efficiency

Summary

Summary: Ratio of output to effort, or the ratio of effort produced to energy expended.

Top Publications

  1. ncbi Using the World Health Organization Health and Work Performance Questionnaire (HPQ) to evaluate the indirect workplace costs of illness
    Ronald C Kessler
    Department of Health Care Polity, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Occup Environ Med 46:S23-37. 2004
  2. doi Stone tool use by adult wild bearded capuchin monkeys (Cebus libidinosus). Frequency, efficiency and tool selectivity
    Noemi Spagnoletti
    Istituto di Scienze e Tecnologie della Cognizione, Consiglio Nazionale delle Ricerche, Via Aldrovandi 16B, 00161 Rome, Italy
    J Hum Evol 61:97-107. 2011
  3. ncbi The health and productivity cost burden of the "top 10" physical and mental health conditions affecting six large U.S. employers in 1999
    Ron Z Goetzel
    Institute for Health and Productivity Studies, Cornell University, USA
    J Occup Environ Med 45:5-14. 2003
  4. ncbi Precision and accuracy in measuring absence from work as a basis for calculating productivity costs in The Netherlands
    J L Severens
    Department of Medical Technology Assessment, University of Nijmegen, The Netherlands
    Soc Sci Med 51:243-9. 2000
  5. doi Obesity and presenteeism: the impact of body mass index on workplace productivity
    Donna M Gates
    College of Nursing, and Department of Environmental Health, University of Cincinnati, 3110 Vine Street, Cincinnati, OH 45221, USA
    J Occup Environ Med 50:39-45. 2008
  6. doi Measuring and valuing productivity loss due to poor health: A critical review
    Wei Zhang
    Centre for Health Evaluation and Outcome Sciences, St Paul s Hospital, and School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada
    Soc Sci Med 72:185-92. 2011
  7. pmc Control of translation efficiency in yeast by codon-anticodon interactions
    Daniel P Letzring
    Department of Biochemistry and Biophysics, University of Rochester Medical School, Rochester, New York 14642, USA
    RNA 16:2516-28. 2010
  8. doi DNA damage in human spermatozoa is highly correlated with the efficiency of chromatin remodeling and the formation of 8-hydroxy-2'-deoxyguanosine, a marker of oxidative stress
    Geoffry N De Iuliis
    ARC Centre of Excellence in Biotechnology and Development and Hunter Medical Research Institute, Discipline of Biological Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
    Biol Reprod 81:517-24. 2009
  9. doi The value of productivity: human-capital versus friction-cost method
    W B van den Hout
    Leiden University Medical Centre, Department of Medical Decision Making, J10 S, PO Box 9600, 2300 RC Leiden, The Netherlands
    Ann Rheum Dis 69:i89-91. 2010
  10. pmc Telephone screening, outreach, and care management for depressed workers and impact on clinical and work productivity outcomes: a randomized controlled trial
    Philip S Wang
    Division of Services and Intervention Research, National Institute of Mental Health, Rockville, Maryland, USA
    JAMA 298:1401-11. 2007

Detail Information

Publications376 found, 100 shown here

  1. ncbi Using the World Health Organization Health and Work Performance Questionnaire (HPQ) to evaluate the indirect workplace costs of illness
    Ronald C Kessler
    Department of Health Care Polity, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Occup Environ Med 46:S23-37. 2004
    ..Innovative data analysis strategies are described to address these problems...
  2. doi Stone tool use by adult wild bearded capuchin monkeys (Cebus libidinosus). Frequency, efficiency and tool selectivity
    Noemi Spagnoletti
    Istituto di Scienze e Tecnologie della Cognizione, Consiglio Nazionale delle Ricerche, Via Aldrovandi 16B, 00161 Rome, Italy
    J Hum Evol 61:97-107. 2011
    ..stone tools more frequently than females, (2) males crack high resistance nuts more frequently than females, (3) efficiency at opening a food by percussive tool use varies according to the resistance of the encased food, (4) heavier ..
  3. ncbi The health and productivity cost burden of the "top 10" physical and mental health conditions affecting six large U.S. employers in 1999
    Ron Z Goetzel
    Institute for Health and Productivity Studies, Cornell University, USA
    J Occup Environ Med 45:5-14. 2003
    ..Implications for employers and health plans in examining the health and productivity consequences of common health conditions are discussed...
  4. ncbi Precision and accuracy in measuring absence from work as a basis for calculating productivity costs in The Netherlands
    J L Severens
    Department of Medical Technology Assessment, University of Nijmegen, The Netherlands
    Soc Sci Med 51:243-9. 2000
    ..We recommend using a recall period of no more than 2 months...
  5. doi Obesity and presenteeism: the impact of body mass index on workplace productivity
    Donna M Gates
    College of Nursing, and Department of Environmental Health, University of Cincinnati, 3110 Vine Street, Cincinnati, OH 45221, USA
    J Occup Environ Med 50:39-45. 2008
    ..To examine whether obesity is associated with increased presenteeism (health-related limitations at work)...
  6. doi Measuring and valuing productivity loss due to poor health: A critical review
    Wei Zhang
    Centre for Health Evaluation and Outcome Sciences, St Paul s Hospital, and School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada
    Soc Sci Med 72:185-92. 2011
    ..We conclude by proposing a generic measure instead of a disease-specific measure and discuss important perspective related issues...
  7. pmc Control of translation efficiency in yeast by codon-anticodon interactions
    Daniel P Letzring
    Department of Biochemistry and Biophysics, University of Rochester Medical School, Rochester, New York 14642, USA
    RNA 16:2516-28. 2010
    ..The choice of synonymous codons used to encode a polypeptide contributes to substantial differences in translation efficiency between genes...
  8. doi DNA damage in human spermatozoa is highly correlated with the efficiency of chromatin remodeling and the formation of 8-hydroxy-2'-deoxyguanosine, a marker of oxidative stress
    Geoffry N De Iuliis
    ARC Centre of Excellence in Biotechnology and Development and Hunter Medical Research Institute, Discipline of Biological Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
    Biol Reprod 81:517-24. 2009
    ..These results clearly highlight the importance of oxidative stress in the induction of sperm DNA damage and carry significant implications for the clinical management of this condition...
  9. doi The value of productivity: human-capital versus friction-cost method
    W B van den Hout
    Leiden University Medical Centre, Department of Medical Decision Making, J10 S, PO Box 9600, 2300 RC Leiden, The Netherlands
    Ann Rheum Dis 69:i89-91. 2010
    ..If productivity is given less weight by excluding productivity costs or by using the friction-cost method, then currently, biological agents are probably too expensive...
  10. pmc Telephone screening, outreach, and care management for depressed workers and impact on clinical and work productivity outcomes: a randomized controlled trial
    Philip S Wang
    Division of Services and Intervention Research, National Institute of Mental Health, Rockville, Maryland, USA
    JAMA 298:1401-11. 2007
    ..Organized depression care programs significantly improve treatment quality, but employer purchasers have been slow to adopt these programs based on lack of evidence for cost-effectiveness from their perspective...
  11. ncbi Reductions in individual work productivity associated with type 2 diabetes mellitus
    Jill E Lavigne
    Department of Community and Preventive Medicine, University of Rochester School of Medicine, 601 Elmwood Avenue, Box 644, Rochester, New York 14642, USA
    Pharmacoeconomics 21:1123-34. 2003
    ..Chronic diseases and their treatments may cause symptoms that impair performance but are too mild to affect outcome measures such as absences and workforce exit...
  12. ncbi Progress in phage display: evolution of the technique and its application
    Tomaz Bratkovic
    Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia
    Cell Mol Life Sci 67:749-67. 2010
    ..Novel display formats, innovative library designs and screening strategies are discussed. I will also briefly review some recent uses of the technology to illustrate its incredible versatility...
  13. ncbi Missing... presumed at random: cost-analysis of incomplete data
    Andrew Briggs
    Health Economics Research Centre, University of Oxford, Institute of Health Sciences, Headington, UK
    Health Econ 12:377-92. 2003
    ....
  14. ncbi Breast cancer survival, work, and earnings
    Cathy J Bradley
    Department of Medicine, College of Human Medicine, Michigan State University, East Lansing 48824, USA
    J Health Econ 21:757-79. 2002
    ..Our research points to heterogeneous labor market responses to breast cancer, and shows that breast cancer does not appear to be debilitating for women who remain in the work force...
  15. pmc "Surgery is certainly one good option": quality and time-efficiency of informed decision-making in surgery
    Clarence Braddock
    Stanford University School of Medicine, 251 Campus Drive, MC 5475, Stanford, CA 94305 5475, USA
    J Bone Joint Surg Am 90:1830-8. 2008
    ..This study was designed to explore the quality of informed decision-making in orthopaedic practice and to identify excellent time-efficient examples with older patients...
  16. pmc Validity of the work productivity and activity impairment questionnaire--general health version in patients with rheumatoid arthritis
    Wei Zhang
    Centre for Health Evaluation and Outcome Sciences, St Paul s Hospital, 620 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    Arthritis Res Ther 12:R177. 2010
    ..The present study's purpose is to evaluate the construct validity of the WPAI-general health version among RA patients and its ability to differentiate between RA patients with varying health status...
  17. ncbi Medical comorbidity and rehabilitation efficiency in geriatric inpatients
    L Patrick
    SCO Health Service, Ottawa, Ontario, Canada
    J Am Geriatr Soc 49:1471-7. 2001
    ..medical comorbidity in geriatric rehabilitation patients and investigate its relationship to rehabilitation efficiency. DESIGN: Prospective, multivariate, within-subject design...
  18. pmc The clinical and occupational correlates of work productivity loss among employed patients with depression
    Debra Lerner
    The Health Institute, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, MA 02111, USA
    J Occup Environ Med 46:S46-55. 2004
    ..05 in 3/5 models). The Work Limitations Questionnaire can help employers to reduce productivity loss by identifying health and productivity improvement priorities...
  19. ncbi Safety and efficiency of novel sonic scaler tips in vitro
    Gregor J Petersilka
    Department of Periodontology, University of Munster, Germany
    J Clin Periodontol 30:551-5. 2003
    The aim of the study was to evaluate a novel sonic scaler tip for subgingival root surface instrumentation combining high efficiency in calculus removal with minimized risk of root damage through subgingival debridement.
  20. ncbi Non-caring encounters at an emergency care unit--a life-world hermeneutic analysis of an efficiency-driven organization
    Maria Nystrom
    Sunnerviksgatan 14, Gothenburg 418 72, Sweden
    Int J Nurs Stud 40:761-9. 2003
    ..The interpretative analysis reveals an adaptation to organisational demands for efficiency, on the part of both nurses and patients...
  21. pmc The burden of chronic obstructive pulmonary disease among employed adults
    Marco daCosta Dibonaventura
    Health Sciences Practice, Kantar Health, New York, NY 10010, USA
    Int J Chron Obstruct Pulmon Dis 7:211-9. 2012
    ..To examine quality of life, work productivity, and health care resource use among employed adults ages 40-64 years with chronic obstructive pulmonary disease (COPD) in the United States...
  22. ncbi Efficiency, power, and entropy in event-related fMRI with multiple trial types. Part II: design of experiments
    Thomas T Liu
    Center for Functional Magnetic Resonance Imaging, University of California San Diego, La Jolla, CA, USA
    Neuroimage 21:401-13. 2004
    ..an experimental design for functional magnetic resonance imaging (fMRI) can be characterized by its estimation efficiency, which is the ability to make an estimate of the hemodynamic response, its detection power, which is the ability ..
  23. ncbi Work limitations among working persons with rheumatoid arthritis: results, reliability, and validity of the work limitations questionnaire in 836 patients
    Nancy Walker
    Rheumatology Division, Department of Medicine, University of Massachusetts, Worcester, Massachusett, USA
    J Rheumatol 32:1006-12. 2005
    ..To describe workplace limitations and the validity and reliability of the Work Limitations Questionnaire (WLQ) in persons with rheumatoid arthritis (RA)...
  24. doi Oxygen uptake efficiency plateau: physiology and reference values
    Xing Guo Sun
    Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, St John s Cardiovascular Research Center, 1124 West Carson Street, Torrance, CA 90509 2910, USA
    Eur J Appl Physiol 112:919-28. 2012
    The relationship of oxygen uptake [Formula: see text] to ventilation [Formula: see text], i.e., oxygen uptake efficiency (OUE) is known to differ between normal subjects and patients with congestive heart failure...
  25. doi Efficiency of hit generation and structural characterization in fragment-based ligand discovery
    Andreas Larsson
    School of Biological Sciences, Nanyang Technological University, 61 Nanyang Drive, Singapore 639798, Singapore
    Curr Opin Chem Biol 15:482-8. 2011
    ..Emerging understanding of the efficiency and operative aspects of hit generation and structural characterization in FBLD suggests that this method should ..
  26. pmc Aerobic fitness is associated with greater efficiency of the network underlying cognitive control in preadolescent children
    M W Voss
    Beckman Institute and Department of Psychology, University of Illinois, Urbana Champaign, IL 61801, USA
    Neuroscience 199:166-76. 2011
    ..coupled with different patterns of brain-behavior correlations suggest an important role of aerobic fitness in modulating task strategy and the efficiency of neural networks that implement cognitive control in preadolescent children.
  27. doi The need for standardization: a literature review of indirect costs of rheumatoid arthritis and osteoarthritis
    Feng Xie
    St Joseph s Health Care Hamilton and McMaster University, Hamilton, Ontario, Canada
    Arthritis Rheum 59:1027-33. 2008
  28. doi Effects of a trail running competition on muscular performance and efficiency in well-trained young and master athletes
    Christopher Schmidt Easthope
    University of Nice Sophia Antipolis, Nice, France
    Eur J Appl Physiol 110:1107-16. 2010
    ..monitored included MVC, twitch- and M-wave properties, EMG (RMS) of the vastus lateralis, two locomotion efficiency calculations and muscle damage markers in the blood (CK, LDH)...
  29. ncbi Self-reported reduced productivity due to musculoskeletal symptoms: associations with workplace and individual factors among white-collar computer users
    Mats Hagberg
    National Institute for Working Life, Stockholm, Sweden
    J Occup Rehabil 12:151-62. 2002
    ....
  30. ncbi Chronic physical illness, psychiatric disorder and disability in the workplace
    C S Dewa
    Centre for Addiction and Mental Health, University of Toronto, Department of Psychiatry, Ont, Canada
    Soc Sci Med 51:41-50. 2000
    ..However, with an estimated eight percent of Ontario's workforce experiencing more than two months annually of decreased productivity, it still incurs significant social and economic costs...
  31. pmc Loss of productivity due to neck/shoulder symptoms and hand/arm symptoms: results from the PROMO-study
    Swenne G van den Heuvel
    TNO Work and Employment, P O Box 718, 2130 AS, Hoofddorp, The Netherlands
    J Occup Rehabil 17:370-82. 2007
    ....
  32. doi The effect of worksite physical activity intervention on physical capacity, health, and productivity: a 1-year randomized controlled trial
    Mogens T Pedersen
    Department of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    J Occup Environ Med 51:759-70. 2009
    ..To investigate the effect of two contrasting physical activity worksite interventions versus a reference intervention (REF) on various health outcomes...
  33. ncbi Anodic electron transfer mechanisms in microbial fuel cells and their energy efficiency
    Uwe Schröder
    Institut fur Biochemie, Ernst Moritz Arndt Universitat, Felix Hausdorff Strasse 4, Greifswald, Germany
    Phys Chem Chem Phys 9:2619-29. 2007
    ..The determination of the energy efficiency of the electron transfer reactions, based on the biological standard potentials of the involved redox species in ..
  34. ncbi Reduce in variation and improve efficiency of target volume delineation by a computer-assisted system using a deformable image registration approach
    K S Clifford Chao
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 7030, USA
    Int J Radiat Oncol Biol Phys 68:1512-21. 2007
    ....
  35. doi What does research tell us about depression, job performance, and work productivity?
    Debra Lerner
    Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, MA 02111, USA
    J Occup Environ Med 50:401-10. 2008
    ..To assess the work impact of depression...
  36. ncbi Relationship between efficiency and pedal rate in cycling: significance of internal power and muscle fiber type composition
    E A Hansen
    Department of Physical Performance, The Norwegian School of Sport Sciences, Oslo, Norway
    Scand J Med Sci Sports 17:408-14. 2007
    Cycling was performed to test the following two hypotheses: (1) muscular efficiency is unrelated to pedal rate (61, 88, and 115 r.p.m...
  37. ncbi Which presenteeism measures are more sensitive to depression and anxiety?
    Kristy Sanderson
    Menzies Research Institute, University of Tasmania, Private Bag 23 Hobart TAS 7001, Australia
    J Affect Disord 101:65-74. 2007
    ..This paper examines the sensitivity of four alternative measures of presenteeism to depression and anxiety in an Australian employed cohort...
  38. pmc Methicillin-resistant Staphylococcus aureus infection or colonization present at hospital admission: multivariable risk factor screening to increase efficiency of surveillance culturing
    Clinton C Haley
    Department of Internal Medicine, Austin Medical Education Programs, Brackenridge Hospital, 601 E 15th Street, Austin, Texas 78701, USA
    J Clin Microbiol 45:3031-8. 2007
    ..If confirmed in additional studies, multivariable questionnaire screening at admission might identify a subset of admissions for surveillance cultures that would more efficiently identify most admission MRSA...
  39. doi Lowering industry firewalls: pre-competitive informatics initiatives in drug discovery
    Michael R Barnes
    Department of Computational Biology, GlaxoSmithKline, Third Avenue, Harlow, Essex, UK
    Nat Rev Drug Discov 8:701-8. 2009
    ..In this article, we discuss the background to these changes and propose new areas of collaboration in computational biology and chemistry between the public domain and the pharmaceutical industry...
  40. pmc Efficiency of specialist rehabilitation in reducing dependency and costs of continuing care for adults with complex acquired brain injuries
    L Turner-Stokes
    Regional Rehabilitation Unit, Northwick Park Hospital, Watford Road, Harrow, Middlesex HA1 3UJ, and Department of Palliative Care, Policy and Rehabilitation, King s College London School of Medicine, UK
    J Neurol Neurosurg Psychiatry 77:634-9. 2006
    To examine functional outcomes from a rehabilitation programme and to compare two methods for evaluating cost efficiency of rehabilitation in patients with severe complex disability.
  41. doi Work functioning measurement: tools for occupational mental health research
    Karen Nieuwenhuijsen
    Coronel Institute of Occupational Health, Academic Medical Center, Universiteit van Amsterdam, Amsterdam, The Netherlands
    J Occup Environ Med 52:778-90. 2010
    ..We distinguish between productivity, work role limitations, quality of work output, and extra effort required to remain productive...
  42. doi Measuring worker productivity: frameworks and measures
    Dorcas Beaton
    Mobility Program Clinical Research Unit, St Michael s Hospital and the Institute for Work and Health, University of Toronto, Toronto, ON, Canada
    J Rheumatol 36:2100-9. 2009
    ..Progress has been made in this area, revealing an ambivalent set of results that directed us back to the need to further define and then contextualize the measurement of worker productivity...
  43. ncbi Productivity and medical costs of diabetes in a large employer population
    Scott Ramsey
    Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, USA
    Diabetes Care 25:23-9. 2002
    ..The purpose of this study was to assess the economic burden of diabetes from an employer's perspective. We analyzed the costs of diabetes, using claims data for an employed population and the prevalence of selected comorbid conditions...
  44. ncbi Masticatory efficiency in children with primary dentition
    M B Gavião
    Department of Pediatric Dentistry, Dental School of Piracicaba, State University of Campinas
    Pediatr Dent 23:499-505. 2001
    The aim of this study was to evaluate masticatory efficiency in children with normal primary occlusion and malocclusion and to correlate efficiency with body variables.
  45. ncbi Estimating efficiency a priori: a comparison of blocked and randomized designs
    Andrea Mechelli
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, London, WC1N 3BG, UK
    Neuroimage 18:798-805. 2003
    This technical note deals with a priori estimation of efficiency of functional magnetic resonance imaging (fMRI) designs...
  46. ncbi Cost of lost productive work time among US workers with depression
    Walter F Stewart
    AdvancePCS Center for Work and Health, Hunt Valley, MD, USA
    JAMA 289:3135-44. 2003
    ..Evidence consistently indicates that depression has adversely affected work productivity. Estimates of the cost impact in lost labor time in the US workforce, however, are scarce and dated...
  47. ncbi Efficiency of immediately loaded mandibular full-arch implant restorations
    Winston Chee
    Advanced Prosthodontics, University of Southern California, School of Dentistry, Los Angeles, CA 90089 0641, USA
    Clin Implant Dent Relat Res 5:52-6. 2003
    ..This approach may also minimize the number of patient visits when compared with the traditional approach of implant placement and healing over a 3- to 4-month healing period...
  48. ncbi Efficiency of different methods of extraction and purification of cytokinins
    Klara Hoyerova
    Institute of Experimental Botany, Academy of Sciences of the Czech Republic, Rozvojova 135, CZ 165 02 Praha 6, Czech Republic
    Phytochemistry 67:1151-9. 2006
    ..The former method provided preparations more suitable for HPLC/MS/MS analysis with respect to simplicity and sample purity...
  49. ncbi Consensus-based findings and recommendations for estimating the costs of health-related productivity loss from a company's perspective
    Kimi Uegaki
    EMGO Institute, VU University Medical Center, Van der Boechorststraat 7, NL 1081 BT Amsterdam, Netherlands
    Scand J Work Environ Health 33:122-30. 2007
    ....
  50. ncbi [Monitoring stroke units: management, outcome, efficiency]
    C Weimar
    Klinik fur Neurologie, Universitat Duisburg Essen, Hufelandstrasse 55, 45122, Essen, Germany
    Nervenarzt 78:957-66. 2007
    ..Although the efficiency of monitoring stroke units in Germany was not shown in a randomized study, the prognostic benefit is hardly ..
  51. pmc Inclusion of high molecular weight dextran in calcium phosphate-mediated transfection significantly improves gene transfer efficiency
    C Wu
    Department of Public Health Sciences, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA
    Cell Mol Biol (Noisy-le-grand) 53:67-74. 2007
    Calcium phosphate-based mammalian cell transfection is a widely used gene transfer technology. To facilitate the efficiency of this gene transfer method, several polysaccharide compounds were tested and evaluated for their effectiveness ..
  52. ncbi Class II treatment efficiency in maxillary premolar extraction and nonextraction protocols
    Guilherme Janson
    Department of Orthodontics, Bauru Dental School, University of Sao Paulo, Bauru, Brazil
    Am J Orthod Dentofacial Orthop 132:490-8. 2007
    In this study, we compared the efficiency of nonextraction and 2-maxillary-premolar-extraction protocols in complete Class II malocclusion treatment.
  53. ncbi [Efficiency of computer-based documentation in long-term care--preliminary project]
    Markus Lungen
    Institut für Gesundheitsökonomie und Klinische Epidemiologie der Universtät zu Köln
    Pflege Z 61:334-9. 2008
    ..The results show that reducing costs is likely. The job satisfaction of the personnel increased, more time could be spent for caring for the residents. We suggest further research to reach conclusive results...
  54. doi Relatively fast! Efficiency advantages of comparative thinking
    Thomas Mussweiler
    Department of Psychology, University of Cologne, Germany
    J Exp Psychol Gen 138:1-21. 2009
    ..Seven studies examine whether, how, and when comparative thinking increases the efficiency of judgment and choice. Studies 1-4 demonstrate that procedurally priming participants to engage in more vs...
  55. ncbi Self-reported productivity loss among workers with upper extremity disorders
    Kari Pekka Martimo
    Finnish Institute of Occupational Health, Topeliuksenkatu, Helsinki, Finland
    Scand J Work Environ Health 35:301-8. 2009
    ..Upper extremity disorders (UED) are prevalent in working populations. This study investigates the prevalence, magnitude, and associated factors of on-the-job productivity loss among workers with UED...
  56. doi Scaffold percolative efficiency: in vitro evaluation of the structural criterion for electrospun mats
    Ashkan Heidarkhan Tehrani
    Department of Textile Engineering, Isfahan University of Technology, 84156 83111 Isfahan, Iran
    J Mater Sci Mater Med 21:2989-98. 2010
    ..Virtual reconstruction of the mats introduced an authentic criterion, "Scaffold Percolative Efficiency" (SPE), with which the above descriptors were addressed collectively...
  57. doi Emergency medicine provider efficiency: the learning curve, equilibration and point of diminishing returns
    Rade B Vukmir
    Department of Emergency Medicine, University of Pittsburgh, Pennsylvania, USA
    Emerg Med J 27:916-20. 2010
    ..This study described the spectrum of emergency department (ED) physician performance correlating annual workload, experience and facility issues...
  58. pmc Severity of depression and magnitude of productivity loss
    Arne Beck
    Kaiser Permanente, Denver, Colorado, USA
    Ann Fam Med 9:305-11. 2011
    ..We assessed the relationship between depression symptom severity and productivity loss among patients initiating treatment for depression...
  59. doi Improving health and energy efficiency through community-based housing interventions
    Philippa Howden-Chapman
    He Kainga Oranga Housing and Health Research Programme, University of Otago, Wellington, New Zealand
    Int J Public Health 56:583-8. 2011
    ..Our aim is to find cost-effective ways to improve the characteristics of older homes, ill-fitted for New Zealand's climate, in order to improve the occupants' health...
  60. doi Costs, equity, efficiency and feasibility of identifying the poor in Ghana's National Health Insurance Scheme: empirical analysis of various strategies
    Genevieve Cecilia Aryeetey
    Department of Primary and Community Care, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Trop Med Int Health 17:43-51. 2012
    To analyse the costs and evaluate the equity, efficiency and feasibility of four strategies to identify poor households for premium exemptions in Ghana's National Health Insurance Scheme (NHIS): means testing (MT), proxy means testing (..
  61. doi Plasmid DNA size does affect nonviral gene delivery efficiency in stem cells
    Sofia Ribeiro
    Department of Bioengineering and Institute for Biotechnology and Bioengineering IBB, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico IST, Lisboa, Portugal
    Cell Reprogram 14:130-7. 2012
    ..Based on our data we demonstrate that plasmid size severely affects the efficiency of nuclear uptake and we propose that it can also affect the rate of heterochromatin associated gene silencing ..
  62. pmc Stochastic Frontier approach and Data Envelopment Analysis to Total Factor Productivity and efficiency measurement of Bangladeshi rice
    Md Kamrul Hossain
    Mathematics Section, School of Distance Education, Universiti Sains Malaysia, Penang, Malaysia
    PLoS ONE 7:e46081. 2012
    ..Results indicate that technical efficiency was observed as higher for Boro among the three types of rice, but the overall technical efficiency of rice ..
  63. doi Improving operating theatre efficiency: an intervention to significantly reduce changeover time
    Bishoy A B Soliman
    Urology Department, Westmead Hospital, Sydney, New South Wales, Australia
    ANZ J Surg 83:545-8. 2013
    ..This study aimed to prove that the surgical registrar through active involvement in patient changeover can significantly improve operating room efficiency and minimize delays.
  64. doi Enhanced skeletal muscle lipid oxidative efficiency in insulin-resistant vs insulin-sensitive nondiabetic, nonobese humans
    Jose E Galgani
    Department of Nutrition, Diabetes, and Metabolism, Faculty of Medicine, Pontifical Catholic University of Chile, Santiago, Chile
    J Clin Endocrinol Metab 98:E646-53. 2013
    ..However, there is no evidence indicating that muscle lipid oxidative capacity is impaired in healthy otherwise insulin-resistant individuals...
  65. ncbi The effect of high-definition imaging on surgical task efficiency in minimally invasive surgery: an experimental comparison between three-dimensional imaging and direct vision through a stereoscopic TEM rectoscope
    P van Bergen
    Department of General Surgery, Eberhard Karls University, Tuebingen, Germany
    Surg Endosc 14:71-4. 2000
    ..The aim of this experimental study was to assess the impact of high definition on surgical task efficiency in minimally invasive surgery and to determine whether it is preferable to use a 3-D system or a 2-D system with ..
  66. ncbi Bayesian decision theory in sensorimotor control
    Konrad P Kording
    Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA
    Trends Cogn Sci 10:319-26. 2006
    ..This theory defines optimal behaviour in a world characterized by uncertainty, and provides a coherent way of describing sensorimotor processes...
  67. ncbi Gait efficiency using the C-Leg
    Michael S Orendurff
    Motion Analysis Laboratory, Center of Excellence for Limb Loss Prevention and Prosthetic Engineering, Department of Veterans Affairs Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
    J Rehabil Res Dev 43:239-46. 2006
    Microprocessor-controlled prosthetic knees are claimed to improve gait efficiency in transfemoral (TF) amputees...
  68. ncbi Efficiency of a third serial sputum smear examination in the diagnosis of tuberculosis in Moldova and Uganda
    A Katamba
    Department of Epidemiology, Case Western Reserve University, Cleveland, OH 44106, USA
    Int J Tuberc Lung Dis 11:659-64. 2007
    ..Twenty-four and 30 tuberculosis (TB) microscopy laboratories in Moldova and Uganda, respectively...
  69. doi Control of bimanual rhythmic movements: trading efficiency for robustness depending on the context
    Renaud Ronsse
    Department of Electrical Engineering and Computer Science Montefiore Institute, Universite de Liege, Grande Traverse 10 B28, 4000, Liege, Belgium
    Exp Brain Res 187:193-205. 2008
    This paper investigates how the efficiency and robustness of a skilled rhythmic task compete against each other in the control of a bimanual movement...
  70. ncbi Production efficiency and telomere length of the cloned pigs following serial somatic cell nuclear transfer
    Mayuko Kurome
    Laboratory of Developmental Engineering, Department of Life Science, School of Agriculture, Meiji University
    J Reprod Dev 54:254-8. 2008
    The aim of the present study was to examine the production efficiency of cloned pigs by serial somatic cell nuclear transfer (SCNT) and to ascertain any changes in the telomere lengths of multiple generations of pigs...
  71. pmc Structural efficiency of percolated landscapes in flow networks
    M Angeles Serrano
    IFISC CSIC UIB, Instituto de Física Interdisciplinar y Sistemas Complejos, Campus Universitat Illes Balears, Palma de Mallorca, Spain
    PLoS ONE 3:e3654. 2008
    ..We define quantitatively under minimal assumptions the structural efficiency of networks to determine how robust communication between the core and the peripheral components through ..
  72. doi Efficiency of self-ligating vs conventionally ligated brackets during initial alignment
    Emily Ong
    Discipline of Orthodontics, School of Dentistry, University of Queensland, Brisbane, Queensland, Australia
    Am J Orthod Dentofacial Orthop 138:138.e1-7; discussion 138-9. 2010
    The aim of this study was to compare the efficiency of self-ligating (SL) and conventionally ligated (CL) brackets during the first 20 weeks of extraction treatment.
  73. doi The effect of a computerized prescribing and calculating system on hypo- and hyperglycemias and on prescribing time efficiency in neonatal intensive care patients
    Barbara Maat
    Department of Clinical Pharmacy, University Medical Center Utrecht, Utrecht, The Netherlands
    JPEN J Parenter Enteral Nutr 37:85-91. 2013
    ..Prescribing glucose requires complex calculations because glucose is present in parenteral and enteral nutrition and drug vehicles, making it error prone and contributing to the burden of prescribing errors...
  74. doi Hand-rim forces and gross mechanical efficiency at various frequencies of wheelchair propulsion
    J P Lenton
    Peter Harrison Center for Disabilly Sport, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom
    Int J Sports Med 34:158-64. 2013
    ..the effects of push frequency changes on force application, fraction of effective force (FEF) and gross efficiency (GE) during hand-rim propulsion...
  75. pmc Teleglaucoma: improving access and efficiency for glaucoma care
    Faazil Kassam
    Division of Ophthalmology, University of Calgary, Calgary, Alberta, Canada
    Middle East Afr J Ophthalmol 20:142-9. 2013
    ..Additionally, these technologies can improve the efficiency of healthcare systems burdened with an increasing number of patients with glaucoma, and a limited supply of ..
  76. doi Efficiency of energy recovery from waste incineration, in the light of the new Waste Framework Directive
    Mario Grosso
    DIIAR Environmental Section, Politecnico di Milano, Piazza Leonardo da Vinci 32, Milan, Italy
    Waste Manag 30:1238-43. 2010
    This paper deals with a key issue related to municipal waste incineration, which is the efficiency of energy recovery...
  77. doi Semi-automating the manual literature search for systematic reviews increases efficiency
    Andrea L Chapman
    Department for Evidence based Medicine and Clinical Epidemiology, Danube University Krems, Krems, Austria
    Health Info Libr J 27:22-7. 2010
    ....
  78. doi Productivity loss due to presenteeism among patients with arthritis: estimates from 4 instruments
    Wei Zhang
    Centre for Health Evaluation and Outcome Sciences, St Paul s Hospital and School of Population and Public Health, University of British Columbia, Vancouver, British Columbia
    J Rheumatol 37:1805-14. 2010
    ..To estimate and compare lost work hours attributable to presenteeism, defined as reduced productivity while working, in individuals with osteoarthritis (OA) or rheumatoid arthritis (RA), according to 4 instruments...
  79. ncbi Obstacle course: users' maneuverability and movement efficiency when using Otto Bock C-Leg, Otto Bock 3R60, and CaTech SNS prosthetic knee joints
    Margrit R Meier
    Department of Occupational Therapy and Prosthetics and Orthotics, Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences, Norway
    J Rehabil Res Dev 49:583-96. 2012
    The performance and movement efficiency of prosthesis users while traversing a multisectional obstacle course (OC) were evaluated using a crossover design with random allocation of three prosthetic knee joints: the SNS (CaTech; Dayton, ..
  80. ncbi Torque, power and efficiency characterization of dental air turbine handpieces
    J E Dyson
    Oral Rehabilitation, University of Hong Kong, Prince Philip Dental Hospital
    J Dent 27:573-86. 1999
    ..The present work was to continue the analysis and characterization of these handpieces by addressing the issues of torque, power generation, efficiency and the specification of figures of merit to aid comparative testing and selection.
  81. ncbi The migraine ACE model: evaluating the impact on time lost and medical resource Use
    J J Caro
    Caro Research, Boston, Mass; Caro Research, Montreal, Quebec, Canada
    Headache 40:282-91. 2000
    ..The migraine model represents a flexible tool for the economic evaluation of different migraine treatments in various populations...
  82. ncbi The in vivo and in vitro efficiency and efficacy of PGD for aneuploidy
    L Gianaroli
    SISMER, Reproductive Medicine Unit, Via Mazzini 12, 40138, Bologna, Italy
    Mol Cell Endocrinol 183:S13-8. 2001
    ..6%. The in vitro efficiency of the procedure was established by analysing all the blastomeres obtained from 311 non transferrable embryos ..
  83. ncbi Free text versus structured format: information transfer efficiency of radiology reports
    Chris L Sistrom
    Department of Radiology, University of Florida Health Center, Gainesville, FL 32610, USA
    AJR Am J Roentgenol 185:804-12. 2005
    ..We discuss the effect of radiology report format on the accuracy and speed with which reviewers can extract case-specific information...
  84. doi The association between asthma control and health care utilization, work productivity loss and health-related quality of life
    Setareh A Williams
    Health Economics and Outcomes Research, AstraZeneca LP, Wilmington, DE, USA
    J Occup Environ Med 51:780-5. 2009
    ..To determine the association between asthma control and health outcomes...
  85. pmc The effectiveness of physical activity monitoring and distance counselling in an occupational health setting--a research protocol for a randomised controlled trial (CoAct)
    Karita Reijonsaari
    BIT Research Center, Helsinki University of Technology, Espoo, Finland
    BMC Public Health 9:494. 2009
    ..This article describes the design of the study and the participant flow until and including randomization...
  86. doi Prey capture efficiency in brown capuchin monkeys (Cebus apella) is influenced by sex and corpus callosum morphology
    Kaitlyn Hellner-Burris
    Department of Psychology, Hiram College, Hiram, Ohio, USA
    Am J Primatol 72:502-8. 2010
    ..the results of an experimental investigation into whether capuchins display sex differences in prey capture efficiency, and whether these differences are associated with the morphology of regions of the corpus callosum (CC) ..
  87. pmc Does user-centred design affect the efficiency, usability and safety of CPOE order sets?
    Julie Chan
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada
    J Am Med Inform Assoc 18:276-81. 2011
    Application of user-centred design principles to Computerized provider order entry (CPOE) systems may improve task efficiency, usability or safety, but there is limited evaluative research of its impact on CPOE systems.
  88. doi Workload capacity spaces: a unified methodology for response time measures of efficiency as workload is varied
    James T Townsend
    Indiana University, Bloomington, IN, USA
    Psychon Bull Rev 18:659-81. 2011
    ..We illustrate the effectiveness of the unified spaces by presenting data from two simulated models (standard parallel, coactive) and a prototypical visual detection experiment. A conversion table for the unified spaces is provided...
  89. ncbi Effectiveness of aroma on work efficiency: lavender aroma during recesses prevents deterioration of work performance
    Reiko Sakamoto
    Yamanashi Prefectural University, 5 11 1 Iida, Kofu, Yamanashi 400 0035, Japan
    Chem Senses 30:683-91. 2005
    ..No such effect was noted for the jasmine group. Although lavender is a sedative-type aroma, use during recess periods after accumulation of fatigue seems to prevent deterioration of performance in subsequent work sessions...
  90. ncbi The indirect costs of arthritis resulting from unemployment, reduced performance, and occupational changes while at work
    Xin Li
    Department of Health Care and Epidemiology, University of British Columbia, Vancouver, British Columbia, Canada
    Med Care 44:304-10. 2006
    ..The objective of this study was to assess the cost attributable to lost productivity from arthritis and the association between the degree of loss and demographic, disease-related, occupational, and psychosocial variables for people...
  91. ncbi Depression and work impairment
    Heather Gilmour
    Health Statistics Division, Statistics Canada, Ottawa, Ontario
    Health Rep 18:9-22. 2007
    ..This article estimates the prevalence of depression among employed Canadians aged 25 to 64, and examines its association with work impairment, as measured by reduced work activity, mental health/general disability days, and work absence...
  92. pmc Impact of clinical reminder redesign on learnability, efficiency, usability, and workload for ambulatory clinic nurses
    Jason J Saleem
    Veterans Association Getting at Patient Safety GAPS Center, VAMC, Cincinnati, OH, USA
    J Am Med Inform Assoc 14:632-40. 2007
    ..We examined the impact of four design modifications to CR software on learnability, efficiency, usability, and workload for intake nursing personnel in an outpatient clinic setting...
  93. ncbi Effects of oocyte quality, semen donor and embryo co-culture system on the efficiency of blastocyst production in goats
    L Katska-Ksiazkiewicz
    Department of Biotechnology of Animal Reproduction, National Research Institute of Animal Production, 32 083, Balice, Poland
    Theriogenology 68:736-44. 2007
    ..cresyl blue (BCB) would be helpful in selecting developmentally competent oocytes, and thereby increase the efficiency of blastocyst production from ovarian oocytes of FSH-primed, adult goats...
  94. doi Assessing the impact of migraine onset on work productivity
    Stephen H Landy
    Wesley Neurology Clinic, Memphis, Tennessee, USA
    J Occup Environ Med 53:74-81. 2011
    ..Examine the impact of migraine on work productivity, and particularly the association between time of migraine onset and lost productivity as measured by absenteeism and presenteeism...
  95. ncbi Delivery efficiency of metered dose aerosols given via endotracheal tubes
    S J Crogan
    Division of Respiratory Therapy, Harborview Medical Center, University of Washington School of Medicine 98104
    Anesthesiology 70:1008-10. 1989
    The authors studied the efficiency of delivery of the inhaled bronchodilator metaproterenol when delivered via an endotracheal tube (ETT) using a metered dose inhaler (MDI)...
  96. ncbi Measuring and evaluating the effects of disease on workplace productivity
    Tracy J Mayne
    Department of Outcomes Research, Pfizer Global Pharmaceuticals, New York, New York 10017, USA
    J Occup Environ Med 46:S1-2. 2004
  97. ncbi Impact of a disability management program on employee productivity in a petrochemical company
    Christopher M Skisak
    Shell Health Services Department, Shell Oil Company, Houston, Texas 77252 2463, USA
    J Occup Environ Med 48:497-504. 2006
    ..The program was administered by full-time certified, corporate-based case managers and nine manufacturing location nurses...
  98. ncbi Spatial learning efficiency and error monitoring in normal aging: an investigation using a novel hidden maze learning test
    Robert H Pietrzak
    Department of Psychology, Clinical Division, University of Connecticut, Storrs, CT 06269 1020, USA
    Arch Clin Neuropsychol 22:235-45. 2007
    ..GMLT), a novel computerized hidden maze learning test that assesses processing speed, spatial learning efficiency, and error monitoring...
  99. ncbi Costs and quality of life in multiple sclerosis in The Netherlands
    Gisela Kobelt
    Lund University, Lund, Sweden
    Eur J Health Econ 7:S55-64. 2006
    ..24 quality-adjusted life-years (QALYs) per patient. Relapses for patients with an EDSS score below 5 are associated with a cost of around euro 2.800 and a utility loss of 0.15 during the quarter in which they occur...
  100. ncbi Economics of managing atrial fibrillation: broadening the focus to include efficiency
    D George Wyse
    J Cardiovasc Electrophysiol 18:634-5. 2007
  101. ncbi The role of effort in influencing the effect of anxiety on performance: testing the conflicting predictions of processing efficiency theory and the conscious processing hypothesis
    Mark Wilson
    Manchester Metropolitan University, UK
    Br J Psychol 98:411-28. 2007
    The aim of this study was to test the conflicting predictions of processing efficiency theory (PET) and the conscious processing hypothesis (CPH) regarding effort's role in influencing the effects of anxiety on a golf putting task...

Research Grants86

  1. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  2. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
  3. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  4. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
    ..Repairing the pathway in vocal learners, when damaged, would have profound impact for correcting neurological disorders of speech. ..
  5. The Primate Corpus Luteum: Functional Regression and Cardiovascular Impacts
    Randy L Bogan; Fiscal Year: 2012
    ..CL at the end of the luteal phase has implications for preventing early pregnancy loss, and improving the efficiency of assisted reproduction technologies...
  6. Multi-targeted Countermeasures against Acute and Delayed Effects of OP Exposure
    John A Butera; Fiscal Year: 2013
    ..A dual acting single agent designed by overlapping pharmacophores would have better ligand efficiency (e.g...
  7. Angiotensin Adrenergic Interactions in the Kidney
    Roland C Blantz; Fiscal Year: 2013
    ..due to growth stimuli using DFMO, inhibitor of ornithine decarboxylase, 5) NADPH oxidase and ROS, 6) decreased efficiency of Na reabsorption using micropuncture and microinjection techniques...
  8. Enhanced iron removal with peptide linked chelators targeted to ferritin
    Elizabeth C Theil; Fiscal Year: 2010
    ..mammalian systems of iron transport or storage such as ferritin which might increase their potency or clinical efficiency. We have discovered a series of peptides that in vitro enhance the egress of stored iron from ferritin and that ..
  9. Role of SAMe on UBC9 and sumolyation in liver cancer and alcoholic liver injury
    Maria Lauda Tomasi; Fiscal Year: 2012
    ..protein and is believed to play an important role in regulating the substrate specificity and enhancing the efficiency of sumoylation in vivo...
  10. Randal J Kaufman; Fiscal Year: 2014
    ..and/or qualitative manner? The impact of eIF2a phosphorylation and CHOP expression on mRNA translational efficiency and AUG initiation codon selection will be measured using a new technique of ribosome profiling...
  11. Gary Cecchini; Fiscal Year: 2014
    ..of these complexes and their interaction with other mitochondrial proteins which affects overall mitochondrial efficiency and potentially contributes to ROS formation...
  12. IMMUNOGENETICS OF COLLAGEN INDUCED ARTHRITIS IN MICE
    Chella David; Fiscal Year: 2009
    ..These citrullinated proteins are presented with greater efficiency by HLA-DR4 leading to an autoreactive T and B cell response and disease...
  13. REGULATION OF GENE EXPRESSION BY DIETARY FAT
    Lisa M Salati; Fiscal Year: 2012
    ..greater than 60% of genes undergo alternative splicing and many are also regulated by changes in splicing efficiency, these findings will have widespread signficance for determining the proteins expressed within cells throughout ..
  14. Petr Tvrdik; Fiscal Year: 2014
    ..two distinct cell populations, such as specific neurons and glia, without any confounding issues of dye loading efficiency, viral injections, etc., because all the required tools can be brought together by breeding...
  15. Analyzer for Monitoring Personal Environmental Exposure to Fluids and Materials
    MATTHEW CUSACK; Fiscal Year: 2010
    ..proprietary, monochromatic doubly curved crystal (DCC) X-ray optics technology that greatly increases the efficiency and sensitivity for elemental analysis...
  16. Estrogen Modulation of Auditory Processing
    Raphael Pinaud; Fiscal Year: 2012
    ..Hearing disorders and lower auditory processing efficiency also occur in women with Turner's syndrome, who are deficient in E2...
  17. Role of Retroelements in Environmental Atherogenesis
    Kenneth S Ramos; Fiscal Year: 2010
    ..that L1 activation is mediated via epigenetic mechanisms that increase promoter activity and RNA polymerase II efficiency. These studies are the first to systematically examine the role of L1 and retrotransposition in diseases of the ..
  18. Improving Epigenetic-based Cell Reprogramming with Proteasome Inhibition
    Jaroslaw Staszkiewicz; Fiscal Year: 2011
    ..methods, a critical pathway that appears to be a key (if not the key) d rate limiting step to improving the efficiency of reprogramming was identified...
  19. Role of Potent Trophic Factors on Glia and Motor Neurons in ALS
    Brian K Kaspar; Fiscal Year: 2013
    ..In this proposal, we will investigate the relative efficiency of IGF-1, VEGF and GDNF to suppress aberrant glial activity and delay motor neuron death...
  20. Transforming PCI Informed Consent into an Evidence-based Decision-making Tool
    John A Spertus; Fiscal Year: 2010
    ..If Specific Aims 2-5 demonstrate that the PRISMgenerated consent forms elevate the quality, efficiency and cost-effectiveness of PCI, there will be a need to disseminate this approach - ideally through the American ..
  21. Maternal nutrient restriction and nonhuman primate fetal skeletal muscle developm
    Min Du; Fiscal Year: 2010
    ..g. maternal malnutrition, reduced placenta efficiency, adolescence pregnancy, and closely spaced pregnancy...
  22. A Clinical Trial of Aspirin and Simvastatin in Pulmonary Arterial Hypertension
    Steven Kawut; Fiscal Year: 2009
    ..We have designed a Phase II trial to initiate the study of these two potentially useful therapies with maximum efficiency and minimum expense...
  23. Intranasal CNS delivery of drugs against organophosphorous threat agents
    ARYAN MANGALAM NAMBOODIRI; Fiscal Year: 2013
    ..b>Efficiency of nose-to- brain delivery can be significantly improved by either making formulations such as mucoadhesive ..
  24. Regulation of insulins by the Rhox5 homeobox gene supports spermatogenesis
    James Maclean; Fiscal Year: 2009
    ..Mice which lack the Rhox5 gene exhibit abnormalities in sperm number, sperm motility, and breeding efficiency. Thus, the characterization of Rhox5-null mice may also be useful as a model system for understanding human ..
  25. Multivariate CART for survival with dental applications
    Martha E Nunn; Fiscal Year: 2013
    ..We also plan to refine computer algorithms we developed for multivariate CART for survival to increase computing efficiency and further extend Bayesian survival trees and random forests to correlated outcomes in order to utilize the ..
  26. Role of formyl peptide receptor variants in mucosal innate immune defense
    HEINI MARITA MIETTINEN; Fiscal Year: 2010
    ..We will measure the translational efficiency of different FPR haplotypes in a fusion construct with firefly luciferase...
  27. Jianhua Shao; Fiscal Year: 2016
    ..Furthermore, mouse embryonic fibroblasts (MEFs) from obese dams exhibited remarkable high efficiency in adipocyte differentiation, while protein levels of transcription factor C/EBP2 was significantly elevated...
  28. Natarajan Muthusamy; Fiscal Year: 2015
    ..Even then, the efficiency of ODNs for target downregulation remains overall low...
  29. ALBERT GIROTTI; Fiscal Year: 2015
    ..cell death, and much has been learned about how this is affected by factors such as sensitizer localization and efficiency of toxic oxidant generation...
  30. Exploratory Studies on the Anti-Breast Cancer Function of Bamboo Extract
    Jun Panee; Fiscal Year: 2010
    ..the long-term goal of characterizing the potentially novel anti-breast cancer compound(s) in BEX, improving the efficiency of the product, and eventually applying this abundant, easily available and sustainable natural resource in the ..
  31. Michael J Smerdon; Fiscal Year: 2014
    ..cerevisiae. We will examine the efficiency of NER of CPDs in histone mutants (sin and Irs) that require less chromatin remodeling during gene activation ..
  32. Enhance Production of Functional Recombinant Human Protein C Variant In Mammalian
    Nienwen Chow; Fiscal Year: 2010
    ..One approach is to coexpress vitamin K 2,3-epoxide reductase subunit 1 (VKORC1) to increase the efficiency of vitamin K recycling hence the enhancement of 3-carboxylation of 5A-PC...
  33. David R Jacobs; Fiscal Year: 2014
    ..to Coronary Artery Risk Development in Young Adults (CARDIA), thus utilizing its infrastructure for cost efficiency and minimal participant burden...
  34. Veena Taneja; Fiscal Year: 2014
    ..These citrullinated proteins are presented with greater efficiency by HLA-DR4 molecules leading to an autoreactive T and B cell response and disease...
  35. RNA interference therapy for Huntington's disease: studies in non-human primates
    Beverly L Davidson; Fiscal Year: 2010
    ..In this work we will test the safety and efficiency of gene therapies designed to treat the fatal neurogenetic disorder, Huntington's disease, in a clinical ..
  36. EPIDEMIOLOGY: OXIDATIVE STRESS AND EARLY ATHEROSCLEROSIS
    David Jacobs; Fiscal Year: 2009
    ..to Coronary Artery Risk Development in Young Adults (CARDIA), thus utilizing its infrastructure for cost efficiency and minimal participant burden...
  37. Human in Mouse Modeling of HNSCC to Predict Resonse to Therapy
    Wendell G Yarbrough; Fiscal Year: 2010
    ..proposed studies is to continue development of this in vivo cancer model that holds the promise to increase the efficiency and decrease the cost of drug development for HNSCC...
  38. William M Nauseef; Fiscal Year: 2014
    ..tularensis are incompletely understood. We reason that the remarkable efficiency of aerosolized F...
  39. Non-viral gene therapy for sickle cell anemia
    CLIFFORD JOHN STEER; Fiscal Year: 2012
    ..phase, Specific Aim 1 is designed to optimize the Sleeping Beauty transposon (SB-Tn) and transfection efficiency in mouse bone marrow (BM) and hematopoietic stem cells (HSCs)...
  40. FUNCTIONAL AND TARGETING POLYMERIC GENE CARRIERS
    Sung Wan Kim; Fiscal Year: 2012
    ..poly(cystamine bisacrylamide-diaminohexane), poly(CBA-DAH) will transfect primary myoblasts with superior efficiency and minimal toxicity compared to other non-viral polymeric carriers...
  41. Evaluation of novel FoxM1 inhibitors against liver cancer
    Andrei L Gartel; Fiscal Year: 2012
    ..All conventional treatments for liver cancer are fraught with side effects and limited efficiency. Hence, it is important to identify novel drugs that target the underlying molecular events of HCC growth and ..
  42. Bibo Li; Fiscal Year: 2016
    ..loci in a strictly monoallelic manner, which ensures effectiveness of VSG switching and maximizes its efficiency. Therefore, VSG switching and monoallelic VSG expression are essential for T. brucei pathogenesis...
  43. Clinton C MacDonald; Fiscal Year: 2015
    ..spermatogenesis, for example altering the protein forms of transcription factors or altering translational efficiency. DCstF-64 (gene name: Cstf2t) is the testis-expressed variant of CstF-64, an RNA-binding protein that regulates ..
  44. Marlowe Eldridge; Fiscal Year: 2016
    ..grant we am to determine the impact of BPD on 1) the pulmonary vasculature, 2) right heart function, and 3) the efficiency with which the right heart and pulmonary vasculature interact...
  45. Recombinant hepatic argininosuccinate synthase (rASS) for treatment of sepsis/end
    Stanislav I Svetlov; Fiscal Year: 2012
    ..phase I, a therapeutic grade, tag-and endotoxin-free engineered human recombinant ASS will be produced and its efficiency to treat endotoxemia/sepsis in mouse models will be established...
  46. A Novel Model of, and Pre-clinical Therapy for, Scleroderma Lung Disease
    Sergei P Atamas; Fiscal Year: 2012
    ..The mechanisms of scleroderma lung disease (SLD) are not well understood, and the efficiency of available therapies is limited...
  47. Characterizing gene regulation with single molecule sensitive probes
    Philip J Santangelo; Fiscal Year: 2013
    ..sequences, RNA binding proteins, or in upstream signaling pathways affect the stability and/or translational efficiency of mRNAs encoding proto-oncogenes, cytokines, cell cycle regulators and other regulatory proteins to promote ..
  48. Creation of hyperactive transposons for mutagenesis in rodents
    Eric M Ostertag; Fiscal Year: 2011
    ..different families of transposons, Sleeping Beauty (SB), piggyBac (PB), and TcBuster (TcB), to increase the efficiency of transposition in the germ line...
  49. Serotonin, Autism, and investigating cell types for CNS disorders.
    Joseph D Dougherty; Fiscal Year: 2010
    ..faculty in a variety of disciplines, the scientific facilities of a major institution, yet it maintains the efficiency and ease of collaboration found on a small campus. The laboratory of Dr...
  50. MENG MENG ROWLAND; Fiscal Year: 2014
    ..the fundamental tracking parameters with these variants, which will directly test how the residence time on nonspecific DNA, and the 1D diffusion constant for sliding affect the efficiency of damage repair both in vitro and in vivo.
  51. Role of Coxiella burnetii group I introns in growth modulation
    Michael F Minnick; Fiscal Year: 2010
    ..of the ribosome, an alternative strategy is to produce fewer, functional 23S rRNAs by decreased splicing efficiency in stationary phase, and this possibility will be examined...
  52. HYPOXIA AND CONTROL OF FETAL BREATHING MOVEMENTS
    Brian J Koos; Fiscal Year: 2010
    ..3) To determine the ontogeny of the distribution and coupling efficiency of brain ADO A2A receptors...
  53. Role of Mitochondria Targeted CYP2E1 and HO-1 in Alcohol Mediated Tissue Injury
    Narayan G Avadhani; Fiscal Year: 2012
    ..variations in mt-CYP2E1 levels which is likely to be associated with mutations that affect targeting efficiency of the protein...
  54. ERNESTO ROQUE BONGARZONE; Fiscal Year: 2016
    ..In addition to the loss of myelin, neurodegeneration is likely a limiting factor in reducing the efficiency of traditional therapies...
  55. Growth Factor and Antiapoptotic Gene Delivery to Human Islets
    Ram I Mahato; Fiscal Year: 2012
    ..The broad significance of this research is the potential to achieve dramatic improvement in the treatment efficiency of type 1 diabetes by human islet transplantation...
  56. The role of human DNA polymerase eta in the mutagenic response to oxidative stres
    SCOTT DAVID MCCULLOCH; Fiscal Year: 2013
    ..TLS past several DNA lesions by Y-family members occurs with higher efficiency compared to replicative polymerases, making them the preferred choice for ensuring replication is completed, ..
  57. Gilbert Di Paolo; Fiscal Year: 2014
    ..Because of its remarkable efficiency at eliminating cellular "waste" and consuming energy sources, autophagy is increasingly viewed as a pathway that ..
  58. Ellen Merrick Schill; Fiscal Year: 2015
    ..These experiments will examine if ibuprofen could be a common and avoidable exposure during pregnancy that increases HSCR risk by reducing the efficiency of ENCC migration.
  59. Stephanie Cherqui; Fiscal Year: 2016
    ..to optimize the transduction of murine Sca1+ HSC using LV expressing reporter genes to enhance the safety and efficiency of a clinical trial as well as significantly reduce costs...
  60. Functional analysis of mDia formins in hematopoietic stem cell engraftment and mi
    Peng Ji; Fiscal Year: 2010
    ..facing two obstacles: the limited number of transplantable HSCs in a bone marrow or cord blood unit;and a low efficiency of engraftment of transplanted HSCs into recipient bone marrow niches...
  61. Remodeling of the guinea pig intrinsic cardiac plexus with chronic heart disease
    ELIZABETH MARIE SOUTHERLAND; Fiscal Year: 2013
    ..adaptations of the ICN: (1) changes in neuronal responses to neuromodulators and (2) changes in ICN network efficiency. We will also evaluate the efficacy of targeted pharmacologic therapy to mitigate adverse remodeling of the ICN...
  62. Fully Biodegradable Polymersome-encapsulated Hemoglobin as a Novel Nanoparticle-b
    PAIMAN PETER GHOROGHCHIAN; Fiscal Year: 2010
    ..These dispersions will be rigorously characterized for particle size and morphology, hemoglobin encapsulation efficiency and methamoglobin (metHb) level, We will also characterize the functional properties of PEH dispersions such as ..
  63. Zhenfeng Duan; Fiscal Year: 2014
    ..MDR is presented clinically as a consequence of many factors that include poor systemic drug delivery efficiency, short residence time, poor permeability in tumor mass and intracellular availability, as well as ..
  64. Advanced Center for Latino and MH Systems Research
    Margarita Alegria; Fiscal Year: 2009
    ..Aim 4: Apply the findings of Aim 3 to make concrete recommendations to improve the efficiency and fairness of diagnostic decisions for Latino and non-Latino white population groups...
  65. RCT of US versus CT for Patients in the ED with Suspected Renal Colic
    Rebecca Smith Bindman; Fiscal Year: 2010
    ..verge of crisis according to the Institute of Medicine, and one of the solutions identified is to increase the efficiency of patient care in the ED setting...
  66. Cytokine Induced CD26 Modulation of Adult Hematopoietic Stem Cell Trafficking
    Kent Christopherson; Fiscal Year: 2009
    ..recently demonstrated that inhibition or loss of CD26 (DPPIV/dipeptidylpeptidase IV) significantly improved HSCT efficiency. We hypothesize that granulocyte colony-stimulating factor (G-CSF) and granulocyte macrophage-colony stimulating ..
  67. Convene the leaders of the multiple networks providing telehealth services in the
    STEPHEN BIGGIO; Fiscal Year: 2011
    ..and systems architecture will result in more efficient use of resources, allowing for improved quality, safety, efficiency, and effectiveness of healthcare in the region...
  68. PEPTIDE BASED DELIVERY OF HIV IMMUNOGEN
    Lee Riley; Fiscal Year: 1999
    ..This project will serve as a proof-of-the-concept project using gp120 to study the efficiency of protein delivery, intracellular processing, and antigen presentation mediated by a 22-amino acid peptide ..
  69. Ultrasound guided site-specific gene delivery in prostate cancer
    Pier Paolo Claudio; Fiscal Year: 2010
    This proposal aims at improving the efficiency and specificity of gene delivery in prostate cancer (PC) by using an innovative system consisting of ultrasound contrast agents, viral vectors and ultrasound waves...
  70. Bright and Fast Sensor for Time Resolved X-Ray Diffraction Studies
    VIVEK V NAGARKAR; Fiscal Year: 2010
    ..However, current X-ray-to- light converters provide low light conversion efficiency, low X-ray absorption, and a tradeoff between spatial resolution and efficiency, and significantly limit the ..
  71. Mechanisms of 5'UTR splicing of human surfactant protein (SP)-A1 and SP-A2
    Guirong Wang; Fiscal Year: 2011
    ..falls within the untranslated regions (5'UTR and 3'UTR) that affects mRNA stability, translation efficiency, and mRNA localization...
  72. Sleep Therapy Headset for Improving Sleep Quality of Older Adults
    PHILIP BONELLO; Fiscal Year: 2007
    ..of an effective, comfortable light-treatment device to affect the circadian system, and improve sleep efficiency of older adults...
  73. Screening for Chemicals that Potentiate TRAIL-Induced Apoptosis of Cancer Cells
    DMITRI ROZANOV; Fiscal Year: 2007
    ..Future Plans include: (1)To identify the putative targets and to determine the efficiency and selectivity of the apoptosis activation mechanism exerted by initial hits in cell-based assays; (2) Optimize ..
  74. Rapid Generation of High Affinity Protein Sensor Elements
    HYONGSOK SOH; Fiscal Year: 2009
    ..binding of the aptamers to the molecular target, the solid support or the separation apparatus degrades the efficiency of molecular partitioning...
  75. Prevention of diabetes by pDNA encoded with IL-10
    Jagdish Singh; Fiscal Year: 2010
    ..The nanoparticles will be characterized for size, shape, charge density, plasmid loading efficiency, buffering ability, and structural integrity of plasmid DNA by dynamic light scattering, electron microscopy, ..
  76. Bright and Fast Sensor for Time Resolved X-Ray Diffraction Studies
    Vivek Nagarkar; Fiscal Year: 2007
    ..However, current X-ray-to- light converters that provide low light conversion efficiency, low X-ray absorption, and a tradeoff between spatial resolution and efficiency significantly limit the ..
  77. Novel device for improving standard CPR outcomes
    Keith Lurie; Fiscal Year: 2007
    ..Phase II application is to continue the development and evaluation of a novel device designed to increase the efficiency of manual CPR...
  78. DEPOSITION OF VOLATILE AEROSOLS IN THE RESPIRATORY TRACT
    Sidney Soderholm; Fiscal Year: 1991
    ..calculated from the product of the airborne mass concentration, minute volume, exposure duration, and deposition efficiency. Deposition efficiency is estimated from mathematical models and laboratory experiments with similar airborne ..
  79. RRSS #1 - Evaluation of Process Efficiency in the Task of Case Consolidation with
    Kevin Ward; Fiscal Year: 2009
    ..places greater emphasis on achieving the desired operational outcome with relatively less attention paid to the efficiency with which the outcome is achieved...
  80. 5-HT1A RECEPTOR/G PROTEIN COUPLING AND ADAPTATION
    Emanuel Meller; Fiscal Year: 2003
    ..function is underscored by our previous studies demonstrating regional variations in receptor/effector coupling efficiency and recent evidence that chronic treatment with anxiolytic/antidepressant drugs elicits regionally specific 5-..
  81. GENETIC HETEROGENEITY IN HUMAN DISEASE
    Aravinda Chakravarti; Fiscal Year: 1992
    ..simulations to evaluate existing statistical methods, and new ones we propose, for studying the accuracy and efficiency of multipoint linkage analysis using human family data...
  82. Engineered in vivo nuclear fusion: application to regenerative medicine
    Richard C Mulligan; Fiscal Year: 2010
    ..this grant application is that genetic technologies can provide a means of dramatically increasing the efficiency of cell fusion of transplanted cells, and that such engineered cell-cell fusion in vivo can provide a broad and ..
  83. NEW FIBEROPTIC SCREENS AND FILTRATION FOR X-RAY IMAGING
    Andrew Karellas; Fiscal Year: 1990
    ..The currently attainable x-ray quantum efficiency of the state-of-the- art rare earth intensifying screens varies from 40-70%...
  84. GENE TRANSFER TO AIRWAY EPITHELIAL CELLS
    Pi Wan Cheng; Fiscal Year: 2000
    ..Hence, CF lungs have been targeted for gene therapy. Current gene therapy vectors suffer from low transfection efficiency or induction of host immune response, which preclude them from being used for gene therapy in vivo and invite ..