comprehension

Summary

Summary: The act or fact of grasping the meaning, nature, or importance of; understanding. (American Heritage Dictionary, 4th ed) Includes understanding by a patient or research subject of information disclosed orally or in writing.

Top Publications

  1. ncbi Parietal lobe: from action organization to intention understanding
    Leonardo Fogassi
    Dipartimento di Psicologia, Universita di Parma, Borgo Carissimi 10, 43100 Parma, Italy
    Science 308:662-7. 2005
  2. ncbi Action-based language: a theory of language acquisition, comprehension, and production
    Arthur M Glenberg
    Department of Psychology, Arizona State University, Tempe, AZ 85287, USA
    Cortex 48:905-22. 2012
  3. ncbi Cortical activation and synchronization during sentence comprehension in high-functioning autism: evidence of underconnectivity
    Marcel Adam Just
    Carnegie Mellon University, Center for Cognitive Brain Imaging, Department of Psychology, Pittsburgh, PA 15213, USA
    Brain 127:1811-21. 2004
  4. ncbi The neural bases of social cognition and story comprehension
    Raymond A Mar
    Department of Psychology, York University, Toronto M3J 1P3 Canada
    Annu Rev Psychol 62:103-34. 2011
  5. ncbi Understanding of informed consent in a low-income setting: three case studies from the Kenyan Coast
    C S Molyneux
    Kenya Medical Research Institute, PO Box 230, Kilifi, Kenya
    Soc Sci Med 59:2547-59. 2004
  6. ncbi Interventions to improve research participants' understanding in informed consent for research: a systematic review
    James Flory
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    JAMA 292:1593-601. 2004
  7. ncbi Seeing, acting, understanding: motor resonance in language comprehension
    Rolf A Zwaan
    Department of Psychology, Florida State University, Tallahassee, FL 32306 1270, USA
    J Exp Psychol Gen 135:1-11. 2006
  8. pmc The Genetics Concept Assessment: a new concept inventory for gauging student understanding of genetics
    Michelle K Smith
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
    CBE Life Sci Educ 7:422-30. 2008
  9. pmc Grasping ideas with the motor system: semantic somatotopy in idiom comprehension
    Véronique Boulenger
    Medical Research Council, Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 7EF, UK
    Cereb Cortex 19:1905-14. 2009
  10. ncbi Integration of word meaning and world knowledge in language comprehension
    Peter Hagoort
    F C Donders Centre for Cognitive Neuroimaging, University of Nijmegen, Nijmegen, Netherlands
    Science 304:438-41. 2004

Detail Information

Publications368 found, 100 shown here

  1. ncbi Parietal lobe: from action organization to intention understanding
    Leonardo Fogassi
    Dipartimento di Psicologia, Universita di Parma, Borgo Carissimi 10, 43100 Parma, Italy
    Science 308:662-7. 2005
    ..Thus, these neurons not only code the observed motor act but also allow the observer to understand the agent's intentions...
  2. ncbi Action-based language: a theory of language acquisition, comprehension, and production
    Arthur M Glenberg
    Department of Psychology, Arizona State University, Tempe, AZ 85287, USA
    Cortex 48:905-22. 2012
    ..a mechanism of motor control, paired controller/predictor models, has been exploited for language learning, comprehension, and production...
  3. ncbi Cortical activation and synchronization during sentence comprehension in high-functioning autism: evidence of underconnectivity
    Marcel Adam Just
    Carnegie Mellon University, Center for Cognitive Brain Imaging, Department of Psychology, Pittsburgh, PA 15213, USA
    Brain 127:1811-21. 2004
    ..of a group of high-functioning autistic participants was measured using functional MRI during sentence comprehension and the results compared with those of a Verbal IQ-matched control group...
  4. ncbi The neural bases of social cognition and story comprehension
    Raymond A Mar
    Department of Psychology, York University, Toronto M3J 1P3 Canada
    Annu Rev Psychol 62:103-34. 2011
    ..A third ALE meta-analysis was conducted with respect to story comprehension in order to examine the relation between ToM and stories...
  5. ncbi Understanding of informed consent in a low-income setting: three case studies from the Kenyan Coast
    C S Molyneux
    Kenya Medical Research Institute, PO Box 230, Kilifi, Kenya
    Soc Sci Med 59:2547-59. 2004
    ..These themes and emerging recommendations are expected to be relevant to, and would benefit from, experiences and insights of researchers working elsewhere...
  6. ncbi Interventions to improve research participants' understanding in informed consent for research: a systematic review
    James Flory
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    JAMA 292:1593-601. 2004
    ..Available data suggest that prospective research participants may frequently not understand information disclosed to them in the informed consent process. Little is known about how understanding can be improved...
  7. ncbi Seeing, acting, understanding: motor resonance in language comprehension
    Rolf A Zwaan
    Department of Psychology, Florida State University, Tallahassee, FL 32306 1270, USA
    J Exp Psychol Gen 135:1-11. 2006
    ..1st question asks whether visual motion that is associated with an action produces motor resonance in sentence comprehension. The 2nd question asks whether motor resonance is modulated during sentence comprehension...
  8. pmc The Genetics Concept Assessment: a new concept inventory for gauging student understanding of genetics
    Michelle K Smith
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
    CBE Life Sci Educ 7:422-30. 2008
    ....
  9. pmc Grasping ideas with the motor system: semantic somatotopy in idiom comprehension
    Véronique Boulenger
    Medical Research Council, Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 7EF, UK
    Cereb Cortex 19:1905-14. 2009
    ..These results indicate that semantic representations grounded in the sensory-motor system play a role in the composition of sentence-level meaning, even in the case of idioms...
  10. ncbi Integration of word meaning and world knowledge in language comprehension
    Peter Hagoort
    F C Donders Centre for Cognitive Neuroimaging, University of Nijmegen, Nijmegen, Netherlands
    Science 304:438-41. 2004
    ..Finally, oscillatory brain responses indicate that the brain keeps a record of what makes a sentence hard to interpret...
  11. ncbi The cortical language circuit: from auditory perception to sentence comprehension
    Angela D Friederici
    Max Planck Institute for Human Cognitive and Brain Sciences, Department of Neuropsychology, 04103 Leipzig, Germany
    Trends Cogn Sci 16:262-8. 2012
    Over the years, a large body of work on the brain basis of language comprehension has accumulated, paving the way for the formulation of a comprehensive model...
  12. pmc Discrimination of speech stimuli based on neuronal response phase patterns depends on acoustics but not comprehension
    Mary F Howard
    Department of Linguistics, University of Maryland, College Park, MD 20742, USA
    J Neurophysiol 104:2500-11. 2010
    ..in discrimination performance, suggesting a relationship between theta-band phase patterns and speech comprehension. This study investigates the nature of this relationship, hypothesizing that theta-band phase patterns ..
  13. ncbi Language comprehension in the bilingual brain: fMRI and ERP support for psycholinguistic models
    Walter J B van Heuven
    School of Psychology, University of Nottingham, Nottingham, UK
    Brain Res Rev 64:104-22. 2010
    In this paper, we review issues in bilingual language comprehension in the light of functional magnetic resonance imaging (fMRI) and event-related brain potential (ERP) data...
  14. ncbi Getting real about semantic illusions: rethinking the functional role of the P600 in language comprehension
    Harm Brouwer
    Center for Language and Cognition BCN Neuro Imaging Center, University of Groningen, The Netherlands
    Brain Res 1446:127-43. 2012
    In traditional theories of language comprehension, syntactic and semantic processing are inextricably linked. This assumption has been challenged by the 'semantic illusion effect' found in studies using event related brain potentials...
  15. ncbi Integration of iconic gestures and speech in left superior temporal areas boosts speech comprehension under adverse listening conditions
    Henning Holle
    University of Sussex, Department of Psychology, Falmer, Brighton, UK
    Neuroimage 49:875-84. 2010
    ..This experiment targets the brain bases of how iconic gestures and speech are integrated during comprehension. Areas of integration were identified on the basis of two classic properties of multimodal integration, ..
  16. ncbi Combining functional and anatomical connectivity reveals brain networks for auditory language comprehension
    Dorothee Saur
    Department of Neurology, Medical Physics, University Medical Center Freiburg, D 79106 Freiburg, Germany
    Neuroimage 49:3187-97. 2010
    ..approach is applied to the language domain to investigate the network topology of two levels of auditory comprehension: lower-level speech perception (i.e., phonological processing) and higher-level speech recognition (i.e...
  17. ncbi The role of pictures in improving health communication: a review of research on attention, comprehension, recall, and adherence
    Peter S Houts
    Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Patient Educ Couns 61:173-90. 2006
    ..To assess the effects of pictures on health communications...
  18. ncbi Prediction during language comprehension: benefits, costs, and ERP components
    Cyma Van Petten
    Department of Psychology, Binghamton University, State University of New York, Binghamton, NY 13902, USA
    Int J Psychophysiol 83:176-90. 2012
    ..has attracted research attention, but prediction has fallen in and out of favor as a likely factor in normal comprehension. We note that the common sense of this word includes both benefits for confirmed predictions and costs for ..
  19. pmc Impairment of actions chains in autism and its possible role in intention understanding
    Luigi Cattaneo
    Dipartimento di Neuroscienze, Universita di Parma, Via Volturno 39, 43100 Parma, Italy
    Proc Natl Acad Sci U S A 104:17825-30. 2007
    ..We propose that, as a consequence of this functional impairment, high-functioning autistic children may understand the intentions of others cognitively but lack the mechanism for understanding them experientially...
  20. ncbi Cognitive control and parsing: reexamining the role of Broca's area in sentence comprehension
    Jared M Novick
    University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Cogn Affect Behav Neurosci 5:263-81. 2005
    ..for the detection and resolution of incompatible stimulus representations; (2) the role of LIFG in sentence comprehension is to implement reanalysis in the face of misinterpretation; and (3) individual differences in cognitive ..
  21. pmc How numeracy influences risk comprehension and medical decision making
    Valerie F Reyna
    Department of Human Development, Cornell University, B44 Martha Van Rensselaer Hall, Ithaca, NY 14853, USA
    Psychol Bull 135:943-73. 2009
    ..To address this gap, we outline four theoretical approaches (psychophysical, computational, standard dual-process, and fuzzy trace theory), review their implications for numeracy, and point to avenues for future research...
  22. ncbi Neural mechanisms of language comprehension: challenges to syntax
    Gina R Kuperberg
    Department of Psychology, Tufts University, Medford, MA 02155, USA
    Brain Res 1146:23-49. 2007
    ..I suggest that normal language comprehension proceeds along at least two competing neural processing streams: a semantic memory-based mechanism, and a ..
  23. ncbi The role of left inferior frontal and superior temporal cortex in sentence comprehension: localizing syntactic and semantic processes
    Angela D Friederici
    Max Planck Institute of Cognitive Neuroscience, Leipzig, Germany
    Cereb Cortex 13:170-7. 2003
    ..These data indicate that both semantic and syntactic processes are supported by a temporo-frontal network with distinct areas specialized for semantic and syntactic processes...
  24. ncbi An alternative perspective on "semantic P600" effects in language comprehension
    Ina Bornkessel-Schlesewsky
    Independent Junior Research Group Neurotypology, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstrasse 1a, 04013 Leipzig, Germany
    Brain Res Rev 59:55-73. 2008
    The literature on the electrophysiology of language comprehension has recently seen a very prominent discussion of "semantic P600" effects, which have been observed, for example, in sentences involving an implausible thematic role ..
  25. ncbi Literacy and misunderstanding prescription drug labels
    Terry C Davis
    Department of Medicine Pediatrics, Louisiana State University Health Science Center, Shreveport, Louisiana 71104, USA
    Ann Intern Med 145:887-94. 2006
    ..Health literacy has increasingly been viewed as a patient safety issue and may contribute to medication errors...
  26. ncbi Contributions of emotional prosody comprehension deficits to the formation of auditory verbal hallucinations in schizophrenia
    Lucy Alba-Ferrara
    Roskamp Laboratory of Brain Development, Modulation and Repair Department of Psychiatry and Neurosciences, Morsani College of Medicine, University of South Florida, FL, USA
    Clin Psychol Rev 32:244-50. 2012
    ..Associations of positive symptoms with poor emotional prosody comprehension (EPC) have been reported at the phenomenological, behavioral, and neural levels...
  27. pmc Osmosis and diffusion conceptual assessment
    Kathleen M Fisher
    Department of Biology, San Diego State University, CA 92182 4614, USA
    CBE Life Sci Educ 10:418-29. 2011
    Biology student mastery regarding the mechanisms of diffusion and osmosis is difficult to achieve. To monitor comprehension of these processes among students at a large public university, we developed and validated an 18-item Osmosis and ..
  28. ncbi Isn't it ironic? An electrophysiological exploration of figurative language processing
    Stefanie Regel
    Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
    J Cogn Neurosci 23:277-93. 2011
    Although the neurocognitive processes underlying the comprehension of figurative language, especially metaphors and idioms, have been studied extensively, less is known about the processing of irony...
  29. ncbi Perception of patterns of musical beat distribution in phonological developmental dyslexia: significant longitudinal relations with word reading and reading comprehension
    Usha Goswami
    Centre for Neuroscience in Education, University of Cambridge, Cambridge, UK
    Cortex 49:1363-76. 2013
    ..2011). Performance in the musical task was most strongly associated with the auditory processing of rise time, even though beat structure was varied by manipulating the duration of the musical notes...
  30. pmc Comprehension of concrete and abstract words in semantic dementia
    Elizabeth Jefferies
    Department of Psychology University of York, UK
    Neuropsychology 23:492-9. 2009
    The vast majority of brain-injured patients with semantic impairment have better comprehension of concrete than abstract words...
  31. ncbi Cathodal transcranial direct current stimulation of the right Wernicke's area improves comprehension in subacute stroke patients
    Dae Sang You
    Department of Rehabilitation Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
    Brain Lang 119:1-5. 2011
    ..Here, we investigated the effect of tDCS on the comprehension of aphasic patients with subacute stroke...
  32. pmc Novel approach to parental permission and child assent for research: improving comprehension
    Theresa A O'Lonergan
    Department of Pediatrics, University of Colorado Denver, 13123 E 16th Ave, B218, Aurora, CO 80045, USA
    Pediatrics 127:917-24. 2011
    ..The overall hypothesis was that children and their parents exposed to a multimedia P/A process would have better comprehension compared with those exposed to a text-based process.
  33. ncbi Probabilistic word pre-activation during language comprehension inferred from electrical brain activity
    Katherine A DeLong
    Department of Cognitive Science, University of California San Diego, La Jolla, California 92093, USA
    Nat Neurosci 8:1117-21. 2005
    ..These findings are evidence that readers use the words in a sentence (as cues to their world knowledge) to estimate relative likelihoods for upcoming words...
  34. ncbi Imitation improves language comprehension
    Patti Adank
    University of Manchester, School of Psychological Sciences, M139PL Manchester, United Kingdom
    Psychol Sci 21:1903-9. 2010
    ..However, the effect of imitation on action comprehension is unclear...
  35. ncbi Simple composition: a magnetoencephalography investigation into the comprehension of minimal linguistic phrases
    Douglas K Bemis
    Department of Psychology, New York University, New York, New York 10003, USA
    J Neurosci 31:2801-14. 2011
    ....
  36. ncbi Involvement of cognitive control in sentence comprehension: evidence from ERPs
    Zheng Ye
    Department of Psychology, Peking University, Beijing 100871, China
    Brain Res 1203:103-15. 2008
    ..reanalysis processes as a consequence of conflict between incompatible sentential representations in sentence comprehension. Using the event-related potential (ERP) technique, we examined the situation in which the sentential ..
  37. ncbi Bilateral speech comprehension reflects differential sensitivity to spectral and temporal features
    Jonas Obleser
    Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany
    J Neurosci 28:8116-23. 2008
    Speech comprehension has been shown to be a strikingly bilateral process, but the differential contributions of the subfields of left and right auditory cortices have remained elusive...
  38. ncbi Syntactic unification operations are reflected in oscillatory dynamics during on-line sentence comprehension
    Marcel Bastiaansen
    Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands
    J Cogn Neurosci 22:1333-47. 2010
    ..reflect the transient coupling and uncoupling of functional networks related to different aspects of language comprehension. In this work, we examine how sentence-level syntactic unification operations are reflected in the oscillatory ..
  39. ncbi Embodied language: a review of the role of the motor system in language comprehension
    Martin H Fischer
    School of Psychology, University of Dundee, Dundee, UK
    Q J Exp Psychol (Hove) 61:825-50. 2008
    ..To assess this motor resonance account of language comprehension, we first review recent developments in the literature on perception and action, with a view towards language ..
  40. pmc Thinking ahead: the role and roots of prediction in language comprehension
    Kara D Federmeier
    Department of Psychology, Program in Neuroscience, and the Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana Champaign, Champaign, Illinois 61820, USA
    Psychophysiology 44:491-505. 2007
    ..using event-related potentials to examine when and how sentence context information is used during language comprehension. Results suggest that, when it can, the brain uses context to predict features of likely upcoming items...
  41. ncbi Comprehension of human pointing gestures in young human-reared wolves (Canis lupus) and dogs (Canis familiaris)
    Zsófia Virányi
    Department of Ethology, Eotvos Lorand University, Budapest, Hungary
    Anim Cogn 11:373-87. 2008
    ..We assume that the high variability in the wolves' communicative behaviour might have provided a basis for selection during the course of domestication of the dog...
  42. ncbi Physical and perceptual factors shape the neural mechanisms that integrate audiovisual signals in speech comprehension
    HweeLing Lee
    Max Planck Institute for Biological Cybernetics, 72076 Tubingen, Germany
    J Neurosci 31:11338-50. 2011
    ..In conclusion, audiovisual speech comprehension emerges in an interactive process with the integration of auditory and visual signals being progressively ..
  43. ncbi Do people use language production to make predictions during comprehension?
    Martin J Pickering
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    Trends Cogn Sci 11:105-10. 2007
    We present the case that language comprehension involves making simultaneous predictions at different linguistic levels and that these predictions are generated by the language production system...
  44. ncbi A common system for the comprehension and production of narrative speech
    Malaka Awad
    Division of Neuroscience and Mental Health and Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom
    J Neurosci 27:11455-64. 2007
    ..Our hypothesis was that functional imaging in normal subjects would demonstrate the convergence of speech comprehension and production on high-order heteromodal and amodal cortical areas implicated in declarative memory functions...
  45. ncbi Retrieval and unification of syntactic structure in sentence comprehension: an FMRI study using word-category ambiguity
    Tineke M Snijders
    F C Donders Centre for Cognitive Neuroimaging, Nijmegen, The Netherlands
    Cereb Cortex 19:1493-503. 2009
    Sentence comprehension requires the retrieval of single word information from long-term memory, and the integration of this information into multiword representations...
  46. pmc Dissociating speech perception and comprehension at reduced levels of awareness
    Matthew H Davis
    Medical Research Council Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 7EF, United Kingdom
    Proc Natl Acad Sci U S A 104:16032-7. 2007
    ..MRI and the anesthetic agent propofol to assess the relationship among neural responses to speech, successful comprehension, and conscious awareness...
  47. ncbi Neural evidence that utterance-processing entails mentalizing: the case of irony
    Nicola Spotorno
    Laboratory L2C2, CNRS Université Lyon 1 FRE3406, 69675 Bron Cedex, France
    Neuroimage 63:25-39. 2012
    ..In the present fMRI investigation, we compare participants' comprehension of 18 target sentences as contexts make them either ironic or literal...
  48. ncbi Production, usage, and comprehension in animal vocalizations
    Robert M Seyfarth
    Department of Psychology and Biology, University of Pennsylvania, Philadelphia, 19104, USA
    Brain Lang 115:92-100. 2010
    In this review, we place equal emphasis on production, usage, and comprehension because these components of communication may exhibit different developmental trajectories and be affected by different neural mechanisms...
  49. ncbi How much anatomy is enough?
    Esther M Bergman
    Department of Anatomy Embryology, Maastricht University, Maastricht, The Netherlands
    Anat Sci Educ 1:184-8. 2008
    ..These factors appeared to outweigh the effects of disciplinary integration or whether the curriculum was problem-based or traditional...
  50. ncbi Prosodic phrasing is central to language comprehension
    Lyn Frazier
    Department of Linguistics, University of Massachusetts, Amherst, Massachusetts, 01003, USA
    Trends Cogn Sci 10:244-9. 2006
    ..Recent results suggest, however, that the global pattern of prosodic phrasing is what matters in sentence comprehension, not just the occurrence or size of a single local boundary...
  51. ncbi Informed consent: how much and what do patients understand?
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    Am J Surg 198:420-35. 2009
    ..We sought to evaluate the degree of patients' understanding of several aspects of the informed consent process for surgery and clinical research...
  52. ncbi HIV vaccine trials: critical issues in informed consent
    G Lindegger
    School of Psychology, University of Natal, Private Bag X01, Scottsville, Pietermaritzburg, 3209 South Africa
    S Afr J Sci 96:313-7. 2000
    ..Various contentious aspects of IC are examined, especially the problem of social desirability and of adequate comprehension. The need for sensitivity to cultural norms in implementing IC procedures is critically reviewed, and some of ..
  53. ncbi Sentence comprehension in autism: thinking in pictures with decreased functional connectivity
    Rajesh K Kana
    Center for Cognitive Brain Imaging, Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Brain 129:2484-93. 2006
    ..g. Addition, subtraction and multiplication are all math skills), the use of imagery is not essential to comprehension. Nevertheless, the autism group activated parietal and occipital brain regions associated with imagery for ..
  54. ncbi Wernicke's aphasia reflects a combination of acoustic-phonological and semantic control deficits: a case-series comparison of Wernicke's aphasia, semantic dementia and semantic aphasia
    Holly Robson
    Neuroscience and Aphasia Research Unit NARU, University of Manchester, Manchester, UK
    Neuropsychologia 50:266-75. 2012
    Wernicke's aphasia (WA) is the classical neurological model of comprehension impairment and, as a result, the posterior temporal lobe is assumed to be critical to semantic cognition...
  55. ncbi Validation of the Subjective Numeracy Scale: effects of low numeracy on comprehension of risk communications and utility elicitations
    Brian J Zikmund-Fisher
    VA Health Services Research and Development Center for Practice Management and Outcomes Research, VA Ann Arbor Healthcare System, Ann Arbor, Michigan, USA
    Med Decis Making 27:663-71. 2007
    ..In a companion article, the authors describe the Subjective Numeracy Scale (SNS), a self-assessment of numerical aptitude and preferences for numbers that correlates strongly with objective numeracy...
  56. pmc The neural correlates of emotional prosody comprehension: disentangling simple from complex emotion
    Lucy Alba-Ferrara
    Department of Psychiatry and Neuroscience, University of South Florida, Tampa, Florida, United States of America
    PLoS ONE 6:e28701. 2011
    Emotional prosody comprehension (EPC), the ability to interpret another person's feelings by listening to their tone of voice, is crucial for effective social communication...
  57. pmc Stimulus design is an obstacle course: 560 matched literal and metaphorical sentences for testing neural hypotheses about metaphor
    Eileen R Cardillo
    Department of Neurology, University of Pennsylvania, 3 West Gates, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Behav Res Methods 42:651-64. 2010
    ..the role of novelty, metaphor type, and sensory-motor grounding in determining the neural basis of metaphor comprehension. Supplemental data for this article may be downloaded from http://brm.psychonomic-journals...
  58. ncbi Quality of informed consent in cancer clinical trials: a cross-sectional survey
    S Joffe
    Department of Paediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA
    Lancet 358:1772-7. 2001
    ..Efforts to educate providers and participants about the underlying goals of clinical trials are needed...
  59. ncbi Predictors of comprehension during surgical informed consent
    Aaron S Fink
    Atlanta Veterans Affairs Medical Center, 1670 Clairmont Road, Decatur, GA 30033, USA
    J Am Coll Surg 210:919-26. 2010
    Patient comprehension during surgical informed consent remains problematic...
  60. ncbi Patient and physician factors predict patients' comprehension of health information
    Petra Lukoschek
    Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Room 1306, Belfer Building, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Patient Educ Couns 50:201-10. 2003
    ..not comprehend health information, little is known about patient and physician factors that influence lack of comprehension. To assess effectiveness of health information exchange, 19 physicians and 145 patients were given post-..
  61. ncbi Beta oscillations relate to the N400m during language comprehension
    Lin Wang
    Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands
    Hum Brain Mapp 33:2898-912. 2012
    ..ERPs/ERFs) and the event-related changes in EEG/MEG power that can be observed during sentence-level language comprehension is as yet unclear...
  62. ncbi Interventions to improve patient comprehension in informed consent for medical and surgical procedures: a systematic review
    Yael Schenker
    Department of Medicine, University of California, San Francisco, CA 94143, USA
    Med Decis Making 31:151-73. 2011
    ..Little is known about the effectiveness of interventions to improve comprehension or the extent to which such interventions address different elements of understanding in informed consent.
  63. pmc Repeated assessments of informed consent comprehension among HIV-infected participants of a three-year clinical trial in Botswana
    Lelia H Chaisson
    Berman Institute of Bioethics, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS ONE 6:e22696. 2011
    ..Few investigators measure participant comprehension of IC, while even fewer conduct interim assessments once a trial is underway.
  64. ncbi The weight of opinion on childhood obesity: recognizing complexity and supporting collaborative action
    Deanna Pagnini
    NSW Centre for Overweight and Obesity, University of Sydney
    Int J Pediatr Obes 4:233-41. 2009
    ..The study investigated similarities and differences in the perceptions of parents, adolescents, General Practitioners (GPs) and education professionals regarding childhood overweight and obesity...
  65. pmc The time course of action and action-word comprehension in the human brain as revealed by neurophysiology
    O Hauk
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 7EF, UK
    J Physiol Paris 102:50-8. 2008
    ..pivotal to determine the functional significance of motor areas in action recognition and action-word comprehension. Here, we review attempts to reveal the time course of these processes using neurophysiological methods (EEG, ..
  66. pmc Informed consent document improvement does not increase patients' comprehension in biomedical research
    Adeline Paris
    INSERM, CHU Grenoble, France
    Br J Clin Pharmacol 69:231-7. 2010
    ..whether the modification of the IC document by a working group or systematic improvement in its lexicosyntactic readability can improve comprehension of the written information given to patients participating in biomedical research.
  67. ncbi Distinction between the literal and intended meanings of sentences: a functional magnetic resonance imaging study of metaphor and sarcasm
    Hitoshi T Uchiyama
    Department of Education, Faculty of Regional Sciences, Tottori University, Tottori, Japan
    Cortex 48:563-83. 2012
    ..To delineate the neural substrates of pragmatic comprehension, we conducted functional magnetic resonance imaging (fMRI) with 20 normal adult volunteers...
  68. ncbi How vision is shaped by language comprehension--top-down feedback based on low-spatial frequencies
    Gerrit Hirschfeld
    Institute for Psychology, University of Munster, Munster, Germany
    Brain Res 1377:78-83. 2011
    Effects of language comprehension on visual processing have been extensively studied within the embodied-language framework...
  69. pmc The role of left and right hemispheres in the comprehension of idiomatic language: an electrical neuroimaging study
    Alice M Proverbio
    Department of Psychology, University of Milano Bicocca, 20126, Milan, Italy
    BMC Neurosci 10:116. 2009
    ..Word length, abstractness and frequency of use, sentence comprehensibility, familiarity and cloze probability were matched across classes...
  70. ncbi Ameliorating children's reading-comprehension difficulties: a randomized controlled trial
    Paula J Clarke
    University of York, York YO10 5DD, United Kingdom
    Psychol Sci 21:1106-16. 2010
    Children with specific reading-comprehension difficulties can read accurately, but they have poor comprehension...
  71. ncbi Rhythm's gonna get you: regular meter facilitates semantic sentence processing
    Kathrin Rothermich
    Max Planck Institute for Human Cognitive and Brain Sciences, Minerva Group Neurocognition of Rhythm in Communication, Leipzig, Germany
    Neuropsychologia 50:232-44. 2012
    ..languages such as German, this regularity functions as a powerful temporal and structural cue in speech comprehension. Recent evidence shows that it also interacts with higher level linguistic faculties such as syntax (Schmidt-..
  72. ncbi What is quality anyway? Performance reports that clearly communicate to consumers the meaning of quality of care
    Judith H Hibbard
    Department of Planning, Public Policy, and Management, University of Oregon, PO Box1209, Eugene, OR 97403 1209, USA
    Med Care Res Rev 67:275-93. 2010
    ..In this study, the authors determine the impact of providing a framework for understanding quality on the comprehension and salience of quality information...
  73. ncbi Disentangling the brain networks supporting affective speech comprehension
    Pierre Yves Hervé
    Univ Bordeaux, Groupe d Imagerie Neurofonctionnelle, UMR 5296, F 33000 Bordeaux, France
    Neuroimage 61:1255-67. 2012
    ..To confirm that these regions constitute a coherent network during affective speech comprehension, new event-related functional magnetic resonance imaging data were acquired, using the emotional and ..
  74. ncbi Comprehension of familiar and unfamiliar native accents under adverse listening conditions
    Patti Adank
    Donders Institute for Brain, Cognition, and Behavior, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, The Netherlands
    J Exp Psychol Hum Percept Perform 35:520-9. 2009
    This study aimed to determine the relative processing cost associated with comprehension of an unfamiliar native accent under adverse listening conditions...
  75. ncbi Semantic, factual, and social language comprehension in adolescents with autism: an FMRI study
    W B Groen
    Karakter, Child and Adolescent Psychiatry University Center, Karakter, 6525 GC Nijmegen, The Netherlands
    Cereb Cortex 20:1937-45. 2010
    ..high-functioning autistic participants was measured with functional magnetic resonance imaging during sentence comprehension and compared with that of twenty-six matched controls...
  76. ncbi A longitudinal investigation of early reading and language skills in children with poor reading comprehension
    Kate Nation
    Department of Experimental Psychology, University of Oxford, UK
    J Child Psychol Psychiatry 51:1031-9. 2010
    ..We used a longitudinal design to examine earlier reading and language skills in children identified as poor comprehenders in mid-childhood...
  77. ncbi Audiovisual integration during speech comprehension: an fMRI study comparing ROI-based and whole brain analyses
    Gregor R Szycik
    Department of Neuropsychology, University of Magdeburg, Magdeburg, Germany
    Hum Brain Mapp 30:1990-9. 2009
    Visual information (lip movements) significantly contributes to speech comprehension raising the question for the neural implementation of audiovisual (AV) integration during speech processing...
  78. ncbi The relations between children's communicative perspective-taking and executive functioning
    Elizabeth S Nilsen
    Department of Psychology, University of Waterloo, Waterloo, Ont, Canada N2L3G1
    Cogn Psychol 58:220-49. 2009
    ..of the perspective of their speaking partner to guide their communicative behaviors in both a production and comprehension task...
  79. ncbi Motor resonance as a function of narrative time: further tests of the linguistic focus hypothesis
    Rolf A Zwaan
    Department of Psychology, Erasmus University Rotterdam, PO Box 1738, NL 3000 DR Rotterdam, The Netherlands
    Brain Lang 112:143-9. 2010
    Neuroimaging and behavioral studies have revealed involvement of the brain's motor system in language comprehension. The Linguistic-Focus Hypothesis [Taylor, L. J., & Zwaan, R. A. (2008). Motor resonance and linguistic focus...
  80. pmc The role of the anterior temporal lobes in the comprehension of concrete and abstract words: rTMS evidence
    Gorana Pobric
    Neuroscience and Aphasia Research Unit, School of Psychological Sciences, University of Manchester, UK
    Cortex 45:1104-10. 2009
    ..The majority of SD patients (who have circumscribed atrophy of the anterior temporal lobes) have better comprehension of concrete than abstract words...
  81. pmc Neural development of networks for audiovisual speech comprehension
    Anthony Steven Dick
    Department of Neurology, The University of Chicago, IL, USA
    Brain Lang 114:101-14. 2010
    Everyday conversation is both an auditory and a visual phenomenon. While visual speech information enhances comprehension for the listener, evidence suggests that the ability to benefit from this information improves with development...
  82. pmc From language comprehension to action understanding and back again
    Pascale Tremblay
    Department of Neurology, The University of Chicago, Chicago, IL 60637, USA
    Cereb Cortex 21:1166-77. 2011
    A controversial question in cognitive neuroscience is whether comprehension of words and sentences engages brain mechanisms specific for decoding linguistic meaning or whether language comprehension occurs through more domain-general ..
  83. ncbi An amorphous model for morphological processing in visual comprehension based on naive discriminative learning
    R Harald Baayen
    Department of Linguistics, University of Alberta, Edmonton, Alberta, Canada
    Psychol Rev 118:438-81. 2011
    ..English phrasal paradigmatic effects modulating isolated word reading are reported and modeled, showing that the paradigmatic effects characterizing Serbian case inflection have crosslinguistic scope...
  84. ncbi The influence of multiple primes on bottom-up and top-down regulation during meaning retrieval: evidence for 2 distinct neural networks
    Carin Whitney
    Department of Psychology, University of York, York YO105DD, UK
    Cereb Cortex 19:2548-60. 2009
    ..They further imply a functional specialization of the LIPC along an anterior-posterior dimension...
  85. ncbi Disentangling syntax and intelligibility in auditory language comprehension
    Angela D Friederici
    Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
    Hum Brain Mapp 31:448-57. 2010
    Studies of the neural basis of spoken language comprehension typically focus on aspects of auditory processing by varying signal intelligibility, or on higher-level aspects of language processing such as syntax...
  86. ncbi Neural network of speech monitoring overlaps with overt speech production and comprehension networks: a sequential spatial and temporal ICA study
    Vincent van de Ven
    Department of Cognitive Neuroscience, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    Neuroimage 47:1982-91. 2009
    The neural correlates of speech monitoring overlap with neural correlates of speech comprehension and production...
  87. ncbi Bilateral brain processes for comprehending natural language
    Mark Jung-Beeman
    Department of Psychology, and Cognitive Brain Mapping Group, Northwestern University, 2029 Sheridan Road, Evanston, IL 60208 2710, USA
    Trends Cogn Sci 9:512-8. 2005
    b>Comprehension of natural language--stories, conversations, text--is very simple for those doing the comprehending and very complex for cognitive neuroscientists...
  88. ncbi Semantic ambiguity processing in sentence context: Evidence from event-related fMRI
    Monika Zita Zempleni
    Department of General Linguistics, University of Groningen, The Netherlands
    Neuroimage 34:1270-9. 2007
    ..The results indicate that a bilaterally distributed network supports semantic ambiguity comprehension: left (BA 45/44) and right (BA 47) inferior frontal gyri and left (BA 20/37) and right inferior/middle ..
  89. pmc Neural basis of irony comprehension in children with autism: the role of prosody and context
    A Ting Wang
    Department of Psychology, University of California, Los Angeles, CA, USA
    Brain 129:932-43. 2006
    ....
  90. ncbi Language in context: emergent features of word, sentence, and narrative comprehension
    Jiang Xu
    Language Section, Voice Speech and Language Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    Neuroimage 25:1002-15. 2005
    ..These results underscore the importance of studying language in an ecologically valid context, suggesting a neural model for the processing of discourse...
  91. ncbi Action comprehension in aphasia: linguistic and non-linguistic deficits and their lesion correlates
    Ayse Pinar Saygin
    Department of Cognitive Science, University of California, San Diego, 9500 Gilman Drive 0515, La Jolla, CA 92093 0515, USA
    Neuropsychologia 42:1788-804. 2004
    We tested aphasic patients' comprehension of actions to examine processing deficits in the linguistic and non-linguistic domains and their lesion correlates...
  92. ncbi A functional role for the motor system in language understanding: evidence from theta-burst transcranial magnetic stimulation
    Roel M Willems
    1Helen Wills Neuroscience Institute, University of California, Berkeley, USA
    Psychol Sci 22:849-54. 2011
    Does language comprehension depend, in part, on neural systems for action? In previous studies, motor areas of the brain were activated when people read or listened to action verbs, but it remains unclear whether such activation is ..
  93. ncbi Why organizations continue to create patient information leaflets with readability and usability problems: an exploratory study
    Iddo Gal
    Department of Human Services, University of Haifa, Mt Carmel, Eshkol Tower, Haifa 31905, Israel
    Health Educ Res 20:485-93. 2005
    ..It is suggested to adopt a broad ecological view of the environments in which patient education materials are created and deployed. Implications for practice and for future related research are discussed...
  94. pmc Action experience alters 3-month-old infants' perception of others' actions
    Jessica A Sommerville
    Department of Psychology and Institute for Learning and Brain Sciences, University of Washington, Seattle, Washington 98195, USA
    Cognition 96:B1-11. 2005
    ..These findings indicate that infants can rapidly form goal-based action representations and suggest a developmental link between infants' goal directed actions and their ability to detect goals in the actions of others...
  95. ncbi The neural integration of speaker and message
    Jos J A van Berkum
    Max Planck Institute for Psycholinguistics, Nijmegen, Netherlands
    J Cogn Neurosci 20:580-91. 2008
    ..According to our event-related potential results, language comprehension takes very rapid account of the social context, and the construction of meaning based on language alone cannot ..
  96. ncbi Elucidating the nature of deregulated semantic cognition in semantic aphasia: evidence for the roles of prefrontal and temporo-parietal cortices
    Krist A Noonan
    University of Manchester, Manchester, UK
    J Cogn Neurosci 22:1597-613. 2010
    ..Seven patients with SA were tested on four comprehension and naming tasks that directly manipulated the requirement for executive control in different ways...
  97. ncbi Right anterior superior temporal activation predicts auditory sentence comprehension following aphasic stroke
    Jenny Crinion
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, London, UK
    Brain 128:2858-71. 2005
    Previous studies have suggested that recovery of speech comprehension after left hemisphere infarction may depend on a mechanism in the right hemisphere...
  98. ncbi The relative timing of syntactic and semantic processes in sentence comprehension
    A D Friederici
    Max Planck Institute of Cognitive Neuroscience, PO Box 500 355, 04303 Leipzig, Germany
    Neuroreport 15:165-9. 2004
    ..The similarity of the ERP pattern for the pure syntactic and the double violation condition provides strong evidence for a functional primacy of initial syntactic over lexical-semantic processes...
  99. ncbi Interplay between syntax and semantics during sentence comprehension: ERP effects of combining syntactic and semantic violations
    Peter Hagoort
    University of Nijmegen
    J Cogn Neurosci 15:883-99. 2003
    ..Overall, the results reveal an asymmetry in the interplay between syntax and semantics during on-line sentence comprehension.
  100. ncbi Comprehension of human pointing gestures in horses (Equus caballus)
    Katalin Maros
    Department of Organic Agriculture and Animal Welfare, Szent Istvan University, Páter Károly u 1, 2103, Godollo, Hungary
    Anim Cogn 11:457-66. 2008
    ..rely spontaneously on those cues that could have a stimulus or local enhancement effect, but the possible comprehension of the distal momentary pointing remained unclear...
  101. pmc Grasping the intentions of others with one's own mirror neuron system
    Marco Iacoboni
    Ahmanson Lovelace Brain Mapping Center, Neuropsychiatric Institute, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    PLoS Biol 3:e79. 2005
    ..To ascribe an intention is to infer a forthcoming new goal, and this is an operation that the motor system does automatically...

Research Grants80

  1. Improving Self-Reports About High Risk Sexual Behavior
    Diane Binson; Fiscal Year: 2010
    ..Scientific models of the survey question-answer process specify question comprehension as a necessary precursor to obtaining a response that is as error-free as possible...
  2. Enhanced Multimedia Telehealth for Hearing Disabilities
    Yunxin Zhao; Fiscal Year: 2005
    ..driven array of adaptations to current telehealth systems that will facilitate speech and sign language comprehension. The project will achieve three aims: 1) It will enhance language comprehension by developing a real-time ..
  3. SOME DETERMINANTS OF SPEECH PERCEPTION
    Joanne Miller; Fiscal Year: 2007
    ..applicant): The overall objective of the proposed research is to increase our understanding of spoken language comprehension. The research focuses specifically on the very early stages of comprehension, during which the listener ..
  4. Regulation of B Cell Function by Membrane-Cytoskeletal Remodeling
    Neetu Gupta; Fiscal Year: 2012
    ..Ultimately, our research will facilitate better comprehension of immunological disorders that result from perturbation of signaling pathways and cellular architecture...
  5. Transforming PCI Informed Consent into an Evidence-based Decision-making Tool
    John A Spertus; Fiscal Year: 2010
    ..eliciting informed consent from patients undergoing percutaneous coronary intervention (PCI) on patients'comprehension of procedural risks/benefits and upon clinicians'use of effective strategies to minimize the risk of ..
  6. Thrombospondin 4 A1
    JOHN W LAWLER; Fiscal Year: 2010
    A detailed comprehension of the role of the thrombospondins (TSPs), including cartilage oligomeric matrix protein (COMP), in the regulation of extracellular matrix (ECM) structure and cellular behavior during tissue genesis and repair is ..
  7. PTIP as an epigenetic regulator in male meiosis
    Guo Zhang Zhu; Fiscal Year: 2013
    ..Despite recent progress, our comprehension of the dynamic epigenome in developing male germ cells remains largely to be defined...
  8. Integration of mucosal immune responses through the enteric nervous system
    DANIEL S MUCIDA; Fiscal Year: 2013
    ..unappreciated multidirectional interactions between the immune system and the nervous system, enhancing our comprehension of gut immunity, opening new avenues for the design of alternative treatment for intestinal infections and ..
  9. Integration of PR and FoxO Signaling in Pituitary Gonadotropes
    Varykina G Thackray; Fiscal Year: 2010
    ..In Specific Aim 2, comprehension of FoxO1 function in the pituitary gonadotrope will be expanded using genetic analysis of conditional null ..
  10. Phosphorylation Events During Sperm Capacitation
    PABLO EDUARDO VISCONTI; Fiscal Year: 2013
    ..RELEVANCE: Difficulties in earlier efforts to fertilize mammalian eggs in vitro were due mainly to a lack of comprehension of sperm physiology...
  11. GRAFT REJECTION AND DIRECT VERSUS INDIRECT RECOGNITION
    PETER SCOTT HEEGER; Fiscal Year: 2013
    ..The results of the studies will improve comprehension of immune mechanisms that result in allograft injury, specifically addressing the impact of locally activated ..
  12. Effect of MIP-1 delta on Osteoclast Development and Pathological Bone Resorption
    Scott L Kominsky; Fiscal Year: 2010
    ..Despite advances in our comprehension of the bone remodeling process, the mechanisms responsible for pathological bone loss initiated by skeletal ..
  13. Physiologic Regulation of Hematopoiesis by Notch
    Nadia Carlesso; Fiscal Year: 2011
    ..A better comprehension of the events that coordinate cell proliferation and differentiation during normal hematopoiesis is crucial ..
  14. Mechanisms used by skin dendritic cells to induce regulatory T cells
    Juliana Idoyaga; Fiscal Year: 2013
    ..A detailed comprehension of the mechanisms of DC-mediated T reg induction will help to understand the events that lead to the ..
  15. Role of miR-8 and Ena in Synaptic Structure and Function
    CARLOS MANUEL LOYA; Fiscal Year: 2010
    ..the molecular components involved in the establishment of appropriate synaptic contacts is important for our comprehension of these disease states, and potentially for the discovery of drug targets and therapeutics...
  16. TripleTOF 5600 Hybrid Mass Spectrometer
    Hanno Steen; Fiscal Year: 2012
    ..of cytokines and receptors on sensory neurons associated with inflammatory pain and advancing the comprehension of the minimal cell cycle and the systems biochemistry of multisite phosphorylation...
  17. Effects of expectation on gustatory cortical activity
    Alfredo Fontanini; Fiscal Year: 2013
    ..The comprehension of how the brain responds to the expectation of tastes will shed light on the complexities of food selection ..
  18. Genetic and Transcriptional Control of Spleen Development
    Licia Selleri; Fiscal Year: 2013
    ..Lastly, our studies aspire to provide a better comprehension of the pathogenesis of congenital asplenia, as we put forth the prerequisite basic genetic background towards ..
  19. Study of Dopamine Transporter, a Direct Downstream Effector of Goalpha Signaling
    Anjali Rao; Fiscal Year: 2011
    ..A better comprehension of molecular mechanisms of DAT endocytic trafficking is not only crucial for understanding normal DA ..
  20. Role of Peroxisome Proliferation in Leptin Resistance
    Sabrina Diano; Fiscal Year: 2013
    ..In particular, a comprehension of the fine cellular interplay and intracellular mechanisms that enable appropriate hypothalamic and ..
  21. Blood-to-CNS Drug Uptake in Pain
    THOMAS PAUL DAVIS; Fiscal Year: 2013
    ..A clear comprehension of biological mechanisms involved in drug transport across the BBB is essential to clarify CNS uptake of ..
  22. Immune evasion in a humanized mouse model of HHV-6 infection
    Amy W Hudson; Fiscal Year: 2013
    ..viruses is essential: not only will greater knowledge of these viral mechanisms lead to a more thorough comprehension of how these viruses have such great success in evading the host immune response, but a greater understanding ..
  23. Multi-Center Assessment of Health Literacy and Oral Health
    Mark D Macek; Fiscal Year: 2013
    ..At the heart of that understanding is knowing the ways that different health literacy skills (e.g., reading comprehension, numeracy, conceptual knowledge) work individually and as a group to support oral healthcare decision making ..
  24. FUNCTIONAL ORGANIZATION OF PRIMARY AUDITORY CORTEX
    Christoph E Schreiner; Fiscal Year: 2013
    ..Examples of central auditory consequences of peripheral hearing disorders are a reduction of speech comprehension for patients even if they that have well-fitted hearing aids, or the difficulty to understand speech in ..
  25. Autophagy, Mitochondria and Aging in Drosophila
    Amalia Icreverzi; Fiscal Year: 2012
    ..A fundamental understanding of how mitochondria are turned over is critical to enhance our comprehension of aging, and may provide insights into the development of therapies...
  26. Regulation, signaling, and dynamics of glucan phosphatases.
    Matthew S Gentry; Fiscal Year: 2013
    ..Completion of this work will yield a better comprehension of these complex events and will produce therapeutic insights for epilepsy and neurodegeneration.
  27. The ILK/PINCH/Parvin complex in renal tubulogenesis
    Roy Zent; Fiscal Year: 2013
    ..Understanding this basic cell biological process will help with our comprehension of the pathophysiology of congenital renal diseases resulting in abnormal tubule formation as well as how ..
  28. Explore fundamental aspects of neurotransmission with multifunctional nanosensor
    Qi Zhang; Fiscal Year: 2011
    ..and precise measurement obstructs further investigation of synaptic vesicles and thus impedes a complete comprehension of such mutual modulation...
  29. Quality of Informed Consent for Adult-to-Adult Living Donor Liver Transplantation
    Elisa J Gordon; Fiscal Year: 2012
    ..However, current practice does not entail any formal assessment of a donor's comprehension and no tools exist to formally assess the adequacy of informed consent in this or any other clinical contexts...
  30. Informed Consent in Pediatric Phase I Cancer Trials
    Eric D Kodish; Fiscal Year: 2011
    The primary goal of this research is to understand communication, comprehension and decision-making in Phase I childhood cancer trials...
  31. Brain Mechanisms in Pediatric Bipolar Disorder and Attention Deficit Hyperactivit
    Mani N Pavuluri; Fiscal Year: 2010
    ..Mechanistic comprehension of the neural circuitry function will enhance our understanding of the dimensional functions of affect and ..
  32. DIFFERENTIAL DIAGNOSIS IN LEARNING DISABILITIES
    Richard K Olson; Fiscal Year: 2013
    ..the identification, characterization, validation and amelioration of reading disabilities (both word-level and comprehension), writing disabilities (both writing mechanics and composition), and ADHD, the most prevalent and often co-..
  33. Modeling PCa Bone Metastasis: Dual Role of E-selectin Ligands and Integrins
    STEVEN RUSSELL BARTHEL; Fiscal Year: 2012
    ..Of note, 80- 90% of these patients presented with bone metastasis. Unfortunately, our comprehension of how bone metastasis is initiated is ill-defined...
  34. Speech Perception Assessment and Training System for Aphasia Rehabilitation
    James D Miller; Fiscal Year: 2010
    ..This has the promise of improving language comprehension skills more broadly as speech-perception impairments appear to have a cascading effect on higher levels of ..
  35. Impact of PrEP Messaging on Comprehension, Acceptability, and Risk Among MSM
    Sarit A Golub; Fiscal Year: 2013
    ..and cumulative impact of four elements of PrEP messaging - modality, frame, specificity, and messenger - on comprehension and acceptability of PrEP as a biomedical prevention strategy;(2) Estimate the impact of each of these factors ..
  36. Studies of Natural SIV Infection of Sooty Mangabeys
    Guido Silvestri; Fiscal Year: 2013
    ..We believe that these studies will improve our comprehension of AIDS pathogenesis in humans and that this knowledge will ultimately translate in better prevention and ..
  37. Mechanisms of Pbx-directed Genetic &Transcriptional Control of Limb Development
    Licia Selleri; Fiscal Year: 2013
    ..Broadly, given the involvement of human HOX genes in leukemias and solid tumors, our studies will inform general comprehension of HOX regulation also in human neoplasia.
  38. Medtable: An EMR Strategy to Promote Patient Medication Understanding and Use
    Daniel G Morrow; Fiscal Year: 2012
    ..g., provide complete information, check patient comprehension);H2) Patients in the intervention condition will be more satisfied with communication about medication...
  39. Predicting language outcomes from early processing efficiency in preterm children
    Anne Fernald; Fiscal Year: 2013
    ..mos on a series of increasingly challenging, but developmentally appropriate, assessments of online language comprehension and on standardized offline tests of cognition and language...
  40. Corepressor Regulation of Nuclear Receptor Action
    Anthony N Hollenberg; Fiscal Year: 2013
    ..The completion of these three Aims will allow for greater comprehension of how modulation of co-repressor signaling in vivo alters key metabolic pathways...
  41. Dissecting the genetic underpinnings of essential tremor
    Coro Paisan-Ruiz; Fiscal Year: 2013
    ..In addition, we strongly believe that the identification of novl tremor genes will greatly contribute to the comprehension of other neurodegenerative diseases such as Parkinson's disease, as having ET increases the risk for ..
  42. A Multicultural, Multilingual HPV Vaccine Education DVD for Diverse Populations
    Armando Valdez; Fiscal Year: 2010
    ..parents of girls 9-17 old, (2) identify cultural values, beliefs, and practices that influence attention, comprehension, perception and evaluation of HPV vaccine information intended to inform an immunization decision, (3) ..
  43. The PFT Intervention: Linking triply-diagnosed inpatients to community care
    Michael B Blank; Fiscal Year: 2013
    ..participants to implement the adherence component of PFT using approaches tailored to the communication and comprehension of the person that includes memory aids, education regarding side effects and other treatment aspects, ..
  44. DISCLOSING A DEMENTIA DIAGNOSIS: ANALYSIS OF A TRIADIC HEALTHCARE ENCOUNTER
    Brian D Carpenter; Fiscal Year: 2010
    ..the diagnostic disclosure encounter that predict subsequent depression, anxiety, satisfaction, and diagnostic comprehension in patients and companions...
  45. The effects of aging and hearing loss on human auditory cortex
    David L Woods; Fiscal Year: 2013
    ..To evaluate the behavioral relevance of these changes we have developed new tests of speech comprehension in noise and auditory short- term verbal memory and found that these abilities are compromised by aging, ..
  46. Regulation of cardiac morphogenesis by Nkx genes
    KIMARA L TARGOFF; Fiscal Year: 2010
    ..However, comprehension of the underlying cellular and molecular mechanisms regulated by NKX2-5 is extremely limited...
  47. HIV Prevention Messages Targeting Latino MSM
    Maria Rosa Solorio; Fiscal Year: 2013
    ..We will launch the HIV prevention PSAs onto website and radio and evaluate messages acceptability, comprehension and recall, and attitude strength;message impact on "intentions" towards HIV testing and condom use and on ..
  48. Neuroscience Advanced Predoctoral Institutional Training Grant
    Jerome N Sanes; Fiscal Year: 2012
    ..training at all levels with a strong foundation in core concepts, skills, methodologies, and advanced comprehension of the scientific literature...
  49. HPV Vaccine Education Intervention for Medically Underserved High-risk Population
    Armando Valdez; Fiscal Year: 2013
    ..specific themes, message elements and communication strategies for an intervention that enhances patient comprehension and evaluation of the risks and benefits of the vaccine, (3) identify cultural values, beliefs, and practices ..
  50. Measuring Prisoners'Voluntary Consent to Clinical Research for Opioid Dependence
    PAUL PASQUALE CHRISTOPHER; Fiscal Year: 2013
    ..definition and preliminary set of instrument items, and d) pilot testing the instrument for readability and comprehension. Establishing the instrument's construct validity (Aim 2) will be achieved by evaluating concept validity ..
  51. Improving decision making for patients with prolonged mechanical ventilation
    CHRISTOPHER ETHAN COX; Fiscal Year: 2013
    ..quality, defined as clinician-surrogate concordance for prognosis, quality of communication, and medical comprehension;(2) surrogates'psychological distress;and (3) patients'health care utilization...
  52. NEURAL NETWORKS FOR SPEECH PERCEPTION IN NOISE
    Lee M Miller; Fiscal Year: 2010
    ..neural network analyses test how interactions among brain regions accommodate degraded speech and improve comprehension. Our specific AIMS are to identify the neural networks mediating speech perception in noise, when ..
  53. Risk Communication for Environmental Exposure
    Brian J Zikmund Fisher; Fiscal Year: 2010
    ..This study seeks to: 1) examine comprehension, retention, and risk perception of messages, and change in behavior among residents who participated in a ..
  54. EFFECTS OF ASYMMETRIC HEARING IN ACOUSTIC LISTENERS AND COCHLEAR IMPLANT USERS
    Jill B Firszt; Fiscal Year: 2013
    ..We predict that compensating for degraded speech comprehension in noise involves greater activation of cognitive centers in temporo-parietal, inferior and dorsolateral ..
  55. Reducing HIV Disparities: Sexual Concurrency Communication for HIV Prevention amo
    Michele Peake Andrasik; Fiscal Year: 2010
    ..will launch HIV prevention concurrency messaging and evaluate acceptability and impact, including message comprehension and recall (1-month post recall among n=30 African-Americans and n=30 Kenyans and Ethiopians), intention, and ..
  56. Vocabulary Support for Consumer Health Informatics
    Qing Zeng; Fiscal Year: 2010
    ..project will concentrate on improving consumer-term to health-concept mapping, and later work will give attention to the problem of selecting the best form of a concept for consumer health information comprehension and retrieval.
  57. Effects of Parkinson's Disease on Perception, Cognition, and Gait
    Alice Cronin-Golomb; Fiscal Year: 2013
    ..of daily functions that is affected in PD is visuospatial ability, which enables the perceptual and cognitive comprehension and navigation of the visual environment...
  58. Processing Streams in the Cerebral Cortex
    Josef P Rauschecker; Fiscal Year: 2013
    ..The studies are also relevant for disorders such as dyslexia and autism, which include problems in language comprehension or ability for social communication...
  59. Aging and speech perception in complex listening environments
    Karen S Helfer; Fiscal Year: 2013
    ..evaluation and treatment methods that focus on both the sensory and cognitive age-related changes that mediate comprehension in these situations...
  60. Analysis of Clustered Protocadherin Function in Mammalian Neurodevelopment
    Lindsay A Schwarz; Fiscal Year: 2013
    ..full understanding of the molecules mediating synaptic partner choice is crucial for make advancements in our comprehension and treatment of these diseases...
  61. Isolation and proteomic analysis of the sperm annulus
    DR PATRICIA L MORRIS; Fiscal Year: 2010
    ..Understanding the vital role the annulus plays in sperm function will advance our comprehension of how these mechanisms work together to make a sperm cell become a functional gamete...
  62. Human polymorphic variance in the Dectin-1 signaling pathway
    ANDREA JEAN WOLF; Fiscal Year: 2010
    ..The absence of a similar set of genetic tools in humans has hampered our comprehension of Dectin-1's significance during fungal infection in humans...
  63. SULT4A1 Function in Zebrafish Development
    Charles N Falany; Fiscal Year: 2013
    ..A more complete comprehension of SULT4A1 function and activity in zebrafish, as elaborated by the following specific aims, will provide ..
  64. Optimizing Kidney Transplant Patients'Informed Consent for Increased Risk Donors
    Elisa J Gordon; Fiscal Year: 2013
    ..The objective of this study is to increase KT candidates'comprehension about IR kidneys necessary for providing informed consent...
  65. FUNCTIONAL NEUROANATOMY OF NORMAL AND IMPAIRED LANGUAGE
    Steven L Small; Fiscal Year: 2012
    ..An important source of information for language comprehension comes from the perception of action, including the movements of the mouth and hands...
  66. AMPLIFICATION, MIDDLE EAR PATHOLOGY AND ACADEMIC SUCCESS
    NICKOLA NELSON; Fiscal Year: 1993
    ..study aims to explore the effects of classroom sound field amplification on phonological awareness, concept comprehension, and teacher ratings of educational risk among first grade children with and without middle ear pathology (..
  67. Improving the language and literacy skills of Spanish-English Bilingual Kindergar
    MARIELA PAEZ; Fiscal Year: 2011
    ..and two cores proposed in this program project is a shared model for the development of word knowledge and comprehension skills, the approaches used to promote word knowledge, and the methods used in the conduct of the research...
  68. Theoretically based treatment for sentence comprehension deficits in aphasia
    Swathi Kiran; Fiscal Year: 2009
    ..Diagnosis and treatment of sentence comprehension deficits in patients with aphasia is one area where disparities continue to exist even though this topic is of ..
  69. EYE MOVEMENTS AND LINGUISTIC COMPREHENSION IN APHASIA
    Brooke Hallowell; Fiscal Year: 2002
    ..that may impair their ability to respond, or to respond correctly, when traditional tests of linguistic comprehension are administered...
  70. Simulation Studies of Parental Permission and Childrens Assent for Research
    Holly Antal; Fiscal Year: 2009
    ..e. comprehension, satisfaction, decision-making) that reflect the quality of the PPA process...
  71. Optogenetic analysis of circuits for vocal recognition
    Richard Mooney; Fiscal Year: 2009
    ..that support vocal perception is essential for treatment of the broad array of pathologies that affect speech comprehension, such as aphasic stroke, autism and developmental dyslexia...
  72. Computerized HIV Vaccine Trial Assent: Will It Improve Adolescent Comprehension?
    Diane Blake; Fiscal Year: 2009
    ..Next, we will develop comprehension items for each element of informed assent...
  73. Eyetracking Comprehension Assessment System (ECAS): Improving Validity of Compreh
    Brooke Hallowell; Fiscal Year: 2010
    ..of this project is to develop and test the feasibility of an eyetracking system for assessment of language comprehension in people with stroke and brain injury...
  74. COGNITIVE LINKAGE TO BRAIN FUNCTION
    MARCEL JUST; Fiscal Year: 2001
    ..will trace ongoing mental processes by tracking eye fixations and other behavioral measures during the comprehension of sentences, examining the role of working memory in comprehension...
  75. Language and Literacy Intervention for Spanish English bilinguals with SLI
    Lisa M Bedore; Fiscal Year: 2010
    ..that direct instruction in key preliteracy skills (phonological awareness, text decoding, and text comprehension) is an effective intervention strategy leading to long lasting change in literacy skills...
  76. PROJECT 4 - HEALTH LITERACY AND CANCER PREVENTION;DO PEOPLE UNDERSTAND WHAT THEY
    KATHLEEN MICHELE MAZOR; Fiscal Year: 2011
    This application proposes to develop a test to assess comprehension of oral (i.e...
  77. The Connecticut Longitudinal Study in the Fourth Decade
    Sally E Shaywitz; Fiscal Year: 2010
    ..for: "basic research onthe neurobiological underpinnings of reading fluency, vocabulary development, reading comprehension..." and "imaging studies that use a variety of imaging modalities (e.g...
  78. Communicating probabilities through interactive computer graphics
    Rita Kukafka; Fiscal Year: 2007
    ..People of all educational levels are subject to cognitive biases when thinking about probabilities, and comprehension is further impaired by low educational level or numeracy...
  79. Indices of Lexical Access During Idiom Comprehension
    Kathleen Brumm; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): This project examines spoken language comprehension in individuals with aphasia, a language disorder acquired subsequent to stroke...
  80. Individual differences in memory storage and retrieval during reading comprehensi
    Julie A Van Dyke; Fiscal Year: 2010
    Reading and language comprehension requires the ability to identify relationships between linguistic units that are frequently non-adjacent. This means that comprehenders must be able to store partially interpreted material (e.g...