reversal learning

Summary

Summary: Any situation where an animal or human is trained to respond differentially to two stimuli (e.g., approach and avoidance) under reward and punishment conditions and subsequently trained under reversed reward values (i.e., the approach which was previously rewarded is punished and vice versa).

Top Publications

  1. ncbi Defining the neural mechanisms of probabilistic reversal learning using event-related functional magnetic resonance imaging
    Roshan Cools
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 22:4563-7. 2002
  2. ncbi Abstract reward and punishment representations in the human orbitofrontal cortex
    M L Kringelbach
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX1 3UD, UK
    Nat Neurosci 4:95-102. 2001
  3. pmc Striatal dopamine predicts outcome-specific reversal learning and its sensitivity to dopaminergic drug administration
    Roshan Cools
    Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Neurosci 29:1538-43. 2009
  4. ncbi Reduced orbitofrontal-striatal activity on a reversal learning task in obsessive-compulsive disorder
    Peter L Remijnse
    Department of Psychiatry, VU University Medical Center, Graduate School of Neurosciences, and Outpatient Academic Clinic for Anxiety Disorders, GGZ Buitenamstel, Amsterdam, The Netherlands
    Arch Gen Psychiatry 63:1225-36. 2006
  5. ncbi Ventromedial frontal cortex mediates affective shifting in humans: evidence from a reversal learning paradigm
    Lesley K Fellows
    Center for Cognitive Neuroscience, University of Pennsylvania, 3815 Walnut St, Philadelphia, PA 19104 6196, USA
    Brain 126:1830-7. 2003
  6. ncbi Reward-related reversal learning after surgical excisions in orbito-frontal or dorsolateral prefrontal cortex in humans
    J Hornak
    University of Oxford, Oxford, UK
    J Cogn Neurosci 16:463-78. 2004
  7. ncbi Dopamine release in dissociable striatal subregions predicts the different effects of oral methylphenidate on reversal learning and spatial working memory
    Philip L Clatworthy
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 29:4690-6. 2009
  8. ncbi Prefrontal serotonin depletion affects reversal learning but not attentional set shifting
    H F Clarke
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 25:532-8. 2005
  9. ncbi Ventral striatum response during reward and punishment reversal learning in unmedicated major depressive disorder
    Oliver J Robinson
    Section on Neuroimaging in Mood and Anxiety Disorders, NIMH, Bethesda, MD, USA
    Am J Psychiatry 169:152-9. 2012
  10. pmc Differences in BTBR T+ tf/J and C57BL/6J mice on probabilistic reversal learning and stereotyped behaviors
    Dionisio A Amodeo
    Department of Psychology, 1007 West Harrison Street, University of Illinois at Chicago, Chicago, IL 60607, USA
    Behav Brain Res 227:64-72. 2012

Detail Information

Publications251 found, 100 shown here

  1. ncbi Defining the neural mechanisms of probabilistic reversal learning using event-related functional magnetic resonance imaging
    Roshan Cools
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 22:4563-7. 2002
    ..The signal change in this ventral frontostriatal circuit is therefore associated with reversal learning and is uncontaminated by negative feedback...
  2. ncbi Abstract reward and punishment representations in the human orbitofrontal cortex
    M L Kringelbach
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX1 3UD, UK
    Nat Neurosci 4:95-102. 2001
    ..These findings indicate that one emotional involvement of the human orbitofrontal cortex is its representation of the magnitudes of abstract rewards and punishments, such as receiving or losing money...
  3. pmc Striatal dopamine predicts outcome-specific reversal learning and its sensitivity to dopaminergic drug administration
    Roshan Cools
    Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Neurosci 29:1538-43. 2009
    ..We demonstrate that individual differences in reward-based reversal learning reflect variation in baseline striatal dopamine synthesis capacity, as measured with neurochemical positron ..
  4. ncbi Reduced orbitofrontal-striatal activity on a reversal learning task in obsessive-compulsive disorder
    Peter L Remijnse
    Department of Psychiatry, VU University Medical Center, Graduate School of Neurosciences, and Outpatient Academic Clinic for Anxiety Disorders, GGZ Buitenamstel, Amsterdam, The Netherlands
    Arch Gen Psychiatry 63:1225-36. 2006
    ..However, the engagement of this neural loop in OCD has not been tested directly in a cognitive activation imaging paradigm so far...
  5. ncbi Ventromedial frontal cortex mediates affective shifting in humans: evidence from a reversal learning paradigm
    Lesley K Fellows
    Center for Cognitive Neuroscience, University of Pennsylvania, 3815 Walnut St, Philadelphia, PA 19104 6196, USA
    Brain 126:1830-7. 2003
    ..In monkeys, this ability--a form of affective shifting known as reversal learning--depends on orbitofrontal cortex...
  6. ncbi Reward-related reversal learning after surgical excisions in orbito-frontal or dorsolateral prefrontal cortex in humans
    J Hornak
    University of Oxford, Oxford, UK
    J Cogn Neurosci 16:463-78. 2004
    ....
  7. ncbi Dopamine release in dissociable striatal subregions predicts the different effects of oral methylphenidate on reversal learning and spatial working memory
    Philip L Clatworthy
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 29:4690-6. 2009
    ..Methylphenidate produced significantly different effects on reversal learning and spatial working memory tasks within individuals...
  8. ncbi Prefrontal serotonin depletion affects reversal learning but not attentional set shifting
    H F Clarke
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 25:532-8. 2005
    ....
  9. ncbi Ventral striatum response during reward and punishment reversal learning in unmedicated major depressive disorder
    Oliver J Robinson
    Section on Neuroimaging in Mood and Anxiety Disorders, NIMH, Bethesda, MD, USA
    Am J Psychiatry 169:152-9. 2012
    ..Depression is associated, for example, with a negative affective bias in reversal learning. However, despite the fact that reversal learning is associated with striatal response in healthy ..
  10. pmc Differences in BTBR T+ tf/J and C57BL/6J mice on probabilistic reversal learning and stereotyped behaviors
    Dionisio A Amodeo
    Department of Psychology, 1007 West Harrison Street, University of Illinois at Chicago, Chicago, IL 60607, USA
    Behav Brain Res 227:64-72. 2012
    ..The present experiment investigated performance of BTBR T+ tf/J and C57BL/6J on two different spatial reversal learning tests (100% accurate feedback and 80/20 probabilistic feedback), as well as marble burying and grooming ..
  11. ncbi Contrasting cortical and subcortical activations produced by attentional-set shifting and reversal learning in humans
    R D Rogers
    University of Cambridge and Medical Research Council, United Kingdom
    J Cogn Neurosci 12:142-62. 2000
    ..By contrast, reversal learning, relative to ID shift learning, produced activations of the left caudate nucleus...
  12. ncbi Inactivation of the medial prefrontal cortex of the rat impairs strategy set-shifting, but not reversal learning, using a novel, automated procedure
    Stan B Floresco
    Department of Psychology and Brain Research Centre, University of British Columbia, 2136 West Mall, Vancouver, B C, Canada
    Behav Brain Res 190:85-96. 2008
    ..In the present study, we assessed the effects of inactivation of the mPFC on strategy set-shifting and reversal learning, using a novel, automated procedure conducted in an operant chamber...
  13. pmc Abnormal ventromedial prefrontal cortex function in children with psychopathic traits during reversal learning
    Elizabeth C Finger
    National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Arch Gen Psychiatry 65:586-94. 2008
    ..traits and conduct or oppositional defiant disorder demonstrate poor decision making and are impaired in reversal learning. However, the neural basis of this impairment has not previously been investigated...
  14. ncbi The neuropsychology of ventral prefrontal cortex: decision-making and reversal learning
    L Clark
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Brain Cogn 55:41-53. 2004
    ..studies implicates overlapping neural circuitry in ventral prefrontal cortex in decision-making and reversal learning. The ascending 5-HT and dopamine neurotransmitter systems have a modulatory role in both processes...
  15. pmc Lesions of the medial striatum in monkeys produce perseverative impairments during reversal learning similar to those produced by lesions of the orbitofrontal cortex
    Hannah F Clarke
    Department of Experimental Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB23EB, United Kingdom
    J Neurosci 28:10972-82. 2008
    ....
  16. pmc Paradoxical reversal learning enhancement by stress or prefrontal cortical damage: rescue with BDNF
    Carolyn Graybeal
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Neurosci 14:1507-9. 2011
    Stress affects various forms of cognition. We found that moderate stress enhanced late reversal learning in a mouse touchscreen-based choice task...
  17. ncbi Neural circuits subserving behavioral flexibility and their relevance to schizophrenia
    Stan B Floresco
    Department of Psychology and Brain Research Centre, University of British Columbia, 2136 West Mall, Vancouver, B C V6T 1Z4, Canada
    Behav Brain Res 204:396-409. 2009
    Impairments in different forms of behavioral flexibility, such as set-shifting and reversal learning, are some of the most reliable cognitive deficits associated with schizophrenia, and have been attributed to a disruption in frontal ..
  18. pmc Impaired probabilistic reversal learning in youths with mood and anxiety disorders
    D P Dickstein
    National Institute of Mental Health NIMH Mood and Anxiety Disorders Program
    Psychol Med 40:1089-100. 2010
    ..b>Reversal learning is one such process, whereby subjects must first acquire stimulus/reward and stimulus/punishment ..
  19. pmc Selective inactivation of adenosine A(2A) receptors in striatal neurons enhances working memory and reversal learning
    Catherine J Wei
    Molecular Neuropharmacology Laboratory, Department of Neurology, Boston University School of Medicine, Massachusetts 02118, USA
    Learn Mem 18:459-74. 2011
    ..KO) or to striatum alone (st-A(2A)R KO) in recognition memory, working memory, reference memory, and reversal learning. This comprehensive, comparative analysis showed for the first time that depletion of A(2A)R-dependent ..
  20. pmc Dopamine, but not serotonin, regulates reversal learning in the marmoset caudate nucleus
    Hannah F Clarke
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 31:4290-7. 2011
    Studies of visual discrimination reversal learning have revealed striking neurochemical dissociations at the level of the orbitofrontal cortex (OFC) with serotoninergic, but not dopaminergic, integrity being important for successful ..
  21. pmc Dissociable roles for lateral orbitofrontal cortex and lateral prefrontal cortex during preference driven reversal learning
    Adam Hampshire
    Medical Research Council Cognition and Brain Sciences Unit, Chaucer Road, Cambridge, UK
    Neuroimage 59:4102-12. 2012
    One of the archetypal task manipulations known to depend on frontal-lobe function is reversal learning, where a dominant response must be overridden due to changes in the contingencies relating stimuli, responses, and environmental ..
  22. pmc Reversal learning as a measure of impulsive and compulsive behavior in addictions
    Alicia Izquierdo
    Department of Psychology, California State University, Los Angeles, 5151 State University Drive, Los Angeles, CA 90032, USA
    Psychopharmacology (Berl) 219:607-20. 2012
    ..One task in particular, reversal learning, has proven valuable in assessing the inhibitory processes that are central to executive control...
  23. pmc No trade-off between learning speed and associative flexibility in bumblebees: a reversal learning test with multiple colonies
    Nigel E Raine
    Biological and Experimental Psychology Group, School of Biological and Chemical Sciences, Queen Mary, University of London, London, United Kingdom
    PLoS ONE 7:e45096. 2012
    ..Here, we test whether rapid learning interferes with the acquisition of new information using a reversal learning paradigm. Bumblebees (Bombus terrestris) were trained to associate yellow with a floral reward...
  24. ncbi Selective bilateral amygdala lesions in rhesus monkeys fail to disrupt object reversal learning
    Alicia Izquierdo
    Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 27:1054-62. 2007
    ..is that bilateral aspirative or radiofrequency lesions of the amygdala yield severe impairments on object reversal learning, a task that assesses the ability to shift choices of objects based on the presence or absence of food ..
  25. ncbi Hippocampal long-term depression mediates spatial reversal learning in the Morris water maze
    Zhifang Dong
    Ministry of Education Key Laboratory of Child Development and Disorders, Children s Hospital of Chongqing Medical University, Chongqing 400014, PR China
    Neuropharmacology 64:65-73. 2013
    ..administration of these two mechanistically and structurally distinct inhibitors impaired spatial reversal learning of a novel target location, when the hidden platform was moved to the quadrant opposite the initial target ..
  26. pmc Differential brain activity during emotional versus nonemotional reversal learning
    Kaoru Nashiro
    University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089 0191, USA
    J Cogn Neurosci 24:1794-805. 2012
    ..This ability has been examined in reversal learning tasks, where participants first learn a stimulus-response association (e.g...
  27. pmc Discrimination reversal and attentional sets in zebrafish (Danio rerio)
    Matthew O Parker
    School of Biological and Chemical Sciences, Queen Mary University of London, London E1 4NS, UK
    Behav Brain Res 232:264-8. 2012
    ..b>Reversal learning deficits have been implicated in a variety of human psychological disorders (e.g...
  28. ncbi The role of the ventromedial prefrontal cortex in abstract state-based inference during decision making in humans
    Alan N Hampton
    Computation and Neural Systems Program, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 26:8360-7. 2006
    ..imaging while they performed a simple decision-making task with higher-order structure, probabilistic reversal learning. We found that neural activity in a key decision-making region, the vmPFC, was more consistent with a ..
  29. pmc Differential contributions of the primate ventrolateral prefrontal and orbitofrontal cortex to serial reversal learning
    Rafal Rygula
    Department of Experimental Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 30:14552-9. 2010
    ..of analogous regions in marmosets have revealed, however, that although the OFC is indeed critical for reversal learning, ventrolateral prefrontal cortex (VLPFC) (analogous to IFG) is not, contributing instead to higher order ..
  30. ncbi Feedback-related negativity codes prediction error but not behavioral adjustment during probabilistic reversal learning
    Henry W Chase
    University of Cambridge, UK
    J Cogn Neurosci 23:936-46. 2011
    ..over the medial frontal cortex (MFC) during outcome-based behavioral adjustment using a probabilistic reversal learning task...
  31. ncbi Anatomy of a decision: striato-orbitofrontal interactions in reinforcement learning, decision making, and reversal
    Michael J Frank
    Department of Psychology, University of Colorado at Boulder, Boulder, CO, USA
    Psychol Rev 113:300-26. 2006
    ..The model successfully captures patterns of behavior resulting from OFC damage in decision making, reversal learning, and devaluation paradigms and makes additional predictions for the underlying source of these deficits.
  32. pmc Associative encoding in anterior piriform cortex versus orbitofrontal cortex during odor discrimination and reversal learning
    Matthew R Roesch
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Cereb Cortex 17:643-52. 2007
    ....
  33. ncbi Differential frontal-striatal and paralimbic activity during reversal learning in major depressive disorder and obsessive-compulsive disorder
    P L Remijnse
    Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    Psychol Med 39:1503-18. 2009
    Several lines of research suggest a disturbance of reversal learning (reward and punishment processing, and affective switching) in patients with major depressive disorder (MDD)...
  34. ncbi A GABAergic inhibitory neural circuit regulates visual reversal learning in Drosophila
    Qingzhong Ren
    Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Neurosci 32:11524-38. 2012
    ..processing and behavior to dynamically changing environmental contingencies has been studied using the reversal learning paradigm in mammals, but the complexity of the brain circuits precludes a detailed analysis of the ..
  35. ncbi The GABAergic anterior paired lateral neurons facilitate olfactory reversal learning in Drosophila
    Yanying Wu
    Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Learn Mem 19:478-86. 2012
    b>Reversal learning has been widely used to probe the implementation of cognitive flexibility in the brain. Previous studies in monkeys identified an essential role of the orbitofrontal cortex (OFC) in reversal learning...
  36. pmc 5-HT2A receptors in the orbitofrontal cortex facilitate reversal learning and contribute to the beneficial cognitive effects of chronic citalopram treatment in rats
    Ashley Furr
    Department of Pharmacology, Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX, USA
    Int J Neuropsychopharmacol 15:1295-305. 2012
    ..to investigate the potential modulatory influence specifically of 5-HT2A receptors (5-HT2ARs) in the OFC on reversal learning, and their potential contribution to the beneficial cognitive effects of chronic SSRI treatment...
  37. ncbi Enhancement of spatial reversal learning by 5-HT2C receptor antagonism is neuroanatomically specific
    Vasileios Boulougouris
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 30:930-8. 2010
    ..administration of 5-HT(2C) and 5-HT(2A) receptor antagonists significantly enhanced and impaired spatial reversal learning, respectively...
  38. ncbi Role of 5-HT receptor mechanisms in sub-chronic PCP-induced reversal learning deficits in the rat
    Samantha L McLean
    Bradford School of Pharmacy, University of Bradford, Bradford, West Yorkshire BD7 1DP, UK
    Psychopharmacology (Berl) 206:403-14. 2009
    ..5-HT receptor mechanisms have been suggested to mediate improvements in cognition in schizophrenia...
  39. pmc Dissociable responses to punishment in distinct striatal regions during reversal learning
    Oliver J Robinson
    Department of Psychiatry and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, Addenbrooke s Hospital, P O Box 189, Level E4, Hills Road, Cambridge, CB2 2QQ, UK
    Neuroimage 51:1459-67. 2010
    ..For instance, how can significant BOLD responses in the ventral striatum during punishment-based reversal learning be reconciled with the frequently demonstrated role of the ventral striatum in reward processing? Here we ..
  40. ncbi Context-specific interference on reversal learning of a stimulus-response habit
    R J McDonald
    Department of Psychology, University of Toronto, 100 St. George Street, Toronto, ON, Canada M5S-3G3
    Behav Brain Res 121:149-65. 2001
    ..underlying the importance of context information and its role in expression of discrimination learning and reversal learning. Rats were trained on a stimulus-response (S-R) habit task designed for the eight-arm radial maze and after ..
  41. ncbi Parsing decision making processes in prefrontal cortex: response inhibition, overcoming learned avoidance, and reversal learning
    Steven G Greening
    Department of Anatomy and Cell Biology, The University of Western Ontario, London, Ontario, Canada
    Neuroimage 54:1432-41. 2011
    b>Reversal learning refers to the ability to inhibit or switch responding to an object when the object-reward contingency changes...
  42. ncbi Attenuation of context-specific inhibition on reversal learning of a stimulus-response task in rats with neurotoxic hippocampal damage
    Robert J McDonald
    Department of Psychology, University of Toronto, 100 St George Street, Ont, Canada M5S 3G3
    Behav Brain Res 136:113-26. 2002
    ..b>Reversal learning in rats with hippocampal lesions was faster than sham animals in the same context suggesting that the ..
  43. ncbi Impairments in timing, temporal memory, and reversal learning linked to neurotoxic regimens of methamphetamine intoxication
    Ruey Kuang Cheng
    Department of Psychology and Neuroscience, 572 Research Drive, Duke University, Durham, NC 27708, USA
    Brain Res 1186:255-66. 2007
    ..indicate that MAP intoxication leads to reduced auditory/visual differences in clock speed, deficits in reversal learning, distortions in temporal memory, and lowered dopaminergic regulation of clock speed consistent with damage ..
  44. ncbi Teaching old rats new tricks: age-related impairments in olfactory reversal learning
    Geoffrey Schoenbaum
    Department of Psychological and Brain Sciences, Johns Hopkins University, 3400 North Charles Street, 25 Ames Hall, Baltimore, MD 21218, USA
    Neurobiol Aging 23:555-64. 2002
    ..was no correlation between reversal performance and spatial learning in the aged rats, indicating that the reversal learning impairment was not related to decline in medial temporal lobe function...
  45. pmc Differential involvement of hippocampal calcineurin during learning and reversal learning in a Y-maze task
    Robbert Havekes
    Department of Molecular Neurobiology, University of Groningen, Haren 9750 AA, The Netherlands
    Learn Mem 13:753-9. 2006
    ..Moreover, reversal training selectively affects hippocampal CA3 and CA1 regions, suggesting a specific function of these hippocampal subregions in reversal learning.
  46. pmc Sexually dimorphic alterations in locomotion and reversal learning after adolescent tetrahydrocannabinol exposure in the rat
    Lauren C Harte
    Department of Physiology Pharmacology, Program in Neural and Behavioral Sciences, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Neurotoxicol Teratol 32:515-24. 2010
    ....
  47. ncbi Disruptive effects of the prototypical cannabinoid Δ⁹-tetrahydrocannabinol and the fatty acid amide inhibitor URB-597 on go/no-go auditory discrimination performance and olfactory reversal learning in rats
    Ljiljana Sokolic
    School of Psychology, Concord Centre for Mental Health, University of Sydney, New South Wales, Australia
    Behav Pharmacol 22:191-202. 2011
    ..These results confirm impairment of cognitive flexibility (reversal learning) by cannabinoids and show remarkable sensitivity of auditory discrimination performance to Δ⁹-THC and the ..
  48. pmc Dopamine precursor depletion improves punishment prediction during reversal learning in healthy females but not males
    Oliver J Robinson
    Department of Psychiatry and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, Addenbrooke s Hospital, P O Box 189, Level E4, Hills Road, Cambridge, CB2 2QQ, UK
    Psychopharmacology (Berl) 211:187-95. 2010
    ..patients with Parkinson's disease and healthy individuals with low dopamine (DA) synthesis are better at reversal learning based on punishment than reward...
  49. pmc Amygdala and orbitofrontal cortex lesions differentially influence choices during object reversal learning
    Peter H Rudebeck
    Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:8338-43. 2008
    ..published data from groups of monkeys with either OFC or AMG lesions that had been tested on an object reversal learning task. Based on trial-by-trial analyses of rewarded and unrewarded choices, we report two new findings...
  50. ncbi Sub-chronic psychotomimetic phencyclidine induces deficits in reversal learning and alterations in parvalbumin-immunoreactive expression in the rat
    Z Abdul-Monim
    Bradford School of Pharmacy, University of Bradford, Bradford, UK
    J Psychopharmacol 21:198-205. 2007
    ....
  51. pmc Reconciling the roles of orbitofrontal cortex in reversal learning and the encoding of outcome expectancies
    Geoffrey Schoenbaum
    Department of AAnatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Ann N Y Acad Sci 1121:320-35. 2007
    ..Such deficits are epitomized by impairments in reversal learning. Historically, reversal learning deficits have been linked to a response inhibition function or to the rapid ..
  52. ncbi Prelimbic/infralimbic inactivation impairs memory for multiple task switches, but not flexible selection of familiar tasks
    Erin L Rich
    Fishberg Department of Neuroscience and Alfred B and Gudrun J Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Neurosci 27:4747-55. 2007
    ..Thus, although PL/IL activity contributed to memory for multiple task switches, it was not required for flexibly selecting among highly familiar tasks...
  53. ncbi L-DOPA disrupts activity in the nucleus accumbens during reversal learning in Parkinson's disease
    Roshan Cools
    Department of Experimental Psychology, Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 32:180-9. 2007
    ..dopaminergic medication in Parkinson's disease may impair certain aspects of cognitive function, such as reversal learning. We used functional magnetic resonance imaging in patients with mild Parkinson's disease to investigate the ..
  54. pmc Probabilistic reversal learning is impaired in Parkinson's disease
    D A Peterson
    Institute for Neural Computation, University of California San Diego, CA, USA
    Neuroscience 163:1092-101. 2009
    ..Nat Neurosci 9:1057-1063] for use as a reversal learning task with humans...
  55. ncbi Dissociable contributions of the orbitofrontal and infralimbic cortex to pavlovian autoshaping and discrimination reversal learning: further evidence for the functional heterogeneity of the rodent frontal cortex
    Y Chudasama
    Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom CB2 3EB
    J Neurosci 23:8771-80. 2003
    ..the orbitofrontal cortex (OFC) and the infralimbic cortex (ILC) on pavlovian autoshaping and discrimination reversal learning. During the pavlovian autoshaping task, in which rats learn to approach a stimulus predictive of reward [..
  56. ncbi Relationship between limbic and cortical 5-HT neurotransmission and acquisition and reversal learning in a go/no-go task in rats
    Daiki Masaki
    Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Psychopharmacology (Berl) 189:249-58. 2006
    ..Central serotonin (5-HT) function has also been widely implicated in impulsivity; however, little research has addressed the regional aspect of 5-HT roles in different impulsive indices of task performance...
  57. pmc Selective lesions of the dorsomedial striatum impair serial spatial reversal learning in rats
    Anna Castañé
    Department of Experimental Psychology and Behavioural and Clinical Neuroscience Institute BCNI, University of Cambridge, CB2 3EB, Cambridge, United Kingdom
    Behav Brain Res 210:74-83. 2010
    Impairments in reversal learning have been attributed to orbitofrontal cortex (OFC) dysfunction in many species. However, the role of subcortical areas interconnected with the OFC such as the striatum remains poorly understood...
  58. ncbi DARPP-32 knockout mice exhibit impaired reversal learning in a discriminated operant task
    C J Heyser
    Department of Psychology, Franklin and Marshall College, P O Box 3003, Lancaster, PA 17604, USA
    Brain Res 867:122-30. 2000
    ..At the completion of extensive operant training, reversal learning was assessed...
  59. ncbi Acute delta9-tetrahydrocannabinol-induced deficits in reversal learning: neural correlates of affective inflexibility
    Alice Egerton
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, Glasgow, Scotland, UK
    Neuropsychopharmacology 30:1895-905. 2005
    ..These findings suggest that marijuana use may produce inelasticity in updating affective associations between stimuli and reinforcement value, and that this effect may arise through dysregulation of orbitofrontal and striatal circuitry...
  60. ncbi Improved short-term spatial memory but impaired reversal learning following the dopamine D(2) agonist bromocriptine in human volunteers
    M A Mehta
    Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke s Hospital, UK
    Psychopharmacology (Berl) 159:10-20. 2001
    ..Studies in humans of cognitive effects of dopaminergic drugs have largely focused on tasks of working memory, with a few studies also examining executive function...
  61. ncbi The cerebellum is involved in reward-based reversal learning
    Patrizia Thoma
    Institute of Cognitive Neuroscience, Department of Neuropsychology, Faculty of Psychology, Ruhr University of Bochum, 44780 Bochum, Germany
    Cerebellum 7:433-43. 2008
    ..Cerebellar patients showed intact acquisition of stimulus contingencies, while reward-based reversal learning was significantly impaired...
  62. pmc Neural correlates of reversal learning in severe mood dysregulation and pediatric bipolar disorder
    Nancy E Adleman
    National Institute of Mental Health NIMH, National Institutes of Health NIH, Department of Health and Human Services, USA
    J Am Acad Child Adolesc Psychiatry 50:1173-1185.e2. 2011
    ..Functional magnetic resonance imaging was used to examine neural correlates of cognitive flexibility deficits in patients with SMD and BD versus healthy volunteers (HV)...
  63. pmc Chronic intermittent cold stress and serotonin depletion induce deficits of reversal learning in an attentional set-shifting test in rats
    M Danet S Lapiz-Bluhm
    Department of Pharmacology, MC 7764, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Psychopharmacology (Berl) 202:329-41. 2009
    ..Orbitofrontal cortex (OFC) has been implicated specifically in reversal learning, a form of cognitive flexibility modulated by 5-HT.
  64. ncbi Impairments in visual discrimination learning and recognition memory produced by neurotoxic lesions of rhinal cortex in rhesus monkeys
    M G Baxter
    Department of Psychology, Harvard University, 906 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
    Eur J Neurosci 13:1228-38. 2001
    ..discrimination learning as well as recognition memory performance postoperatively, although reliable reversal learning impairments were not observed...
  65. pmc Enhanced cognitive flexibility in reversal learning induced by removal of the extracellular matrix in auditory cortex
    Max F K Happel
    Department of Systems Physiology of Learning and Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, D 39118 Magdeburg, Germany
    Proc Natl Acad Sci U S A 111:2800-5. 2014
    ..The cognitive flexibility required for reversal learning of previously acquired behavioral habits, commonly understood to mainly rely on frontostriatal circuits, was ..
  66. ncbi Enhanced or impaired cognitive function in Parkinson's disease as a function of dopaminergic medication and task demands
    R Cools
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Cereb Cortex 11:1136-43. 2001
    ..By contrast, the same medication impaired probabilistic reversal learning that implicates orbitofrontal cortex- ventral striatal circuitry, which is relatively spared of DA loss in ..
  67. ncbi Effects of selective thalamic and prelimbic cortex lesions on two types of visual discrimination and reversal learning
    Y Chudasama
    School of Psychology, Cardiff University, PO Box 901, Cardiff, Wales, CF10 3YG, UK
    Eur J Neurosci 14:1009-20. 2001
    ..the anterior thalamic nuclei and of the prelimbic cortex were examined on two tests of discrimination and reversal learning. In experiment 1A (visual discrimination and reversal), rats were required to discriminate two stimuli, and ..
  68. ncbi Loss of hippocampal neurogenesis, increased novelty-induced activity, decreased home cage activity, and impaired reversal learning one year after irradiation of the young mouse brain
    Marie Kalm
    Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Box 432, SE 405 30, Gothenburg, Sweden
    Exp Neurol 247:402-9. 2013
    ..Place learning in the IntelliCage was unaffected by irradiation but reversal learning was impaired...
  69. ncbi Differential effects of inactivation of the orbitofrontal cortex on strategy set-shifting and reversal learning
    Sarvin Ghods-Sharifi
    Department of Psychology and Brain Research Center, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4
    Neurobiol Learn Mem 89:567-73. 2008
    ..example, lesions of the medial or orbitofrontal (OFC) regions of the PFC impair extradimensional shifts and reversal learning, respectively, when novel stimuli are used during different phases of the task...
  70. ncbi Brief social isolation in early adolescence affects reversal learning and forebrain BDNF expression in adult rats
    Xiao Han
    Department of Psychology, Peking University, Beijing, China
    Brain Res Bull 86:173-8. 2011
    ..We found that early isolation rearing affected reversal learning without interfering with spatial learning in the Morris water maze...
  71. pmc A reversal learning task detects cognitive deficits in a Dachshund model of late-infantile neuronal ceroid lipofuscinosis
    D N Sanders
    Mason Eye Institute, University of Missouri School of Medicine, Columbia, MO 65212, USA
    Genes Brain Behav 10:798-804. 2011
    ..Cognitive function was assessed using a T-maze reversal learning (RL) task...
  72. ncbi Serial reversal learning and the evolution of behavioral flexibility in three species of North American corvids (Gymnorhinus cyanocephalus, Nucifraga columbiana, Aphelocoma californica)
    Alan B Bond
    School of Biological Sciences, University of Nebraska, Lincoln, NE 68588 0118, USA
    J Comp Psychol 121:372-9. 2007
    In serial reversal learning, subjects learn to respond differentially to 2 stimuli. When the task is fully acquired, reward contingencies are reversed, requiring the subject to relearn the altered associations...
  73. ncbi Dissociable effects of dopamine and serotonin on reversal learning
    Hanneke E M den Ouden
    Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen 6500, The Netherlands Department of Psychology, New York University, New York, NY 10003, USA Electronic address
    Neuron 80:1090-100. 2013
    ..We studied the role of these neurotransmitters in probabilistic reversal learning in nearly 700 individuals as a function of two polymorphisms in the genes encoding the serotonin and ..
  74. pmc Association of attentional shift and reversal learning to functional deficits in geriatric depression
    Guy G Potter
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Int J Geriatr Psychiatry 27:1172-9. 2012
    The objective of this study is to examine the association between self-reported functional disability in depressed older adults and two types of executive function processes, attentional set shifting and reversal learning.
  75. ncbi Reversal learning as a neuropsychological indicator for the neuropathology of obsessive compulsive disorder? A behavioral study
    Gabriele Valerius
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, J5, D 68159 Mannheim, Germany
    J Neuropsychiatry Clin Neurosci 20:210-8. 2008
    ..Functional imaging studies suggest that reversal learning is affected by deficits in fronto-striatal brain areas and thus should be impaired in patients with OCD...
  76. ncbi The effects of binge MDMA on acquisition and reversal learning in a radial-arm maze task
    C Kay
    School of Psychology, Victoria University of Wellington, New Zealand
    Neurobiol Learn Mem 95:473-83. 2011
    ....
  77. pmc Working memory capacity predicts effects of methylphenidate on reversal learning
    Marieke E van der Schaaf
    Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neuropsychopharmacology 38:2011-8. 2013
    ..Moreover, they highlight the importance of taking into account both inter- and intra-individual differences in dopaminergic drug research...
  78. ncbi The effect of striatal dopamine depletion and the adenosine A2A antagonist KW-6002 on reversal learning in rats
    Martin O'Neill
    School of Psychology, University of St Andrews, KY16 9JU Scotland, UK
    Neurobiol Learn Mem 88:75-81. 2007
    ..in the number of trials to attain criterion performance in the reversal phases, indicating an impairment in reversal learning. KW-6002 (1mg/kg bidaily for 10 days) non-specifically increased the number of trials to criterion at all ..
  79. ncbi Impaired context reversal learning, but not cue reversal learning, in patients with amnestic mild cognitive impairment
    Einat Levy-Gigi
    Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA
    Neuropsychologia 49:3320-6. 2011
    It has been proposed that reversal learning is impaired following damage to the orbitofrontal and ventromedial frontal cortex (OFC/VMFC) and to the medial temporal lobe (MTL), including the hippocampal formation...
  80. ncbi Serial reversal learning and acute tryptophan depletion
    Geoffrey Van der Plasse
    Netherlands Institute for Neuroscience an Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA Amsterdam ZO, The Netherlands
    Behav Brain Res 186:23-31. 2008
    ..Recent data from primate studies moreover show that depletion of prefrontal 5-HT impairs reversal learning of visual stimuli [Clarke HF, Walker SC, Crofts HS, Dalley JW, Robbins TW, Roberts AC...
  81. ncbi Dopamine D2 receptors mediate reversal learning in male C57BL/6J mice
    Paul J Kruzich
    Oregon Health and Science University, Portland, Oregon 97239, USA
    Cogn Affect Behav Neurosci 6:86-90. 2006
    ..Dopamine is critical for directing goal-oriented behavior. We investigated dopamine D2 receptor involvement in reversal learning and reinforcement efficacy in mice lacking functional dopamine D2 receptors and their heterozygous and wild-..
  82. ncbi Delayed reversal learning and association with repetitive behavior in autism spectrum disorders
    Mikle South
    Department of Psychology, Brigham Young University, Provo, UT 84602, USA
    Autism Res 5:398-406. 2012
    ..and adolescents diagnosed with ASD and 29 age- and intelligence quotient-matched controls completed a reversal learning paradigm following partial reinforcement Pavlovian fear conditioning, using a surprising air puff as the ..
  83. ncbi Acute tryptophan depletion in healthy volunteers enhances punishment prediction but does not affect reward prediction
    Roshan Cools
    Department of Experimental Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 33:2291-9. 2008
    ..Furthermore, the finding highlights the importance of central 5-HT in resilience to adversity and may have implications for a variety of neuropsychiatric disorders including depression and anxiety...
  84. ncbi Spatial reversal learning is robust to total sleep deprivation
    Cathalijn H C Leenaars
    Dept of Sleep and Cognition, Netherlands Institute for Neurosciences, an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherland
    Behav Brain Res 230:40-7. 2012
    ..We first evaluated the effect of sleep deprivation on the acquisition of reversal learning. Performance on reversal learning after 12h of sleep deprivation (n=12) was compared to performance after ..
  85. ncbi Animal neuropsychology: validation of the Intra-Dimensional Extra-Dimensional set shifting task for mice
    Joseph P Garner
    Purdue University, Department of Animal Sciences, 125 South Russell Street, West Lafayette, IN 47907, USA
    Behav Brain Res 173:53-61. 2006
    ..Furthermore, overtrained mice were impaired on this extra-dimensional shift compared with controls, further validating the task. The advantages and disadvantages of the IDED task compared to high-throughput approaches are discussed...
  86. ncbi Double dissociation of social and environmental stimulation on spatial learning and reversal learning in rats
    Nicole C A Schrijver
    Institute of Animal Sciences, Physiology and Animal Husbandry, ETH Zurich, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland
    Behav Brain Res 152:307-14. 2004
    ..whether social and inanimate stimulation affect spatial memory formation and non-spatial discrimination reversal learning selectively...
  87. ncbi Distinct linear and non-linear trajectories of reward and punishment reversal learning during development: relevance for dopamine's role in adolescent decision making
    Marieke E van der Schaaf
    Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
    Dev Cogn Neurosci 1:578-90. 2011
    ..underlying the development of reward- and punishment-related processing across four age groups using a reversal learning task previously shown to depend on striatal dopamine...
  88. pmc Prenatal betamethasone exposure has sex specific effects in reversal learning and attention in juvenile baboons
    Jesse S Rodriguez
    Center for Pregnancy and Newborn Research, Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, 79229, USA
    Am J Obstet Gynecol 204:545.e1-10. 2011
    ..We investigated effects of 3 weekly courses of fetal betamethasone (βM) on motivation and cognition in juvenile baboon offspring utilizing the Cambridge Neuropsychological Test Automated Battery...
  89. pmc Frontal hyperconnectivity related to discounting and reversal learning in cocaine subjects
    Jazmin Camchong
    Department of Psychiatry, University of Minnesota, Minneapolis, 55414, USA
    Biol Psychiatry 69:1117-23. 2011
    ..In addition, we hypothesized that abnormalities would be associated with poor performance in delayed discounting and reversal learning tasks.
  90. ncbi Cortico-limbic-striatal contribution after response and reversal learning: a metabolic mapping study
    Camino Fidalgo
    Laboratory of Neuroscience, Faculty of Psychology, University of Oviedo, Plaza Feijoo, s n E 33003 Oviedo, Spain
    Brain Res 1368:143-50. 2011
    ..Particular subdivisions of the striatum have been shown to be critical for both motor-response learning and reversal learning. However, recent evidence suggests that different cortical and subcortical brain regions may be involved in ..
  91. ncbi Orbital prefrontal cortex mediates reversal learning and not attentional set shifting in the rat
    Kerry McAlonan
    School of Psychology, University of St Andrews, St Andrews KY16 9JU, Scotland, UK
    Behav Brain Res 146:97-103. 2003
    ..present investigation examined whether lesions to rat orbital prefrontal cortex would produce deficits in reversal learning in the absence of deficits in shifting attentional set, as seen in monkeys...
  92. ncbi Abnormal strategies during visual discrimination reversal learning in ephrin-A2(-/-) mice
    S Arnall
    School of Animal Biology, University of Western Australia, Crawley, WA 6009, Australia
    Behav Brain Res 209:109-13. 2010
    ..However, during reversal learning, when the rewarded stimulus was switched, the two genotypes exhibited differences in response strategies: ..
  93. ncbi Enhanced long-term depression and impaired reversal learning in phosphodiesterase 4B-knockout (PDE4B-/-) mice
    Kris Rutten
    CNS Discovery Research, Roche Palo Alto, Palo Alto, CA, USA
    Neuropharmacology 61:138-47. 2011
    ..On the behavioral level PDE4B(-/-) mice displayed impaired reversal learning in the Morris water maze compared to wild-type littermates, but no differences in acquisition and retention ..
  94. pmc Genetic dissection of behavioral flexibility: reversal learning in mice
    Rick E Laughlin
    Department of Psychology, University of California at Los Angeles, 90095 1563, USA
    Biol Psychiatry 69:1109-16. 2011
    ..Here, we investigate the genetic basis of individual differences in flexibility, measured using an operant reversal learning task.
  95. ncbi A comparison of Lewis and Fischer rat strains on autoshaping (sign-tracking), discrimination reversal learning and negative auto-maintenance
    David N Kearns
    Department of Psychology, American University, Washington DC 20016, USA
    Behav Brain Res 169:193-200. 2006
    ..The finding that LEW (as compared to F344 rats) more readily acquire autoshaping and perform more responses is consistent with research indicating that LEW rats behave more impulsively and more readily self-administer drugs of abuse...
  96. ncbi Effects of orbitofrontal, infralimbic and prelimbic cortical lesions on serial spatial reversal learning in the rat
    Vasileios Boulougouris
    Behavioural and Clinical Neuroscience Institute BCNI and the Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Behav Brain Res 179:219-28. 2007
    Recent evidence suggests that the neural correlates of reversal learning are localised to the orbitofrontal cortex whereas studies on the contribution of the medial prefrontal cortex to this capacity have produced equivocal results...
  97. ncbi Modeling psychotic and cognitive symptoms of affective disorders: Disrupted latent inhibition and reversal learning deficits in highly stress reactive mice
    A Knapman
    Research Group of Psychoneuroendocrinology, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Neurobiol Learn Mem 94:145-52. 2010
    ..Male mice from these three breeding lines were subjected to a reversal learning task and latent inhibition (Li) was assessed using a conditioned taste aversion paradigm...
  98. pmc Human reversal learning under conditions of certain versus uncertain outcomes
    Anna Maria D'Cruz
    Center for Cognitive Medicine, Chicago, IL 60612, USA
    Neuroimage 56:315-22. 2011
    b>Reversal learning tasks assess behavioral flexibility by requiring subjects to switch from one learned response choice to a different response choice when task contingencies change...
  99. ncbi Early discrimination reversal learning impairment and preserved spatial learning in a longitudinal study of Tg2576 APPsw mice
    Jia Min Zhuo
    College of Medicine, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    Neurobiol Aging 28:1248-57. 2007
    ..Older mice were also significantly impaired on reversal learning and on the intra- and extra-dimensional shift in attentional set-shifting...
  100. ncbi [Impairment effects of tail suspension stress on spatial memory and its reversal learning in mice]
    Xiao Qin Wang
    School of Physical Education, Yunnan Normal University, Kunming 650500, China
    Dongwuxue Yanjiu 32:428-34. 2011
    ..the effects of tail suspension stress (TSS) on spatial memory acquisition, consolidation, and its reversal learning in mice...
  101. pmc A comparison of discrimination and reversal learning for olfactory and visual stimuli in aged rats
    Andrea M Brushfield
    Department of Psychology, San Diego State University, CA 92120 4913, USA
    Behav Neurosci 122:54-62. 2008
    The present study investigated age-related differences in discrimination and reversal learning for olfactory and visual stimuli in 6-month and 24-month-old rats...

Research Grants62

  1. The Neurochemistry of Cognitive Therapy: Predicting Treatment Outcome with PET
    Jeffrey M Miller; Fiscal Year: 2013
    ..b>Reversal learning is a process in which subjects must establish and then reverse associations of specific stimuli with either ..
  2. Negative symptoms of schizophrenia: animal models
    Athina Markou; Fiscal Year: 2013
    ..variable-delay alternation task that assesses the working memory domain;and c) the cued-location reversal learning task that assesses cognitive flexibility, an aspect of the reasoning/problem solving domain...
  3. Alcohol and Development of the Prefrontal Cortex
    LEON GARLAND COLEMAN; Fiscal Year: 2011
    ..early postnatal and adolescent ethanol on adult behaviors, including tests of working memory, learning and reversal learning, prepulse inhibition, and anxiety;and 3...
  4. Kappa Opioid Receptor Imaging in Anorexia
    Alexander Neumeister; Fiscal Year: 2013
    ..Subjects will complete laboratory measures of food avoidance and a food-reward based reversal learning task...
  5. Safety Signal Learning in Monkeys: Cortical Regulation and its Development
    MICHAEL NMN DAVIS; Fiscal Year: 2013
    ..12 in safety signal learning and expression. As a positive control, we will also test these monkeys in reversal learning and reinforce devaluation that is known to be compromised by damage to one or more of these lesions...
  6. Cognitive Dysfunction after Chronic Cocaine
    Jane R Taylor; Fiscal Year: 2013
    ..Short-term COC exposure was sufficient to produce persistent and selective deficits in reversal learning and inhibition of pre-potent responding, effects indicative of selective OFC dysfunction, but did not alter ..
  7. Orbitofrontal Cortex Dysfunction After Chronic Ethanol Exposure
    Kimberly A Badanich; Fiscal Year: 2011
    ..attentional set-shifting by slowing acquisition rates and increasing the number of errors made during a reversal learning task (Bissonette et al, 2008)...
  8. UNC-CH NADIA Underage Drinking and Adult Brain Morphology in Rats
    Fulton T Crews; Fiscal Year: 2013
    ..These pathological changes were associated with functional deficits in reversal learning. This Research Component-7 of the NADIA consortium will extend these studies to determine the long-term ..
  9. Adult neurobiology following adolescent drinking
    Ryan Peter Vetreno; Fiscal Year: 2013
    ..to reduce forebrain volume and cholinergic cell populations in the nucleus basalis that was associated with reversal learning impairment on the Morris Water maze...
  10. Psychological and Cognitive Mechanisms of Sexual Compulsivity and HIV Risk
    Michael H Miner; Fiscal Year: 2013
    ..control through the use of three cognitive tasks: the Stroop task that measures conflict monitoring, the Reversal learning task that measures inhibitory control, and the Delayed dis- counting task that measures the tendency to ..
  11. Reversal Learning in Pediatric Bipolar Disorder
    DANIEL DICKSTEIN; Fiscal Year: 2009
    ..Emerging data shows that BPD children are impaired in reversal learning. This process requires behavioral adaptation to changing stimulus-reward contingencies and engages the ..
  12. Bio-Behavioral Markers of Bipolar Conversion
    Daniel P Dickstein; Fiscal Year: 2013
    ..We will collect behavioral task (reversal learning, face processing), multi-modal magnetic resonance imaging (MRI;including structural MRI, functional MRI, DTI,..
  13. The aging brain: Imaging genetics of brain structure and function
    Ira Driscoll; Fiscal Year: 2013
    ..gene variants and cognitive tasks allowing for cross-species comparisons and probing either frontal (reversal learning, elemental discriminations) or medial temporal (virtual water maze, transverse patterning) lobe function;(2) ..
  14. Identifying cognitive markers of late-life suicide
    Katalin Szanto; Fiscal Year: 2013
    ..in a large- enough sample to test hypotheses that impairments in decision-making, affective processing, reversal learning, and social cognition are specifically associated with suicide attempts in depressed elders...
  15. 1/5-Cognitive Neuroscience Task Reliability &Clinical Applications Consortium
    Deanna M Barch; Fiscal Year: 2013
    ..measures of WM capacity, positive and negative reinforcement learning (both implicit and explicit) and reversal learning, and then apply them together with previously validated measures...
  16. Endocannabinoids and the modulation of expectation
    JOSEPH FRANCOIS RENE CHEER; Fiscal Year: 2013
    ..Given the ability of cannabinoids to impair reversal learning with specific OFC correlates12, we will investigate the role of endocannabinoid signaling in the OFC in ..
  17. 2/5-Cognitive Neuroscience Task Reliability &Clinical Application Consortium
    Cameron S Carter; Fiscal Year: 2013
    ..measures of WM capacity, positive and negative reinforcement learning (both implicit and explicit) and reversal learning, and then apply them together with previously validated measures...
  18. Neurophysiology underlying neural representations of value
    C Daniel Salzman; Fiscal Year: 2013
    ..In Aim 1, we will study the role of the amygdala and anterior cingulate cortex in a reversal learning procedure, whereby the previously learned associations of two stimuli reverse (or switch)...
  19. Neural mechanisms of associative learning from negative reward prediction errors
    Masaaki Ogawa; Fiscal Year: 2010
    ..In accord with this hypothesis, chronic cocaine users have demonstrated behavioral deficits in reversal learning tasks, which are exquisitely sensitive to manipulations that disrupt OFC function...
  20. Role of the medial septum in perseverative behaviors
    Kevin C H Pang; Fiscal Year: 2012
    ..The proposed studies will test this hypothesis utilizing a novel GABAergic toxin and focusing on reversal learning. Aims 1 and 2 will characterize the effects of this new GABAergic toxin in the medial septum using ..
  21. Genetic Influences on Inhibitory Control and Cocaine Sensitivity
    J David Jentsch; Fiscal Year: 2013
    ..from the panel that will already have been studied for their ability to inhibit impulsive responding in a reversal learning test;in doing so, we will be ble to measure the genetic correlation between these traits...
  22. TEST OF TAURINE AS AN ESSENTIAL NUTRIENT
    John Sturman; Fiscal Year: 1993
    ..of learning and memory, including tests of visual recognition memory in young infants and, in older animals, reversal learning, delayed alternation and delayed matching-to-sample tests...
  23. COGFLEX: Pilot Translational Intervention for Pediatric Bipolar Disorder
    Daniel P Dickstein; Fiscal Year: 2013
    ..This includes my own work showing that BD youths have behavioral and functional MRI neural alterations in reversal learning. THE PRIMARY OBJECTIVE of this R21/R33 Translational Novel Interventions grant application is to accelerate ..
  24. Cognitive Regulation and Reversal of Fear: Physiological and Neural Mechanisms
    Vincent D Costa; Fiscal Year: 2010
    ..Additional hypotheses address whether increases in dental fear impair or enhance fearful responses during reversal learning.
  25. Cognitive Function in Alcohol Dependence and Protracted Withdrawal
    Loren H Parsons; Fiscal Year: 2013
    ..indexed using the Delay Discount Test, and cognitive flexibility will be assessed using an operant spatial reversal learning task...
  26. Flexibility, prefrontal function, and changes with normal aging
    JOSEPH FRANCOIS RENE CHEER; Fiscal Year: 2011
    ..These deficits are evident in tasks that test reversal learning and set-shifting...
  27. A Multi-Component Approach to Extinction in Pavlovian Learning
    ANDREW DELAMATER; Fiscal Year: 2013
    ..e., spontaneous recovery, reinstatement, renewal, and reversal learning)...
  28. PCB Neurotoxicity: Effects on Cerebellar Development
    Lisa Opanashuk; Fiscal Year: 2004
    ..defective locomotor activity, altered eyeblink conditioning, and impaired delayed spatial alternation and reversal learning. The nature of these alterations likely reflects PCB-induced disruption of cerebellar output...
  29. Cognitive Effects of 5-HT and SSRIs in Rat Prefrontal Cortex
    David A Morilak; Fiscal Year: 2010
    ..Two weeks of chronic stress induced a selective deficit in reversal learning on the AST, which has been linked to orbitofrontal cortex, and which may be modulated specifically by 5-HT...
  30. CONTEXTUAL CONTROL OF OPIATE EFFECTS
    TORBJORN JARBE; Fiscal Year: 1999
    ..to be used in this analysis include overshadowing, blocking, latent inhibition or pre- exposure effect, reversal learning, extinction, as well as random reinforcement training...
  31. NMDA RECEPTOR AND BEHAVIORAL TOXICITY OF LEAD
    Deborah Cory Slechta; Fiscal Year: 2002
    ..sensitization; 2) that MESO system disruptions mediate Pb-induced changes in FI performance and spatial/reversal learning, and that 3) Pb will attenuate MK-801-induced alterations in evoked DA overflow...
  32. BEHAVIORAL EFFECTS OF EARLY ETHANOL AND MK801 EXPOSURE
    Jennifer Thomas; Fiscal Year: 1999
    ..performance is examined with two behavioral tasks: open field activity and serial spatial discrimination reversal learning. These two tasks are sensitive to early alcohol exposure and are believed to rely on the functional ..
  33. TESTING FASD THERAPEUTIC AGENTS: NEONATAL RODENT MODELS
    Charles Goodlett; Fiscal Year: 2005
    ..exposure on PD 7 in C57BL/6 mice will damage hippocampal circuits necessary for eyeblink discrimination reversal learning, and that the candidate agent will protect against this hippocampal damage...
  34. Behavioral Momentum & Flexibility in Mental Retardation
    WILLIAM DUBE; Fiscal Year: 2004
    ..g., in reversal learning)...
  35. Vervet Monkey Model for Methamphetamine-Induced Deficits in Response Inhibition
    Buyean Lee; Fiscal Year: 2005
    ..It can be measured quantitatively by cognitive tasks, such as the reversal learning task, which requires a learned response to be inhibited in favor of an alternative one...
  36. Incentive learning and decision making in the aging brain
    GREGORY R SAMANEZ LARKIN; Fiscal Year: 2010
    ..life span, (2) examine whether older adults show the same valence asymmetry in more cognitively demanding reversal learning, and (3) examine whether older adults differ from younger adults both in rational risky decision-making and ..
  37. Aging, Serotonin and Reversal Learning
    MICHAEL RAGOZZINO; Fiscal Year: 2008
    ..whether administration of the selective 5-HT4 agonist, RS 67333, in young adult and aged rats affects reversal learning in a two-choice place discrimination...
  38. Striatal Acetylcholine and Behavioral Flexibility
    MICHAEL RAGOZZINO; Fiscal Year: 2005
    ..dynamic changes in acetylcholine output in the dorsomedial and dorsolateral striatum during acquisition and reversal learning of a visual cue discrimination, using in vivo microdialysis with high pressure liquid chromatography...
  39. Linking Affect to Action: Critical Contributions of the Orbitofrontal Cortex
    Geoffrey Schoenbaum; Fiscal Year: 2006
    ..The participation of minorities and women has been emphasized at each level (organizers, speakers, students). Thus the conference will address important scientific, social, and educational issues. [unreadable] [unreadable] [unreadable]..
  40. Errors and Expectancies in OFC and VTA and their Roles in Associative Learning
    GEOFFREY M SCHOENBAUM; Fiscal Year: 2010
    ..This proposal will test this hypothesis, using inactivation and single-unit recording to ask how OFC is involved learning and in the calculation of prediction errors in dopaminergic VTA neurons during Pavlovian blocking. ..
  41. Neurobiology of Spatial Reversal Learning
    Deborah Watson; Fiscal Year: 2008
    ..such as autism spectrum disorder (ASD) and fetal alcohol spectrum disorder (FASD) in which impaired reversal learning is a prominent feature...
  42. Mapping the Anatomy of Decision Making
    Lesley Fellows; Fiscal Year: 2004
    ..This approach has the potential to provide insights into the basis for a wide range of pathological human behavior. ..
  43. RSA Lecture Series
    Jennifer Thomas; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  44. COGNITION AND ESTROGEN IN MIDDLE-AGED FEMALE MONKEYS
    Mary Lou Voytko; Fiscal Year: 2003
    ..The findings from these novel experiments in middle-aged monkeys will significantly advance our understanding of the effects of different ovarian hormone therapies on cognitive and neurobiological profiles of primates. ..
  45. Cognition and Estrogen in Menopause:A Monkey Model
    Mary Lou Voytko; Fiscal Year: 2006
    ..The findings from these novel experiments in middle-aged monkeys will significantly advance our understanding of the effects of ovarian hormone therapy on cognitive and neurobiological profiles of primates. ..
  46. Marine Toxin Impacts on Neurobehavioral Function
    Edward Levin; Fiscal Year: 2003
    ..The forum will provide an opportunity for methodological and theoretical issues to be integrated in the context of each talk as well as in a discussion session at the end of the symposium. ..
  47. The Cognitive Neuroscience of Human Category Learning
    F Ashby; Fiscal Year: 2009
    ..g., teaching radiologists to find tumors in x-rays). ..
  48. Age-Related Odor Memory Impairment in a Rodent Model
    Paul E Gilbert; Fiscal Year: 2010
    ..Specific aim 1 will investigate age- related differences in discrimination and reversal learning for olfactory and visual stimuli...
  49. Neurocognitive consequences of adolescent drug use
    MARK FILLMORE; Fiscal Year: 2007
    ....
  50. ETHANOL EFFECTS ON NEUROTRANSMISSION
    Fulton Crews; Fiscal Year: 2009
    ..abstract_text> ..
  51. Cognitive-Behavioral Therapy for Pathological Gambling
    Jon Grant; Fiscal Year: 2008
    ..This award would provide me with the necessary background for further studies in the treatment of pathological gambling and the training for an independent patient-oriented research career. ..
  52. Cognitive Processes in Cocaine and Polydrug Abuse
    MARK FILLMORE; Fiscal Year: 2005
    ....
  53. Adolescence: A Sensitive Period for Nicotine Addiction
    Edward Levin; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  54. Understanding Neurodevelopment in Macaques with Different Rearing Experiences
    Mar Sanchez; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  55. Behavioral Model of Contextual Attention in the Monkey
    J Jentsch; Fiscal Year: 2003
    ..The development of such an approach to modeling contextual aspects of attention, in particular, in animals should be a major advance linking pre-clinical psychopharmacological studies and treatment-based research for schizophrenia. ..
  56. Neural mechanisms of risk aversion
    Joshua Brown; Fiscal Year: 2007
    ..Once we know how certain parts of the brain avoid risky behavior, then we will figure out how to help these parts of the brain to keep people from taking drugs. [unreadable] [unreadable] [unreadable]..
  57. Mechanisms of neurotrophin-improved cognition in aging
    ANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2007
    ..abstract_text> ..
  58. A1/A2A Receptors and Caffeine Psychostimulation
    Jiang Fan Chen; Fiscal Year: 2009
    ..abstract_text> ..