avoidance learning

Summary

Summary: A response to a cue that is instrumental in avoiding a noxious experience.

Top Publications

  1. ncbi Inhibition of hippocampal Jun N-terminal kinase enhances short-term memory but blocks long-term memory formation and retrieval of an inhibitory avoidance task
    Lia R M Bevilaqua
    Centro de Memoria, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Ramiro Barcellos 2600 Anexo Porto Alegre, RS 90035 003, Brazil
    Eur J Neurosci 17:897-902. 2003
  2. ncbi Storage of spatial information by the maintenance mechanism of LTP
    Eva Pastalkova
    Departments of Physiology, Pharmacology, and Neurology, Robert F Furchgott Center for Neural and Behavioral Science, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Science 313:1141-4. 2006
  3. ncbi Amygdala inhibitory circuits and the control of fear memory
    Ingrid Ehrlich
    Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland
    Neuron 62:757-71. 2009
  4. pmc The habenula: from stress evasion to value-based decision-making
    Okihide Hikosaka
    National Eye Institute, National Institutes of Health, Bethesda, MD 20892 4435, USA
    Nat Rev Neurosci 11:503-13. 2010
  5. pmc The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses
    Thomas C Jhou
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Neuron 61:786-800. 2009
  6. pmc Is avoiding an aversive outcome rewarding? Neural substrates of avoidance learning in the human brain
    Hackjin Kim
    PLoS Biol 4:e233. 2006
  7. pmc Gamma neurons mediate dopaminergic input during aversive olfactory memory formation in Drosophila
    Hongtao Qin
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Curr Biol 22:608-14. 2012
  8. ncbi Functional neuroanatomy of aversion and its anticipation
    Jack B Nitschke
    The Waisman Laboratory for Brain Imaging and Behavior, Waisman Center, Department of Psychiatry, University of Wisconsin, 1500 Highland Avenue, Madison, WI 53705 2280, USA
    Neuroimage 29:106-16. 2006
  9. ncbi Opponent appetitive-aversive neural processes underlie predictive learning of pain relief
    Ben Seymour
    Wellcome Department of Imaging Neuroscience, 12 Queen Square, London WC1N 3BG, UK
    Nat Neurosci 8:1234-40. 2005
  10. pmc Detection and avoidance of a carnivore odor by prey
    David M Ferrero
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:11235-40. 2011

Detail Information

Publications348 found, 100 shown here

  1. ncbi Inhibition of hippocampal Jun N-terminal kinase enhances short-term memory but blocks long-term memory formation and retrieval of an inhibitory avoidance task
    Lia R M Bevilaqua
    Centro de Memoria, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Ramiro Barcellos 2600 Anexo Porto Alegre, RS 90035 003, Brazil
    Eur J Neurosci 17:897-902. 2003
    ..enhanced short-term memory (STM) but blocked long-term memory (LTM) formation and retrieval of an inhibitory avoidance learning task. No action of this drug on locomotor/exploratory activity or general anxiety state could be detected...
  2. ncbi Storage of spatial information by the maintenance mechanism of LTP
    Eva Pastalkova
    Departments of Physiology, Pharmacology, and Neurology, Robert F Furchgott Center for Neural and Behavioral Science, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Science 313:1141-4. 2006
    ..Thus, the mechanism maintaining LTP sustains spatial memory...
  3. ncbi Amygdala inhibitory circuits and the control of fear memory
    Ingrid Ehrlich
    Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland
    Neuron 62:757-71. 2009
    ..Here, we review current understanding and emerging concepts of how local inhibitory circuits in the amygdala control the acquisition, expression, and extinction of conditioned fear at different levels...
  4. pmc The habenula: from stress evasion to value-based decision-making
    Okihide Hikosaka
    National Eye Institute, National Institutes of Health, Bethesda, MD 20892 4435, USA
    Nat Rev Neurosci 11:503-13. 2010
    ..As a highly conserved structure in the brain, the habenula provides a fundamental mechanism for both survival and decision-making...
  5. pmc The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses
    Thomas C Jhou
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Neuron 61:786-800. 2009
    ..These findings suggest that aversive inputs from widespread brain regions and stimulus modalities converge onto the RMTg, which opposes reward and motor-activating functions of midbrain dopamine neurons...
  6. pmc Is avoiding an aversive outcome rewarding? Neural substrates of avoidance learning in the human brain
    Hackjin Kim
    PLoS Biol 4:e233. 2006
    b>Avoidance learning poses a challenge for reinforcement-based theories of instrumental conditioning, because once an aversive outcome is successfully avoided an individual may no longer experience extrinsic reinforcement for their behavior...
  7. pmc Gamma neurons mediate dopaminergic input during aversive olfactory memory formation in Drosophila
    Hongtao Qin
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Curr Biol 22:608-14. 2012
    ..We argue that DA-mediated CS-US association is formed in γ neurons followed by communication between γ and α/β neurons to drive consolidation...
  8. ncbi Functional neuroanatomy of aversion and its anticipation
    Jack B Nitschke
    The Waisman Laboratory for Brain Imaging and Behavior, Waisman Center, Department of Psychiatry, University of Wisconsin, 1500 Highland Avenue, Madison, WI 53705 2280, USA
    Neuroimage 29:106-16. 2006
    ..These results show that anticipation of aversion recruits key brain regions that respond to aversion, thereby potentially enhancing adaptive responses to aversive events...
  9. ncbi Opponent appetitive-aversive neural processes underlie predictive learning of pain relief
    Ben Seymour
    Wellcome Department of Imaging Neuroscience, 12 Queen Square, London WC1N 3BG, UK
    Nat Neurosci 8:1234-40. 2005
    ..This dual coding has parallels to 'opponent process' theories in psychology and promotes a formal account of prediction and expectation during pain...
  10. pmc Detection and avoidance of a carnivore odor by prey
    David M Ferrero
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:11235-40. 2011
    ..These data show how a single, volatile chemical detected in the environment can drive an elaborate danger-associated behavioral response in mammals...
  11. pmc Input to the lateral habenula from the basal ganglia is excitatory, aversive, and suppressed by serotonin
    Steven J Shabel
    Center for Neural Circuits and Behavior, Division of Biology, Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093, USA
    Neuron 74:475-81. 2012
    ..Our results also provide a link between antireward excitatory synapses and serotonin, a neuromodulator implicated in depression...
  12. ncbi Regulation of aversion to noxious food by Drosophila neuropeptide Y- and insulin-like systems
    Qi Wu
    Department of Cellular Biology and Biomedical and Health Sciences Institute, University of Georgia, 724 Biological Sciences Building, Athens, Georgia 30602, USA
    Nat Neurosci 8:1350-5. 2005
    ..Our results suggest that the coordinated activities of the conserved NPY- and insulin-like receptor signaling systems are essential for the dynamic regulation of noxious food intake according to the animal's energy state...
  13. ncbi Changes in brain activity related to eating chocolate: from pleasure to aversion
    D M Small
    Neuropsychology Cognitive Neuroscience Unit, and Northwestern Cognitive Brain Mapping Group, Northwestern University School of Medicine, Chicago, IL 60611, USA
    Brain 124:1720-33. 2001
    ..Therefore, these results support the hypothesis that there are two separate motivational systems: one orchestrating approach and another avoidance behaviours...
  14. pmc Heat avoidance is regulated by transient receptor potential (TRP) channels and a neuropeptide signaling pathway in Caenorhabditis elegans
    Dominique A Glauser
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA
    Genetics 188:91-103. 2011
    ..Our results show that TRPV channels and the FLP-21/NPR-1 neuropeptide signaling pathway determine the threshold for heat avoidance in C. elegans...
  15. pmc Mosquitoes smell and avoid the insect repellent DEET
    Zainulabeuddin Syed
    Honorary Maeda Duffey Laboratory, Department of Entomology, University of California Davis, 1 Shields Ave, Davis, CA 95616
    Proc Natl Acad Sci U S A 105:13598-603. 2008
    ..In a sugar-feeding assay, both female and male mosquitoes avoided DEET. In addition, mosquitoes responding only to physical stimuli avoided DEET...
  16. ncbi Neural circuits and mechanisms involved in Pavlovian fear conditioning: a critical review
    Jeansok J Kim
    Department of Psychology and Program in Neurobiology and Behavior, University of Washington, Guthrie Hall, Seattle, WA 98195 1525, USA
    Neurosci Biobehav Rev 30:188-202. 2006
    ..The purpose of this review is to critically evaluate the strengths and weaknesses of evidence indicating that fear conditioning depend crucially upon the amygdalar circuit and plasticity...
  17. ncbi Critical roles for anterior insula and dorsal striatum in punishment-based avoidance learning
    Stefano Palminteri
    Motivation, Brain and Behavior MBB Team, Institut du Cerveau et de la Moëlle épinière ICM, Hopital de la Pitie Salpetriere, 75013 Paris, France
    Neuron 76:998-1009. 2012
    ....
  18. ncbi Ascorbic acid supplementation could affect passive avoidance learning and memory in rat
    Siamak Shahidi
    Department of Physiology, Hamadan University of Medical Sciences, Hamedan, Iran
    Brain Res Bull 76:109-13. 2008
    ..of acute, short- and long-term pre-training administration of ascorbic acid (60,120 mg/kg) on passive avoidance learning (PAL) and memory in rats. Retention test was done 24h after training...
  19. ncbi Treadmill exercise enhances passive avoidance learning in rats: the role of down-regulated serotonin system in the limbic system
    Hsiun Ing Chen
    Department of Physiology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Neurobiol Learn Mem 89:489-96. 2008
    ..Our results demonstrated that treadmill exercise (1) improved the passive avoidance learning performance; (2) decreased the 5-HT level in the hippocampus; (3) decreased the expression of 5-HT(1A) ..
  20. pmc Synaptic potentiation onto habenula neurons in the learned helplessness model of depression
    Bo Li
    Center for Neural Circuits and Behavior, Department of Neuroscience, University of California at San Diego, La Jolla, California 92093, USA
    Nature 470:535-9. 2011
    ..Our results indicate that increased presynaptic action onto LHb neurons contributes to the rodent learned helplessness model of depression...
  21. ncbi Persistence of long-term memory storage requires a late protein synthesis- and BDNF- dependent phase in the hippocampus
    Pedro Bekinschtein
    Instituto de Biologia Celular y Neurociencias, UBA, Buenos Aires C1121ABG, Argentina
    Neuron 53:261-77. 2007
    ..We propose that memory formation and memory persistence share some of the same molecular mechanisms and that recurrent rounds of consolidation-like events take place in the hippocampus for maintenance of the memory trace...
  22. ncbi Neural correlates of response reversal: considering acquisition
    S Budhani
    Department of Psychology, University College London, London WC1E 6BT, UK
    Neuroimage 34:1754-65. 2007
    ..The implications of these data for recent accounts of response reversal and of response reversal impairments in specific neuropsychiatric populations are discussed...
  23. pmc Social modulation of learning in rats
    Ewelina Knapska
    Department of Psychology, University of Michigan, Ann Arbor, 48109, USA
    Learn Mem 17:35-42. 2010
    ..We argue that socially transferred fear is an adaptation that promotes defensive behavior to potentially dangerous situations in the environment...
  24. pmc The impact of facial emotional expressions on behavioral tendencies in women and men
    Eva Maria Seidel
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    J Exp Psychol Hum Percept Perform 36:500-7. 2010
    ..Moreover, our results highlight the importance of gender of poser effects when applying emotional expressions as stimuli...
  25. pmc Emotional memory impairments in a genetic rat model of depression: involvement of 5-HT/MEK/Arc signaling in restoration
    T M Eriksson
    Center of Molecular Medicine, Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
    Mol Psychiatry 17:173-84. 2012
    ....
  26. ncbi Blockade of 5-HT 1B receptors facilitates contextual aversive learning in mice by disinhibition of cholinergic and glutamatergic neurotransmission
    Therese M Eriksson
    Department of Neuroscience, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Neuropharmacology 54:1041-50. 2008
    ..Blockade of brain 5-HT(1B) heteroreceptors may represent a novel therapeutic strategy for restoration of deficient cholinergic and glutamatergic neurotransmission contributing to memory disorders...
  27. pmc Dopamine and octopamine influence avoidance learning of honey bees in a place preference assay
    Maitreyi Agarwal
    Department of Chemistry, University of Puerto Rico, San Juan, Puerto Rico
    PLoS ONE 6:e25371. 2011
    ..avoidance conditioning assay to probe effects of biogenic amines octopamine (OA) and dopamine (DA) on avoidance learning. In this new protocol non-harnessed bees associate a spatial color cue with mild electric shock punishment...
  28. pmc General learning ability regulates exploration through its influence on rate of habituation
    Kenneth R Light
    Rutgers University, Department of Psychology, Piscataway, NJ 08854, USA
    Behav Brain Res 223:297-309. 2011
    ..In total, these results indicate that the relationship between exploration and general learning abilities is accounted for by the impact of habituation (itself a form of learning) on behaviors indicative of exploration...
  29. ncbi Effect of donepezil and lercanidipine on memory impairment induced by intracerebroventricular streptozotocin in rats
    Swapnil Sonkusare
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, S A S Nagar 160062, Punjab, India
    Life Sci 77:1-14. 2005
    ..3 mg/kg) showed significant improvement in memory. When administered together, the effect of combination of these two drugs on memory and cholinesterase activity was higher than that obtained with either of the drugs when used alone...
  30. pmc Minocycline synergizes with N-acetylcysteine and improves cognition and memory following traumatic brain injury in rats
    Samah G Abdel Baki
    Departments of Physiology and Pharmacology, State University of New York Downstate Medical Center, Brooklyn, New York, United States of America
    PLoS ONE 5:e12490. 2010
    ..The drugs examined (minocycline (MINO), N-acetylcysteine (NAC), simvastatin, cyclosporine A, and progesterone) had FDA-approval for uses other than TBI and limited brain injury in experimental TBI models...
  31. pmc Ghrelin enhances olfactory sensitivity and exploratory sniffing in rodents and humans
    Jenny Tong
    Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Neurosci 31:5841-6. 2011
    ..This novel role is consistent with ghrelin's overall function as a signal amplifier at the molecular interface between environmental and nutritional cues and neuroendocrine circuits controlling energy homeostasis...
  32. ncbi Intraamygdaloid microinjection of acylated-ghrelin influences passive avoidance learning
    Krisztián Tóth
    Institute of Physiology, Pecs University Medical School, Pecs, Hungary
    Behav Brain Res 202:308-11. 2009
    ..Our results suggest that intraamygdaloid A-Ghr enhances learning processes and memory in aversive situations, and this effect can specifically be prevented by ANT pretreatment...
  33. ncbi Effects of ventral tegmental area stimulation on the acquisition and long-term retention of active avoidance learning
    Anton Ilango
    Leibniz Institute for Neurobiology, Brenneckestrasse 6, D 39118 Magdeburg, Germany
    Behav Brain Res 225:515-21. 2011
    The development of avoidance learning depends on dopamine release in forebrain regions. Previous studies indicated that rewarding brain stimulation facilitated two-way active avoidance learning...
  34. ncbi Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain
    M R Picciotto
    CNRS UA D1284 Neurobiologie Moleculaire, Institut Pasteur, Paris, France
    Nature 374:65-7. 1995
    ..Paradoxically, mutant mice are able to perform better than their non-mutant siblings on this task...
  35. ncbi Sensorimotor and cognitive deficits after transient middle cerebral artery occlusion in the mouse
    Valentine Bouet
    UMR 6185 CNRS, Neurodegenerescence models and therapeutic strategies, University of Caen Basse Normandie, Cyceron, Bd H Becquerel BP 5229, F 14074 Caen cedex, France
    Exp Neurol 203:555-67. 2007
    ....
  36. ncbi The effects of predator odors in mammalian prey species: a review of field and laboratory studies
    Raimund Apfelbach
    Tierphysiologie, Zoologisches Institut, Universitat Tubingen, Auf der Morgenstelle 28, D 72076 Tubingen, Germany
    Neurosci Biobehav Rev 29:1123-44. 2005
    ..Recent research is starting to uncover the neural circuitry activated by predator odors, leading to hypotheses about how such activation leads to observable effects on reproduction, foraging and feeding...
  37. ncbi (-)-Epigallocatechin-3-gallate prevents lipopolysaccharide-induced elevation of beta-amyloid generation and memory deficiency
    Young Kyoung Lee
    College of Pharmacy, Chungbuk National University 12, Heungduk gu, Cheongju, Chungbuk 361 763, Republic of Korea
    Brain Res 1250:164-74. 2009
    ....
  38. ncbi Approach and avoidance learning in patients with major depression and healthy controls: relation to anhedonia
    H W Chase
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, UK
    Psychol Med 40:433-40. 2010
    ....
  39. pmc Impaired Pavlovian fear extinction is a common phenotype across genetic lineages of the 129 inbred mouse strain
    M Camp
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse, NIH, Bethesda, MD, USA
    Genes Brain Behav 8:744-52. 2009
    ..Taken together, these data show that impaired fear extinction is a phenotypic feature common across 129 substrains, and provide preliminary evidence that impaired fear extinction in 129S1 may reflect a pro-fear incubation-like process...
  40. pmc Short- and long-term memory in Drosophila require cAMP signaling in distinct neuron types
    Allison L Blum
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Curr Biol 19:1341-50. 2009
    ..At the neuroanatomical level, however, different temporal stages of memory can engage distinct neural circuits, a notion that has not been conceptually integrated with the cellular view...
  41. ncbi Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories
    Niels Plath
    Molecular Neurobiology, Department of Biology Chemistry Pharmacy, Freie Universitat Berlin, 14195 Berlin, Germany
    Neuron 52:437-44. 2006
    ..In addition, long-term depression is significantly impaired. Together, these results demonstrate a critical role for Arc/Arg3.1 in the consolidation of enduring synaptic plasticity and memory storage...
  42. ncbi Intracerebroventricular insulin enhances memory in a passive-avoidance task
    C R Park
    Interdisciplinary Program in Neurobiology and Behavior, University of Washington, Seattle, WA 98125, USA
    Physiol Behav 68:509-14. 2000
    ..This difference is consistent with an enhanced memory for the negative consequences of entering...
  43. pmc Stimuli inevitably generated by behavior that avoids electric shock are inherently reinforcing
    J A Dinsmoor
    Department of Psychology, Indiana University, Bloomington 47405 7007, USA
    J Exp Anal Behav 75:311-33. 2001
    ....
  44. ncbi Changes in rat olfactory detection performance induced by orexin and leptin mimicking fasting and satiation
    A K Julliard
    Laboratoire de Neurosciences Sensorielles, Comportement, Cognition, CNRS, UMR 5020, Universite de Lyon, Lyon 1, 50 avenue Tony Garnier, 69366 Lyon Cedex 07, France
    Behav Brain Res 183:123-9. 2007
    ..Orexin and leptin modulate the olfactory performance in a similar way as do physiological induced fasting and satiation and appear to be important factors in the interdependency of olfaction and food intake...
  45. ncbi Amyloid precursor protein knockout mice show age-dependent deficits in passive avoidance learning
    Yann Senechal
    Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Lichtstrasse 35, CH 4056 Basel, Switzerland
    Behav Brain Res 186:126-32. 2008
    ..The results suggest that APP and/or its proteolytic derivatives may play a role in long-term memory in adult brain and/or may be required during the development and maintenance of neuronal networks involved in this type of memory...
  46. ncbi Differential neuromodulation of acquisition and retrieval of avoidance learning by the lateral habenula and ventral tegmental area
    Jason Shumake
    Leibniz Institute for Neurobiology, D 39118 Magdeburg, Germany
    J Neurosci 30:5876-83. 2010
    ..to the inhibition of dopaminergic neurons during loss of reward, as well as to deficits in escape and avoidance learning. We hypothesized that a dopamine signal might underlie the negative reinforcement of avoidance responses and ..
  47. ncbi The impact of selective amygdala, orbital frontal cortex, or hippocampal formation lesions on established social relationships in rhesus monkeys (Macaca mulatta)
    Christopher J Machado
    Department of Neurobiology and Anatomy, University of Texas Health Science Center, TX, USA
    Behav Neurosci 120:761-86. 2006
    ..Interpretation of results in relation to cognitive processes mediated by each structure is discussed...
  48. ncbi The automatic evaluation of novel stimuli
    Kimberly L Duckworth
    Department of Psychology, New York University, New York 10003, USA
    Psychol Sci 13:513-9. 2002
    ..A final experiment revealed that exposure to novel stimuli produces muscular predispositions to approach or avoid them...
  49. ncbi Glucocorticoid enhancement of memory consolidation in the rat is blocked by muscarinic receptor antagonism in the basolateral amygdala
    A E Power
    Center for the Neurobiology of Learning and Memory, and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
    Eur J Neurosci 12:3481-7. 2000
    ....
  50. ncbi Approach and avoidance in fear of spiders
    Mike Rinck
    Dresden University of Technology, Germany
    J Behav Ther Exp Psychiatry 38:105-20. 2007
    ..Moreover, compatibility effects predicted fear-related behavior independently of questionnaires. Potential applications, extensions, and limitations of the findings are discussed...
  51. ncbi Differential contributions of the basolateral and central nuclei of the amygdala in the negative affective component of chemical somatic and visceral pains in rats
    Sachi Tanimoto
    Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Eur J Neurosci 18:2343-50. 2003
    ..Taken together, these results suggest that activation of distinct amygdaloid nuclei could differentially contribute to chemical somatic and visceral noxious stimuli-induced negative affective, but not sensory components of pains...
  52. ncbi A systems approach to the cellular analysis of associative learning in the pond snail Lymnaea
    P R Benjamin
    Sussex Centre for Neuroscience, School of Biological Sciences, University of Sussex, Falmer, Brighton, East Sussex, BN1 9QG, UK
    Learn Mem 7:124-31. 2000
    ..Available information on the synaptic connectivity and transmitter content of identified neurons within the Lymnaea circuits will allow further work on the synaptic and molecular mechanisms of learning and memory...
  53. ncbi The effects of fear and anger facial expressions on approach- and avoidance-related behaviors
    Abigail A Marsh
    Department of Psychology, Harvard University, Cambridge, MA, USA
    Emotion 5:119-24. 2005
    ..Although the fear expression may signal that a threat is present in the environment, the effect of the expression on conspecifics may be in part to elicit approach...
  54. ncbi Differential involvement of the dorsal hippocampus in passive avoidance in C57bl/6J and DBA/2J mice
    Petra J J Baarendse
    Center for Neurogenomics and Cognitive Research and Institute for Neurosciences INW, Vrije Universiteit Amsterdam, The Netherlands
    Hippocampus 18:11-9. 2008
    ....
  55. ncbi Innate versus learned odour processing in the mouse olfactory bulb
    Ko Kobayakawa
    Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Tokyo 113 0032, Japan
    Nature 450:503-8. 2007
    ..These results indicate that, in mice, aversive information is received in the olfactory bulb by separate sets of glomeruli, those dedicated for innate and those for learned responses...
  56. pmc Aversive reinforcement improves visual discrimination learning in free-flying honeybees
    Aurore Avarguès-Weber
    Universite de Toulouse, UPS, Centre de Recherches sur la Cognition Animale, Toulouse, France
    PLoS ONE 5:e15370. 2010
    ..As we assumed that quinine acts as an aversive stimulus, we analyzed whether aversion, if any, is based on an aversive sensory input at the gustatory level or on a post-ingestional malaise following quinine feeding...
  57. pmc An internal thermal sensor controlling temperature preference in Drosophila
    Fumika N Hamada
    National Center for Behavioral Genomics, Volen Center for Complex Systems, Biology Department, Brandeis University MS 008, 415 South Street, Waltham, Massachusetts 02454, USA
    Nature 454:217-20. 2008
    ..This provides a potentially general strategy for robustly selecting a narrow temperature range optimal for survival...
  58. pmc Individual differences in insular sensitivity during loss anticipation predict avoidance learning
    Gregory R Samanez-Larkin
    Department of Psychology, Stanford University, Stanford, CA 94305 2130, USA
    Psychol Sci 19:320-3. 2008
    ..These findings suggest that in addition to correlating with self-reported anxiety, heightened insular sensitivity may promote learning to avoid loss...
  59. ncbi The mouse light/dark box test
    Michel Bourin
    Faculty of Medicine, EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculté de Médecine BP 53508, 44035 Nantes cedex 1, France
    Eur J Pharmacol 463:55-65. 2003
    ..g. serotonergic drugs or drugs acting on neuropeptide receptors) can be detected using this paradigm. It has the advantages of being quick and easy to use, without requiring the prior training of animals...
  60. ncbi The consolidation of new but not reactivated memory requires hippocampal C/EBPbeta
    S M Taubenfeld
    Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    Nat Neurosci 4:813-8. 2001
    ..C/EBPbeta is an evolutionarily conserved genetic marker that has a selective role in the consolidation of new but not reactivated memories in the hippocampus...
  61. ncbi Differentiable contributions of human amygdalar subregions in the computations underlying reward and avoidance learning
    Charlotte Prévost
    Trinity College Institute of Neuroscience and School of Psychology, Trinity College, Dublin, Ireland
    Eur J Neurosci 34:134-45. 2011
    ..subregions within the human amygdala during two different types of instrumental conditioning: reward and avoidance learning. Through the application of a computational-model-based analysis, we found evidence for a dissociation ..
  62. ncbi Actin polymerization-dependent increase in synaptic Arc/Arg3.1 expression in the amygdala is crucial for the expression of aversive memory associated with drug withdrawal
    Yao Liu
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China
    J Neurosci 32:12005-17. 2012
    ..1 is a crucial mediator for actin polymerization functions, and, thus, underscores the unknown details of how actin polymerization mediates synaptic plasticity and memory...
  63. ncbi Mushroom body efferent neurons responsible for aversive olfactory memory retrieval in Drosophila
    Julien Séjourné
    Genes and Dynamics of Memory Systems, Neurobiology Unit, CNRS, Ecole Superieure de Physique et de Chimie Industrielles, Paris, France
    Nat Neurosci 14:903-10. 2011
    ..As the lateral horn has been implicated in innate responses to repellent odorants, we propose that MB-V2 neurons recruit the olfactory pathway involved in innate odor avoidance during memory retrieval...
  64. ncbi Uncompetitive NMDA receptor antagonists attenuate NMDA-induced impairment of passive avoidance learning and LTP
    W Zajaczkowski
    Department of Pharmacology, Merz and Co, Frankfurt M, Germany
    Neuropharmacology 36:961-71. 1997
    ..Dark avoidance learning was impaired by systemic NMDA administration (starting at 25 mg/kg) that was not related to either toxic ..
  65. pmc Onset and progression of behavioral and molecular phenotypes in a novel congenic R6/2 line exhibiting intergenerational CAG repeat stability
    Randi Michelle Cowin
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 6:e28409. 2011
    ..Data from TR-FRET suggest an association of mutant protein state changes (soluble versus aggregated) in disease onset and progression...
  66. ncbi Effect of MK-801-induced impairment of inhibitory avoidance learning in zebrafish via inactivation of extracellular signal-regulated kinase (ERK) in telencephalon
    Ming Chong Ng
    Department of Life Science, National Taiwan Normal University, Taipei, Taiwan
    Fish Physiol Biochem 38:1099-106. 2012
    ..First, we established a new system to investigate the inhibitory avoidance learning of zebrafish where they were trained to refrain from swimming from a shallow compartment to a deep ..
  67. ncbi Human avoidance and approach learning: evidence for overlapping neural systems and experiential avoidance modulation of avoidance neurocircuitry
    Michael W Schlund
    Department of Behavior Analysis, University of North Texas, Denton TX, PO Box 310919, Denton, TX 76203, USA
    Behav Brain Res 225:437-48. 2011
    ....
  68. ncbi Involvement of insulin-like peptide in long-term synaptic plasticity and long-term memory of the pond snail Lymnaea stagnalis
    Jun Murakami
    Laboratory of Functional Biology, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki 769 2193, Japan
    J Neurosci 33:371-83. 2013
    ..These data suggest that MIPs trigger changes in synaptic connectivity that may be correlated with the consolidation of taste aversion learning into CTA-LTM in the Lymnaea CNS...
  69. ncbi Progressive cognitive impairment and anxiety induction in the absence of plaque deposition in C57BL/6 inbred mice expressing transgenic amyloid precursor protein
    Kang Woo Lee
    Department of Neuroscience, Ewha Institute of Neuroscience and Medical Research Institute, Ewha Womans University School of Medicine, Seoul, Korea
    J Neurosci Res 76:572-80. 2004
    ....
  70. ncbi The lateral habenula regulates defensive behaviors through changes in 5-HT-mediated neurotransmission in the dorsal periaqueductal gray matter
    Roger Luis Henschel Pobbe
    Department of Pharmacology, School of Medicine, University of Sao Paulo, Av Bandeirantes, 3900, CEP 14049 900 Ribeirao Preto, Brazil
    Neurosci Lett 479:87-91. 2010
    ..While stimulation of 5-HT(1A) receptors selectively affects escape performance, 5-HT(2A/2C) receptors modulate both inhibitory avoidance and escape...
  71. ncbi Immunohistochemical estimation of brain choline acetyltransferase and somatostatin related to the impairment of avoidance learning induced by thiamine deficiency
    O Nakagawasai
    Department of Pharmacology, Tohoku Pharmaceutical University, Sendai, Japan
    Brain Res Bull 52:189-96. 2000
    We have found that thiamine-deficient (TD) rats show significant impairment of avoidance learning on the 25th day after the start of TD diet, as measured by passive-avoidance task. Administration of physostigmine (0.1 mg/kg, i.p...
  72. ncbi Approach and avoidance learning in obsessive-compulsive disorder
    Tanja Endrass
    Humboldt Universitat zu Berlin, Institut fur Psychologie, Berlin, Germany
    Depress Anxiety 28:166-72. 2011
    ..The purpose of this study was to examine feedback-based learning and to investigate whether learning from positive and negative feedback is differentially altered in OCD...
  73. ncbi Regulation of nuclear factor kappaB in the hippocampus by group I metabotropic glutamate receptors
    Kenneth J O'Riordan
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 26:4870-9. 2006
    ....
  74. pmc Coordinated activity of ventral tegmental neurons adapts to appetitive and aversive learning
    Yunbok Kim
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, United States America
    PLoS ONE 7:e29766. 2012
    ..These patterns also adapted when task contingencies were changed. Taken together, these data demonstrate that VTA neurons organize flexibly as functional networks to support appetitive and aversive learning...
  75. ncbi Sociality, pathogen avoidance, and the neuropeptides oxytocin and arginine vasopressin
    Martin Kavaliers
    Department of Psychology, Social Science Centre, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Psychol Sci 22:1367-74. 2011
    ..The evidence reviewed here suggests that OT and AVP likely play parallel roles in modulating the recognition and avoidance of socially relevant pathogen threat in both humans and rodents...
  76. ncbi Susceptibility of a potential animal model for pathological anxiety to chronic mild stress
    Amber R Salomons
    Department of Animals in Science and Society, Division of Animal Welfare and Laboratory Animal Science, Utrecht University, Utrecht, The Netherlands
    Behav Brain Res 209:241-8. 2010
    ..These results support the hypothesis that 129P3/J mice might be an interesting model for pathological anxiety...
  77. ncbi Glutamatergic activation of anterior cingulate cortex mediates the affective component of visceral pain memory in rats
    Ni Yan
    Neuroscience Research Laboratory, Department of Biology and Chemistry, City University of Hong Kong, Hong Kong, China
    Neurobiol Learn Mem 97:156-64. 2012
    ..pACC activation is critical for the memory processing involved in long-term negative affective state and prediction of aversive stimuli by contextual cue...
  78. ncbi 2,3,5-Trimethyl-3-thiazoline (TMT), a component of fox odor - just repugnant or really fear-inducing?
    Markus Fendt
    Animal Physiology, University of Tubingen, Auf der Morgenstelle 28 D 72076 Tübingen, Germany
    Neurosci Biobehav Rev 32:1259-66. 2008
    ..Therefore, TMT is still a viable alternative stimulus to natural predator odors to investigate effects of predator odors on behavior...
  79. ncbi Retraining automatic action-tendencies to approach alcohol in hazardous drinkers
    Reinout W Wiers
    University of Amsterdam, Department of Psychology, Roetersstraat 15, 1018 WB Amsterdam, The Netherlands
    Addiction 105:279-87. 2010
    ..The main aim of this study was to test whether automatic action-tendencies to approach alcohol can be modified, and whether this affects drinking behaviour...
  80. ncbi Behavioral and electrophysiological studies of chronic oral administration of L-type calcium channel blocker verapamil on learning and memory in rats
    Reza Lashgari
    Neuroscience Research Center and Department of Physiology, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
    Behav Brain Res 171:324-8. 2006
    ..and orally at different doses (10, 20 and 50 mg/kg) was used to investigate learning and memory by passive avoidance learning. LTP in perforant-DG synapses was assessed (by either 200 or 400 Hz tetanization) in order to investigate ..
  81. ncbi A temporal difference account of avoidance learning
    Michael Moutoussis
    Tolworth Hospital, Surbiton, England
    Network 19:137-60. 2008
    ..The model accounts for normal conditioned avoidance learning, the persistence of responding in extinction, and critical effects of dopamine blockade, notably that ..
  82. ncbi Interhippocampal transfer in passive avoidance task modifies metabolic activity in limbic structures
    J M Cimadevilla
    Department of Neuroscience, University of Almeria, Carretera de Sacramento s n, Almeria, Spain
    Hippocampus 21:48-55. 2011
    ..By combining behavioral tasks and cytochrome oxidase histochemistry we demonstrated that several brain structures, including the hippocampus, amygdala and other related regions, change their activity under the above-mentioned treatments...
  83. ncbi Neuronal cell adhesion molecule deletion induces a cognitive and behavioral phenotype reflective of impulsivity
    L D Matzel
    Department of Psychology, Program in Behavioural Neuroscience, Rutgers University, Piscataway, NJ 08854, USA
    Genes Brain Behav 7:470-80. 2008
    ....
  84. ncbi Avoidance motivation and choking under pressure in soccer penalty shootouts
    Geir Jordet
    Department of coaching and psychology, Norwegian School of Sport Sciences, Oslo, Norway
    J Sport Exerc Psychol 30:450-7. 2008
    ..Thus, avoidance motivation may help explain why professional athletes occasionally choke under pressure...
  85. ncbi Predator odor-induced conditioned fear involves the basolateral and medial amygdala
    Lorey K Takahashi
    Department of Psychology, University of Hawaii at Manoa, Manoa, HI, USA
    Behav Neurosci 121:100-10. 2007
    ....
  86. ncbi Scopolamine-induced learning impairment reversed by physostigmine in zebrafish
    Yeon Hwa Kim
    Department of Biological Sciences, Institute of Molecular and Cellular Biology, Inha University, 253 Yong Hyun Dong, Nam Gu, Incheon 402 751, Republic of Korea
    Neurosci Res 67:156-61. 2010
    ..These results show that scopolamine impairs both the acquisition of passive avoidance response and retention of the learned response, and that physostigmine rescues the amnesic effects of scopolamine in zebrafish...
  87. ncbi The anxiolytic and analgesic properties of fenobam, a potent mGlu5 receptor antagonist, in relation to the impairment of learning
    Wolfgang Jacob
    In Vivo Pharmacology, Merz Pharmaceuticals GmbH, Frankfurt am Main, Germany
    Neuropharmacology 57:97-108. 2009
    ..Our results indicate that the beneficial effects of fenobam occur in a similar dose range as the potential side-effects...
  88. ncbi Corticohippocampal contributions to spatial and contextual learning
    Rebecca D Burwell
    Department of Psychology, Brown University, Providence, Rhode Island 02912, USA
    J Neurosci 24:3826-36. 2004
    ..The evidence that different brain systems underlie spatial navigation and contextual learning has implications for research on memory when parahippocampal regions are involved...
  89. ncbi Different temporal profiles of amnesia after intra-hippocampus and intra-amygdala infusions of anisomycin
    Clinton E Canal
    Neuroscience Program, University of Illinois, 603 East Daniel Street, Champaign, IL 61820, USA
    Behav Neurosci 121:732-41. 2007
    ..The distinct temporal properties for amnesia following anisomycin injections into the hippocampus or amygdala may reflect different consequences for memory of perturbations of the neural system in which the manipulation is made...
  90. ncbi Inhibition of protein kinase A activity during conditioned taste aversion retrieval: interference with extinction or reconsolidation of a memory?
    Ming Teng Koh
    Department of Psychology, University of Washington, Seattle, WA 98195 1525, USA
    Neuroreport 14:405-7. 2003
    ..Results confirm recent findings that stored memories become more labile when they are retrieved and extend these findings to CTA memories...
  91. ncbi Response of Drosophila to wasabi is mediated by painless, the fly homolog of mammalian TRPA1/ANKTM1
    Bader Al-Anzi
    Division of Biology 156 29, California Institute of Technology, Pasadena, California 91125, USA
    Curr Biol 16:1034-40. 2006
    ..Our results suggest that the stinging sensation of isothiocyanate is caused by activation of an evolutionarily conserved molecular pathway that is also used for nociception...
  92. ncbi Odour avoidance learning in the larva of Drosophila melanogaster
    Sukant Khurana
    Tata Institute of Fundamental Research, National Centre for Biological Sciences, Bangalore 560 065, India
    J Biosci 34:621-31. 2009
    ..The same method of analysis when applied to learning mutants dunce, amnesiac, rutabaga and radish reveals memory deficits characteristic of the mutant strains...
  93. ncbi Involvement of actin rearrangements within the amygdala and the dorsal hippocampus in aversive memories of drug withdrawal in acute morphine-dependent rats
    Yuan yuan Hou
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
    J Neurosci 29:12244-54. 2009
    ....
  94. pmc Uncertainty during anticipation modulates neural responses to aversion in human insula and amygdala
    I Sarinopoulos
    Department of Psychology, Michigan State University, East Lansing, MI 48824, USA
    Cereb Cortex 20:929-40. 2010
    ..Findings provide the first evidence of the brain mechanisms of covariation bias and highlight the temporal dynamics of ACC, insula, and amygdala recruitment for processing aversion in the context of uncertainty...
  95. pmc The L-Type voltage-gated calcium channel Cav1.3 mediates consolidation, but not extinction, of contextually conditioned fear in mice
    Brandon C McKinney
    Medical Scientist Training Program, University of Michigan, Ann Arbor, Michigan 48109, USA
    Learn Mem 13:584-9. 2006
    ..3 knockout mice is not likely the result of an inability to encode the context, but may reflect an inability to make the association between the context and the unconditioned stimulus...
  96. ncbi Effects of histamine and cholinergic systems on memory retention of passive avoidance learning in rats
    Maryam Eidi
    Department of Biology, Sciences and Research Campus, Azad University, Tehran, Iran
    Eur J Pharmacol 465:91-6. 2003
    ..It is concluded that histaminergic and cholinergic systems have opposing effects on memory retention. Also, the histaminergic system elicits an interaction with the cholinergic system in memory retention...
  97. ncbi Enhanced inhibitory avoidance learning prevents the long-term memory-impairing effects of cycloheximide, a protein synthesis inhibitor
    Arnulfo Díaz-Trujillo
    Departamento de Neurobiologia Conductual y Cognitiva, Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Campus Juriquilla, Queretaro 76230, Mexico
    Neurobiol Learn Mem 91:310-4. 2009
    ....
  98. ncbi The role of muscarinic and nicotinic cholinergic neurotransmission in aversive conditioning: comparing pavlovian fear conditioning and inhibitory avoidance
    Matthew R Tinsley
    Department of Psychology, University of California, Los Angeles, California 90095, USA
    Learn Mem 11:35-42. 2004
  99. pmc Retrieval does not induce reconsolidation of inhibitory avoidance memory
    Martin Cammarota
    Memory Research Laboratory, Institute for Cell Biology and Neuroscience Prof Dr Eduardo de Robertis, School of Medicine, University of Buenos Aires, Ciudad Autonoma de Buenos Aires, CP 1121, Argentina
    Learn Mem 11:572-8. 2004
    ..Hence, our results indicate that there is no retrieval-induced, protein synthesis-dependent process that would cause reconsolidation of IA memory...
  100. pmc Involvement of the rostral anterior cingulate cortex in consolidation of inhibitory avoidance memory: interaction with the basolateral amygdala
    Emily L Malin
    Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
    Neurobiol Learn Mem 87:295-302. 2007
    ....
  101. ncbi Mild hypoxia preconditioning prevents impairment of passive avoidance learning and suppression of brain NGFI-A expression induced by severe hypoxia
    Elena Rybnikova
    Laboratory of Neuroendocrinology, Pavlov Institute of Physiology Russian Academy of Sciences, 199034 St Petersburg, Russia
    Behav Brain Res 160:107-14. 2005
    ..The preconditioning up-regulated severe hypoxia-suppressed neocortical and hippocampal expression of NGFI-A, suggesting a possible role for NGFI-A in the neuroprotective mechanisms activated by hypoxic preconditioning...

Research Grants66

  1. Functions of Associative Auditory Cortical Plasticity
    Norman M Weinberger; Fiscal Year: 2013
    ..auditory memory should increase the level of memory strength, retention of acoustic details and facilitate avoidance learning. The findings have direct translational implications for the design and implementation of therapeutic ..
  2. The role of medial prefrontal cortex in active avoidance behavior
    Justin M Moscarello; Fiscal Year: 2013
    ..Signaled active avoidance learning can offer important insights into this transitional process...
  3. Acquisition and Expression of Avoidance: Computational Modeling and Human Studies
    Catherine E Myers; Fiscal Year: 2013
    ..There is a rich tradition of studying avoidance learning in animals, including work from our lab and others, but work directly linking animal data to human avoidance ..
  4. Emotional Reactivity and Capacity for Emotional Control in Psychopathic Individua
    Matthew Shane; Fiscal Year: 2011
    ..g. fear, anxiety) at levels sufficient to mediate behavioral control or motivate avoidance learning. While a consistent literature has indeed confirmed that psychopaths show reduced reactivity to aversive ..
  5. Neural mechanisms of avoidance learning and active coping via emotion regulation
    Mauricio R Delgado; Fiscal Year: 2013
    ..g., Salamone, 1994;LeDoux &Gorman, 2001). Yet, less is known about 1) human mechanisms of avoidance learning;2) alternative means of coping with negative affect that are dependent on higher-order cognition and control ..
  6. Neural mechanisms of extinction-resistant avoidance behavior
    Kevin D Beck; Fiscal Year: 2013
    ..basic science research program is developing an animal model for understanding the role of vulnerability in avoidance learning. Inbred Wistar-Kyoto rats are stress sensitive and acquire active avoidance response faster and to a higher ..
  7. Learning to avoid pain: Computational mechanisms and application to methamphetami
    TOR DESSART WAGER; Fiscal Year: 2013
    ..combination of two successful research traditions is a powerful approach that can provide new measures of avoidance learning in healthy individuals and drug abusers and links with animal models of addiction...
  8. Neural Correlates of Avoidance Learning in Substance Abuse
    Jody L Tanabe; Fiscal Year: 2013
    ..Aim 2. Determine the neural pathways involved in negative and positive reinforcement learning Aim 3. Determine if frontal-limbic activity differs in SDI compared to controls during negative and positive reinforcement learning ..
  9. CONDITIONAL DISCRIMINATION LEARNING
    Thomas Zentall; Fiscal Year: 1980
    ..conditional discrimination learning may involve not only A-B, and C-D approach learning but also, A-D, C-B avoidance learning and (2) similarity (identity) between the sample stimuli (A and C) and the comparison stimuli (B and D) can ..
  10. Apparatus for Testing Pain Sensitivity in Rodents
    Charles Gibbs; Fiscal Year: 2003
    ..The ability to change floor temperature rapidly allows for repeated trials with minimal avoidance learning. Each chamber will be able to produce an aversive, non-painful condition, using bright light...
  11. SOD/Catalase mimics for age-related learning impairment
    Michel Baudry; Fiscal Year: 2001
    ..They will be tested for acquisition and retention of 2 different tasks, an avoidance learning paradigm, and a fear-conditioning paradigm...
  12. HIPPOCAMPAL FUNCTION AFTER PRENATAL ETHANOL EXPOSURE
    H Swartzwelder; Fiscal Year: 1990
    ..This latter process will be correlated with passive avoidance learning. Our goals are 1) to demonstrate and describe the functional impact of prenatal ethanol exposure on the ..
  13. NICOTINE ADDICTION IN MICE LACKING THE NEURONAL NACHR
    MARINA PICCIOTTO; Fiscal Year: 2009
    ..We have identified hypersensitive passive avoidance learning as a long-lasting behavioral outcome of altering nicotinic acetylcholine receptor (nAChR) function during ..
  14. REWARD SHIFTS ENHANCE TOXIN AVOIDANCE AND NEOPHOBIA
    BRUCE LOMBARDI; Fiscal Year: 1980
    ..of the present research will be twofold, first to explore the mechanism by which reward shifts facilitate poison avoidance learning, and second to examine the effects of neophobia produced by shifts in reward on investigatory behavior.
  15. MOLECULAR MECHANISMS OF CONDITIONED TASTE AVERSION
    THOMAS HOUPT; Fiscal Year: 2004
    ..These experiments will contribute to an understanding of the neural pathways and molecular mechanisms underlying changes in food preferences that occur in eating disorders such as obesity and anorexia nervosa. ..
  16. Behavioral and Neural Effects of High Magnetic Fields
    THOMAS HOUPT; Fiscal Year: 2009
    ..Secondly, vestibular dysfunction is a common complaint and cause of injury (e.g. falling in the elderly), and this proposal contains novel approaches to investigating the inner ear and vestibular system ..
  17. Mechanisms Underlying the Cognitive Function of Sleep
    Subimal Datta; Fiscal Year: 2009
    ....
  18. Antipsychotic Drugs and Maternal Behavior: A Preclinical Investigation
    Ming Li; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  19. Emotional Mechanisms /Blood-Injection-Injury Phobia
    Olubunmi Olatunji; Fiscal Year: 2004
    ..This research will provide an important contribution to the understanding of the emotions that mediate BII phobia, thus potentially providing a foundation for incorporating effective treatment strategies. ..
  20. The Role of the Amygdala in Anesthetic-Induced Amnesia
    MICHAEL ALKIRE; Fiscal Year: 2006
    ..Understanding anesthesia requires understanding both phenomenon. We recently demonstrated, using inhibitory avoidance learning in rats, that the basolateral amygdala (BL) is critically nvolved with mediating the amnesic effects of ..
  21. Neuroanatomy of Anticipation in Anxiety Disorders
    Jack Nitschke; Fiscal Year: 2009
    ..g., anticipation that results in adaptive response) as well as understanding how dysfunction in this system occurs. ..
  22. Rapid DA-Acb signaling in ingestive behaviors
    MITCHELL ROITMAN; Fiscal Year: 2008
    ..These studies will establish the range of natural stimuli that promote rapid DA-Acb signaling - setting the foundation for examining aberrant signaling underlying drug addiction. [unreadable] [unreadable] [unreadable] [unreadable]..
  23. Temperament and Developmental Psychopathology
    David Rettew; Fiscal Year: 2008
    ..abstract_text> ..
  24. Mechanisms of Neural Mobilization for Chronic Pain
    STEVEN GEORGE; Fiscal Year: 2007
    ..These data may also provide support for a future clinical trial investigating the efficacy of median nerve NMT for patients with CTS. [unreadable] [unreadable] [unreadable]..
  25. Behavioral Interventions for Low Back Pain
    STEVEN GEORGE; Fiscal Year: 2007
    ....
  26. Predictors of Drug Related Attentional Biases among Crack/Cocaine Users with PTSD
    MATTHEW TULL; Fiscal Year: 2007
    ..Consequently, this study will have tremendous public health benefits. [unreadable] [unreadable] [unreadable]..
  27. IMPROVING CARE OF PANIC DISORDER IN PRIMARY CARE
    Michelle Craske; Fiscal Year: 2002
    ..abstract_text> ..
  28. Functional Neuroimaging in Anxiety and Fear
    Jack Nitschke; Fiscal Year: 2006
    ..abstract_text> ..
  29. Taste Coding by Neural Circuitry in the Brain Stem
    PATRICIA DI LORENZO; Fiscal Year: 2005
    ..By describing the taste responsivity of inputs and outputs of NTS cells, data from this project will help provide an understanding of information processing in the NTS. ..
  30. General Cognitive /Learning Deficits in Aged Mice
    LOUIS MATZEL; Fiscal Year: 2003
    ..These studies are a critical prelude to future work directed at the elucidation of the brain substrates for age-related declines in general cognitive/learning abilities. ..
  31. Markers of Risk for Anxiety Disorders
    Michelle Craske; Fiscal Year: 2003
    ..Measurement of eye gaze in youths to gauge ongoing conditioning and attentional processes represents a new methodology. ..
  32. Ribonucleotide monophosphates and umami taste
    Eugene Delay; Fiscal Year: 2003
    ..If IMP and GMP have identical taste qualities, and these qualities are the same as MSG and the other "umami" substance. ..
  33. L-amino and acid taste in mice.
    Eugene Delay; Fiscal Year: 2005
    ..g., diabetics, cardiovascular disease, aged). ..
  34. Ethanol & Anxiety: Cellular Mechanisms
    BRIAN MCCOOL; Fiscal Year: 2008
    ..These studies could therefore provide insight into the cellular mechanisms governing anxietyassociated relapse in human alcoholics. ..
  35. PREVENTING CHRONIC WHIPLASH PAIN: BIOBEHAVIORAL APPROACH
    DENNIS TURK; Fiscal Year: 2005
    ..The data from this trial will provide important information about the potential of early interventions to prevent chronic problems that afflict millions of MVA victims. ..
  36. THC Affects the Development of Executive Function
    Diana Dow Edwards; Fiscal Year: 2008
    ..abstract_text> ..
  37. NEURAL MEDIATION OF CONDITIONED TASTE AVERSIONS
    ILENE BERNSTEIN; Fiscal Year: 2004
    ....
  38. FAMILY CONFLICT AND DECISION MAKING FOR ADVANCED CANCER
    Laura Siminoff; Fiscal Year: 2004
    ..Cut-off scores will be provided for classifying concordant and discordant families. In addition, rich and detailed descriptive information about the family treatment decision-making process will be provided. ..
  39. Involvement of mGluR5 in inhibitory avoidance and aging
    Agnes Simonyi; Fiscal Year: 2004
    ..The proposed research seeks to identify the mGluR subtype required for memory formation in passive avoidance learning. Selective mGluR antagonists will be infused into the hippocampus after training the rats in a one-trial ..
  40. Effort-related Functions of Nucleus Accumbens Adenosine A2A Receptors
    John D Salamone; Fiscal Year: 2010
    ....
  41. Behavioral Pharmacology of Serotonin Inverse Agoinsts
    Ellen Walker; Fiscal Year: 2006
    ..Taken together, these experiments will provide a novel pharmacological and/or behavioral profile for 5-HT2C inverse agonists and neutral antagonists while testing hypotheses generated from in vitro data. ..
  42. Neuroscience at the Boundaries of Neurology and Psychiatry
    Neal Swerdlow; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  43. QUALITY OF LIFE IN ADULT CANCER SURVIVORS
    Charles Carver; Fiscal Year: 2002
    ..These people can continue providing important information about the experience of cancer survivorship and what qualities make the process easier or harder. ..
  44. LEAD: ATTENTION, IMPULSIVITY, AND DOPAMINE
    STEPHEN KIEFER; Fiscal Year: 2002
    ..abstract_text> ..
  45. PUBLIC ATTITUDES TOWARDS DEATH AND ORGAN PROCUREMENT
    Laura Siminoff; Fiscal Year: 2001
    ..Finally, a community dialogue will be implemented to interpret and disseminate the findings and provide recommendations to policy makers. ..
  46. PERIPHERAL GUSTATORY PROCESSING
    MARION ELIZABETH FRANK; Fiscal Year: 2010
    ..Also, elimination of taste disorders would improve the quality of life that depends on enjoyment of food and drink, a universal human need contributing much to human sociality. ..
  47. MOLECULAR ANALYSIS OF OLFACTORY SIGNALING
    Cornelia Bargmann; Fiscal Year: 2008
    ..Characterizing these signaling pathways may elucidate related pathways that are important in disease and injury states. ..
  48. Linking Affect to Action: Critical Contributions of the Orbitofrontal Cortex
    Geoffrey Schoenbaum; Fiscal Year: 2006
    ..The participation of minorities and women has been emphasized at each level (organizers, speakers, students). Thus the conference will address important scientific, social, and educational issues. [unreadable] [unreadable] [unreadable]..
  49. Society for the Stimulus Properties of Drugs Satellite
    Ellen Walker; Fiscal Year: 2005
    ..The SSPD Satellite to the EBPS 2005 Conference promises to coordinate, exchange, and disseminate information to further our understanding of drug abuse. ..
  50. Associatively-activated event representations
    Peter Holland; Fiscal Year: 2006
    ..The proposed research provides a basis for the understanding of basic processing of imaginal events in associative learning. ..
  51. Anxiety and Psychological Vulnerability in Chest Pain
    KAMILA WHITE; Fiscal Year: 2005
    ..Data from this research program will allow Dr. White to establish an empirical foundation from which to apply these data to the development of novel interventions for patients with NCCP. ..
  52. Cellular bases of noncoincidence learning in Hermissenda
    Joseph Farley; Fiscal Year: 2007
    ..Ratiometric fura-2 imaging methods will be used to see if the interstimulus intervals that result in successful EU-conditioning match a specific [Ca2+]i level. ..
  53. Bupropion and Secondary Motivational Effects of Nicotine
    ANTHONY RAUHUT; Fiscal Year: 2005
    ..S. population to 12% and 16%, accordingly. ..
  54. Novel Operant Thermal Assessments of Orofacial Pain
    JOHN NEUBERT; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  55. Cellular and Molecular Mechanisms of Learning in the Zebrafish
    David Glanzman; Fiscal Year: 2007
    ..Such an understanding will facilitate the development of treatments for Alzheimer's disease and other disorders of memory. [unreadable] [unreadable] [unreadable]..
  56. Cognitive Processing in Human Infants and Primates
    Justin Wood; Fiscal Year: 2007
    ....
  57. LEARNING AND REPRODUCTIVE BEHAVIOR
    Michael Domjan; Fiscal Year: 2005
    ..The research will further our understanding of Pavlovian learning and will integrate the functional approach of ethologists with the emphasis on learning mechanisms in traditional studies of associative learning. ..
  58. Striatal Acetylcholine and Behavioral Flexibility
    MICHAEL RAGOZZINO; Fiscal Year: 2005
    ....
  59. Cue dependency with intravenous nutrients and nicotine
    Neil Rowland; Fiscal Year: 2007
    ..These studies may help to develop ways in conditioned preferences can be manipulated to prevent or treat certain addictive disorders, including overeating. [unreadable] [unreadable] [unreadable]..
  60. Neural Substrates of Goal-Directed Learning in the Human Brain
    JOHN O DOHERTY; Fiscal Year: 2007
    ..This research could ultimately be relevant in developing treatments for such conditions in which habitized or compulsive behaviors are returned to goal-directed control. [unreadable] [unreadable] [unreadable]..
  61. Attentional Regulation of Plasticity in Auditory Cortex
    Daniel Polley; Fiscal Year: 2004
    ..abstract_text> ..
  62. Time's Eye: Aging and Attention to Emotional Stimuli
    Derek Isaacowitz; Fiscal Year: 2003
    ..The results would also have implications for the etiology and treatment of depression. ..
  63. Health Status, Age, and Emotion Regulation
    Susan Charles; Fiscal Year: 2009
    ....
  64. Structure and Assessment of Symptoms of Depression
    David Watson; Fiscal Year: 2007
    ..g., adolescents, pregnant and postpartum women, and older adults) and to modify the instrument as necessary for use with these populations. ..
  65. Substituted Amphetamines: NO-Dependent Mechanisms
    Yossef Itzhak; Fiscal Year: 2005
    ....