discrimination learning

Summary

Summary: Learning that is manifested in the ability to respond differentially to various stimuli.

Top Publications

  1. ncbi Response of neurons in the lateral intraparietal area during a combined visual discrimination reaction time task
    Jamie D Roitman
    Program in Neurobiology and Behavior, Department of Physiology and Biophysics, and Regional Primate Research Center, University of Washington, Seattle, Washington 98195 7290, USA
    J Neurosci 22:9475-89. 2002
  2. ncbi Olfactory discrimination learning increases the survival of adult-born neurons in the olfactory bulb
    Mariana Alonso
    Perception and Memory Laboratory, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2182, Pasteur Institute, 75724 Paris Cedex 15, France
    J Neurosci 26:10508-13. 2006
  3. ncbi Investigating the psychopharmacology of cognitive affective bias in rats using an affective tone discrimination task
    Michael H Anderson
    School of Physiology and Pharmacology, University of Bristol, Medical Sciences Building, University Walk, Bristol, BS8 1TD, UK
    Psychopharmacology (Berl) 226:601-13. 2013
  4. ncbi An EZ-diffusion model for response time and accuracy
    Eric Jan Wagenmakers
    Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands
    Psychon Bull Rev 14:3-22. 2007
  5. ncbi Superior tactile performance and learning in professional pianists: evidence for meta-plasticity in musicians
    Patrick Ragert
    Institute for Neuroinformatics, Theoretical Biology Ruhr University, D 44780 Bochum, Germany
    Eur J Neurosci 19:473-8. 2004
  6. ncbi Aging gracefully: compensatory brain activity in high-performing older adults
    Roberto Cabeza
    Center for Cognitive Neurosciences, Duke University, B203 LSRC Building, Durham, North Carolina 27708, USA
    Neuroimage 17:1394-402. 2002
  7. ncbi Origins of number sense. Large-number discrimination in human infants
    Jennifer S Lipton
    Massachusetts Institute of Technology, MA, USA
    Psychol Sci 14:396-401. 2003
  8. ncbi A new training procedure for studying discrimination learning in fish
    Christian Agrillo
    Department of General Psychology, University of Padua, Italy
    Behav Brain Res 230:343-8. 2012
  9. ncbi Inferential reasoning and modality dependent discrimination learning in olive baboons (Papio hamadryas anubis)
    Vanessa Schmitt
    Cognitive Ethology, German Primate Center, Gottingen, Germany
    J Comp Psychol 123:316-25. 2009
  10. ncbi Number versus continuous quantity in numerosity judgments by fish
    Christian Agrillo
    Department of General Psychology, University of Padova, Italy
    Cognition 119:281-7. 2011

Detail Information

Publications306 found, 100 shown here

  1. ncbi Response of neurons in the lateral intraparietal area during a combined visual discrimination reaction time task
    Jamie D Roitman
    Program in Neurobiology and Behavior, Department of Physiology and Biophysics, and Regional Primate Research Center, University of Washington, Seattle, Washington 98195 7290, USA
    J Neurosci 22:9475-89. 2002
    ..A threshold level of LIP activity appears to mark the completion of the decision process and to govern the tradeoff between accuracy and speed of perception...
  2. ncbi Olfactory discrimination learning increases the survival of adult-born neurons in the olfactory bulb
    Mariana Alonso
    Perception and Memory Laboratory, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2182, Pasteur Institute, 75724 Paris Cedex 15, France
    J Neurosci 26:10508-13. 2006
    ..We report that discrimination learning increases the number of newborn neurons in the adult OB by prolonging their survival...
  3. ncbi Investigating the psychopharmacology of cognitive affective bias in rats using an affective tone discrimination task
    Michael H Anderson
    School of Physiology and Pharmacology, University of Bristol, Medical Sciences Building, University Walk, Bristol, BS8 1TD, UK
    Psychopharmacology (Berl) 226:601-13. 2013
    ..Similar biases have recently been shown in animals, including the rat, providing an opportunity to investigate these processes in non-human species...
  4. ncbi An EZ-diffusion model for response time and accuracy
    Eric Jan Wagenmakers
    Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands
    Psychon Bull Rev 14:3-22. 2007
    ..We studied the performance of the EZ-diffusion model in terms of parameter recovery and robustness against misspecification by using Monte Carlo simulations. The EZ model was also applied to a real-world data set...
  5. ncbi Superior tactile performance and learning in professional pianists: evidence for meta-plasticity in musicians
    Patrick Ragert
    Institute for Neuroinformatics, Theoretical Biology Ruhr University, D 44780 Bochum, Germany
    Eur J Neurosci 19:473-8. 2004
    ..This implies stronger capacities for plastic reorganization and points to enhanced learning abilities implicating a form of meta-plasticity in professional pianists...
  6. ncbi Aging gracefully: compensatory brain activity in high-performing older adults
    Roberto Cabeza
    Center for Cognitive Neurosciences, Duke University, B203 LSRC Building, Durham, North Carolina 27708, USA
    Neuroimage 17:1394-402. 2002
    ....
  7. ncbi Origins of number sense. Large-number discrimination in human infants
    Jennifer S Lipton
    Massachusetts Institute of Technology, MA, USA
    Psychol Sci 14:396-401. 2003
    ....
  8. ncbi A new training procedure for studying discrimination learning in fish
    Christian Agrillo
    Department of General Psychology, University of Padua, Italy
    Behav Brain Res 230:343-8. 2012
    ..Our data indicate a complete overlap of the results obtained using the two different methods. The pros and cons of the new procedure are discussed in respect of traditional associative learning paradigms...
  9. ncbi Inferential reasoning and modality dependent discrimination learning in olive baboons (Papio hamadryas anubis)
    Vanessa Schmitt
    Cognitive Ethology, German Primate Center, Gottingen, Germany
    J Comp Psychol 123:316-25. 2009
    ..Furthermore, they also highlight some important differences in the processing of auditory versus visual information in operant conditioning settings...
  10. ncbi Number versus continuous quantity in numerosity judgments by fish
    Christian Agrillo
    Department of General Psychology, University of Padova, Italy
    Cognition 119:281-7. 2011
    ..Rather, they suggest that availability of multiple information sources may facilitate discrimination learning.
  11. ncbi Contrasting cortical and subcortical activations produced by attentional-set shifting and reversal learning in humans
    R D Rogers
    University of Cambridge and Medical Research Council, United Kingdom
    J Cogn Neurosci 12:142-62. 2000
    ..In this study, we used the same visual discrimination learning paradigm over multidimensional stimuli, and the H215O positron emission tomography (PET) technique, to ..
  12. ncbi Visual recognition: as soon as you know it is there, you know what it is
    Kalanit Grill-Spector
    Department of Psychology, Stanford University, CA, USA
    Psychol Sci 16:152-60. 2005
    ..These findings place powerful constraints on theories of object recognition...
  13. ncbi Rapamycin-sensitive signalling in long-term consolidation of auditory cortex-dependent memory
    Wolfgang Tischmeyer
    Leibniz Institute for Neurobiology, Brenneckestrasse 6, D 39118 Magdeburg, Germany
    Eur J Neurosci 18:942-50. 2003
    ..Whereas one process is required for the initial maintenance of memory for about one day the second one is involved in the regulation of its long-lasting persistence in conditioning to FMs...
  14. ncbi Evidence for counting in insects
    Marie Dacke
    ARC Centre for Excellence in Vision Science, Research School of Biological Sciences, Australian National University, P O Box 475, Canberra, ACT, 2601, Australia
    Anim Cogn 11:683-9. 2008
    ..It appears that bees can navigate to food sources by maintaining a running count of prominent landmarks that are passed en route, provided this number does not exceed four...
  15. pmc Different patterns of human discrimination learning for two interaural cues to sound-source location
    B A Wright
    Department of Communication Sciences and Disorders, and Northwestern University Institute for Neuroscience, Northwestern University, 2299 North Campus Drive, Evanston, IL 60208 3550, USA
    Proc Natl Acad Sci U S A 98:12307-12. 2001
    ..Thus, these data reveal differences in the effect of practice on ILD and ITD discrimination, and provide insight into the encoding of these two cues to sound-source location in humans...
  16. pmc Lesions of the medial striatum in monkeys produce perseverative impairments during reversal learning similar to those produced by lesions of the orbitofrontal cortex
    Hannah F Clarke
    Department of Experimental Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB23EB, United Kingdom
    J Neurosci 28:10972-82. 2008
    ....
  17. pmc Intact performance on feature-ambiguous discriminations in rats with lesions of the perirhinal cortex
    Robert E Clark
    Veterans Affairs Medical Center, San Diego, CA 92161, USA
    Neuron 70:132-40. 2011
    ..In contrast, the perirhinal lesions did impair recognition memory. The findings suggest that the perirhinal cortex is important for memory and not for perceptual functions...
  18. ncbi Neuronal encoding of meaning: establishing category-selective response patterns in the avian 'prefrontal cortex'
    Janina A Kirsch
    Department of Biopsychology, Institute of Cognitive Neuroscience, Faculty of Psychology, Ruhr University Bochum, 44780 Bochum, Germany
    Behav Brain Res 198:214-23. 2009
    ..This backward shift in time resembles response patterns assumed by the temporal difference (TD) model of reinforcement learning, but goes beyond it, since it reflects the neuronal correlate of functional categories...
  19. ncbi Visual discrimination and object categorization in the cichlid Pseudotropheus sp
    V Schluessel
    Institute of Zoology, Rheinische Friedrich Wilhelm Universität Bonn, Poppelsdorfer Schloss, Meckenheimer Allee 169, Bonn, Germany
    Anim Cogn 15:525-37. 2012
    ..During transfer trials involving a previously unknown object, fish were able to discriminate between both the negative and the positive stimulus and the unknown stimulus and responded accordingly...
  20. ncbi Perception of subjective contours in fish
    Valeria Anna Sovrano
    Centre for Mind Brain Sciences, University of Trento, Corso Bettini 31, I 38068 Rovereto TN, Italy
    Perception 38:579-90. 2009
    ..Fish appeared to be able to generalise the orientation discrimination to illusory contours. These results demonstrate that redtail splitfins are capable of perceiving illusory contours...
  21. ncbi Habitual versus goal-directed action control in Parkinson disease
    Sanne de Wit
    Department of Psychology, Amsterdam Center for Study of Adaptive Control in Brain and Behavior Acacia, University of Amsterdam, Roeterstraat 15, 1018 WB, The Netherlands
    J Cogn Neurosci 23:1218-29. 2011
    ..If anything our results suggest a disease severity-dependent deficit in goal-directed behavior. These results are discussed in the context of Parkinson disease and the neurobiology of habitual and goal-directed behavior...
  22. ncbi Do fish count? Spontaneous discrimination of quantity in female mosquitofish
    Christian Agrillo
    Department of General Psychology, University of Padova, Via Venezia 8, 35131, Padua, Italy
    Anim Cogn 11:495-503. 2008
    ....
  23. ncbi The role of the ventromedial prefrontal cortex in abstract state-based inference during decision making in humans
    Alan N Hampton
    Computation and Neural Systems Program, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 26:8360-7. 2006
    ..These results suggest that brain regions, such as the vmPFC, use an abstract model of task structure to guide behavioral choice, computations that may underlie the human capacity for complex social interactions and abstract strategizing...
  24. ncbi Salamanders ( Plethodon cinereus) go for more: rudiments of number in an amphibian
    Claudia Uller
    Institute of Cognitive Science, University of Louisiana at Lafayette, Lafayette, LA 70504 3772, USA
    Anim Cogn 6:105-12. 2003
    ..The findings indicate that salamanders "go for more," just like human babies and monkeys. This rudimentary capacity is a type of numerical discrimination that is spontaneously present in this amphibian...
  25. pmc Paradoxical reversal learning enhancement by stress or prefrontal cortical damage: rescue with BDNF
    Carolyn Graybeal
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Neurosci 14:1507-9. 2011
    ..Stress facilitation of reversal was prevented by BDNF infusion into the vmPFC. These findings suggest a mechanism by which stress-induced vmPFC dysfunction disinhibits learning by alternate (for example, striatal) systems...
  26. ncbi How much does number matter to a monkey (Macaca mulatta)?
    Jessica F Cantlon
    Department of Psychology and Neuroscience, Center for Cognitive Neuroscience, Duke University, Durham, NC 27708 0999, USA
    J Exp Psychol Anim Behav Process 33:32-41. 2007
    ..Contrary to the last-resort hypothesis, all monkeys based their decisions on numerical value when the numerical ratio was favorable...
  27. pmc Knockdown of Nurr1 in the rat hippocampus: implications to spatial discrimination learning and memory
    Wanda I Colón-Cesario
    Department of Biology, University of Puerto Rico, San Juan 00931 3360, Puerto Rico
    Learn Mem 13:734-44. 2006
    ..We postulate that Nurr1 function in the hippocampus is important for normal cognitive processes...
  28. pmc The brain metabolic enhancer methylene blue improves discrimination learning in rats
    Kathryn M Wrubel
    Department of Psychology, University of Texas at Austin, Austin, TX 78712, USA
    Pharmacol Biochem Behav 86:712-7. 2007
    ..post-training MB may improve memory consolidation between days of learning by an induction in the enzyme cytochrome oxidase, leading to increased metabolic capacity in brain regions requiring more energy during discrimination learning.
  29. ncbi Understanding of the concept of numerically "less" by bottlenose dolphins (Tursiops truncatus)
    Kelly Jaakkola
    Dolphin Research Center DRC, Grassy Key, FL 33050, USA
    J Comp Psychol 119:296-303. 2005
    ..Their pattern of errors was consistent with the idea of an underlying analog magnitude representation...
  30. pmc Task-irrelevant learning occurs only when the irrelevant feature is weak
    Yoshiaki Tsushima
    Curr Biol 18:R516-7. 2008
    ..These results provide a parsimonious explanation of why task-irrelevant learning is found in some studies but not others, and could give an important clue to resolving a long-standing controversy...
  31. pmc Changes in S1 neural responses during tactile discrimination learning
    Michael C Wiest
    Department of Neurobiology, Duke University, Durham, North Carolina 27710, USA
    J Neurophysiol 104:300-12. 2010
    ..In summary, the operant behavioral context changes S1 tactile responses even in the absence of tactile discrimination, whereas subsequent width discrimination learning refines the S1 representation of aperture-width.
  32. ncbi Auditory discrimination training for the treatment of tinnitus
    Herta Flor
    Department of Cognitive and Clinical Neuroscience, University of Heidelberg, Central Institute of Mental Health, Quadrat J5, 68159 Mannheim, Germany
    Appl Psychophysiol Biofeedback 29:113-20. 2004
    ..For more substantial changes in multiple variables an extended training period with additional consideration of emotional variables would be necessary. In addition, controls for nonspecific training effects need to be implemented...
  33. ncbi Learning-induced enhancement of feedback inhibitory synaptic transmission
    Inbar Brosh
    Departments of Neurobiology and Biology, Faculty of Sciences, University of Haifa 31905, Israel
    Learn Mem 16:413-6. 2009
    Olfactory-discrimination learning results with a series of intrinsic and excitatory synaptic modifications in piriform cortex pyramidal neurons...
  34. ncbi Revisiting the role of spatial frequencies in the holistic processing of faces
    Olivia S Cheung
    Department of Psychology, Vanderbilt University, Nashville, Tennessee 37203, USA
    J Exp Psychol Hum Percept Perform 34:1327-36. 2008
    ..These results demonstrate that it is necessary to use measures that take response biases into account in order to fully understand the holistic nature of face processing...
  35. ncbi The representations underlying infants' choice of more: object files versus analog magnitudes
    Lisa Feigenson
    New York University, USA
    Psychol Sci 13:150-6. 2002
    ..The infants 'pattern of success and failure supports the hypothesis that they relied on object-file representations, comparing mental models via total volume or surface area rather than via one-to-one correspondence between objectfiles...
  36. ncbi Template-matching describes visual pattern-recognition tasks in the weakly electric fish Gnathonemus petersii
    Stefan Schuster
    Institut für Biologie I, Hauptstrasse 1, Albert Ludwigs Universitat Freiburg, D 79104 Freiburg, Germany
    J Exp Biol 205:549-57. 2002
    ....
  37. pmc Ontogeny of numerical abilities in fish
    Angelo Bisazza
    Department of General Psychology, University of Padova, Padova, Italy
    PLoS ONE 5:e15516. 2010
    ....
  38. ncbi Object categorization: reversals and explanations of the basic-level advantage
    Timothy T Rogers
    Department of Psychology, University of Wisconsin Madison, Madison, WI 15206, US
    J Exp Psychol Gen 136:451-69. 2007
    ..Implications for theories of visual object recognition are discussed...
  39. ncbi Transfer of spatial behavior between different environments: implications for theories of spatial learning and for the role of the hippocampus in spatial learning
    John M Pearce
    School of Psychology, Cardiff University, Cardiff CF10 3YG, Wales, UK
    J Exp Psychol Anim Behav Process 30:135-47. 2004
    ..The results suggest that rats did not use the overall shape of the arena to locate the platform but relied on more local cues and that the hippocampus plays a role in navigation based on these cues...
  40. pmc Large number discrimination by mosquitofish
    Christian Agrillo
    Department of General Psychology, University of Padova, Padova, Italy
    PLoS ONE 5:e15232. 2010
    ..The mechanisms underlying the discrimination of small quantities (<4) were recently investigated while, to date, no study has examined the discrimination of large numerosities in fish...
  41. ncbi Discrimination of small numerosities in young chicks
    Rosa Rugani
    Department of General Psychology, University of Padova, Padova, Italy
    J Exp Psychol Anim Behav Process 34:388-99. 2008
    ..This adds to increasing evidence for discrimination of small numerosities of up to three elements in human infants and nonhuman animals...
  42. pmc Neural correlates of perceptual learning in a sensory-motor, but not a sensory, cortical area
    Chi Tat Law
    Department of Neuroscience, 116 Johnson Pavilion, 3610 Hamilton Walk, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6074, USA
    Nat Neurosci 11:505-13. 2008
    ..Thus, for this task, perceptual learning does not appear to involve improvements in how sensory information is represented in the brain, but rather how the sensory representation is interpreted to form the decision that guides behavior...
  43. ncbi Dogs recall their owner's face upon hearing the owner's voice
    Ikuma Adachi
    Department of Psychology, Graduate School of Letters, Kyoto University, Yoshida Honmachi, Sakyo, Kyoto, 606 8501, Japan
    Anim Cogn 10:17-21. 2007
    ..However, our subjects looked longer at the owner's face in Incongruent condition than in Congruent condition. This may indicate that dogs may have predicted that it should not be the owner when they heard the unfamiliar person's voice...
  44. ncbi Perceptual learning: a case for early selection
    Manfred Fahle
    Institute of Brain Research, Human Neurobiology, University of Bremen, Germany
    J Vis 4:879-90. 2004
    ..An alternative explanation based on late selection is discussed...
  45. ncbi Holistic processing is not correlated with face-identification accuracy
    Yaroslav Konar
    Department of Psychology, Neuroscience, and Behaviour, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    Psychol Sci 21:38-43. 2010
    ..These findings are inconsistent with the claim that holistic processing, as indexed by the composite face effect, significantly influences accuracy in a face-identification task...
  46. pmc Differential engagement of the ventromedial prefrontal cortex by goal-directed and habitual behavior toward food pictures in humans
    Sanne de Wit
    Amsterdam Center for the Study of Adaptive Control in Brain and Behavior Acacia, Department of Psychology, University of Amsterdam, 1018 WB Amsterdam, The Netherlands
    J Neurosci 29:11330-8. 2009
    ..We can therefore exclude a purely Pavlovian account of ventromedial prefrontal function and unequivocally demonstrate its involvement in the acquisition as well as deployment of goal-directed knowledge...
  47. ncbi Quantitative competencies in infancy
    Sara Cordes
    Duke University Center for Cognitive Neuroscience, Durham, NC 27708, USA
    Dev Sci 11:803-8. 2008
    ..The preverbal infant may be better able to extract numerosity than continuous variables from arrays of discrete items...
  48. ncbi Elemental representations of stimuli in associative learning
    Justin A Harris
    School of Psychology, University of Sydney, Sydney, NSW 2006, Australia
    Psychol Rev 113:584-605. 2006
    ..A. Rescorla (2000, 2001, 2002b) concerning the way that stimuli with different conditioning histories acquire associative strength when conditioned in compound...
  49. ncbi Reduced orbitofrontal-striatal activity on a reversal learning task in obsessive-compulsive disorder
    Peter L Remijnse
    Department of Psychiatry, VU University Medical Center, Graduate School of Neurosciences, and Outpatient Academic Clinic for Anxiety Disorders, GGZ Buitenamstel, Amsterdam, The Netherlands
    Arch Gen Psychiatry 63:1225-36. 2006
    ..However, the engagement of this neural loop in OCD has not been tested directly in a cognitive activation imaging paradigm so far...
  50. pmc Role of the dorsomedial striatum in behavioral flexibility for response and visual cue discrimination learning
    Michael E Ragozzino
    Department of Psychology, University of Illinois at Chicago, 60607, USA
    Behav Neurosci 116:105-15. 2002
    ..Thus, specific circuits in the prefrontal cortex and striatum may interact to enable behavioral flexibility, but each region may contribute to distinct processes that facilitate strategy switching...
  51. ncbi Object detection and basic-level categorization: sometimes you know it is there before you know what it is
    Michael L Mack
    Vanderbilt University, Nashville, Tennessee, USA
    Psychon Bull Rev 15:28-35. 2008
    ..The time course of object detection and object categorization can be selectively manipulated. They are not intrinsically linked. As soon as you know an object is there, you do not necessarily know what it is...
  52. ncbi Similarity and the development of rules
    D Gentner
    Department of Psychology, Northwestern University, Evanston, IL 60208, USA
    Cognition 65:263-97. 1998
    ....
  53. ncbi Discriminative whisking in the head-fixed rat: optoelectronic monitoring during tactile detection and discrimination tasks
    M A Harvey
    Biopsychology Program, Hunter College, CUNY, New York, NY 10021, USA
    Somatosens Mot Res 18:211-22. 2001
    ..We conclude that the functional contribution of the macrovibrissae will vary with the nature of the task and the conditions of testing...
  54. ncbi Discrimination learning of amplitude modulated tones in Mongolian gerbils
    H Schulze
    Leibniz Institute for Neurobiology, Magdeburg, Germany
    Neurosci Lett 261:13-6. 1999
    b>Discrimination learning of 100% sinusoidal amplitude modulated tones (AM) was investigated in adult Mongolian gerbils using a footshock motivated shuttle box avoidance go/no go paradigm...
  55. pmc Specificity of perceptual learning increases with increased training
    Pamela E Jeter
    Memory, Attention and Perception Laboratory MAP, Department of Cognitive Sciences, University of California, Irvine, CA 92697, USA
    Vision Res 50:1928-40. 2010
    ..Brief training shows the best performance at the point of transfer. These results for orientation-location transfer have both theoretical and practical implications for understanding perceptual expertise...
  56. pmc Euthymic patients with bipolar disorder show decreased reward learning in a probabilistic reward task
    Diego A Pizzagalli
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Biol Psychiatry 64:162-8. 2008
    ..Our goal was to test the hypothesis that BPD is characterized by impairments in adjusting behavior as a function of prior reinforcement history, particularly in the presence of residual anhedonic symptoms...
  57. pmc Empty sets as part of the numerical continuum: conceptual precursors to the zero concept in rhesus monkeys
    Dustin J Merritt
    Center for Cognitive Neuroscience, Duke University, Durham, NC 27708 0999, USA
    J Exp Psychol Gen 138:258-69. 2009
    ..All monkeys successfully matched and ordered the empty sets without any training. Accuracy showed distance effects, indicating that they treated empty sets as values on a numerical continuum...
  58. pmc Choice ball: a response interface for two-choice psychometric discrimination in head-fixed mice
    Joshua I Sanders
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA
    J Neurophysiol 108:3416-23. 2012
    ..The choice ball enables head-fixed 2AFC paradigms, facilitating the circuit-level analysis of sensory processing, decision making, and motor control in mice...
  59. pmc Auditory discrimination learning and knowledge transfer in mice depends on task difficulty
    Simone Kurt
    Institute of Neurobiology, University of Ulm, D 89081 Ulm, Germany
    Proc Natl Acad Sci U S A 107:8481-5. 2010
    Mice reproduce interesting effects in auditory discrimination learning and knowledge transfer discussed in human studies: (i) the advantage in the transfer from a hard to an easy task by benefits from transfer of procedural knowledge and ..
  60. ncbi Deficits in experience-dependent cortical plasticity and sensory-discrimination learning in presymptomatic Huntington's disease mice
    Nektarios K Mazarakis
    University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, United Kingdom
    J Neurosci 25:3059-66. 2005
    ..We report here that motor presymptomatic R6/1 HD mice show a severe impairment of somatosensory-discrimination learning ability in a behavioral task that depends heavily on the barrel cortex...
  61. ncbi The reviewing of object files: object-specific integration of information
    D Kahneman
    University of California, Berkeley
    Cogn Psychol 24:175-219. 1992
    ..In the absence of an object link, the reviewing item is selected at random. We develop the concept of an object file as a temporary episodic representation, within which successive states of an object are linked and integrated...
  62. pmc Dissociable effects of subtotal lesions within the macaque orbital prefrontal cortex on reward-guided behavior
    Peter H Rudebeck
    Section on Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Neurosci 31:10569-78. 2011
    ..Our data indicate that anatomically defined subregions within macaque PFo make dissociable contributions to reward-guided behavior...
  63. ncbi Neural correlates of evidence accumulation in a perceptual decision task
    Taosheng Liu
    Dept of Psychology, Michigan State Univ, East Lansing, MI 48824, USA
    J Neurophysiol 106:2383-98. 2011
    ..Instead, the neural system might accumulate evidence for particular stimulus features relevant to a perceptual task...
  64. pmc Discrimination learning, reversal, and set-shifting in first-episode schizophrenia: stability over six years and specific associations with medication type and disorganization syndrome
    Verity C Leeson
    UCL Institute of Neurology, London, United Kingdom Imperial College Faculty of Medicine, London, United Kingdom
    Biol Psychiatry 66:586-93. 2009
    ..Limited evidence suggests that attentional set-shifting deteriorates over time in schizophrenia. We tested this hypothesis and examined the specificity of learning impairments identified by this task...
  65. ncbi How object-specific are object files? Evidence for integration by location
    Wessel O van Dam
    Leiden University Institute for Psychological Research and Leiden Institute for Brain and Cognition, Leiden, The Netherlands
    J Exp Psychol Hum Percept Perform 36:1184-92. 2010
    ..Taken together, these findings suggest that spatial overlap of visual features is a sufficient criterion for integrating them into the same object file...
  66. ncbi The capacity of visual short-term memory is set both by visual information load and by number of objects
    G A Alvarez
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Psychol Sci 15:106-11. 2004
    ..Thus, both the visual information load and number of objects impose capacity limits on visual short-term memory...
  67. pmc Dopaminergic modulation of auditory cortex-dependent memory consolidation through mTOR
    Horst Schicknick
    Leibniz Institute for Neurobiology, D 39118 Magdeburg, Germany
    Cereb Cortex 18:2646-58. 2008
    Previous studies in the auditory cortex of Mongolian gerbils on discrimination learning of the direction of frequency-modulated tones (FMs) revealed that long-term memory formation involves activation of the dopaminergic system, activity ..
  68. pmc Inhibition of return and object-based attentional selection
    Alexandra List
    Department of Psychology, University of California, Berkeley, USA
    J Exp Psychol Hum Percept Perform 33:1322-34. 2007
    ..These findings also have implications for the search facilitator role that IOR is purported to play in the guidance of visual attention...
  69. ncbi Olfactory-learning abilities are correlated with the rate by which intrinsic neuronal excitability is modulated in the piriform cortex
    Sivan I Cohen-Matsliah
    Departments of Neurobiology and Biology, Faculty of Sciences, Haifa University, Haifa, Israel
    Eur J Neurosci 30:1339-48. 2009
    ..We suggest that the rate at which neuronal excitability is modified during learning may affect the behavioral flexibility of the animal...
  70. ncbi A critical time window for the recruitment of bulbar newborn neurons by olfactory discrimination learning
    Laure Belnoue
    INSERM U862, Magendie Neurocenter, Neurogenesis and Pathophysiology Group, Bordeaux F 33077, France
    J Neurosci 31:1010-6. 2011
    ..Our data thus show that newborn neurons are indeed involved in odor processing and that their recruitment is age- and memory process-dependent...
  71. ncbi Dopamine modulates memory consolidation of discrimination learning in the auditory cortex
    Horst Schicknick
    Special Lab Molecular Biological Techniques, Leibniz Institute for Neurobiology, Brenneckestrasse 6, D 39118 Magdeburg, Germany
    Eur J Neurosci 35:763-74. 2012
    ..To test this hypothesis, we studied frequency-modulated tone discrimination learning of gerbils in a shuttle box GO/NO-GO procedure following differential treatments...
  72. ncbi Why does selective attention to parts fail in face processing?
    Jennifer J Richler
    Department of Psychology, Vanderbilt University, Wilson Hall, Nashville, TN 37203, USA
    J Exp Psychol Learn Mem Cogn 34:1356-68. 2008
    ..Together, these results cannot be accounted for by current perceptual or decisional accounts of holistic processing and suggest the existence of an attention-dependent mechanism that can integrate spatially separated face parts...
  73. ncbi Auditory aversive learning increases discrimination thresholds
    Jennifer Resnik
    Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
    Nat Neurosci 14:791-6. 2011
    ..We suggest that for risk- or loss-related stimuli, less specificity could be a benefit, as it invokes the same mechanisms that respond quickly and efficiently in the face of danger...
  74. ncbi Blockade of NMDA GluN2B receptors selectively impairs behavioral flexibility but not initial discrimination learning
    Gemma L Dalton
    Department of Psychology and Brain Research Centre, University of British Columbia, Vancouver, BC, Canada
    Psychopharmacology (Berl) 216:525-35. 2011
    ....
  75. pmc Separate encoding of identity and similarity of complex familiar odors in piriform cortex
    Mikiko Kadohisa
    Department of Zoology, University of Oklahoma, Norman, OK 73019, USA
    Proc Natl Acad Sci U S A 103:15206-11. 2006
    ....
  76. ncbi Discrimination learning with light stimuli in restrained American lobster
    Yusuke Tomina
    Animal Behavior and Intelligence, Graduate School of Life Science, Hokkaido University, Sapporo 060 0810, Japan
    Behav Brain Res 229:91-105. 2012
    Operant discrimination learning has been extensively utilized in the study on the perceptual ability of animals and their higher order brain functions...
  77. ncbi Further analysis of the effects of immunotoxic lesions of the basal nucleus of Meynert reveals substantial impairment on visual discrimination learning in monkeys
    Rosalind M Ridley
    Department of Experimental Psychology, Downing Street, Cambridge CB2 3EB, UK
    Brain Res Bull 65:433-42. 2005
    ..that the cholinergic projection from the NBM to the major target area of neocortex involved in visual discrimination learning, i.e...
  78. ncbi Top-down and bottom-up sequential modulations of congruency effects
    Wim Notebaert
    Department of Experimental Psychology, Ghent University, Henri Dunantlaan 2, 9000 Ghent, Belgium
    Psychon Bull Rev 13:112-7. 2006
    ..Bottom-up modulation is observed for both RSIs. This finding demonstrates that two different sources simultaneously reduce congruency effects after incongruent trials...
  79. ncbi Separate geometric and non-geometric modules for spatial reorientation: evidence from a lopsided animal brain
    Giorgio Vallortigara
    University of Trieste, Trieste, Italy
    J Cogn Neurosci 16:390-400. 2004
    ....
  80. ncbi Quantity discrimination in female mosquitofish
    Christian Agrillo
    Department of General Psychology, University of Padova, Via Venezia 8, 35131, Padova, Italy
    Anim Cogn 10:63-70. 2007
    ....
  81. pmc Complete transfer of perceptual learning across retinal locations enabled by double training
    Lu Qi Xiao
    State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China
    Curr Biol 18:1922-6. 2008
    ....
  82. pmc Seeing the mean: ensemble coding for sets of faces
    Jason Haberman
    Center for Mind and Brain and Department of Psychology, University of California, Davis, CA 95616, USA
    J Exp Psychol Hum Percept Perform 35:718-34. 2009
    ..These findings support the hypothesis that ensemble coding occurs extremely fast at multiple levels of visual analysis...
  83. pmc Single-unit activity in piriform cortex during slow-wave state is shaped by recent odor experience
    Donald A Wilson
    Nathan Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    J Neurosci 30:1760-5. 2010
    ..The results demonstrate that piriform cortical activity during slow-wave state is shaped by recent odor experience, which could contribute to odor memory consolidation...
  84. ncbi Superior visual search in autism
    M A O'Riordan
    Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom
    J Exp Psychol Hum Percept Perform 27:719-30. 2001
    ..Unique item detection in autism is discussed in the light of mechanisms proposed to be involved in normal visual search performance...
  85. pmc Impaired discrimination learning in mice lacking the NMDA receptor NR2A subunit
    Jonathan L Brigman
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, Rockville, Maryland 20852, USA
    Learn Mem 15:50-4. 2008
    ..NR2A KO mice exhibited significantly retarded discrimination learning. Performance on reversal was impaired in NR2A KO mice during the learning phase of the task; with no ..
  86. pmc Perirhinal cortex resolves feature ambiguity in configural object recognition and perceptual oddity tasks
    Susan J Bartko
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    Learn Mem 14:821-32. 2007
    ..These findings support the idea that PRh contains conjunctive representations for the resolution of feature ambiguity and that these representations underlie a dual role for PRh in memory and perception...
  87. ncbi Small and large number processing in infants and toddlers with Williams syndrome
    Jo Van Herwegen
    Neurocognitive Development Unit, UCL Institute of Child Health, UK
    Dev Sci 11:637-43. 2008
    ..Finally, we argue that individual differences in large number processing in infancy are more likely than small number processing to be predictive of later development of numerical cognition...
  88. ncbi Temporal limitation of Navon effect on face recognition
    Peter J Hills
    School of Psychology, Tower Building, Cardiff University, Park Place, Cardiff, Wales, UK
    Percept Mot Skills 104:501-9. 2007
    ..In Exp. 2 analysis of undergraduates' responses (9 men, 20 women, M age =19, selected by convenience) showed the decrease in the Navon effect could be prevented by alternating the Navon task with the face recognition task...
  89. ncbi Developmental change in the acuity of the "Number Sense": The Approximate Number System in 3-, 4-, 5-, and 6-year-olds and adults
    Justin Halberda
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
    Dev Psychol 44:1457-65. 2008
    ..We show that the resolution of this system continues to increase throughout childhood, with adultlike levels of acuity attained surprisingly late in development...
  90. ncbi Neonatal choline supplementation ameliorates the effects of prenatal alcohol exposure on a discrimination learning task in rats
    J D Thomas
    Center for Behavioral Teratology, San Diego State University, Suite 209, 6363 Alvarado Ct, San Diego, CA 92120, USA
    Neurotoxicol Teratol 22:703-11. 2000
    ..These data suggest that early dietary interventions may reduce the severity of fetal alcohol effects...
  91. ncbi Effect of auditory cortex lesions on the discrimination of frequency-modulated tones in rats
    Natalia Rybalko
    Department of Auditory Neuroscience, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague, Czech Republic
    Eur J Neurosci 23:1614-22. 2006
    ..The results demonstrate a hemispheric asymmetry of the rat AC in the recognition of FM stimuli and indicate the dominance of the right AC in the discrimination of the direction of frequency modulation...
  92. ncbi A molecular mechanism for stabilization of learning-induced synaptic modifications
    Elizabeth M Quinlan
    Department of Biology, Neuroscience and Cognitive Sciences Program, University of Maryland, College Park, 20742, USA
    Neuron 41:185-92. 2004
    ....
  93. ncbi Discrimination learning in Rora(sg) and Grid2(ho) mutant mice
    R Lalonde
    Centre Hospitalier de l Université de Montréal St Luc, Unité de Recherche en Sciences Neurologiques, 1058 St Denis St, Montreal, Que H2X3J4, Canada
    Neurobiol Learn Mem 90:472-4. 2008
    ..with more severe granule cell degeneration as well as Purkinle cell atrophy for left-right and dark-light discrimination learning tasks in a water-filled T-maze...
  94. ncbi The role of the hippocampus in memory for the temporal order of a sequence of odors
    Raymond P Kesner
    Department of Psychology, University of Utah, Salt Lake City 84112, USA
    Behav Neurosci 116:286-90. 2002
    ..However, the HIP group could discriminate between the odors. The data suggest that the hippocampus is involved in separating sensory events in time so that I event can be remembered separately from another event...
  95. pmc The time course of neural changes underlying auditory perceptual learning
    Mercedes Atienza
    Laboratory of Sleep and Cognition, Seville 41005, Spain
    Learn Mem 9:138-50. 2002
    ....
  96. ncbi Scotopic colour vision in nocturnal hawkmoths
    Almut Kelber
    Department of Cell and Organism Biology, Vision Group, Lund University, Helgonavagen 3, S 22362 Lund, Sweden
    Nature 419:922-5. 2002
    ..Taken together, our results show that colour vision occurs at nocturnal intensities in a biologically relevant context...
  97. ncbi Dissociation of explicit and implicit timing in repetitive tapping and drawing movements
    Howard N Zelaznik
    Department of Health and Kinesiology, Purdue University, West Lafayette, Indiana 47907, USA
    J Exp Psychol Hum Percept Perform 28:575-88. 2002
    ..However, timing variability of these 3 tasks was not correlated with timing variability of continuous circle drawing. These results support the hypothesized distinction between explicit and implicit temporal representations...
  98. ncbi Feature detection and letter identification
    Denis G Pelli
    Institute for Sensory Research, Syracuse University, Syracuse, New York, NY 13210, USA
    Vision Res 46:4646-74. 2006
    ..This, and the surprisingly fixed ratio of detection and identification thresholds, indicate that identifying a letter is mediated by detection of about 7 visual features...
  99. ncbi Haptic classification of common objects: knowledge-driven exploration
    S J Lederman
    Department of Psychology, Queen's University, Kingston, Ontario, Canada
    Cogn Psychol 22:421-59. 1990
    ....
  100. ncbi Early and late components of visual categorization: an event-related potential study
    A Antal
    Department of Physiology, Albert Szent Gyorgyi Medical University, POB 1192, H 6720, Szeged, Hungary
    Brain Res Cogn Brain Res 9:117-9. 2000
    ..In the DT, spatial frequency gratings evoked only a short-duration difference N1 at the frontal sites. Our results suggest that N1 may be related to higher-level categorization processes...
  101. pmc Conditions for facelike expertise with objects: becoming a Ziggerin expert--but which type?
    Alan C N Wong
    The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Psychol Sci 20:1108-17. 2009
    ..Rather, qualitatively different types of expertise with objects of a given geometry can arise depending on the type of training...

Research Grants63

  1. SENSORY CODING IN TASTE
    John D Boughter; Fiscal Year: 2013
    ..The goal of this research is to elucidate pathways in the brain that link taste to feeding and reward. ..
  2. Mechanisms of Avian Visual Perception, Cognition, and Action
    Robert G Cook; Fiscal Year: 2013
    ..Using our well-developed psychophysical techniques based on discrimination learning, we propose to evaluate this problem by examining in how starlings and pigeons process visual stimuli in ..
  3. GUIDING VISUAL ATTENTION TO ENHANCE DISCRIMINATION LEARNING
    Michael T Carlin; Fiscal Year: 2011
    ..Existing literature, though limited, implies that these populations would be expected to perform quite differently on these tasks. Further, our use of reaction time (RT) and eye-tracking measures of ..
  4. The Role of Basal Forebrain in Mild Cognitive Impairment
    CANDI LASARGE JENDRO; Fiscal Year: 2010
    ..basal forebrain cholinergic and/or GABAergic afferents to hippocampus are indeed critical to olfactory discrimination learning and spatial learning, both of which are compromised in aging (Specific Aim 3)...
  5. Neural Basis of Sensory Discrimination Learning
    DAVID TRUMBULL BLAKE; Fiscal Year: 2010
    ..However, this is a basic science application, and so direct applicability to public health will depend upon follow-up applied studies. ..
  6. Behavioral Toxicity of Chronic Alcohol Drinking in Peri-Adolescent Monkeys
    Michael A Taffe; Fiscal Year: 2012
    ..Alcohol-exposed animals appeared unimpaired on discrimination learning and long-term memory tests suggesting an effect which may be selective for specific cognitive domains...
  7. Hippocampal neurogenesis, pattern separation &age-related cognitive impairments.
    Rene Hen; Fiscal Year: 2013
    ..We have shown that hippocampal neurogenesis is required for specific forms of learning such as context discrimination learning that may involve pattern separation (Sahay et al., 2011a)...
  8. Atypical Effects of Reinforcement Procedures in ASD
    William J McIlvane; Fiscal Year: 2013
    ..of effective reinforcer deliveries will correlate positivel with performance on procedures that require discrimination learning, and (2) Results of certain psychobiological measures will differentiate children who do and do not show ..
  9. Temporal Dynamics of Neural Plasticity During Auditory Discrimination Learning
    DEREK G ZARAZA; Fiscal Year: 2010
    ..Here we application research on a novel animal system that has great promise to give insights into how auditory memories are formed and maintained. ..
  10. TEMPORAL DISCRIMINATION LEARNING
    Russell Church; Fiscal Year: 2007
    ..An understanding of the mechanisms underlying timed performance may contribute to an understanding of these effects. ..
  11. CLINICAL RESERCH CENTER FOR COMMUNICATIVE DISORDERS
    Robert Ruben; Fiscal Year: 1991
    ..Project III will prospectively relate early auditory discrimination learning capacities to the development of normal and abnormal language...
  12. OPERANT TESTING OF ACUITY IN TODDLERS
    Wendy Marsh Tootle; Fiscal Year: 1990
    ..Principles of discrimination learning and operant reinforcement have been successfully used to test vision in animals and young humans...
  13. CONTEXTUAL CONTROL OF OPIATE EFFECTS
    TORBJORN JARBE; Fiscal Year: 1999
    ..The analysis makes use of the powerful tool of drug discrimination learning applied to a classical conditioning procedure (discriminated conditioned taste aversion), as well as to ..
  14. Learning and Representation in Auditory Perception
    Eduardo Mercado; Fiscal Year: 2007
    ..The specific aims of the research project are to model changes in cortical encoding that are induced by discrimination learning, and to test whether the discriminability of complex sounds can be increased through extended training or ..
  15. CONDITIONAL DISCRIMINATION LEARNING
    Thomas Zentall; Fiscal Year: 1980
    Conditional discrimination learning by pigeons traditionally has been thought to involve acquisition of a series of stimulus-response chains of sample-specific rules of the form: respond to B after having been stimulated by A, and ..
  16. A1 neural basis of frequency discrimination learning
    David Blake; Fiscal Year: 2005
    ..abstract_text> ..
  17. Disinhibition and risk for early substance use
    Craig Colder; Fiscal Year: 2002
    ..continuous performance task, (2) Behavior as assessed by deficits in passive avoidance during a go/no-go discrimination learning task, and (3) Attention as assessed by a bias to attend to reward relative to punishment cues exhibited ..
  18. BEHAVIORALLY INDUCED NEUROCHEMICAL PLASTICITY
    Christine Gall; Fiscal Year: 2001
    ..Behavioral groups include rats at different stages in olfactory discrimination learning, recently engaged in copulation, or having received an IP saline injection; analysis will focus on ..
  19. ORDINAL RELATIONS AND TRANSITIVITY IN MENTAL RETARDATION
    Robert Stromer; Fiscal Year: 1993
    ..for a three-year study of stimulus control and transitive processes in mentally retarded individuals' discrimination learning. The project seeks to clarify learning processes involved in the formation of stimulus classes defined by ..
  20. FACTORS IN VISUAL/GRAPHIC SYMBOL ACQUISITION AND USE
    ROSE SEVCIK; Fiscal Year: 2001
    ..In turn, these findings will permit the design, development, and implementation of more efficient and effective language interventions. ..
  21. STIMULUS-REINFORCER RELATIONS--CONDITIONAL BEHAVIOR
    William McIlvane; Fiscal Year: 1990
    This application seeks support for a three-year study of procedures that may enhance discrimination learning and retention in mentally retarded individuals...
  22. BOLD fMRI in MR research to map learning histories
    MICHAEL SCHLUND; Fiscal Year: 2004
    ..presents data from a preliminary investigation using BOLD fMRI to examine relations between a history of discrimination learning and neural patterns of activation in a small number of adult human subjects...
  23. ASSOCIATIVE UNIT IN CONDITIONAL DISCRIMINATION
    Ben Williams; Fiscal Year: 1980
    The research will investigate conditional discrimination learning in animal subjects...
  24. Responses and Equivalence Classes
    Peter Urcuioli; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  25. Pharmacotherapy of Cannabinoid Withdrawal: Pre-Clinical Studies
    Lance R McMahon; Fiscal Year: 2010
    ..Collectively, these specific aims provide a framework for developing novel pharmacotherapies of marijuana withdrawal that could markedly decrease marijuana use and dependence. ..
  26. Memory Processing in Primates and Avians
    Anthony A Wright; Fiscal Year: 2010
    ..g., neurophysiological) on how memory works. ..
  27. Drug discrimination and THC withdrawal in monkeys
    LANCE MCMAHON; Fiscal Year: 2005
    ..abstract_text> ..
  28. Learning Processes in Matching-to-Sample by Pigeons
    Anthony Wright; Fiscal Year: 2005
    ..This research will extend our knowledge of how tasks are learned, problems solved, and conditions that lead to either higher-order concept learning or stimulus-specific learning. ..
  29. MEMORY PROCEDURES FOR DRUG ASSESSMENTS
    Anthony Wright; Fiscal Year: 2001
    ..Understanding how memory works and the mechanisms of drugs and drug abuse on memory is necessary for any effective treatment regime. ..
  30. Perceptual and Decisional Processes in Categorization
    W Maddox; Fiscal Year: 2006
    ..Project 4 extends the studies in Project I - 3 to an explicit decision criterion task where observers adjust an observable decision criterion on each trial. These data are useful for testing learning models. ..
  31. Processes of Discrimination and Attention
    DONALD BLOUGH; Fiscal Year: 2008
    ..The work stresses the collection of quantitative data suitable for mathematical modeling; an exemplar model of discrimination and memory is used to predict key results. ..
  32. PERCEPTUAL BASES OF VISUAL CONCEPTS
    EDWARD WASSERMAN; Fiscal Year: 2008
    ..The results could also promote the behavioral analysis of discrimination and generalization processes in learning-disabled or language-deficient humans. [unreadable] [unreadable]..
  33. PERCEPTUAL BASES OF VISUAL CONCEPTS
    Edward A Wasserman; Fiscal Year: 2010
    ..Our results should also advance our understanding of how the visual system develops and how to promote its regeneration after disease or injury. ..
  34. Linking Affect to Action: Critical Contributions of the Orbitofrontal Cortex
    Geoffrey Schoenbaum; Fiscal Year: 2006
    ..The participation of minorities and women has been emphasized at each level (organizers, speakers, students). Thus the conference will address important scientific, social, and educational issues. [unreadable] [unreadable] [unreadable]..
  35. Errors and Expectancies in OFC and VTA and their Roles in Associative Learning
    GEOFFREY M SCHOENBAUM; Fiscal Year: 2010
    ..This proposal will test this hypothesis, using inactivation and single-unit recording to ask how OFC is involved learning and in the calculation of prediction errors in dopaminergic VTA neurons during Pavlovian blocking. ..
  36. Theoretical analysis of the effects of aging on memory and reaction time
    Roger Ratcliff; Fiscal Year: 2010
    ....
  37. Egocentric reference frames in memory
    David Waller; Fiscal Year: 2005
    ..Findings may also lead to ways of improving spatial abilities in the general population. ..
  38. Acquired Appetitive Properties of Nicotine
    Rick A Bevins; Fiscal Year: 2010
    ....
  39. Design and Development of Pharmacotherapies for Treating Stimulant Abuse
    Frank Ivy Carroll; Fiscal Year: 2010
    ..3) To continue on a limited basis our development of selected 3-phenyltropane analogs as second-generation pharmacotherapies to treat cocaine addiction. ..
  40. Nicotinic-Antipsychotic Drug Interactions and Cognition
    Edward Levin; Fiscal Year: 2006
    ..abstract_text> ..
  41. Striatal Contributions to Category Learning
    J Vincent Filoteo; Fiscal Year: 2005
    ..Further, quantitative models will be applied to the data of PD patients and controls in order to determine more precisely the nature of any observed category learning deficits in the PD patients. ..
  42. Marine Toxin Impacts on Neurobehavioral Function
    Edward Levin; Fiscal Year: 2003
    ..The forum will provide an opportunity for methodological and theoretical issues to be integrated in the context of each talk as well as in a discussion session at the end of the symposium. ..
  43. RETRIEVAL PROCESSES IN MEMORY
    Roger Ratcliff; Fiscal Year: 2004
    ..Reaction time models especially might lead to diagnostic techniques that are non-invasive and relatively inexpensive. ..
  44. SEX DIFFERENCES IN NICOTINE REINFORCEMENT: HUMAN/ANIMAL
    Kenneth Perkins; Fiscal Year: 2003
    ....
  45. INDIVIDUAL VARIATION IN NICOTINE SENSITIVITY IN HUMANS
    Kenneth Perkins; Fiscal Year: 2003
    ..e., in nicotine-naive individuals). Results will provide directions for future research on vulnerability to tobacco dependence and for targeted efforts to prevent smoking onset. ..
  46. LEARNING ON BASIC AUDITORY TASKS
    BEVERLY WRIGHT; Fiscal Year: 2009
    ..Millions of people in the United States have a communication disorder, the majority of whom could benefit from perceptual training. Thus, the application of the proposed research could markedly improve public health. ..
  47. Ethanol Discrimination in Transgenic Mice
    KEITH SHELTON; Fiscal Year: 2002
    ..background to the ethanol's discriminative ctimnlnc effects. ..
  48. Reference-dose method and cocaine-conditioned choice
    RICK BEVINS; Fiscal Year: 2006
    ..That research could translate into more effective intervention strategies. ..
  49. Behavioral Genetics and Toxic Response
    Edward Levin; Fiscal Year: 2002
    ....
  50. Function of FMRP in the Mouse Olfactory System
    John Larson; Fiscal Year: 2007
    ..Such new information would be vital for evaluating novel treatment strategies for a class of developmental disabilities. [unreadable] [unreadable]..
  51. Adolescence: A Sensitive Period for Nicotine Addiction
    Edward Levin; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  52. US Specific and General Processes in Pavlovian Learning
    ANDREW DELAMATER; Fiscal Year: 2006
    ..More globally, it is hoped that these studies will provide a much firmer basis upon which to think about the cognitive and motivational foundations of learning. ..
  53. Affect, Context, and Placebo Responses to Nicotine
    Kenneth Perkins; Fiscal Year: 2005
    ..Secondary analyses may identify important individual characteristics associated with placebo responses, aiding in the prediction of which smokers ultimately are likely to benefit most from manipulation of placebo effects. ..
  54. Discrimination, Reinforcement, and Resistance to Change
    JOHN NEVIN; Fiscal Year: 2009
    ....
  55. The Cognitive Neuroscience of Human Category Learning
    F Ashby; Fiscal Year: 2009
    ..g., teaching radiologists to find tumors in x-rays). ..
  56. Tobacco Smoking, Nicotine and Negative Affect Relief
    Kenneth Perkins; Fiscal Year: 2009
    ..In sum, this research will help address the fundamental question of why cigarette smoking is reinforcing. ..
  57. NOVEL PHARMACOTHERAPY FOR TREATMENT OF COCAINE ADDICTION
    Frank Carroll; Fiscal Year: 2008
    ..abstract_text> ..
  58. PAVLOVIAN CONDITIONING PROCESSES INVOLVING NICOTINE
    RICK BEVINS; Fiscal Year: 2001
    ..intermittent delivery). Elucidating the behavioral processes underlying acquisition and expression of Pavlovian drug conditioning will have important implications for prevention and intervention strategies. ..
  59. NOVEL PHARMACOTHERAPIES FOR COCAINE DEPENDENCE
    Frank Carroll; Fiscal Year: 2001
    ..An ideal candidate compound would not only have efficacy in the preclinical models but would be safe, orally active, and potent, would not show tolerance or sensitization, and if abusable, would be less so than cocaine. ..
  60. FUNCTIONS AND MECHANISMS OF PERCEPTUAL LEARNING
    Barbara Dosher; Fiscal Year: 2003
    ....