decision making


Summary: The process of making a selective intellectual judgment when presented with several complex alternatives consisting of several variables, and usually defining a course of action or an idea.

Top Publications

  1. ncbi ESMO Consensus Guidelines for management of patients with colon and rectal cancer. a personalized approach to clinical decision making
    H J Schmoll
    Department of Oncology Haematology, Martin Luther University Halle, Germany
    Ann Oncol 23:2479-516. 2012
  2. ncbi Inhibition and the right inferior frontal cortex
    Adam R Aron
    Department of Experimental Psychology, Downing Street, University of Cambridge, Cambridge CB2 3EB, UK
    Trends Cogn Sci 8:170-7. 2004
  3. pmc Evidence synthesis for decision making 2: a generalized linear modeling framework for pairwise and network meta-analysis of randomized controlled trials
    Sofia Dias
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Med Decis Making 33:607-17. 2013
  4. ncbi Practical clinical trials: increasing the value of clinical research for decision making in clinical and health policy
    Sean R Tunis
    Office of Clinical Standards and Quality, Centers for Medicare and Medicaid Services, Baltimore, MD 21244, USA
    JAMA 290:1624-32. 2003
  5. ncbi Learning the value of information in an uncertain world
    Timothy E J Behrens
    FMRIB Centre, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Nat Neurosci 10:1214-21. 2007
  6. ncbi Interpreting indirect treatment comparisons and network meta-analysis for health-care decision making: report of the ISPOR Task Force on Indirect Treatment Comparisons Good Research Practices: part 1
    Jeroen P Jansen
    Mapi Values, Boston, MA, USA
    Value Health 14:417-28. 2011
  7. ncbi Barriers and facilitators to implementing shared decision-making in clinical practice: update of a systematic review of health professionals' perceptions
    France Legare
    Research Centre of the Centre Hospitalier Universitaire de Québec, Quebec, Canada
    Patient Educ Couns 73:526-35. 2008
  8. ncbi The neural basis of economic decision-making in the Ultimatum Game
    Alan G Sanfey
    Center for the Study of Brain, Mind and Behavior, Princeton University, Princeton, NJ 08544, USA
    Science 300:1755-8. 2003
  9. ncbi Self-control in decision-making involves modulation of the vmPFC valuation system
    Todd A Hare
    Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USA
    Science 324:646-8. 2009
  10. ncbi The TIMI risk score for unstable angina/non-ST elevation MI: A method for prognostication and therapeutic decision making
    E M Antman
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    JAMA 284:835-42. 2000

Detail Information

Publications341 found, 100 shown here

  1. ncbi ESMO Consensus Guidelines for management of patients with colon and rectal cancer. a personalized approach to clinical decision making
    H J Schmoll
    Department of Oncology Haematology, Martin Luther University Halle, Germany
    Ann Oncol 23:2479-516. 2012
    ..This ESMO guideline is recommended to be used as the basis for treatment and management decisions...
  2. ncbi Inhibition and the right inferior frontal cortex
    Adam R Aron
    Department of Experimental Psychology, Downing Street, University of Cambridge, Cambridge CB2 3EB, UK
    Trends Cogn Sci 8:170-7. 2004
    ..Future research should investigate the generality of this proposed inhibitory function to other task domains, and its interaction within a wider network...
  3. pmc Evidence synthesis for decision making 2: a generalized linear modeling framework for pairwise and network meta-analysis of randomized controlled trials
    Sofia Dias
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Med Decis Making 33:607-17. 2013
    ..The approach is illustrated through a range of worked examples for commonly encountered evidence formats. ..
  4. ncbi Practical clinical trials: increasing the value of clinical research for decision making in clinical and health policy
    Sean R Tunis
    Office of Clinical Standards and Quality, Centers for Medicare and Medicaid Services, Baltimore, MD 21244, USA
    JAMA 290:1624-32. 2003
    ..For these changes to occur, clinical and health policy decision makers will need to become more involved in all aspects of clinical research, including priority setting, infrastructure development, and funding...
  5. ncbi Learning the value of information in an uncertain world
    Timothy E J Behrens
    FMRIB Centre, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Nat Neurosci 10:1214-21. 2007
    ..Furthermore, variations in this ACC signal across the population predict variations in subject learning rates. Our results provide a formal account of how we weigh our different experiences in guiding our future actions...
  6. ncbi Interpreting indirect treatment comparisons and network meta-analysis for health-care decision making: report of the ISPOR Task Force on Indirect Treatment Comparisons Good Research Practices: part 1
    Jeroen P Jansen
    Mapi Values, Boston, MA, USA
    Value Health 14:417-28. 2011
    Evidence-based health-care decision making requires comparisons of all relevant competing interventions...
  7. ncbi Barriers and facilitators to implementing shared decision-making in clinical practice: update of a systematic review of health professionals' perceptions
    France Legare
    Research Centre of the Centre Hospitalier Universitaire de Québec, Quebec, Canada
    Patient Educ Couns 73:526-35. 2008
    ..To update a systematic review on the barriers and facilitators to implementing shared decision-making in clinical practice as perceived by health professionals...
  8. ncbi The neural basis of economic decision-making in the Ultimatum Game
    Alan G Sanfey
    Center for the Study of Brain, Mind and Behavior, Princeton University, Princeton, NJ 08544, USA
    Science 300:1755-8. 2003
    The nascent field of neuroeconomics seeks to ground economic decision making in the biological substrate of the brain...
  9. ncbi Self-control in decision-making involves modulation of the vmPFC valuation system
    Todd A Hare
    Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USA
    Science 324:646-8. 2009
    ..It incorporated both taste and health in self-controllers but only taste in non-self-controllers. Activity in DLPFC increased when subjects exercised self-control and correlated with activity in vmPFC...
  10. ncbi The TIMI risk score for unstable angina/non-ST elevation MI: A method for prognostication and therapeutic decision making
    E M Antman
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    JAMA 284:835-42. 2000
    ..Patients with unstable angina/non-ST-segment elevation myocardial infarction (MI) (UA/NSTEMI) present with a wide spectrum of risk for death and cardiac ischemic events...
  11. pmc Evidence synthesis for decision making 4: inconsistency in networks of evidence based on randomized controlled trials
    Sofia Dias
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Med Decis Making 33:641-56. 2013
    ..Empirical indicators that can provide reassurance and the question of how to respond to inconsistency are also discussed. ..
  12. pmc Relating introspective accuracy to individual differences in brain structure
    Stephen M Fleming
    Wellcome Trust Centre for Neuroimaging, University College London, 12 Queen Square, London WC1N 3BG, UK
    Science 329:1541-3. 2010
    ..Our findings point to a focal neuroanatomical substrate for introspective ability, a substrate distinct from that supporting primary perception...
  13. ncbi The physics of optimal decision making: a formal analysis of models of performance in two-alternative forced-choice tasks
    Rafal Bogacz
    Center for the Study of Brain, Mind and Behavior, Princeton University, Princeton, NJ, USA
    Psychol Rev 113:700-65. 2006
    In this article, the authors consider optimal decision making in two-alternative forced-choice (TAFC) tasks...
  14. ncbi Decision-making in the physician-patient encounter: revisiting the shared treatment decision-making model
    C Charles
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ont, Canada
    Soc Sci Med 49:651-61. 1999
    ..Rather than advocating a particular approach, we emphasize the importance of flexibility in the way that physicians structure the decision-making process so that individual differences in patient preferences can be respected...
  15. ncbi How do you feel--now? The anterior insula and human awareness
    A D Bud Craig
    Atkinson Research Laboratory, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    Nat Rev Neurosci 10:59-70. 2009
    ..of conditions and behaviours, from bowel distension and orgasm, to cigarette craving and maternal love, to decision making and sudden insight...
  16. ncbi Choice, uncertainty and value in prefrontal and cingulate cortex
    Matthew F S Rushworth
    Department of Experimental Psychology and Centre for Functional MRI of the Brain, John Radcliffe Hospital, University of Oxford, South Parks Road, Oxford OX1 3UD, UK
    Nat Neurosci 11:389-97. 2008
    ..Representations of reward expectation and of reward prediction errors that are pertinent to decision making, however, are not confined to these regions but are also found in prefrontal and cingulate cortex...
  17. ncbi Neural correlates of decision variables in parietal cortex
    M L Platt
    Center for Neural Science, New York University, New York 10003, USA
    Nature 400:233-8. 1999
    ..Our data indicate that a decision-theoretic model may provide a powerful new framework for studying the neural processes that intervene between sensation and action...
  18. ncbi Decision making, the P3, and the locus coeruleus-norepinephrine system
    Sander Nieuwenhuis
    Department of Cognitive Psychology, Vrije Universiteit, Amsterdam, The Netherlands
    Psychol Bull 131:510-32. 2005
  19. ncbi Heuristic decision making
    Gerd Gigerenzer
    Center for Adaptive Behavior and Cognition, Max Planck Institute for Human Development, 14195 Berlin, Germany
    Annu Rev Psychol 62:451-82. 2011
    ..The big future challenge is to develop a systematic theory of the building blocks of heuristics as well as the core capacities and environmental structures these exploit...
  20. ncbi The role of the dorsal striatum in reward and decision-making
    Bernard W Balleine
    Department of Psychology and the Brain Research Institute, University of California Los Angeles, Los Angeles, California 90095 1563, USA
    J Neurosci 27:8161-5. 2007
    ..We review key evidence from recent studies in rodent, nonhuman primate, and human subjects...
  21. pmc The diffusion decision model: theory and data for two-choice decision tasks
    Roger Ratcliff
    Department of Psychology, Ohio State University, Columbus, OH 43210, U S A
    Neural Comput 20:873-922. 2008
    ..The broad range of applications of the model is also reviewed, including research in the domains of aging and neurophysiology...
  22. ncbi Separate neural systems value immediate and delayed monetary rewards
    Samuel M McClure
    Department of Psychology and Center for the Study of Brain, Mind, and Behavior, Princeton University, Princeton, NJ 08544, USA
    Science 306:503-7. 2004
    ..Furthermore, the relative engagement of the two systems is directly associated with subjects' choices, with greater relative fronto-parietal activity when subjects choose longer term options...
  23. ncbi The neural basis of loss aversion in decision-making under risk
    Sabrina M Tom
    Department of Psychology, University of California Los Angeles UCLA, Franz Hall, Box 951563, Los Angeles, CA 90095 1563, USA
    Science 315:515-8. 2007
    ..Finally, individual differences in behavioral loss aversion were predicted by a measure of neural loss aversion in several regions, including the ventral striatum and prefrontal cortex...
  24. pmc The use of research evidence in public health decision making processes: systematic review
    Lois Orton
    Public Health and Policy, University of Liverpool, Liverpool, Merseyside, United Kingdom
    PLoS ONE 6:e21704. 2011
    ..The objectives of this systematic review were to synthesise empirical evidence on the use of research evidence by public health decision makers in settings with universal health care systems...
  25. ncbi Probabilistic decision making by slow reverberation in cortical circuits
    Xiao Jing Wang
    Volen Center for Complex Systems, Brandeis University, Waltham, MA 02254, USA
    Neuron 36:955-68. 2002
    ..To elucidate synaptic mechanisms of decision making, I investigated a biophysically realistic cortical network model for a visual discrimination experiment...
  26. pmc The neurobiology of decision: consensus and controversy
    Joseph W Kable
    Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuron 63:733-45. 2009
    We review and synthesize recent neurophysiological studies of decision making in humans and nonhuman primates. From these studies, the basic outline of the neurobiological mechanism for primate choice is beginning to emerge...
  27. pmc Representation of confidence associated with a decision by neurons in the parietal cortex
    Roozbeh Kiani
    Howard Hughes Medical Institute, National Primate Research Center and Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    Science 324:759-64. 2009
    ..Monkeys exercised this option in a manner that revealed their degree of certainty. Neurons in parietal cortex represented formation of the direction decision and the degree of certainty underlying the decision to opt out...
  28. pmc Probabilistic population codes for Bayesian decision making
    Jeffrey M Beck
    Department of Brain and Cognitive Sciences, University of Rochester, Rochester, NY 14627, USA
    Neuron 60:1142-52. 2008
    ..Here, we present a neural model of decision making that can perform both evidence accumulation and action selection optimally...
  29. ncbi Psychology and neurobiology of simple decisions
    Philip L Smith
    Department of Psychology, University of Melbourne, Victoria, 3010, Australia
    Trends Neurosci 27:161-8. 2004
    ..Such models provide a quantitative link between the time-course of behavioral decisions and the growth of stimulus information in neural firing data...
  30. ncbi The neural systems that mediate human perceptual decision making
    Hauke R Heekeren
    Neurocognition of Decision Making Group, Max Planck Institute for Human Development, Lentzeallee 94, 14195 Berlin, Germany
    Nat Rev Neurosci 9:467-79. 2008
    Perceptual decision making is the act of choosing one option or course of action from a set of alternatives on the basis of available sensory evidence...
  31. ncbi Neural systems responding to degrees of uncertainty in human decision-making
    Ming Hsu
    Division of Humanities and Social Sciences, 228 77, California Institute of Technology, Pasadena, CA 91125, USA
    Science 310:1680-3. 2005
    ..Neurological subjects with orbitofrontal lesions were insensitive to the level of ambiguity and risk in behavioral choices. These data suggest a general neural circuit responding to degrees of uncertainty, contrary to decision theory...
  32. ncbi Conflict monitoring and decision making: reconciling two perspectives on anterior cingulate function
    Mattew M Botvinick
    Psychology Department, Princeton University, Princeton, New Jersey 08540, USA
    Cogn Affect Behav Neurosci 7:356-66. 2007
    ..According to another influential account, the ACC monitors action outcomes and guides decision making. Both of these perspectives are supported by an abundance of data, making it untenable to reject one view in ..
  33. pmc Shared decision making: a model for clinical practice
    Glyn Elwyn
    Cochrane Institute of Primary Care and Public Health, Neuadd Meirionydd, Cardiff University, Heath Park, Cardiff, UK, CF14 4XN
    J Gen Intern Med 27:1361-7. 2012
    The principles of shared decision making are well documented but there is a lack of guidance about how to accomplish the approach in routine clinical practice...
  34. ncbi Anterior prefrontal function and the limits of human decision-making
    Etienne Koechlin
    Institut National de la Sante et de la Recherche Medicale, Departement d Etudes Cognitives, Ecole Normale Superieure, Universite Pierre et Marie Curie, 9, quai Saint Bernard, 75005 Paris, France
    Science 318:594-8. 2007
  35. ncbi The neural basis of decision making
    Joshua I Gold
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6074, USA
    Annu Rev Neurosci 30:535-74. 2007
    The study of decision making spans such varied fields as neuroscience, psychology, economics, statistics, political science, and computer science...
  36. ncbi An integrative model of shared decision making in medical encounters
    Gregory Makoul
    Program in Communication and Medicine, Division of General Internal Medicine, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, 676 North St Clair, Suite 200, Chicago, IL 60611, USA
    Patient Educ Couns 60:301-12. 2006
    Given the fluidity with which the term shared decision making (SDM) is used in teaching, assessment and research, we conducted a focused and systematic review of articles that specifically address SDM to determine the range of conceptual ..
  37. ncbi Reward representations and reward-related learning in the human brain: insights from neuroimaging
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK
    Curr Opin Neurobiol 14:769-76. 2004
    ..Such representations can be used to guide action selection for reward, a process that depends, at least in part, on orbital and medial prefrontal cortex as well as dorsal striatum...
  38. pmc Knowledge transfer and exchange: review and synthesis of the literature
    Craig Mitton
    University of British Columbia Okanagan, Kelowna, BC
    Milbank Q 85:729-68. 2007
    ..At this time there is an inadequate evidence base for doing "evidence-based" KTE for health policy decision making. Either KTE must be reconceptualized, or strategies must be evaluated more rigorously to produce a richer ..
  39. ncbi Response of neurons in the lateral intraparietal area during a combined visual discrimination reaction time task
    Jamie D Roitman
    Program in Neurobiology and Behavior, Department of Physiology and Biophysics, and Regional Primate Research Center, University of Washington, Seattle, Washington 98195 7290, USA
    J Neurosci 22:9475-89. 2002
    ..A threshold level of LIP activity appears to mark the completion of the decision process and to govern the tradeoff between accuracy and speed of perception...
  40. ncbi Orbitofrontal cortex encodes willingness to pay in everyday economic transactions
    Hilke Plassmann
    California Institute of Technology, Division of Humanities and Social Sciences, MC 228 77, Pasadena, California 91125, USA
    J Neurosci 27:9984-8. 2007
    ..Our results support the hypothesis that the medial orbitofrontal cortex encodes the value of goals in decision making.
  41. ncbi Matching behavior and the representation of value in the parietal cortex
    Leo P Sugrue
    Howard Hughes Medical Institute and Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 304:1782-7. 2004
    ..We found that a simple model based on reward history can duplicate this behavior and that neurons in the parietal cortex represent the relative value of competing actions predicted by this model...
  42. pmc Cortico-striatal connections predict control over speed and accuracy in perceptual decision making
    Birte U Forstmann
    Department of Psychology, University of Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 107:15916-20. 2010
    ..To test these hypotheses-both of which may be true-we conducted two experiments on perceptual decision making in which we used cues to vary the demands for speed vs. accuracy...
  43. pmc Evidence synthesis for decision making 3: heterogeneity--subgroups, meta-regression, bias, and bias-adjustment
    Sofia Dias
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Med Decis Making 33:618-40. 2013
    ..of effect-modifiers and has implications for the interpretation of results in cost-effectiveness analysis and decision making. A distinction is usually made between true variability in treatment effects due to variation in patient ..
  44. pmc Decision making in xia2
    Graeme Winter
    Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE, England
    Acta Crystallogr D Biol Crystallogr 69:1260-73. 2013
    ..While the decision-making protocols described here were developed for xia2, they are equally applicable to interactive data reduction. ..
  45. ncbi Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions
    A Bechara
    Department of Neurology, Division of Behavioral Neurology and Cognitive Neuroscience, University of Iowa College of Medicine, Iowa City, Iowa, USA
    Brain 123:2189-202. 2000
    ..This 'myopia for the future' in VM lesion patients persists in the face of severe adverse consequences, i.e. rising future punishment or declining future reward...
  46. pmc Damage to the prefrontal cortex increases utilitarian moral judgements
    Michael Koenigs
    Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Nature 446:908-11. 2007
    ..These findings indicate that, for a selective set of moral dilemmas, the VMPC is critical for normal judgements of right and wrong. The findings support a necessary role for emotion in the generation of those judgements...
  47. ncbi Shared decision making: really putting patients at the centre of healthcare
    A M Stiggelbout
    Department of Medical Decision Making, Leiden University Medical Centre, Netherlands
    BMJ 344:e256. 2012
    Although many clinicians feel they already use shared decision making, research shows a perception-reality gap. A M Stiggelbout and colleagues discuss why it is important and highlight some best practices.
  48. ncbi ERP correlates of feedback and reward processing in the presence and absence of response choice
    Nick Yeung
    Department of Psychology, Princeton University, Princeton, NJ 08544, USA
    Cereb Cortex 15:535-44. 2005
  49. ncbi The simplest complete model of choice response time: linear ballistic accumulation
    Scott D Brown
    School of Psychology, University of Newcastle, Callaghan, NSW 2308, Australia
    Cogn Psychol 57:153-78. 2008
    We propose a linear ballistic accumulator (LBA) model of decision making and reaction time. The LBA is simpler than other models of choice response time, with independent accumulators that race towards a common response threshold...
  50. pmc The neural correlates of subjective value during intertemporal choice
    Joseph W Kable
    Center for Neural Science, New York University, 4 Washington Place, Room 809, New York, New York 10003, USA
    Nat Neurosci 10:1625-33. 2007
    ..This similarity provides unambiguous evidence that the subjective value of potential rewards is explicitly represented in the human brain...
  51. ncbi Effective leadership and decision-making in animal groups on the move
    Iain D Couzin
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA
    Nature 433:513-6. 2005
    ..Our model provides new insights into the mechanisms of effective leadership and decision-making in biological systems...
  52. ncbi Reinforcement learning signal predicts social conformity
    Vasily Klucharev
    Donders Institute for Brain, Cognition, and Behaviour, Radboud University Nijmegen, 6500 HB Nijmegen, The Netherlands
    Neuron 61:140-51. 2009
    ..These findings provide evidence that social group norms evoke conformity via learning mechanisms reflected in the activity of the rostral cingulate zone and ventral striatum...
  53. ncbi The computation of social behavior
    Timothy E J Behrens
    Oxford Centre for Functional MRI of the Brain FMRIB Centre, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Science 324:1160-4. 2009
  54. ncbi An information theoretical approach to prefrontal executive function
    Etienne Koechlin
    Institut National de la Sante et de la Recherche Medicale, Universite Pierre et Marie Curie, 9 Quai St Bernard, 75005 Paris, France
    Trends Cogn Sci 11:229-35. 2007
    ..The theory clarifies how executive control can operate as a unitary function, despite the requirement that information be integrated across multiple distinct, functionally specialized prefrontal regions...
  55. pmc Opponency revisited: competition and cooperation between dopamine and serotonin
    Y Lan Boureau
    The Courant Institute of Mathematical Sciences, New York University, New York, NY, USA
    Neuropsychopharmacology 36:74-97. 2011
    ..We use this analysis to shed light on aspects of the role of serotonin and its interactions with dopamine...
  56. ncbi Behavioral theories and the neurophysiology of reward
    Wolfram Schultz
    Department of Anatomy, University of Cambridge, CB2 3DY United Kingdom
    Annu Rev Psychol 57:87-115. 2006 elucidate the neural correlates for reward functions in learning, goal-directed approach behavior, and decision making under uncertainty...
  57. ncbi Unconscious determinants of free decisions in the human brain
    Chun Siong Soon
    Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstrasse 1a, 04103 Leipzig, Germany
    Nat Neurosci 11:543-5. 2008
    ..This delay presumably reflects the operation of a network of high-level control areas that begin to prepare an upcoming decision long before it enters awareness...
  58. ncbi Banburismus and the brain: decoding the relationship between sensory stimuli, decisions, and reward
    Joshua I Gold
    Department of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuron 36:299-308. 2002
    ..In the codebreaking scheme, the threshold determined the speed and accuracy of the decision process. Here we propose that in the brain, the threshold may be controlled by neural circuits that calculate the rate of reward...
  59. pmc Neurons in the frontal lobe encode the value of multiple decision variables
    Steven W Kennerley
    Helen Wills Neuroscience Institute and Department of Psychology, University of California, Berkeley, CA 94720 3190, USA
    J Cogn Neurosci 21:1162-78. 2009
    ..A key brain region in decision making is the frontal cortex as damage here impairs the ability to make optimal choices across a range of decision ..
  60. pmc Absolute cardiovascular disease risk and shared decision making in primary care: a randomized controlled trial
    Tanja Krones
    Department of General Practice Family Medicine, Phillips University Marburg, Marburg, Germany
    Ann Fam Med 6:218-27. 2008
    We wanted to determine the effect of promoting the effective communication of absolute cardiovascular disease (CVD) risk and shared decision making through disseminating a simple decision aid for use in family practice consultations.
  61. pmc Distinct roles of rodent orbitofrontal and medial prefrontal cortex in decision making
    Jung Hoon Sul
    Neuroscience Laboratory, Institute for Medical Sciences, Ajou University School of Medicine, Suwon 443 721, Korea
    Neuron 66:449-60. 2010
    We investigated how different subregions of rodent prefrontal cortex contribute to value-based decision making, by comparing neural signals related to animal's choice, its outcome, and action value in orbitofrontal cortex (OFC) and ..
  62. ncbi Increased activation in the right insula during risk-taking decision making is related to harm avoidance and neuroticism
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine, Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0603, USA
    Neuroimage 19:1439-48. 2003
    b>Decision making and risk taking are interrelated processes that are important for daily functioning...
  63. ncbi Value computations in ventral medial prefrontal cortex during charitable decision making incorporate input from regions involved in social cognition
    Todd A Hare
    Computation and Neural Systems and Humanities and Social Science Divisions, California Institute of Technology, Pasadena, California 91125 7700, USA
    J Neurosci 30:583-90. 2010
    ..of basic rewards at the time of choice, suggesting that it might serve as a common valuation system during decision making. In addition, functional connectivity analyses indicated that the value signal in VMPFC might integrate ..
  64. ncbi Evaluating the impact of health promotion programs: using the RE-AIM framework to form summary measures for decision making involving complex issues
    Russell E Glasgow
    Kaiser Permanente Colorado, Clinical Research Unit, 335 Road Runner Lane Penrose, Denver, CO 81240, USA
    Health Educ Res 21:688-94. 2006
    ..Such approaches offer potential to help identify interventions most likely to meaningfully impact population health...
  65. ncbi The effect of stimulus strength on the speed and accuracy of a perceptual decision
    John Palmer
    Department of Psychology, University of Washington, Seattle, WA, USA
    J Vis 5:376-404. 2005
    ..In this article, we describe a theory of perceptual decision making based on a diffusion model...
  66. ncbi The neural mechanisms of inter-temporal decision-making: understanding variability
    Jan Peters
    Department of Systems Neuroscience, University Medical Centre Hamburg Eppendorf, Martinistrase 52, 20246 Hamburg, Germany
    Trends Cogn Sci 15:227-39. 2011
    ..Although the precise neural mechanisms underlying many of these modulating influences are only beginning to be unravelled, they point towards novel treatment approaches for disorders of impulse control...
  67. ncbi The OPTION scale: measuring the extent that clinicians involve patients in decision-making tasks
    Glyn Elwyn
    Primary Care Group, School of Medicine, University of Wales Swansea, Swansea, UK
    Health Expect 8:34-42. 2005
    To examine the psychometric properties of a revised scale, named 'observing patient involvement in decision making' (OPTION), by analysing its reapplication to a sample of routine primary care consultations...
  68. ncbi Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective
    Antoine Bechara
    Institute for the Neurological Study of Emotion and Creativity, Department of Psychology, University of Southern California, Los Angeles, California 90089 2520, USA
    Nat Neurosci 8:1458-63. 2005
    ..addiction is the product of an imbalance between two separate, but interacting, neural systems that control decision making: an impulsive, amygdala system for signaling pain or pleasure of immediate prospects, and a reflective, ..
  69. pmc Improving clinical practice using clinical decision support systems: a systematic review of trials to identify features critical to success
    Kensaku Kawamoto
    Division of Clinical Informatics, Department of Community and Family Medicine, Box 2914, Duke University Medical Center, Durham, NC 27710, USA
    BMJ 330:765. 2005
    ..To identify features of clinical decision support systems critical for improving clinical practice...
  70. ncbi Intention, action planning, and decision making in parietal-frontal circuits
    Richard A Andersen
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Neuron 63:568-83. 2009
    ..This review covers new research on four components of this transformation process: planning, decision making, forward state estimation, and relative-coordinate representations...
  71. ncbi Object perception as Bayesian inference
    Daniel Kersten
    Department of Psychology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Annu Rev Psychol 55:271-304. 2004
    ..Recent work in Bayesian theories of visual perception has shown how complexity may be managed and ambiguity resolved through the task-dependent, probabilistic integration of prior object knowledge with image features...
  72. ncbi Diminishing reciprocal fairness by disrupting the right prefrontal cortex
    Daria Knoch
    Institute for Empirical Research in Economics, University of Zurich, Blumlisalpstrasse 10, 8006 Zurich, Switzerland
    Science 314:829-32. 2006
    ..Importantly, however, subjects still judge such offers as very unfair, which indicates that the right DLPFC plays a key role in the implementation of fairness-related behaviors...
  73. ncbi Neural correlates, computation and behavioural impact of decision confidence
    Adam Kepecs
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 455:227-31. 2008
    ..We suggest that confidence estimation may be a fundamental and ubiquitous component of decision-making...
  74. pmc Cortical substrates for exploratory decisions in humans
    Nathaniel D Daw
    Gatsby Computational Neuroscience Unit, University College London UCL, Alexandra House, 17 Queen Square, London WC1N 3AR, UK
    Nature 441:876-9. 2006
    b>Decision making in an uncertain environment poses a conflict between the opposing demands of gathering and exploiting information...
  75. ncbi Flexible control of mutual inhibition: a neural model of two-interval discrimination
    Christian K Machens
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Science 307:1121-4. 2005
    ..The model integrates both working memory and decision making because its dynamical properties are easily controlled without changing its connectivity...
  76. pmc Optimally interacting minds
    Bahador Bahrami
    University College London Institute of Cognitive Neuroscience, University College London, Alexandra House, 17 Queen Square, London WC1N 3AR, UK
    Science 329:1081-5. 2010
    ..These seemingly discrepant patterns of group behavior can be explained by a model in which two heads are Bayes optimal under the assumption that individuals accurately communicate their level of confidence on every trial...
  77. pmc Evidence synthesis for decision making 5: the baseline natural history model
    Sofia Dias
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Med Decis Making 33:657-70. 2013
  78. pmc The role of medial prefrontal cortex in memory and decision making
    David R Euston
    Department of Neuroscience, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada
    Neuron 76:1057-70. 2012
    Some have claimed that the medial prefrontal cortex (mPFC) mediates decision making. Others suggest mPFC is selectively involved in the retrieval of remote long-term memory...
  79. ncbi Perceptions of moral character modulate the neural systems of reward during the trust game
    M R Delgado
    Department of Psychology, 6 Washington Place, New York University, New York, New York 10003, USA
    Nat Neurosci 8:1611-8. 2005
  80. pmc Variance as a signature of neural computations during decision making
    Anne K Churchland
    Department of Physiology and Biophysics, University of Washington Medical School, National Primate Research Center, Seattle, WA 98195 7290, USA
    Neuron 69:818-31. 2011
    ..These analyses help to differentiate among several alternative decision-making models...
  81. ncbi Neural representation of task difficulty and decision making during perceptual categorization: a timing diagram
    Marios G Philiastides
    Laboratory for Intelligent Imaging and Neural Computing, Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
    J Neurosci 26:8965-75. 2006
    ..We use these results to develop a timing diagram for perceptual decision making and relate the component activities to parameters of a diffusion model for decision making.
  82. ncbi Optimal decision making and the anterior cingulate cortex
    Steven W Kennerley
    Department of Experimental Psychology, South Parks Road, Oxford OX1 3UD, UK
    Nat Neurosci 9:940-7. 2006
    Learning the value of options in an uncertain environment is central to optimal decision making. The anterior cingulate cortex (ACC) has been implicated in using reinforcement information to control behavior...
  83. pmc Decision making in recurrent neuronal circuits
    Xiao Jing Wang
    Department of Neurobiology and Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA
    Neuron 60:215-34. 2008
    b>Decision making has recently emerged as a central theme in neurophysiological studies of cognition, and experimental and computational work has led to the proposal of a cortical circuit mechanism of elemental decision computations...
  84. ncbi Neural activity in the human brain relating to uncertainty and arousal during anticipation
    H D Critchley
    Wellcome Department of Cognitive Neurology, 12 Queen Square, Institute of Neurology, University College London, WC1N 3BG, London, United Kingdom
    Neuron 29:537-45. 2001
    ..Our findings highlight distinct contributions of cognitive uncertainty and autonomic arousal to anticipatory neural activity in prefrontal cortex...
  85. pmc Improving the reporting of pragmatic trials: an extension of the CONSORT statement
    Merrick Zwarenstein
    Health Services Sciences, Sunnybrook Hospital, Toronto, Ontario, Canada
    BMJ 337:a2390. 2008
    ..In the meantime we recommend that those who support, conduct, and report pragmatic trials should use this extension of the CONSORT statement to facilitate the use of trial results in decisions about health care...
  86. pmc Barriers to evidence-based decision making in public health: a national survey of chronic disease practitioners
    Julie A Jacobs
    Prevention Research Center in St Louis, Saint Louis University School of Public Health, St Louis, MO, USA
    Public Health Rep 125:736-42. 2010
    ..This study investigated state and territorial chronic disease practitioners' self-reported barriers to evidence-based decision making (EBDM).
  87. pmc Striatum and pre-SMA facilitate decision-making under time pressure
    Birte U Forstmann
    Department of Psychology, Amsterdam Center for the Study of Adaptive Control in Brain and Behavior, University of Amsterdam, 1018 WB, Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 105:17538-42. 2008
    ..These results demonstrate that when people have to make decisions under time pressure their striatum and pre-SMA show increased levels of activation...
  88. ncbi Coding of reward risk by orbitofrontal neurons is mostly distinct from coding of reward value
    Martin O'Neill
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing Street, Cambridge CB23DY, UK
    Neuron 68:789-800. 2010
    ..Furthermore, a small but statistically significant fraction of risk responses also coded reward value. These risk signals may provide physiological correlates for the role of the orbitofrontal cortex in risk processing...
  89. ncbi Probabilistic reasoning by neurons
    Tianming Yang
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, National Primate Research Center, University of Washington, Box 357290, Seattle, Washington 98195 7290, USA
    Nature 447:1075-80. 2007
    ..Monkeys learned to combine probabilistic information from the shape combinations. Moreover, neurons in the parietal cortex reveal the addition and subtraction of probabilistic quantities that underlie decision-making on this task...
  90. ncbi Neural response to reward anticipation under risk is nonlinear in probabilities
    Ming Hsu
    Beckman Institute for Advanced Science and TechnologyUniversity of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Neurosci 29:2231-7. 2009
    A widely observed phenomenon in decision making under risk is the apparent overweighting of unlikely events and the underweighting of nearly certain events...
  91. ncbi Neural computations associated with goal-directed choice
    Antonio Rangel
    HSS and CNS, California Institute of Technology, 1200 E California Boulevard, Pasadena, CA, USA
    Curr Opin Neurobiol 20:262-70. 2010
    ..We review some important findings, with an emphasis on computational models, human fMRI, and monkey neurophysiology studies...
  92. ncbi The neuropeptide oxytocin regulates parochial altruism in intergroup conflict among humans
    Carsten K W De Dreu
    Department of Psychology, University of Amsterdam, Roetersstraat 15, 1018 WB Amsterdam, Netherlands
    Science 328:1408-11. 2010
    ..Results showed that oxytocin drives a "tend and defend" response in that it promoted in-group trust and cooperation, and defensive, but not offensive, aggression toward competing out-groups...
  93. ncbi Reasoning the fast and frugal way: models of bounded rationality
    G Gigerenzer
    Center for Adaptive Behavior and Cognition, Max Planck Institute for Psychological Research, Munich, Germany
    Psychol Rev 103:650-69. 1996
    ..the authors have proposed a family of algorithms based on a simple psychological mechanism: one-reason decision making. These fast and frugal algorithms violate fundamental tenets of classical rationality: They neither look up ..
  94. ncbi Dissociating the role of the orbitofrontal cortex and the striatum in the computation of goal values and prediction errors
    Todd A Hare
    Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 28:5623-30. 2008
  95. pmc Neural correlates of value, risk, and risk aversion contributing to decision making under risk
    George I Christopoulos
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK
    J Neurosci 29:12574-83. 2009
    b>Decision making under risk is central to human behavior. Economic decision theory suggests that value, risk, and risk aversion influence choice behavior...
  96. pmc Quorum decision-making facilitates information transfer in fish shoals
    Ashley J W Ward
    Centre for Mathematical Biology, School of Biological Sciences, University of Sydney, Sydney, New South Wales 2006, Australia
    Proc Natl Acad Sci U S A 105:6948-53. 2008
    ..This study shows that effective and accurate information transfer in groups may be gained only through nonlinear responses of group members to each other, thus highlighting the importance of quorum decision-making...
  97. ncbi The neural correlates of theory of mind within interpersonal interactions
    James K Rilling
    Center for the Study of Brain, Mind and Behavior, Princeton University, Princeton, NJ 08544, USA
    Neuroimage 22:1694-703. 2004
    ..Although computer partners elicited activation in some of the same areas activated by human partners, most of these activations were stronger for human partners...
  98. pmc Risky business: the neuroeconomics of decision making under uncertainty
    Michael L Platt
    Center for Neuroeconomic Studies, Room B243F LSRC Building, Duke University, Durham, North Carolina 27708 0999, USA
    Nat Neurosci 11:398-403. 2008
    ..or a foreign oil company in a hedge fund, can have negative consequences, but the impact of uncertainty on decision making extends beyond gambling. Indeed, uncertainty in some form pervades nearly all our choices in daily life...
  99. ncbi How green is the grass on the other side? Frontopolar cortex and the evidence in favor of alternative courses of action
    Erie D Boorman
    Centre for Functional MRI of the Brain, University of Oxford, Oxford 0X3 9DU, UK
    Neuron 62:733-43. 2009
    ..Collectively, these findings reveal complementary prefrontal computations essential for promoting short- and long-term behavioral flexibility...
  100. pmc Counterfactual choice and learning in a neural network centered on human lateral frontopolar cortex
    Erie D Boorman
    Department of Experimental Psychology, University of Oxford, Oxford, UK
    PLoS Biol 9:e1001093. 2011
    b>Decision making and learning in a real-world context require organisms to track not only the choices they make and the outcomes that follow but also other untaken, or counterfactual, choices and their outcomes...
  101. ncbi Decision making under stress: a selective review
    Katrin Starcke
    Department of General Psychology Cognition, University of Duisburg Essen, 47057 Duisburg, Germany
    Neurosci Biobehav Rev 36:1228-48. 2012
    ..Thus, stress and decision making are intricately connected, not only on the behavioral level, but also on the neural level, i.e...

Research Grants92

  1. Transforming PCI Informed Consent into an Evidence-based Decision-making Tool
    John A Spertus; Fiscal Year: 2010
    ..the need to transparently display patients risks at the time of treatment to support more rational decision making. The impact of PRISM on the use of BATs, as a function of pre-procedural risk, will be tested within study ..
  2. Emergency Neurophysiological Assessment Bedside Logic Engine
    Don M Tucker; Fiscal Year: 2010
    ..The improved pattern recognition of neuropathology then paves the way to improved clinical decision making. Through the fusion of automated neurophysiological pattern recognition, ENABLE not only summarizes the ..
  3. Disease chronicity in juvenile dermatomyositis (JDM): Epigenetic clues
    Lauren M Pachman; Fiscal Year: 2013
    ..It is anticipated that the scientific knowledge gained from the proposed work will inform our future decision making and lead to more rational and effective interventions...
  4. Real-Time Optical Diagnosis of Inflammatory Bowel Disease using SFDI
    Sylvain Gioux; Fiscal Year: 2013
    ..visual examination through a color videoscope, with tissue appearance and color guiding biopsy and clinical decision making. Given that IBD has a prevalence of over 1...
  5. Calorie Restriction &Body Composition, Function, &QoL in Older Adults
    Julie L Locher; Fiscal Year: 2013
  6. Validation of Novel Infertility Biomarker
    PETER SUTOVSKY SUTOVSKY; Fiscal Year: 2012
    ..Annually, more than 135,000 infertile couples are treated for infertility in US clinics, where the treatment-decision making still relies on outdated, highly subjective light microscopic method of semen evaluation.
  7. Frontal Lobe Injury and Executive Control of Cognition and Emotion
    Diane Swick; Fiscal Year: 2013
    ..or the ability to withhold pre-potent motor responses;(2) impulsive choice in the context of reward, or decision making without regard to future consequences;(3) emotion regulation, or the ability to control affective responses...
  8. STRAW+10: Addressing the Unfinished Agenda of Staging Reproductive Aging - RESUBM
    Sioban D Harlow; Fiscal Year: 2011
    ..We also propose to extend the STRAW recommendations to be more broadly applicable to the range of women's diverse experience of reproductive aging. ..
  9. Mechanisms Underlying Social Cooperative Behavior
    LUKE JOSEPH CHANG; Fiscal Year: 2010
  10. Biomedical Computing Support of Cancer Control and Surveillance
    DAVID RONEY; Fiscal Year: 2009
    ..Central to these activities is the process of synthesis and decision making that aids in: - evaluating what has been learned, - identifying new priorities and strategies, and - ..
  11. Multifunctional nanoformulations for diagnostic imaging of atherosclerosis
    Alexander B Sigalov; Fiscal Year: 2012
  12. Financial Risks and Ethnic/Racial Disparities in Live Kidney Donation
    TANJALA PURNELL; Fiscal Year: 2011
  13. Volumetric Perfusion MRI of Liver Tumors to Detect Early Response to Chemotherapy
    Scott B Reeder; Fiscal Year: 2010
    ..Using the new perfusion MRI methods, the effectiveness of the drug will be ascertained in 2 days, and the prolonged use of ineffective, toxic and expensive drugs can be avoided and alternative therapies pursued. ..
  14. Population-Based Reference Ranges for Estradiol and Estrone in Men
    VASAN S RAMACHANDRAN; Fiscal Year: 2013
    ..Reference limits for total and free E1 and E2 levels are essential for clinical decision making. In the absence of rigorously-derived reference ranges, the partitioning of total and free E1 and E2 levels ..
  15. CRCNS: Theory and experiment of neural circuit mapping by DNA sequencing
    Anthony M Zador; Fiscal Year: 2013
    ..A wide range of brain functions, including sensory perception, learning, memory, decision making, cognition, reasoning, and communication, is therefore related to the details of this neuronal connectivity...
  16. Clinical Decision Support for Mild Traumatic Brain Injury
    EDWARD ROBERT MELNICK; Fiscal Year: 2013
    ..The tool will include special provisions for shared decision- making with the elderly, another AHRQ priority population. ..
  17. Development of an HIV Risk Reduction Intervention Protocol for Adolescent Africn-
    GWENDOLYN D CHILDS; Fiscal Year: 2012
    ..With a growing HIV epidemic in the Southern part of the United States, it is imperative to develop HIV risk reduction programs for African American adolescent girls prior to sexual debut or onset of high-risk sexual behavior. ..
  18. Proteomic Identification of Actionable Biomarkers in Rheumatoid Arthritis
    William H Robinson; Fiscal Year: 2010
    ..6% of the world population. This proposal will identify novel autoantibody and cytokine biomarkers for (i) early diagnosis, (ii) predicting disease severity, and (iii) guiding therapeutic decision making for the treatment of RA.
  19. Partnership for Primary Care Imaging
    Stephen A Boppart; Fiscal Year: 2013
    ..has traditionally relied on physical exam skills and simplistic instruments for critical diagnostic decision making, monitoring, and referral to medical specialists...
    JEFFREY SCOTT BARRETT; Fiscal Year: 2010
    ..prescribing errors can be reduced via intelligent decision support systems that facilitate pharmacotherapy decision making [2]...
  21. Translational refinement of adaptive communication system for locked-in patients
    Melanie Fried-Oken; Fiscal Year: 2013
    ..These individuals with limited to no movement could potentially contribute to their medical decision making, informed consent, and daily care giving if they had faster, more reliable means to interface with ..
  22. Ontogenic factors in adolescent-emergent depression and decision-making
    SHANNON LEIGH GOURLEY; Fiscal Year: 2013
  23. Nanoscale analysis of proteomic response to novel targeted therapies for lymphoma
    ALICE CHEN FAN; Fiscal Year: 2013
    ..incorporate potential new biomarkers into patient oriented research to validate biomarkers for clinical decision making. At the bench, I have developed a novel nanofluidic proteomic immunoassay (NIA) for the analysis of ..
  24. Function of Microtubule Plus-End-Tracking Proteins in the Neuronal Growth Cone
    Laura Anne Lowery; Fiscal Year: 2013
  25. System for Tracking and Managing Pain (STAMP)
    Wendy A Rogers; Fiscal Year: 2012
    ..STAMP will be designed to support self-management through education and shared medical decision making by patients and their healthcare providers to better manage chronic OA pain thereby decreasing the demand for ..
  26. Metabolic Effects of Antipsychotics in Children
    John W Newcomer; Fiscal Year: 2010
    ..Relevant data are critically needed to assess the risks of antipsychotic therapy in children, to identify targets for additional basic research, and to guide clinical decision-making. ..
  27. Feasibility, Efficacy, and Mechanisms of Surgical vs Medical Diabetes Treatment
    David R Flum; Fiscal Year: 2012
    ..abstract_text> ..
  28. Shared Decision Making In Pediatric Chronic Conditions: Biologics in IBD and JIA
    Ellen A Lipstein; Fiscal Year: 2013
    ..require additional training to enhance her trajectory toward becoming an independent investigator: 1) Medical decision making in pediatric chronic disease;2) De- cision aid development and implementation;and 3) Advanced methodologic ..
  29. Comparative Effectiveness of Advanced Diagnostic Imaging for Hepatic Fibrosis
    Jayant A Talwalkar; Fiscal Year: 2010
    ..The impact of noninvasive testing methods and liver biopsy on clinical decision making and patient-related outcomes will include assessments of procedure-related adverse events, false-positive and ..
  30. Improved Source Localization for Pediatric Epilepsy
    Damon Hyde; Fiscal Year: 2013
    ..understanding of clinical procedure and the ways in which various sources of information affect diagnostic decision making. I will regularly attend surgical planning conferences, and observe the final resection procedures...
  31. Octopamine Neuroanatomy and Functioning in Fruit Fly Social Behavior
    KYLE LYNN GOBROGGE; Fiscal Year: 2013
    ..The results from previous work have demonstrated that these FruM/OA cells are involved in decision making by males between courtship and aggression...
  32. Wound EMR to Decrease Limb Amputations in Persons with Diabetes
    Harold Brem; Fiscal Year: 2010
    William B Kristan; Fiscal Year: 2013
    ..The comparative approach has a long and fruitful history: questions answered in simple animals provide information and inspiration for asking the same questions in more complex animals, like rats, monkeys, and eventually humans. ..
  34. Clinical Outcomes for Siblings of Children with Vesico-Ureteral Reflux
    CALEB PENNELL NELSON; Fiscal Year: 2013
    ..abstract_text> ..
  35. Developing Radiological Risk Communication Materials for Low-Literacy Populations
    SARAH B BASS; Fiscal Year: 2010 the case of a terror event, but also advance the science of developing interdisciplinary models that improve decision making under uncertainty using innovative methods such as perceptual mapping and physiological testing.
  36. Reversing Non-adherence in American Indians with Diabetes Mellitus Type Two
    Marlene K Wilken; Fiscal Year: 2012
    ..The desired outcome is that AIs with DM2 who receive culturally appropriate diabetes self-management education will have improved self-care adherence, outcomes and quality of life. ..
  37. Established Investigator Award in Cancer Prevention and Control
    Thomas L Vaughan; Fiscal Year: 2013
    ..Each year, he plans to work closely with two to three predoctoral students, one to two postdoctoral fellows;and one to two junior faculty members. ..
  38. Infant Antibiotic Resistance and Implications for Therapeutic Decision-making
    SHARON MEROPOL; Fiscal Year: 2013
    ..The plan includes training by recognized and successful mentors to cultivate unique skills that can be applied in future independent research. ..
  39. Personality and Health Services Use and Expenditures of Older Persons
    Bruce Friedman; Fiscal Year: 2010
  40. Non-invasive evaluation of Non-alcoholic Steatohepatitis
    Michelle Lai; Fiscal Year: 2013
    ..John B. Wong, Professor of Medicine in the Division of Clinical Decision Making, Informatics and Telemedicine at the Tufts Medical Center will serve as mentors...
  41. Telehealth-Enabled Ultrasound-Bioimpedance Viscoelastographic Edema Monitoring
    William F Weitzel; Fiscal Year: 2013
    ..Currently, serial physical examinations by a skilled clinician provide the input for clinical decision making. However, serial examinations are a challenge, especially in rural, medically underserved communities and ..
    Young Hoon Sung; Fiscal Year: 2013
  43. Fatal Choice - Behavioral Economics of Vulnerability for Late-Life Suicide
    KATALIN NONE SZANTO; Fiscal Year: 2011
    ..One important factor that is particularly relevant to suicide is the role of emotion in decision making. Depression and suicide are clearly linked, but exactly how depression leads to suicide, or why it does so in ..
  44. Dopamine and the Role of Anterior Cingulate Cortex in Executive Processes
    Benjamin Y Hayden; Fiscal Year: 2013
    ..Given the prominence of the Platt Lab and of Duke University, this is an ideal environment to perform the research described in this application. ..
  45. Targeted screening for Taenia solium tapeworms
    SETH E O'NEAL; Fiscal Year: 2011
    ..This proposal examines targeted screening for pork tapeworm carriers as a potentially effective, affordable and sustainable control strategy. ..
  46. Development and Pilot Test of an Elective BSO Decision Support Guide
    Miriam Kuppermann; Fiscal Year: 2010
    ..Clearly, decision making around BSO is an area the meets these criteria...
    Amy L Salisbury; Fiscal Year: 2013
    ..versus exposure to untreated MDD, with respect to later development, greatly hinders informed risk-benefit decision making for MDD treatment during pregnancy...
  48. Transcriptomics in Traumatic Brain Injury: Relationship to Brain Oxygenation and
    Ava M Puccio; Fiscal Year: 2013
    ..The nurse is the optimal health care provider to assist the individual/family in the decision making process...
  49. Comparative Effectiveness of Dialysis Modalities
    Rajnish Mehrotra; Fiscal Year: 2013
    ..generate a wealth of time-sensitive information about two increasingly popular dialysis therapies that will be of immediate clinical and public health relevance and inform decision making by physicians, patients, providers, and payers.
  50. Miami Womens Interagency HIV Study WIHS
    Lisa R Metsch; Fiscal Year: 2013
    ..The proposed research projects will examine the impact of aging on immune functionality;reproductive decision making among young adult and adult women living with HIV/AIDS;increasing viral diversity and the impact of HIV-1 non-..
  51. Endovascular Magnetic Catheter for Interventional MRI
    STEVEN WILLIAM HETTS; Fiscal Year: 2013 performed under MRI guidance, then real time physiologic MR imaging can be used to augment intraprocedural decision making, potentially allowing new patients to receive endovascular therapy and improving clinical outcomes...
  52. Brain Activation in Humans
    Andrew J Butler; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): There is a growing need for evidence to support clinical decision making in rehabilitation. Advancements in neuroimaging are essential for the support and refinement of rehabilitative interventions...
  53. The Living Well Project: Early Palliative Care and MI for persons with AIDS
    Tammie E Quest; Fiscal Year: 2013
    ..provide supportive care, symptom management, and facilitate adjustment to diagnosis and advance care planning decision making. The project has three specific aims: 1...
  54. Diabetic Foot and Pressure Ulcer Databank
    Harold Brem; Fiscal Year: 2009 healthcare professionals, regardless of their geographic location, could potentially improve clinical decision making in the management of wounds and, consequently, decrease the morbidity and mortality in more than 3 million ..
  55. Quantitative Optical Imaging of Molecular Processes in Preclinical Cancer Models
    WALTER JOHN AKERS; Fiscal Year: 2013
    ..Detection of therapeutic response early initiation can speed the clinical decision- making process and improve overall response. Non-invasive imaging techniques are needed for this purpose. ..
  56. Neural Encoding of Internal Motivational States and Goal-Directed Actions
    ALAINA CATHERINE CASE; Fiscal Year: 2011
  57. Using CERs to Optimize Quality of Life for Persons with Diabetes and Chronic Pain
    Monika M Safford; Fiscal Year: 2010
    ..In the course of the trial, we will examine how five Comparative Effectiveness Reviews can be adapted to best impact clinical decision-making to improve health outcomes. ..
  58. An Individually-Tailored Mammography Screening Intervention for Chinese Americans
    Tsu Yin Wu; Fiscal Year: 2010
    ..If the program is shown to be successful, the intervention strategies may serve as a model with other Asian Americans and minority groups, and also improve the utilization of other types of cancer screening tests as well. ..
  59. A Translational Framework for Methodological Rigor to Improve Patient Centered Ou
    Francesca Dominici; Fiscal Year: 2013
    ..experts in health care policy, CER, oncology, health disparities, palliative care, neuro-oncology, and decision making for health care reimbursement...
  60. Cognitive Impairment and Self-management in Adults with Heart Failure
    Joel W Hughes; Fiscal Year: 2013
    ..heart failure (HF) depends on self-management that includes adherence to the treatment regimen and effective decision making and corrective action when HF symptoms are exacerbated...
  61. Self-Management, Biobehavioral and Informatics Core
    Nancy E Reame; Fiscal Year: 2011
    ..External Advisory Board) directs a program of research on health information technologies to improve shared decision making and patient-provider communication in health care...
  62. Reducing HIV Risk in Adult Women with Intellectual Disabilities
    JENNIFER J WELLS; Fiscal Year: 2012
  63. Randomized Trial of CVD Education and Problem-Solving Training in Urban Diabetics
    Felicia Hill-Briggs; Fiscal Year: 2012
  64. Variation in the Safety of Back Pain-Related Surgery
    Sohail K Mirza; Fiscal Year: 2010
    ..Furthermore, all patients experienced shared decision making ("Informed Choice"), wherein their values and preferences were recorded, a much higher standard of informed ..
  65. Patient Awareness and Consumer Education Research Cente*
    Maria E Suarez Almazor; Fiscal Year: 2010
    ..Publications 2. Research Grants 3. Conceptual Framework &DemonstrationProjects 4. VisionTree Software PHS 398 (Rev. 09/04) Page 4 Form Page 3 ..
  66. Decision-Making about Childhood HPV Vaccination among Low SES Mothers
    TIFFANY FLOYD; Fiscal Year: 2009
    ..Results from this research will be used to inform decision-making interventions for mothers from low SES backgrounds, many of whom may face unique barriers to vaccinating their daughters against HPV. ..
  67. Treatment decision making in older adults newly diagnosed with multiple myeloma
    Joseph D Tariman; Fiscal Year: 2010
    ..The increasing number of treatment options for patients newly diagnosed with myeloma also complicates the decision making process requiring in-depth examination of various factors affecting treatment decisions...
  68. Shared Decision-Making in End-Stage Heart & Lung Disease
    Mark Sullivan; Fiscal Year: 2005
    ..Are there significant differences] How does prognostic understanding and decision making differ between patients with CHF and those with COPD? 2] To generate a grounded theory of end of life ..
  69. Health, Pollution & Economic Development in South Durban
    Stuart Batterman; Fiscal Year: 2004
    ..The study is designed to respond to Durban's needs and serve as a model for other cities undergoing rapid urbanization and industrial development. ..
  70. PGD: Couples Decision Making at the Genetic and Reproductive Interface
    Patricia Hershberger; Fiscal Year: 2009
    ..Despite these far reaching considerations, little is known about the decision making processes of couples surrounding PGD use...
  71. Decision-making in Pelvic Floor Disorders: Translating Outcomes to Practice
    JAMES LEIGH WHITESIDE; Fiscal Year: 2010
    ..Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, The Center for Shared Decision Making, The Dartmouth Institute for Healthy Policy and Clinical Practice and the Tuck School of Business at ..
  72. Clinically enhanced multi-purpose administrative dataset for comparative effectiv
    Hamisu Salihu; Fiscal Year: 2010
    Rick Zimmerman; Fiscal Year: 2001
    ..As a result of these studies, we will determine the impact of impulsivity, sensation-seeking, sexual arousal, and substance use on the sexual decision-making process and consequent HIV risk behaviors. ..
  74. COMT Genotype and Risky Decision Making in HIV and Methamphetamine Dependence
    Mariana Cherner; Fiscal Year: 2010
    ..Findings will add to the understanding of individual differences in response to risk-reduction interventions and have the potential to inform the tailoring of future interventions. ..
  75. Cognitive and Emotional Sources of Wisdom in Decision Making Across the Lifespan
    Eric J Johnson; Fiscal Year: 2012
    ..part of general intelligence that involves knowledge, experience, and expertise-contribute to wisdom in decision making in older adults. This application has two specific goals...
  76. Shared Decision-making in Surgery to Improve Patient Safety and Reduce Liability
    KAREN BARBARA DOMINO; Fiscal Year: 2010
    ..These results will be useful to health systems in making decisions regarding implementation of shared decision-making. ..
  77. Promoting Health Literacy for Colorectal Cancer Screening
    Robert J Volk; Fiscal Year: 2010
    ..long-term goal of this project is to decrease colorectal cancer (CRC) mortality through encouraging informed decision making about routine CRC screening (CRCS)...
  78. Decision Making in Unaffected First-Degree Relatives of Prostate Cancer Patients
    Clement Gwede; Fiscal Year: 2009
    ..brothers and sons) are known to be at increased risk for the disease, yet virtually no screening informed decision making aids have been developed specifically to help these men become informed about the disease and to decide about ..
  79. Decision Making in Patients with Advanced Prostate Cancer
    Randy Jones; Fiscal Year: 2009
    ..decision aid to enhance decision-making skills about cancer treatment, will demonstrate (a) increased quality decision making, (b) decreased decisional conflict, and (c) increased decisional satisfaction...
  80. Communication in Late-stage Cancer: Exploring Hospice Decision
    DEBORAH PEASE WALDROP; Fiscal Year: 2010
    ..mixed qualitative and quantitative data is to generate a deeper understanding of the complexities of hospice decision making. The results will provide information about clinical decisions in "real time" by gathering the experiences of ..
  81. Fertility Decision-Making and Reproductive Health Outcomes in the Era of Antiretr
    SHEREE SCHWARTZ; Fiscal Year: 2009
    ..little evidence or knowledge of whether or not these pregnancies are intended and how the reproductive decision making process is being managed in the treatment era...
  82. Better Decisions, Better Care: Theories of Medical Decision Making and Health
    VALERIE REYNA; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): The Society for Medical Decision Making (SMDM) is dedicated to promoting rigorous, scientific research on health care decisions and policy initiatives...
  83. PNI and Decision Making in Women Diagnosed with DCIS
    LINDA JANUSEK; Fiscal Year: 2007
    ..3) Evaluate a mediation and moderation model of psychological stress and decision making in women diagnosed with DCIS by determining whether: (a) decision making characteristics (decision style, ..
  84. Family Decision Making in Pediatric Bone Marrow Transplant
    Rebecca Pentz; Fiscal Year: 2009
    ..Although, fortunately, life-threatening pediatric diseases are relatively rare, their impact on entire extended families and even communities is immense. ..
  85. Frontal Striatal Activity During Decision Making in Substance Abuse
    Jody Tanabe; Fiscal Year: 2009
    ..of neural circuits, namely cortico-limbic and cortical-striatal systems, that mediate drive, motivation, and decision making. The long term objective of this proposal is to understand the neurobiological mechanisms underlying impaired ..
  86. Better Decisions, Better Care: Advancing decision support to improve health care
    Nananda Col; Fiscal Year: 2006
    DESCRIPTION (provided by the applicant): The Society for Medical Decision Making (SMDM) dedicates its efforts to promoting rigorous, scientific evaluations of health care decisions and health care policy initiatives...
  87. Imaging the fronto-limbic-striatal circuit in adolescent cannabis users
    JOHN CLYBURN CHURCHWELL; Fiscal Year: 2010
    ..The results of the study will contribute to basic knowledge about the neural basis of choice preference in substance abusing adolescents, inform drug prevention strategies, and provide preliminary data for more extensive future proposals ..
  88. Family Decisions About Palliative Care
    Alison Karasz; Fiscal Year: 2004
    ..Current ethical and legal guidelines for family decision making incorporate a deliberative, rational model of decision making which gives priority to patients' individual ..
  89. Dopaminergic modulation of cost/benefit decision making during aging
    Paul Phillips; Fiscal Year: 2009
    ..Is the diminished capacity for dopamine release reflected in the amount of dopamine released during economic decision making? 2) Do these age-related effects contribute to a change in economic decision making? To address these ..
  90. Prostate Cancer Clinical Decision Making by Diagnosed and High Risk Latino Men
    Sally Maliski; Fiscal Year: 2009
    ..will be addressed with in-depth individual interviews exploring involvement in and comfort with treatment decision making process, influences on the decision, and disclosure of diagnosis by treated men...
  91. The functions of affect in treatment decicions of rising PSA patients
    Michael A Diefenbach; Fiscal Year: 2010
    ..All treatments (except for observation) have significant side-effects and will influence quality of life. Decision making in such circumstances is difficult at best...
    KATHERINE FORREST; Fiscal Year: 1993
    ..model; (2) describe the California Hispanic male population with regard to condom use patterns, condom- decision making stages, and relevant personal history, personal quality, and social milieu characteristics; and (3) evaluate ..