sound localization

Summary

Summary: Ability to determine the specific location of a sound source.

Top Publications

  1. ncbi Mechanisms of sound localization in mammals
    Benedikt Grothe
    Division of Neurobiology, Department of Biology II, Ludwig Maximilians Universitaet, Munich, Germany
    Physiol Rev 90:983-1012. 2010
  2. pmc A mechanistic understanding of the role of feedforward inhibition in the mammalian sound localization circuitry
    Michael T Roberts
    Section of Neurobiology and Center for Learning and Memory, University of Texas at Austin, Austin, TX 78712, USA
    Neuron 78:923-35. 2013
  3. pmc Spatial and temporal processing of single auditory cortical neurons and populations of neurons in the macaque monkey
    Gregg H Recanzone
    Center for Neuroscience, Department of Neurobiology, Physiology and Behavior, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA
    Hear Res 271:115-22. 2011
  4. ncbi Interaural time difference processing in the mammalian medial superior olive: the role of glycinergic inhibition
    Michael Pecka
    Division of Neurobiology, Department Biology II, Ludwig Maximilians University Munich, D 82152 Martinsried, Germany
    J Neurosci 28:6914-25. 2008
  5. pmc Multiplexed and robust representations of sound features in auditory cortex
    Kerry M M Walker
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK
    J Neurosci 31:14565-76. 2011
  6. ncbi A neural code for low-frequency sound localization in mammals
    D McAlpine
    MRC Institute of Hearing Research, Science Road, University of Nottingham, Nottingham NG7 2RD, UK
    Nat Neurosci 4:396-401. 2001
  7. pmc Two GABAA responses with distinct kinetics in a sound localization circuit
    Zheng Quan Tang
    Department of Anatomy and Neurobiology, College of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA
    J Physiol 590:3787-805. 2012
  8. ncbi Listener weighting of cues for lateral angle: the duplex theory of sound localization revisited
    Ewan A Macpherson
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor 48109 0506, USA
    J Acoust Soc Am 111:2219-36. 2002
  9. ncbi Retrograde GABA signaling adjusts sound localization by balancing excitation and inhibition in the brainstem
    Anna K Magnusson
    Department Biologie II, Division of Neurobiology, LMU Munich, Grosshadernerstrasse 2, 82152 Martinsried, Germany
    Neuron 59:125-37. 2008
  10. ncbi Perception of sound-source motion by the human brain
    Jason D Warren
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Neuron 34:139-48. 2002

Detail Information

Publications291 found, 100 shown here

  1. ncbi Mechanisms of sound localization in mammals
    Benedikt Grothe
    Division of Neurobiology, Department of Biology II, Ludwig Maximilians Universitaet, Munich, Germany
    Physiol Rev 90:983-1012. 2010
    ..elaborate on recent advances in the understanding of mammalian subcortical processing of auditory spatial cues that challenge the "textbook" version of sound localization, in particular brain mechanisms contributing to binaural hearing.
  2. pmc A mechanistic understanding of the role of feedforward inhibition in the mammalian sound localization circuitry
    Michael T Roberts
    Section of Neurobiology and Center for Learning and Memory, University of Texas at Austin, Austin, TX 78712, USA
    Neuron 78:923-35. 2013
    ..The interplay between inhibition and potassium conductances thus improves the consistency and resolution of ITD coding across different frequencies...
  3. pmc Spatial and temporal processing of single auditory cortical neurons and populations of neurons in the macaque monkey
    Gregg H Recanzone
    Center for Neuroscience, Department of Neurobiology, Physiology and Behavior, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA
    Hear Res 271:115-22. 2011
    ..Together these studies indicate that the alert macaque monkey is an excellent model system to study both spatial and temporal processing in the auditory cortex at the single neuron level...
  4. ncbi Interaural time difference processing in the mammalian medial superior olive: the role of glycinergic inhibition
    Michael Pecka
    Division of Neurobiology, Department Biology II, Ludwig Maximilians University Munich, D 82152 Martinsried, Germany
    J Neurosci 28:6914-25. 2008
    ..Hence tonic glycine application experimentally decoupled the effect of inhibition from the timing of its inputs. We conclude that, for proper ITD processing, not only is inhibition necessary, but it must also be precisely timed...
  5. pmc Multiplexed and robust representations of sound features in auditory cortex
    Kerry M M Walker
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK
    J Neurosci 31:14565-76. 2011
    ..Finally, we observed that formant information is encoded in cortex earlier than pitch information, and we show that this time course matches ferrets' behavioral reaction time differences on a change detection task...
  6. ncbi A neural code for low-frequency sound localization in mammals
    D McAlpine
    MRC Institute of Hearing Research, Science Road, University of Nottingham, Nottingham NG7 2RD, UK
    Nat Neurosci 4:396-401. 2001
    ..These data provide support for a processing of the output of coincidence detectors subserving low-frequency sound localization in which the location of a sound source is determined by the activity in two broad, hemispheric spatial ..
  7. pmc Two GABAA responses with distinct kinetics in a sound localization circuit
    Zheng Quan Tang
    Department of Anatomy and Neurobiology, College of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA
    J Physiol 590:3787-805. 2012
    ..in neurons of the chicken nucleus laminaris (NL), the first encoder of interaural time difference for sound localization in birds...
  8. ncbi Listener weighting of cues for lateral angle: the duplex theory of sound localization revisited
    Ewan A Macpherson
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor 48109 0506, USA
    J Acoust Soc Am 111:2219-36. 2002
    ..For wideband stimuli, the ITD weight was greater than or equal to that given to ILD. Manipulations of monaural spectral cues and the interaural level spectrum had little influence on lateral angle judgements...
  9. ncbi Retrograde GABA signaling adjusts sound localization by balancing excitation and inhibition in the brainstem
    Anna K Magnusson
    Department Biologie II, Division of Neurobiology, LMU Munich, Grosshadernerstrasse 2, 82152 Martinsried, Germany
    Neuron 59:125-37. 2008
    ....
  10. ncbi Perception of sound-source motion by the human brain
    Jason D Warren
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Neuron 34:139-48. 2002
    ..The results support the existence of a posteriorly directed temporo-parietal pathway for obligatory perceptual processing of sound-source motion...
  11. pmc Auditory cortex spatial sensitivity sharpens during task performance
    Chen Chung Lee
    Kresge Hearing Research Institute, Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Nat Neurosci 14:108-14. 2011
    Activity in the primary auditory cortex (A1) is essential for normal sound localization behavior, but previous studies of the spatial sensitivity of neurons in A1 have found broad spatial tuning...
  12. pmc A physiologically based model of interaural time difference discrimination
    Kenneth E Hancock
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Neurosci 24:7110-7. 2004
    ..The physiological data confirms evidence from the guinea pig that BD varies systematically with BF, generalizing the observation across species...
  13. pmc Task-modulated "what" and "where" pathways in human auditory cortex
    Jyrki Ahveninen
    Harvard Medical School Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, CNY 149 13th Street, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 103:14608-13. 2006
    ..human nonprimary auditory cortex, as suggested by animal models, and whether selective attention facilitates sound localization and identification by modulating these pathways in a feature-specific fashion...
  14. pmc The descending corticocollicular pathway mediates learning-induced auditory plasticity
    Victoria M Bajo
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Nat Neurosci 13:253-60. 2010
    ..We examined the role of these neurons in experience-dependent recalibration of sound localization in adult ferrets by selectively killing the neurons using chromophore-targeted laser photolysis...
  15. ncbi The Speech, Spatial and Qualities of Hearing Scale (SSQ)
    Stuart Gatehouse
    MRC Institute of Hearing Research, Glasgow, UK
    Int J Audiol 43:85-99. 2004
    ..The SSQ shows promise as an instrument for evaluating interventions of various kinds, particularly (but not exclusively) those that implicate binaural function...
  16. pmc Neural circuits underlying adaptation and learning in the perception of auditory space
    Andrew J King
    Department of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford, UK
    Neurosci Biobehav Rev 35:2129-39. 2011
    b>Sound localization mechanisms are particularly plastic during development, when the monaural and binaural acoustic cues that form the basis for spatial hearing change in value as the body grows...
  17. ncbi Improved auditory spatial acuity in visually deprived ferrets
    A J King
    University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, UK
    Eur J Neurosci 11:3945-56. 1999
    ..This is consistent with reports that congenitally blind humans can localize peripheral sounds more accurately than normal controls...
  18. ncbi A matter of time: internal delays in binaural processing
    Philip Joris
    Laboratory of Auditory Neurophysiology, University of Leuven, Campus Gasthuisberg, O and N2 Herestraat 49, Bus 1021, B 3000 Leuven, Belgium
    Trends Neurosci 30:70-8. 2007
    ..We review the alternatives, and argue that an understanding of binaural mechanisms requires consideration of sensitivity not only to ITDs, but also to interaural correlation...
  19. ncbi Distinct pathways involved in sound recognition and localization: a human fMRI study
    P P Maeder
    Service de radiodiagnostic et radiologie interventionnelle, CHUV, Lausanne, Switzerland
    Neuroimage 14:802-16. 2001
    ..Passive listening paradigm revealed segregated pathways on superior temporal gyrus and inferior parietal lobule. Thus, anatomically distinct networks are involved in sound recognition and sound localization.
  20. pmc Location coding by opponent neural populations in the auditory cortex
    G Christopher Stecker
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan, USA
    PLoS Biol 3:e78. 2005
    Although the auditory cortex plays a necessary role in sound localization, physiological investigations in the cortex reveal inhomogeneous sampling of auditory space that is difficult to reconcile with localization behavior under the ..
  21. ncbi Relations between frequency selectivity, temporal fine-structure processing, and speech reception in impaired hearing
    Olaf Strelcyk
    Centre for Applied Hearing Research, Department of Electrical Engineering, Technical University of Denmark, Building 352, Orsteds Plads, 2800 Kgs Lyngby, Denmark
    J Acoust Soc Am 125:3328-45. 2009
    ..The results provide constraints for future models of impaired auditory signal processing...
  22. pmc A rate code for sound azimuth in monkey auditory cortex: implications for human neuroimaging studies
    Uri Werner-Reiss
    Department of Psychology and Neuroscience, Center for Cognitive Neuroscience, Duke University, Durham, North Carolina 27708, USA
    J Neurosci 28:3747-58. 2008
    ....
  23. ncbi Adaptation in sound localization: from GABA(B) receptor-mediated synaptic modulation to perception
    Annette Stange
    Division of Neurobiology, Department Biologie II, Ludwig Maximilians Universitat Munchen, Planegg Martinsried, Germany
    Nat Neurosci 16:1840-7. 2013
    ..it has long been assumed that the processing of interaural time differences, which is the primary cue for sound localization, is nonadaptive, as its outputs are mapped directly onto a hard-wired representation of space...
  24. pmc A population rate code of auditory space in the human cortex
    Nelli H Salminen
    Department of Biomedical Engineering and Computational Science, Helsinki University of Technology, Helsinki, Finland
    PLoS ONE 4:e7600. 2009
    ..Previous work on the human auditory cortex has revealed areas specialized in spatial processing but how the neurons in these areas represent the location of a sound source remains unknown...
  25. ncbi The coding of spatial location by single units in the lateral superior olive of the cat. I. Spatial receptive fields in azimuth
    Daniel J Tollin
    Department of Physiology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Neurosci 22:1454-67. 2002
    ..Sensitivity to spatial location was also retained over a wide range of stimulus levels under binaural, but not monaural, conditions...
  26. ncbi Spectral information in sound localization
    Simon Carlile
    Auditory Neuroscience Laboratory, School of Medical Sciences University of Sydney, Sydney NSW 2006, Australia
    Int Rev Neurobiol 70:399-434. 2005
  27. ncbi Time-course of posterior parietal and occipital cortex contribution to sound localization
    Olivier Collignon
    Neural Rehabilitation Engineering Laboratory, Universite Catholique de Louvain, Brussels, Belgium
    J Cogn Neurosci 20:1454-63. 2008
    ..The finding that the right OC is involved in sound processing before the right PPC suggests that the OC exerts a feedforward influence on the PPC during auditory spatial processing...
  28. ncbi Auditory and visual objects
    M Kubovy
    Department of Psychology, University of Virginia, Charlottesville, VA 22904 4400, USA
    Cognition 80:97-126. 2001
    ..Finally, we present evidence for - and elaborate on - the hypothesis that the auditory 'where' subsystem is in the service of the visual-motor 'where' subsystem...
  29. pmc Interdependent encoding of pitch, timbre, and spatial location in auditory cortex
    Jennifer K Bizley
    Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom
    J Neurosci 29:2064-75. 2009
    ..Such nonlinearities were most prevalent in primary auditory cortex, although they tended to be small compared with stimulus main effects...
  30. ncbi Effect of behavioral context on representation of a spatial cue in core auditory cortex of awake macaques
    Brian H Scott
    Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 27:6489-99. 2007
    ..Macaques were trained to discriminate binaural cues to sound localization, eventually allowing measurement of thresholds comparable to human hearing...
  31. pmc Visual Motion Area MT+/V5 Responds to Auditory Motion in Human Sight-Recovery Subjects
    Melissa Saenz
    Computation and Neural Systems, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 28:5141-8. 2008
    ..Regarding sight recovery after early blindness, our results further demonstrate that cross-modal responses coexist with regained visual responses within the visual cortex...
  32. ncbi Auditory capture of vision: examining temporal ventriloquism
    Sharon Morein-Zamir
    Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC V6T 1Z4, Canada
    Brain Res Cogn Brain Res 17:154-63. 2003
    ..The results suggest a 'temporal ventriloquism' phenomenon analogous to spatial ventriloquism...
  33. ncbi Coding of auditory space
    Masakazu Konishi
    Division of Biology 216 76, California Institute of Technology, Pasadena, CA 91125, USA
    Annu Rev Neurosci 26:31-55. 2003
    Behavioral, anatomical, and physiological approaches can be integrated in the study of sound localization in barn owls. Space representation in owls provides a useful example for discussion of place and ensemble coding...
  34. ncbi Modeling individual differences in ferret external ear transfer functions
    Jan W H Schnupp
    University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, United Kingdom
    J Acoust Soc Am 113:2021-30. 2003
    ....
  35. pmc Adaptive reweighting of auditory localization cues in response to chronic unilateral earplugging in humans
    Daniel P Kumpik
    Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom
    J Neurosci 30:4883-94. 2010
    ..Previous studies indicate that the brain circuits underlying sound localization are calibrated by experience of the cues available to each individual...
  36. pmc Functional specialization of medial auditory belt cortex in the alert rhesus monkey
    Pawel Kusmierek
    Department of Physiology and Biophysics, Georgetown University, NRB WP23, 3970 Reservoir Rd NW, Washington, DC, USA
    J Neurophysiol 102:1606-22. 2009
    ..The anteroposterior difference in temporal processing indices suggests that R and RM may belong to a different hierarchical level or a different computational network than A1 and MM...
  37. ncbi Neural population coding of sound level adapts to stimulus statistics
    Isabel Dean
    Department of Physiology and University College London Ear Institute, UK
    Nat Neurosci 8:1684-9. 2005
    ..This extends the range of sound levels that can be accurately encoded, fine-tuning hearing to the local acoustic environment...
  38. ncbi The precedence effect
    R Y Litovsky
    Hearing Research Center, Boston University, Massachusetts 02215, USA
    J Acoust Soc Am 106:1633-54. 1999
    ..It is probably only through the combined efforts of these fields that a full theory of precedence will evolve and useful models will be developed...
  39. ncbi Is there a role of visual cortex in spatial hearing?
    Ulrike Zimmer
    Section Neuropsychology, Department of Cognitive Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Eur J Neurosci 20:3148-56. 2004
    ..This result suggests a relation of neural processing in the visual cortex and the transformation of auditory spatial coordinates responsible for maintaining the perceptual alignment of audition and vision with changes in gaze direction...
  40. ncbi Spectro-temporal factors in two-dimensional human sound localization
    P M Hofman
    University of Nijmegen, Department of Medical Physics and Biophysics, The Netherlands
    J Acoust Soc Am 103:2634-48. 1998
    This paper describes the effect of spectro-temporal factors on human sound localization performance in two dimensions (2D). Subjects responded with saccadic eye movements to acoustic stimuli presented in the frontal hemisphere...
  41. pmc Can measures of sound localization acuity be related to the precision of absolute location estimates?
    Jordan M Moore
    Department of Physiology, University of Wisconsin Madison, Madison, WI 53706, USA
    Hear Res 238:94-109. 2008
    Studies of sound localization use relative or absolute psychoacoustic paradigms...
  42. ncbi Mechanisms underlying phonotactic steering in the cricket Gryllus bimaculatus revealed with a fast trackball system
    B Hedwig
    University of Cambridge, Department of Zoology, Downing Street, Cambridge CB2 3EJ, UK
    J Exp Biol 208:915-27. 2005
    ..Rather, these experiments suggest that fast steering to single sound pulses determines the lateral deviation of the animals and that complex auditory orientation emerges from this simple mechanism of auditory steering...
  43. ncbi A common cortical substrate activated by horizontal and vertical sound movement in the human brain
    Francesco Pavani
    Institute of Cognitive Neuroscience, University College London, London, United Kingdom
    Curr Biol 12:1584-90. 2002
    ..These results demonstrate that sound movement in vertical and horizontal dimensions engages a common processing network in the human cerebral cortex and show that multidimensional spatial properties of sounds are processed at this level...
  44. ncbi Stability of central binaural sound localization mechanisms in mammals, and the Heffner hypothesis
    Dennis P Phillips
    Department of Psychology, Dalhousie University, Halifax, 1355 Oxford Street, Nova Scotia, Canada
    Neurosci Biobehav Rev 36:889-900. 2012
    Heffner (2004) provided an overview of data on the evolutionary pressures on sound localization acuity in mammals...
  45. ncbi New roles for synaptic inhibition in sound localization
    Benedikt Grothe
    Max Planck Institute of Neurobiology, Auditory Processing Group, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    Nat Rev Neurosci 4:540-50. 2003
  46. pmc Adaptation of sound localization induced by rotated visual feedback in reaching movements
    Florian A Kagerer
    Cognitive Motor Neuroscience Laboratory, Department of Kinesiology and Graduate Program in Neuroscience and Cognitive Science, University of Maryland School of Public Health, College Park, MD 20742, USA
    Exp Brain Res 193:315-21. 2009
    ..This plasticity in human sound localization does not require active cross-modal experience, and retention tests indicated that the newly formed internal ..
  47. ncbi Early- and late-onset blind individuals show supra-normal auditory abilities in far-space
    Patrice Voss
    Centre de Recherche en Neuropsychologie et Cognition, Universite de Montreal, Case Postale 6128, Succursale Centre Ville, Montreal, Quebec, H3C 3J7, Canada
    Curr Biol 14:1734-8. 2004
    ..Nonetheless, we show for the first time that even late-onset blind subjects develop above-normal spatial abilities, suggesting that significant compensation can occur in the adult...
  48. pmc Matched filters, mate choice and the evolution of sexually selected traits
    Konstantinos Kostarakos
    Zoology, Karl Franzens University, Graz, Austria
    PLoS ONE 3:e3005. 2008
    ..However, individual differences in female preference functions and their proximate causation have rarely been studied...
  49. ncbi The medial nucleus of the trapezoid body in rat: spectral and temporal properties vary with anatomical location of the units
    Sandra Tolnai
    Department of Cell Biology and Pathology, Faculty of Medicine, University of Salamanca, Salamanca, Spain
    Eur J Neurosci 27:2587-98. 2008
    ....
  50. ncbi Limited segregation of different types of sound localization information among classes of units in the inferior colliculus
    Steven M Chase
    Center for Hearing Sciences, Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Neurosci 25:7575-85. 2005
    ..These results are the first to quantify the relative representation of cues in terms of information and suggest a variety of degrees of cue integration in the ICC...
  51. ncbi Human cortical auditory motion areas are not motion selective
    Kevin R Smith
    Department of Cognitive Sciences, University of California, Irvine, CA 92612, USA
    Neuroreport 15:1523-6. 2004
    ..However, stationary stimuli presented at varying locations activated these regions equally well, arguing against the existence of specialized motion-processing areas in human cortex...
  52. ncbi Distributed coding of sound locations in the auditory cortex
    G Christopher Stecker
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI 48109 0506, USA
    Biol Cybern 89:341-9. 2003
    Although the auditory cortex plays an important role in sound localization, that role is not well understood. In this paper, we examine the nature of spatial representation within the auditory cortex, focusing on three questions...
  53. ncbi The influence of spectral, temporal, and interaural stimulus variations on the precedence effect
    Roberto M Dizon
    Hearing Research Center, Boston University, 44 Cummington Street, Boston, Massachusetts 02215, USA
    J Acoust Soc Am 119:2947-64. 2006
    ....
  54. ncbi A two-choice sound localization procedure for detecting lateralized tinnitus in animals
    Henry E Heffner
    Department of Psychology, University of Toledo, 2801 West Bancroft, Toledo, OH 43606, USA
    Behav Res Methods 43:577-89. 2011
    ..Exposing rats to loud tones of various frequencies indicated that frequencies near the limits of the rat's hearing range were less likely to cause tinnitus than tones in the midrange...
  55. pmc Binaural sensitivity changes between cortical on and off responses
    Douglas E H Hartley
    Department of Physiology, Anatomy, and Genetics, Oxford University, Oxford, United Kingdom
    J Neurophysiol 106:30-43. 2011
    ..Rather than reflecting a release from inhibition without any functional significance, we propose that binaural off responses may be important to cortical encoding of sound-source location...
  56. pmc Inhibition in the balance: binaurally coupled inhibitory feedback in sound localization circuitry
    R Michael Burger
    Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA
    J Neurophysiol 106:4-14. 2011
    ..Our recent studies in the chicken have made significant progress in bringing together many of these findings to provide a cohesive picture of inhibitory function...
  57. pmc Tonotopic tuning in a sound localization circuit
    Sean J Slee
    Department of Physiology and Biophysics, University of Washington, Seattle, Washington, USA
    J Neurophysiol 103:2857-75. 2010
    ..Models constructed from the experimental data for each tonotopic region demonstrate that the tonotopic tuning measured in NL can improve ITD encoding across sound frequencies...
  58. pmc A dominance hierarchy of auditory spatial cues in barn owls
    Ilana B Witten
    Neurobiology Department, Stanford University Medical Center, Stanford, California, United States of America
    PLoS ONE 5:e10396. 2010
    ..Barn owls integrate spatial information across frequency channels to localize sounds in space...
  59. ncbi A novel type of auditory responses: temporal dynamics of 40-Hz steady-state responses induced by changes in sound localization
    Bernhard Ross
    Rotman Research Institute, Baycrest Centre, University of Toronto, Toronto, Ontario, Canada
    J Neurophysiol 100:1265-77. 2008
    ..Responses to changes from focal to spacious sound were larger than those in the reverse direction. The ASSRs were interpreted in relation to oscillatory gamma-band activity representing auditory object representation...
  60. pmc Bilateral cochlear implantation in the ferret: a novel animal model for behavioral studies
    Douglas E H Hartley
    Department of Physiology, Anatomy and Genetics, Oxford OX1 3PT, UK
    J Neurosci Methods 190:214-28. 2010
    ..has recently been introduced with the aim of improving both speech perception in background noise and sound localization. Although evidence suggests that binaural perception is possible with two cochlear implants, results in ..
  61. pmc Specialization of binaural responses in ventral auditory cortices
    Nathan C Higgins
    Department of Psychology, Behavioral Neuroscience Division, University of Connecticut, Storrs, Connecticut 06269, USA
    J Neurosci 30:14522-32. 2010
    ..SRAF had the highest incidence of binaural facilitation for ILD cues corresponding to midline positions, supporting current theories that auditory cortices have specialized and hierarchical functional organization...
  62. ncbi Auditory spatial receptive fields created by multiplication
    J L Pena
    Division of Biology 216 76, California Institute of Technology, Pasadena, CA 91125, USA
    Science 292:249-52. 2001
    ..Other nonlinear processes improve the spatial tuning of the spike output and reduce the fit to the multiplicative model...
  63. ncbi The role of the right parietal cortex in sound localization: a chronometric single pulse transcranial magnetic stimulation study
    Ayse At
    Service de Neuropsychologie et de Neuroréhabilitation, Departement des neurosciences cliniques, CHUV, Universtité de Lausanne, Switzerland
    Neuropsychologia 49:2794-7. 2011
    ....
  64. ncbi Comparison of relative and absolute sound localization ability in humans
    G H Recanzone
    Center for Neuroscience, University of California at Davis 95616, USA
    J Acoust Soc Am 103:1085-97. 1998
    b>Sound localization ability has traditionally been studied using either a relative localization task, where thresholds to determine a difference in sound source location is approximately 1-10 degrees, or an absolute localization task, ..
  65. ncbi Passive sound localization of prey by the pallid bat (Antrozous p. pallidus)
    Z M Fuzessery
    Department of Zoology Physiology, University of Wyoming, Laramie 82071
    J Comp Physiol A 171:767-77. 1993
    The pallid bat (Antrozous p. pallidus) uses passive sound localization to capture terrestrial prey...
  66. pmc Sound localization ability and glycinergic innervation of the superior olivary complex persist after genetic deletion of the medial nucleus of the trapezoid body
    Walid Jalabi
    Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio 44106, Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, LE1 9HN, United Kingdom, Department of Neurobiology and Anatomy, University of Rochester, Rochester, New York 14642, and Richard King Mellon Institute for Pediatric Research, Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania 15224
    J Neurosci 33:15044-9. 2013
    ..body (MNTB) in the superior olivary complex (SOC) is an inhibitory hub considered critical for binaural sound localization. We show that genetic ablation of MNTB neurons in mice only subtly affects this ability by prolonging the ..
  67. pmc Specialization for sound localization in fields A1, DZ, and PAF of cat auditory cortex
    Chen Chung Lee
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI 48109, USA
    J Assoc Res Otolaryngol 14:61-82. 2013
    ..implicated the primary auditory cortex (A1), the dorsal zone (DZ), and the posterior auditory field (PAF) in sound localization behavior, and physiological studies in anesthetized conditions have demonstrated clear differences in ..
  68. ncbi A neuronal population code for sound localization
    D C Fitzpatrick
    Department of Anatomy, University of Connecticut Health Center, Farmington 06030 3405, USA
    Nature 388:871-4. 1997
    ..We also show that this sharper tuning increases the efficiency of the population code, in the sense that fewer neurons are required to achieve a given acuity...
  69. ncbi Bayesian reconstruction of sound localization cues from responses to random spectra
    Paul M Hofman
    Department of Biophysics, University of Nijmegen, Geert Grooteplein 21, 6525 EZ Nijmegen, The Netherlands
    Biol Cybern 86:305-16. 2002
    ..However, it is still unclear which of the pinna-induced features play a role in sound localization. The present study presents a method for the reconstruction of the spatially relevant features in the ..
  70. ncbi Exceptional ability of blind humans to hear sound motion: implications for the emergence of auditory space
    Jörg Lewald
    Department of Cognitive Psychology, Faculty of Psychology, Ruhr University Bochum, D 44780 Bochum, Germany
    Neuropsychologia 51:181-6. 2013
    ....
  71. ncbi Seeing with sound? exploring different characteristics of a visual-to-auditory sensory substitution device
    David Brown
    School of Psychology, University of Sussex, Falmer, Brighton BN1 9QH, UK
    Perception 40:1120-35. 2011
    ..In general, the results suggest that the auditory characteristics of the device may be more important for initial learning than visual associations...
  72. ncbi Enhancement of visual perception by crossmodal visuo-auditory interaction
    Francesca Frassinetti
    Dipartimento di Psicologia, Universita degli Studi di Bologna, Italy
    Exp Brain Res 147:332-43. 2002
    ..An enhancement of the perceptual sensitivity (d') for luminance detection was found when the audiovisual stimuli followed a rather clear spatial and temporal rule, governing multisensory integration at the neuronal level...
  73. ncbi Effects of spatial separation and stimulus probability on the event-related potentials elicited by occasional changes in sound location
    Ranil R Sonnadara
    Department of Psychology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    Brain Res 1071:175-85. 2006
    ..The early latency of MMN for changes in sound location is interpreted in the context of an early-warning system to alert the organism to new sound sources in the environment...
  74. ncbi Role of auditory cortex in sound localization in the midsagittal plane
    Jennifer K Bizley
    Department of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford OX1 3PT, UK
    J Neurophysiol 98:1763-74. 2007
    Although the auditory cortex is known to be essential for normal sound localization in the horizontal plane, its contribution to vertical localization has not so far been examined...
  75. pmc Monaural deprivation disrupts development of binaural selectivity in auditory midbrain and cortex
    Maria V Popescu
    Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Neuron 65:718-31. 2010
    ....
  76. ncbi Localization cues with bilateral cochlear implants
    Bernhard U Seeber
    Institute for Human Machine Communication, Technische Universität München Arcisstr 21, 80333 München, Germany
    J Acoust Soc Am 123:1030-42. 2008
    ..Localization shifted predominantly for offsets in ILDs, even for pulsed high-pass noise. This confirms that envelope ITDs contributed little and that localization with bilateral CIs was dominated by ILDs...
  77. ncbi Cues for sound localization are encoded in multiple aspects of spike trains in the inferior colliculus
    Steven M Chase
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA
    J Neurophysiol 99:1672-82. 2008
    ..The differential coding of the localization cues suggests that information about multiple cues could be multiplexed onto the responses of single neurons...
  78. ncbi Role of the dorsal cochlear nucleus in the sound localization behavior of cats
    B J May
    Department of Otolaryngology HNS, The Johns Hopkins University, 505 Traylor Research Bldg, 720 Rutland Avenue, Baltimore, MD 21205 2195, USA
    Hear Res 148:74-87. 2000
    The role of the dorsal cochlear nucleus (DCN) in directional hearing was evaluated by measuring sound localization behaviors before and after cats received lesions of the dorsal and intermediate acoustic striae (DAS/IAS)...
  79. ncbi Vestibular influence on human auditory space perception
    J Lewald
    Institute for Occupational Physiology at the University of Dortmund, D 44139 Dortmund, Germany
    J Neurophysiol 84:1107-11. 2000
    ..We thus hypothesize that vestibular information is used by central-nervous mechanisms generating a world-centered representation of auditory space...
  80. pmc Influence of task-relevant and task-irrelevant feature continuity on selective auditory attention
    Ross K Maddox
    Hearing Research Center, Biomedical Engineering, Boston, MA 02215, USA
    J Assoc Res Otolaryngol 13:119-29. 2012
    ....
  81. ncbi Exploring the benefits of bilateral cochlear implants
    Richard J M van Hoesel
    CRC for Cochlear Implant and Hearing Aid Innovation, Melbourne, Victoria, Australia
    Audiol Neurootol 9:234-46. 2004
    ..Data from a number of new studies are presented to discuss these and other issues related to the potential to benefit from bilateral implantation...
  82. ncbi EEG coherence in early-blind humans during sound localization
    Charles Leclerc
    Centre de Recherche en Neuropsychologie et Cognition, Departement de Psychologie, Universite de Montreal, Que, H3C 3J7, Canada
    Neurosci Lett 376:154-9. 2005
    ..A further ERP study with these subjects also revealed N1 and P3 components during a sound localization task to be more posteriorly distributed than for sighted controls, indicating an involvement of posterior ..
  83. pmc Olivocochlear efferent control in sound localization and experience-dependent learning
    Samuel Irving
    Medical Research Council Institute of Hearing Research, Nottingham NG7 2RD, United Kingdom
    J Neurosci 31:2493-501. 2011
    Efferent auditory pathways have been implicated in sound localization and its plasticity...
  84. ncbi Distortions of auditory space during rapid head turns
    Joel Cooper
    Auditory Neuroscience Laboratory, School of Medical Science and Bosch Institute, University of Sydney, Sydney, NSW 2006, Australia
    Exp Brain Res 191:209-19. 2008
    ..The results are interpreted in terms of a 'multiple look' strategy for calculating sound location, and the allocation of attention to the hemisphere containing the head-turn target...
  85. ncbi Spatial sensitivity in field PAF of cat auditory cortex
    G Christopher Stecker
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan 48109 0506, USA
    J Neurophysiol 89:2889-903. 2003
    ..The latter finding suggests more accurate population coding of space in PAF, made possible by a more diverse population of neural response types...
  86. pmc Accurate sound localization in reverberant environments is mediated by robust encoding of spatial cues in the auditory midbrain
    Sasha Devore
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Neuron 62:123-34. 2009
    ..reflections interfere with the direct sound arriving at a listener's ears, distorting the spatial cues for sound localization. Yet, human listeners have little difficulty localizing sounds in most settings...
  87. ncbi Occasional changes in sound location enhance middle latency evoked responses
    Ranil R Sonnadara
    Department of Psychology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1
    Brain Res 1076:187-92. 2006
    ..Our data suggest that any such processing is in fact preceded by activation in primary auditory cortex...
  88. ncbi Early phase of spatial mismatch negativity is localized to a posterior "where" auditory pathway
    Matthew S Tata
    Department of Psychology and Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB T1 K 3M4, Canada
    Exp Brain Res 167:481-6. 2005
    ..The posterior location of the early-phase generator suggests the engagement of neurons within a putative "where" pathway for processing spatial auditory information...
  89. pmc Contralateral effects and binaural interactions in dorsal cochlear nucleus
    Kevin A Davis
    Departments of Biomedical Engineering and Neurobiology and Anatomy and the Center for Navigation and Communication Sciences, University of Rochester, Rochester, NY 14642, USA
    J Assoc Res Otolaryngol 6:280-96. 2005
    ..results show that the contralateral inputs to the DCN are functionally relevant in natural listening conditions, and that one role of these inputs is to enhance DCN processing of spectral sound localization cues produced by the pinna.
  90. ncbi Spatial and non-spatial auditory processing in the lateral intraparietal area
    Gordon W Gifford
    Department of Psychological and Brain Science, Dartmouth College, 6207 Moore, Hanover, NH 03755, USA
    Exp Brain Res 162:509-12. 2005
    ..We found that the firing rates of LIP neurons were modulated by both of these attributes. These data indicate that, while area LIP is involved in spatial processing, non-spatial processing is not restricted to independent channels...
  91. ncbi Processing of sound location in human cortex
    Jörg Lewald
    Leibniz Research Centre for Working Environment and Human Factors, Institute for Occupational Physiology at University of Dortmund, Ardeystr 67, D 44139 Dortmund, Germany
    Eur J Neurosci 27:1261-70. 2008
    ..On the other hand, this result may suggest the existence of shared neural networks, performing analyses of auditory 'higher-order' cues for both localization and identification of sound sources...
  92. ncbi The intraparietal sulcus and perceptual organization
    Rhodri Cusack
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    J Cogn Neurosci 17:641-51. 2005
    ..This evidence is discussed, and a general role proposed for regions of the IPS in structuring sensory input...
  93. pmc Detection of interaural time differences in the alligator
    Catherine E Carr
    Department of Biology, University of Maryland, College Park, Maryland 20742 4415, USA
    J Neurosci 29:7978-90. 2009
    ..Thus, crocodilians and birds employ similar algorithms for ITD detection, although crocodilians have larger heads...
  94. ncbi Sound localization under perturbed binaural hearing
    Marc M Van Wanrooij
    Department of Biophysics, Radboud University Nijmegen, Geert Grooteplein 21, 6525 EZ Nijmegen, The Netherlands
    J Neurophysiol 97:715-26. 2007
    ..b>Sound localization behavior was tested with rapid head-orienting responses toward brief high-pass filtered (>3 kHz; HP) and ..
  95. pmc Discrimination and identification of azimuth using spectral shape
    DANIEL E SHUB
    Speech and Hearing Bioscience and Technology Program, Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Acoust Soc Am 124:3132-41. 2008
    ..The best monaural MAAs were less than 5 degrees. The MAAs were consistent with a theoretical analysis of the HRTFs, which suggests that monaural azimuthal discrimination is related to spectral-shape discrimination...
  96. ncbi Processing of location and pattern changes of natural sounds in the human auditory cortex
    Christian F Altmann
    Institute of Medical Psychology, Johann Wolfgang Goethe University, Heinrich Hoffmann Strasse 10, 60528, Frankfurt am Main, Germany
    Neuroimage 35:1192-200. 2007
    ....
  97. ncbi Effects of interaural decorrelation on neural and behavioral detection of spatial cues
    K Saberi
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Neuron 21:789-98. 1998
    The detection of interaural time differences (ITDs) for sound localization critically depends on the similarity between the left and right ear signals (interaural correlation)...
  98. pmc Cross-correlation in the auditory coincidence detectors of owls
    Brian J Fischer
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 28:8107-15. 2008
    Interaural time difference (ITD) plays a central role in many auditory functions, most importantly in sound localization. The classic model for how ITD is computed was put forth by Jeffress (1948)...
  99. ncbi Functional specialization in rhesus monkey auditory cortex
    B Tian
    Georgetown Institute for Cognitive and Computational Sciences, Department of Physiology and Biophysics, Georgetown University Medical Center, Washington, DC 20007, USA
    Science 292:290-3. 2001
    ..These results suggest that cortical processing of auditory spatial and pattern information is performed in specialized streams rather than one homogeneously distributed system...
  100. pmc Auditory looming perception in rhesus monkeys
    Asif A Ghazanfar
    Max Planck Institute for Biological Cybernetics, Spemanstrasse 38, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 99:15755-7. 2002
    ..These response biases to looming sounds are consistent with an evolved neural mechanism that processes approaching objects with priority...
  101. pmc Motor-related signals in the intraparietal cortex encode locations in a hybrid, rather than eye-centered reference frame
    O Dhaniel A Mullette-Gillman
    Brain Imaging and Analysis Center, Duke University, Durham, NC 27707, USA
    Cereb Cortex 19:1761-75. 2009
    ..Consequently, the overall hybrid nature of the reference frame was overlooked because the non-eye-centered response patterns were not fully characterized...

Research Grants66

  1. BEHAVIORAL & PHYSIOLOGICAL STUDIES OF SOUND LOCALIZATION
    TOM YIN; Fiscal Year: 2005
    ..long-term objective of this project is a thorough understanding of the behavioral and neural mechanisms of sound localization. Previous studies of sound localization have chiefly centered on two areas: human and animal psychophysical ..
  2. Human middle-ear imaging, physiology, and biomechanics
    CHARLES RICHARD STEELE; Fiscal Year: 2013
    ..restoration of hearing in the speech frequency range, and not in the higher frequencies where important sound localization cues are known to reside...
  3. Bilateral cochlear implants: Physiology and psychophysics
    Bertrand Delgutte; Fiscal Year: 2012
    ..While wearers of bilateral implants show improved sound localization and speech reception in noise, their ability to process interaural time differences (ITD) is still far from ..
  4. Presynaptic GABA-A receptor activation in auditory brainstem axon terminals
    CATHERINE JEANNE CHALENSKI WEISZ; Fiscal Year: 2013
    ..Research into the proper formation of neuronal circuits that encode sound localization is crucial for a greater understanding of hearing, both in animals and in humans...
  5. Multiple roles of inhibition in temporal coding of sensory information
    Ariel Lyons-Warren; Fiscal Year: 2012
    ..A temporal code uses precisely timed events to represent information. For example, sound localization in birds, mammals, and other vertebrates relies on temporal codes in which the events are spike times...
  6. Functional anatomy of the auditory system
    Brett R Schofield; Fiscal Year: 2013
    ..play a role in a wide variety of functions, including selective attention, learning, frequency selectivity, sound localization, and discrimination of speech sounds...
  7. Acoustic Behavior - Neural and Comparative Bases
    Ronald R Hoy; Fiscal Year: 2013
    ..This proposal focuses on microscale ears because physical constraints make sound localization and high sensitivity extraordinarily challenging with ears of microscale dimension...
  8. The role of short-term plasticity at the calyx of Held for auditory processing
    Yunxiang Chu; Fiscal Year: 2013
    ..called the calyx of Held, and to determine the functional importance of plasticity at this synapse for sound localization. The calyx of Held is a giant glutamatergic synapse in the auditory brainstem that functions as a fast ..
  9. Developmental effects of early hearing loss on auditory information processing
    Daniel J Tollin; Fiscal Year: 2013
    ..Of clinical significance, we will determine whether and how the altered neural information processing in the inferior colliculus is correlated with attributes of the binaural evoked potentials and sound localization behavior.
  10. Morphometric and physiologic analyses of the mammalian low frequency sound locali
    ARMIN HARRY SEIDL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Understanding the precise mechanisms underlying mammalian low frequency sound localization is of much interest for both clinical (detecting speech in noise) and fundamental neurobiology (computational)..
  11. MASKING IN THE AUDITORY SYSTEM
    Terry T Takahashi; Fiscal Year: 2012
    ..abstract_text> ..
  12. Coding of Auditory Space in the Avian Brain
    JOSE L PENA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): All auditory information used for sound localization ascends through the brainstem auditory nuclei...
  13. Binaural Sensitivity and Spatial Hearing in Bilateral Cochlear Implant Users
    Ruth Y Litovsky; Fiscal Year: 2013
    ..significant benefits from bilateral implantation, such as better speech-understanding in noise and improved sound localization. However, the performance of many patients is still notably worse than that of normal hearing (NH) listeners...
  14. Behavioral and physiological studies of sound localization
    Tom C T Yin; Fiscal Year: 2013
    ..provided by applicant): The overall aim of this project is to understand the neural mechanisms of sound localization. These results will help us understand how the brain integrates auditory information from the two ears and ..
  15. CRCNS: Coding for optimal performances in natural environments
    Terry T Takahashi; Fiscal Year: 2013
    ..This proposal investigates this issue by asking how the brain can approach statistical optimality in the sound localization system of barn owls...
  16. EphB signaling in deafferentation-induced auditory brainstem plasticity.
    PAUL ALAN NAKAMURA; Fiscal Year: 2012
    ..is part of the circuitry used for the computation of interaural intensity differences and is essential for sound localization. Following unilateral deafferentation during development, the intact VCN forms an additional aberrant ..
  17. CORE CENTER
    Robert J Dooling; Fiscal Year: 2012
    ..Existing projects include sound localization in bats and birds, prey-predator interactions in insects and bats, hair cell regeneration in fish and birds, ..
  18. Cellular basis of sound localization
    CATHERINE EMILY CARR; Fiscal Year: 2013
    ..provided by applicant): The broad goal of the proposed research program is to advance our understanding of sound localization. The noteworthy similarities and differences between sound location processing in birds and mammals clearly ..
  19. Information processing at auditory nerve synapses
    Matthew A Xu Friedman; Fiscal Year: 2011
    ..to changes in the timing information passed on by bushy cells to higher auditory centers, which may affect sound localization and processing...
  20. CRCNS: Optimality principles of auditory representations
    Kechen Zhang; Fiscal Year: 2013
    ..complex response properties in inferior colliculus and auditory cortex might arise from combining multiple sound localization cues at lower levels in the auditory pathway...
  21. Cross-modal changes in auditory cortex circuitry after visual deprivation
    EMILY ROSE PETRUS; Fiscal Year: 2013
    ..The loss of vision specifically can result in better tactile acuity, pitch discriminatin and sound localization in blind individuals...
  22. Behavioral Measures of Temporal Resolution in Mice With or Without Kv1.1 Subunits
    Micheal L Dent; Fiscal Year: 2010
    ..We will test the detection of simple sounds in quiet, the monaural temporal resolution acuity, and binaural sound localization accuracy...
  23. Wide-bandwidth open canal hearing aid for better multitalker speech understanding
    Sunil Puria; Fiscal Year: 2009
    ..fitting have been limited to providing audibility and comfort with no considerations being made to preserve sound localization cues...
  24. Development of Neuronal Circuits in the Auditory Systems
    Karl Kandler; Fiscal Year: 2013
    ..term goal of this research program is to elucidate these mechanisms in the lateral superior olive, a primary sound localization nucleus in the auditory brainstem of mammals...
  25. CORTICAL REPRESENTATION OF AUDITORY SPACE
    John C Middlebrooks; Fiscal Year: 2012
    ..spatial selectivity is enhanced in particular cortical areas that have been shown to be necessary for normal sound localization behavior. Specific Aim 2 will define the cortical mechanisms for spatial release from masking...
  26. Function and regulation of action potential bursts in the auditory system.
    Kevin J Bender; Fiscal Year: 2013
    Project summary: Circuits in the auditory brainstem dorsal cochlear nucleus (DCN) are believed to aid in sound localization in the vertical plane using monaural cues...
  27. Efferent inhibitory mechanisms in binaural processing
    R Michael Burger; Fiscal Year: 2013
    ..In both birds and mammals, the neural centers involved in sound localization receive inhibitory efferents from higher order nuclei...
  28. Synergistic in vivo and in vitro approaches in the MSO
    Nace L Golding; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Binaural cues are critical for speech perception and sound localization, and in recent years have become critical components of stimulation paradigms in auditory prostheses...
  29. Neuronal ensembles during development of tonotopic maps in the auditory systems
    Adrian Rodriguez-Contreras; Fiscal Year: 2013
    ..provided by applicant): PROJECT SUMMARY The medial nucleus of the trapezoid body (MNTB) plays a key role in sound localization by delivering fast and precise synaptic inhibition to auditory neurons in the mammalian brainstem...
  30. Buildup and Breakdown of Precedence in ITD and ILD
    ANDREW DENNIS BROWN; Fiscal Year: 2011
    ..Although the adaptive value of the precedence effect in sound localization is clear, important questions about the effect remain...
  31. Dendritic integration and synaptic plasticity in the MSO
    Nace L Golding; Fiscal Year: 2013
    ..Thus an understanding of how sound localization cues are processed in the MSO in turn requires knowledge of how the timing and strength of synaptic inputs ..
  32. Speech understanding and signal detection in noise in bilateral cochlear implants
    Matthew J Goupell; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The applicant's current research involves speech understanding and sound localization for unilateral and bilateral cochlear-implant (CI) users...
  33. Modulation of synaptic properties at the auditory Golgi-to-granule cell synapse
    DANIEL BOYD YAEGER; Fiscal Year: 2013
    ..The role of nonauditory input to the DCN is not understood, but it may play a role in sound localization by the DCN and in certain forms of the auditory disorder tinnitus...
  34. Speech understanding and signal detection in noise in bilateral cochlear implants
    Matthew J Goupell; Fiscal Year: 2013
    The proposed research aims to combine the areas of speech understanding, binaural hearing, sound localization, and cochlear implants (CIs)...
  35. Auditory and Visual Integration and Plasticity
    QI NANNAN CUI; Fiscal Year: 2010
    ..examine the relative contributions of eye position and cross-sensory experience on adaptive changes in sound localization after prism-induced shifts of visual space;and 3) elucidate novel adaptive mechanisms in sound localization ..
  36. The genesis of the neurophonic and its impact on coincidence detector neurons
    Joshua H Goldwyn; Fiscal Year: 2013
    ..These interaural time differences (ITDs) are a primary cue for sound localization. The earliest stage of the mammalian auditory pathway in which ITDs are computed is the medial superior ..
  37. Information Processing in the Inferior Colliculus
    ERIC DANIEL YOUNG; Fiscal Year: 2013
    ..Second, the way in which the three cues for sound localization are combined in neurons of the CNIC will be studied...
  38. AGE RELATED SYNAPTIC CHANGES IN THE AUDITORY BRAINSTEM
    Robert Helfert; Fiscal Year: 1999
    ..Neurons in the IC perform spatial and temporal coding of complex signals, sound localization, and are probably involved in the extraction of acoustic signals embedded in noise...
  39. Optimizing fitting of bilateral cochlear implants
    Matthew Fitzgerald; Fiscal Year: 2013
    ..2 will test the hypotheses that pitch- and loudness-matching procedures will enhance speech perception and sound localization abilities in experienced bilateral cochlear implant users. Experiment 3...
  40. DEVELOPMENT OF SOUND LOCALIZATION
    Catherine Carr; Fiscal Year: 2000
    ..This application is also supported by the chair of the Zoology department at the University of Maryland. ..
  41. INFORMATION PROCESSING BY THE AUDITORY SYSTEM
    WILLIAM YOST; Fiscal Year: 2002
    ..on complex sound processing like that associated with stimuli that generate a complex pitch perception and sound localization. The research is based on both behavioral and physiological (peripheral and central) techniques...
  42. SINGLE-CELL MARKING STUDIES OF THE AUDITORY NERVE
    David K Ryugo; Fiscal Year: 2010
    ..bilateral cochlear implants should enrich the acoustic experience by providing cues that contribute to sound localization. Better azimuthal sound localization skills should improve signal discrimination in noise, enhance sound ..
  43. Spatial Tuning in the Nucleus of the Brachium of the Inferior Colliculus
    SEAN JOSEPH SLEE; Fiscal Year: 2013
    ..The results of this study will elucidate the neural mechanisms underlying the integration of sound localization cues necessary for the formation of objects in the ascending auditory system...
  44. Cortical Sensitivity to Acoustic Cues for Sound Location
    EWAN MACPHERSON; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Sound localization is a fundamental task of the auditory system, and in higher mammals, requires an intact auditory cortex...
  45. ACTIVITY OF AI NEURONS IN LOCALIZING SOUNDS
    Gregg Recanzone; Fiscal Year: 2000
    ..An apparent paradox exists, where lesions of the auditory cortex result in profound sound localization deficits, but the spatial selectivity of most cells in auditory cortex are an order of magnitude greater ..
  46. NEURAL MECHANISMS OF SOUND LOCALIZATION
    Zhongmin Lu; Fiscal Year: 2007
    The long-term goal of the Pi's research is to understand neural mechanisms of sound localization in vertebrates, including humans...
  47. COINCIDENCE DETECTION MODELS IN AUDITORY BRAINSTEM
    Jonathan Simon; Fiscal Year: 2003
    ..The long-term objective of this research is to characterize coincidence-detector neurons used for binaural sound localization in the avian and mammalian brainstem, using computational, biophysically accurate, models of individual ..
  48. COMPARATIVE ASPECTS OF SOUND LOCALIZATION
    ROBERT DOOLING; Fiscal Year: 1990
    Birds present an interesting dilemma for classical theories of sound localization. Because of their restricted range of hearing and closely-spaced ears, it is difficult to understand how birds can localize sound at all...
  49. AUDITORY BASIS FOR VERTICAL SOUND LOCALIZATION
    JAMES SIMMONS; Fiscal Year: 1992
    ..Such a mechanisms associated with sound localization in a mammal may have clinical significance as an instance of plasticity in an adult, with implications for ..
  50. INTRINSIC INHIBITION IN THE COCHLEAR NUCLEAR COMPLEX
    ROBERT WICKESBERG; Fiscal Year: 2000
    ..have pointed to the cochlear nuclei as the site of a process that reduces the information available for sound localization shortly after the onset of a sound and contributes to the precedence effect...
  51. STRUCTURE OF PRIMARY AUDITORY CORTEX
    JEFFERY WINER; Fiscal Year: 1993
    ..These pathways play a critical role in the normal flow of auditory information related to sound localization or the analysis of speech, and damage to them produces a spectrum of neurobehavioral dysfunctions not ..
  52. Cerebral Control of Sound Localization
    Shveta Malhotra; Fiscal Year: 2007
    ..In addition, regions of auditory cortex not already implicated in sound localization will also be examined for contributions to the discrimination of moving sounds to determine if a specific ..
  53. NEURAL ENCODING OF DYNAMIC FEATURES OF COMPLEX SOUNDS
    Robert Frisina; Fiscal Year: 1992
    ..components of many human and animal communication sounds, and in some cases mediate pitch perception and sound localization. The specific aims of the present proposal are to rigorously investigate the responses of single cells in ..
  54. EVOLUTION OF SENSORY SYSTEMS
    Rickye Heffner; Fiscal Year: 2000
    ..It embarks on a comparative survey of hearing and passive sound localization in bats...
  55. Cochlear Nucleus Proteomics in a Mouse Model of Age-Related Hearing Loss
    Xian Chen; Fiscal Year: 2007
    ..cells in the cochlear nucleus that are involved in processing and transmitting timing information used for sound localization and some aspects of speech perception have altered synaptic function and electrical excitability in deaf ..
  56. Auditory Brainstem Development and Plasticity
    CANDACE HSIEH; Fiscal Year: 2007
    ..This circuitry is essential for the computation of interaural intensity differences used in sound localization. In gerbils, after deafferentation, the ipsilateral AVCN undergoes cell death and the intact AVCN innervates ..
  57. COMPARATIVE STUDY OF SOUND LOCALIZATION
    Rickye Heffner; Fiscal Year: 1992
    The proposed project is a comparative study of mammalian hearing with emphasis on sound localization. The long-range goals are to determine the ecological, morphological, and physiological correlates of the variation in hearing and sound ..
  58. NEUROPHYSIOLOGY OF SOUND LOCALIZATION
    Masakazu Konishi; Fiscal Year: 2006
    ..Barn owls are particularly suitable for the study of brain mechanisms of sound localization. They use the interaural time difference for localization in the left-right direction and the interaural ..
  59. CELLULAR MECHANISMS UNDERLYING SOUND LOCALIZATION
    Catherine Carr; Fiscal Year: 1992
    ..barn owl, and is also where sensitivity first appears to the interaural temporal disparities which underlie sound localization. The analysis of temporally ordered inputs is integral to information processing in the brain, and ..
  60. NEURAL MECHANISMS OF SOUND LOCALIZATION
    Andrew Moiseff; Fiscal Year: 1991
    ..Although the basic principles of sound localization are starting to be understood, the datails of how the brain accomplishes this task are largely unknown...
  61. NONLINEAR DYNAMICS OF NEURONAL TEMPORAL PROCESSING
    John Rinzel; Fiscal Year: 2004
    ..b>Sound localization in the auditory system offers a compelling example...
  62. Glutamate in Development of Auditory Brainstem
    DEDA GILLESPIE; Fiscal Year: 2005
    The lateral superior olive (LSO), a binaural nucleus involved in sound localization, receives converging excitatory and inhibitory projections that are precisely tonotopically matched...
  63. Information Transfer at Auditory Nerve Synapses
    MATTHEW XU FRIEDMAN; Fiscal Year: 2005
    ..impact on the bushy cell's behavioral role of relaying and improving the timing of auditory nerve spikes for sound localization; however, the kinetics of these changes are not well understood under physiological conditions...
  64. MONAURAL AND BINAURAL MECHANISMS OF DIRECTIONAL HEARING
    THOMAS IMIG; Fiscal Year: 1999
    ..This is a continuation of research attempting to identify neural substrates of sound localization relevant to human hearing...
  65. NEURONS AND CIRCUITS OF PERIOLIVARY NUCLEI
    ALBERT BERREBI; Fiscal Year: 1999
    ..olive, lateral superior olive and medical nucleus of the trapezoid body, which have identified roles in sound localization. These principal nuclei are surrounded by a sphere of accessory cell groups, collectively known as ..
  66. HEARING PROTECTOR ALLOWING ACOUSTIC COMMUNICATION
    PATRICK ZUREK; Fiscal Year: 2002
    ..In addition, the signal processing allows the preservation of sound localization ability...