psychomotor performance

Summary

Summary: The coordination of a sensory or ideational (cognitive) process and a motor activity.

Top Publications

  1. ncbi Control of goal-directed and stimulus-driven attention in the brain
    Maurizio Corbetta
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Rev Neurosci 3:201-15. 2002
  2. ncbi The role of the medial frontal cortex in cognitive control
    K Richard Ridderinkhof
    Department of Psychology, University of Amsterdam, Roetersstraat 15, 1018 WB Amsterdam, Netherlands
    Science 306:443-7. 2004
  3. ncbi The mirror-neuron system
    Giacomo Rizzolatti
    Dipartimento di Neuroscienze, Sezione di Fisiologia, Via Volturno, 3, Universita di Parma 43100, Parma, Italy
    Annu Rev Neurosci 27:169-92. 2004
  4. pmc Influence of cognitive control and mismatch on the N2 component of the ERP: a review
    Jonathan R Folstein
    Department of Psychology, University of Arizona, Tucson, Arizona, USA
    Psychophysiology 45:152-70. 2008
  5. ncbi The functional role of the parieto-frontal mirror circuit: interpretations and misinterpretations
    Giacomo Rizzolatti
    University of Parma, Department of Neuroscience, and the Italian Institute of Technology, Via Volturno 39, I 43100 Parma, Italy
    Nat Rev Neurosci 11:264-74. 2010
  6. ncbi Motor-sensory recalibration leads to an illusory reversal of action and sensation
    Chess Stetson
    Department of Neurobiology and Anatomy, University of Texas Medical School, 6431 Fannin Street, Suite 7046, Houston, TX 77030, USA
    Neuron 51:651-9. 2006
  7. ncbi Trial-by-trial coupling of concurrent electroencephalogram and functional magnetic resonance imaging identifies the dynamics of performance monitoring
    Stefan Debener
    Institute of Neurophysiology and Pathophysiology, Center of Experimental Medicine, University Medical Center, Hamburg University, D 20246 Hamburg, Germany
    J Neurosci 25:11730-7. 2005
  8. ncbi Effects of non-invasive cortical stimulation on skilled motor function in chronic stroke
    Friedhelm Hummel
    Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20817, USA
    Brain 128:490-9. 2005
  9. ncbi Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans
    Adam R Aron
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge CB2 2QQ, UK
    Nat Neurosci 6:115-6. 2003
  10. ncbi Testing the efficiency and independence of attentional networks
    Jin Fan
    The Sackler Institute for Developmental Psychobiology, Department of Psychiatry, Weill Medical College of Cornell University, 1300 York Avenue, Box 140, New York, NY 10002, USA
    J Cogn Neurosci 14:340-7. 2002

Detail Information

Publications288 found, 100 shown here

  1. ncbi Control of goal-directed and stimulus-driven attention in the brain
    Maurizio Corbetta
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Rev Neurosci 3:201-15. 2002
    ..This ventral frontoparietal network works as a 'circuit breaker' for the dorsal system, directing attention to salient events. Both attentional systems interact during normal vision, and both are disrupted in unilateral spatial neglect...
  2. ncbi The role of the medial frontal cortex in cognitive control
    K Richard Ridderinkhof
    Department of Psychology, University of Amsterdam, Roetersstraat 15, 1018 WB Amsterdam, Netherlands
    Science 306:443-7. 2004
    ....
  3. ncbi The mirror-neuron system
    Giacomo Rizzolatti
    Dipartimento di Neuroscienze, Sezione di Fisiologia, Via Volturno, 3, Universita di Parma 43100, Parma, Italy
    Annu Rev Neurosci 27:169-92. 2004
    ..We stress, in particular, those properties specific to the human mirror-neuron system that might explain the human capacity to learn by imitation. We conclude by discussing the relationship between the mirror-neuron system and language...
  4. pmc Influence of cognitive control and mismatch on the N2 component of the ERP: a review
    Jonathan R Folstein
    Department of Psychology, University of Arizona, Tucson, Arizona, USA
    Psychophysiology 45:152-70. 2008
    ..We focus on the visual modality for which components with frontocentral and more posterior scalp distributions can be readily distinguished...
  5. ncbi The functional role of the parieto-frontal mirror circuit: interpretations and misinterpretations
    Giacomo Rizzolatti
    University of Parma, Department of Neuroscience, and the Italian Institute of Technology, Via Volturno 39, I 43100 Parma, Italy
    Nat Rev Neurosci 11:264-74. 2010
    ....
  6. ncbi Motor-sensory recalibration leads to an illusory reversal of action and sensation
    Chess Stetson
    Department of Neurobiology and Anatomy, University of Texas Medical School, 6431 Fannin Street, Suite 7046, Houston, TX 77030, USA
    Neuron 51:651-9. 2006
    ..This illusion-specific activation suggests that the brain maintains not only a recalibrated representation of timing, but also a less-plastic representation against which to compare it...
  7. ncbi Trial-by-trial coupling of concurrent electroencephalogram and functional magnetic resonance imaging identifies the dynamics of performance monitoring
    Stefan Debener
    Institute of Neurophysiology and Pathophysiology, Center of Experimental Medicine, University Medical Center, Hamburg University, D 20246 Hamburg, Germany
    J Neurosci 25:11730-7. 2005
    ..We conclude that investigations of the dynamic coupling between EEG and fMRI provide a powerful approach for the study of higher order brain functions...
  8. ncbi Effects of non-invasive cortical stimulation on skilled motor function in chronic stroke
    Friedhelm Hummel
    Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20817, USA
    Brain 128:490-9. 2005
    ....
  9. ncbi Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans
    Adam R Aron
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge CB2 2QQ, UK
    Nat Neurosci 6:115-6. 2003
  10. ncbi Testing the efficiency and independence of attentional networks
    Jin Fan
    The Sackler Institute for Developmental Psychobiology, Department of Psychiatry, Weill Medical College of Cornell University, 1300 York Avenue, Box 140, New York, NY 10002, USA
    J Cogn Neurosci 14:340-7. 2002
    ..The ANT may also serve as an activation task for neuroimaging studies and as a phenotype for the study of the influence of genes on attentional networks...
  11. ncbi Resolving emotional conflict: a role for the rostral anterior cingulate cortex in modulating activity in the amygdala
    Amit Etkin
    Center for Neurobiology and Behavior, Columbia University Medical Center, Neurological Institute Box 108, 710 West 168th Street, New York, New York 10032, USA
    Neuron 51:871-82. 2006
    ..These data suggest that emotional conflict is resolved through top-down inhibition of amygdalar activity by the rostral cingulate cortex...
  12. ncbi The neural bases of momentary lapses in attention
    D H Weissman
    Center for Cognitive Neuroscience and Department of Psychiatry, Duke University, Durham, North Carolina 27708, USA
    Nat Neurosci 9:971-8. 2006
    ..Our findings provide a new, system-wide understanding of the patterns of brain activity that are associated with brief attentional lapses, which informs both theoretical and clinical models of goal-directed behavior...
  13. ncbi Recalibration of audiovisual simultaneity
    Waka Fujisaki
    NTT Communication Science Laboratories, NTT Corporation, 3 1 Morinosato Wakamiya, Atsugi, Kanagawa 243 0198, Japan
    Nat Neurosci 7:773-8. 2004
    ..Our findings suggest that the brain attempts to adjust subjective simultaneity across different modalities by detecting and reducing time lags between inputs that likely arise from the same physical events...
  14. ncbi Computational principles of movement neuroscience
    D M Wolpert
    Sobell Department of Neurophysiology, Institute of Neurology, University College London, UK
    Nat Neurosci 3:1212-7. 2000
    ..Our goal is to demonstrate how specific models emerging from the computational approach provide a theoretical framework for movement neuroscience...
  15. pmc States versus rewards: dissociable neural prediction error signals underlying model-based and model-free reinforcement learning
    Jan Gläscher
    Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91101, USA
    Neuron 66:585-95. 2010
    ..This finding supports the existence of two unique forms of learning signal in humans, which may form the basis of distinct computational strategies for guiding behavior...
  16. pmc Optimality principles in sensorimotor control
    Emanuel Todorov
    Department of Cognitive Science, University of California San Diego, La Jolla, California 92093 0515, USA
    Nat Neurosci 7:907-15. 2004
    ..At the heart of the framework is the relationship between high-level goals, and the real-time sensorimotor control strategies most suitable for accomplishing those goals...
  17. ncbi Bayesian integration in sensorimotor learning
    Konrad P Kording
    Sobell Department of Motor Neuroscience, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Nature 427:244-7. 2004
    ..The central nervous system therefore employs probabilistic models during sensorimotor learning...
  18. ncbi Parietal lobe: from action organization to intention understanding
    Leonardo Fogassi
    Dipartimento di Psicologia, Universita di Parma, Borgo Carissimi 10, 43100 Parma, Italy
    Science 308:662-7. 2005
    ..Thus, these neurons not only code the observed motor act but also allow the observer to understand the agent's intentions...
  19. ncbi Neural simulation of action: a unifying mechanism for motor cognition
    M Jeannerod
    Institut des Sciences Cognitives, 67 Boulevard Pinel, Bron, 69675, France
    Neuroimage 14:S103-9. 2001
    ..The function of this process of simulation would be not only to shape the motor system in anticipation to execution, but also to provide the self with information on the feasibility and the meaning of potential actions...
  20. ncbi Action video game modifies visual selective attention
    C Shawn Green
    Department of Brain and Cognitive Sciences, Center for Visual Science, University of Rochester, Rochester, New York 14627, USA
    Nature 423:534-7. 2003
    ..In a fifth experiment, non-players trained on an action video game show marked improvement from their pre-training abilities, thereby establishing the role of playing in this effect...
  21. ncbi Error-related brain potentials are differentially related to awareness of response errors: evidence from an antisaccade task
    S Nieuwenhuis
    Department of Psychonomics, University of Amsterdam, The Netherlands
    Psychophysiology 38:752-60. 2001
    ....
  22. ncbi Effect anticipation and action control
    B Elsner
    Department of Cognition and Action, Max Planck Institute for Psychological Research, Munich, Germany
    J Exp Psychol Hum Percept Perform 27:229-40. 2001
    ..These processes may be basic for the control of voluntary action by the anticipation of action goals...
  23. pmc Effect before cause: supramodal recalibration of sensorimotor timing
    James Heron
    Bradford School of Optometry and Vision Science, University of Bradford, Bradford, United Kingdom
    PLoS ONE 4:e7681. 2009
    ....
  24. ncbi The architecture of cognitive control in the human prefrontal cortex
    Etienne Koechlin
    Institut National de la Sante et de Recherche Medicale, Universite Pierre et Marie Curie, 9, quai St Bernard, 75005 Paris, France
    Science 302:1181-5. 2003
    ..The results support an unified modular model of cognitive control that describes the overall functional organization of the human lateral PFC and has basic methodological and theoretical implications...
  25. ncbi Neurocognitive mechanisms of cognitive control: the role of prefrontal cortex in action selection, response inhibition, performance monitoring, and reward-based learning
    K Richard Ridderinkhof
    Department of Psychology, University of Amsterdam, The Netherlands
    Brain Cogn 56:129-40. 2004
    ..Lateral and orbitofrontal divisions of prefrontal cortex are involved in subsequently implementing appropriate adjustments...
  26. ncbi Action anticipation and motor resonance in elite basketball players
    Salvatore M Aglioti
    Dipartimento di Psicologia, Sapienza Universita di Roma, Via dei Marsi 78, 1 00185, Roma, Italy
    Nat Neurosci 11:1109-16. 2008
    ....
  27. ncbi Understanding others' actions and goals by mirror and mentalizing systems: a meta-analysis
    Frank Van Overwalle
    Vrije Universiteit Brussel, Belgium
    Neuroimage 48:564-84. 2009
    ....
  28. ncbi Computational mechanisms of sensorimotor control
    David W Franklin
    Computational and Biological Learning Laboratory, Department of Engineering, University of Cambridge, UK
    Neuron 72:425-42. 2011
    ..Together, these computational mechanisms allow skilled and fluent sensorimotor behavior...
  29. ncbi The neural basis of decision making
    Joshua I Gold
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6074, USA
    Annu Rev Neurosci 30:535-74. 2007
    ..We focus on simple decisions that can be studied in the laboratory but emphasize general principles likely to extend to other settings...
  30. ncbi Coding and use of tactile signals from the fingertips in object manipulation tasks
    Roland S Johansson
    Physiology Section, Department of Integrative Medical Biology, Umea University, SE 901 87 Umea, Sweden
    Nat Rev Neurosci 10:345-59. 2009
    ..Analysis of signals in tactile afferent neurons and central processes in humans reveals how contact events are encoded and used to monitor and update task performance...
  31. ncbi Event files: feature binding in and across perception and action
    Bernhard Hommel
    Leiden University, Department of Psychology, Cognitive Psychology Unit, Postbus 9555, 2300 RB Leiden, The Netherlands
    Trends Cogn Sci 8:494-500. 2004
    ..These bindings produce systematic but often surprising and counter-intuitive interactions between, and impairments in, perception and action planning...
  32. ncbi Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits
    J D Salamone
    Division of Behavioral Neuroscience, Department of Psychology, University of Connecticut, Storrs, CT, 06269 1020, USA
    Psychopharmacology (Berl) 191:461-82. 2007
    ....
  33. ncbi The emulation theory of representation: motor control, imagery, and perception
    Rick Grush
    Department of Philosophy, University of California, San Diego, La Jolla, CA 92093 0119, USA
    Behav Brain Sci 27:377-96; discussion 396-442. 2004
    ..I close by briefly outlining other cognitive functions that might also be synthesized within this framework, including reasoning, theory of mind phenomena, and language...
  34. ncbi Spike synchronization and rate modulation differentially involved in motor cortical function
    A Riehle
    Center for Research in Cognitive Neuroscience, CNRS, 31 Chemin Joseph Aiguier, 13402 Marseille Cx 20, France
    Science 278:1950-3. 1997
    ..These findings indicate that internally generated synchronization of individual spike discharges may subserve the cortical organization of cognitive motor processes...
  35. ncbi A unifying view of the basis of social cognition
    Vittorio Gallese
    Department of Neuroscience, Section of Physiology, University of Parma, Italy
    Trends Cogn Sci 8:396-403. 2004
    ..A similar mechanism, but involving the activation of viscero-motor centers, underlies the experiential understanding of the emotions of others...
  36. ncbi Transient induced gamma-band response in EEG as a manifestation of miniature saccades
    Shlomit Yuval-Greenberg
    Department of Psychology, The Hebrew University of Jerusalem, Jerusalem 91905, Israel
    Neuron 58:429-41. 2008
    ..Thus, whereas neuronal gamma-band oscillations were shown conclusively with other methods, the broadband transient iGBR recorded by scalp EEG reflects properties of miniature saccade dynamics rather than neuronal oscillations...
  37. ncbi Error correction, sensory prediction, and adaptation in motor control
    Reza Shadmehr
    Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Annu Rev Neurosci 33:89-108. 2010
    ..Forward models are only useful if they produce unbiased predictions. Evidence shows that forward models remain calibrated through motor adaptation: learning driven by sensory prediction errors...
  38. ncbi Fast readout of object identity from macaque inferior temporal cortex
    Chou P Hung
    McGovern Institute for Brain Research, Cambridge, MA 02139, USA
    Science 310:863-6. 2005
    ..This information generalized over a range of object positions and scales, even for novel objects. Coarse information about position and scale could also be read out from the same population...
  39. pmc The phi complex as a neuromarker of human social coordination
    Emmanuelle Tognoli
    Human Brain and Behavior Laboratory, Center for Complex Systems and Brain Sciences, Florida Atlantic University, Boca Raton, FL 33431, USA
    Proc Natl Acad Sci U S A 104:8190-5. 2007
    ..A plausible mechanism is that the phi complex reflects the influence of the other on a person's ongoing behavior, with phi(1) expressing the inhibition of the human mirror neuron system and phi(2) its enhancement...
  40. pmc Beta oscillations in a large-scale sensorimotor cortical network: directional influences revealed by Granger causality
    Andrea Brovelli
    Center for Complex Systems and Brain Sciences, Florida Atlantic University, Boca Raton, FL 33431, USA
    Proc Natl Acad Sci U S A 101:9849-54. 2004
    ....
  41. ncbi Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions
    A Bechara
    Department of Neurology, Division of Behavioral Neurology and Cognitive Neuroscience, University of Iowa College of Medicine, Iowa City, Iowa, USA
    Brain 123:2189-202. 2000
    ..This 'myopia for the future' in VM lesion patients persists in the face of severe adverse consequences, i.e. rising future punishment or declining future reward...
  42. ncbi Sensorimotor synchronization: a review of the tapping literature
    Bruno H Repp
    Haskins Laboratories, New Haven, CT 06511 6624, USA
    Psychon Bull Rev 12:969-92. 2005
    ..They exemplify the general distinction between subconscious mechanisms of action regulation and conscious processes involved in perceptual judgment and action planning...
  43. ncbi The role of motor contagion in the prediction of action
    Sarah Jayne Blakemore
    Institute of Cognitive Neuroscience, 17 Queen Square, London WC1N 3AR, UK
    Neuropsychologia 43:260-7. 2005
    ..We suggest that this crude motor contagion is the first step in a more sophisticated predictive system that allows us to infer goals from the observation of actions...
  44. ncbi Intentional maps in posterior parietal cortex
    Richard A Andersen
    Division of Biology, California Institute of Technology, Mail code 216 76, Pasadena 91125, USA
    Annu Rev Neurosci 25:189-220. 2002
    ..Attention and learning effects are also evident in the PPC. However, these effects may be general to cortex and operate in the PPC in the context of sensory-motor transformations...
  45. ncbi Sensorimotor learning configures the human mirror system
    Caroline Catmur
    Department of Psychology, University College London, London, UK
    Curr Biol 17:1527-31. 2007
    ..Our findings indicate that the human mirror system is, to some extent, both a product and a process of social interaction...
  46. pmc The functional organization of the intraparietal sulcus in humans and monkeys
    Christian Grefkes
    Institute of Medicine, Research Center Julich, Germany
    J Anat 207:3-17. 2005
    ....
  47. ncbi A point process framework for relating neural spiking activity to spiking history, neural ensemble, and extrinsic covariate effects
    Wilson Truccolo
    Neuroscience Department, Brown University, Providence, RI, USA
    J Neurophysiol 93:1074-89. 2005
    ..The framework thus allows for the formulation and analysis of point process models of neural spiking activity that readily capture the simultaneous effects of multiple covariates and enables the assessment of their relative importance...
  48. ncbi From thought to action: the parietal cortex as a bridge between perception, action, and cognition
    Jacqueline Gottlieb
    Center for Neurobiology and Behavior and Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Neuron 53:9-16. 2007
    ..By specifying attentional priority as a synthesis of multiple task demands, LIP operates at the interface of perception, action, and cognition...
  49. ncbi Action plans used in action observation
    J Randall Flanagan
    Department of Psychology and Centre for Neuroscience Studies, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Nature 424:769-71. 2003
    ..These results indicate that during action observation subjects implement eye motor programs directed by motor representations of manual actions and thus provide strong evidence for the direct matching hypothesis...
  50. ncbi Beyond the comparator model: a multifactorial two-step account of agency
    Matthis Synofzik
    Department of Cognitive Neurology, Hertie Institute of Clinical Brain Research, University of Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Conscious Cogn 17:219-39. 2008
    ..Our framework, however, is able to provide a unified account for the sense of agency for both actions and thoughts...
  51. ncbi Intention, action planning, and decision making in parietal-frontal circuits
    Richard A Andersen
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Neuron 63:568-83. 2009
    ....
  52. ncbi Modulation of activity in medial frontal and motor cortices during error observation
    Hein T van Schie
    Nijmegen Institute for Cognition and Information, University of Nijmegen, Box 9104, 6500 HE Nijmegen, The Netherlands
    Nat Neurosci 7:549-54. 2004
    ..These data suggest that similar neural mechanisms are involved in monitoring one's own actions and the actions of others...
  53. pmc High gamma power is phase-locked to theta oscillations in human neocortex
    R T Canolty
    Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA
    Science 313:1626-8. 2006
    ..The results indicate that transient coupling between low- and high-frequency brain rhythms coordinates activity in distributed cortical areas, providing a mechanism for effective communication during cognitive processing in humans...
  54. ncbi The effect of stimulus strength on the speed and accuracy of a perceptual decision
    John Palmer
    Department of Psychology, University of Washington, Seattle, WA, USA
    J Vis 5:376-404. 2005
    ..The theory's analytic chronometric function allows one to extend theories of accuracy to response time...
  55. ncbi Functional magnetic resonance imaging reveals the neural substrates of arm transport and grip formation in reach-to-grasp actions in humans
    Cristiana Cavina-Pratesi
    Department of Psychology, Durham University, Durham DH13LE, United Kingdom
    J Neurosci 30:10306-23. 2010
    ....
  56. ncbi Flexible control of mutual inhibition: a neural model of two-interval discrimination
    Christian K Machens
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Science 307:1121-4. 2005
    ..Mutual inhibition between nonlinear units is a useful design motif for networks that must display multiple behaviors...
  57. ncbi Transcranial direct current stimulation of the unaffected hemisphere in stroke patients
    Felipe Fregni
    Harvard Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Neuroreport 16:1551-5. 2005
    ..These results suggest that the appropriate modulation of bihemispheric brain structures can promote motor function recovery...
  58. pmc Direct control of paralysed muscles by cortical neurons
    Chet T Moritz
    Department of Physiology and Biophysics and Washington National Primate Research Center, University of Washington, Seattle, Washington 98195, USA
    Nature 456:639-42. 2008
    ..These results are the first demonstration that direct artificial connections between cortical cells and muscles can compensate for interrupted physiological pathways and restore volitional control of movement to paralysed limbs...
  59. ncbi N-back working memory paradigm: a meta-analysis of normative functional neuroimaging studies
    Adrian M Owen
    MRC Cognition and Brain Sciences Unit, Cambridge, United Kingdom
    Hum Brain Mapp 25:46-59. 2005
    ....
  60. ncbi Anterior cingulate cortex and conflict detection: an update of theory and data
    Cameron S Carter
    Imaging Research Center, University of California at Davis, Sacramento, California 95817, USA
    Cogn Affect Behav Neurosci 7:367-79. 2007
    ..We also discuss some discrepant results in the literature that highlight the need for future research...
  61. pmc A central source of movement variability
    Mark M Churchland
    Neurosciences Program, Stanford University, Stanford, California 94305, USA
    Neuron 52:1085-96. 2006
    ..Thus, even for a highly practiced task, the ability to repeatedly plan the same movement limits our ability to repeatedly execute the same movement...
  62. pmc Three-dimensional locations and boundaries of motor and premotor cortices as defined by functional brain imaging: a meta-analysis
    Mary A Mayka
    Department of Movement Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuroimage 31:1453-74. 2006
    ..HMAT is available through e-mail from the corresponding author...
  63. ncbi Experiencing oneself vs another person as being the cause of an action: the neural correlates of the experience of agency
    C Farrer
    Institut des Sciences Cognitives, 67 Boulevard Pinel, 69675 Bron Cedex, France
    Neuroimage 15:596-603. 2002
    ..The inferior parietal cortex, in contrast, represents movements in an allocentric coding system that can be applied to the actions of others as well as the self...
  64. ncbi Cumulative sleepiness, mood disturbance, and psychomotor vigilance performance decrements during a week of sleep restricted to 4-5 hours per night
    D F Dinges
    Department of Psychiatry, University of Pennyslvania School of Medicine, Philadelphia 19104-6021, USA
    Sleep 20:267-77. 1997
    ..These findings suggest that cumulative nocturnal sleep debt had a dynamic and escalating analog in cumulative daytime sleepiness and that asymptotic or steady-state sleepiness was not achieved in response to sleep restriction...
  65. pmc Response inhibition in the stop-signal paradigm
    Frederick Verbruggen
    Department of Psychology, Vanderbilt University, Nashville, TN 37203, USA
    Trends Cogn Sci 12:418-24. 2008
    ....
  66. ncbi The image of time: a voxel-wise meta-analysis
    Martin Wiener
    Department of Psychology, University of Pennsylvania, Philadelphia, PA, USA
    Neuroimage 49:1728-40. 2010
    ..These results suggest that the processing of temporal information is mediated by a distributed network that can be differentially engaged depending on the task requirements...
  67. ncbi Imitation: is cognitive neuroscience solving the correspondence problem?
    Marcel Brass
    Department of Cognitive Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstrasse 1a, 04103 Leipzig, Germany
    Trends Cogn Sci 9:489-95. 2005
    ..This imitative capacity depends on learned perceptual-motor links. Finally, mechanisms distinguishing self from other are implicated in the inhibition of imitative behaviour...
  68. ncbi Distinct systems for automatic and cognitively controlled time measurement: evidence from neuroimaging
    Penelope A Lewis
    University Laboratory of Physiology, Parks Road, OX1 3PT, Oxford, UK
    Curr Opin Neurobiol 13:250-5. 2003
    ..The 'automatic' system draws mainly upon motor circuits and the 'cognitively controlled' system depends upon prefrontal and parietal regions...
  69. ncbi Temporal dynamics of brain activation during a working memory task
    J D Cohen
    Department of Psychology, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Nature 386:604-8. 1997
    ..We used the temporal resolution of this technique to examine the dynamics of regional activation, and to show that prefrontal cortex along with parietal cortex appears to play a role in active maintenance...
  70. pmc Motor adaptation as a process of reoptimization
    Jun Izawa
    Laboratory for Computational Motor Control, Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 28:2883-91. 2008
    ..Through reward-based optimization, we use the internal model to search for a better movement plan to minimize implicit motor costs and maximize rewards...
  71. ncbi Cognitive motor interference while walking: a systematic review and meta-analysis
    Emad Al-Yahya
    Movement Science Group, School of Life Sciences, Oxford Brookes University, Headington, Oxford OX3 0BP, UK
    Neurosci Biobehav Rev 35:715-28. 2011
    ....
  72. ncbi Neuroimaging studies of mental rotation: a meta-analysis and review
    Jeffrey M Zacks
    Department of Psychology, Washington University in Saint Louis, Saint Louis, MO, USA
    J Cogn Neurosci 20:1-19. 2008
    ..The relationship between mental rotation and motor simulation can be understood in terms of how these two processes update spatial reference frames...
  73. pmc Sensorimotor integration in speech processing: computational basis and neural organization
    Gregory Hickok
    Center for Cognitive Neuroscience, Center for Hearing Research, Department of Cognitive Sciences, University of California, Irvine, CA 92697, USA
    Neuron 69:407-22. 2011
    ..The neuroanatomy of the proposed circuit is discussed as well as some probable clinical correlates including conduction aphasia, stuttering, and aspects of schizophrenia...
  74. ncbi The role of the dorsomedial striatum in instrumental conditioning
    Henry H Yin
    Department of Psychology and Brain Research Institute, University of California, Los Angeles, Box 951563, Los Angeles, CA 90095 1563, USA
    Eur J Neurosci 22:513-23. 2005
    ..Taken together, these results suggest that the posterior region of the DMS is a crucial neural substrate for the acquisition and expression of action-outcome associations in instrumental conditioning...
  75. ncbi Insights into the neural basis of response inhibition from cognitive and clinical neuroscience
    Christopher D Chambers
    School of Psychology, Cardiff University, UK
    Neurosci Biobehav Rev 33:631-46. 2009
    ..Finally, in Section 4, we propose a series of technical and conceptual objectives for future studies addressing the neural basis of inhibition...
  76. ncbi Listening to action-related sentences modulates the activity of the motor system: a combined TMS and behavioral study
    G Buccino
    Department of Neuroscience, University of Parma, Via Volturno 39, 43100 Parma, Italy
    Brain Res Cogn Brain Res 24:355-63. 2005
    ..The present data show that processing verbally presented actions activates different sectors of the motor system, depending on the effector used in the listened-to action...
  77. pmc Action control according to TEC (theory of event coding)
    Bernhard Hommel
    Leiden University, Cognitive Psychology Unit, Leiden Institute for Brain and Cognition, Wassenaarseweg 52, 2333 AK, Leiden, The Netherlands
    Psychol Res 73:512-26. 2009
    ....
  78. pmc Failing to deactivate: resting functional abnormalities in autism
    Daniel P Kennedy
    Department of Neurosciences, and Psychology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 103:8275-80. 2006
    ..We speculate that the lack of deactivation in the autism group is indicative of abnormal internally directed processes at rest, which may be an important contribution to the social and emotional deficits of autism...
  79. ncbi Modulation of caudate activity by action contingency
    Elizabeth M Tricomi
    Department of Psychology, University of Pittsburgh, PA 15260, USA
    Neuron 41:281-92. 2004
    ..This finding suggests that the caudate is involved in reinforcement of action potentially leading to reward, rather than in processing reward per se...
  80. pmc Reconciling the role of serotonin in behavioral inhibition and aversion: acute tryptophan depletion abolishes punishment-induced inhibition in humans
    Molly J Crockett
    Behavioral and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, United Kingdom
    J Neurosci 29:11993-9. 2009
    ..These findings extend and clarify previous research on the role of serotonin in aversive processing and behavioral inhibition and fit with current theorizing on the involvement of serotonin in predicting aversive outcomes...
  81. pmc Motor control and aging: links to age-related brain structural, functional, and biochemical effects
    Rachael D Seidler
    School of Kinesiology, University of Michigan, 401 Washtenaw Avenue, Ann Arbor, MI 48109 2214, USA
    Neurosci Biobehav Rev 34:721-33. 2010
    ..Existing exercise, pharmaceutical, and motor training interventions may ameliorate motor deficits in older adults...
  82. ncbi CNS learns stable, accurate, and efficient movements using a simple algorithm
    David W Franklin
    ATR Computational Neuroscience Laboratories, Keihanna Science City, Kyoto 619 0288, Japan
    J Neurosci 28:11165-73. 2008
    ..This model of motor learning offers new insights as to how the brain controls the complex musculoskeletal system and iteratively adjusts motor commands to improve motor skills with practice...
  83. ncbi Brain potentials associated with expected and unexpected good and bad outcomes
    Greg Hajcak
    Department of Psychology, University of Delaware, Newark, Delaware 19716, USA
    Psychophysiology 42:161-70. 2005
    ..These results are discussed in terms of the potential role of expectations in processing errors and negative feedback...
  84. ncbi Anterior cingulate cortex, conflict monitoring, and levels of processing
    V van Veen
    Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Neuroimage 14:1302-8. 2001
    ..These results suggest a highly specific contribution of the ACC to executive functions, through the detection of conflicts occurring at later or response-related levels of processing...
  85. pmc Is the rostro-caudal axis of the frontal lobe hierarchical?
    David Badre
    Department of Cognitive and Linguistic Sciences, Brown University, Providence, Rhode Island 02912, USA
    Nat Rev Neurosci 10:659-69. 2009
    ..To address this gap, this Review surveys anatomical, neuroimaging, electrophysiological and developmental findings, and considers the question: could the organization of the frontal cortex be hierarchical?..
  86. pmc Evidence for a distributed hierarchy of action representation in the brain
    Scott T Grafton
    Department of Psychology, Room 3837, Building 251, University of California, Santa Barbara, CA 93106, United States
    Hum Mov Sci 26:590-616. 2007
    ....
  87. ncbi Modulating irrelevant motion perception by varying attentional load in an unrelated task
    G Rees
    Wellcome Department of Cognitive Neurology, Institute of Neurology, 12 Queen Square, London WC1N 3BG, UK
    Science 278:1616-9. 1997
    ..These findings fulfill the prediction that perception of irrelevant distractors depends on the relevant processing load...
  88. ncbi Cerebellar complex spikes encode both destinations and errors in arm movements
    S Kitazawa
    Information Science Division, Electrotechnical Laboratory, Japan Science and Technology Corporation, Tsukuba
    Nature 392:494-7. 1998
    ..Thus, complex spikes convey multiple types of information, consistent with the idea that they contribute both to the generation of movements and to the gradual, long-term improvement of these movements...
  89. ncbi Knowing where and getting there: a human navigation network
    E A Maguire
    Wellcome Department of Cognitive Neurology, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Science 280:921-4. 1998
    ..These findings outline a network of brain areas that support navigation in humans and link the functions of these regions to physiological observations in other mammals...
  90. ncbi Neural correlates of visual working memory: fMRI amplitude predicts task performance
    Luiz Pessoa
    Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 35:975-87. 2002
    ..Our results indicate that accurate memory depends on strong sustained signals that span the delay interval of WM tasks...
  91. pmc Training induces changes in white-matter architecture
    Jan Scholz
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Oxford, UK
    Nat Neurosci 12:1370-1. 2009
    ..This provides, to the best of our knowledge, the first evidence for training-related changes in white-matter structure in the healthy human adult brain...
  92. ncbi Chondroitinase ABC promotes functional recovery after spinal cord injury
    Elizabeth J Bradbury
    Sensory Function Group, Centre for Neuroscience Research, Hodgkin Building, Kings College London, Guy s Campus, London Bridge, London SE1 1UL, UK
    Nature 416:636-40. 2002
    ..Our results demonstrate that CSPGs are important inhibitory molecules in vivo and suggest that their manipulation will be useful for treatment of human spinal injuries...
  93. ncbi An ERP study of the temporal course of the Stroop color-word interference effect
    M Liotti
    University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284 6240, USA
    Neuropsychologia 38:701-11. 2000
    ....
  94. ncbi The representation of object concepts in the brain
    Alex Martin
    Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, Maryland 20892 1366, USA
    Annu Rev Psychol 58:25-45. 2007
    ..However, some property-based regions seem to show a categorical organization, thus providing evidence consistent with category-based, domain-specific formulations as well...
  95. ncbi Sensory prediction errors drive cerebellum-dependent adaptation of reaching
    Ya weng Tseng
    Dept of Neurology, The Johns Hopkins School of Medicine, Kennedy Krieger Institute, Baltimore, MD 21205, USA
    J Neurophysiol 98:54-62. 2007
    ..Therefore adaptation to visuomotor perturbations depends on the cerebellum and is driven by the mismatch between predicted and actual sensory outcome of motor commands...
  96. ncbi Frontal lobe inputs to the digit representations of the motor areas on the lateral surface of the hemisphere
    Richard P Dum
    Center for the Neural Basis of Cognition and Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 25:1375-86. 2005
    ..Overall, the laminar origins of neurons that interconnect the three cortical areas are typical of "lateral" interactions. Thus, from an anatomical perspective, this cortical network lacks a clear hierarchical organization...
  97. ncbi How green is the grass on the other side? Frontopolar cortex and the evidence in favor of alternative courses of action
    Erie D Boorman
    Centre for Functional MRI of the Brain, University of Oxford, Oxford 0X3 9DU, UK
    Neuron 62:733-43. 2009
    ..Collectively, these findings reveal complementary prefrontal computations essential for promoting short- and long-term behavioral flexibility...
  98. pmc Touching a rubber hand: feeling of body ownership is associated with activity in multisensory brain areas
    H Henrik Ehrsson
    Wellcome Department of Cognitive Neurology, Institute of Neurology, London WC1N 3BG, United Kingdom
    J Neurosci 25:10564-73. 2005
    ..We propose that this could be the mechanism for the feeling of body ownership...
  99. ncbi Dissociable stages of human memory consolidation and reconsolidation
    Matthew P Walker
    Laboratory of Neurophysiology, Massachusetts Mental Health Center, Department of Psychiatry, Harvard Medical School, 74 Fenwood Road, Boston, Massachusetts 02115, USA
    Nature 425:616-20. 2003
    ....
  100. ncbi Event-related functional magnetic resonance imaging in Parkinson's disease before and after levodopa
    B Haslinger
    Neurologische Klinik, Neurozentrum Funktionelle Bildgebung, Klinikum rechts der Isar, Technische Universitat Munchen, Mohlstrasse 28, D 81675 Munchen, Germany
    Brain 124:558-70. 2001
    ..We conclude that levodopa improves impaired motor initiation in the supplementary motor area and decreases hyperfunction of lateral premotor and M1 associated with Parkinson's disease during simple volitional movements...
  101. ncbi "Cool" inferior frontostriatal dysfunction in attention-deficit/hyperactivity disorder versus "hot" ventromedial orbitofrontal-limbic dysfunction in conduct disorder: a review
    Katya Rubia
    Department of Child Psychiatry Medical Research Council Center for Social, Genetic and Developmental Psychiatry, Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 69:e69-87. 2011
    ..There is, hence, evidence for dissociated underlying pathophysiologies for these two disorders that may have implications for future anatomy-based differential diagnosis and prevention and intervention...

Research Grants65

  1. Central Adaptations to Creatine Supplementation in Older Men and Women
    ERIC RAWSON; Fiscal Year: 2007
    ..mass, strength, and endurance in both young and older individuals, and improved cognitive processing, psychomotor performance, mood, balance, and cerebral oxygenation in young individuals...
  2. Licit &Illicit Opioids: Comparative Studies in Humans
    Sharon L Walsh; Fiscal Year: 2013
    ..comparator agents, and 3) multi-dimensional outcomes of safety, subjective reports, observer-rating and psychomotor performance along...
  3. Combined effects of alcohol and caffeine on agency judgment, impulsivity and risk
    ADRIENNE JULIE HEINZ; Fiscal Year: 2011
    ..yet small literature on the conjoint effects of caffeine and alcohol on subjective intoxication and psychomotor performance. These studies collectively demonstrate that although caffeine only mildly antagonizes the effects of ..
  4. Cardiovascular and Metabolic Risk Factors Associated with Short Sleep Duration
    Michael A Grandner; Fiscal Year: 2013
    ..continuity and sleep architecture (via polysomnography), sleepiness (via a Multiple Sleep Latency Test), psychomotor performance (via the Psychomotor Vigilance Task), aortic glucose homeostasis (via an Oral Glucose Tolerance Test) and ..
  5. Clinical Trial of Topiramate for Cocaine Addiction
    Annie Umbricht; Fiscal Year: 2010
    ..in cocaine abusers (alcohol abuse, tobacco use, depression, anxiety, PTSD, pain, neurocognitive and psychomotor performance dysfunction) that may contribute to drug use and/or detrimental effects...
  6. Brain aging and antioxidant supplementation
    Michael J Forster; Fiscal Year: 2010
    ..oxidative stress/damage are useful predictors of the effects of antioxidant supplementation on cognitive/psychomotor performance. These studies will provide specific information about the nature of antioxidant regimens most likely to ..
  7. The Effect of Vaporized Cannabis on Neuropathic Pain in Spinal Cord Injury
    BARTH LANCE WILSEY; Fiscal Year: 2012
    ..Neuropsychological functioning (attention, learning and memory, and psychomotor performance) will be evaluated with the Digit Symbol Modalities Test, the Hopkins Verbal Learning Test, the Grooved ..
  8. Efficacy and Safety of Dronabinol (Oral THC) for Treating Cannabis Dependence
    Ryan G Vandrey; Fiscal Year: 2012
    ..replicate and extend research on the effects of dronabinol on cannabis withdrawal severity, cognitive and psychomotor performance, the acute effects of smoked cannabis, and cannabis self-administration...
  9. New Neural Targets for Opioid Use Disorders: Human Studies
    Sharon L Walsh; Fiscal Year: 2010
    ..Pharmacodynamic outcomes will include subject- and observer-rated measures related to abuse potential, psychomotor performance and physiological indices...
  10. MENSTRUALLY RELATED CHANGES IN COGNITIVE FUNCTION
    Uriel Halbreich; Fiscal Year: 1992
    ..should lead to better understanding of the influence of pituitary and gonadal hormones on cognitive and psychomotor performance. It will also contribute to settle the sex bias originating from stereotyping entire population based on ..
  11. GENDER & OPIOID EFFECTS, INCLUDING ANALGESIA
    James Zacny; Fiscal Year: 2000
    ..The primary endpoint will be analgesia, but other variables will be tested as well, including mood and psychomotor performance. In two studies, healthy volunteers will be exposed to either full mu agonist (Study 1) or mixed agonist-..
  12. Evaluation of Novel Pharmacotherapies for the Treatment of Opioid Dependence
    Sharon L Walsh; Fiscal Year: 2013
    ..A broad array of physiological, subjective, observer-rated and psychomotor performance measures will be collected to assess safety, tolerability and efficacy at withdrawal suppression...
  13. CANNABIS PHARMACOKINETICS: RELATION TO HUMAN PERFORMANCE
    BARBARA MANNO; Fiscal Year: 1992
    ..the subtle effects of smoking graded doses of marihuana on human simple and complex pursuit tracking (psychomotor performance) tasks and on number recall ability, manual dexterity and body's stability over a 32 hour period after an ..
  14. Neurophysiological Correlates of Moderate Alcohol Use in Older Adults.
    JEFFREY B BOISSONEAULT; Fiscal Year: 2011
    ..small acute doses of alcohol have been shown to have subtle, yet measurable effects on neurocognition and psychomotor performance in the user which may confer some risk to that individual...
  15. GENDER DIFFERENCES IN OPIOID ANALGESIA AND SIDE EFFECTS
    Barbara Coda; Fiscal Year: 2002
    ..we will administer repeated trials of pain testing, assessments of subjective effects, cognitive and psychomotor performance, respiratory drive, and pupilometry; i.e., before, during and following opioid infusion...
  16. Metabolism and Pharmacogenetics in MDMA-Induced Toxicity
    Rafael de la Torre; Fiscal Year: 2009
    ..Physiological, and subjective effects, psychomotor performance, hormones and pharmacokinetics will be evaluated...
  17. SMOKING, SCHIZOPHRENIA, AND ATYPICAL ANTIPSYCHOTICS
    Joseph McEvoy; Fiscal Year: 1999
    ..Nicotine corrects certain deficits in sensory gating and cognitive psychomotor performance that are not corrected, or made worse, by haloperidol...
  18. REARING HISTORY AND BEHAVIORAL RESPONSIVENESS TO COCAINE
    Stephen Fowler; Fiscal Year: 1990
    ..discriminative stimulus properties of cocaine and in terms of cocaine's capacity to enhance or disrupt psychomotor performance. Rats with demonstrably different behavioral and neural attributes will be prepared by exposing half of ..
  19. CIRCADIAN PATTERNS OF SLEEP TENDENCY IN THE ELDERLY
    Daniel Buysse; Fiscal Year: 2000
    ..Secondary aims are: To examine age-related differences in circadian patterns of mood, activation, and psychomotor performance; and to examine the relationships between circadian core body temperature (CBT) rhythms and circadian ..
  20. Cannabis Dependence: Imaging and Medication Development
    Scott Lukas; Fiscal Year: 2005
    ..cytidine-5'- diphosphate choline (CDP-choline, citicoline) in reducing cannabis use, and reversing the psychomotor performance deficits, memory loss and sleep disorders that occur during cannabis intoxication and withdrawal...
  21. REHABILITATION OF CIRCADIAN BLINDNESS IN OLDER PEOPLE
    ELIZABETH KLERMAN; Fiscal Year: 1999
    ..and (4) pre-sleep administration of physiological doses of melatonin will improve sleep, cognitive and psychomotor performance measures...
  22. LONG-TERM LORAZEPAM USE AND ACUTE TOXICITY IN THE AGED
    Nunzio Pomara; Fiscal Year: 2005
    ..treatment with lorazepam for GAD, what significant deleterious effects are present in cognitive and psychomotor performance or postural sway following administration of their highest daily Unit dose? Which subject factors (i. e...
  23. CARDIAC SURGERY AND CEREBROVASCULAR COMPLICATIONS
    TODD TROOST; Fiscal Year: 1993
    ..As many as 12,500 patients suffer frank strokes and at least 100,000 manifest measurable deterioration in psychomotor performance after cardiac surgery...
  24. Interactions Between Pomegranate Juice and CYP3A
    Dora Farkas; Fiscal Year: 2007
    ..Thus, the pharmacodynamics of this interaction will be studied by monitoring sedation and psychomotor performance in the absence and presence of pomegranate juice.
  25. A Pharmacological Analysis of Delta 9-THC in Humans
    JOSHUA LILE; Fiscal Year: 2009
    ..and cognition, additional experimental measures to assess reinforcement, subjective ratings, impulsivity, psychomotor performance, learning and memory will also be taken...
  26. ORAL DRUG ABUSE--DETERMINANTS AND CONSEQUENCES
    JOHN FALK; Fiscal Year: 1999
    ..Both unconditioned behavior (e.g., locomotor activity) and psychomotor performance (e.g...
  27. Exercise, Executive Processes and the Aging Brain
    CHARLES HILLMAN; Fiscal Year: 2005
    ..Specifically, efficiency of psychomotor performance declines with advancing age leading to profound effects on older adults' quality of life...
  28. Moderate Alcohol in Older Adults: A Preliminary Study
    Sara Nixon; Fiscal Year: 2004
    ..alcohol and the effects of continued moderate drinking on neurocognitive, neurophysiological, and psychomotor performance as well as psychosocial functioning and adaptation...
  29. BEHAVIORAL EFFECTS OF DRUGS OF ABUSE IN WOMEN
    Thomas Kelly; Fiscal Year: 1999
    ..dimensions of human behavior, including learning ability, reaction time, temporal discrimination, psychomotor performance, food consumption, social behavior, physiological reactivity, tobacco cigarette smoking behavior, mood, ..
  30. AGING AND FITNESS EFFECTS ON PSYCHOMOTOR PERFORMANCE
    CHARLES HILLMAN; Fiscal Year: 1999
    ..It is proposed that the results of this fellowship will aid in advancing our knowledge concerning the health of older adults. ..
  31. MOTOR DEFICIT AND WHITE MATTER LESIONS IN AGING AND AD
    Alan Kluger; Fiscal Year: 1993
    ..impaired elderly subjects by employing a variety of neuropsychological and computerized tests of motor/psychomotor performance. Each of these two subject groups will be equally divided between subjects with an without PWML on MRI...
  32. Effects of Opioid Pharmacotherapy on Functioning
    MIRIAM MINTZER; Fiscal Year: 2008
    ..Data from this project may also enhance the scientific understanding of pharmacological and cognitive mechanisms. ..
  33. Neuroimaging of Benzodiazepine-Induced Amnesia
    MIRIAM MINTZER; Fiscal Year: 2003
    ..Results of the proposed research also will enhance the understanding of the functional neuroanatomy of basic human memory processes. ..
  34. Response Selection as a Function of Age
    Robert Proctor; Fiscal Year: 2002
    ..These guidelines will lead to development of products and environments that allow elderly adults to remain more independent and to engage safely in more activities in their daily lives. ..
  35. Benzodiazepine Use/Abuse: Effects on Memory Mechanisms
    MIRIAM MINTZER; Fiscal Year: 2008
    ..Information from this project can also be used to develop cognitive rehabilitation programs and to tailor drug abuse and anxiety treatment interventions to the specific capabilities of long-term users. ..
  36. BEHAVIORAL EFFECTS OF OPIOIDS IN VOLUNTEERS
    James Zacny; Fiscal Year: 2009
    ..abstract_text> ..
  37. Abuse-Related Effects of Opioids and Adjuvant Drug Used by Chronic Pain Patients
    James P Zacny; Fiscal Year: 2010
    ..g., muscle relaxant B) would be the preferred drug to prescribe when treating chronic nonmalignant pain patients. ..
  38. Self-Focused Attention and Nonconscious Self-Evaluation
    PAUL SILVIA; Fiscal Year: 2005
    ..Examining the cognitive processes that give rise to automatic self-evaluation will enhance psychology's understanding of how to prevent, treat, and regulate maladaptive and self-defeating patterns of thought. ..
  39. CHARACTERIZING PSYCHOACTIVE EFFECTS OF INHALANTS
    James Zacny; Fiscal Year: 2004
    ..In short, in our two proposed series of studies, we are developing a human laboratory model of inhalant abuse by studying potential determinants of abuse liability of inhalants (volatile and gaseous) in healthy volunteers. ..
  40. Public Health Model to Promote Safe Elderly Driving
    Sherrilene Classen; Fiscal Year: 2006
    ..abstract_text> ..
  41. Sustained-Release Naltrexone for Opioid Dependence: Longitudinal Study in Humans
    Sandra D Comer; Fiscal Year: 2010
    ....
  42. Metacognition and Control in Human Learning Memory
    JANET A METCALFE; Fiscal Year: 2010
    ....
  43. Dementia of Parkinson Type: Clinicopathologic Phenotype
    James Galvin; Fiscal Year: 2004
    ..At the completion of the award period, candidate plans to develop an independent R01 project derived from the data generated by the experiments described in this proposal. ..
  44. Motivation and Attention in Marijuana Use and Withdrawal
    Anthony Liguori; Fiscal Year: 2005
    ..abstract_text> ..
  45. Intranasal Methamphetamine: A Pharmacotherapy Model
    Carl Hart; Fiscal Year: 2009
    ....
  46. Drug Effects on Behavior: Workplace Implications
    Carl Hart; Fiscal Year: 2008
    ..Together, the data from the proposed studies will have substantial public health impact and will serve both educational and public policy functions. ..
  47. BUPRENORPHINE ABUSE BY HUMANS--LABORATORY STUDIES
    Sandra Comer; Fiscal Year: 2002
    ....
  48. PAIN AND ANALGESIC RESPONSE--SEX AND HORMONE VARIATIONS
    Sandra Comer; Fiscal Year: 2002
    ..In addition, they will more carefully examine sex differences in analgesic response to butorphanol and morphine, two agonists with differing selectivities for mu and kappa opioid receptors. ..
  49. Age, Physical Activity, Genotype and Cognitive Function
    BRADLEY HATFIELD; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  50. SLEEP DEPRIVATION AND ALCOHOL EFFECTS IN MARIJUANA USERS
    Anthony Liguori; Fiscal Year: 2002
    ..By clarifying the separate and combined effects of marijuana, alcohol, and sleep deprivation on these ecologically valid measures, the results will contribute to the prevention of drug-related highway fatalities. ..
  51. NOVEL COCAINE PHARMACOTHERAPIES: LAB STUDIES
    Margaret Haney; Fiscal Year: 2003
    ....
  52. Perceptual-motor tasks in adults with Down syndrome
    SHANNON RINGENBACH; Fiscal Year: 2006
    ..This information is critical in order to communicate effectively to people with DS in a way that reduces frustration and confusion for all involved. The methods for teaching people with DS could be radically improved by this research. ..
  53. ANTIRETROVIRAL THERAPIES AND SUBSTANCE ABUSE
    David Greenblatt; Fiscal Year: 2002
    ..The in vitro model, if validated, has the potential to provide clinically important information on interactions involving HIV treatments and abusable drugs, at relatively low cost and with no human drug exposure. ..
  54. DOSE/RESPONSE EFFECTS OF BEHAVIORAL INSOMNIA THERAPY
    Jack Edinger; Fiscal Year: 2001
    ..We should also develop a better understanding of the time course over which treatment-related improvements might be expected for insomniacs in general and for specific primary insomniac subtypes. ..
  55. REORGANIZATION OF VISUAL FUNCTIONS AFTER EARLY DEAFNESS
    Daphne Bavelier; Fiscal Year: 2009
    ..In addition, it will provide insights for the development of environments better suited to deaf individuals'needs. ..
  56. Emotion Regulation in Relationships during Separation
    Lisa Diamond; Fiscal Year: 2003
    ..This information will make a significant contribution to research on the multiple biobehavioral processes through which close relationships influence day-to-day emotion regulation and long-term psychological well-being. ..
  57. Working Memory Effects in Sentence Comprehension
    MATTHEW TRAXLER; Fiscal Year: 2004
    ..This knowledge may lead to insights that will help practitioners devise better ways of intervening with under-achieving populations. ..
  58. Age-related changes in proprioceptive acuity
    Susan Brown; Fiscal Year: 2006
    ..abstract_text> ..
  59. Cognition and MRI in Adolescent Cannabis Users
    KRISTA MEDINA; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  60. GARLIC PREPARATIONS AND ANTIRETROVIRAL DRUGS
    David Greenblatt; Fiscal Year: 2004
    ..The work will provide immediately applicable clinical data on garlic interactions with antiretrovirals, as well as mechanistic data identifying the interaction process and its predictability from in vitro models. ..
  61. Effects of Vestibular Loss on Orthostatic Mechanisms
    Scott Wood; Fiscal Year: 2004
    ..This study will provide new information on how vestibular loss might increase susceptibility for orthostatic intolerance, and will provide new insights on otolith- autonomic human subjects. ..
  62. Frontal function in Adolescent Cannabis Use Disorders
    MICHAEL DE BELLIS; Fiscal Year: 2009
    ..This proposal has public health significance because we will comprehensively evaluate the effects of marijuana on adolescent brain and cognitive development, an understudied area. ..
  63. Mechanisms of Alcohol Tolerance and Priming in Humans
    MARK FILLMORE; Fiscal Year: 2009
    ..the role of neurocognitive mechanisms in the treatment efficacy of existing pharmacotherapies, such as naltrexone and acamprosate, as well as some investigational medications that might operate via neurocognitive control mechanisms: ..
  64. Effects of Chronic THC in Adolescence
    Peter J Winsauer; Fiscal Year: 2010
    ..Together, data from these experiments will demonstrate how drug abuse and hormonal status during adolescence may permanently alter brain function and the liability of subsequent abuse of A9-THC. ..
  65. Fetal Programming of Early Development
    CURT ALAN SANDMAN; Fiscal Year: 2010
    ..Prenatal influences of CRH on HPA reactivity (Aim 4) will be evaluated by assessing salivary cortisol at rest and after mild stress. These studies in children are the first to examine the role of prenatal CRH on human development. ..