of Medicine and Health, University of Leeds, Leeds LS2 9JT, UK
Proc Nutr Soc 70:171-80. 2011..This experimental platform provides opportunities for industry to examine the impact of foods under scientifically controlled conditions relevant to the real world...
- Focusing on food during lunch enhances lunch memory and decreases later snack intakeSuzanne Higgs
School of Psychology, University of Birmingham, Edgbaston, Birmingham, West Midlands, England B15 2TT, UK
Appetite 57:202-6. 2011..These results suggest that enhancing meal memory by paying attention to food while eating can reduce later intake and are consistent with the suggestion that memory plays an important role in appetite control...
- Estrogen inhibits NPY secretion through membrane-associated estrogen receptor (ER)-α in clonal, immortalized hypothalamic neuronsS S Dhillon
Department of Physiology, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada
Int J Obes (Lond) 35:198-207. 2011..This study was designed to investigate whether E(2) can directly regulate NPY secretion and examine the cellular mechanisms and receptors responsible for this anorexigenic action of E(2)...
- The cannabinoid system: a role in both the homeostatic and hedonic control of eating?Joanne A Harrold
Neuroendocrine and Obesity Biology Unit, Department of Medicine, University of Liverpool, University Clinical Departments, Liverpool L69 3GA, UK
Br J Nutr 90:729-34. 2003..With the cannabinoid system contributing to both regulatory pathways, it presents an attractive therapeutic target for the treatment of both obesity and eating disorders...
- The neuronal histamine H(1) and pro-opiomelanocortin-melanocortin 4 receptors: independent regulation of food intake and energy expenditureHironobu Yoshimatsu
Department of Internal Medicine, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Hasama, Oita 879 5593, Japan
Peptides 27:326-32. 2006....
- Novel therapeutic targets for appetite regulationCaroline J Small
Department of Metabolic Medicine, Division of Investigative Science, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 ONN, UK
Curr Opin Investig Drugs 6:369-72. 2005....
- Eating behaviour and weight in childrenL Webber
Department of Epidemiology and Public Health, University College London, Cancer Research UK Health Behaviour Research Centre, 2 16 Torrington Place, Gower Street, London, UK
Int J Obes (Lond) 33:21-8. 2009..To test the hypothesis that quantitative variation in eating behaviour traits shows a graded association with weight in children...
- Pharmacological characterization of the receptor mediating the anorexigenic action of the octadecaneuropeptide: evidence for an endozepinergic tone regulating food intakeJean Claude do Rego
CNRS FRE 2735, Laboratory of Experimental Neuropsychopharmacology, European Institute for Peptide Research IFRMP 23, Faculty of Medicine and Pharmacy, University of Rouen, Rouen Cedex, France
Neuropsychopharmacology 32:1641-8. 2007..The data also suggest that endogenous ODN, acting via this receptor, exerts an inhibitory tone on feeding behavior...
- Discrete neurochemical coding of distinguishable motivational processes: insights from nucleus accumbens control of feedingBrian A Baldo
Department of Psychiatry, University of Wisconsin Madison School of Medicine and Public Health, 6001 Research Park Blvd, Madison, WI, 53719, USA
Psychopharmacology (Berl) 191:439-59. 2007....
- Neurotransmitters in key neurons of the hypothalamus that regulate feeding behavior and body weightBjörn Meister
Karolinska Institutet, Department of Neuroscience, Retzius vag 8, S 171 77 Stockholm, Sweden
Physiol Behav 92:263-71. 2007....
- Ghrelin--a hormone with multiple functionsMarta Korbonits
Department of Endocrinology, St Bartholomew s Hospital, London EC1A 7BE, UK
Front Neuroendocrinol 25:27-68. 2004..its receptor; (ii) the available information regarding the effect of ghrelin on the pituitary hormone axis, appetite regulation, cardiac and gastrointestinal function, carbohydrate metabolism, adipose and reproductive tissue, cell ..
- Cholecystokinin and satiety: current perspectivesT H Moran
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nutrition 16:858-65. 2000....
- Gastrointestinal targets of appetite regulation in humansN Delzenne
Louvain Drug Research Institute, Unit PMNT 7369, Universite Catholique de Louvain, Brussels, Belgium
Obes Rev 11:234-50. 2010..on new developments in techniques and methods for the assessment of physiological targets involved in appetite regulation (including brain imaging, interesting new experimental approaches, targets and markers)...
- Orexins and appetite regulationR J Rodgers
School of Psychology, University of Leeds, Leeds, UK
Neuropeptides 36:303-25. 2002..significance of two novel hypothalamic neuropeptides, orexin-A and orexin-B, suggested an important role in appetite regulation. Since then, however, these peptides have also been shown to influence a wide range of other physiological ..
- Peripheral injection of CCK-8S induces Fos expression in the dorsomedial hypothalamic nucleus in ratsPeter Kobelt
Department of Medicine, Division Hepatology, Gastroenterology, and Endocrinology, Charite, Campus Virchow, Humboldt Universitat zu Berlin, Germany
Brain Res 1117:109-17. 2006..These data indicate that in addition of the PVN, peripheral CCK increases neuronal activity in the DMH suggesting a possible role in this hypothalamic nucleus in the satiating effect of the peptide...
- Glucose sensing by hypothalamic neurones and pancreatic islet cells: AMPle evidence for common mechanisms?Philip D Mountjoy
Department of Cell Biology, Division of Medicine, Faculty of Medicine, Sir Alexander Fleming Building, Exhibition Road, Imperial College London, London SW7 2AZ, UK
Exp Physiol 92:311-9. 2007..In this review, we discuss recent advances in this field and explore the potential involvement of AMP-activated protein kinase and other nutrient-regulated protein kinases...
- Role of endogenous ghrelin in growth hormone secretion, appetite regulation and metabolismEleni V Dimaraki
Department of Medicine, Division of Endocrinology and Metabolic Diseases, Evanston Northwestern Healthcare and Northwestern University Feinberg School of Medicine, Evanston, IL 60201, USA
Rev Endocr Metab Disord 7:237-49. 2006..Presence of ghrelin appears to be necessary for the development of obesity in some animal models. Whether abnormalities in ghrelin signaling are involved in human obesity is not yet known...
- Central actions of neuromedin U via corticotropin-releasing hormoneTakeshi Hanada
Third Department of Internal Medicine, Miyazaki Medical College, 889 1692, Miyazaki, Japan
Biochem Biophys Res Commun 311:954-8. 2003..These results suggest that NMU plays a role in feeding behavior and catabolic functions via CRH. This study demonstrates a novel hypothalamic pathway that links NMU and CRH in the regulation of feeding behavior and energy homeostasis...
- Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgeryDavid E Cummings
Department of Medicine, University of Washington the Veterans Affairs Puget Sound Health Care System, Seattle 98108, USA
N Engl J Med 346:1623-30. 2002..Because ghrelin is produced primarily by the stomach, weight loss after gastric bypass surgery may be accompanied by impaired ghrelin secretion...
- Appetite regulation: from the gut to the hypothalamusNicola Marguerite Neary
Department of Metabolic Medicine, Faculty of Medicine, Imperial College of Science Technology and Medicine, Hammersmith Campus, London, UK
Clin Endocrinol (Oxf) 60:153-60. 2004
- Serotonin 5-HT2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptorsDaniel D Lam
Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, United Kingdom
Endocrinology 149:1323-8. 2008..X warrants further investigation as a treatment for obesity but also elucidate specific neuronal pathways potently affecting energy balance through which 5-HT(2C)R agonists regulate ingestive behavior...
- Shedding light on the intricate puzzle of ghrelin's effects on appetite regulationBlerina Kola
Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Centre for Endocrinology, Queen Mary University of London, Charterhouse Square, London, UK
J Endocrinol 202:191-8. 2009..the appetite-inducing effect of ghrelin in the hypothalamus, shedding light on the intricate mechanisms of appetite regulation. AMP-activated protein kinase (AMPK) is a key metabolic enzyme involved in appetite regulation...
- The hardship of obesity: a soft-wired hypothalamusTamas L Horvath
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA
Nat Neurosci 8:561-5. 2005....
- Gut hormones as potential new targets for appetite regulation and the treatment of obesityBenjamin C T Field
Department of Metabolic Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK
Drugs 68:147-63. 2008..This review discusses both the role of gut hormones in appetite regulation, and the current state of development of gut hormone-based obesity therapies, with a particular focus on ..
- Discovery metabolite profiling of the prolyl peptidasesAlan Saghatelian; Fiscal Year: 2009..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
- The gastric X/A-like (ghrelin) cell: A peripheral regulator of food intakeNILS WG LAMBRECHT; Fiscal Year: 2012..The proposed studies will address important pathophysiological questions regarding the mechanisms regulating appetite and satiety as well as provide potentially important clinical treatment strategies. ..
- Impact of the P479L Variant in CPT1A on Infant Mortality in AlaskaDavid M Koeller; Fiscal Year: 2011..Alterations of energy metabolism resulting from dysregulation of CPT1 affects insulin sensitivity, appetite regulation, and a growing list of other critical functions that are tied to fatty acid metabolism...
- Weight gain, type 2 diabetes, and factors that affect neuroendocrine functionEDWARD ANTONIO RUIZ-NARVAEZ; Fiscal Year: 2013..The proposed study will provide novel data on factors that may be contributing to the epidemic of obesity and T2D in AA women and in other population groups as well. ..
- Endocannabinoid DiscriminationJenny L Wiley; Fiscal Year: 2013..The system plays an important modulatory role in many crucial CNS processes (e.g., brain reward, appetite regulation, cognition)...
- Endocannabinoid Intracellular TransportersDale G Deutsch; Fiscal Year: 2010..drug target may lead to treatment for addiction, mood disorders, pain and inflammation, cognition, and appetite regulation. For example, competitive inhibitors of AEA and 2-AG binding to specific FABPs will decrease the hydrolysis ..
- CONNECTIONS OF THE LIMBIC SYSTEM AND HYPOTHALAMUSLarry W Swanson; Fiscal Year: 2012..type analysis, starting with certain lateral hypothalamic regions apparently involved critically in food appetite regulation;and c) to facilitate the entry of neuroanatomical data into neuroinformatics workbenches on the web...
- Drosophila feeding behavior: New tools for the genetic dissection of prandiologyWilliam W Ja; Fiscal Year: 2012..A better understanding of appetite regulation will lead to better methods for controlling food intake, and therefore to better treatments for food-..
- Appetite: Serotonin and corticotropin releasing factorSuJean Choi; Fiscal Year: 2012..5-HT is further supported by data demonstrating the presence of mRNAs for 5-HT receptor subtypes linked to appetite regulation in PVN CRF cell bodies...
- Endocannabinoid modulation of pain-depressed behaviorLAURA J SIMSELLEY; Fiscal Year: 2013..The system plays an important modulatory role in many crucial CNS processes (e.g., brain reward, appetite regulation, cognition)...
- Neuropeptide Modulation of Taste SignalsNirupa Chaudhari; Fiscal Year: 2010..Ironically, the most intuitive driver of feeding, taste, has not been investigated as a contributor to appetite regulation. We present evidence and propose to study further, how the taste system may be modulated by at least two of ..
- Characterization of a mutation that affects feeding and digestion in DrosophilaEDWARD BLUMENTHAL; Fiscal Year: 2009..this mutant should prove to be an excellent starting point for future studies into the genetics of appetite regulation and digestive physiology...
- Pathways Linking Reduced Sleep Duration and Quality to Obesity RiskEsra Tasali; Fiscal Year: 2009..reductions of sleep quality without change in sleep duration results in alterations of glucose and appetite regulation that could also lead to an increased risk of obesity...
- Epigenetic mechanisms in obesityRobert A Waterland; Fiscal Year: 2012....
- The TSC-mTOR pathway in cellular and organismal energy metabolismKun Liang Guan; Fiscal Year: 2013..This proposal will investigate the function of TSC-mTOR in affecting leptin signaling and appetite control. The information generated from this project will provide new insights into to appetite regulation, obesity, and diabetes.
- Mindfulness Based Weight Loss MaintenanceRUTH QUILLIAN WOLEVER; Fiscal Year: 2010..Taken together, these data could provide support for the integration of mindfulness meditation into comprehensive treatment programs for obesity and weight management. ..
- Endocannabinoid Inactivation:Plasma Membrane Uptake and Cellular TraffickingDale G Deutsch; Fiscal Year: 2012..From a health related viewpoint, understanding the mechanism of endocannabinoid inactivation may lead to drug targets for addiction, mood disorders, pain and inflammation, cognition, and appetite regulation.
- Training Grant in Diabetes, Endocrinology and MetabolismElizabeth R Seaquist; Fiscal Year: 2013..of our faculty include cellular metabolism and genetics;endocrinology and signaling;neurobiology and appetite regulation of obesity;stem cell biology, autoimmunity, and b-cell biology;and clinical aspects of endocrine disease...
- Training Program in Nutrition and MetabolismSTEVEN KYLE GRINSPOON; Fiscal Year: 2013..development and bone health, HIV, Vitamin D metabolism, genomic and metabolomics, epidemiology, obesity and appetite regulation, and nutrient trafficking. The grant draws from a large group of highly successful faculty across Harvard...
- Screening Method for GPCRs Related to AppetiteMARIA MORANO; Fiscal Year: 2009..development arise from the recent explosion of information on molecules and neural circuits involved in appetite regulation. This proposal focuses on developing testing platforms for GPCR families associated with feeding behavior...
- Stress, Appetite, and Smoking RelapseMUSTAFA N AL'ABSI; Fiscal Year: 2013..goal of our research is to delineate the interactions of neurobiological mechanisms responsible for appetite regulation and tobacco addiction...
- Effect of Pre and Postnatal Nutritional Programming on SCD1 Activity and ObesityJennifer K Yee; Fiscal Year: 2011..W.N. Paul Lee, an expert in intermediary metabolism, and Co-Sponsor Dr. Michael Ross, an expert in appetite regulation in nutritional programming. Collaborator Mina Desai will also support Dr. Yee's research training...
- Effect Of Weight-Increased Psychotropic Medications on Appetite RegulationKIMBERLY ANN BROWNLEY; Fiscal Year: 2010..Ultimately, information gained from this study may be instrumental in reducing obesity and obesity-related morbidities in patients with severe mental illness. ..
- Neural Mechanisms of Overeating in Prader-Willi SyndromeAnastasia Dimitropoulos; Fiscal Year: 2009..as indicated by increased brain activation in the frontal and limbic regions of the brain implicated in appetite regulation. However, individuals with PWS also show clear preference for foods based on their taste and macronutrient ..
- FEEDBACK REGULATION OF PANCREATIC SECRETIONGary Green; Fiscal Year: 2000....
- ASSOCIATIVE CONDITIONING OF CHILDREN'S FOOD PREFERENCESLeann Birch; Fiscal Year: 1992..The results will contribute to the knowledge base for the development of intervention strategies needed to meet current dietary guidelines, which call for reducing dietary fat intake...
- Screening Method for GPCRs Related to AppetiteCAMILLE NORTON; Fiscal Year: 2004..development arise from the recent explosion of information on molecules and neural circuits involved in appetite regulation. This proposal focuses on developing testing platforms for two GPCR families associated with feeding ..
- Silencing Hypothalamic Galanin with RNA InterferenceSuJean Choi; Fiscal Year: 2005....
- An interdisciplinary study of eating behavior in twinsEllen Schur; Fiscal Year: 2009..training and research activities focus on complex environmental and genetic influences on eating habits and appetite regulation. The application proposes an intensive, 5-year program of mentored research and formal training activities ..
- MOLECULAR BIOLOGY OF MUTANT 5-HT2C SEROTONIN RECEPTORSKatharine Herrick Davis; Fiscal Year: 2006..in the CNS, they have been implicated in mental disorders, neuroendocrine regulation, CSF production and appetite regulation. Previous studies have shown that mutant, inactive GPCR can decrease the ability of native receptors to ..
- FAMILY SYSTEMS APPROACH TO CHILDHOOD OBESITYSusan Johnson; Fiscal Year: 2000..The long-term goal of this line of research is to identify points at which effective intervention and prevention strategies can be developed. ..
- CYCLO(HIS-PRO)--A NEW SATIETY NEUROPEPTIDEJohn Wilber; Fiscal Year: 1990It is proposed to investigate four interrelated areas concerning cyclo-(His-Pro) (C(HP)) and appetite regulation. The long range goal is to understand how C(HP) causes appetite suppression and to achieve long-term appetite suppression in ..
- Mindfulness-Based Weight Loss MaintenanceMichael Baime; Fiscal Year: 2007..Taken together, these data could provide support for the integration of mindfulness meditation into comprehensive treatment programs for obesity and weight management. [unreadable]..
- Energy and Appetite Regulation by High and Low CHO DietsDiane Stadler; Fiscal Year: 2008..These results will be used to design hypothesis-driven studies of the identified mediators of appetite and weight regulation in response to dietary manipulation. ..
- Non-Homeostatic Neural Controls of Food IntakeHans Rudolf Berthoud; Fiscal Year: 2010..abstract_text> ..
- FUNCTIONAL ORGANIZATION OF THE VAGAL-ENTERIC INTERFACEHans Rudolf Berthoud; Fiscal Year: 2003..abstract_text> ..
- Metabolic and Epigenetic Effects of Maternal High Fat Diet in Obesity Prone RatsTimothy H Moran; Fiscal Year: 2010..The results of these experiments will enhance our understanding of the etiology of obesity and metabolic disease ultimately allowing the development of rational clinical interventions for such conditions. ..
- Low Carbohydrate Diets: Feeding and Endocrine SignalingTimothy Moran; Fiscal Year: 2006..abstract_text> ..
- Society for the Study of Ingestive Behavior Annual MeetTimothy Moran; Fiscal Year: 2003..abstract_text> ..
- LEPTIN ACTION ON HYPOTHALAMIC PEPTIDES GOVERNING FEEDINGAbhiram Sahu; Fiscal Year: 2001..These studies will further our understanding of leptin signaling in the hypothalamus in relation to feeding, and therefore will be relevant to the development of therapeutic approaches to eating disorders. ..
- Urocortins Brain CRF2 Receptors and Energy BalanceEric P Zorrilla; Fiscal Year: 2010....
- Role of the CRF2 Receptor in Ingestive BehaviorEric Zorrilla; Fiscal Year: 2005..Several findings, however, have spurred interest in the role of the CRF2 receptor in appetite regulation. Unfortunately, selective ligands for the CRF2 receptor have not been available, precluding pharmacological ..
- Galanin Control of Food Intake: Molecular, Neuroanatomical and Behavioral BasesEric P Zorrilla; Fiscal Year: 2010....
- Programmed adiposity: genetic in utero and postnatal determinantsEric Zorrilla; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Mechanisms of Leptin Signaling in the HypothalamusAbhiram Sahu; Fiscal Year: 2007..These studies will further our understanding of leptin signaling in the hypothalamus in relation to feeding, and therefore will be relevant to the development of therapeutic approaches to eating disorders. [unreadable] [unreadable]..
- CEPHALIC RESPONSES AND MEAL FEEDINGStephen Woods; Fiscal Year: 2008..unreadable] [unreadable]..
- POST-PRANDIAL NUTRIENT PARTITIONING IN HUMANSMarc Andre Cornier; Fiscal Year: 2005..These studies will provide insight into the biology that predisposes to weight gain and regain and will lay the groundwork for future studies of the abnormalities in nutrient metabolism that exist in obese and preobese individuals. ..
- Neuropharmacology of Learned Food PreferencesAnthony Sclafani; Fiscal Year: 2009..It will advance our understanding of the basic mechanisms involved in the development of food preferences and may provide insights into the clinical treatment of overeating and obesity. ..
- HYPOTHALAMIC NEUROTRANSMITTER SYSTEMS & EATING BEHAVIORSarah F Leibowitz; Fiscal Year: 2010..In summary, this grant tests the novel hypothesis that a high-fat diet itself can promote overeating and ultimately dietary obesity through a positive feedback loop involving circulating lipids, hypothalamic peptides and accumbens DA. ..
- Role of Acetaldehyde in Alcoholic CardiomyopathyJun Ren; Fiscal Year: 2008..Our long-term goal is to establish the toxic mechanism of acetaldehyde in the development of alcoholic cardiomyopathy so that prevention and treatment can be optimized [unreadable] [unreadable]..
- DIETARY OBESITYGeorge Bray; Fiscal Year: 2007..We now propose these well founded, important and exciting studies which will provide critical new insights into anatomical, physiological and molecular mechanisms by which high levels of dietary fat induce obesity. ..
- Meal Initiation and Energy Homeostasis: Role of GhrelinDavid Cummings; Fiscal Year: 2009..parenteral nutrients, gastric distension, specific classes of macronutrients, leptin, fasting, and other meal-regulated gut peptides. 4) Is ghrelin effective as a drug to treat cancer anorexia in a rat model? ..
- ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBSMichael Camilleri; Fiscal Year: 2007..abstract_text> ..
- CNS Stress Pathways and the Development of Acute HAAFDianne Lattemann; Fiscal Year: 2003..abstract_text> ..
- IGF-1, Oxidative Stress and Cardiovascular AgingJun Ren; Fiscal Year: 2002..Our long-term goal is to establish the causal link among IGF-1 deficiency, enhanced oxidative damage and ventricular dysfunction in the progression of cardiovascular aging so that hormonal or antioxidant therapy can be optimized...
- Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory FunctionsMICHAEL L CAMILLERI; Fiscal Year: 2010..These actions may be relevant to develop new treatments for IBS. The studies will also provide further understanding of the potential of medications like medical marijuana on stomach function that may be relevant to appetite control. ..
- NEURAL AND GI SUBSTRATES IN BOMBESIN SATIETYELLEN LADENHEIM; Fiscal Year: 2006..Such an understanding will significantly enhance our understanding of the mechanisms underlying overall energy regulation and may lead to novel treatments for obesity or eating disorders ..
- CNS Action of Appetite Suppressant AminosterolRexford S Ahima; Fiscal Year: 2010..Understanding of the central neuronal actions MSI-1436 may elucidate novel targets for the treatment of obesity and related diseases. ..