appetite

Summary

Summary: Natural recurring desire for food.

Top Publications

  1. ncbi Ghrelin enhances appetite and increases food intake in humans
    A M Wren
    Endocrine Unit, Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN, United Kingdom
    J Clin Endocrinol Metab 86:5992. 2001
  2. ncbi Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite
    Karine Spiegel
    University of Chicago, Chicago, Illinois, USA
    Ann Intern Med 141:846-50. 2004
  3. pmc Beverage consumption, appetite, and energy intake: what did you expect?
    Bridget A Cassady
    Department of Nutrition Science, Purdue University, West Lafayette, IN 47907 2059, USA
    Am J Clin Nutr 95:587-93. 2012
  4. pmc Effects of fructose vs glucose on regional cerebral blood flow in brain regions involved with appetite and reward pathways
    Kathleen A Page
    Section of Endocrinology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8020, USA
    JAMA 309:63-70. 2013
  5. ncbi Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies
    A Flint
    Research Department of Human Nutrition, Center for Food Research, The Royal Veterinary and Agricultural University, DK 1958 Frederiksberg C, Denmark
    Int J Obes Relat Metab Disord 24:38-48. 2000
  6. ncbi A meta-analysis of the effect of glucagon-like peptide-1 (7-36) amide on ad libitum energy intake in humans
    C Verdich
    Research Department of Human Nutrition, Centre for Food, The Royal Veterinary and Agricultural University, DK-1958 Frederiksberg C, Denmark
    J Clin Endocrinol Metab 86:4382-9. 2001
  7. ncbi The effects of exercise-induced weight loss on appetite-related peptides and motivation to eat
    C Martins
    Obesity Research Group, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    J Clin Endocrinol Metab 95:1609-16. 2010
  8. ncbi Weight loss, appetite suppression, and changes in fasting and postprandial ghrelin and peptide-YY levels after Roux-en-Y gastric bypass and sleeve gastrectomy: a prospective, double blind study
    Stavros N Karamanakos
    Nutrition Support and Morbid Obesity Unit, Department of Surgery, University of Patras School of Medicine, Patras, Greece
    Ann Surg 247:401-7. 2008
  9. ncbi Gut hormone PYY(3-36) physiologically inhibits food intake
    Rachel L Batterham
    Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Nature 418:650-4. 2002
  10. ncbi Inhibition of food intake in obese subjects by peptide YY3-36
    Rachel L Batterham
    Department of Metabolic Medicine, Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Rd, London W12 0NN, United Kingdom
    N Engl J Med 349:941-8. 2003

Detail Information

Publications358 found, 100 shown here

  1. ncbi Ghrelin enhances appetite and increases food intake in humans
    A M Wren
    Endocrine Unit, Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN, United Kingdom
    J Clin Endocrinol Metab 86:5992. 2001
    ..The effect of ghrelin on appetite and food intake in man has not been determined. We investigated the effects of intravenous ghrelin (5...
  2. ncbi Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite
    Karine Spiegel
    University of Chicago, Chicago, Illinois, USA
    Ann Intern Med 141:846-50. 2004
    ..Total sleep deprivation in rodents and in humans has been associated with hyperphagia. Over the past 40 years, self-reported sleep duration in the United States has decreased by almost 2 hours...
  3. pmc Beverage consumption, appetite, and energy intake: what did you expect?
    Bridget A Cassady
    Department of Nutrition Science, Purdue University, West Lafayette, IN 47907 2059, USA
    Am J Clin Nutr 95:587-93. 2012
    ..Beverage consumption is implicated in the overweight/obesity epidemic through the weaker energy compensation response it elicits compared with solid food forms. However, plausible mechanisms are not documented...
  4. pmc Effects of fructose vs glucose on regional cerebral blood flow in brain regions involved with appetite and reward pathways
    Kathleen A Page
    Section of Endocrinology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8020, USA
    JAMA 309:63-70. 2013
    ..Fructose ingestion produces smaller increases in circulating satiety hormones compared with glucose ingestion, and central administration of fructose provokes feeding in rodents, whereas centrally administered glucose promotes satiety...
  5. ncbi Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies
    A Flint
    Research Department of Human Nutrition, Center for Food Research, The Royal Veterinary and Agricultural University, DK 1958 Frederiksberg C, Denmark
    Int J Obes Relat Metab Disord 24:38-48. 2000
    To examine reproducibility and validity of visual analogue scales (VAS) for measurement of appetite sensations, with and without a diet standardization prior to the test days.
  6. ncbi A meta-analysis of the effect of glucagon-like peptide-1 (7-36) amide on ad libitum energy intake in humans
    C Verdich
    Research Department of Human Nutrition, Centre for Food, The Royal Veterinary and Agricultural University, DK-1958 Frederiksberg C, Denmark
    J Clin Endocrinol Metab 86:4382-9. 2001
    ..following subject data were included if available: plasma concentrations of glucagon-like peptide-1, subjective appetite measures, well-being, and gastric emptying rate of a meal served at the start of the glucagon-like peptide-1 ..
  7. ncbi The effects of exercise-induced weight loss on appetite-related peptides and motivation to eat
    C Martins
    Obesity Research Group, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    J Clin Endocrinol Metab 95:1609-16. 2010
    ..An increase in energy intake is likely to result from changes in the appetite control system toward an orexigenic environment; however, few studies have measured how exercise impacts on both ..
  8. ncbi Weight loss, appetite suppression, and changes in fasting and postprandial ghrelin and peptide-YY levels after Roux-en-Y gastric bypass and sleeve gastrectomy: a prospective, double blind study
    Stavros N Karamanakos
    Nutrition Support and Morbid Obesity Unit, Department of Surgery, University of Patras School of Medicine, Patras, Greece
    Ann Surg 247:401-7. 2008
    ..Bariatric surgery is currently the most effective treatment in morbidly obese patients, leading to durable weight loss...
  9. ncbi Gut hormone PYY(3-36) physiologically inhibits food intake
    Rachel L Batterham
    Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Nature 418:650-4. 2002
    ..In humans, infusion of normal postprandial concentrations of PYY(3-36) significantly decreases appetite and reduces food intake by 33% over 24 h...
  10. ncbi Inhibition of food intake in obese subjects by peptide YY3-36
    Rachel L Batterham
    Department of Metabolic Medicine, Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Rd, London W12 0NN, United Kingdom
    N Engl J Med 349:941-8. 2003
    The gut hormone fragment peptide YY3-36 (PYY) reduces appetite and food intake when infused into subjects of normal weight...
  11. pmc A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure
    Vijay K Yadav
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Cell 138:976-89. 2009
    ..The same is true for its regulation of appetite and energy expenditure. This suggests that leptin acts elsewhere in the brain to achieve these three functions...
  12. pmc Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite
    Alfonso Abizaid
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06519, USA
    J Clin Invest 116:3229-39. 2006
    ..Taken together, these data suggest that the mesolimbic reward circuitry is targeted by peripheral ghrelin to influence physiological mechanisms related to feeding...
  13. ncbi Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal
    Patrice D Cani
    Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Universite Catholique de Louvain, Brussels, Belgium
    Am J Clin Nutr 90:1236-43. 2009
    ..In rodents, these effects are associated with an increase in plasma gut peptide concentrations, which are involved in appetite regulation and glucose homeostasis.
  14. pmc Restraint of appetite and reduced regional brain volumes in anorexia nervosa: a voxel-based morphometric study
    Samantha J Brooks
    Section of Eating Disorders, Institute of Psychiatry, King s College London, London, SE5 8AF UK
    BMC Psychiatry 11:179. 2011
    ..This study aimed to provide preliminary extensions of this data by examining how different levels of appetitive restraint impact on brain volume...
  15. ncbi Images of desire: food-craving activation during fMRI
    Marcia Levin Pelchat
    Monell Chemical Senses Center, Philadelphia, PA 19104 3308, USA
    Neuroimage 23:1486-93. 2004
    ..Craving-related changes in fMRI signal were identified in the hippocampus, insula, and caudate, three areas reported to be involved in drug craving. Thus, this work supports the common substrate hypothesis for food and drug cravings...
  16. pmc Metabolic and hedonic drives in the neural control of appetite: who is the boss?
    Hans Rudolf Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    Curr Opin Neurobiol 21:888-96. 2011
    ....
  17. pmc Neuroimaging and obesity: current knowledge and future directions
    S Carnell
    New York Obesity Nutrition Research Center, Department of Medicine, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Obes Rev 13:43-56. 2012
    ..increasingly common in obesity research as investigators try to understand the neurological underpinnings of appetite and body weight in humans...
  18. ncbi Pictures of appetizing foods activate gustatory cortices for taste and reward
    W Kyle Simmons
    Department of Psychology, Emory University, Atlanta, GA 30322, USA
    Cereb Cortex 15:1602-8. 2005
    ..Consistent with theories that ground knowledge in the modalities, these inferences arise as reenactments of modality-specific processing...
  19. ncbi Hormonal regulation of food intake
    Sarah Stanley
    Endocrine Unit, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Physiol Rev 85:1131-58. 2005
    ..This review discusses the peripheral hormones and central neuronal pathways that contribute to control of appetite.
  20. ncbi Effects of high-fructose corn syrup and sucrose consumption on circulating glucose, insulin, leptin, and ghrelin and on appetite in normal-weight women
    Kathleen J Melanson
    Department of Nutrition and Food Sciences, University of Rhode Island, Kingston, Rhode Island, USA
    Nutrition 23:103-12. 2007
    ..This study examined effects of beverages sweetened with HFCS or sucrose (Suc), when consumed with mixed meals, on blood glucose, insulin, leptin, ghrelin, and appetite.
  21. ncbi Stress may add bite to appetite in women: a laboratory study of stress-induced cortisol and eating behavior
    E Epel
    UCSF Health Psychology Program, 3333 California St, Suite 465, San Francisco, CA 94118, USA
    Psychoneuroendocrinology 26:37-49. 2001
    ..These results suggest that psychophysiological response to stress may influence subsequent eating behavior. Over time, these alterations could impact both weight and health...
  22. pmc Deletion of ghrelin impairs neither growth nor appetite
    Yuxiang Sun
    Department of Molecular and Cellular Biology, Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 23:7973-81. 2003
    Pharmacological studies show that ghrelin stimulates growth hormone release, appetite, and fat deposition, but ghrelin's physiological role in energy homeostasis has not been established...
  23. ncbi Nature and nurture in infant appetite: analysis of the Gemini twin birth cohort
    Clare H Llewellyn
    Cancer Research UK Health Behaviour Research Centre, Department of Epidemiology and Public Health, University College London, London, United Kingdom
    Am J Clin Nutr 91:1172-9. 2010
    A strong genetic influence on appetitive traits has been shown in children and adults, but no studies have examined appetite in early infancy, even though avidity of appetite has been linked with a higher risk of obesity.
  24. pmc The effects of hedonically acceptable red pepper doses on thermogenesis and appetite
    Mary Jon Ludy
    Purdue University, West Lafayette, IN 47907, USA
    Physiol Behav 102:251-8. 2011
    ..of hedonically acceptable RP doses served at a single meal in healthy, lean individuals on thermogenesis and appetite. Twenty-five men and women (aged 23.0 ± 0.5 years, BMI 22.6 ± 0...
  25. pmc Control of blood pressure, appetite, and glucose by leptin in mice lacking leptin receptors in proopiomelanocortin neurons
    Jussara M do Carmo
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State St, Jackson, MS 39216, USA
    Hypertension 57:918-26. 2011
    ..of energy balance, the role of proopiomelanocortin (POMC) neurons in mediating the chronic effects of leptin on appetite, blood pressure, and glucose regulation is unknown...
  26. pmc Fgf10-expressing tanycytes add new neurons to the appetite/energy-balance regulating centers of the postnatal and adult hypothalamus
    Niels Haan
    School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, United Kingdom
    J Neurosci 33:6170-80. 2013
    ..These studies provide direct evidence in support of hypothalamic neurogenesis during late postnatal and adult life, and identify Fgf10(+) tanycytes as a source of parenchymal neurons with putative roles in appetite and energy balance.
  27. pmc Effects of food form and timing of ingestion on appetite and energy intake in lean young adults and in young adults with obesity
    Richard D Mattes
    Department of Foods and Nutrition, Purdue University, 212 Stone Hall, 700 W State St, West Lafayette, IN 47907 2059, USA
    J Am Diet Assoc 109:430-7. 2009
    Overweight and obesity have been attributed to increased eating frequency and the size of eating events. This study explored the influence of the timing of eating events and food form on appetite and daily energy intake.
  28. ncbi Effect of the once-daily human GLP-1 analogue liraglutide on appetite, energy intake, energy expenditure and gastric emptying in type 2 diabetes
    Michael Horowitz
    University of Adelaide Discipline of Medicine, Royal Adelaide Hospital, Adelaide, Australia
    Diabetes Res Clin Pract 97:258-66. 2012
    ..Liraglutide reduces bodyweight in patients with type 2 diabetes mellitus (T2DM). This study aimed to investigate the mechanisms underlying this effect...
  29. pmc Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway
    Kristy L Townsend
    Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    FASEB J 26:2187-96. 2012
    ..In the current study, we have uncovered a novel role for BMP7 in appetite regulation...
  30. ncbi The brain, appetite, and obesity
    Hans Rudolf Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Annu Rev Psychol 59:55-92. 2008
    ..The predisposition to develop obesity can theoretically result from any pathological malfunction or lack of adaptation to changing environments of this highly complex system...
  31. pmc Breakfast frequency and quality may affect glycemia and appetite in adults and children
    Mark A Pereira
    Division of Epidemiology and Community Health, School of Public Health, Minneapolis, MN 55454, USA
    J Nutr 141:163-8. 2011
    ..studies to examine some of the effects of breakfast skipping and breakfast composition on blood glucose and appetite in children and adults...
  32. ncbi The effects of miglitol on glucagon-like peptide-1 secretion and appetite sensations in obese type 2 diabetics
    A Lee
    Department of Medicine, St Louis University Medical Center, and GRECC, St Louis VA Medical Center, St Louis, MO, USA
    Diabetes Obes Metab 4:329-35. 2002
    ..GLP-1 plays a role to mediate satiety. Any agent that substantially elevates GLP-1 levels may theoretically reduce hunger, increase satiation and limit food intake...
  33. ncbi Effects of food form on appetite and energy intake in lean and obese young adults
    D M Mourao
    Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907 2059, USA
    Int J Obes (Lond) 31:1688-95. 2007
    To investigate the independent effect of food form on appetite and energy intake in lean and obese adults using high carbohydrate, fat or protein food stimuli.
  34. ncbi Hedonic hunger: a new dimension of appetite?
    Michael R Lowe
    Department of Psychology, Drexel University, Philadelphia, PA 19102, USA
    Physiol Behav 91:432-9. 2007
    ..This measure, combined with environmental manipulations of food availability and palatability, may constitute a useful approach to studying hedonic hunger...
  35. ncbi Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues
    D E Cummings
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Am J Physiol Endocrinol Metab 287:E297-304. 2004
    ....
  36. pmc Central control of body weight and appetite
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45237, USA
    J Clin Endocrinol Metab 93:S37-50. 2008
    ..Energy balance is critical for survival and health, and control of food intake is an integral part of this process. This report reviews hormonal signals that influence food intake and their clinical applications...
  37. pmc The effects of overfeeding on the neuronal response to visual food cues in thin and reduced-obese individuals
    Marc Andre Cornier
    Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado Denver, Aurora, Colorado, United States of America
    PLoS ONE 4:e6310. 2009
    ..The objective of this study was to examine the effects of short-term overfeeding on the neuronal response to food-related visual stimuli in individuals prone and resistant to weight gain...
  38. pmc Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor
    Yuxiang Sun
    Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:4679-84. 2004
    ..To address whether the GHSR mediates ghrelin's stimulatory effects on GH release and appetite, we generated Ghsr-null mice...
  39. ncbi Appetite assessment: simple appetite questionnaire predicts weight loss in community-dwelling adults and nursing home residents
    Margaret Mary G Wilson
    Division of Geriatric Medicine, Saint Louis University, St Louis, MO 63104, USA
    Am J Clin Nutr 82:1074-81. 2005
    ..Without a simple tool to evaluate appetite, health care providers often use inaccurate surrogates, such as measurement of energy consumption and nutritional ..
  40. pmc The gut hormones PYY 3-36 and GLP-1 7-36 amide reduce food intake and modulate brain activity in appetite centers in humans
    Akila De Silva
    Section of Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK
    Cell Metab 14:700-6. 2011
    Obesity is a major public health issue worldwide. Understanding how the brain controls appetite offers promising inroads toward new therapies for obesity...
  41. ncbi Effects of dietary fibre on subjective appetite, energy intake and body weight: a systematic review of randomized controlled trials
    A J Wanders
    Division of Human Nutrition, Wageningen University, The Netherlands
    Obes Rev 12:724-39. 2011
    Dietary fibres are believed to reduce subjective appetite, energy intake and body weight. However, different types of dietary fibre may affect these outcomes differently...
  42. pmc Nonnutritive sweetener consumption in humans: effects on appetite and food intake and their putative mechanisms
    Richard D Mattes
    Department of Foods and Nutrition, Purdue University, West Lafayette, IN, USA
    Am J Clin Nutr 89:1-14. 2009
    ..critical review of the literature suggests that the addition of NNS to non-energy-yielding products may heighten appetite, but this is not observed under the more common condition in which NNS is ingested in conjunction with other ..
  43. pmc Deciphering a neuronal circuit that mediates appetite
    Qi Wu
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Nature 483:594-7. 2012
    ..We also show that suppressing glutamatergic output of the PBN reinstates normal appetite after AgRP neuron ablation, whereas it promotes weight gain without AgRP neuron ablation...
  44. ncbi Effects of a high-protein ketogenic diet on hunger, appetite, and weight loss in obese men feeding ad libitum
    Alexandra M Johnstone
    Division of Obesity and Metabolic Health and Biomathematics and Statistics Scotland, Rowett Research Institute, Aberdeen, United Kingdom
    Am J Clin Nutr 87:44-55. 2008
    ..Altering the macronutrient composition of the diet influences hunger and satiety. Studies have compared high- and low-protein diets, but there are few data on carbohydrate content and ketosis on motivation to eat and ad libitum intake...
  45. ncbi Orexin and leptin are associated with nicotine craving: a link between smoking, appetite and reward
    Christoph von der Goltz
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health CIMH, Square J5, 68159 Mannheim, Germany
    Psychoneuroendocrinology 35:570-7. 2010
    ..The aim of this study was to examine the possible association between orexin and leptin, and nicotine craving in smokers in a clinical case-control study under standardized conditions...
  46. ncbi Gemini: a UK twin birth cohort with a focus on early childhood weight trajectories, appetite and the family environment
    Cornelia H M van Jaarsveld
    Health Behavior Research Centre, Department of Epidemiology and Public Health, University College London, United Kingdom
    Twin Res Hum Genet 13:72-8. 2010
    ..to assess genetic and environmental influences on early childhood weight trajectories with a focus on infant appetite and the family environment...
  47. ncbi Orexin signaling in the ventral tegmental area is required for high-fat appetite induced by opioid stimulation of the nucleus accumbens
    Huiyuan Zheng
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    J Neurosci 27:11075-82. 2007
    ..pathways and mechanisms responsible for crosstalk between the "cognitive" and "metabolic" brain in the control of appetite. Here we show that neural connections between the nucleus accumbens and hypothalamus might be part of this link...
  48. pmc AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistance
    Nicolas Dzamko
    Department of Medicine, St Vincent s Institute of Medical Research, University of Melbourne, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
    J Biol Chem 285:115-22. 2010
    The AMP-activated protein kinase (AMPK) is an alphabetagamma heterotrimer that regulates appetite and fuel metabolism...
  49. ncbi Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers
    Catherine B Lawrence
    University of Manchester School of Biological Sciences, Oxford Road, Manchester, United Kingdom M13 9PT
    Endocrinology 143:155-62. 2002
    ..Finally, double immunohistochemistry indicated that orexin-containing, but not melanin-concentrating hormone-containing, neurons in the lateral hypothalamus were activated significantly by central administration of GHRP-6...
  50. ncbi Effect of satiety on brain activation during chocolate tasting in men and women
    Paul A M Smeets
    Image Sciences Institute and the Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands
    Am J Clin Nutr 83:1297-305. 2006
    ..A key factor controlling food intake is selective satiety, ie, the phenomenon that the motivation to eat more of a food decreases more than does the motivation to eat foods not eaten...
  51. ncbi Acute effect of oatmeal on subjective measures of appetite and satiety compared to a ready-to-eat breakfast cereal: a randomized crossover trial
    Candida J Rebello
    a Louisiana State University, Baton Rouge, Louisiana
    J Am Coll Nutr 32:272-9. 2013
    ..The objective of this study was to compare the satiety impact of oatmeal with the most widely sold ready-to-eat breakfast cereal (RTEC) when either was consumed as a breakfast meal...
  52. pmc Appetite enhancement and weight gain by peripheral administration of TrkB agonists in non-human primates
    John C Lin
    Rinat, Pfizer Inc, South San Francisco, California, United States of America
    PLoS ONE 3:e1900. 2008
    ..primates TrkB agonists were anorexigenic when applied centrally, but surprisingly orexigenic, leading to gain in appetite, body weight, fat deposits and serum leptin levels, when given peripherally...
  53. pmc The impact of food viscosity on eating rate, subjective appetite, glycemic response and gastric emptying rate
    Yong Zhu
    Department of Food Science and Human Nutrition, Iowa State University, Ames, Iowa, USA
    PLoS ONE 8:e67482. 2013
    Understanding the impact of rheological properties of food on postprandial appetite and glycemic response helps to design novel functional products...
  54. pmc Role of gut nutrient sensing in stimulating appetite and conditioning food preferences
    Anthony Sclafani
    Department of Psychology, Brooklyn College, City University of New York, Brooklyn, NY 11210, USA
    Am J Physiol Regul Integr Comp Physiol 302:R1119-33. 2012
    ..Whereas oral sugar, fat, and umami taste receptors stimulate nutrient appetite, these and other chemosensors in the gut have been linked to digestive, metabolic, and satiating effects that ..
  55. ncbi Sip size of orangeade: effects on intake and sensory-specific satiation
    Pascalle L G Weijzen
    Wageningen University, The Netherlands
    Br J Nutr 102:1091-7. 2009
    ..This suggests that intake of sweet drinks is stimulated by (metabolic) reward value and inhibited by sensory satiation. This underpins the importance of SSS for meal termination...
  56. pmc Impact of treating dental caries on schoolchildren's anthropometric, dental, satisfaction and appetite outcomes: a randomized controlled trial
    Heba A Alkarimi
    King Fahad Armed Forces Hospital, PO Box 54146, Jeddah 21514, Saudi Arabia
    BMC Public Health 12:706. 2012
    ..was conducted to assess the impact of dental treatment of severe dental caries on children's weight, height and subjective health related outcomes, namely dental pain, satisfaction with teeth and smile, dental sepsis and child's appetite.
  57. ncbi Appetite at "high altitude" [Operation Everest III (Comex-'97)]: a simulated ascent of Mount Everest
    M S Westerterp-Plantenga
    Maastricht University, Maastricht, The Netherlands
    J Appl Physiol (1985) 87:391-9. 1999
    ..Therefore we assessed the effect of long-term hypobaric hypoxia per se on appetite in eight men who were exposed to a 31-day simulated stay at several altitudes up to the peak of Mt...
  58. ncbi Inverse association between the effect of carbohydrates on blood glucose and subsequent short-term food intake in young men
    G Harvey Anderson
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ontario, Canada
    Am J Clin Nutr 76:1023-30. 2002
    ..A primary mechanism by which carbohydrates are thought to regulate satiety and food intake is through their effect on blood glucose...
  59. ncbi CNS regulation of appetite
    Joanne A Harrold
    Human Ingestive Behaviour Laboratory, Department of Experimental Psychology, University of Liverpool, Eleanor Rathbone Building, Bedford Street South, Liverpool L69 7ZA, UK
    Neuropharmacology 63:3-17. 2012
    This article reviews the regulation of appetite from a biopsychological perspective...
  60. ncbi Effects of a single dose of exenatide on appetite, gut hormones, and glucose homeostasis in adults with Prader-Willi syndrome
    Lisa Sze
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney Darlinghurst, New South Wales 2010, Australia
    J Clin Endocrinol Metab 96:E1314-9. 2011
    ..Exenatide, recently developed for treatment of type 2 diabetes, induces appetite suppression and weight loss with common side effects.
  61. ncbi 'Expected satiety' changes hunger and fullness in the inter-meal interval
    Jeffrey M Brunstrom
    Department of Experimental Psychology, University of Bristol, 12a Priory Road, Bristol BS8 1TU, United Kingdom
    Appetite 56:310-5. 2011
    ..Participants then assessed the expected satiety of the smoothie and provided appetite ratings, before, and for three hours after its consumption...
  62. pmc Relation of reward from food intake and anticipated food intake to obesity: a functional magnetic resonance imaging study
    Eric Stice
    Oregon Research Institute, 1715 Franklin Boulevard, Eugene, OR 97403, USA
    J Abnorm Psychol 117:924-35. 2008
    ....
  63. ncbi AMPK and the neuroendocrine regulation of appetite and energy expenditure
    Romana Stark
    Department of Physiology, Monash University, Clayton, Victoria, Australia
    Mol Cell Endocrinol 366:215-23. 2013
    This review highlights recent advances in the hormonal control of hypothalamic AMPK activity and the impact on appetite and energy metabolism...
  64. ncbi Both longer oral sensory exposure to and higher intensity of saltiness decrease ad libitum food intake in healthy normal-weight men
    Dieuwerke P Bolhuis
    Product Design and Quality Management Group, Wageningen University, Wageningen, The Netherlands
    J Nutr 141:2242-8. 2011
    ..05). Longer orosensory exposure and higher saltiness intensity both decreased food intake, although orosensory exposure had more impact than intensity. Prolonging the orosensory exposure per food unit may be helpful to reduce food intake...
  65. ncbi Effects of concord grape juice on appetite, diet, body weight, lipid profile, and antioxidant status of adults
    James H Hollis
    Department of Foods and Nutrition, Purdue University, 212 Stone Hall, 700 W State Street, West Lafayette, IN 47907 2059, USA
    J Am Coll Nutr 28:574-82. 2009
    ..This study assessed the effects of CGJ consumption for 12 weeks on appetite, diet, body weight, lipid profile, and antioxidant status.
  66. ncbi Exercise, appetite and weight management: understanding the compensatory responses in eating behaviour and how they contribute to variability in exercise-induced weight loss
    N A King
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane 4059, Australia
    Br J Sports Med 46:315-22. 2012
    ..psychological and behavioural factors potentially involved in the relationship between exercise and appetite, and identify the research questions that remain unanswered...
  67. ncbi Cephalic phase responses and appetite
    Paul A M Smeets
    Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    Nutr Rev 68:643-55. 2010
    ..CPRs could be affected by inconsistencies in the associations between sensory signals and subsequent post-ingestive consequences. Reviewed here are the available data on how CPRs affect the control of food intake...
  68. ncbi Leptin regulates appetite-related neuropeptides in the hypothalamus of developing rats without affecting food intake
    Karine Proulx
    McGill University, Department of Psychiatry, Douglas Hospital Research Center, Montreal, Quebec, Canada H4H 1R3
    Endocrinology 143:4683-92. 2002
    ..We determined whether two appetite-related neuropeptides [neuropeptide Y (NPY) and proopiomelanocortin (POMC)] and food intake behavior are ..
  69. ncbi Exercise, appetite and appetite-regulating hormones: implications for food intake and weight control
    David Stensel
    School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK
    Ann Nutr Metab 57:36-42. 2010
    Knowledge about the relationship between exercise and appetite is important both for athletes wishing to optimise performance and for those interested in maintaining a healthy body weight...
  70. ncbi Affect modulates appetite-related brain activity to images of food
    William D S Killgore
    Cognitive Neuroimaging Laboratory, McLean Hospital, Belmont, Massachusetts, USA
    Int J Eat Disord 39:357-63. 2006
    ..We examined whether affect ratings predicted regional cerebral responses to high and low-calorie foods...
  71. ncbi Effects of oligofructose on appetite profile, glucagon-like peptide 1 and peptide YY3-36 concentrations and energy intake
    Sanne P M Verhoef
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, The Netherlands
    Br J Nutr 106:1757-62. 2011
    ..The present study aimed to examine the effect of oligofructose supplementation on appetite profiles, satiety hormone concentrations and energy intake in human subjects...
  72. pmc Early origins of obesity: programming the appetite regulatory system
    I Caroline McMillen
    Discipline of Physiology, Centre for the Early Origins of Adult Health, School of Molecular and Biomedical Sciences, University of Adelaide, SA 5005, Australia
    J Physiol 565:9-17. 2005
    ..evidence that changes in perinatal nutrition programme the development of relative fat mass and the regulation of appetite in adult life...
  73. ncbi Sustained appetite improvement in malnourished dialysis patients by daily ghrelin treatment
    Damien R Ashby
    Department of Investigative Medicine, Imperial College London, London, UK
    Kidney Int 76:199-206. 2009
    ..and mortality, but neither enteral nor parenteral supplementation provide long-term benefit because of the strong appetite suppression seen in such patients...
  74. ncbi Dopamine transporter gene (DAT1) associated with appetite suppression to methylphenidate in a case-control study of binge eating disorder
    Caroline Davis
    Department of Kinesiology and Health Sciences, York University, Toronto, ON, Canada
    Neuropsychopharmacology 32:2199-206. 2007
    ..study used a double blind, crossover (methylphenidate vs placebo) design to assess DAT1 genotype differences on appetite ratings to a snack-food cue in subjects with binge eating disorder (BED) (n=32) and healthy age-matched controls (..
  75. pmc Short-term effects of liraglutide on visceral fat adiposity, appetite, and food preference: a pilot study of obese Japanese patients with type 2 diabetes
    Kana Inoue
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Yamada oka, Suita, Japan
    Cardiovasc Diabetol 10:109. 2011
    To examine the effects of liraglutide, a glucagon-like peptide-1 (GLP-1) analogue, on visceral fat adiposity, appetite, food preference, and biomarkers of cardiovascular system in Japanese patients with type 2 diabetes.
  76. ncbi Effect of viscosity on appetite and gastro-intestinal hormones
    Nicolien Zijlstra
    Top Institute Food and Nutrition, Wageningen, The Netherlands Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Physiol Behav 97:68-75. 2009
    ..Before intake and 15, 30, 60 and 90 min thereafter, appetite was rated and blood was drawn to determine glucose, CCK-8, active ghrelin, desacyl ghrelin and GLP-1 ..
  77. ncbi Effects of oral ingestion of sucralose on gut hormone response and appetite in healthy normal-weight subjects
    H E Ford
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Hammersmith Campus, Imperial College London, London, UK
    Eur J Clin Nutr 65:508-13. 2011
    ..We conducted a randomised, single-blinded, crossover study in eight healthy subjects to investigate whether oral ingestion of sucralose could stimulate L-cell-derived GLP-1 and peptide YY (PYY) release in vivo...
  78. ncbi Incomplete restoration of the secretion of ghrelin and PYY compared to insulin after food ingestion following weight gain in anorexia nervosa
    Toshihiro Nakahara
    Department of Behavioral Medicine, Kagoshima University, Graduate School of Medical and Dental Sciences, 8 35 1, Sakuragaoka, Kagoshima City 890 8520, Japan
    J Psychiatr Res 41:814-20. 2007
    In humans, ghrelin has been found to stimulate appetite while PYY3-36 to reduce it; these orexigenic and anorexigenic peptides play significant roles in appetite control...
  79. pmc Selective reduction in neural responses to high calorie foods following gastric bypass surgery
    Christopher N Ochner
    New York Obesity Research Center, St Luke s Roosevelt Hospital, New York, NY, USA
    Ann Surg 253:502-7. 2011
    ..To investigate changes in neural activation and desire to eat in response to appetitive cues from pre- to postbariatric surgery for obesity...
  80. ncbi Changes in gut hormone and glucose concentrations in relation to hunger and fullness
    Sofie G Lemmens
    Top Institute Food and Nutrition, Wageningen, Netherlands
    Am J Clin Nutr 94:717-25. 2011
    The search for biomarkers of appetite is very active.
  81. pmc Leptin does not directly affect CNS serotonin neurons to influence appetite
    Daniel D Lam
    Department of Pharmacology, University of Cambridge, UK
    Cell Metab 13:584-91. 2011
    ..Here we investigated mechanisms by which leptin might interact with CNS 5-HT pathways to influence appetite. Although some leptin receptor (LepRb) neurons lie close to 5-HT neurons in the dorsal raphe (DR), 5-HT neurons ..
  82. ncbi Hormonal appetite control is altered by shift work: a preliminary study
    Cibele Aparecida Crispim
    Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Metabolism 60:1726-35. 2011
    ..the study was to evaluate the daily concentrations of leptin, nonacylated ghrelin, and acylated ghrelin and the appetite ratings in men working different shift schedules...
  83. ncbi Short-term sleep loss decreases physical activity under free-living conditions but does not increase food intake under time-deprived laboratory conditions in healthy men
    Sebastian M Schmid
    Departments of Internal Medicine I, the University of Luebeck, Luebeck, Germany
    Am J Clin Nutr 90:1476-82. 2009
    ..Short sleep duration is correlated with an increased risk of developing obesity and cardiovascular disease, but the mechanisms behind this relation are largely unknown...
  84. pmc The putative satiety hormone PYY is raised in cardiac cachexia associated with primary pulmonary hypertension
    C W le Roux
    Heart 91:241-2. 2005
  85. pmc Why does the giant panda eat bamboo? A comparative analysis of appetite-reward-related genes among mammals
    Ke Jin
    School of Life Sciences, Fudan University, Shanghai, China
    PLoS ONE 6:e22602. 2011
    ..However, as this gene is preserved in herbivores such as cow and horse, we need to look for other reasons behind the giant panda's diet switch...
  86. pmc Power of food moderates food craving, perceived control, and brain networks following a short-term post-absorptive state in older adults
    W Jack Rejeski
    Department of Health and Exercise Science and Geriatric Medicine, Wake Forest University, P O Box 7868, Winston Salem, NC 27109, USA
    Appetite 58:806-13. 2012
    ..Future research is needed to examine the eating behavior of persons who score high on the PFS and to develop interventions that directly target food cravings...
  87. ncbi Repeated administration of ghrelin to patients with functional dyspepsia: its effects on food intake and appetite
    Takashi Akamizu
    Ghrelin Research Project, School of Health Sciences, Faculty of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Eur J Endocrinol 158:491-8. 2008
    ..Ghrelin plays a major role in the regulation of food intake (FI), which makes it a strong candidate for the treatment of anorexia...
  88. ncbi Maternal overnutrition impacts offspring adiposity and brain appetite markers-modulation by postweaning diet
    S Rajia
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia
    J Neuroendocrinol 22:905-14. 2010
    ..that even mild maternal overnutrition (CS) led to increased adiposity, glucose intolerance and altered brain appetite regulators in offspring. A greater impact of HFD-induced maternal obesity was evident...
  89. ncbi The use of visual analogue scales to assess motivation to eat in human subjects: a review of their reliability and validity with an evaluation of new hand-held computerized systems for temporal tracking of appetite ratings
    R J Stubbs
    Rowett Research Institute, Bucksburn, Aberdeen, UK
    Br J Nutr 84:405-15. 2000
    ..New hand-held electronic appetite rating systems (EARS) have been developed to increase reliability of data capture and decrease investigator ..
  90. ncbi Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ
    Akio Inui
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    FASEB J 18:439-56. 2004
    ..In addition to its ability to stimulate GH secretion and gastric motility, ghrelin stimulates appetite and induces a positive energy balance leading to body weight gain...
  91. ncbi The corticotropin-releasing factor system as a mediator of the appetite-suppressing effects of stress in fish
    Nicholas J Bernier
    Department of Integrative Biology, University of Guelph, Ont, Canada N1G 2W1
    Gen Comp Endocrinol 146:45-55. 2006
    A characteristic feature of the behavioural response to intensely acute or chronic stressors is a reduction in appetite. In fish, as in other vertebrates, the corticotropin-releasing factor (CRF) system plays a key role in coordinating ..
  92. ncbi NPY and cohorts in regulating appetite, obesity and metabolic syndrome: beneficial effects of gene therapy
    S P Kalra
    Department of Neuroscience, University of Florida, McKnight Brain Institute, PO Box 100244, Gainesville, FL 32610, USA
    Neuropeptides 38:201-11. 2004
    Neuropeptide Y is the most potent physiological appetite transducer known. The NPY network is the conductor of the hypothalamic appetite regulating orchestra in the arcuate nucleus-paraventricular nucleus (ARC-PVN) of the hypothalamus...
  93. ncbi Decreased plasma leptin concentrations in tuberculosis patients are associated with wasting and inflammation
    Reinout van Crevel
    Department of Internal Medicine, University Medical Center Nijmegen, 6500 HB Nijmegen, The Netherlands
    J Clin Endocrinol Metab 87:758-63. 2002
    ..In an urban clinic in Indonesia, plasma leptin concentrations, indicators of adipocyte mass, appetite, C-reactive protein (CRP), tuberculin reactivity, and cytokine response were measured in tuberculosis patients ..
  94. ncbi Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss
    William P Esler
    Bayer Research Center, Bayer HealthCare, West Haven, CT 06516, USA
    Endocrinology 148:5175-85. 2007
    ..GH secretagogue receptor type 1a (GHS-R1a), exerts a variety of metabolic functions including stimulation of appetite and weight gain and suppression of insulin secretion...
  95. ncbi Appetite and inflammation, nutrition, anemia, and clinical outcome in hemodialysis patients
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Harbor University of California, Los Angeles Medical Center, Harbor Mailbox 406, 1000 West Carson Street, Torrance, CA 90509 2910, USA
    Am J Clin Nutr 80:299-307. 2004
    ..Malnutrition-inflammation complex syndrome, an outcome predictor in maintenance hemodialysis (MHD) patients, may be related to anorexia...
  96. ncbi Pancreatic polypeptide reduces appetite and food intake in humans
    R L Batterham
    Department of Metabolic Medicine, Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Road, London W12 0NN, United Kingdom
    J Clin Endocrinol Metab 88:3989-92. 2003
    ..Therefore we investigated the effect of intravenous infusion of PP (10 pmol/kg/min) on appetite and food intake in a randomised double-blind placebo-controlled crossover study in ten healthy volunteers...
  97. ncbi Effect of fat-free potato chips with and without nutrition labels on fat and energy intakes
    D L Miller
    The Pennsylvania State University, Nutrition Department, University Park 16802 6501, USA
    Am J Clin Nutr 68:282-90. 1998
    ..This study showed that substituting fat-free (olestra-containing) potato chips for regular-fat chips can help reduce fat and energy intakes in short-term (within meal) situations and reduce fat intake over 24 h...
  98. ncbi Chronic vagus nerve stimulation decreased weight gain, food consumption and sweet craving in adult obese minipigs
    D Val-Laillet
    INRA, UMR1079 SENAH, Domaine de la Prise, Saint Gilles, France
    Appetite 55:245-52. 2010
    ..Our results showed that chronic VNS decreased weight gain, food consumption and sweet craving in adult obese minipigs, which indicates that this therapy might be used to decrease appetite in the context of morbid obesity.
  99. ncbi Endogenous opioids and cannabinoids: system interactions in the regulation of appetite, grooming and scratching
    A J Tallett
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds LS29JT, UK
    Physiol Behav 94:422-31. 2008
    ..evidence suggests substantial crosstalk between endogenous opioid and cannabinoid systems in the regulation of appetite. Not only is cannabinoid-induced hyperphagia abolished by opioid receptor antagonists (and vice versa), but ..
  100. ncbi Olfactory stimulation with scent of grapefruit oil affects autonomic nerves, lipolysis and appetite in rats
    Jiao Shen
    Division of Protein Metabolism, Institute for Protein Research, Osaka University, 3 2 Yamada Oka, Suita, Osaka 565 0871, Japan
    Neurosci Lett 380:289-94. 2005
    ..Thus, the scent of grapefruit oil, and particularly its primary component limonene, affects autonomic nerves, enhances lipolysis through a histaminergic response, and reduces appetite and body weight.
  101. ncbi Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons
    Marcelo O Dietrich
    Program in Integrative Cell Signalling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Rev Drug Discov 11:675-91. 2012
    Current anti-obesity drugs aim to reduce food intake by either curbing appetite or suppressing the craving for food...

Research Grants72

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  3. Brain Activation responses in adolescents with genetic predisposition to obesity
    Susan Carnell; Fiscal Year: 2011
    ..a specialization in the interaction of genetic, neural and environmental factors to influence children's appetite and weight...
  4. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2012
    ..It has been known for thousands of years that cannabis extracts increase appetite, particularly for highly palatable foods and can result in weight gain...
  5. The gastric X/A-like (ghrelin) cell: A peripheral regulator of food intake
    NILS WG LAMBRECHT; Fiscal Year: 2012
    ..b>Appetite control is vital in body weight regulation and is controlled centrally and peripherally...
  6. Neurobehavioral Correlates of Familial/genetic obesity risk in adolescents
    Susan Carnell; Fiscal Year: 2013
    ..a specialization in the interaction of genetic, neural and environmental factors to influence children's appetite and weight...
  7. Impact of the P479L Variant in CPT1A on Infant Mortality in Alaska
    David M Koeller; Fiscal Year: 2011
    ..Alterations of energy metabolism resulting from dysregulation of CPT1 affects insulin sensitivity, appetite regulation, and a growing list of other critical functions that are tied to fatty acid metabolism...
  8. Mechanisms of action of ghrelin in muscle and adipose tissue in cancer-related ca
    Jose M Garcia; Fiscal Year: 2013
    ..Currently there is no effective way to treat cachexia. The novel hormone ghrelin increases appetite and body weight...
  9. PUFA Synthesis and the Control of Hepatic Metabolism
    Donald B Jump; Fiscal Year: 2013
    ..fat diet-induced hyperglycemia, insulin resistance, and fatty liver in 4 days without changing body weight or appetite. The mechanism for the control of blood glucose was linked to the suppression of hepatic nuclear content of ..
  10. Comparative Effectiveness of Medical Therapy vs. Bariatric Surgery for Obese T2DM
    DAVID BRADLEY contact LAUTZ; Fiscal Year: 2010
    ..Differences may be due to mild malabsorption or alterations in gut peptides that regulate appetite and facilitate sustained weight loss, and/or to changes in incretins that may improve [unreadable]-cell function ..
  11. PKC delta and cell renewal in irradiated taste epithelium
    MARY ELAINE REYLAND; Fiscal Year: 2012
    ..Importantly, patients with reduced taste sensation tend to lack appetite and eat far less, leading to weight loss, as well as a significantly compromised quality of life...
  12. Role of G-gamma-7 in striatal cannabinoid and D2 dopamine
    Dana E Selley; Fiscal Year: 2010
    ..component of the endogenous cannabinoid system, which is involved in motivation and reward, motor control, appetite, learning and memory, and pain and thermoregulation...
  13. Maternal Hyperinsulinemia and Fetal Programming
    Mulchand S Patel; Fiscal Year: 2011
    ..The hypothalamic melanocortin system is considered to play a critical role in the regulation of appetite and body weight homeostasis;it is hypothesized that aberrations in this system contribute significantly towards ..
  14. PROTRH GENE TRANSCRIPTION AND BIOSYNTHESIS BY LEPTIN
    EDUARDO NILLNI; Fiscal Year: 2009
    ..Hormones that regulate energy balance can be categorized into those that influence appetite and those that act to maintain body fat stores...
  15. Appetite-regulating Hormones and Neurocircuitry in Anorexia Nervosa
    ELIZABETH AUSTEN LAWSON; Fiscal Year: 2013
    ..takes a novel, multidisciplinary approach to understanding endocrine factors and neurocircuitry underlying appetite and eating behavior in anorexia nervosa (AN)...
  16. The Role of Estradiol and Sex in the Effects of Ghrelin on Meal Patterns and Fos-
    PETER BUTERA; Fiscal Year: 2009
    ..on food intake and meal patterns in female and male rats and evaluate the ability of estrogen to modulate the appetite-stimulating effects of ghrelin...
  17. Extending Sleep in Obese Adults to Promote Weight Loss
    Ann E Rogers; Fiscal Year: 2010
    ..In addition, well-controlled laboratory studies have documented that sleep loss appears to up-regulate appetite by altering the ability of metabolic hormones to accurately signal caloric need, alters glucose metabolism and ..
  18. Transcriptional regulation of enteroendocrine cell differentiation by NeuroD
    Andrew B Leiter; Fiscal Year: 2013
    ..the total number of epithelial cells but secrete hormones that control numerous physiological processes including appetite and satiety, insulin secretion, and digestive organ function...
  19. Sex Differences in the Cannabioid Regulation of Energy Homeostasis
    Edward J Wagner; Fiscal Year: 2013
    ..The overall goal of this proposal is to gain a better understanding of the cannabinoid regulation of appetite, core body temperature, metabolism, and the cellular mechanism(s) by which they affect the excitability of ..
  20. Functional Selection of Novel Ligands from the Neuroendocrine Secretome
    David Larocca; Fiscal Year: 2010
    ..perception of its environment with its regulation of body functions such as temperature, blood pressure, appetite, digestion, and sleep...
  21. Maternal Dietary Patterns and Child Weight Status
    Chantel L Martin; Fiscal Year: 2013
    ..to acquire an appreciation of the physiology of obesity, endocrinology, and neuroendocrinology in regulation of appetite and energy balance, and the role nutrition has in these processes;(2) to expand knowledge and skills to develop ..
  22. CB1 Receptor Regulation by Cannabinoid Receptor Interacting Protein CRIP1a
    DANA E contact SELLEY; Fiscal Year: 2010
    ..This system is important in the regulation of appetite, pain perception, memory, movement and coordination, and seems to play a role in the rewarding effects of several ..
  23. Neurochemistry/physiology of proopiomelanocortin neurons
    MALCOLM JAMES LOW; Fiscal Year: 2013
    ..the brain's feeding circuits, propiomelanocortin neurons, to explain how these neurons coordinately regulate appetite, meal initiation and termination, and metabolic rate to normally maintain body weight within tightly controlled ..
  24. New Approaches to the Evaluation and Treatment of Acromegaly
    Pamela U Freda; Fiscal Year: 2013
    ..aims, funded by my R01 DK064720, test how the lipodystrophy and its recovery affect AT inflammation, adipokines, appetite hormones, endothelial function, cv risk markers and long-term outcome in acromegaly...
  25. Molecular Control of Brown Adipose Cell Fate and Energy Metabolism
    Shingo Kajimura; Fiscal Year: 2013
    ..Currently, most anti- obesity medications act to repress energy intake, either by suppressing appetite or by inhibiting intestinal fat absorption...
  26. Neural basis of learned food aversion and nausea
    CHARLES HORN; Fiscal Year: 2009
    Some medications produce nausea and vomiting that may lead to loss of appetite and reduced food intake, which can negatively affect recovery from disease...
  27. Mechanisms of Programmed Gestational Hyperphagia
    MICHAEL GLENN ROSS; Fiscal Year: 2012
    ..laboratory model human obesity programming, as IUGR offspring of nutrient- restricted rat dams exhibit increased appetite, weight gain and the development of obesity...
  28. Gastointestinal Hormone Research Core Center
    Chung Owyang; Fiscal Year: 2013
    ..These include 1) Neurobiology in Appetite Control and Visceral Pain, 2) Molecular and Cellular Mechanisms of Inflammation, and 3) Cell Growth ..
  29. RNA editing in a transgenic mouse model of behavioral despair and anxiety.
    Minati Singh; Fiscal Year: 2010
    ..Mice lacking 5HT2CR show signs of stress response, hyperactivity, increased appetite and obesity...
  30. Endocannabinoid Discrimination
    Jenny L Wiley; Fiscal Year: 2013
    ..The system plays an important modulatory role in many crucial CNS processes (e.g., brain reward, appetite regulation, cognition)...
  31. Endocannabinoid Intracellular Transporters
    Dale G Deutsch; Fiscal Year: 2010
    ..target drug target may lead to treatment for addiction, mood disorders, pain and inflammation, cognition, and appetite regulation...
  32. Hypothalamic Deep Brain Stimulation for Morbid Obesity:Development of a Pig Model
    William P Melega; Fiscal Year: 2010
    ..Recent studies of appetite regulatory networks, primarily in rodents, have established that targeted electrical stimulation of ventromedial (..
  33. The Biosynthesis of Anandamide
    Dale G Deutsch; Fiscal Year: 2010
    ..Since anandamide is involved in such diverse functions as reinforcement, mood, memory, appetite, pain and movement, understanding how it is synthesized may lead to treatment for drug addiction, depression, ..
  34. BMP7 and the regulation of central and peripheral energy balance
    Kristy Townsend; Fiscal Year: 2012
    ..Body weight regulation is maintained through a balance of energy intake versus energy expenditure, and targeting appetite or metabolic pathways via obesity therapeutics is a current goal in obesity research...
  35. Melanocortin Signaling in Depression
    Michael Lutter; Fiscal Year: 2013
    ..Disruptions in appetite and body weight regulation are among the most important concerns to patients with mood disorders...
  36. CONNECTIONS OF THE LIMBIC SYSTEM AND HYPOTHALAMUS
    Larry W Swanson; Fiscal Year: 2012
    ..cell type analysis, starting with certain lateral hypothalamic regions apparently involved critically in food appetite regulation;and c) to facilitate the entry of neuroanatomical data into neuroinformatics workbenches on the web...
  37. Novel interventions to reduce stress induced non-homeostatic eating
    Barbara A Laraia; Fiscal Year: 2012
    ..Our translational approach draws from the psychology of eating and behavior change, and neuroscience of stress, appetite and reward, to test whether modulating the reward and stress response systems reduces abdominal obesity and ..
  38. Effects of chronic sleep restriction on energy homeostasis in healthy adults
    ANDREA MARIE SPAETH; Fiscal Year: 2013
    ..examining the effects of sleep loss on energy homeostasis show that reduced sleep is associated with changes in appetite-regulating hormones, daily energy intake (kcals), preference for foods high in carbohydrate content, and timing ..
  39. Changes in neural response to eating after bariatric surgery: MRI results
    Thomas A Wadden; Fiscal Year: 2013
    ..Each of these appetite-regulating hormones has been found to act in brain regions related to both the homeostatic and hedonic control of ..
  40. Catalytic Antibody-Based Vaccine For Weight Loss
    AMANDA LEE GARNER; Fiscal Year: 2010
    ..treatment of weight gain based on the recently discovered hormone, ghrelin, due to its function in stimulating appetite and regulating energy homeostasis...
  41. Drosophila feeding behavior: New tools for the genetic dissection of prandiology
    William W Ja; Fiscal Year: 2012
    ..A better understanding of appetite regulation will lead to better methods for controlling food intake, and therefore to better treatments for food-..
  42. Seasonality of Mood: A Genome-Wide Association Study in the Old Order Amish
    Teodor T Postolache; Fiscal Year: 2010
    ..symptoms with season-specific behavioral changes in photoperiodic mammals (environment disengagement, increased appetite, weight and sleepiness, reduced energy and reproductive drive)24, the effectiveness of timed bright light ..
  43. Do Genotype Patterns Predict Weight Loss Success for Low Carb vs. Low Fat Diets?
    Christopher D Gardner; Fiscal Year: 2013
    ..will occur at 0, 3, 6, and 12 months and include energy intake (3-day unannounced 24-hour recalls, NDS-R), appetite/satiety/hunger, energy expenditure (resting energy expenditure), body composition (DEXA), and blood variables (..
  44. Hypothalamic Mechanisms in Cachexia
    Daniel L Marks; Fiscal Year: 2013
    ..This devastating state of malnutrition is brought about by a synergistic combination of a dramatic decrease in appetite and an increase in metabolism of fat and lean body mass...
  45. NEURONAL CONTROL OF INTERACTIONS AMONG BEHAVIORS
    William B Kristan; Fiscal Year: 2013
    ..has been implicated in almost every conceivable physiologic or behavioral function-affect, aggression, appetite, cognition, emesis, endocrine function, gastrointestinal function, motor function, neurotropism, perception, ..
  46. The Role of the Central Melanocortin System in the Muscle Wasting of Cachexia
    THEODORE PAUL BRAUN; Fiscal Year: 2013
    ..The role of the melanocortin system in appetite and basal metabolic rate is well established, but its role in the regulation of the anabolic/catabolic balance of ..
  47. Modulation of Taste-Related Behavior by Molecular Mediators of Appetite &Satiety
    Cedrick D Dotson; Fiscal Year: 2013
    ..taste research in recent years have realigned our thinking as to how taste perception is linked to mechanisms of appetite and satiety...
  48. BIOLOGY OF NEUROENDOCRINE PEPTIDES
    Marc R Montminy; Fiscal Year: 2013
    ..We continue our focus on stress and several projects are now emphasizing metabolism, namely control of appetite and regulation of insulin secretion and sensitivity...
  49. The role of taste in amino acid appetite
    Ivan E de Araujo; Fiscal Year: 2013
    ..Our work may provide new insights on the exact roles of taste quality and metabolism in sugar overconsumption. ..
  50. Transmucosal Intra-Oral Drug Delivery System for THC
    Mahmoud A ElSohly; Fiscal Year: 2010
    ..Marinol(r) soft gelatin capsules) for the treatment of nausea and vomiting associated with chemotherapy and for appetite stimulation in AIDS patients suffering from the wasting syndrome...
  51. Central neural function of Urocortin 3 in regulating energy balance
    Chien Li; Fiscal Year: 2013
    ..Urocortin 3 (Ucn 3) is a new neuropeptide identified in rodents and humans with strong central appetite suppressive effect. Ucn 3 expressing neurons heavily innervate the ventromedial hypothalamus (VMH)...
  52. Mechanisms of Cancer Treatment Related Symptoms
    Lisa J Wood; Fiscal Year: 2013
    ..often experience a constellation of cancer treatment related symptoms (CTRS) which includes malaise, decreased appetite, sleep disturbance, difficulty thinking, anemia, pain, depressed mood and changes in body composition...
  53. Neural mechanisms underlying abnormal food reward processing in depressed women
    LAURA MCGRATH HOLSEN; Fiscal Year: 2013
    ..relationships between brain activation in subcortical regions of interest and HPA- /HPG-axis hormones and appetite-regulatory peptides in women with MDD and obesity;and 3) test hypotheses regarding associations between MDD ..
  54. Keystone Symposia on Cellular and Molecular Basis of Metabolic Disorders Series
    JAMES WAVELL AIKEN; Fiscal Year: 2013
    ..The concurrent Neuronal Control of Appetite, Metabolism and Weight meeting addresses the crucial need for deeper understanding of the complex mechanisms of ..
  55. Motivational Changes for Nutritionally Relevant Tastes after Gastric Bypass
    Alan C Spector; Fiscal Year: 2013
    ..average, 25% of their body weight postoperatively for the long term, and this is accompanied by an attenuation of appetite leading to decreased caloric intake. Importantly alterations in food selection have been reported...
  56. Cortisol regulation of perinatal adipose tissue and sheep neonatal leptin peak
    Stephen P Ford; Fiscal Year: 2013
    ..Our sheep model of diet-induced maternal obesity (MO) increases adult OFF appetite and adiposity...
  57. A twin study of obesity pathogenesis using fMRI
    Ellen A Schur; Fiscal Year: 2013
    ..This proposal has the potential to advance scientific knowledge of the brain's regulation of appetite and satiety...
  58. Appetite: Serotonin and corticotropin releasing factor
    SuJean Choi; Fiscal Year: 2012
    ..also known that 5-HT terminal projections are found on PVN CRF neurons;this suggests that 5HT agents may suppress appetite through heretofore uncharacterized actions on PVN CRF neurons...
  59. MOLECULAR BASIS OF CHOLESTEROL METABOLISM
    Joseph L Goldstein; Fiscal Year: 2013
    ..attaches octanoic acid to ghrelin, a covalent modification required for ghrelin's activity in controlling appetite and blod sugar;7) identification of a protein, MIG12, that activates fatty acid synthesis in liver;8) discovery ..
  60. PHYSIOLOGY OF CALCIUM APPETITE
    Michael G Tordoff; Fiscal Year: 2013
    ..abstract_text> ..
  61. Endocannabinoid modulation of pain-depressed behavior
    LAURA J SIMSELLEY; Fiscal Year: 2013
    ..The system plays an important modulatory role in many crucial CNS processes (e.g., brain reward, appetite regulation, cognition)...
  62. The Role Leptin on Arousal
    PAIGE B BECK; Fiscal Year: 2013
    ..Leptin is an adipokine that regulates appetite, body weight, and reproduction by way of receptors in the hypothalamus...
  63. DIOXINS AND HYPOTHALAMIC APPETITE NEUROPEPTIDES
    GEORGE GREELEY; Fiscal Year: 2000
    ..We intend to demonstrate that alteration in the homeostasis of neuropeptides or of neuropeptide receptors involved in hypothalamic control of feeding behavior is a mechanism underlying the anorectic action of PCAHs. ..
  64. Inhibition of Endocannabinoid Biosynthesis via Diacylglycerol Lipase
    RICHARD DUCLOS; Fiscal Year: 2009
    ..and the role of this enzyme in endocannabinoid signaling and physiological responses related to appetite, substance abuse, and related health effects...
  65. APPETITE FOCUSED CBWL FOR BINGE EATING DISORDERS
    Linda Craighead; Fiscal Year: 2001
    ..and overeating specifically, and she has developed an intervention based on that model which is centered around appetite monitoring...
  66. SUBCORTICAL MODULATION OF THE DORSAL VAGAL COMPLEX
    Xueguo Zhang; Fiscal Year: 2002
    DESCRIPTION (applicant's abstract): Disorders of appetite and feeding (including anorexia nervosa and bulimia nervosa) can have a profound impact on the quality of life and may even contribute to or cause death...
  67. Neuropeptide Modulation of Taste Signals
    Nirupa Chaudhari; Fiscal Year: 2010
    ..is a potent anorexigenic peptide that plays a key role at hypothalamic and hindbrain centers that regulate appetite, satiety and ingestion. Taste strongly influences food selection...
  68. Neural Mechanisms of Overeating in Prader-Willi Syndrome
    Anastasia Dimitropoulos; Fiscal Year: 2009
    ..PWS is characterized by an insatiable appetite associated with excessive overeating, propensity to obesity, food preoccupations, food foraging, and compulsivity...
  69. Forebrain Response to Sapid NaCI During Salt Appetite
    Samantha Dayawansa; Fiscal Year: 2009
    ..Salt appetite is a biological drive triggered by a negative body sodium balance...
  70. Screening Method for GPCRs Related to Appetite
    MARIA MORANO; Fiscal Year: 2009
    ..drug compounds from combinatorial libraries that target G-Protein-Coupled Receptors (GPCR's) associated with appetite control and eating behavior...
  71. INTEGRATING ENERGY STORAGE, HIPPOCAMPUS AND HORMONES
    JEFFREY LUCAS; Fiscal Year: 2002
    ..Seasonal Affective Disorder (SAD) is a seasonal pattern of clinical depression that also correlates with changes in appetite, weight regulation, hormone profiles, and social interactions...
  72. Light Treatment for Winter-SAD: Prediction of Response by Immediate Improvement
    TEODOR POSTOLACHE; Fiscal Year: 2009
    ..SAD symptoms include dysphoria, increased appetite, food intake and weight gain and reduced energy and motivation, which are associated with drastic seasonal ..