memory

Summary

Summary: Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.

Top Publications

  1. ncbi An integrative theory of prefrontal cortex function
    E K Miller
    Center for Learning and Memory, RIKEN MIT Neuroscience Research Center and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Neurosci 24:167-202. 2001
  2. ncbi A specific amyloid-beta protein assembly in the brain impairs memory
    Sylvain Lesne
    Department of Neurology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nature 440:352-7. 2006
  3. ncbi The molecular biology of memory storage: a dialogue between genes and synapses
    E R Kandel
    Howard Hughes Medical Institute, Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Science 294:1030-8. 2001
  4. ncbi Working memory: looking back and looking forward
    Alan Baddeley
    Department of Psychology, University of York, York YO10 5DD, UK
    Nat Rev Neurosci 4:829-39. 2003
  5. pmc HDAC2 negatively regulates memory formation and synaptic plasticity
    Ji Song Guan
    Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences
    Nature 459:55-60. 2009
  6. ncbi EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis
    W Klimesch
    Department of Physiological Psychology, Institute of Psychology, University of Salzburg, Hellbrunnerstr 34, A 5020, Salzburg, Austria
    Brain Res Brain Res Rev 29:169-95. 1999
  7. doi The common neural basis of autobiographical memory, prospection, navigation, theory of mind, and the default mode: a quantitative meta-analysis
    R Nathan Spreng
    Rotman Research Institute, Baycrest Centre, Toronto, Canada
    J Cogn Neurosci 21:489-510. 2009
  8. pmc Long-term potentiation depends on release of D-serine from astrocytes
    Christian Henneberger
    UCL Institute of Neurology, University College London, London WC1N 3BG, UK
    Nature 463:232-6. 2010
  9. doi Altered histone acetylation is associated with age-dependent memory impairment in mice
    Shahaf Peleg
    Laboratory for Aging and Cognitive Diseases, European Neuroscience Institute, Grisebach Str 5, D 37077 Goettingen, Germany
    Science 328:753-6. 2010
  10. ncbi A synaptic model of memory: long-term potentiation in the hippocampus
    T V Bliss
    Division of Neurophysiology and Neuropharmacology, National Institute of Medical Research, Mill Hill, London, UK
    Nature 361:31-9. 1993

Research Grants

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
  2. James D Bryers; Fiscal Year: 2016
  3. Role of NGF in inflammatory and proliferative cascades of psoriatic disease
    Siba P Raychaudhuri; Fiscal Year: 2012
  4. Importance of antigen specific immunoglobulin responses in controlling SIV/SHIV i
    Bapi Pahar; Fiscal Year: 2010
  5. Tyrosine Availability Influences Mesocortico-Limbic Catecholamines
    GEORGE EUGENE JASKIW; Fiscal Year: 2012
  6. Charles W Wilkinson; Fiscal Year: 2016
  7. Regulation of B Cell Function by Membrane-Cytoskeletal Remodeling
    Neetu Gupta; Fiscal Year: 2012
  8. Statin modulation of immunotherapy for Alzheimer disease
    Jun Tan; Fiscal Year: 2012
  9. Schahram Akbarian; Fiscal Year: 2014
  10. Charlotte Cunningham-Rundles; Fiscal Year: 2015

Detail Information

Publications424 found, 100 shown here

  1. ncbi An integrative theory of prefrontal cortex function
    E K Miller
    Center for Learning and Memory, RIKEN MIT Neuroscience Research Center and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Neurosci 24:167-202. 2001
    ..We review neurophysiological, neurobiological, neuroimaging, and computational studies that support this theory and discuss its implications as well as further issues to be addressed..
  2. ncbi A specific amyloid-beta protein assembly in the brain impairs memory
    Sylvain Lesne
    Department of Neurology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nature 440:352-7. 2006
    b>Memory function often declines with age, and is believed to deteriorate initially because of changes in synaptic function rather than loss of neurons. Some individuals then go on to develop Alzheimer's disease with neurodegeneration...
  3. ncbi The molecular biology of memory storage: a dialogue between genes and synapses
    E R Kandel
    Howard Hughes Medical Institute, Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Science 294:1030-8. 2001
    ..For me, learning and memory have proven to be endlessly fascinating mental processes because they address one of the fundamental features of ..
  4. ncbi Working memory: looking back and looking forward
    Alan Baddeley
    Department of Psychology, University of York, York YO10 5DD, UK
    Nat Rev Neurosci 4:829-39. 2003
  5. pmc HDAC2 negatively regulates memory formation and synaptic plasticity
    Ji Song Guan
    Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences
    Nature 459:55-60. 2009
    Chromatin modifications, especially histone-tail acetylation, have been implicated in memory formation...
  6. ncbi EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis
    W Klimesch
    Department of Physiological Psychology, Institute of Psychology, University of Salzburg, Hellbrunnerstr 34, A 5020, Salzburg, Austria
    Brain Res Brain Res Rev 29:169-95. 1999
    Evidence is presented that EEG oscillations in the alpha and theta band reflect cognitive and memory performance in particular...
  7. doi The common neural basis of autobiographical memory, prospection, navigation, theory of mind, and the default mode: a quantitative meta-analysis
    R Nathan Spreng
    Rotman Research Institute, Baycrest Centre, Toronto, Canada
    J Cogn Neurosci 21:489-510. 2009
    ..amp; Maguire, E. A. Deconstructing episodic memory with construction. Trends in Cognitive Sciences, 11, 299-306, 2007]...
  8. pmc Long-term potentiation depends on release of D-serine from astrocytes
    Christian Henneberger
    UCL Institute of Neurology, University College London, London WC1N 3BG, UK
    Nature 463:232-6. 2010
    Long-term potentiation (LTP) of synaptic transmission provides an experimental model for studying mechanisms of memory. The classical form of LTP relies on N-methyl-D-aspartate receptors (NMDARs), and it has been shown that astroglia can ..
  9. doi Altered histone acetylation is associated with age-dependent memory impairment in mice
    Shahaf Peleg
    Laboratory for Aging and Cognitive Diseases, European Neuroscience Institute, Grisebach Str 5, D 37077 Goettingen, Germany
    Science 328:753-6. 2010
    ..The mechanisms underlying age-associated memory impairment are, however, not understood...
  10. ncbi A synaptic model of memory: long-term potentiation in the hippocampus
    T V Bliss
    Division of Neurophysiology and Neuropharmacology, National Institute of Medical Research, Mill Hill, London, UK
    Nature 361:31-9. 1993
    ..in the hippocampus is the primary experimental model for investigating the synaptic basis of learning and memory in vertebrates...
  11. ncbi The medial temporal lobe
    Larry R Squire
    Veterans Affairs Healthcare System, San Diego, California 92161, USA
    Annu Rev Neurosci 27:279-306. 2004
    The medial temporal lobe includes a system of anatomically related structures that are essential for declarative memory (conscious memory for facts and events)...
  12. ncbi Learning induces long-term potentiation in the hippocampus
    Jonathan R Whitlock
    Howard Hughes Medical Institute, Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 313:1093-7. 2006
    ..These efforts have been motivated by the belief that similar synaptic modifications occur during memory formation, but it has never been shown that learning actually induces LTP in CA1...
  13. pmc A novel pathway regulates memory and plasticity via SIRT1 and miR-134
    Jun Gao
    Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 466:1105-9. 2010
    ..We report that SIRT1 modulates synaptic plasticity and memory formation via a microRNA-mediated mechanism...
  14. pmc Structural basis of long-term potentiation in single dendritic spines
    Masanori Matsuzaki
    Department of Cell Physiology, National Institute for Physiological Sciences and The Graduate University of Advanced Studies Sokendai, Myodaiji, Okazaki 444 8787, Japan
    Nature 429:761-6. 2004
    ..undergo activity-dependent structural remodelling that has been proposed to be a cellular basis of learning and memory. How structural remodelling supports synaptic plasticity, such as long-term potentiation, and whether such ..
  15. ncbi Sleep function and synaptic homeostasis
    Giulio Tononi
    Department of Psychiatry, University of Wisconsin, 6001 Research Park Blvd, Madison, WI 53719, USA
    Sleep Med Rev 10:49-62. 2006
    ..that is energetically sustainable, makes efficient use of gray matter space, and is beneficial for learning and memory. Thus, sleep is the price we have to pay for plasticity, and its goal is the homeostatic regulation of the total ..
  16. doi The memory function of sleep
    Susanne Diekelmann
    University of Lubeck, Department of Neuroendocrinology, 23538 Lubeck, Germany
    Nat Rev Neurosci 11:114-26. 2010
    Sleep has been identified as a state that optimizes the consolidation of newly acquired information in memory, depending on the specific conditions of learning and the timing of sleep...
  17. pmc The neurobiology of semantic memory
    Jeffrey R Binder
    Department of Neurology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Trends Cogn Sci 15:527-36. 2011
    Semantic memory includes all acquired knowledge about the world and is the basis for nearly all human activity, yet its neurobiological foundation is only now becoming clear...
  18. pmc Improving fluid intelligence with training on working memory
    Susanne M Jaeggi
    Department of Psychology, University of Michigan, East Hall, 530 Church Street, Ann Arbor, MI 48109 1043, USA
    Proc Natl Acad Sci U S A 105:6829-33. 2008
    ..Here, we present evidence for transfer from training on a demanding working memory task to measures of Gf...
  19. pmc The future of memory: remembering, imagining, and the brain
    Daniel L Schacter
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Neuron 76:677-94. 2012
    During the past few years, there has been a dramatic increase in research examining the role of memory in imagination and future thinking...
  20. pmc Requirement for hippocampal CA3 NMDA receptors in associative memory recall
    Kazu Nakazawa
    Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 297:211-8. 2002
    ..ability to retrieve complete memories on the basis of incomplete sets of cues, is a crucial function of biological memory systems...
  21. ncbi The amygdala modulates the consolidation of memories of emotionally arousing experiences
    James L McGaugh
    Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine 92697 3800
    Annu Rev Neurosci 27:1-28. 2004
    ..and drugs, as well as selective lesions of specific amygdala nuclei, indicates that (a) the amygdala mediates the memory-modulating effects of adrenal stress hormones and several classes of neurotransmitters; (b) the effects are ..
  22. ncbi Spatiotemporal rescue of memory dysfunction in Drosophila
    Sean E McGuire
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 302:1765-8. 2003
    ..gene expression targeting (TARGET) in Drosophila and show the simultaneous spatial and temporal rescue of a memory defect...
  23. pmc Where is the semantic system? A critical review and meta-analysis of 120 functional neuroimaging studies
    Jeffrey R Binder
    Language Imaging Laboratory, Department of Neurology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Cereb Cortex 19:2767-96. 2009
    Semantic memory refers to knowledge about people, objects, actions, relations, self, and culture acquired through experience...
  24. ncbi Reverse replay of behavioural sequences in hippocampal place cells during the awake state
    David J Foster
    Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 46 5223, Cambridge, Massachusetts 02139, USA
    Nature 440:680-3. 2006
    The hippocampus has long been known to be involved in spatial navigational learning in rodents, and in memory for events in rodents, primates and humans...
  25. ncbi Neural activity predicts individual differences in visual working memory capacity
    Edward K Vogel
    Department of Psychology, University of Oregon, Eugene, Oregon 97403 1227, USA
    Nature 428:748-51. 2004
    Contrary to our rich phenomenological visual experience, our visual short-term memory system can maintain representations of only three to four objects at any given moment...
  26. ncbi Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network
    Thomas J McHugh
    Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 317:94-9. 2007
    ..These results provide evidence that NMDA receptors in the granule cells of the dentate gyrus play a crucial role in the process of pattern separation...
  27. ncbi Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval
    K Nader
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York 10003, USA
    Nature 406:722-6. 2000
    ..The lateral and basal nuclei of the amygdala (LBA) are believed to be a site of memory storage in fear learning...
  28. pmc Decoding reveals the contents of visual working memory in early visual areas
    Stephenie A Harrison
    Psychology Department and Vanderbilt Vision Research Center, Vanderbilt University, Nashville, Tennessee 37240, USA
    Nature 458:632-5. 2009
    Visual working memory provides an essential link between perception and higher cognitive functions, allowing for the active maintenance of information about stimuli no longer in view...
  29. pmc mTOR signaling: at the crossroads of plasticity, memory and disease
    Charles A Hoeffer
    Center for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA
    Trends Neurosci 33:67-75. 2010
    ..establishing long-lasting synaptic changes that are the basis for higher order brain function, including long-term memory. Finally, perturbation of the mTOR signaling cascade appears to be a common pathophysiological feature of human ..
  30. pmc Traces of Drosophila memory
    Ronald L Davis
    Department of Neuroscience, The Scripps Research Institute Florida, Jupiter, FL 33410, USA
    Neuron 70:8-19. 2011
    Studies using functional cellular imaging of living flies have identified six memory traces that form in the olfactory nervous system after conditioning with odors...
  31. ncbi Capacity limit of visual short-term memory in human posterior parietal cortex
    J Jay Todd
    Vanderbilt Vision Research Center, Department of Psychology, Vanderbilt University, 530 Wilson Hall, Nashville, Tennessee 37203, USA
    Nature 428:751-4. 2004
    ..These mental representations are stored in visual short-term memory (VSTM)...
  32. ncbi Polychronization: computation with spikes
    Eugene M Izhikevich
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Neural Comput 18:245-82. 2006
    ..of coexisting polychronous groups far exceeds the number of neurons in the network, resulting in an unprecedented memory capacity of the system...
  33. pmc Brain connectivity related to working memory performance
    Michelle Hampson
    Department of Diagnostic Radiology, Yale School of Medicine, New Haven, Connecticut 06520 8042, USA
    J Neurosci 26:13338-43. 2006
    ..This study investigated the functional connectivity between the PCC and MFG/vACC during a working memory task and at rest by examining temporal correlations in magnetic resonance signal levels between the regions...
  34. ncbi Practice with sleep makes perfect: sleep-dependent motor skill learning
    Matthew P Walker
    Laboratory of Neurophysiology, Department of Psychiatry, Harvard Medical School, 74 Fenwood Road, Boston, Massachusetts 02115, USA
    Neuron 35:205-11. 2002
    ..This finding of sleep-dependent motor skill improvement may have important implications for the efficient learning of all skilled actions in humans...
  35. ncbi Boosting slow oscillations during sleep potentiates memory
    Lisa Marshall
    University of Lubeck, Department of Neuroendocrinology, Haus 23a, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Nature 444:610-3. 2006
    ..band that normally predominates during rapid-eye-movement sleep--decreased slow oscillations and left declarative memory unchanged...
  36. pmc The parietal cortex and episodic memory: an attentional account
    Roberto Cabeza
    Center for Cognitive Neuroscience, Duke University, B203 LSRC Building, Durham, North Carolina 27708, USA
    Nat Rev Neurosci 9:613-25. 2008
    The contribution of the parietal cortex to episodic memory is a fascinating scientific puzzle...
  37. doi Cerebrospinal fluid markers for differential dementia diagnosis in a large memory clinic cohort
    N S M Schoonenboom
    Departments of Neurology, VU University Medical Center, Alzheimer Center, Amsterdam, The Netherlands
    Neurology 78:47-54. 2012
    ..To determine how amyloid β 42 (Aβ42), total tau (t-tau), and phosphorylated tau (p-tau) levels in CSF behave in a large cohort of patients with different types of dementia...
  38. pmc Exercise training increases size of hippocampus and improves memory
    Kirk I Erickson
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Proc Natl Acad Sci U S A 108:3017-22. 2011
    The hippocampus shrinks in late adulthood, leading to impaired memory and increased risk for dementia...
  39. pmc Phantom percepts: tinnitus and pain as persisting aversive memory networks
    Dirk De Ridder
    Tinnitus Research Initiative, Brain Research Center Antwerp for Innovative and Interdisciplinary Neuromodulation, and Department of Neurosurgery, University Hospital Antwerp, 2650 Edegem, Belgium
    Proc Natl Acad Sci U S A 108:8075-80. 2011
    ..b>Memory mechanisms play a role in the persistence of the awareness of the phantom percept, as well as in the reinforcement ..
  40. ncbi From sensation to cognition
    M M Mesulam
    Department of Neurology, Northwestern University Medical School, Chicago 60611, USA
    Brain 121:1013-52. 1998
    ..and the frontal eye fields; the language network on epicentres in Wernicke's and Broca's areas; the explicit memory/emotion network on epicentres in the hippocampal-entorhinal complex and the amygdala; the face-object recognition ..
  41. pmc Effects of cognitive training interventions with older adults: a randomized controlled trial
    Karlene Ball
    Department of Psychology, University of Alabama at Birmingham, 35294 2100, USA
    JAMA 288:2271-81. 2002
    ..However, few studies have addressed whether improving cognitive functions might have short- or long-term effects on activities related to living independently...
  42. ncbi Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory
    Randy L Buckner
    Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63105, USA
    J Neurosci 25:7709-17. 2005
    ..magnetic resonance imaging studies further revealed that these cortical regions are active during successful memory retrieval in young adults...
  43. ncbi Neural mechanisms of addiction: the role of reward-related learning and memory
    Steven E Hyman
    Office of the Provost, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Neurosci 29:565-98. 2006
    ..Here we review progress in identifying candidate mechanisms of addiction...
  44. ncbi Contextual cueing: implicit learning and memory of visual context guides spatial attention
    M M Chun
    Department of Psychology, Yale University, New Haven, CT 06520 8205, USA
    Cogn Psychol 36:28-71. 1998
    ..This study demonstrates that a robust memory for visual context exists to guide spatial attention...
  45. pmc The functional neuroanatomy of autobiographical memory: a meta-analysis
    Eva Svoboda
    Rotman Research Institute, Baycrest, 3560 Bathurst Street, Toronto, Ontario M6A 2E1, Canada
    Neuropsychologia 44:2189-208. 2006
    Autobiographical memory (AM) entails a complex set of operations, including episodic memory, self-reflection, emotion, visual imagery, attention, executive functions, and semantic processes...
  46. pmc Patients with hippocampal amnesia cannot imagine new experiences
    Demis Hassabis
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, United Kingdom
    Proc Natl Acad Sci U S A 104:1726-31. 2007
    ..Given how closely imagined experiences match episodic memories, the absence of this function mediated by the hippocampus, may also fundamentally affect the ability to vividly re-experience the past...
  47. pmc Using imagination to understand the neural basis of episodic memory
    Demis Hassabis
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 27:14365-74. 2007
    Functional MRI (fMRI) studies investigating the neural basis of episodic memory recall, and the related task of thinking about plausible personal future events, have revealed a consistent network of associated brain regions...
  48. doi MicroRNA loss enhances learning and memory in mice
    Witold Konopka
    Molecular Biology of the Cell I, German Cancer Research Center, D 69120 Heidelberg, Germany
    J Neurosci 30:14835-42. 2010
    ..Compatible with rather long half-life of miRNAs in hippocampal neurons, we observed an enhancement of memory strength of mutant mice 12 weeks after the Dicer1 gene mutation, before the onset of neurodegenerative process...
  49. doi Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
    Itaru Imayoshi
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan
    Nat Neurosci 11:1153-61. 2008
    ..of increases in the granule cell number in the dentate gyrus and impairment of behaviors in contextual and spatial memory, which are known to depend on hippocampus...
  50. ncbi N-back working memory paradigm: a meta-analysis of normative functional neuroimaging studies
    Adrian M Owen
    MRC Cognition and Brain Sciences Unit, Cambridge, United Kingdom
    Hum Brain Mapp 25:46-59. 2005
    One of the most popular experimental paradigms for functional neuroimaging studies of working memory has been the n-back task, in which subjects are asked to monitor the identity or location of a series of verbal or nonverbal stimuli and ..
  51. pmc Morris water maze: procedures for assessing spatial and related forms of learning and memory
    Charles V Vorhees
    Division of Neurology MLC 7044, Cincinnati Children s Research Foundation and Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Nat Protoc 1:848-58. 2006
    ..Spatial learning is assessed across repeated trials and reference memory is determined by preference for the platform area when the platform is absent...
  52. pmc Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
    Ganesh M Shankar
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Med 14:837-42. 2008
    ..Soluble Abeta from Alzheimer's disease brain also disrupted the memory of a learned behavior in normal rats. These various effects were specifically attributable to Abeta dimers...
  53. ncbi Learning and memory functions of the Basal Ganglia
    Mark G Packard
    Department of Psychology, Yale University, New Haven, Connecticut 06520, USA
    Annu Rev Neurosci 25:563-93. 2002
    ..Extensive evidence now indicates a role for the basal ganglia, in particular the dorsal striatum, in learning and memory. One prominent hypothesis is that this brain region mediates a form of learning in which stimulus-response (S-R) ..
  54. pmc The role of acetylcholine in learning and memory
    Michael E Hasselmo
    Center for Memory and Brain, Boston University, 2 Cummington Street, Boston, MA 02215, USA
    Curr Opin Neurobiol 16:710-5. 2006
    ..These effects might enhance different types of encoding in different cortical structures. In particular, the effects in entorhinal and perirhinal cortex and hippocampus might be important for encoding new episodic memories...
  55. ncbi Recovery of learning and memory is associated with chromatin remodelling
    Andre Fischer
    Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139, USA
    Nature 447:178-82. 2007
    Neurodegenerative diseases of the central nervous system are often associated with impaired learning and memory, eventually leading to dementia...
  56. pmc Memory, navigation and theta rhythm in the hippocampal-entorhinal system
    Gyorgy Buzsaki
    NYU Neuroscience Institute and Center for Neural Sciences, New York University, New York, New York, USA
    Nat Neurosci 16:130-8. 2013
    ..Here we propose that mechanisms of memory and planning have evolved from mechanisms of navigation in the physical world and hypothesize that the neuronal ..
  57. ncbi Cognitive neuroscience of emotional memory
    Kevin S LaBar
    Center for Cognitive Neuroscience, Duke University, Durham, North Carolina 27708, USA
    Nat Rev Neurosci 7:54-64. 2006
    Emotional events often attain a privileged status in memory. Cognitive neuroscientists have begun to elucidate the psychological and neural mechanisms underlying emotional retention advantages in the human brain...
  58. ncbi Episodic memory: from mind to brain
    Endel Tulving
    Rotman Research Institute of Baycrest Centre, Toronto, Canada
    Annu Rev Psychol 53:1-25. 2002
    Episodic memory is a neurocognitive (brain/mind) system, uniquely different from other memory systems, that enables human beings to remember past experiences. The notion of episodic memory was first proposed some 30 years ago...
  59. ncbi Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis
    Jacob Raber
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, 97239, USA
    Radiat Res 162:39-47. 2004
    ..Compared to controls, X-irradiated mice showed hippocampal-dependent spatial learning and memory impairments in the Barnes maze but not the Morris water maze...
  60. pmc Theta rhythms coordinate hippocampal-prefrontal interactions in a spatial memory task
    Matthew W Jones
    The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    PLoS Biol 3:e402. 2005
    ..that correlated firing in the two structures is selectively enhanced during behavior that recruits spatial working memory, allowing the integration of hippocampal spatial information into a broader, decision-making network...
  61. ncbi Dendritic protein synthesis, synaptic plasticity, and memory
    Michael A Sutton
    Division of Biology 114 96, California Institute of Technology, Howard Hughes Medical Institute, Pasadena, CA 91125, USA
    Cell 127:49-58. 2006
    ..Here, we review the experimental support for this idea and highlight some of the key questions outstanding in this area...
  62. doi Amygdala inhibitory circuits and the control of fear memory
    Ingrid Ehrlich
    Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland
    Neuron 62:757-71. 2009
    ..is a powerful behavioral paradigm that is widely used to study the neuronal substrates of learning and memory. Previous studies have clearly identified the amygdala as a key brain structure for acquisition and storage of ..
  63. pmc Hippocampal replay in the awake state: a potential substrate for memory consolidation and retrieval
    Margaret F Carr
    Department of Physiology, University of California, San Francisco, San Francisco, California, USA
    Nat Neurosci 14:147-53. 2011
    ..mechanisms that underlie these processes are only partially understood, a series of recent papers point to awake memory replay as a potential contributor to both consolidation and retrieval...
  64. pmc Hippocampal "time cells" bridge the gap in memory for discontiguous events
    Christopher J MacDonald
    Center for Memory and Brain, Boston University, Boston, MA 02215, USA
    Neuron 71:737-49. 2011
    ..These findings suggest that hippocampal neural ensembles segment temporally organized memories much the same as they represent locations of important events in spatially defined environments...
  65. ncbi Memory--a century of consolidation
    J L McGaugh
    the Center for the Neurobiology of Learning and Memory and the Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697, USA
    Science 287:248-51. 2000
    The memory consolidation hypothesis proposed 100 years ago by Müller and Pilzecker continues to guide memory research...
  66. ncbi Human gamma-frequency oscillations associated with attention and memory
    Ole Jensen
    F C Donders Centre for Cognitive Neuroimaging, Kapittelweg 29, 6525 EN Nijmegen, The Netherlands
    Trends Neurosci 30:317-24. 2007
    ..suggested that gamma-frequency activity also has an important role in attention and both working and long-term memory. The involvement of gamma-band synchronization in various cognitive paradigms in humans is currently being ..
  67. ncbi A cognitive model of posttraumatic stress disorder
    A Ehlers
    Department of Psychiatry, University of Oxford, Warneford Hospital, UK
    Behav Res Ther 38:319-45. 2000
    ..1) excessively negative appraisals of the trauma and/or its sequelae and (2) a disturbance of autobiographical memory characterised by poor elaboration and contextualization, strong associative memory and strong perceptual priming...
  68. ncbi Neurogenesis in the adult is involved in the formation of trace memories
    T J Shors
    Department of Psychology and Center for Collaborative Neuroscience, Rutgers University, Piscataway, New Jersey 08854, USA
    Nature 410:372-6. 2001
    ..learning can enhance their survival; however, until now it was unknown whether new neurons are involved in memory formation...
  69. ncbi Alzheimer's disease is a synaptic failure
    Dennis J Selkoe
    Center for Neurologic Diseases, Brigham and Women s Hospital, and the Harvard Center for Neurodegeneration and Repair, Boston, MA 02115, USA
    Science 298:789-91. 2002
    In its earliest clinical phase, Alzheimer's disease characteristically produces a remarkably pure impairment of memory. Mounting evidence suggests that this syndrome begins with subtle alterations of hippocampal synaptic efficacy prior to ..
  70. ncbi Memory consolidation, retrograde amnesia and the hippocampal complex
    L Nadel
    Department of Psychology and Neural Systems, Memory and Aging Division, University of Arizona, Tucson, Arizona 85721, USA
    Curr Opin Neurobiol 7:217-27. 1997
    ..is extensive and can encompass much of a subject's lifetime; the degree of loss may depend upon the type of memory assessed...
  71. ncbi Recognition memory: what are the roles of the perirhinal cortex and hippocampus?
    M W Brown
    Medical Research Council, Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol Medical School, Bristol BS8 1TD, UK
    Nat Rev Neurosci 2:51-61. 2001
    The hallmark of medial temporal lobe amnesia is a loss of episodic memory such that patients fail to remember new events that are set in an autobiographical context (an episode). A further symptom is a loss of recognition memory...
  72. ncbi Applications of the Morris water maze in the study of learning and memory
    R D'hooge
    Laboratory of Neurochemistry and Behavior, Born Bunge Foundation, and Department of Neurology Memory Clinic, Middelheim Hospital, University of Antwerp, Universiteitsplein 1, B 2610, Antwerp, Belgium
    Brain Res Brain Res Rev 36:60-90. 2001
    The Morris water maze (MWM) was described 20 years ago as a device to investigate spatial learning and memory in laboratory rats. In the meanwhile, it has become one of the most frequently used laboratory tools in behavioral neuroscience...
  73. ncbi Models of visuospatial and verbal memory across the adult life span
    Denise C Park
    Department of Psychology, University of Michigan, Ann Arbor 48109, USA
    Psychol Aging 17:299-320. 2002
    The authors investigated the distinctiveness and interrelationships among visuospatial and verbal memory processes in short-term, working, and long-term memories in 345 adults...
  74. ncbi Regional dissociations within the hippocampus--memory and anxiety
    D M Bannerman
    Department of Experimental Psychology, University of Oxford, South Parks Road, OX1 3UD, UK
    Neurosci Biobehav Rev 28:273-83. 2004
    The amnestic effects of hippocampal lesions are well documented, leading to numerous memory-based theories of hippocampal function...
  75. pmc Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus
    Michael D Saxe
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:17501-6. 2006
    ..These data show that new hippocampal neurons can be preferentially recruited over mature granule cells in vitro and may provide a framework for how this small cell population can influence behavior...
  76. pmc Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory
    Farah D Lubin
    Department of Neurobiology, The Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Neurosci 28:10576-86. 2008
    Long-term memory formation requires selective changes in gene expression...
  77. pmc Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats
    Sebastian Jessberger
    Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Learn Mem 16:147-54. 2009
    ..Given the fundamental role of the hippocampus in processes underlying certain forms of learning and memory, it has been speculated that newborn granule cells contribute to cognition...
  78. doi Stress, memory and the amygdala
    Benno Roozendaal
    Department of Neuroscience, University Medical Center Groningen, University of Groningen, The Netherlands
    Nat Rev Neurosci 10:423-33. 2009
    ....
  79. doi Creating a false memory in the hippocampus
    Steve Ramirez
    RIKEN Massachusetts Institute of Technology Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Department of Biology, MIT, Cambridge, MA 02139, USA
    Science 341:387-91. 2013
    Memories can be unreliable. We created a false memory in mice by optogenetically manipulating memory engram-bearing cells in the hippocampus...
  80. ncbi Collective memory and spatial sorting in animal groups
    Iain D Couzin
    Centre for Biodiversity and Conservation, School of Biology, University of Leeds, Leeds, LS2 9JT, U K
    J Theor Biol 218:1-11. 2002
    ..Further, we present the first evidence for collective memory in such animal groups (where the previous history of group structure influences the collective behaviour exhibited ..
  81. pmc About sleep's role in memory
    Björn Rasch
    Division of Biopsychology, Neuroscience Center Zurich, University of Zurich, Zurich, Switzerland
    Physiol Rev 93:681-766. 2013
    Over more than a century of research has established the fact that sleep benefits the retention of memory. In this review we aim to comprehensively cover the field of "sleep and memory" research by providing a historical perspective on ..
  82. pmc Neural and cellular mechanisms of fear and extinction memory formation
    Caitlin A Orsini
    Department of Psychology, University of Michigan, 530 Church Street, Ann Arbor, MI 48109 1043, USA
    Neurosci Biobehav Rev 36:1773-802. 2012
    ..Of equal interest, though, is the neurobiology of extinction memory formation as this may shape current therapeutic techniques...
  83. doi Inhibitory plasticity balances excitation and inhibition in sensory pathways and memory networks
    T P Vogels
    School of Computer and Communication Sciences and Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne EPFL, Switzerland
    Science 334:1569-73. 2011
    ..Our results suggest an essential role of inhibitory plasticity in the formation and maintenance of functional cortical circuitry...
  84. doi A subset of dopamine neurons signals reward for odour memory in Drosophila
    Chang Liu
    Max Planck Institut fur Neurobiologie, Martinsried 82152, Germany
    Nature 488:512-6. 2012
    ..Despite recent advances in understanding the neural circuits for associative memory and appetitive motivation, the cellular mechanisms for reward processing in the fly brain are unknown...
  85. pmc Molecular mechanisms of fear learning and memory
    Joshua P Johansen
    Center for Neural Science, New York University, New York, NY 10003, USA
    Cell 147:509-24. 2011
    ..conditioning is a particularly useful behavioral paradigm for exploring the molecular mechanisms of learning and memory because a well-defined response to a specific environmental stimulus is produced through associative learning ..
  86. ncbi Neuronal signalling of fear memory
    Stephen Maren
    Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Rev Neurosci 5:844-52. 2004
    ..lesions and pharmacological inactivation provide evidence that the lateral amygdala is a crucial locus of fear memory. Extinction of fear memory reduces associative plasticity in the lateral amygdala and involves the hippocampus and ..
  87. doi Sleep-dependent memory triage: evolving generalization through selective processing
    Robert Stickgold
    Center for Sleep and Cognition, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Nat Neurosci 16:139-45. 2013
    ..with that information it chooses to keep? For information that is retained, sleep can integrate it into existing memory networks, look for common patterns and distill overarching rules, or simply stabilize and strengthen the memory ..
  88. pmc Implications of memory modulation for post-traumatic stress and fear disorders
    Ryan G Parsons
    Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
    Nat Neurosci 16:146-53. 2013
    ..We highlight recent progress in fear learning and memory, differential susceptibility to disorders of fear, and how these findings are being applied to the understanding, ..
  89. pmc Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior
    Jacqueline Blundell
    Departments of Neurology and Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390 8813, USA
    J Neurosci 30:2115-29. 2010
    ..NL1 knock-out (KO) mice display deficits in spatial learning and memory that correlate with impaired hippocampal long-term potentiation...
  90. pmc Neuronal synchrony reveals working memory networks and predicts individual memory capacity
    J Matias Palva
    Neuroscience Center, 00014 University of Helsinki, Finland
    Proc Natl Acad Sci U S A 107:7580-5. 2010
    Visual working memory (VWM) is used to maintain sensory information for cognitive operations, and its deficits are associated with several neuropsychological disorders...
  91. doi Dopamine and adaptive memory
    Daphna Shohamy
    Department of Psychology, Columbia University, New York, NY 10025, USA
    Trends Cogn Sci 14:464-72. 2010
    b>Memory is essential to adaptive behavior because it allows past experience to guide choices...
  92. doi NMDA receptor ablation on parvalbumin-positive interneurons impairs hippocampal synchrony, spatial representations, and working memory
    Tatiana Korotkova
    Department of Clinical Neurobiology, IZN, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
    Neuron 68:557-69. 2010
    ..Finally, NR1(PVCre-/-) mice exhibited impaired spatial working as well as spatial short- and long-term recognition memory but showed no deficits in open field exploratory activity and spatial reference learning.
  93. ncbi The human hippocampus and spatial and episodic memory
    Neil Burgess
    Institute of Cognitive Neuroscience and Department of Anatomy and Developmental Biology, University College London, 17 Queen Square, London, United Kingdom
    Neuron 35:625-41. 2002
    ..Our review of neuropsychological, behavioral, and neuroimaging studies of human hippocampal involvement in spatial memory concentrates on three important concepts in this field: spatial frameworks, dimensionality, and orientation and ..
  94. ncbi The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
    Michael F Egan
    Clinical Brain Disorders Branch, National Institute of Mental Health, Room 4s 235, 10 Center Drive, Bethesda, MD 20892, USA
    Cell 112:257-69. 2003
    Brain-derived neurotrophic factor (BDNF) modulates hippocampal plasticity and hippocampal-dependent memory in cell models and in animals...
  95. ncbi Perceptual symbol systems
    L W Barsalou
    Department of Psychology, Emory University, Atlanta, GA 30322, USA
    Behav Brain Sci 22:577-609; discussion 610-60. 1999
    ..attention, schematic representations of perceptual components are extracted from experience and stored in memory (e.g., individual memories of green, purr, hot)...
  96. pmc A cognitive training program based on principles of brain plasticity: results from the Improvement in Memory with Plasticity-based Adaptive Cognitive Training (IMPACT) study
    Glenn E Smith
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Geriatr Soc 57:594-603. 2009
    To investigate the efficacy of a novel brain plasticity-based computerized cognitive training program in older adults and to evaluate the effect on untrained measures of memory and attention and participant-reported outcomes.
  97. doi Effects of memory training on cortical thickness in the elderly
    Andreas Engvig
    Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Neuroimage 52:1667-76. 2010
    ..We examined the short-term effects of an intensive memory training program on cognition and brain structure in middle-aged and elderly healthy volunteers...
  98. pmc Rapid formation and selective stabilization of synapses for enduring motor memories
    Tonghui Xu
    Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA
    Nature 462:915-9. 2009
    ..However, how motor learning affects neuronal circuitry at the level of individual synapses and how long-lasting memory is structurally encoded in the intact brain remain unknown...
  99. ncbi Accounts of the confidence-accuracy relation in recognition memory
    T A Busey
    Department of Psychology, Indiana University, Bloomington 47405, USA
    Psychon Bull Rev 7:26-48. 2000
    Confidence and accuracy, while often considered to tap the same memory representation, are often found to be only weakly correlated (e.g., Bothwell, Deffenbacher, & Brigham, 1987; Deffenbacher, 1980)...
  100. pmc Identification of a genetic cluster influencing memory performance and hippocampal activity in humans
    Dominique J F de Quervain
    Division of Psychiatry Research and Center for Integrative Human Physiology, University of Zurich, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 103:4270-4. 2006
    Experimental work in animals has shown that memory formation depends on a cascade of molecular events...
  101. ncbi Beyond mind-reading: multi-voxel pattern analysis of fMRI data
    Kenneth A Norman
    Department of Psychology, Princeton University, Green Hall, Washington Road, Princeton, NJ 08540, USA
    Trends Cogn Sci 10:424-30. 2006
    ..We review how researchers are using MVPA methods to characterize neural coding and information processing in domains ranging from visual perception to memory search.

Research Grants81

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. James D Bryers; Fiscal Year: 2016
    ..biomaterial will transfect antigen-presenting cells (specifically dendritic cells - DCs) to produce T- and B-cell memory and antibody expression, and potentially stimulate direct native killer T-cell responses...
  3. Role of NGF in inflammatory and proliferative cascades of psoriatic disease
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..n=10)] will also be examined to identify an immunoregulatory role of NGF/NGF-R on PBMC and SF derived activated memory T cells...
  4. Importance of antigen specific immunoglobulin responses in controlling SIV/SHIV i
    Bapi Pahar; Fiscal Year: 2010
    ..The presence of low levels of memory B cells and defective naive B cells in HIV infected patients have also been reported...
  5. Tyrosine Availability Influences Mesocortico-Limbic Catecholamines
    GEORGE EUGENE JASKIW; Fiscal Year: 2012
    ..This affects how a person feels and how well he or she scores on tests of thinking and memory. This type of 'brain probe'has been used in over 26 studies over the last 6 years...
  6. Charles W Wilkinson; Fiscal Year: 2016
    ..Impairment of memory and concentration, increased anxiety, irritability and mood instability, and sleep disturbance interfere with job ..
  7. Regulation of B Cell Function by Membrane-Cytoskeletal Remodeling
    Neetu Gupta; Fiscal Year: 2012
    ..This provides the basis for memory that is generated during early childhood vaccinations...
  8. Statin modulation of immunotherapy for Alzheimer disease
    Jun Tan; Fiscal Year: 2012
    ..immunotherapy strategy in not only abrogating inflammation that may result from vaccination, but also in improving memory deficits in AD model mice...
  9. Schahram Akbarian; Fiscal Year: 2014
    ..genome-wide profiling, (d) behavioral assays measuring despair and learned helplessness, anxiety, and learning and memory and (e) functional characterization of NMDA receptors in hippocampus and other brain regions implicated in the ..
  10. Charlotte Cunningham-Rundles; Fiscal Year: 2015
    ..Project 1 - Investigating Blocks to B Cell Memory in CVID (Project Leader: Cunningham-Rundles, C...
  11. Novel PET imaging agents for early diagnosis of plaque deposition in Alzheimer's
    Padmakar Kulkarni; Fiscal Year: 2010
    ..protein tangles with in the brain cells tend to prevent neurons from communicating each other leading to loss of memory. Positron emission tomography (PET scan) can create image of the harmful beta amyoid plaque in the brains of ..
  12. Laura L Dugan; Fiscal Year: 2014
    ..Nox2, in turn, results in persistent deficits in inhibitory neural circuits required for learning, attention, and memory encoding...
  13. Ethanol Regulation of Serum Glucocorticoid Kinase I
    BLAIR N COSTIN; Fiscal Year: 2012
    ..Prior work by others also shows that Sgk1 can play an important role modulating synaptic plasticity occurring in memory. Based on these findings, it is hypothesized that Sgk1 induction might play an important role in modifying ..
  14. MARK L DELL'ACQUA; Fiscal Year: 2016
    ..a network of scaffolding proteins that play important roles during synaptic plasticity underlying learning and memory. AMPARs are recruited to dendritic spines through NMDAR activation during induction of long term potentiation (LTP)..
  15. Adenosine and the Basal Forebrain in the Control of Behavioral State
    Robert E Strecker; Fiscal Year: 2012
    ..Aim 2. What is the effect of CSR on spatial learning and memory (water maze), and on long term potentiation (LTP;a measure of synaptic plasticity important for memory formation)...
  16. John W Wiley; Fiscal Year: 2016
    ..psychological stress causes changes in epigenetic regulation of gene function in CNS regions associated with memory and mood...
  17. Alzheimer's Disease Therapeutic
    Trevor P Castor; Fiscal Year: 2012
    ..have also shown that bryostatin 1 not only produces a neuroprotective effect but also enhances cognitive memory in AD animal models...
  18. Chemical modulators of Tet-family proteins
    Anjana Rao; Fiscal Year: 2010
    ..suppressor genes;in the central nervous system (CNS), it has been implicated, among other things, in learning, memory and synaptic plasticity...
  19. Epigenomic Events in Development of the Locus Coeruleus Noradrenergic Neurons
    Jan Krzysztof Blusztajn; Fiscal Year: 2012
    ..LCNN constitute a critical component of the circuitry that is necessary for the processes of learning, memory, attention, sleep, arousal, anxiety, and responses to stress...
  20. Rafi Ahmed; Fiscal Year: 2016
    ..innate responses, to the peak effector T and B cell responses, to the development and maintenance of immunologic memory, (ii) To understand how a successful vaccine works, and to use this knowledge for designing strategies for ..
  21. Ken R Smith; Fiscal Year: 2015
    ..links biomarker data collected from two studies: Fertility, Longevity &Aging study (FLAG) and the Cache County Memory Study (CCMS). The purpose of this study is to address the following specific aims: Aim 1...
  22. Estrogen Modulation of Auditory Processing
    Raphael Pinaud; Fiscal Year: 2012
    ..brain's regulation of reproductive behavior, sexual development and cognitive processes such as learning and memory formation. Recent evidence suggests that estradiol (E2) also impacts auditory processing and perception...
  23. Aldosterone Action In The Brain, Hypertension and Inflammation
    ELISE PEERY GOMEZ-SANCHEZ; Fiscal Year: 2012
    ..In fact, the highest concentrations of MR are in hippocampal neurons involved in memory, learning and affect that also express AS...
  24. Cornelia M Weyand; Fiscal Year: 2016
    ..of the T cell pool, characterized by shrinkage of T cell diversity and accumulation of end-differentiated memory T cells biased toward pro-inflammatory effector functions, revealed a defect in T cell generation that imposes ..
  25. Efficacy of GABAA a5 receptor inverse agonists in learning impaired rats
    EARL MICHAEL GIBBS; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The number of patients in the United States afflicted with learning and memory disorders is rapidly increasing...
  26. David E Clapham; Fiscal Year: 2014
    ..of these studies should clarify receptor-mediated alteration of hippocampal-mediated spatial and contextual memory, and identify new therapeutic targets for diseases and surgeries that affect the hippocampus...
  27. Mucosal Memory T Cells at the Vanguard of Human Host Defense
    Donna L Farber; Fiscal Year: 2010
    ..only systemic immune responses and none specifically target mucosal sites nor do they promote durable, immune memory at mucosal sites...
  28. Photoperiod Brain and Behavior
    Randy J Nelson; Fiscal Year: 2012
    ..Male Peromyscus mice reduce hippocampal size and spatial memory performance in short days;short days decrease apical CA1 spine density and increase basilar CA3 spine density ..
  29. Mechanism of Age-Related Change in Estrogen Receptor Beta Expression in Rat Brain
    JENNE MITCHELL WESTBERRY; Fiscal Year: 2012
    ..in several non-reproductive brain functions such as protection against brain injury, involvement in learning and memory as well as promoting the formation of synapses...
  30. Effects of In Utero and Transgenerational Exposure of Avy Mice to Bisphenol A
    CHERYL SUSAN ROSENFELD; Fiscal Year: 2010
    ..assessments will be performed on the pups to determine whether BPA affects their anxiety levels, learning and memory responses, and other developmental parameters...
  31. Ai Ling Lin; Fiscal Year: 2016
    ..time this has been done;and, it will be the first study to investigate the correlation between cognitive effects (memory and spatial information processing) and brain imaging results in the CR mouse model...
  32. Gary B Kaplan; Fiscal Year: 2014
    ..BDNF's ability to increase protein synthesis in dendritic spines, alter connectivity and regulate long-term memory in COR extinction...
  33. Marcus Kaul; Fiscal Year: 2016
    ..that IFN? can inhibit HIV/gp120 from inducing neuronal damage and impairing neurogenesis and compromising memory and cognition by a unique combination of mechanisms, comprising the induction of neuroprotective ?-chemokines and ..
  34. Dopamine's Role in the Rapid Estradiol Enhancement of Excitatory Synapses
    CAROLINE COFER SMITH HAMILTON; Fiscal Year: 2013
    ..I have spent 10 years studying the mechanisms by which estradiol (E2) increases hippocampal dependent learning and memory. Through this exploration I uncovered a novel mechanism whereby E2 increases the magnitude of long-term ..
  35. Jun Zhang; Fiscal Year: 2014
    ..Patients with OSA suffer from fragmented sleep, chronic fatigue, daytime sleepiness, lack of concentration and memory problems with consequences including increased risk of motor vehicle accidents and the development of ..
  36. Henryk F Urbanski; Fiscal Year: 2014
    ..androgen supplementation on the severity of immune senescence by assessing: 1) the frequency of naive and memory T and B cell subsets;2) thymic output;3) plasma levels of key inflammatory cytokines;and inflammatory cytokine ..
  37. Robert L Nussbaum; Fiscal Year: 2014
    ..Finally, after completing a 10-generation backcross onto C57Bl/6, we will examine the mice for abnormalities in central nervous system by testing motor function, anxiety, learning, memory and by examining the brains neuropathologically.
  38. Albert Anderson; Fiscal Year: 2016
    ..in a mouse model of HIV encephalitis, treatment with IFN-alpha blockade was associated with a benefit in working memory and decreased pathological markers in the brain...
  39. Immune modulators of inflammation in servere COPD
    Farrah Kheradmand; Fiscal Year: 2010
    ..Using multiple approaches we will determine the memory response to regions within the elastin molecule that will serve as markers of downstream events that leads into ..
  40. The voltage-gated Kv1.3 channel in psoriatic disease: A novel therapeutic target
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..Autoreactive T cells appear to be crucial for the pathogenesis of psoriatic disease because of their memory phenotype and the ability of activated T lymphocytes to induce psoriasis in transplanted nonlesional skin in the ..
  41. Bruce S McEwen; Fiscal Year: 2015
    ..protective and adaptive for many processes such as avoidance of, and vigilance towards, threat, as well as memory, immune function and metabolism...
  42. E Sherwood Brown; Fiscal Year: 2014
    ..provided by applicant): In animals and humans, stress and corticosteroid excess is associated with changes in memory and hippocampal structure...
  43. Richard J Samulski; Fiscal Year: 2014
    ..Decreased transgene expression was seen in mice with memory OVA CTLs following liver transduction with AAV2-OVA vector...
  44. Design and Synthesis of Anxioselective Anxiolytics
    James M Cook; Fiscal Year: 2010
    ..binding, efficacy and pharmacology to understand the fundamental basis of/and treat anxiety disorders, as well as memory-impairment including age associated memory deficits...
  45. Environmental regulation of estrogen dependent aggression
    Brian C Trainor; Fiscal Year: 2013
    ..variety of processes in the brain and many aspects of behavior including social interactions, reproduction, and memory. A variety of estrogen receptors (ER) and signaling pathways make up a complex regulatory network that produces ..
  46. Zhongcong Xie; Fiscal Year: 2016
    ..with the gene mutation- or aging-induced elevation of A[unreadable] levels, leading to impairment of learning/memory and attention/executive function...
  47. Ephrin-A3 in Neuron-Glia Communication
    Elena B Pasquale; Fiscal Year: 2011
    ..This may represent a mechanism regulating spine remodeling during learning and memory formation...
  48. CLAIRE L MURPHY; Fiscal Year: 2015
    ..AD patients show early and dramatic loss of memory, and particularly odor memory, and they demonstrate profound olfactory dysfunction in old age (Murphy, et al...
  49. Nitric Oxide Signaling with Heme Proteins
    William R Montfort; Fiscal Year: 2012
    ..and is central to a wide-ranging array of physiological processes, including vasodilation, blood coagulation, memory formation, inflammation, angiogenesis, cell growth and cell death...
  50. Interacting Impact of Adrenal and Ovarian Aging on the CNS
    Henryk F Urbanski; Fiscal Year: 2011
    ..Cognitive and behavioral assessments will include: 1) delayed response test of spatial working memory, which is particularly sensitive to aging and prefrontal cortex dysfunction;2) delayed non- matching-to-sample, a ..
  51. David M Lyons; Fiscal Year: 2014
    ..Greater preferences for novelty during infancy predict higher scores on tests of intelligence, language, memory, and speed of information processing in children and young adults...
  52. Connexins in Neuronal and Glial Gap Junctions in the Central Nervous System
    John E Rash; Fiscal Year: 2012
    ..that are thought to underlie consciousness, arousal from sleep, cognition, associative binding for learning and memory, and fine motor control, and which become pathologically altered in epilepsy, schizophrenia, Parkinson's ..
  53. Engineering the Brain Immune System for Tumor Therapy
    Maria G Castro; Fiscal Year: 2013
    ..This combined approach induces tumor regression, long-lasting systemic immunological memory, and long-term survival in animals with large syngeneic tumors...
  54. Inhibition of matrix proteases to sensitize medulloblastoma cells to radiation
    Andrei L Gartel; Fiscal Year: 2013
    ..These can include deficits in memory, learning, and social/emotional adjustment, and growth problems...
  55. Neuroendocrine Mechanisms and Therapeutics in an Animal Model of PTSD
    DAVID MARK DIAMOND; Fiscal Year: 2013
    ..manipulation produces PTSD-like sequelae in rats, including heightened anxiety, exaggerated startle, impaired memory, greater cardiovascular and hormonal reactivity to an acute stressor and an exaggerated response to the 12-..
  56. Subbiah Pugazhenthi; Fiscal Year: 2016
    ..Cyclic AMP response element binding protein (CREB), a nuclear transcription factor, enhances cognition, memory formation and neuronal survival. CREB is known to be downregulated in the AD brain...
  57. Genome-wide DNA Methylation Profiles Associated with Abnormal Intrauterine Growth
    Cristina Montagna; Fiscal Year: 2013
    ..permanent alterations in gene expression implicate epigenetic regulation, which may serve as the biological memory of fetal conditions and may, in turn, be propagated to subsequent generations creating a transgenerational ..
  58. Christine T Cigolle; Fiscal Year: 2014
    ..a nationally-representative health interview survey, and data from the HRS supplemental Aging, Demographics, and Memory Study (ADAMS)...
  59. CD4+ T cells in Invasive Aspergillosis
    Amariliz Rivera; Fiscal Year: 2012
    ..fumigatus-specific, memory CD4 T cell responses and how are they elicited and regulated. In previous studies Dr...
  60. Immune Regulation of Viral Recrudescence
    Cornelia Bergmann; Fiscal Year: 2012
    ..within the CNS;and 2) determine the relative contribution of migratory ASC versus circulating, non Ab secreting memory B cells in maintaining ASC within the CNS...
  61. Ina E Djonlagic; Fiscal Year: 2014
    ..Dr. Stickgold is a leading researcher in the field of sleep, learning and memory. He is also a is a mentor on the T32 training grant of the Sleep Division at HMS and has published numerous ..
  62. Role of G-gamma-7 in striatal cannabinoid and D2 dopamine
    Dana E Selley; Fiscal Year: 2010
    ..endogenous cannabinoid system, which is involved in motivation and reward, motor control, appetite, learning and memory, and pain and thermoregulation...
  63. K-Channels in Lymphocyte Function and Autoimmunity
    GEORGE KANIANTHARA CHANDY; Fiscal Year: 2012
    ..One approach to achieving this lofty goal is to suppress and/or eliminate effector memory (TEM) cells that have been implicated in the pathogenesis of many autoimmune diseases without affecting other ..
  64. Treatment Implications of Trauma Memory Modulation for PTSD & Alcohol Dependence
    Michael E Saladin; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): This application, titled "Treatment Implications of Trauma Memory Modulation for PTSD &Alcohol Dependence", primarily addresses broad Challenge Area (15) Translational Science and specific ..
  65. Alina Suris; Fiscal Year: 2014
    ..Abstract There are very few systematic studies on humans that focus on changing the underlying traumatic memory once PTSD has been established...
  66. Memory, Thiamine Levels, and Brain Structure in Heart Failure
    MARY ANN WOO; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Short-term memory is an important component of outpatient management of heart failure (HF)...
  67. Scott R Sponheim; Fiscal Year: 2014
    ..The proposed treatment study draws upon recent research findings which suggest both that working memory is a critical, potentially performance-limiting, cognitive deficit in schizophrenia and that with intervention, ..
  68. Gene silencing of phosphodiesterase-4D (PDE4D) as a therapeutic approach to beta
    Han Ting Zhang; Fiscal Year: 2009
    ..Phosphodiesterase-4 (PDE4), an enzyme catalyzing the breakdown of cyclic AMP (cAMP), has been implicated in memory impairment associated with Alzheimer's disease (AD)...
  69. ANALYSIS OF A NOVEL SUBSET OF HUMAN CD8+ MEMORY CELLS WITH STEM CELL QUALITIES
    Stanley R Riddell; Fiscal Year: 2010
    ..The development and maintenance of memory T cells is a hallmark of the host response to acute and persistent viral infections and a major objective of ..
  70. REHABILITATION OF COGNITIVE SYMPTOMS IN MS
    John DeLuca; Fiscal Year: 2002
    ..The present proposal is designed to study the precise mechanism responsible for impaired working memory performance in patients with multiple sclerosis (MS), and to more closely test a rehabilitation strategy ..
  71. Calcium-Stimulated Adenylyl Cyclase Activity's Role in Stress-Facilitated Memory
    LINDSAY ANN WIECZOREK; Fiscal Year: 2010
    The long-term goal of this proposal is to provide insight into mechanisms critical for stress-facilitated memory formation, or in other words, the processing of memories under stressful conditions...
  72. Working Memory Performance among Childhood Brain Tumor Survivors
    HEATHER CONKLIN; Fiscal Year: 2009
    ..Recent research suggests that impairments in specific areas of functioning including attention, working memory and processing speed may be more proximal contributors to these global declines...
  73. CNS TARGETS OF PROPOFOL'S HYPNOTIC AND MEMORY EFFECTS
    ROBERT VESELIS; Fiscal Year: 2003
    Many sedative/hypnotic drugs used in anesthesia are given specifically to ablate memory formation during unpleasant medical experiences...
  74. SLEEP MEMORY: A MOLECULAR AND GENETIC ANALYSIS
    EDWIN ABEL; Fiscal Year: 2002
    ..the molecular machinery underlying sleep and to define the role of sleep in the consolidation of long-term memory. Sleep is involved in many physiological processes, and disturbances in sleep are a hallmark of many diseases, ..
  75. DECOMPOSITION OF MEMORY FAILURE IN ALZHEIMERS DISEASE
    John Gabrieli; Fiscal Year: 1999
    ..AD patients are impaired on all tests of explicit memory (e.g., recall and recognition of events, facts, and, in the laboratory, study-fist materials)...
  76. REGULATION OF CD8 T CELL IMMUNITY BY TNF RECEPTORS
    Marulasiddappa Suresh; Fiscal Year: 2001
    ..To confer protective immunity, vaccines against these agents need to elicit potent CD8+ T cell memory. Despite recognition of their importance in vaccinations, the underlying mechanisms in the generation of memory T ..
  77. Determining how adjuvants alter effector and memory T cells during vaccination
    Susan M Kaech; Fiscal Year: 2010
    ..and protecting against biological warfare attacks, and the success of a vaccine relies on generating long-lived memory T and B cells and plasma cells...