maze learning

Summary

Summary: Learning the correct route through a maze to obtain reinforcement. It is used for human or animal populations. (Thesaurus of Psychological Index Terms, 6th ed)

Top Publications

  1. ncbi A specific amyloid-beta protein assembly in the brain impairs memory
    Sylvain Lesne
    Department of Neurology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nature 440:352-7. 2006
  2. ncbi The human hippocampus and spatial and episodic memory
    Neil Burgess
    Institute of Cognitive Neuroscience and Department of Anatomy and Developmental Biology, University College London, 17 Queen Square, London, United Kingdom
    Neuron 35:625-41. 2002
  3. pmc Morris water maze: procedures for assessing spatial and related forms of learning and memory
    Charles V Vorhees
    Division of Neurology MLC 7044, Cincinnati Children s Research Foundation and Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Nat Protoc 1:848-58. 2006
  4. pmc Requirement for hippocampal CA3 NMDA receptors in associative memory recall
    Kazu Nakazawa
    Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 297:211-8. 2002
  5. ncbi Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice
    Radoslaw Rola
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, 94143, USA
    Exp Neurol 188:316-30. 2004
  6. pmc Adult-generated hippocampal neurons allow the flexible use of spatially precise learning strategies
    Alexander Garthe
    CRTD, Center for Regenerative Therapies Dresden, Dresden, Germany
    PLoS ONE 4:e5464. 2009
  7. ncbi Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis
    Jacob Raber
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, 97239, USA
    Radiat Res 162:39-47. 2004
  8. pmc Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats
    Sebastian Jessberger
    Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Learn Mem 16:147-54. 2009
  9. ncbi Applications of the Morris water maze in the study of learning and memory
    R D'hooge
    Laboratory of Neurochemistry and Behavior, Born Bunge Foundation, and Department of Neurology Memory Clinic, Middelheim Hospital, University of Antwerp, Universiteitsplein 1, B 2610, Antwerp, Belgium
    Brain Res Brain Res Rev 36:60-90. 2001
  10. ncbi Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network
    Thomas J McHugh
    Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 317:94-9. 2007

Detail Information

Publications272 found, 100 shown here

  1. ncbi A specific amyloid-beta protein assembly in the brain impairs memory
    Sylvain Lesne
    Department of Neurology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nature 440:352-7. 2006
    ..We propose that Abeta*56 impairs memory independently of plaques or neuronal loss, and may contribute to cognitive deficits associated with Alzheimer's disease...
  2. ncbi The human hippocampus and spatial and episodic memory
    Neil Burgess
    Institute of Cognitive Neuroscience and Department of Anatomy and Developmental Biology, University College London, 17 Queen Square, London, United Kingdom
    Neuron 35:625-41. 2002
    ....
  3. pmc Morris water maze: procedures for assessing spatial and related forms of learning and memory
    Charles V Vorhees
    Division of Neurology MLC 7044, Cincinnati Children s Research Foundation and Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Nat Protoc 1:848-58. 2006
    ..We present protocols for performing variants of the MWM test, from which results can be obtained from individual animals in as few as 6 days...
  4. pmc Requirement for hippocampal CA3 NMDA receptors in associative memory recall
    Kazu Nakazawa
    Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 297:211-8. 2002
    ..These results provide direct evidence for CA3 NMDA receptor involvement in associative memory recall...
  5. ncbi Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice
    Radoslaw Rola
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, 94143, USA
    Exp Neurol 188:316-30. 2004
    ..These data provide evidence that irradiation of young animals induces a long-term impairment of SGZ neurogenesis that is associated with hippocampal-dependent memory deficits...
  6. pmc Adult-generated hippocampal neurons allow the flexible use of spatially precise learning strategies
    Alexander Garthe
    CRTD, Center for Regenerative Therapies Dresden, Dresden, Germany
    PLoS ONE 4:e5464. 2009
    ..The discovery of highly specific behavioral deficits as consequence of a suppression of adult hippocampal neurogenesis thus allows to link cellular hippocampal plasticity to well-defined hypotheses from theoretical models...
  7. ncbi Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis
    Jacob Raber
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, 97239, USA
    Radiat Res 162:39-47. 2004
    ..The significant loss of proliferating SGZ cells and their progeny suggests a contributory role of reduced neurogenesis in the pathogenesis of radiation-induced cognitive impairments...
  8. pmc Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats
    Sebastian Jessberger
    Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Learn Mem 16:147-54. 2009
    ....
  9. ncbi Applications of the Morris water maze in the study of learning and memory
    R D'hooge
    Laboratory of Neurochemistry and Behavior, Born Bunge Foundation, and Department of Neurology Memory Clinic, Middelheim Hospital, University of Antwerp, Universiteitsplein 1, B 2610, Antwerp, Belgium
    Brain Res Brain Res Rev 36:60-90. 2001
    ..Through its many applications, MWM testing gained a position at the very core of contemporary neuroscience research...
  10. ncbi Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network
    Thomas J McHugh
    Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 317:94-9. 2007
    ..These results provide evidence that NMDA receptors in the granule cells of the dentate gyrus play a crucial role in the process of pattern separation...
  11. pmc Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning
    Jonathan L Brigman
    Sections on Behavioral Science and Genetics, Synaptic Pharmacology, and Neuronal Structure, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland 20852, USA
    J Neurosci 30:4590-600. 2010
    ....
  12. ncbi Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition
    Shoshanna Vaynman
    Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Eur J Neurosci 20:2580-90. 2004
    ..These findings suggest a functional role for CREB under the control of BDNF in mediating the exercise-induced enhancement in learning and memory. Our results indicate that synapsin I might also contribute to this BDNF-mediated mechanism...
  13. ncbi A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories
    M W Jones
    Division of Neurophysiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Nat Neurosci 4:289-96. 2001
    ..Thus, Zif268 is essential for the transition from short- to long-term synaptic plasticity and for the expression of long-term memories...
  14. ncbi Stress impairs performance in spatial water maze learning tasks
    C Holscher
    Department of Physiology, University College, Dublin, Ireland
    Behav Brain Res 100:225-35. 1999
    ..These results question the interpretations of the results of some previously published results of spatial water maze tasks...
  15. ncbi Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration
    Juan M Alarcon
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Neuron 42:947-59. 2004
    ....
  16. ncbi Hippocampal CA3 NMDA receptors are crucial for memory acquisition of one-time experience
    Kazu Nakazawa
    Howard Hughes Medical Institute, 77 Massachusetts Avenue, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 38:305-15. 2003
    ..These results suggest that CA3 NRs play a crucial role in rapid hippocampal encoding of novel information for fast learning of one-time experience...
  17. pmc Adult-born hippocampal dentate granule cells undergoing maturation modulate learning and memory in the brain
    Wei Deng
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 29:13532-42. 2009
    ..These results suggest that immature DGCs that undergo maturation make important contributions to learning and memory...
  18. ncbi Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning
    Toshiaki Nakashiba
    Picower Institute for Learning and Memory, Howard Hughes Medical Institute, RIKEN MIT Neuroscience Research Center, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 319:1260-4. 2008
    ..In contrast, the full trisynaptic pathway containing CA3 is required for rapid one-trial contextual learning, for pattern completion-based memory recall, and for spatial tuning of CA1 cells...
  19. ncbi A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
    D Morgan
    Department of Pharmacology, University of South Florida, Tampa 33612, USA
    Nature 408:982-5. 2000
    ..The A beta-vaccinated mice also had a partial reduction in amyloid burden at the end of the study. This therapeutic approach may thus prevent and, possibly, treat Alzheimer's dementia...
  20. ncbi Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit
    K Sakimura
    Department of Neuropharmacology, Niigata University, Japan
    Nature 373:151-5. 1995
    ..The mutant mice also showed a moderate deficiency in spatial learning. These results support the notion that the NMDA receptor channel-dependent synaptic plasticity is the cellular basis of certain forms of learning...
  21. ncbi Hippocampal plasticity across multiple days of exposure to novel environments
    Loren M Frank
    Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Neurosci 24:7681-9. 2004
    ..These results show that the hippocampus can form new spatial representations quickly but that stable hippocampal representations are not sufficient for a place to be treated as familiar...
  22. ncbi A role for adult neurogenesis in spatial long-term memory
    J S Snyder
    Department of Physiology, University of Toronto, 1 King s College Circle, Room 3214, Toronto, Ontario, Canada M5S 1A8
    Neuroscience 130:843-52. 2005
    ..These results suggest a new role for adult neurogenesis in the formation and/or consolidation of long-term, hippocampus-dependent, spatial memories...
  23. ncbi Essential role for TrkB receptors in hippocampus-mediated learning
    L Minichiello
    European Molecular Biology Laboratory, Heidelberg, Germany
    Neuron 24:401-14. 1999
    ..Interestingly, heterozygotes show a partial but substantial reduction of LTP but appear behaviorally normal. Thus, CA1 LTP may need to be reduced below a certain threshold before behavioral defects become apparent...
  24. pmc Environmental enrichment restores neurogenesis and rapid acquisition in aged rats
    Rachel B Speisman
    J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA
    Neurobiol Aging 34:263-74. 2013
    ....
  25. pmc Electromagnetic controlled cortical impact device for precise, graded experimental traumatic brain injury
    David L Brody
    Department of Neurology, Hope Center for Neurological Disorders, Washington University, St Louis, Missouri, USA
    J Neurotrauma 24:657-73. 2007
    ..0 mm with 7-8 mice per group. Thus, the EM impactor and refined surgical and behavioral testing techniques may offer a reliable and convenient framework for preclinical TBI research involving mice...
  26. ncbi Stimulation of entorhinal cortex promotes adult neurogenesis and facilitates spatial memory
    Scellig S D Stone
    Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada M5G1X8
    J Neurosci 31:13469-84. 2011
    ..Furthermore, because the beneficial effects of EC stimulation were prevented by blocking neurogenesis, this suggests a causal relationship between stimulation-induced promotion of adult neurogenesis and enhanced spatial memory...
  27. ncbi Control of memory formation through regulated expression of a CaMKII transgene
    M Mayford
    Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, and Howard Hughes Medical Institute, 722 West 168 Street, New York, NY 10032, USA
    Science 274:1678-83. 1996
    ..Thus, the CaMKII signaling pathway is critical for both explicit and implicit memory storage, in a manner that is independent of its potential role in development...
  28. ncbi Designing mouse behavioral tasks relevant to autistic-like behaviors
    Jacqueline N Crawley
    Mouse Behavioral Phenotyping Laboratory, Neurodevelopmental Disorders Research Center, University of North Carolina, Chapel Hill, North Carolina, USA
    Ment Retard Dev Disabil Res Rev 10:248-58. 2004
    ....
  29. ncbi Persistence of long-term memory storage requires a late protein synthesis- and BDNF- dependent phase in the hippocampus
    Pedro Bekinschtein
    Instituto de Biologia Celular y Neurociencias, UBA, Buenos Aires C1121ABG, Argentina
    Neuron 53:261-77. 2007
    ..We propose that memory formation and memory persistence share some of the same molecular mechanisms and that recurrent rounds of consolidation-like events take place in the hippocampus for maintenance of the memory trace...
  30. ncbi Neural ensembles in CA3 transiently encode paths forward of the animal at a decision point
    Adam Johnson
    Center for Cognitive Sciences, Univeristy of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 27:12176-89. 2007
    ..These data suggest that the hippocampus does not represent space as a passive computation, but rather that hippocampal spatial processing is an active process likely regulated by cognitive mechanisms...
  31. ncbi Hippocampal neurons encode information about different types of memory episodes occurring in the same location
    E R Wood
    Laboratory of Cognitive Neurobiology, Boston University, Massachusetts 02215, USA
    Neuron 27:623-33. 2000
    ..This pattern of results suggests that hippocampal representations encode some of the information necessary for representing specific memory episodes...
  32. ncbi The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease
    Marcus A Westerman
    Department of Neurology, Center for Clinical and Molecular Neurobiology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 22:1858-67. 2002
    ..These studies also provide a methodological framework within which to investigate these Abeta assemblies in vivo...
  33. ncbi The effects of regular aerobic exercise in adolescent period on hippocampal neuron density, apoptosis and spatial memory
    Nazan Uysal
    Dokuz Eylul University Medical Faculty Physiology Department, Izmir, Tuykey
    Neurosci Lett 383:241-5. 2005
    ..This result may derive from treadmill exercise-induced increase cell density without altering of apoptosis in the hippocampus and dentate gyrus of adolescent rats...
  34. ncbi A role in learning for SRF: deletion in the adult forebrain disrupts LTD and the formation of an immediate memory of a novel context
    Amit Etkin
    Center for Neurobiology and Behavior, Columbia University Medical Center, 1051 Riverside Drive, New York, New York 10032, USA
    Neuron 50:127-43. 2006
    ....
  35. ncbi Hippocampal lesions that abolish spatial maze performance spare object recognition memory at delays of up to 48 hours
    S E Forwood
    Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom
    Hippocampus 15:347-55. 2005
    ..These rats were also tested on a spatial nonmatching-to-place task. Spatial memory performance was abolished following hippocampal lesions, whereas performance on the recognition memory task was intact at all delays tested...
  36. pmc Spatial memory consolidation is associated with induction of several lysine-acetyltransferase (histone acetyltransferase) expression levels and H2B/H4 acetylation-dependent transcriptional events in the rat hippocampus
    Olivier Bousiges
    INSERM, U692, Laboratoire de Signalisations Moléculaires et Neurodégénérescence, Strasbourg, France
    Neuropsychopharmacology 35:2521-37. 2010
    ..These findings suggest the use of HAT-activating molecules in new therapeutic strategies of pathological aging, Alzheimer's disease, and other neurodegenerative disorders...
  37. pmc Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2
    Mauro Costa-Mattioli
    Department of Biochemistry and McGill Cancer Center, Montreal, Quebec, Canada
    Nature 436:1166-73. 2005
    ..Our study provides genetic, physiological, behavioural and molecular evidence that GCN2 regulates synaptic plasticity, as well as learning and memory, through modulation of the ATF4/CREB pathway...
  38. pmc Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease
    Colm Cunningham
    Department of Biochemistry, Trinity College Institute of Neuroscience, Trinity College Dublin, Republic of Ireland
    Biol Psychiatry 65:304-12. 2009
    ....
  39. pmc Neurogenesis may relate to some but not all types of hippocampal-dependent learning
    Tracey J Shors
    Department of Psychology and Center for Collaborative Neuroscience, Rutgers University, Piscataway, New Jersey 08854 8020, USA
    Hippocampus 12:578-84. 2002
    ..Nor did MAM treatment affect exploration in the elevated plus maze. These results combined with previous ones suggest that neurogenesis may be associated with the formation of some but not all types of hippocampal-dependent memories...
  40. ncbi Animal models of anxiety: do I need multiple tests?
    Andre Ramos
    Laboratório de Genética do Comportamento, Departamento de Biologia Celular, Embriologia e Genetica, Universidade Federal de Santa Catarina, 88 040 900, Florianopolis, SC, Brazil
    Trends Pharmacol Sci 29:493-8. 2008
    ....
  41. ncbi Age-related changes in brain metabolites and cognitive function in APP/PS1 transgenic mice
    Shuang Qing Chen
    Department of Radiology, Suzhou Hospital, Nanjing Medical University, Suzhou 215001, China
    Behav Brain Res 235:1-6. 2012
    ..These results indicated that metabolic changes preceded overt cognitive dysfunctions in early-stage AD, suggesting that (1)H-MRS is a more sensitive biomarker for assessing early AD...
  42. pmc Intermittent hypoxia-induced cognitive deficits are mediated by NADPH oxidase activity in a murine model of sleep apnea
    Deepti Nair
    Department of Pediatrics, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 6:e19847. 2011
    ..Excessive NADPH oxidase activity may play a role in IH-induced CNS dysfunction...
  43. ncbi Hippocampal expression analyses reveal selective association of immediate-early, neuroenergetic, and myelinogenic pathways with cognitive impairment in aged rats
    Wayne B Rowe
    Department of Functional Neuroscience, Memory Pharmaceuticals Corporation, Montvale, New Jersey 07645, USA
    J Neurosci 27:3098-110. 2007
    ..Together, the findings suggest a new model, in which deficient neuroenergetics leads to downregulated neuronal signaling and increased glial activation, resulting in aging-related cognitive dysfunction...
  44. pmc Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment
    Inga Kadish
    Department of Cell Biology, University of Alabama, Birmingham, Alabama 35294, USA
    J Neurosci 29:1805-16. 2009
    ..Well powered microarray analyses (N = 49 arrays), immunohistochemistry, and Morris spatial maze learning were used to study male F344 rats at five age points...
  45. ncbi Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships to beta-amyloid deposition and neurotransmitter abnormalities
    Alena Savonenko
    Department of Pathology, Johns Hopkins School of Medicine, Ross Building, Room 558, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Neurobiol Dis 18:602-17. 2005
    ....
  46. pmc Cognitive impairment following high fat diet consumption is associated with brain inflammation
    Paul J Pistell
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, United States
    J Neuroimmunol 219:25-32. 2010
    ..Collectively, these data suggest that while different diet formulations can increase body weight, the ability of high fat diets to disrupt cognition is linked to brain inflammation...
  47. pmc Cyclooxygenase-2-specific inhibitor improves functional outcomes, provides neuroprotection, and reduces inflammation in a rat model of traumatic brain injury
    Jonas J Gopez
    Department of Neurosurgery, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Neurosurgery 56:590-604. 2005
    ..A growing literature supports the benefit of COX2-specific inhibitors in treating brain injuries...
  48. ncbi Place cells and place recognition maintained by direct entorhinal-hippocampal circuitry
    Vegard H Brun
    Neuroscience Unit, Medical Technical Research Centre, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Science 296:2243-6. 2002
    ..These results suggest that the hippocampus contains two functionally separable memory circuits: The direct entorhinal-CA1 system is sufficient for recollection-based recognition memory, but recall depends on intact CA3-CA1 connectivity...
  49. ncbi Anxiolytic effects of Lavandula angustifolia odour on the Mongolian gerbil elevated plus maze
    B F Bradley
    Department of Psychology, University of Central Lancashire, Preston, Lancashire, UK
    J Ethnopharmacol 111:517-25. 2007
    ..In addition, prolonged, 2-week lavender odour exposure increased exploratory behaviour in females indicating a further decrease in anxiety in this sex...
  50. ncbi Fragmentation of grid cell maps in a multicompartment environment
    Dori Derdikman
    Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, MTFS, Norwegian University of Science and Technology, Trondheim, Norway
    Nat Neurosci 12:1325-32. 2009
    ..These results indicate that spatial environments are represented in entorhinal cortex and hippocampus as a mosaic of discrete submaps that correspond to the geometric structure of the space...
  51. ncbi Peripheral infection and aging interact to impair hippocampal memory consolidation
    Ruth M Barrientos
    Department of Psychology and Center for Neuroscience, University of Colorado at Boulder, Campus Box 345, Boulder, CO 80309 0345, USA
    Neurobiol Aging 27:723-32. 2006
    ..It is possible that this cognitive vulnerability is mediated by age-related changes in the glial environment that results in an exaggerated brain pro-inflammatory response to infection...
  52. ncbi Is there a geometric module for spatial orientation? Insights from a rodent navigation model
    Denis Sheynikhovich
    Laboratory of Computational Neuroscience, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Psychol Rev 116:540-66. 2009
    ..Moreover, the same model also describes behavioral results in different types of water-maze tasks...
  53. ncbi Sex-differences in age-related cognitive decline in C57BL/6J mice associated with increased brain microtubule-associated protein 2 and synaptophysin immunoreactivity
    T S Benice
    Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, 97239, USA
    Neuroscience 137:413-23. 2006
    ..Elevated levels of microtubule-associated protein 2 and synaptophysin may constitute a compensatory response to age-related functional decline in mice...
  54. pmc Reduced fear expression after lesions of the ventral hippocampus
    Kirsten G Kjelstrup
    Neuroscience Unit, Norwegian University of Science and Technology, MTFS, 7489 Trondheim, Norway
    Proc Natl Acad Sci U S A 99:10825-30. 2002
    ..Ventral lesions failed to impair contextual fear conditioning or spatial navigation, suggesting that the ventral hippocampus may specifically influence some types of defensive fear-related behavior...
  55. ncbi Genetic enhancement of learning and memory in mice
    Y P Tang
    Department of Molecular Biology, Princeton University, New Jersey 08544 1014, USA
    Nature 401:63-9. 1999
    ..Our results suggest that genetic enhancement of mental and cognitive attributes such as intelligence and memory in mammals is feasible...
  56. ncbi A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease
    G Chen
    Department of Neuroscience, University of Edinburgh, UK
    Nature 408:975-9. 2000
    ....
  57. ncbi Memory reconsolidation and extinction have distinct temporal and biochemical signatures
    Akinobu Suzuki
    Department of Agricultural Chemistry, Faculty of Applied Bioscience, Tokyo University of Agriculture, Tokyo 156 8502, Japan
    J Neurosci 24:4787-95. 2004
    ..These studies demonstrate the dynamic nature of memory processing after retrieval and represent a first step toward a molecular dissection of underlying mechanisms...
  58. ncbi Extrahippocampal contributions to age differences in human spatial navigation
    Scott D Moffat
    Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI 48202, USA
    Cereb Cortex 17:1274-82. 2007
    ..We conclude that human navigation requires both hippocampal and extrahippocampal brain systems and draws on executive resources for successful performance...
  59. ncbi Assessment of spatial memory in mice
    Sunita Sharma
    University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58203, USA
    Life Sci 87:521-36. 2010
    ..The advantages and limitations of the behavioral models in assessing memory and the link to the long-term potentiation are discussed. This review should assist investigators in choosing suitable methods to assess spatial memory in mice...
  60. ncbi Contribution of hippocampal and extra-hippocampal NR2B-containing NMDA receptors to performance on spatial learning tasks
    Jakob von Engelhardt
    Department of Clinical Neurobiology, University of Heidelberg, D 69120 Heidelberg, Germany
    Neuron 60:846-60. 2008
    ..Thus, both hippocampal and extra-hippocampal NR2B containing NMDA receptors critically contribute to spatial performance...
  61. ncbi A study in male and female 5-HT transporter knockout rats: an animal model for anxiety and depression disorders
    J D A Olivier
    Department of Cognitive Neuroscience Psychoneuropharmacology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Neuroscience 152:573-84. 2008
    ..This knockout rat model may provide a valuable model to study anxiety- and depression-related disorders in male and female rats...
  62. ncbi Ventral hippocampal lesions affect anxiety but not spatial learning
    D M Bannerman
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, OX1 3UD, UK
    Behav Brain Res 139:197-213. 2003
    ....
  63. ncbi Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus
    Yanjie Wan
    Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London
    Anesthesiology 106:436-43. 2007
    ..The authors investigated the role of cytokine-mediated inflammation within the central nervous system in the development of cognitive dysfunction in a rat model...
  64. ncbi Differential impact of juvenile stress and corticosterone in juvenility and in adulthood, in male and female rats
    Shlomit Jacobson-Pick
    Department of Neurobiology, University of Haifa, Mount Carmel, 31905 Haifa, Israel
    Behav Brain Res 214:268-76. 2010
    ..The application of CORT induced a similar reversed behavioral pattern in juvenile and adult rats of both sexes. Thus, the juvenile stress model might serve as an animal model for studying early-onset of affective illness...
  65. ncbi Chronic stress induces impairment of spatial working memory because of prefrontal dopaminergic dysfunction
    K Mizoguchi
    Pharmacology Department, Central Research Laboratories, Tsumura and Company, Ami Machi, Inashiki Gun, Ibaraki 300 1192, Japan
    J Neurosci 20:1568-74. 2000
    ..These findings provide important information for understanding of the mechanisms underlying PFC dysfunction in stress-related neuropsychiatric disorders...
  66. ncbi Cognitive strategies dependent on the hippocampus and caudate nucleus in human navigation: variability and change with practice
    Giuseppe Iaria
    Douglas Hospital Research Center, McGill University, Verdun, Quebec, Canada, H4H 1R3
    J Neurosci 23:5945-52. 2003
    ..Activation common to both groups was observed in the posterior parietal and frontal cortex. These results provide the first evidence for spontaneous variability and shift in neural mechanisms during navigation in humans...
  67. ncbi Strain and gender differences in the behavior of mouse lines commonly used in transgenic studies
    V Voikar
    Laboratory of Molecular Neurobiology, Institute of Biotechnology, University of Helsinki, PO Box 56, Viikinkaari 5, FIN 00014 Helsinki, Finland
    Physiol Behav 72:271-81. 2001
    ....
  68. pmc Hippocampal long-term depression is required for the consolidation of spatial memory
    Yuan Ge
    Brain Research Centre, University of British Columbia, BC, Canada V6T 2B5
    Proc Natl Acad Sci U S A 107:16697-702. 2010
    ..Taken together, our findings support a functional requirement of hippocampal CA1 LTD in the consolidation of long-term spatial memory...
  69. ncbi Sevoflurane impairs memory consolidation in rats, possibly through inhibiting phosphorylation of glycogen synthase kinase-3β in the hippocampus
    Xue Sheng Liu
    Department of Anesthesiology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, PR China
    Neurobiol Learn Mem 94:461-7. 2010
    ..Sevoflurane-induced amnesia may be due, at least in part, to suppression of GSK-3β phosphorylation in the hippocampus...
  70. pmc Isoflurane induces hippocampal cell injury and cognitive impairments in adult rats
    Daowei Lin
    Department of Anesthesiology, University of Virginia, Charlottesville, VA 22908, USA
    Neuropharmacology 61:1354-9. 2011
    ..These results suggest that isoflurane increases inflammatory cytokine expression and causes cell injury in the hippocampus, which may contribute to isoflurane-induced cognitive impairment in rats...
  71. pmc Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network
    Julie A Harris
    Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
    Neuron 68:428-41. 2010
    ..Thus, APP/Aβ expression in EC neurons causes transsynaptic deficits that could initiate the cortical-hippocampal network dysfunction in mouse models and human patients with AD...
  72. ncbi Environmental impoverishment and aging alter object recognition, spatial learning, and dentate gyrus astrocytes
    Daniel G Diniz
    Universidade Federal do Para UFPA, Instituto de Ciencias Biologicas, Hospital Universitário João de Barros Barreto, Brazil
    Eur J Neurosci 32:509-19. 2010
    ..We suggest that long-term experience-induced glial plasticity by enriched environment may represent at least part of the circuitry groundwork for improvements in behavioral performance in the aged mice brain...
  73. ncbi A double dissociation between the effects of sub-pyrogenic systemic inflammation and hippocampal lesions on learning
    David J Sanderson
    Department of Experimental Psychology, University of Oxford, Oxford, UK
    Behav Brain Res 201:103-11. 2009
    ..However, the double dissociation between the effects of LPS and hippocampal lesions demonstrate that sub-pyrogenic inflammation does not affect learning by disrupting hippocampal function...
  74. ncbi Exposure to juvenile stress exacerbates the behavioural consequences of exposure to stress in the adult rat
    Avi Avital
    Department of Psychology and The Brain and Behavior Research Center, University of Haifa, Mount Carmel, Haifa, Israel
    Int J Neuropsychopharmacol 8:163-73. 2005
    ..These results indicate that an exposure to a relatively brief juvenile stressful experience has profound and long-lasting effects on the ability to cope with stress in adulthood...
  75. ncbi Possible regulatory mechanism of DHA-induced anti-stress reaction in rats
    Takashi Takeuchi
    Department of Veterinary Physiology, Faculty of Agriculture, Tottori University, Tottori 680 0945, Japan
    Brain Res 964:136-43. 2003
    ..Significantly, the DHA supplemented group was not affected by the pre-treatment with bicuculline. From these findings, it is concluded that the involvement of DHA in stress responses may act via a GABA(A) receptor-mediated mechanism...
  76. pmc Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior
    Charles A Hoeffer
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 60:832-45. 2008
    ..Our results indicate that FKBP12 plays a critical role in the regulation of mTOR-Raptor interactions, LTP, memory, and perseverative behaviors...
  77. ncbi Molarless-induced changes of spines in hippocampal region of SAMP8 mice
    Kin ya Kubo
    Department of Oral Anatomy, Division of Oral Structure, Function and Development, Asahi University School of Dentistry, 1851 Hozumi, Mizuho, Gifu 501 0296, Japan
    Brain Res 1057:191-5. 2005
    ..The results suggest the involvement of the molarless condition in an attenuation of input activities in the hippocampal synapses...
  78. ncbi NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation
    E Shimizu
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    Science 290:1170-4. 2000
    ..Such a synaptic reinforcement process may also serve as a cellular means by which the new memory is transferred from the hippocampus to the cortex for permanent storage...
  79. ncbi Long-term impairment of acquisition of a spatial memory task following isoflurane-nitrous oxide anesthesia in rats
    Deborah J Culley
    Department of Anesthesia, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Anesthesiology 100:309-14. 2004
    ..This experiment was designed to test the hypothesis that learning of new information is particularly susceptible to prolonged disruption after general anesthesia...
  80. ncbi Different data from different labs: lessons from studies of gene-environment interaction
    Douglas Wahlsten
    Centre for Neuroscience and Department of Psychology, University of Alberta, Edmonton, AB T6G 2E9, Canada
    J Neurobiol 54:283-311. 2003
    ..Implications for behavioral screening of targeted and induced mutations in mice are discussed...
  81. ncbi Effects of cytotoxic hippocampal lesions in mice on a cognitive test battery
    Robert M J Deacon
    Department of Experimental Psychology, University of Oxford, South Parks Road, UK
    Behav Brain Res 133:57-68. 2002
    ..These results are largely consistent with findings in hippocampal lesioned rats on the same or similar tasks, and reflect a major impairment of spatial cognition, with relative sparing of non-spatial task performance...
  82. ncbi Strain differences in sucrose preference and in the consequences of unpredictable chronic mild stress
    Stéphanie Pothion
    Key Obs SA, Parc Technologique, 3 allée du Titane, 16 rue Leonard de Vinci, 45100 Orleans, France
    Behav Brain Res 155:135-46. 2004
    ..In the Y-maze, UCMS did not modify spontaneous alternation. These results show both an anhedonic-like and an amnesic effect of UCMS in CBA/H mice. They also reveal a difference of sensitivity to UCMS according to the strain of mice...
  83. ncbi Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues
    F Crestani
    Institute of Pharmacology, Swiss Federal Institute of Technology ETH and University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Nat Neurosci 2:833-9. 1999
    ..This model implicates GABAA-receptor dysfunction in patients as a causal predisposition to anxiety disorders...
  84. ncbi Double dissociation between the effects of peri-postrhinal cortex and hippocampal lesions on tests of object recognition and spatial memory: heterogeneity of function within the temporal lobe
    Boyer D Winters
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 24:5901-8. 2004
    ..These results provide strong evidence in favor of heterogeneity and independence of function within the temporal lobe...
  85. pmc Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior
    A C Basu
    Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
    Mol Psychiatry 14:719-27. 2009
    ....
  86. ncbi Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3
    Mona Shahbazian
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 35:243-54. 2002
    ....
  87. pmc Spatial learning depends on both the addition and removal of new hippocampal neurons
    David Dupret
    INSERM U862, Bordeaux Neuroscience Research Center, Bordeaux, France
    PLoS Biol 5:e214. 2007
    ..In conclusion, during learning, similar to the selective stabilization process, neuronal networks are sculpted by a tightly regulated selection and suppression of different populations of newly born neurons...
  88. pmc The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress
    Michael Lutter
    Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390 9077, USA
    Nat Neurosci 11:752-3. 2008
    ..Together, these findings demonstrate a previously unknown function for ghrelin in defending against depressive-like symptoms of chronic stress...
  89. ncbi Two-day radial-arm water maze learning and memory task; robust resolution of amyloid-related memory deficits in transgenic mice
    Jennifer Alamed
    Alzheimer s Research Laboratory, Department of Molecular Pharmacology and Physiology, School of Basic Biomedical Sciences, College of Medicine, Tampa, Florida 33612, USA
    Nat Protoc 1:1671-9. 2006
    ..With two sessions each day, 16 mice can be tested over 2 days...
  90. ncbi Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat
    T M Madsen
    Laboratory of Neuropsychiatry, Department of Psychiatry O 6102, H S Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark
    Neuroscience 119:635-42. 2003
    ....
  91. ncbi GM-CSF upregulated in rheumatoid arthritis reverses cognitive impairment and amyloidosis in Alzheimer mice
    Tim D Boyd
    USF Health Byrd Alzheimer s Center and Research Institute, Tampa, FL 33613, USA
    J Alzheimers Dis 21:507-18. 2010
    ....
  92. ncbi A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
    C Janus
    Centre for Research in Neurodegenerative Diseases, Department of Medicine, University of Toronto, Ontario, Canada
    Nature 408:979-82. 2000
    ..This implies that either a approximately 50% reduction in dense-cored A beta plaques is sufficient to affect cognition, or that vaccination may modulate the activity/abundance of a small subpopulation of especially toxic A beta species...
  93. pmc Enhanced long-term and impaired short-term spatial memory in GluA1 AMPA receptor subunit knockout mice: evidence for a dual-process memory model
    David J Sanderson
    Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom
    Learn Mem 16:379-86. 2009
    ..Thus, these results support a dual-process model of memory in which short-term and long-term memory are separate and sometimes competitive processes...
  94. pmc Potential adaptive function for altered long-term potentiation mechanisms in aging hippocampus
    Katica Boric
    Mind Brain Institute and Department of Neurosciences, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Neurosci 28:8034-9. 2008
    ....
  95. ncbi Ethological and temporal analyses of anxiety-like behavior: the elevated plus-maze model 20 years on
    A P Carobrez
    Departamento de Farmacologia, CCB, Universidade Federal de Santa Catarina, Florianopolis, SC, 88049 900, Brazil
    Neurosci Biobehav Rev 29:1193-205. 2005
    ..It is hoped that this review can provide insights into the optimal use of the EPM, a simple task that can be very complex in terms of behavioral analysis...
  96. ncbi Decreased behavioral impairments in an Alzheimer mice model by interfering with TNF-alpha metabolism
    Fabienne Giuliani
    Department of Psychiatry, CHUV, Center for Psychiatric Neuroscience, Lausanne, Switzerland
    Brain Res Bull 80:302-8. 2009
    ..These data indicate that PDAPP mice express cognitive impairments disregarding absence of TNF. The pathological behavioral anomalies related to the PDAPP mutation seem reduced by treatments interfering with TNFalpha...
  97. pmc Lidocaine attenuates cognitive impairment after isoflurane anesthesia in old rats
    Daowei Lin
    Department of Anesthesiology, University of Virginia, 1 Hospital Drive, Charlottesville, VA 22908, USA
    Behav Brain Res 228:319-27. 2012
    ..Thus, isoflurane induces learning and memory impairment in old rats. Lidocaine attenuates these isoflurane effects. Isoflurane may not cause long-lasting neuropathological changes...
  98. pmc 7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease
    Latha Devi
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY 10962, USA
    Neuropsychopharmacology 37:434-44. 2012
    ..Together, our findings indicate that TrkB activation with systemic 7,8-DHF can ameliorate AD-associated memory deficits, which may be, at least in part, attributable to reductions in BACE1 expression and β-amyloidogenesis...
  99. ncbi The role of granulocyte-colony stimulating factor (G-CSF) in the healthy brain: a characterization of G-CSF-deficient mice
    Kai Diederich
    Department of Neurology, University of Muenster, 48149 Muenster, Germany
    J Neurosci 29:11572-81. 2009
    ....
  100. ncbi The impact of environmental enrichment in laboratory rats--behavioural and neurochemical aspects
    Joy Simpson
    Department of Pharmacology and Therapeutics, National University of Ireland, Galway, Ireland
    Behav Brain Res 222:246-64. 2011
    ..EE, as is provided in many laboratories, may be of benefit to the animals, however it is important that future work aims to provide a better understanding of EE effects on research outcomes...
  101. ncbi The toxicological effects in brain of mice following exposure to cerium chloride
    Haiquan Zhao
    Medical College of Soochow University, Suzhou, 215123, People s Republic of China
    Biol Trace Elem Res 144:872-84. 2011
    ..Therefore, our study aroused the attention of Ln application and long-term exposure effects...

Research Grants67

  1. DEVELOPMENTAL EFFECTS OF METHLENEDIOXYMETHAMPHETAMINE
    Charles Vorhees; Fiscal Year: 2002
    ..to late in utero stages of human development) results in long-lasting deficits in spatial and sequential water maze learning and memory...
  2. REM SLEEP DEPRIVATION, HYPOXIA, AND HIPPOCAMPAL FUNCTION
    David Gozal; Fiscal Year: 2003
    ..trained animals following REMSD, EHYP, or both; (4) Alterations in early gene induction (c-fos) elicited by maze learning procedures will be further assessed in the hippocampus of REMSD, EHYP, and REMSD-EHYP by immunohistochemistry ..
  3. Genetic regulation of hippocampal anatomy and learning
    WIM CRUSIO; Fiscal Year: 2009
    ..The genetic correlation between the size of the IIPMF and radial maze learning is around 0.90, indicating that about 80% of the genetic variation is shared...
  4. UNC-CH NADIA Underage Drinking and Adult Brain Morphology in Rats
    Fulton T Crews; Fiscal Year: 2013
    ..These studies will determine if models of underage drinking result in persistent structural, cellular, and neuronal activation responses that impact adult brain networks and behavior. ..
  5. Role of beta catenin mediated neural stem cell and astrocyte proliferation in TBI
    Diana M Sama; Fiscal Year: 2013
    ..are predicted to result in greater cognitive impairment, which will be evaluated using a Morris Water Maze learning paradigm and Novel Object Recognition (memory) Task...
  6. ETHANOL AFFECTS HYPOTHALAMIC-DENTATE GYRUS INTERACTIONS
    MATTHEW WAYNER; Fiscal Year: 2001
    ..Ethanol drinking or ethanol applied directly to the LHA also inhibits LTP as well as impairs maze learning. Both the impairment of maze learning and LTP inhibition can be prevented by pretreatment with losartan...
  7. PREGNANCY & NEURAL & BEHAVIORAL PLASTICITY IN THE FEMALE
    CRAIG KINSLEY; Fiscal Year: 1999
    ..result in enhanced learning ability? Experiment 3: What is the role of pup stimulation in enhancement of maze learning? SPECIFIC AIM 2...
  8. Marine Toxin Impacts on Neurobehavioral Function
    Edward Levin; Fiscal Year: 2003
    ..The forum will provide an opportunity for methodological and theoretical issues to be integrated in the context of each talk as well as in a discussion session at the end of the symposium. ..
  9. Adolescence: A Sensitive Period for Nicotine Addiction
    Edward Levin; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  10. Behavioral Genetics and Toxic Response
    Edward Levin; Fiscal Year: 2002
    ....
  11. Nicotinic-Antipsychotic Drug Interactions and Cognition
    Edward Levin; Fiscal Year: 2006
    ..abstract_text> ..
  12. Effects of Neonatal MDMA on Brain and Behavior
    Charles V Vorhees; Fiscal Year: 2010
    ....
  13. DEVELOPMENTAL EFFECTS OF METHAMPHETAMINE-LIKE STIMULANTS
    Charles Vorhees; Fiscal Year: 2009
    ..The number of prenatally MA exposed children continues to grow. Our goal is to develop models of early MA exposure that permit an understanding of the long-term consequences on brain development and cognition. ..
  14. Neurobehavioral effects of adolescent GHB
    Ratna Sircar; Fiscal Year: 2007
    ..Such information will be relevant to GHB exposure in human adolescents, and help in the development of novel prevention and/or treatment strategies. ..
  15. LONG TERM HIPPOCAMPAL MEMORY
    Pramod Dash; Fiscal Year: 2001
    ..Understanding the molecular basis of memory storage will be of value in the future development of pharmacological agents to treat amnesia associated with neurological disorders and other mental health related problems. ..
  16. Determining Therapeutic Efficacy of AGE in AD
    Neelima Chauhan; Fiscal Year: 2005
    ..If successful, this project will validate the use of safe, naturally well-tolerated, cost-effective and alternative herbal pharmacotherapy for treating AD. ..
  17. Significance of Stress-Induced Hippocampal Atrophy
    CHERYL CONRAD; Fiscal Year: 2006
    ..abstract_text> ..
  18. ALCOHOL EXPOSURE EFFECTS: GENETIC BASIC
    David Blizard; Fiscal Year: 2006
    ..Overall, these studies will establish a mouse model for the study of genetic factors and sex as they influence individual differences in response to ethanol exposure during adolescence and early adult life. ..
  19. Prefrontal cortex and memory storage
    Pramod K Dash; Fiscal Year: 2010
    ....
  20. Reduction of Amyloid Burden by Antisense APP
    Neelima Chauhan; Fiscal Year: 2005
    ..Significance: Targeting the translation of amyloidogenic APP by antisense synthetic oligodeoxynucleotides may prove to be an effective and safe form of gene therapy for treating familial AD and other genetic diseases. ..
  21. Working memory deficits following brain trauma
    Pramod Dash; Fiscal Year: 2009
    ..An understanding of the mechanisms by which TBI alters dopamine signaling is critical for the development of mechanism-based intelligent pharmacological treatments for working memory deficits for brain trauma patients. ..
  22. The Role of Acetylcholine Dysfunction in Diencephalic Amnesia
    Lisa M Savage; Fiscal Year: 2010
    ..Such experiments are critical to understanding the role of acetylcholine dysfunction in amnesia and thus the development of pharmacotherapeutics. ..
  23. MECHANISMS OF MEMORY DEFICITS FOLLOWING BRAIN INJURY
    Pramod Dash; Fiscal Year: 2006
    ..Furthermore, this project will broaden our understanding of the pathogenesis of neurodegenerative diseases such as stroke and Alzheimer's disease. ..
  24. The Delayed Effects of Phencyclidine: Mechanisms
    Sarah Turgeon; Fiscal Year: 2002
    ..These experiments will begin to identify the mechanisms by which PCP produces schizophrenia-like behaviors in animals, providing insight into potential pathophysiologies underlying schizophrenia in humans. ..
  25. Neurobiology of Spatial Reversal Learning
    Deborah Watson; Fiscal Year: 2008
    ..These goals serve the mission of a variety of NIH agencies (e.g., NICHD, NIMH, NIDA, NIHS, and NIAAA). [unreadable] [unreadable] [unreadable]..
  26. Functions of Dopamine D4 Receptors in Prefrontal Cortex
    Zhen Yan; Fiscal Year: 2007
    ....
  27. Novel Intervention for Colitis
    MICHAEL VITEK; Fiscal Year: 2007
    ..So we propose to directly measure whether COG112 will exacerbate or ameliorate colitis in mouse models. [unreadable] [unreadable] [unreadable]..
  28. Lipidomics Session ISSFAL 2006
    JAMES BRENNA; Fiscal Year: 2006
    ..ISSFAL 2006 is expected to be among the most important international lipid metabolism conferences of the year, and a lipidomics symposium is timely given the increasing progress in this area. [unreadable] [unreadable] [unreadable]..
  29. BASIS OF SYNAPTIC PATHOLOGY IN ALZHEIMERS DISEASE
    Eliezer Masliah; Fiscal Year: 2001
    ..These studies will help to better understand the mechanisms of synaptic pathology in AD and to develop potential neuroprotective agents that will operate by enhancing the GT activity. ..
  30. Apoptosis Execution Pathways in Dopaminergic Cell Death
    Jun Chen; Fiscal Year: 2007
    ..3. Test the hypotheses that Bax is a direct mediator for AIF release, and Bax contributes to dopaminergic cell death by activating both AIF-dependent and caspase-dependent pathways. ..
  31. Measuring Striatal Neurotransmission in Behaving Rats after Experimental TBI
    Amy Wagner; Fiscal Year: 2008
    ..The overarching goal is to gain insight into potential mechanisms of action and efficacy of these interventions on cognition and recovery for the clinical population with TBI. [unreadable] [unreadable] [unreadable]..
  32. Role of D3 dopamine receptor in behavioral sensitization
    NEIL RICHTAND; Fiscal Year: 2007
    ..Significantly, these studies may also elucidate a previously unrecognized mechanism regulating receptor desensitization and trafficking relevant to other receptor systems and pathological conditions. ..
  33. ABCA1 knock-in mouse model to study molecular pathology of Alzheimer's Disease
    Iliya Lefterov; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  34. Early Life Infection, Neuroinflammation, and Memory
    Staci D Bilbo; Fiscal Year: 2010
    ....
  35. Aging and the cholinergic system on attention and timing
    Kevin Pang; Fiscal Year: 2007
    ..This new knowledge will provide directions for the development of treatments. ..
  36. RSA Lecture Series
    Jennifer Thomas; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  37. ANIMAL MODEL OF ALZHEIMERS DISEASE PATHOLOGY
    MICHAEL VITEK; Fiscal Year: 2001
    ..Should this be insufficient to produce PHF/NFT pathology, we will stress these animals in a variety of ways to predispose the formation and detection of PHF/NFT structures (Specific Aim 4). ..
  38. Amygdala Gene Expression: Learning in a Sensitive Period
    GORDON ALFRED BARR; Fiscal Year: 2010
    ..Our preliminary studies show contrasting changes in dopamine markers during and after the sensitive period and follow-up studies implicate further the role of dopamine in the learned preferences to aversive stimuli. ..
  39. ACE Inhibition and Physical Performance in Aged Rats
    Christy Carter; Fiscal Year: 2009
    ..abstract_text> ..
  40. The amygdaloid 5-HT2C receptor in anxiety-like behavior
    Qian Li; Fiscal Year: 2006
    ..Furthermore, the proposed studies have a high potential of leading to the development of novel drugs to treat anxiety disorders. ..
  41. NEUROBIOLOGIC AND COGNITIVE MECHANISMS OF AUTISM
    Nancy Minshew; Fiscal Year: 2006
    ..The Statistical Analysis and Image Processing Core will provide statistical support to the projects and continue statistical research on methods for improving the processing and analysis of fMRI data. ..
  42. CHEMISTRY AND BIOLOGY OF MALONDIALDEHYDE DNA ADDUCTS
    LAWRENCE MARNETT; Fiscal Year: 2004
    ..The results of these experiments will define the chemistry and biology of a family of structurally dynamic lesions in the genome derived from an endogenous metabolic product of lipid oxidation. ..
  43. BRAIN MRI & MRS CHANGES IN FIRST EPISODE SCHIZOPHRENIA
    Jeffrey Lieberman; Fiscal Year: 2004
    ..This study will provide important information about the clinical and neuropathological course of subgroups of schizophrenia and therapeutic strategies for early identification and intervention. ..
  44. General Cognitive /Learning Deficits in Aged Mice
    LOUIS MATZEL; Fiscal Year: 2003
    ..These studies are a critical prelude to future work directed at the elucidation of the brain substrates for age-related declines in general cognitive/learning abilities. ..
  45. Neural Processing of Complex Natural Sounds
    Thane Fremouw; Fiscal Year: 2003
    ..The third aim is to build a framework for understanding how data obtained from these two areas in anesthetized birds can be linked with that obtained in awake birds. ..
  46. Gender Differences in Dopamine Function after TBI
    Amy Wagner; Fiscal Year: 2003
    ....
  47. PAIN REGULATORY SYSTEM DYSFUNCTION IN CHRONIC PAIN
    Stephen Bruehl; Fiscal Year: 2002
    ..Greater pain duration is expected to be associated with smaller changes in the BP/pain relationship in response to opioid blockade. ..
  48. CIRCADIAN RHYTHM ENTRAINMENT
    NORMAN RUBY; Fiscal Year: 2004
    ..We chose to focus on melatonin because its effects on the circadian system of Siberian hamsters suggest a role for this hormone in entrainment. ..
  49. IMPROVED ASSAYS FOR SPECIFICALLY MEASURING COLLAGENASE-3
    MICHAEL VITEK; Fiscal Year: 2004
    ..This "assay" kit can then be used in arthritis and cancer by assessing disease progression. ..
  50. Neprilysin and Abeta-degradation in Alzheimer's disease
    Mark Kindy; Fiscal Year: 2005
    ..The results generated from this study will help us to understand how Abeta peptides are degraded and may provide a unique therapeutic window for the treatment of AD. ..
  51. Efficacy of Hypothermia in Pediatric TBI
    P David Adelson; Fiscal Year: 2004
    ..Parallel clinical specific aims will define the effect of neurotransmitter release in response to treatment with HYPO and the age-related impact of HYPO on early and delayed cell death in children. ..
  52. Triple Transgenic Model of Alzheimer's Disease
    MICHAEL VITEK; Fiscal Year: 2006
    ....
  53. B-Synuclein as a Treatment for Lewy Body Disease
    Eliezer Masliah; Fiscal Year: 2005
    ..abstract_text> ..
  54. Synaptic Alterations in the Cerebral Cortex during Aging
    A Cuello; Fiscal Year: 2005
    ..abstract_text> ..
  55. Antipsychotics: Temporal Effects on Cognitive Function
    Alvin Terry; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  56. Neuroprotective effect of HSP27 in Cerebral Ischemia
    Jun Chen; Fiscal Year: 2010
    ..The in vitro models will complement the in vivo studies by allowing for precise mechanistic studies to be performed. ..
  57. Seasonal Plasticity of Brain and Behavior
    Leah Pyter; Fiscal Year: 2005
    ..3) To determine whether photoperiod also affects non-spatial learning and memory tasks. This research will provide insights into the mechanisms of seasonal plasticity of brain and behavior ..
  58. MECHANISM OF ESTROGEN NEUROPROTECTION IN ALZHEIMERS DISE
    Christian Pike; Fiscal Year: 2003
    ..The applicants anticipate that their novel hypotheses will generate new insight into the ability of estrogen to modulate neuronal viability throughout life, from neural development through age-related neurodegenerative disorders. ..
  59. Pain Regulatory Dysfunction in Chronic Pain
    Stephen Bruehl; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  60. Anger Expression, Opioid Dysfunction, and Chronic Pain
    Stephen Bruehl; Fiscal Year: 2009
    ....
  61. Androgens and Alzheimer's Disease
    Christian Pike; Fiscal Year: 2009
    ..Together, we believe these novel and timely studies will begin an important evaluation of interactions between normal male aging events, neuroprotection, A-beta regulation, and the risk of developing Alzheimer's disease. ..
  62. TRANSGENIC MOUSE MODELS OF ALZHEIMERS DISEASE
    Bruce Lamb; Fiscal Year: 2002
    ....
  63. Voluntary Exercise Therapy after Traumatic Brain Injury
    GRACE GRIESBACH; Fiscal Year: 2006
    ..In order to address these specific aims, I will utilize the lateral fluid-percussion injury model in rats and voluntary running wheel exposure. Protein, gene, histological and behavioral studies will be conducted. ..