touch

Summary

Summary: Sensation or perception by which contact with objects, animate or inanimate, gives evidence as to certain qualities or characteristics.

Top Publications

  1. ncbi Humans integrate visual and haptic information in a statistically optimal fashion
    Marc O Ernst
    Vision Science Program, School of Optometry, University of California, Berkeley 94720 2020, USA
    Nature 415:429-33. 2002
  2. ncbi Coding and use of tactile signals from the fingertips in object manipulation tasks
    Roland S Johansson
    Physiology Section, Department of Integrative Medical Biology, Umea University, SE 901 87 Umea, Sweden
    Nat Rev Neurosci 10:345-59. 2009
  3. ncbi The transcription factor c-Maf controls touch receptor development and function
    Hagen Wende
    Developmental Biology, Max Delbruck Center MDC for Molecular Medicine, Berlin, Germany
    Science 335:1373-6. 2012
  4. ncbi That's my hand! Activity in premotor cortex reflects feeling of ownership of a limb
    H Henrik Ehrsson
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, London WC1N 3BG, UK
    Science 305:875-7. 2004
  5. pmc The sensory neurons of touch
    Victoria E Abraira
    The Solomon H Snyder Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 79:618-39. 2013
  6. ncbi The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals
    ROBERT O'HAGAN
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Nat Neurosci 8:43-50. 2005
  7. pmc Touching a rubber hand: feeling of body ownership is associated with activity in multisensory brain areas
    H Henrik Ehrsson
    Wellcome Department of Cognitive Neurology, Institute of Neurology, London WC1N 3BG, United Kingdom
    J Neurosci 25:10564-73. 2005
  8. ncbi Video ergo sum: manipulating bodily self-consciousness
    Bigna Lenggenhager
    Laboratory of Cognitive Neuroscience, Ecole Polytechnique Federale de Lausanne, Station 15, 1015 Lausanne, Switzerland
    Science 317:1096-9. 2007
  9. ncbi Developmental genetics of the mechanosensory neurons of Caenorhabditis elegans
    M Chalfie
    Dev Biol 82:358-70. 1981
  10. ncbi The rubber hand illusion revisited: visuotactile integration and self-attribution
    Manos Tsakiris
    Institute of Cognitive Neuroscience and Department of Psychology, University College London, London, United Kingdom
    J Exp Psychol Hum Percept Perform 31:80-91. 2005

Detail Information

Publications371 found, 100 shown here

  1. ncbi Humans integrate visual and haptic information in a statistically optimal fashion
    Marc O Ernst
    Vision Science Program, School of Optometry, University of California, Berkeley 94720 2020, USA
    Nature 415:429-33. 2002
    When a person looks at an object while exploring it with their hand, vision and touch both provide information for estimating the properties of the object...
  2. ncbi Coding and use of tactile signals from the fingertips in object manipulation tasks
    Roland S Johansson
    Physiology Section, Department of Integrative Medical Biology, Umea University, SE 901 87 Umea, Sweden
    Nat Rev Neurosci 10:345-59. 2009
    ..Analysis of signals in tactile afferent neurons and central processes in humans reveals how contact events are encoded and used to monitor and update task performance...
  3. ncbi The transcription factor c-Maf controls touch receptor development and function
    Hagen Wende
    Developmental Biology, Max Delbruck Center MDC for Molecular Medicine, Berlin, Germany
    Science 335:1373-6. 2012
    The sense of touch relies on detection of mechanical stimuli by specialized mechanosensory neurons...
  4. ncbi That's my hand! Activity in premotor cortex reflects feeling of ownership of a limb
    H Henrik Ehrsson
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, London WC1N 3BG, UK
    Science 305:875-7. 2004
    ..The neural activity in the premotor cortex reflected the feeling of ownership of the hand. This suggests that multisensory integration in the premotor cortex provides a mechanism for bodily self-attribution...
  5. pmc The sensory neurons of touch
    Victoria E Abraira
    The Solomon H Snyder Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 79:618-39. 2013
    ..The first step leading to perception of innocuous touch is activation of cutaneous sensory neurons called low-threshold mechanoreceptors (LTMRs)...
  6. ncbi The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals
    ROBERT O'HAGAN
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Nat Neurosci 8:43-50. 2005
    Transformation of mechanical energy into ionic currents is essential for touch, hearing and nociception. Although DEG/ENaC proteins are believed to form sensory mechanotransduction channels, the evidence for this role remains indirect...
  7. pmc Touching a rubber hand: feeling of body ownership is associated with activity in multisensory brain areas
    H Henrik Ehrsson
    Wellcome Department of Cognitive Neurology, Institute of Neurology, London WC1N 3BG, United Kingdom
    J Neurosci 25:10564-73. 2005
    ..We propose that this could be the mechanism for the feeling of body ownership...
  8. ncbi Video ergo sum: manipulating bodily self-consciousness
    Bigna Lenggenhager
    Laboratory of Cognitive Neuroscience, Ecole Polytechnique Federale de Lausanne, Station 15, 1015 Lausanne, Switzerland
    Science 317:1096-9. 2007
    ..Our results indicate that spatial unity and bodily self-consciousness can be studied experimentally and are based on multisensory and cognitive processing of bodily information...
  9. ncbi Developmental genetics of the mechanosensory neurons of Caenorhabditis elegans
    M Chalfie
    Dev Biol 82:358-70. 1981
  10. ncbi The rubber hand illusion revisited: visuotactile integration and self-attribution
    Manos Tsakiris
    Institute of Cognitive Neuroscience and Department of Psychology, University College London, London, United Kingdom
    J Exp Psychol Hum Percept Perform 31:80-91. 2005
    ..Conversely, at the level of the phenomenological content, the illusion is modulated by top-down influences originating from the representation of one's own body...
  11. ncbi The neurophysiology of unmyelinated tactile afferents
    Hakan Olausson
    Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
    Neurosci Biobehav Rev 34:185-91. 2010
    ..Since this system is poor in encoding discriminative aspects of touch, but well-suited to encoding slow, gentle touch, CT fibers in hairy skin may be part of a system for processing ..
  12. ncbi Binding of movement, sound and touch: multimodal coordination dynamics
    J Lagarde
    Laboratory Efficience Deficience Motrice, University Montpellier 1, 700 Avenue Pic Saint Loup, 34090 Montpellier, France
    Exp Brain Res 173:673-88. 2006
    Very little is known about the coordination of movement in combination with stimuli such as sound and touch. The present research investigates the hypothesis that both the type of action (e.g...
  13. ncbi A touching sight: SII/PV activation during the observation and experience of touch
    Christian Keysers
    BCN Neuroimaging Centre, University of Groningen, 9713 AW Groningen, The Netherlands
    Neuron 42:335-46. 2004
    ..If a similar mechanism applies to the sight of touch, movies depicting touch should automatically activate the somatosensory cortex of the observer...
  14. ncbi Is that near my hand? Multisensory representation of peripersonal space in human intraparietal sulcus
    Tamar R Makin
    Neurobiology Department, Life Sciences Institute, Hebrew University, Jerusalem 91904, Israel
    J Neurosci 27:731-40. 2007
    ..We therefore suggest that, whereas cortical regions within the posterior IPS and LOC represent hand-centered space in a predominantly visual manner, the anterior IPS uses multisensory information in representing perihand space...
  15. ncbi Spatio-temporal prediction modulates the perception of self-produced stimuli
    S J Blakemore
    Wellcome Department of Cognitive Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    J Cogn Neurosci 11:551-9. 1999
    ..e., its tickliness) is proportional to the error between the sensory feedback predicted by an internal forward model of the motor system and the actual sensory feedback produced by the movement...
  16. ncbi Sparse temporal coding of elementary tactile features during active whisker sensation
    Shantanu P Jadhav
    Computational Neurobiology Graduate Program, University of California, San Diego, La Jolla, California, USA
    Nat Neurosci 12:792-800. 2009
    ..Slips are thus a fundamental encoded tactile feature in natural whisker input streams and are represented by sparse, temporally precise, synchronous spiking in S1...
  17. ncbi The experimental induction of out-of-body experiences
    H Henrik Ehrsson
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, 12 Queen Square, London WC1N 3BG, UK
    Science 317:1048. 2007
    ..This demonstrates that the experience of being localized within the physical body can be determined by the visual perspective in conjunction with correlated multisensory information from the body...
  18. ncbi Superior tactile performance and learning in professional pianists: evidence for meta-plasticity in musicians
    Patrick Ragert
    Institute for Neuroinformatics, Theoretical Biology Ruhr University, D 44780 Bochum, Germany
    Eur J Neurosci 19:473-8. 2004
    ..This implies stronger capacities for plastic reorganization and points to enhanced learning abilities implicating a form of meta-plasticity in professional pianists...
  19. ncbi Neural signatures of body ownership: a sensory network for bodily self-consciousness
    Manos Tsakiris
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, UK
    Cereb Cortex 17:2235-44. 2007
    ..These structures form a network that plays a fundamental role in linking current sensory stimuli to one's own body and thus also in self-consciousness...
  20. pmc Seeing touch is correlated with content-specific activity in primary somatosensory cortex
    Kaspar Meyer
    Brain and Creativity Institute, University of Southern California, 3641 Watt Way, Suite 126, Los Angeles, CA 90089 2520, USA
    Cereb Cortex 21:2113-21. 2011
    ..sensory modality imply features characteristic of a different modality; for instance, visual stimuli that imply touch have been observed to activate the primary somatosensory cortex (SI)...
  21. pmc Projecting sensations to external objects: evidence from skin conductance response
    K Carrie Armel
    Psychology Department, University of California at San Diego, La Jolla, CA 92093 0109, USA
    Proc Biol Sci 270:1499-506. 2003
    Subjects perceived touch sensations as arising from a table (or a rubber hand) when both the table (or the rubber hand) and their own real hand were repeatedly tapped and stroked in synchrony with the real hand hidden from view...
  22. ncbi Kv1.1 channels act as mechanical brake in the senses of touch and pain
    Jizhe Hao
    Aix Marseille Universite, CNRS, Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, UMR 7286, CS80011, Boulevard Pierre Dramard, 13344 Marseille Cedex 15, France
    Neuron 77:899-914. 2013
    ..By balancing the activity of excitatory mechanotransducers, Kv1.1 acts as a mechanosensitive brake that regulates mechanical sensitivity of fibers associated with mechanical perception...
  23. pmc Active touch sensing
    Tony J Prescott
    University of Sheffield Psychology, Western Bank, Sheffield S10 2TN, UK
    Philos Trans R Soc Lond B Biol Sci 366:2989-95. 2011
    ..In animals, active sensing is perhaps most evident in the modality of touch. In this theme issue, we look at active touch across a broad range of species from insects, terrestrial and marine ..
  24. pmc If I were you: perceptual illusion of body swapping
    Valeria I Petkova
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 3:e3832. 2008
    ..Our results are of fundamental importance because they identify the perceptual processes that produce the feeling of ownership of one's body...
  25. ncbi Empathy for pain and touch in the human somatosensory cortex
    Ilaria Bufalari
    Dipartimento di Psicologia, Universita degli Studi di Roma La Sapienza, I 00185, Rome, Italy
    Cereb Cortex 17:2553-61. 2007
    Although feeling pain and touch has long been considered inherently private, recent neuroimaging and neurophysiological studies hint at the social implications of this experience...
  26. ncbi Mechanical characteristics of rat vibrissae: resonant frequencies and damping in isolated whiskers and in the awake behaving animal
    Mitra J Hartmann
    Jet Propulsion Laboratory, California Institute of Technology, Pasadena, California 91109, USA
    J Neurosci 23:6510-9. 2003
    ..We discuss the potential roles of resonance during natural exploratory behavior and specifically suggest that resonant oscillations may be important in the rat's tactile detection of object boundaries...
  27. ncbi Vision modulates somatosensory cortical processing
    Marisa Taylor-Clarke
    Institute of Cognitive Neuroscience and Department of Psychology, University College London, 17, Queen Square, London WC1N 3AR, United Kingdom
    Curr Biol 12:233-6. 2002
    ..To our knowledge, this is the first demonstration of direct modulation of somatosensory cortex activity by a noninformative view of the stimulated body site with concomitant enhancement of tactile acuity in normal subjects...
  28. ncbi Cross-modal plasticity revealed by electrotactile stimulation of the tongue in the congenitally blind
    Maurice Ptito
    PET Centre and CFIN, Aarhus University Hospitals, Aarhus, Denmark
    Brain 128:606-14. 2005
    ..Our data further show that the tongue can act as a portal to convey somatosensory information to visual cortex...
  29. pmc Touch perception reveals the dominance of spatial over digital representation of numbers
    Claudio Brozzoli
    Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche S 864 Espace et Action, F 69500 Bron, France
    Proc Natl Acad Sci U S A 105:5644-8. 2008
    ..1993) J Exp Psychol Genet 122:371-396]. Here, we investigated touch perception to disambiguate whether number representation is embodied on the hand ("1" = thumb; "5" = little finger)..
  30. ncbi Synaptic mechanisms underlying sparse coding of active touch
    Sylvain Crochet
    Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    Neuron 69:1160-75. 2011
    ..Although whisker contact with an object evoked rapid depolarization in all neurons, these touch responses only drove action potentials in ∼10% of the cells...
  31. ncbi Functional relevance of cross-modal plasticity in blind humans
    L G Cohen
    Human Cortical Physiology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1428, USA
    Nature 389:180-3. 1997
    ..We propose that this cross-modal plasticity may account in part for the superior tactile perceptual abilities of blind subjects...
  32. ncbi Vibrissa-based object localization in head-fixed mice
    Daniel H O'Connor
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA
    J Neurosci 30:1947-67. 2010
    ..Mice tended to maximize contact with the go (rewarded) stimulus while minimizing contact with the no-go stimulus. We conjecture that this may amplify differences in evoked neural activity between trial types...
  33. ncbi The mammalian sodium channel BNC1 is required for normal touch sensation
    M P Price
    Howard Hughes Medical Institute, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA
    Nature 407:1007-11. 2000
    Of the vertebrate senses, touch is the least understood at the molecular level The ion channels that form the core of the mechanosensory complex and confer touch sensitivity remain unknown...
  34. pmc Virtual touch tissue quantification of acoustic radiation force impulse: a new ultrasound elastic imaging in the diagnosis of thyroid nodules
    Yi Feng Zhang
    Department of Medical Ultrasound, Tenth People s Hospital of Tongji University, Shanghai, People s Republic of China
    PLoS ONE 7:e49094. 2012
    Virtual touch tissue quantification (VTQ) of acoustic radiation force impulse (ARFI) is a new quantitative technique to measure tissue stiffness. The study was aimed to assess the usefulness of VTQ in the diagnosis of thyroid nodules.
  35. pmc Finger pad friction and its role in grip and touch
    Michael J Adams
    School of Chemical Engineering, University of Birmingham, Birmingham B15 2TT, UK
    J R Soc Interface 10:20120467. 2013
    ..is well established that friction plays a crucial role in grip function, its exact contribution for discriminatory touch involving the sliding of a finger pad is more elusive...
  36. ncbi From part- to whole-body ownership in the multisensory brain
    Valeria I Petkova
    Brain, Body and Self Laboratory, Department of Neuroscience, Karolinska Institutet, Retzius vag 8, SE 171 77 Stockholm, Sweden
    Curr Biol 21:1118-22. 2011
    ..These findings suggest that the unitary experience of owning an entire body is produced by neuronal populations that integrate multisensory information across body segments...
  37. pmc Merkel cells are essential for light-touch responses
    Stephen M Maricich
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Science 324:1580-2. 2009
    The peripheral nervous system detects different somatosensory stimuli, including pain, temperature, and touch. Merkel cell-neurite complexes are touch receptors composed of sensory afferents and Merkel cells...
  38. pmc Lateral facilitation between primary mechanosensory neurons controls nose touch perception in C. elegans
    Marios Chatzigeorgiou
    Cell Biology Division, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Neuron 70:299-309. 2011
    The nematode C. elegans senses head and nose touch using multiple classes of mechanoreceptor neurons that are electrically coupled through a network of gap junctions...
  39. ncbi Vicarious responses to social touch in posterior insular cortex are tuned to pleasant caressing speeds
    India Morrison
    Department of Clinical Neurophysiology, Sahlgrenska University Hospital, S 413 45 Gothenburg, Sweden
    J Neurosci 31:9554-62. 2011
    Affective touch carries strong significance for social mammals, including humans...
  40. ncbi Embodied empathy for tactile events: Interindividual differences and vicarious somatosensory responses during touch observation
    Michael Schaefer
    Department of Neurology, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany
    Neuroimage 60:952-7. 2012
    ..For example, it has been shown that observing touch on other bodies (in the absence of any real touch on the own body) affects somatosensory brain areas...
  41. ncbi Discriminative touch and emotional touch
    Francis McGlone
    University of Liverpool
    Can J Exp Psychol 61:173-83. 2007
    ..so widely recognized as also providing the subjective experience of affiliative or emotional somatic pleasure of touch. The discriminative properties of tactile sensation are mediated by a class of fast-conducting myelinated ..
  42. pmc A dual mechanosensory and chemosensory neuron in Caenorhabditis elegans
    J M Kaplan
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Proc Natl Acad Sci U S A 90:2227-31. 1993
    After light touch to its nose, the nematode Caenorhabditis elegans halts forward locomotion and initiates backing...
  43. ncbi KCNQ4 K(+) channels tune mechanoreceptors for normal touch sensation in mouse and man
    Matthias Heidenreich
    Leibniz Institut fur Molekulare Pharmakologie, Berlin, Germany
    Nat Neurosci 15:138-45. 2012
    ..This work describes a gene mutation that modulates touch sensitivity in mice and humans and establishes KCNQ4 as a specific molecular marker for rapidly adapting Meissner ..
  44. pmc From maps to form to space: touch and the body schema
    Jared Medina
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychologia 48:645-54. 2010
    ....
  45. ncbi Assessment of vibrotactile feedback on postural stability during pseudorandom multidirectional platform motion
    Kathleen H Sienko
    Department ofMechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
    IEEE Trans Biomed Eng 57:944-52. 2010
    ..However, the spatial resolution of the tactor displays did not affect subjects' performance, thereby supporting the use of a lower spatial resolution display in future device designs...
  46. pmc Anticipatory planning and control of grasp positions and forces for dexterous two-digit manipulation
    Qiushi Fu
    Department of Kinesiology, Arizona State University, Tempe, Arizona 85287 0404, USA
    J Neurosci 30:9117-26. 2010
    ..These results are discussed in the context of motor equivalence and sensorimotor integration of grasp kinematics and kinetics...
  47. ncbi MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation
    Miriam B Goodman
    Department of Biological Sciences, Columbia University, New York 10027, USA
    Nature 415:1039-42. 2002
    b>Touch sensitivity in animals relies on nerve endings in the skin that convert mechanical force into electrical signals...
  48. ncbi P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury
    Makoto Tsuda
    Division of Biosignaling, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya, Tokyo 158 8501, Japan
    Nature 424:778-83. 2003
    ..Thus, blocking P2X4Rs in microglia might be a new therapeutic strategy for pain induced by nerve injury...
  49. pmc Beyond sensory images: Object-based representation in the human ventral pathway
    Pietro Pietrini
    Laboratory of Clinical Biochemistry, Department of Experimental Pathology, University of Pisa Medical School, I 56126 Pisa, Italy
    Proc Natl Acad Sci U S A 101:5658-63. 2004
    ..These results demonstrate that the representation of objects in the ventral visual pathway is not simply a representation of visual images but, rather, is a representation of more abstract features of object form...
  50. ncbi Encoding of direction of fingertip forces by human tactile afferents
    I Birznieks
    Department of Integrative Medical Biology, Physiology Section, Umea University, SE 901 87 Umea, Sweden
    J Neurosci 21:8222-37. 2001
    ..We conclude that tactile afferents from the whole terminal phalanx potentially contribute to the encoding of direction of fingertip forces similar to those that occur when subjects manipulate objects under natural conditions...
  51. ncbi Differential activation in somatosensory cortex for different discrimination tasks
    C Braun
    Institute of Medical Psychology and Behavioral Neurobiology, University of Tubingen, D 72074 Tubingen, Germany
    J Neurosci 20:446-50. 2000
    ....
  52. pmc Psychologically induced cooling of a specific body part caused by the illusory ownership of an artificial counterpart
    G Lorimer Moseley
    Department of Physiology, Anatomy and Genetics, Oxford University, Oxford OX1 3QX, United Kingdom
    Proc Natl Acad Sci U S A 105:13169-73. 2008
    ....
  53. ncbi The effect of visual experience on the development of functional architecture in hMT+
    Emiliano Ricciardi
    Laboratory of Clinical Biochemistry and Molecular Biology, Department of Experimental Pathology, Medical Biotechnologies, Infectivology, and Epidemiology, University of Pisa Medical School, I 56126 Pisa, Italy
    Cereb Cortex 17:2933-9. 2007
    ....
  54. pmc Neuronal activity in rat barrel cortex underlying texture discrimination
    Moritz von Heimendahl
    Cognitive Neuroscience Sector, International School for Advanced Studies, Trieste, Italy
    PLoS Biol 5:e305. 2007
    ..In conclusion, these data suggest that barrel cortex firing rate on each trial leads directly to the animal's judgment of texture...
  55. ncbi The cutaneous sensory system
    Francis McGlone
    Dept of Neurological Science, University of Liverpool, Clinical Sciences Centre for Research and Education, Lower Lane, Liverpool L9 7LJ, UK
    Neurosci Biobehav Rev 34:148-59. 2010
    ..is growing evidence for the presence of a fifth modality that conveys positive affective (pleasant) properties of touch. Cutaneous sensory channels can be further classified as serving predominantly either discriminative or affective ..
  56. ncbi Encoding of whisker vibration by rat barrel cortex neurons: implications for texture discrimination
    Ehsan Arabzadeh
    Cognitive Neuroscience Sector, International School for Advanced Studies, 34014 Trieste, Italy
    J Neurosci 23:9146-54. 2003
    ..We conclude that vibration kinetics are rapidly and reliably encoded in the firing rate of cortical ensembles. Therefore, the cortical representation of vibration speed could underlie texture discrimination...
  57. ncbi The sense of touch: embodied simulation in a visuotactile mirroring mechanism for observed animate or inanimate touch
    Sjoerd J H Ebisch
    Department of Clinical Sciences and Bioimaging, G D Annunzio University, Chieti, Italy
    J Cogn Neurosci 20:1611-23. 2008
    ..in the somatosensory cortices for the experience of one's own body being touched and the sight of intentional touch. Using functional magnetic resonance imaging (fMRI), the present study aimed to elucidate whether the activation ..
  58. ncbi Multisensory integration in the ventral intraparietal area of the macaque monkey
    Marie Avillac
    Institut des Sciences Cognitives, Centre National de la Recherche Scientifique, Universite de Lyon 1, F 69675 Bron, France
    J Neurosci 27:1922-32. 2007
    ..g., spatial congruency and temporal synchrony) that are closely similar to those described in other cortical and subcortical regions...
  59. pmc Pickpocket is a DEG/ENaC protein required for mechanical nociception in Drosophila larvae
    Lixian Zhong
    Pharmacology Science Training Program, Duke University Medical Center, Durham, NC 27710, USA
    Curr Biol 20:429-34. 2010
    ..However, pickpocket mutants display normal behavioral responses to gentle touch. Tissue-specific knockdown of pickpocket in nociceptors phenocopies the mechanical nociception impairment without ..
  60. pmc Integration of visual and tactile signals from the hand in the human brain: an FMRI study
    Giovanni Gentile
    Brain, Body and Self Laboratory, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Neurophysiol 105:910-22. 2011
    ..These results identify a set of candidate frontal, parietal and subcortical regions that integrate visual and tactile information for the multisensory perception of one's own hand...
  61. pmc Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling
    Wenqin Luo
    Solomon H Snyder Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
    Neuron 64:841-56. 2009
    ..Thus, the early Ret(+) neurons are RA mechanoreceptors and Ret signaling is required for the assembly of neural circuits underlying touch perception.
  62. ncbi Critical period for cross-modal plasticity in blind humans: a functional MRI study
    Norihiro Sadato
    National Institute for Physiological Sciences, Okazaki, Japan
    Neuroimage 16:389-400. 2002
    ..Instead, the visual association cortex may mediate the circuitry by which V1 is activated during tactile stimulation...
  63. pmc Mammalian somatosensory mechanotransduction
    Makoto Tsunozaki
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, USA
    Curr Opin Neurobiol 19:362-9. 2009
    In the mammalian somatosensory system, mechanosensitive neurons mediate the senses of touch and pain. Among sensory modalities, mechanosensation has been the most elusive with regard to the identification of transduction molecules...
  64. ncbi Pacinian representations of fine surface texture
    Sliman Bensmaïa
    University of North Carolina, Chapel Hill, North Carolina, USA
    Percept Psychophys 67:842-54. 2005
    ..Our results further suggested that the textural information conveyed by the Pacinian system concerns surface roughness and, possibly, stickiness...
  65. pmc The cell biology of touch
    Ellen A Lumpkin
    Department of Dermatology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Cell Biol 191:237-48. 2010
    The sense of touch detects forces that bombard the body's surface...
  66. ncbi Neural synergy between kinetic vision and touch
    Randolph Blake
    Vanderbilt Vision Research Center, Vanderbilt University, Nashville, TN 37203, USA
    Psychol Sci 15:397-402. 2004
    ..This disambiguation of vision by touch occurs only when the two modalities are stimulated concurrently, however...
  67. pmc Neurotransmitters and synaptic components in the Merkel cell-neurite complex, a gentle-touch receptor
    Srdjan Maksimovic
    Department of Dermatology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Ann N Y Acad Sci 1279:13-21. 2013
    ..Most make contacts with somatosensory afferents to form Merkel cell-neurite complexes, which are gentle-touch receptors that initiate slowly adapting type I responses...
  68. ncbi Pleasantness of touch in human glabrous and hairy skin: order effects on affective ratings
    Line S Löken
    Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
    Brain Res 1417:9-15. 2011
    The tactile sense comprises pathways for both discriminative and affective touch. Low threshold unmyelinated mechanoafferents (C tactile, CT) in the human hairy skin have recently been linked to pleasant touch sensation...
  69. ncbi Tactile acuity is enhanced in blindness
    Daniel Goldreich
    Department of Occupational Therapy, Rangos School of Health Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, USA
    J Neurosci 23:3439-45. 2003
    ..The results suggest that crossmodal plasticity may underlie tactile acuity enhancement in blindness...
  70. ncbi Light touch contact as a balance aid
    J J Jeka
    Department of Kinesiology, College of Health and Human Performance, University of Maryland at College Park 20742 2611, USA
    Phys Ther 77:476-87. 1997
    ..Clinicians, however, often observe patients with poor balance control using light touch of surrounding objects and surfaces to stabilize themselves while standing and walking...
  71. pmc C. elegans multi-dendritic sensory neurons: morphology and function
    Adi Albeg
    Department of Medical Neurobiology, Institute for Medical Research Israel Canada, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Mol Cell Neurosci 46:308-17. 2011
    ..Based on all these results we suggest that noxious signals perceived by PVD and FLP promote an escape behavior consisting of increased speed, reduced pauses and reversals, and inhibition of egg-laying...
  72. ncbi Quantitative assessment of pleasant touch
    Greg K Essick
    Department of Prosthodontics and Center for Neurosensory Disorders, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7450, USA
    Neurosci Biobehav Rev 34:192-203. 2010
    ..However, the difficulty in making further general statements regarding hedonic touch raises questions as to whether the body surface can be mapped affectively in a meaningful manner with a single ..
  73. ncbi 3-D finite-element models of human and monkey fingertips to investigate the mechanics of tactile sense
    Kiran Dandekar
    Touch Lab, Department of Mechanical Engineering, Research Laboratory of Electronics, Massachusetts Institute of Technology, 50 Vassar Street, Cambridge, MA 02139, USA
    J Biomech Eng 125:682-91. 2003
    The biomechanics of skin and underlying tissues plays a fundamental role in the human sense of touch. It governs the mechanics of contact between the skin and an object, the transmission of the mechanical signals through the skin, and ..
  74. pmc Light touch induces ERK activation in superficial dorsal horn neurons after inflammation: involvement of spinal astrocytes and JNK signaling in touch-evoked central sensitization and mechanical allodynia
    Yong Jing Gao
    Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurochem 115:505-14. 2010
    ..Interestingly, low-threshold mechanical stimulation given by light touch either on the inflamed paw or the contralateral non-inflamed paw dramatically increased ERK phosphorylation in the ..
  75. ncbi Closing an open-loop control system: vestibular substitution through the tongue
    Mitchell Tyler
    Wicab, Inc, 3510 W Beltline Hwy, Middleton, WI 53562, USA
    J Integr Neurosci 2:159-64. 2003
    ..Moreover, postural stability persists for a period of time after removing the vestibular substitution, after which the open-loop instability reappears...
  76. ncbi A Drosophila mechanosensory transduction channel
    R G Walker
    Department of Biology, Howard Hughes Medical Institute, University of California, San Diego, CA 92093 0649, USA
    Science 287:2229-34. 2000
    Mechanosensory transduction underlies a wide range of senses, including proprioception, touch, balance, and hearing...
  77. ncbi An event-related brain potential study of cross-modal links in spatial attention between vision and touch
    M Eimer
    Department of Psychology, Birkbeck College, University of London, England
    Psychophysiology 37:697-705. 2000
    ..potential (ERP) evidence for the existence of cross-modal links in endogenous spatial attention between vision and touch was obtained in an experiment where participants had to detect tactile or visual targets on the attended side and ..
  78. ncbi My face in yours: Visuo-tactile facial stimulation influences sense of identity
    Anna Sforza
    Sapienza University of Rome and Fondazione Santa Lucia IRCCS, Rome, Italy
    Soc Neurosci 5:148-62. 2010
    ..Thus, personality variables modulate enfacement, which may represent a marker of the tendency to be social and may be absent in subjects with defective empathy...
  79. ncbi Importance of cutaneous feedback in maintaining a secure grip during manipulation of hand-held objects
    Anne Sophie Augurelle
    Unite de Readaptation et de medecine physique, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    J Neurophysiol 89:665-71. 2003
    ..Finally, at a more theoretical level, they correct and maintain an internal model of the physical properties of hand-held objects...
  80. ncbi Behavioural report of single neuron stimulation in somatosensory cortex
    Arthur R Houweling
    Bernstein Center for Computational Neuroscience and Humboldt University Berlin, Philippstrasse 13, House 6, 10115 Berlin, Germany
    Nature 451:65-8. 2008
    ..Our results demonstrate that single neuron activity can cause a change in the animal's detection behaviour, suggesting a much sparser cortical code for sensations than previously anticipated...
  81. ncbi The role of hand size in the fake-hand illusion paradigm
    Francesco Pavani
    Dipartimento di Scienze della Cognizione e della Formazione and Centro Interdipartimentale Mente e Cervello CIMeC, Universita di Trento, Corso Bettini 31, I 38068 Rovereto, Italy
    Perception 36:1547-54. 2007
    ..In addition, they suggest an asymmetric tendency to acknowledge enlarged (but not reduced) images of body parts within our body representation...
  82. ncbi The effect of tactile and visual sensory inputs on phantom limb awareness
    Judith P Hunter
    Toronto Western Research Institute, Toronto Western Hospital, University Health Network, Ontario, Canada
    Brain 126:579-89. 2003
    ..e. these amputees perceived these touch stimuli as if they were being applied both to the stimulus site and also to a location on the missing limb...
  83. ncbi Analysis of haptic perception of materials by multidimensional scaling and physical measurements of roughness and compressibility
    Wouter M Bergmann Tiest
    Helmholtz Institute, Utrecht University, Princetonplein 5, 3584 CC Utrecht, The Netherlands
    Acta Psychol (Amst) 121:1-20. 2006
    ..The relation between objective and perceived compressibility and that between objective and perceived roughness could be described by an exponential function...
  84. ncbi Observing touch activates human primary somatosensory cortex
    Elina Pihko
    Brain Research Unit, Low Temperature Laboratory, Aalto University School of Science and Technology, 00076 Aalto, Espoo, Finland
    Eur J Neurosci 31:1836-43. 2010
    ..to show that the human primary somatosensory (SI) cortex is activated by mere observation of touch. Somatosensory evoked fields were measured from adult human subjects in two conditions...
  85. pmc Temperature- and touch-sensitive neurons couple CNG and TRPV channel activities to control heat avoidance in Caenorhabditis elegans
    Shu Liu
    Laboratory for Bioinformatics and Molecular Genetics, Faculty of Biology, Albert Ludwigs University of Freiburg, Freiburg, Germany
    PLoS ONE 7:e32360. 2012
    ..In this work, we investigate neurological and molecular aspects of thermonociception using genetic, cell biological and physiological approaches...
  86. ncbi Spatial limits on referred touch to an alien limb may reflect boundaries of visuo-tactile peripersonal space surrounding the hand
    Donna M Lloyd
    School of Psychological Sciences, The University of Manchester, Zochonis Building, Brunswick Street, Oxford Rd, Manchester, M13 9PL, UK
    Brain Cogn 64:104-9. 2007
    In this study, the spatial limits of referred touch to a rubber hand were investigated...
  87. ncbi Object localization with whiskers
    Ehud Ahissar
    The Department of Neurobiology, Weizmann Institute for Science, Rehovot 76100, Israel
    Biol Cybern 98:449-58. 2008
    ..Such decoding reduces ambiguity, and simplifies the required decoding algorithms, since different readout circuits can be optimized for a particular variable...
  88. pmc Genetic analysis of age-dependent defects of the Caenorhabditis elegans touch receptor neurons
    Chun Liang Pan
    Ernest Gallo Clinic and Research Center and Department of Neurology, University of California, San Francisco, Emeryville, CA 94608, USA
    Proc Natl Acad Sci U S A 108:9274-9. 2011
    ..Here we show that Caenorhabditis elegans touch receptor and cholinergic neurons display age-dependent morphological defects, including cytoskeletal ..
  89. ncbi Acoustic Radiation Force Impulse (ARFI) technique in ultrasound with Virtual Touch tissue quantification of the upper abdomen
    A Gallotti
    Istituto di Radiologia, Policlinico GB Rossi, Universita di Verona, Piazzale LA Scuro 10, 37134 Verona, Italy
    Radiol Med 115:889-97. 2010
    Virtual Touch tissue quantification is an implementation of ultrasound (US) Acoustic Radiation Force Impulse (ARFI) imaging that provides numerical measurements (wave-velocity values) of tissue stiffness...
  90. pmc Vision-based finger detection, tracking, and event identification techniques for multi-touch sensing and display systems
    Yen Lin Chen
    Department of Computer Science and Information Engineering, National Taipei University of Technology, 1, Sec 3, Chung Hsiao E Rd, Taipei 10608, Taiwan
    Sensors (Basel) 11:6868-92. 2011
    ..finger detection, tracking, and event identification techniques and a low-cost hardware framework for multi-touch sensing and display applications...
  91. pmc Primary somatosensory cortex discriminates affective significance in social touch
    Valeria Gazzola
    Department of Neuroscience, University Medical Center Groningen, 9713 AW Groningen, The Netherlands
    Proc Natl Acad Sci U S A 109:E1657-66. 2012
    ..How much the primary somatosensory cortices (SIs) participate in processing the pleasantness of such social touch remains unclear...
  92. ncbi The basal ganglia are hyperactive during the discrimination of tactile stimuli in writer's cramp
    M Peller
    Department of Neurology, Christian Albrechts University Kiel, Kiel, Germany
    Brain 129:2697-708. 2006
    ..Regional activity in these areas may reflect secondary adaptive reorganization at the systems level to compensate for the dysfunction in the basal ganglia-thalamic loop...
  93. pmc The DEG/ENaC protein MEC-10 regulates the transduction channel complex in Caenorhabditis elegans touch receptor neurons
    Johanna Arnadottir
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Neurosci 31:12695-704. 2011
    Gentle touch sensation in Caenorhabditis elegans is mediated by the MEC-4/MEC-10 channel complex, which is expressed exclusively in six touch receptor neurons (TRNs)...
  94. ncbi Localization of sensorimotor cortical rhythms induced by tactile stimulation using spatially filtered MEG
    William Gaetz
    Department of Diagnostic Imaging, Neuromagnetic Imaging Laboratory, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Neuroimage 30:899-908. 2006
    ....
  95. ncbi Vision of the body modulates somatosensory intracortical inhibition
    Flavia Cardini
    Centro Studi e Ricerche in Neuroscienze Cognitive, University of Bologna, Cesena 47023, Italy
    Cereb Cortex 21:2014-22. 2011
    ..These results demonstrate that vision enhances somatosensation by modulating activity of inhibitory interneuronal circuits in the somatosensory cortex...
  96. ncbi Beyond sensory substitution--learning the sixth sense
    Saskia K Nagel
    Institute of Cognitive Science, Albrechtstr 28, Universitat Osnabruck, 49069 Osnabruck, Germany
    J Neural Eng 2:R13-26. 2005
    ..These data support the hypothesis that new sensorimotor contingencies can be learned and integrated into behaviour and affect perceptual experience...
  97. ncbi Effects of repetitive electrical stimulation to treat sensory loss in persons poststroke
    Patricia S Smith
    Department of Physical Therapy, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Arch Phys Med Rehabil 90:2108-11. 2009
    ..Smith PS, Dinse HR, Kalisch T, Johnson M, Walker-Batson D. Effects of repetitive electrical stimulation to treat sensory loss in persons poststroke...
  98. ncbi Three-dimensional analyses of touch domes in the hairy skin of the cat paw reveal morphological substrates for complex sensory processing
    Satomi Ebara
    Department of Anatomy, Meiji University of Oriental Medicine, Kyoto, Japan
    Neurosci Res 61:159-71. 2008
    The three-dimensional morphology of the innervation of touch domes in the hairy skin folds of cat forepaws was investigated by the confocal laser scanning microscopic analyses of sections stained immunocytochemically with primary ..
  99. ncbi Tactile motion activates the human middle temporal/V5 (MT/V5) complex
    Matthew C Hagen
    Cognitive Neuroimaging Unit 11P, Psychiatry Service, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    Eur J Neurosci 16:957-64. 2002
    ..These results suggest involvement of the hMT/V5 complex in tactile motion processing...
  100. ncbi Proprioceptive alignment of visual and somatosensory maps in the posterior parietal cortex
    Nadia Bolognini
    Department of Psychology, University of Milano Bicocca, 20126 Milan, Italy
    Curr Biol 17:1890-5. 2007
    A touch on one hand can enhance the response to a visual stimulus delivered at a nearby location [1, 2], improving our interactions with the external world...
  101. ncbi The brain's fingers and hands
    Patrick Haggard
    Institute of Cognitive Neuroscience and Department of Psychology, University College London, Alexandra House, London, UK
    Exp Brain Res 172:94-102. 2006
    ..This assignment is based on external spatial location. Our results suggest a role of the body schema in the identification of structural body parts from touch.

Research Grants80

  1. Transcription factors regulating sensory gene expression and pain pathways
    Eric E Turner; Fiscal Year: 2011
    ..neurons of the trigeminal and dorsal root ganglia, which are the gatekeepers for the reception of position, touch, and pain signals throughout the body, conveyed by proprioceptors, mechanoreceptors, and nociceptors, respectively...
  2. Developing Physics-Based Virtual Simulation Technology for Natural Orifice Transl
    DANIEL BOUGERE JONES; Fiscal Year: 2013
    ..devices, we propose to develop the first virtual reality (VR)-based NOTES simulator with both visual and haptic (touch) feedback...
  3. UNDERSTANDING VIBRATION INJURY
    Danny A Riley; Fiscal Year: 2013
    ..and the functional deficits related to loss of feeling and muscle weakness (nerve conduction velocity, von Frey touch perception, thermal sensitivity, and cold immersion provocation rewarming and return of blood flow)...
  4. Pathophysiology and Animal Model of Restless Legs Syndrome (RLS): Btbd9 Null Mic
    Yuqing Li; Fiscal Year: 2010
    ..affects sensory system, we will measure the pain threshold using tail flick and hot plate assays, and sense of touch using Von Frey fibers...
  5. Merkel cells specify innervating SAI sensory neuron phenotype.
    Erin G Reed-Geaghan; Fiscal Year: 2013
    ..somatosensory system processes information that organisms "feel", such as pain, pressure, temperature, and touch. Detection of points, edges, and curvature is mediated by the Merkel cell neurite complex...
  6. New mechanism and regulation of intracellular heme delivery in mammals
    Dennis J Stuehr; Fiscal Year: 2013
    ..Our findings will touch many aspects of human health and disease, including blood formation, drug response, anemia, and inflammation.
  7. Intra vs. extracortical command signals to restore six dimensional hand movements
    DAWN MARIE TAYLOR; Fiscal Year: 2012
    ..Many command options, such as voice commands, tongue-touch keypads, or chin- operated joysticks, can be awkward and can interfere with talking, eating, and normal social ..
  8. Unifying Mechanisms of Neurological Disorders: Scientific, Translational, and Cli
    JOAN MARIE CRANMER; Fiscal Year: 2010
    ..Each conference has its own "special touch" unique to the venue and consists of Tutorials, Symposia, Platform Sessions, -Workshops, Panel Discussions, ..
  9. REGULATORY INTERACTIONS BETWEEN TUMOR VIRUSES AND CELLS
    Michael R Botchan; Fiscal Year: 2013
    ..How the different DNA binding factors touch DNA at different sites will be explored...
  10. CGRP-induced light aversion in a preclinical migraine model
    Andrew F Russo; Fiscal Year: 2013
    ..Nestin/hRAMP1 mice have heightened responses to at least two sensory stimuli: touch and light...
  11. Alternate pore isoforms of a mechanotransducing ion channel
    Maurice J Kernan; Fiscal Year: 2013
    ..mechanotransduction is the conversion of mechanical stimuli to cellular potentials: it underlies our senses of touch, hearing, balance and proprioception...
  12. A New Device for Rapid Measurement of Touch Sensation in neuropathy
    Donald A Simone; Fiscal Year: 2010
    ..sensory dysfunction almost always begins in the distal extremities (fingers or toes) where the sensation of touch is diminished or lost...
  13. Identification, Development and Function of Rapidly Adapting Mechanoreceptors
    Wenqin Luo; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Touch sensation, including the perception of form and texture, is essential for our daily lives...
  14. Mission Reconnect: Promoting Resilience and Re-Integration of Post-Deployment Vet
    WILLIAM B COLLINGE; Fiscal Year: 2010
    ..practice to promote interpersonal connectedness with a relationship partner, and (4) instruction in simple touch and massage techniques to promote both stress reduction and interpersonal connectedness...
  15. Role of ultraviolet radiation in Merkel cell carcinogenesis
    David M Owens; Fiscal Year: 2012
    ..This progenitor cell population resides in touch domes in the hairy skin and is unique in its capacity to maintain normal Merkel cell turnover...
  16. Massage to reduce intrauterine artery resistance, prematurity and low birthweight
    MIGUEL ANGEL DIEGO; Fiscal Year: 2012
    ..weeks gestation and randomly assigned to a moderate pressure massage therapy or to a SHAM light pressure massage touch/attention control group...
  17. Receptor Selective Spinal Analgesia
    James Eisenach; Fiscal Year: 2013
    ..recordings from sensory nerves will be made in anesthetized animals to first understand whether pain from light touch after injury is due to an abnormal signal from them...
  18. Functional protein-lipid interactions for the mechanosensitive channel MscS
    JUANDELL LATRICE PARKER; Fiscal Year: 2012
    ..Mechanosensation is used in the senses of touch and balance as well as blood pressure and osmo-regulation...
  19. Antibacterial, antifungal, antiviral, and antispore paints
    YUYU contact SUN; Fiscal Year: 2011
    ..If successful, this technology will provide an innovative approach to protect high-touch, high-risk surfaces in a wide range of applications, which will have a broad and significant impact on health...
  20. 7th World Congress on Itch (WCI)
    Ethan A Lerner; Fiscal Year: 2013
    ..unreadable]Mechanisms-based classification of itch [unreadable]Sensory modalities related to itch, including touch [unreadable]Itch in HIV, kidney, liver disease and cancer [unreadable]Neuropathic itch [unreadable]Peripheral ..
  21. Molecular mechanisms in controlling development of touch-sensing neurons
    Wenqin Luo; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Touch sensation, which is essential for our daily life, social interactions and sexual behaviors, is mediated by mechanosensory neurons within the trigeminal (TG) and dorsal root ganglion (DRG)...
  22. A Lassa Vaccine in primates with AIDS
    Maria Salvato; Fiscal Year: 2009
    ..These studies will touch on a broader issue that arose recently when 3 organ transplant recipients died due to LCMV infection of the ..
  23. Mechanisms of Sensory Modulation of Aging in Drosophila
    Scott D Pletcher; Fiscal Year: 2013
    ..four of them, each linked with one of the four elements - vision with water, sound with air, smell with fire, and touch with earth. Since that time we have become aware of many more, including those involving position or pain...
  24. Allelic Choice in Rett Syndrome
    Mary E Donohoe; Fiscal Year: 2013
    ..Prior to a choice of X chromosome to be inactivated, the two female X chromosomes transiently touch to set a mutually exclusive designation of active versus inactive X chromosome...
  25. Peripheral Mechanisms Governing Tactile Encoding During Normal Target Remodeling
    Ellen A Lumpkin; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Touch is integral to essential behaviors such as feeding, social bonding and avoiding bodily harm. In mammals, touch is encoded by sensory receptors embedded in the skin...
  26. Development of Personalized Assistive Technology to Improve Dementia Care at Home
    CHANTAL M F E KERSSENS; Fiscal Year: 2012
    ..Currently, the Companion is a stationary all-in-one computer touch screen that delivers personalized care interventions ('care shows') to PWD in assisted living and ..
  27. Force Clamp Systems for Evaluation of Mechanotransduction
    BETH L PRUITT; Fiscal Year: 2013
    ..goal of this research is to discover the force transmission and force transduction pathways responsible for touch and proprioception...
  28. Identification, Development and Function of Rapidly Adapting Mechanoreceptors
    Wenqin Luo; Fiscal Year: 2013
    b>Touch sensation, including the perception of form and texture, is essential for our daily lives...
  29. Proteolysis of Myelin as a Source of Neuropathic Pain
    Tony L Yaksh; Fiscal Year: 2013
    ..b>Touch is signaled by non-nociceptive large myelinated (Ab) afferents, which after injury begin interpreting light touch ..
  30. OMX BLAZE High Speed Super Resolution Imaging System
    Aaron F Straight; Fiscal Year: 2012
    ..vesicle docking and fusion (Pfeffer);development of neural synapses (Shen);mechano-electrical transduction in touch receptor neurons (Goodman);recombination and genetic engineering (Porteus);Hedgehog pathway signaling in ..
  31. Biophysics Cell Membrane Probe
    William E Brownell; Fiscal Year: 2010
    ..While the obvious beneficiaries of the instrument will be the hard of hearing and individuals with touch disorders, solutions for other clinical problems will undoubtedly arise because every cell and the organelles ..
  32. Image analysis for high-throughput C. elegans infection and metabolism assays
    CAROLINA EWA ASA WAHLBY; Fiscal Year: 2013
    ..elegans in order to identify and mea- sure individual worms even when the animals touch or cross...
  33. NEURAL MECHANISMS OF CUTANEOUS SPATIAL INTEGRATION
    Esther P Gardner; Fiscal Year: 2012
    ..It aims to understand how information about objects is acquired by the hand through the senses of touch, proprioception, and vision. We propose that sensory responses are perceived in the context of task goals...
  34. Optimizing communication devices for children with dyskinetic cerebral palsy
    Terence D Sanger; Fiscal Year: 2012
    ..dyskinetic cerebral palsy (CP and severe arm movement disorders, devices such as adapted keyboards, programmable touch-screens, and joystick interfaces may be their most important communication link to their families, friends, ..
  35. Dysfunction of sodium homeostasis in a rat migraine model
    MICHAEL GORDON HARRINGTON; Fiscal Year: 2013
    ..Moreover, we found rats in this model have increased sensitivity to touch and light that are similar to migraine symptoms...
  36. Identification of transcriptional determinants of dendritic patterning
    David M Miller; Fiscal Year: 2010
    ..The PVDs respond to strong mechanical force ("harsh touch") to trigger a withdrawal reflex, a behavior indicative of nociceptive function...
  37. MAGNETIC RESONANCE ELASTOGRAPHY
    Richard L Ehman; Fiscal Year: 2013
    ..Unfortunately, palpation is a subjective technique and small or inaccessible abnormalities cannot be detected by touch. Conventional imaging methods such as ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI) ..
  38. Accessibility solutions for PRO management
    DERSHUNG YANG; Fiscal Year: 2010
    ..g., Web, touch-screen, speech/voice, and phone) via personal interviews and an iterative user-centric design process;and 2) the ..
  39. Role of IG CDR-H3 in Responses to HIV Vaccines
    HARRY WILLIAM SCHROEDER; Fiscal Year: 2013
    ..Our studies also touch on "Modulating and/or specifically suppressing component aspects of the immune response to alter disease ..
  40. The role of Atoh1 in the development and function of Merkel cells
    Stephen M Maricich; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Disruptions of the sense of touch are inherent to many inherited and acquired human disorders that affect the skin and/or peripheral nervous system...
  41. Synaptic Transmission In Mammalian Cutaneous Touch Receptors
    Srdjan Maksimovic; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The importance of touch is undeniable: it is an essential sense for our survival that allows us to navigate the physical world...
  42. A Novel Multiplexed Assay for Rapid Antibody Screening
    SCOTT ALLEN MONSMA; Fiscal Year: 2011
    ..standardized analysis and reporting of data from assays run on the Spots on Dots" platform in a rapid, 'one touch'format...
  43. Functional Adaptation of Microtubules by Acetylation
    Jacek Gaertig; Fiscal Year: 2013
    ..This protein is an ortholog of MEC-17, a previously studied protein which is required for the function of touch receptor neurons in C. elegans. We show that MEC-17 mediates acetylation of K40 on 1- tubulin in vitro...
  44. A Measurement-to-Management Tool to Improve Dementia Care
    TONY XUYEN MA; Fiscal Year: 2010
    ..of the Phase II project include developing and evaluating user-friendly software and procedures on the iPod Touch Platform to collect and manage QOL data and produce care-relevant information;and evaluate the longer term ..
  45. Development and Translational Assesment of a Tongue-Based Assistive Neuro-Technol
    Maysam Ghovanloo; Fiscal Year: 2010
    ..It can move rapidly and accurately within the mouth such that the tip can touch every single tooth...
  46. Tailored Touchscreen Colorectal Cancer Prevention in Urban Core Clinics
    K Allen Greiner; Fiscal Year: 2010
    ..This study will assess the efficacy of a novel tailored touch screen computer intervention based on an innovative integration of the Precaution Adoption Process Model (PAPM) ..
  47. Osteoarthritis Progression And Sensory Pathway Alterations
    Richard J Miller; Fiscal Year: 2013
    ..Specialized sensory neurons mediate different sensations, including touch, proprioception, vibration, and different types of noxious stimuli...
  48. Pneumatic Medicine: A transformative treatment for diabetic peripheral neuropathy
    LAURA F JACOBS; Fiscal Year: 2010
    ..respond to stimuli in the foot?") will be appraised with measureable non-invasive bedside testing: vibration, soft-touch cotton ball, sharp-touch jagged wooden sticks, and electro-diagnostic testing to measure nerve conduction...
  49. New Multiplexed Quantitative Detection of Pluripotency and Germ Layer Proteins
    Bradley H Garcia; Fiscal Year: 2011
    ..standardized analysis and reporting of data from assays run on the Spots on Dots" platform in a rapid, 'one touch'format...
  50. PDRemote: Automated Telehealth Diagnostics for Remote Parkinson's Monitoring
    JOSEPH GIUFFRIDA; Fiscal Year: 2013
    ..PD patients will be sent home with patient kit including an ergonomically designed touch-screen tablet PC, intuitive software interface for diaries, and a wireless motion sensor unit...
  51. Emotion &Intimate Partner Aggression: Processes &Outcomes in Parents &Children
    BRIAN ROBERT BAUCOM; Fiscal Year: 2012
    ..IPA and examines components of emotion using vocal fundamental frequency, facial expressions, and gaze, gesture, touch, and posture during 3-person conflict interactions between mothers, fathers and their adolescent child in 152 ..
  52. Rho GTPases and Neuroprotection Model in Cancer Therapy
    Qun Lu; Fiscal Year: 2012
    ..combinations enhance anti-cancer efficacy while reducing CIPN (measured by improving sural nerve conduction and touch sensation) in immunocompetent mice inoculated with syngeneic Lewis Lung carcinoma cells...
  53. Youth Mental Health Outcomes Tracking System: Self, Parent, & Clinician-Reported
    Benjamin B Brodey; Fiscal Year: 2010
    ..g., IVR, PCs, PDAs, touch-screens) for collecting patient-reported data and delivering reports to stakeholders...
  54. Evaluation of a Pulsed-Xenon Ultraviolet Room Disinfection Device
    John Zeber; Fiscal Year: 2013
    ..manual efforts focusing on visible soiled areas are usually insufficient and unreliable (70% of high-touch surfaces are missed)...
  55. GENETIC ANALYSIS OF NEMATODE CELL DIFFERENTIATION
    Martin Chalfie; Fiscal Year: 2013
    ..Most of the research will center, as in the past, on the analysis of the development and activity of the six touch receptor neurons (TRNs)...
  56. TRANSMISSION ELECTRON MICROSCOPE
    William S Talbot; Fiscal Year: 2010
    ..myelinated axons (Talbot);2) mechano-electrical transduction and microtubule cytoskeleton organization in nematode touch receptor neurons (Goodman);3) development of cell polarity in yeast (Pringle);4) the molecular basis of neuronal ..
  57. Virtual Advisors for Physical Activity Promotion in Underserved Communities
    Abby C King; Fiscal Year: 2013
    ..In a recently completed 4- month experiment, a computer-based bilingual Virtual Advisor with touch-screen interactivity (no keyboard or mouse needed) was housed in a community center and programmed to tailor PA ..
  58. Molecular and cellular mechanisms of Merkel Cell Carcinoma development
    Julien Sage; Fiscal Year: 2013
    ..growth of so-called Merkel cells, which serve as mechanoreceptors and osmoreceptors essential for light-touch response. MCC incidence is about 1,500 US cases per year, and this number is continually increasing...
  59. Neonatal Pain, Depression and Pain Susceptibility at Maturity in Rats
    Gayle Giboney Page; Fiscal Year: 2013
    ..and persistence of the resulting inflammation-induced hyperalgesic state with factors: female vs male;poke vs touch from postnatal day 1 - 8;chronic social defeat vs home cage control;and hind paw formalin vs saline...
  60. Physically Realistic Virtual Surgery
    DANIEL BOUGERE JONES; Fiscal Year: 2013
    ..is anticipated that computer generated virtual reality (VR)-based surgical simulators with both visual and haptic (touch) feedback will significantly improve minimally invasive surgical (MIS) training, leading to substantial reduction ..
  61. Sensorimotor loops in vibrissa somatosensation
    David Kleinfeld; Fiscal Year: 2013
    ..This may be used, based on our past work, to code touch in terms of coordinates that are normalized to the region of interest...
  62. The architecture and development of a sensory processing circuit for smell
    KRISTIN KAY BALDWIN; Fiscal Year: 2013
    ..In some sensory circuits, such as vision, hearing and touch, neurons with related response properties are organized in a stereotypic manner to form "maps" of sensory ..
  63. Neuroendocrine Mechanisms of Developmental Massage Therapy in Preterm Infants
    Laurie Moyer Mileur; Fiscal Year: 2009
    ..b>Touch'or massage therapy is associated with decreased cortisol levels and improved weight gain in premature infants...
  64. Non-Intrusive Automated Portable Data Collection System for Aging Surveys
    Cindy Crump; Fiscal Year: 2009
    ..3. A new paradigm for an elderly user interface via `surface computing'touch screens via a mobile, Apple iPhone to support easier mobile subject interaction anytime, anywhere in answering ..
  65. LCP Nerve Cuff with Telemetry for Prosthetic Sensation
    RONALD RISO; Fiscal Year: 2004
    ..Clinical applications include: 1) Stimulating the sensory nerves in the residual limbs of amputees to provide touch sensations from their prosthetic arms...
  66. 2009 Cellular Osmoregulation: Sensors, Transducers & Regulators GRC
    PAUL YANCEY; Fiscal Year: 2009
    ..As mechanotransduction is not only key to cellular osmostasis but also plays a crucial role in human hearing and touch, and involves sensing of forces such as osmotic pressure, membrane stretch, vibration, and touch, these areas are ..
  67. Cues from touch to aid posture and gait in individuals with Parkinson's disease
    Ely Rabin; Fiscal Year: 2010
    ..Haptic cues from touch hold great potential in this arena because studies in healthy subjects show haptic cues engage postural reflexes ..
  68. Exploiting the Power of GIS to Enhance Spatial Thinking in STEM Areas
    AMY LOBBEN; Fiscal Year: 2010
    ..A haptic (touch) soundscape (audio) minimal Geographic Information System (mGIS) will provide educators a first-ever pedagogic ..
  69. Spontaneous Arousals in "CHIME" Infants at Risk for SIDS
    ROBERT DARNALL; Fiscal Year: 2006
    ..be elicited by stimuli such as hypercapnia, hypoxia, laryngeal stimulation, changes in blood pressure, sound, or touch. It is clear that there are several 'levels' of arousal including subcortical (spinal and brainstem) and ..
  70. Awareness Enhancement and Monitoring Device for Treatment of Trichotillomania
    Joseph Himle; Fiscal Year: 2007
    ..to classify the nature of each hand to body touching incident as a hair pull, a near pull, or as an incidental touch. These incidents and their classification will be logged with a time and date stamp and downloaded to a personal ..
  71. Advancing Patient Call Light Systems to Achieve Better Outcomes
    Huey Ming Tzeng; Fiscal Year: 2010
    ..EloquenceTM is an advanced patient call light system that will use a touch screen for patients to deliver a specific message to nursing personnel, which will then be directed with an ..
  72. Reducing Adverse Self-Medication Behaviors in Older Adults with Hypertension
    Patricia Neafsey; Fiscal Year: 2007
    ..to include an interface to allow clients to enter self-medication behavior data independently on a wireless, touch screen tablet PC...
  73. Couples and Cancer: Building Partner Efficacy in Caring
    William Collinge; Fiscal Year: 2007
    ..Phase I focus groups identified common concerns about use of touch as support in cancer. We then delivered instruction using a workshop format...
  74. HIP FRACTURE RISK PREDICTION BY QDR
    Wilson Hayes; Fiscal Year: 2000
    ..impact site, and potential energy) exert a strong and potentially dominant influence on fracture risk and touch on a domain of risk independent of bone density...
  75. Technology to Improve Medication Safety in Nursing Homes
    Jill Scott Cawiezell; Fiscal Year: 2004
    ..The purpose of the study is to evaluate the use of bedside technology (One Touch eMAR System) and QIPMO (Quality Improvement Program for Missouri's Long-Term Care Facilities-QIPMO) to improve ..
  76. Dancing Dots Music Touch TTT: Multi-modal Teaching System for Blind musicians. T
    WILLIAM R MCCANN; Fiscal Year: 2010
    ..The TTT Music Touch Solution Add functionality to TTT to enable presentation of music concepts and literacy skills to blind readers...
  77. Efficacy of Healing Touch in Stressed Neonates
    Sharon McDonough Means; Fiscal Year: 2002
    ..Developmentally appropriate, nurturing stimulation is often lacking. Touch is critical in development of neonatal self-regulation...
  78. Functional Roles of Integrins in Modulating Neural Responses of Mechanically Sens
    Michael Hadjiargyrou; Fiscal Year: 2007
    ..by applicant): The long-term objectives of the investigators are to elucidate fundamental mechanisms whereby touch sensation is developed, how it is altered in the course of disease and injury, and to use that knowledge to ..
  79. Therapeutic IVR For Relapse Prevention in Chronic Pain
    Magdalena Naylor; Fiscal Year: 2009
    ..All four components can be accessed remotely by patients via any touch-tone phone. We initially tested the feasibility of the TIVR in a convenience pilot sample of 18 subjects...
  80. Mechanosensory Transduction Gordon Conference
    Paul Blount; Fiscal Year: 2007
    ..by applicant): The ability to detect mechanical forces is important in the human senses of balance, hearing, and touch as well as osmotic homeostasis and detection of blood pressure...