impotence

Summary

Summary: The inability to perform sexual intercourse.

Top Publications

  1. ncbi Sildenafil for male erectile dysfunction: a systematic review and meta-analysis
    Howard A Fink
    Geriatric Research Education and Clinical Center, Veterans Affairs Medical Center, 1 Veterans Dr, PO Box 11G, Minneapolis, MN 55417, USA
    Arch Intern Med 162:1349-60. 2002
  2. ncbi A 4-year update on the safety of sildenafil citrate (Viagra)
    Harin Padma-Nathan
    The Male Clinic, Keck School of Medicine at the University of Southern California School of Medicine, Beverly Hills, California, USA
    Urology 60:67-90. 2002
  3. ncbi Penile bulb dose and impotence after three-dimensional conformal radiotherapy for prostate cancer on RTOG 9406: findings from a prospective, multi-institutional, phase I/II dose-escalation study
    Mack Roach
    University of California San Francisco, San Francisco, CA 94143, USA
    Int J Radiat Oncol Biol Phys 60:1351-6. 2004
  4. ncbi The efficacy and safety of oral sildenafil in Thai men with erectile dysfunction: a randomized, double-blind, placebo controlled, flexible-dose study
    Apichat Kongkanand
    Department of Surgery, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    J Med Assoc Thai 86:195-205. 2003
  5. ncbi The additive erectile recovery effect of brain-derived neurotrophic factor combined with vascular endothelial growth factor in a rat model of neurogenic impotence
    Kuo Chiang Chen
    Department of Urology, University of California San Francisco, San Francisco, CA, USA
    BJU Int 95:1077-80. 2005
  6. ncbi Do lipid-lowering drugs cause erectile dysfunction? A systematic review
    Kash Rizvi
    University of Wales College of Medicine, Wrexham Academic Unit, Wrexham, UK
    Fam Pract 19:95-8. 2002
  7. ncbi Erectile dysfunction: comparison of efficacy and side effects of the PDE-5 inhibitors sildenafil, vardenafil and tadalafil--review of the literature
    Ursula Gresser
    Praxisklinik Sauerlach, Internal Medicine, Tegernseer Landstr 8, D 82054 Sauerlach, Germany
    Eur J Med Res 7:435-46. 2002
  8. ncbi Effects of tadalafil on erectile dysfunction in men with diabetes
    INIGO SAENZ DE TEJADA
    Fundacion para la Investigacion y el Desarrollo en Andrologia, Madrid, Spain
    Diabetes Care 25:2159-64. 2002
  9. ncbi Prevalence of cardiovascular risk factors in erectile dysfunction
    Monika K Walczak
    Center for Sexual Function and Section of Endocrinology, Lahey Clinic Northshore, Peabody, MA, USA
    J Gend Specif Med 5:19-24. 2002
  10. ncbi Epidemiology of erectile dysfunction in four countries: cross-national study of the prevalence and correlates of erectile dysfunction
    Alfredo Nicolosi
    Department of Epidemiology, Institute of Biomedical Technologies, National Research Council, Milan, Italy
    Urology 61:201-6. 2003

Research Grants

Detail Information

Publications272 found, 100 shown here

  1. ncbi Sildenafil for male erectile dysfunction: a systematic review and meta-analysis
    Howard A Fink
    Geriatric Research Education and Clinical Center, Veterans Affairs Medical Center, 1 Veterans Dr, PO Box 11G, Minneapolis, MN 55417, USA
    Arch Intern Med 162:1349-60. 2002
    ..To determine the efficacy and safety of sildenafil citrate in the treatment of male erectile dysfunction...
  2. ncbi A 4-year update on the safety of sildenafil citrate (Viagra)
    Harin Padma-Nathan
    The Male Clinic, Keck School of Medicine at the University of Southern California School of Medicine, Beverly Hills, California, USA
    Urology 60:67-90. 2002
    ..Lastly, we review the specific effects on the visual system based on findings from studies conducted during drug development and post marketing...
  3. ncbi Penile bulb dose and impotence after three-dimensional conformal radiotherapy for prostate cancer on RTOG 9406: findings from a prospective, multi-institutional, phase I/II dose-escalation study
    Mack Roach
    University of California San Francisco, San Francisco, CA 94143, USA
    Int J Radiat Oncol Biol Phys 60:1351-6. 2004
    To assess the relationship between the dose to the bulb of the penis and the risk of impotence in men treated on Radiation Therapy Oncology Group (RTOG) 9406.
  4. ncbi The efficacy and safety of oral sildenafil in Thai men with erectile dysfunction: a randomized, double-blind, placebo controlled, flexible-dose study
    Apichat Kongkanand
    Department of Surgery, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    J Med Assoc Thai 86:195-205. 2003
    ..To evaluate the efficacy and safety of sildenafil citrate (Viagra) in a randomized, double-blind, placebo-controlled, flexible-dose study in Thai men with erectile dysfunction of broad-spectrum etiology and more than 6 months' duration...
  5. ncbi The additive erectile recovery effect of brain-derived neurotrophic factor combined with vascular endothelial growth factor in a rat model of neurogenic impotence
    Kuo Chiang Chen
    Department of Urology, University of California San Francisco, San Francisco, CA, USA
    BJU Int 95:1077-80. 2005
    ....
  6. ncbi Do lipid-lowering drugs cause erectile dysfunction? A systematic review
    Kash Rizvi
    University of Wales College of Medicine, Wrexham Academic Unit, Wrexham, UK
    Fam Pract 19:95-8. 2002
    ..Along with the better known causes of ED, drug-induced impotence needs to be considered as a cause of this symptom. Lipid-lowering drugs have been prescribed increasingly...
  7. ncbi Erectile dysfunction: comparison of efficacy and side effects of the PDE-5 inhibitors sildenafil, vardenafil and tadalafil--review of the literature
    Ursula Gresser
    Praxisklinik Sauerlach, Internal Medicine, Tegernseer Landstr 8, D 82054 Sauerlach, Germany
    Eur J Med Res 7:435-46. 2002
    ..This adventage in terms of knowledge and safety data makes sildenafil a safe and reliable treatment for patients with erectile dysfunction...
  8. ncbi Effects of tadalafil on erectile dysfunction in men with diabetes
    INIGO SAENZ DE TEJADA
    Fundacion para la Investigacion y el Desarrollo en Andrologia, Madrid, Spain
    Diabetes Care 25:2159-64. 2002
    ..To evaluate the efficacy and safety of tadalafil taken as needed before sexual activity by men with diabetes and erectile dysfunction (ED)...
  9. ncbi Prevalence of cardiovascular risk factors in erectile dysfunction
    Monika K Walczak
    Center for Sexual Function and Section of Endocrinology, Lahey Clinic Northshore, Peabody, MA, USA
    J Gend Specif Med 5:19-24. 2002
    ..Therefore, we attempted to determine the prevalence of obesity and hyperlipidemia, along with other established risk factors such as diabetes, hypertension, and tobacco use, in men with erectile dysfunction...
  10. ncbi Epidemiology of erectile dysfunction in four countries: cross-national study of the prevalence and correlates of erectile dysfunction
    Alfredo Nicolosi
    Department of Epidemiology, Institute of Biomedical Technologies, National Research Council, Milan, Italy
    Urology 61:201-6. 2003
    ..To measure the prevalence of erectile dysfunction (ED) in community-based populations in Brazil, Italy, Japan, and Malaysia and to study its association with the demographic characteristics, medical conditions, and health-related behavior...
  11. ncbi Efficacy and safety of oral sildenafil citrate (Viagra) in the treatment of male erectile dysfunction in Colombia, Ecuador, and Venezuela: a double-blind, multicenter, placebo-controlled study
    F Gomez
    Fundacion Santafe de Bogota, Bogota, Colombia
    Int J Impot Res 14:S42-7. 2002
    ..05). Adverse events were reported for 51% and 33% of sildenafil and placebo patients, respectively. It can be concluded that sildenafil is an effective, well-tolerated treatment for ED in patients from Latin America...
  12. ncbi Efficacy and safety of tadalafil for the treatment of erectile dysfunction: results of integrated analyses
    Gerald B Brock
    Department of Surgery, Division of Urology, Faculty of Medicine and Dentistry, University of Western Ontario, London, Canada
    J Urol 168:1332-6. 2002
    ..We conducted integrated analyses of the efficacy and safety of tadalafil, a potent, selective phosphodiesterase 5 inhibitor, for the treatment of erectile dysfunction...
  13. ncbi Efficacy of oral sildenafil in hemodialysis patients with erectile dysfunction
    Ivan Seibel
    Programa de Pós Graduação em Clínica Médica e Ciências da Saúde, Faculdade de Medicina, Hospital São Lucas e Instituto de Pesquisas Biomédicas da Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil
    J Am Soc Nephrol 13:2770-5. 2002
    ..Dyspepsia was reported by two patients in the sildenafil group. In conclusion, oral sildenafil seems to be an effective and safe treatment for ED in selected patients with chronic renal failure on hemodialysis...
  14. ncbi Prevalence and risk factors for erectile dysfunction in men with diabetes, hypertension, or both diseases: a community survey among 1,412 Israeli men
    Arie Roth
    Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Clin Cardiol 26:25-30. 2003
    ..Erectile dysfunction (ED) and cardiovascular disease share common risk factors and may be further aggravated by medical treatment for reducing them...
  15. ncbi Sildenafil citrate for treatment of erectile dysfunction in men with type 1 diabetes: results of a randomized controlled trial
    Bronwyn G A Stuckey
    Keogh Institute for Medical Research, Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Australia
    Diabetes Care 26:279-84. 2003
    ..This is the first study focusing exclusively on the effects of sildenafil in men with type 1 diabetes and ED...
  16. ncbi Vardenafil, a new phosphodiesterase type 5 inhibitor, in the treatment of erectile dysfunction in men with diabetes: a multicenter double-blind placebo-controlled fixed-dose study
    Irwin Goldstein
    Boston University Medical Center, Boston, Massachusetts 02118, USA
    Diabetes Care 26:777-83. 2003
    ..This study evaluated the efficacy and safety of vardenafil treatment for erectile dysfunction (ED) in men with diabetes...
  17. ncbi A double-blind, randomised- placebo, controlled, parallel group, multicentre, flexible-dose escalation study to assess the efficacy and safety of sildenafil administered as required to male outpatients with erectile dysfunction in Korea
    H K Choi
    Department of Urology, Yonsei University Hospital, Korea
    Int J Impot Res 15:80-6. 2003
    ..8, 22.7 and 6.1% of patients, respectively), and most were mild in nature. The efficacy and safety of sildenafil in this population of Korean men appears similar to that reported in other studies in western populations...
  18. ncbi Efficacy of tadalafil for the treatment of erectile dysfunction at 24 and 36 hours after dosing: a randomized controlled trial
    Hartmut Porst
    Private Urological Practice, Hamburg, Germany
    Urology 62:121-5; discussion 125-6. 2003
    ..To examine the therapeutic effects of tadalafil on erectile dysfunction (ED) at 24 and 36 hours after dosing...
  19. ncbi Erectile dysfunction is associated with a high prevalence of hyperlipidemia and coronary heart disease risk
    Th Roumeguere
    Department of Urology, Erasme Hospital, University Clinics of Brussels, 808 Route de Lennik, B 1070, Brussels, Belgium
    Eur Urol 44:355-9. 2003
    ..The role of serum lipid levels has been demonstrated in coronary heart disease (CHD), but the relationship with ED is poorly documented. We evaluated undiagnosed hyperlipidemia in ED patients and their coronary heart disease risk...
  20. ncbi Minimal time to successful intercourse after sildenafil citrate: results of a randomized, double-blind, placebo-controlled trial
    H Padma-Nathan
    Department of Urology, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Urology 62:400-3. 2003
    ..To determine the minimal time to successful intercourse after taking sildenafil citrate for erectile dysfunction (ED)...
  21. ncbi Safety and efficacy of vardenafil for the treatment of men with erectile dysfunction after radical retropubic prostatectomy
    Gerald Brock
    St Joseph s Medical Center, Lawson Research Institute, London, Ontario, Canada
    J Urol 170:1278-83. 2003
    ..The efficacy and safety of vardenafil, a potent, selective, phosphodiesterase 5 inhibitor, was assessed for the treatment of ED after radical prostatectomy...
  22. ncbi Time course of the interaction between tadalafil and nitrates
    Robert A Kloner
    The Heart Institute, Good Samaritan Hospital, Cardiovascular Division, Keck School of Medicine, University of Southern California, Los Angeles, California 90017, USA
    J Am Coll Cardiol 42:1855-60. 2003
    ..This study was designed to determine the time course of nitrate interaction with tadalafil, a phosphodiesterase 5 (PDE5) inhibitor with a half-life (t(1/2)) of 17.5 h...
  23. ncbi A multicenter, randomized, double-blind, crossover study of patient preference for tadalafil 20 mg or sildenafil citrate 50 mg during initiation of treatment for erectile dysfunction
    Fred Govier
    Department of Urology, Virginia Mason Medical Center, Seattle, Washington 98111, USA
    Clin Ther 25:2709-23. 2003
    ..It has been shown to improve erectile function compared with placebo in Phase III studies, but clinical experience comparing tadalafil with the PDE5 inhibitor sildenafil citrate is lacking...
  24. ncbi Switching patients with erectile dysfunction from sildenafil citrate to tadalafil: results of a European multicenter, open-label study of patient preference
    Peter Ströberg
    Department of Urology, Skövde Hospital and ED Clinic, Skovde, Sweden
    Clin Ther 25:2724-37. 2003
    ..Therefore, clinical research is needed to investigate whether individual properties of the PDE5 inhibitors play a role in shaping patient preference...
  25. ncbi Effect of the angiotensin II antagonist valsartan on sexual function in hypertensive men
    R Dusing
    Medizinische Universitäts Poliklinik Bonn, Germany
    Blood Press Suppl 2:29-34. 2003
    ..Valsartan markedly increased these numbers to 6.82 +/- 1.72 and 7.06 +/- 1.68 (p < 0.0001), respectively. The results of our open study suggest that the ARB valsartan improves sexual function in hypertensive males...
  26. ncbi Should erectile dysfunction be considered as a marker for acute myocardial infarction? Results from a retrospective cohort study
    W A Blumentals
    Worldwide Epidemiology, GlaxoSmithKline Pharmaceuticals, Collegeville, Pennsylvania, USA
    Int J Impot Res 16:350-3. 2004
    ..04, 95% CI=1.39, 11.7). The risk becomes more pronounced with increasing age, indicating the need for cardiologists and internists to monitor ED patients who may not necessarily present with cardiovascular symptoms...
  27. ncbi The efficacy and safety of flexible-dose vardenafil (levitra) in a broad population of European men
    Dimitrios Hatzichristou
    Department of Urology and Center for Sexual and Reproductive Health, Aristotle University of Thessaloniki, 77 Mitropoleos str, 546 22 Thessaloniki, Greece
    Eur Urol 45:634-41; discussion 641. 2004
    ..In fixed-dose studies, vardenafil 5, 10, and 20mg improves erectile function in men with erectile dysfunction (ED). Here, the efficacy and tolerability of vardenafil when used in a flexible-dose regimen was assessed...
  28. ncbi The prevalence of hypertension, hyperlipidemia, diabetes mellitus and depression in men with erectile dysfunction
    Allen D Seftel
    School of Medicine, Case Western Reserve University and University Hospitals of Cleveland, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA
    J Urol 171:2341-5. 2004
    ..We quantified the prevalence of diagnosed hypertension, hyperlipidemia, diabetes mellitus and depression in male health plan members with erectile dysfunction (ED)...
  29. ncbi The efficacy and safety of tadalafil: an update
    C C Carson
    Department of Surgery, Division of Urology, University of North Carolina, Chapel Hill, NC, USA
    BJU Int 93:1276-81. 2004
    ..To provide an update on the efficacy and safety of tadalafil, a phosphodiesterase-5 inhibitor, in the treatment of erectile dysfunction (ED)...
  30. ncbi Efficacy of sildenafil citrate (Viagra) for the treatment of erectile dysfunction in men in remission from depression
    Jean Tignol
    Université Victor Segalen et Centre Hospitalier Charles Perrens, Bordeaux, France Dipartimento di Salute Mentale, Universita degli Studi di Torino, Orbassano, Torino, Torino, Italy
    Int Clin Psychopharmacol 19:191-9. 2004
    ..Sildenafil is an effective and well-tolerated treatment for ED in patients with a history of ED at the time of MDD diagnosis, and which persisted after the MDD was treated to remission...
  31. ncbi Oral sildenafil in the treatment of erectile dysfunction in diabetic men: a randomized double-blind and placebo-controlled study
    Mohammad R Safarinejad
    Department of Urology, Military University of Medical Sciences, P O Box 19395 1849, Tehran, Iran
    J Diabetes Complications 18:205-10. 2004
    ..To determine the efficacy and safety of oral sildenafil citrate in the treatment of erectile dysfunction (ED) in diabetic men...
  32. ncbi Relationship between erectile dysfunction and silent myocardial ischemia in apparently uncomplicated type 2 diabetic patients
    Carmine Gazzaruso
    Internal Medicine Unit, IRCCS Maugeri Foundation Hospital, Department of Internal Medicine and Medical Therapeutics, University of Pavia, Pavia, Italy
    Circulation 110:22-6. 2004
    ..In diabetic patients, CAD is often silent. Among diabetic patients with silent CAD, the prevalence of ED has never been evaluated. We investigated whether ED is associated with asymptomatic CAD in type 2 diabetic patients...
  33. ncbi The efficacy and safety of tadalafil in United States and Puerto Rican men with erectile dysfunction
    Allen D Seftel
    University Hospitals, Case Western Reserve University, Cleveland VA Medical Center, Cleveland, Ohio 44106 5046, USA
    J Urol 172:652-7. 2004
    ..We evaluate the efficacy and safety of tadalafil, taken as needed, in men with mild to severe erectile dysfunction (ED) and assess sexual intercourse attempt patterns...
  34. ncbi Time/duration effectiveness of sildenafil versus tadalafil in the treatment of erectile dysfunction in male spinal cord-injured patients
    G Del Popolo
    1Neurourology Section, Spinal Unit, Careggi Hospital, Florence, Italy
    Spinal Cord 42:643-8. 2004
    ..A randomized, blinded, crossover clinical trial comparing sildenafil versus tadalafil for erectile dysfunction (ED) in male spinal cord-injured (SCI) patients...
  35. ncbi Efficacy and treatment satisfaction with on-demand tadalafil (Cialis) in men with erectile dysfunction
    René Skoumal
    Urocentrum Brno, Czech Republic
    Eur Urol 46:362-9; discussion 369. 2004
    ..The purpose of this multicentre, randomized, double-blind, parallel group, placebo-controlled study was to evaluate efficacy and treatment satisfaction of on-demand Cialis in men with mild-to-severe erectile dysfunction (ED)...
  36. ncbi Tadalafil in the treatment of erectile dysfunction following bilateral nerve sparing radical retropubic prostatectomy: a randomized, double-blind, placebo controlled trial
    Francesco Montorsi
    Department of Urology, Universita Vita Salute San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    J Urol 172:1036-41. 2004
    ..We evaluated the efficacy and safety of tadalafil 20 mg, taken on demand, in men with erectile dysfunction following bilateral nerve sparing radical retropubic prostatectomy (BNSRRP)...
  37. ncbi Population dose-response model for tadalafil in the treatment of male erectile dysfunction
    Alexander Staab
    Global Pharmacokinetics Pharmacodynamics and Trial Simulation, Lilly Research Center, Windlesham, Surrey, United Kingdom
    Pharm Res 21:1463-70. 2004
    ..To determine the population dose-response relationship for tadalafil during on-demand (as-needed) administration for treatment of erectile dysfunction (ED)...
  38. ncbi Different effect of losartan and amlodipine on penile structures in male spontaneously hypertensive rats
    Jorge Eduardo Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, Buenos Aires, Argentina
    Am J Nephrol 24:614-23. 2004
    ....
  39. ncbi Restoration of erectile capacity in normotensive aged rats by modulation of angiotensin receptor type 1
    Kwanjin Park
    Department of Urology, Seoul National University College of Medicine, 28 Yon Gon Dong, Chongno Gu, Seoul, Korea, 110 744
    J Androl 26:123-8. 2005
    ..The results obtained indicated that alteration of the renin-angiotensin system might be implicated in the erectile dysfunction of elderly males, and modulation of this system may be of great therapeutic value...
  40. ncbi The efficacy of sildenafil for the treatment of erectile dysfunction in male peritoneal dialysis patients
    Althea Mahon
    Department of Renal Medicine, King s College Hospital, London, UK
    Am J Kidney Dis 45:381-7. 2005
    ..The aim of this study was to evaluate the safety and effectiveness of sildenafil in male peritoneal dialysis patients with erectile dysfunction...
  41. ncbi Constructions of masculinity following prostatectomy-induced impotence
    John Oliffe
    University of British Columbia, School of Nursing, T 289 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 2B5
    Soc Sci Med 60:2249-59. 2005
    ..exceeding mortality, and men are living longer with prostate cancer and the common treatment[s] side effect of impotence. Despite these epidemiological trends there is little research about men's experiences of impotence following ..
  42. pmc A double blind, randomised study of sildenafil citrate for erectile dysfunction in men with multiple sclerosis
    C J Fowler
    Department of Uro Neurology, The National Hospital for Neurology and Neurosurgery, Mailbox 71, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 76:700-5. 2005
    ..Identifying and effectively treating erectile dysfunction (ED) can result in an improvement of the quality of life (QoL) in men with multiple sclerosis (MS)...
  43. pmc Traditional herbal remedies used in the management of sexual impotence and erectile dysfunction in western Uganda
    Maud Kamatenesi-Mugisha
    Department of Botany, Makerere University, P O Box 7062, Kampala, Uganda
    Afr Health Sci 5:40-9. 2005
    ..Thus, some diseases such as sexual impotence and erectile dysfunction that deserve mention are regarded as petty though important in economic productivity, ..
  44. ncbi A 6-month study of the efficacy and safety of tadalafil in the treatment of erectile dysfunction: a randomised, double-blind, parallel-group, placebo-controlled study in Australian men
    C G McMahon
    Australian Centre for Sexual Health, St Leonards, Sydney, New South Wales 2011, Australia
    Int J Clin Pract 59:143-9. 2005
    ..8% of placebo-treated patients. The most common treatment-emergent adverse events--headache and dyspepsia--were generally mild or moderate. Tadalafil was effective and well tolerated in Australian men with mild to severe ED...
  45. ncbi Sexual dysfunction and cardiac risk (the Second Princeton Consensus Conference)
    John B Kostis
    University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ, USA
    Am J Cardiol 96:313-21. 2005
    ..Finally, further research on the role of PDE-5 inhibition in treating patients with other medical or cardiovascular disorders is recommended...
  46. ncbi Factors affecting the increased prevalence of erectile dysfunction in Greek hypertensive compared with normotensive subjects
    Michael Doumas
    4th Department of Internal Medicine, University of Athens, Attikon Hospital, Athens, Greece
    J Androl 27:469-77. 2006
    ..Erectile dysfunction affects patient quality of life, underlining the need for vigorous research of this condition and appropriate management...
  47. ncbi Sex and the heart
    E R Schwarz
    Division of Cardiology, Department of Internal Medicine, The University of Texas Medical Branch UTMB, Galveston, 77555, USA
    Int J Impot Res 17:S4-6. 2005
    ..After careful evaluation, most patients with stable cardiac disorders can resume sexual activity and/or can be treated for ED...
  48. ncbi Erectile dysfunction and subsequent cardiovascular disease
    Ian M Thompson
    Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    JAMA 294:2996-3002. 2005
    ..The risk factors for cardiovascular disease and erectile dysfunction are similar...
  49. ncbi Efficacy and safety of oral tadalafil in the treatment of men in Canada with erectile dysfunction: a randomized, double-blind, parallel, placebo-controlled clinical trial
    Serge Carrier
    Department of Urology, Jewish General Hospital, 3755 Côte Sainte Catherine E 210, Montreal, Quebec, Canada H3T 1E2
    J Sex Med 2:685-98. 2005
    ..Erectile dysfunction (ED) is a highly prevalent, often undertreated condition...
  50. ncbi Defining association between sleep apnea syndrome and erectile dysfunction
    Patrick E Teloken
    Department of Urology, Weill Medical College, Cornell University, New York Presbyterian Hospital, New York, New York 10021, USA
    Urology 67:1033-7. 2006
    ..Previous work has suggested that sleep disorders are associated with erectile dysfunction...
  51. pmc Sildenafil (Viagra) for male erectile dysfunction: a meta-analysis of clinical trial reports
    R A Moore
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, The Churchill, Headington, Oxford, UK
    BMC Urol 2:6. 2002
    ..Evaluation of company clinical trial reports could provide information for meta-analysis at the commercial introduction of a new technology...
  52. ncbi Randomized, double-blind, placebo-controlled trial of sildenafil (Viagra) for erectile dysfunction after rectal excision for cancer and inflammatory bowel disease
    Ian Lindsey
    Department of Colorectal Surgery, John Radcliffe Hospital, Oxford, United Kingdom
    Dis Colon Rectum 45:727-32. 2002
    ..We aimed to determine the efficacy of sildenafil after rectal excision for rectal cancer and inflammatory bowel disease...
  53. ncbi Efficacy and safety of flexible-dose oral sildenafil citrate (Viagra) in the treatment of erectile dysfunction in Brazilian and Mexican men
    S Glina
    Hospital Albert Einstein, Sao Paulo, Brazil
    Int J Impot Res 14:S27-32. 2002
    ..Sildenafil treatment was well tolerated. The most common adverse events were headache and flushing. In conclusion, sildenafil is a well-tolerated and effective treatment for ED of broad-spectrum etiology in Latin American men...
  54. ncbi Sildenafil citrate (Viagra) in the treatment of men with erectile dysfunction in southern Latin America: a double-blind, randomized, placebo-controlled, parallel-group, multicenter, flexible-dose escalation study
    E Becher
    Centro de Diagnóstico Urológico, Buenos Aires, Argentina
    Int J Impot Res 14:S33-41. 2002
    ..Headache and flushing, usually mild and transient, were the most common adverse events. Sildenafil was an effective, well-tolerated treatment for men in southern Latin America with broad-spectrum ED...
  55. ncbi Efficacy and safety of sildenafil citrate (Viagra) in black and Hispanic American men
    Jay M Young
    South Orange County Urological Medical Associates, Laguna Woods, California 92653, USA
    Urology 60:39-48. 2002
    ..These data demonstrate that despite differences in prevalence rates of comorbidities, efficacy and safety of sildenafil is maintained across different ethnic groups...
  56. ncbi The neuropathy of erectile dysfunction
    C B Bleustein
    Department of Urology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York 10467, USA
    Int J Impot Res 14:433-9. 2002
    ..The sensory threshold methods utilized represent novel, non-invasive and relatively simple procedures, which can be used in a longitudinal fashion to assess a patient's neurological response to therapies...
  57. ncbi Treatment of antidepressant-associated sexual dysfunction with sildenafil: a randomized controlled trial
    H George Nurnberg
    Department of Psychiatry, Health Sciences Center, University of New Mexico School of Medicine, 2400 Tucker NE, Albuquerque, NM 87131 5288, USA
    JAMA 289:56-64. 2003
    ..Sexual dysfunction is a common adverse effect of antidepressants that frequently results in treatment noncompliance...
  58. ncbi Cardiovascular safety of sildenafil
    Diane Tran
    Department of Clinical Pharmacology, St George Hospital, University of New South Wales, Kogarah, New South Wales, Australia
    Drug Saf 26:453-60. 2003
    ..Sildenafil appears to be generally well tolerated in most patients with chronic, stable cardiovascular disease...
  59. ncbi Efficacy and safety of sildenafil citrate (Viagra) for the treatment of erectile dysfunction in men in Egypt and South Africa
    I P Levinson
    1Medi Clinic Hospital, Pietermaritzburg, South Africa currently, GI GU Unit, Pfizer Global Research and Development, New London, Connecticut 06320, USA
    Int J Impot Res 15:S25-9. 2003
    ..These results are consistent with clinical trials in other countries. We conclude that sildenafil is an efficacious and well-tolerated treatment for men with ED in Egypt and South Africa...
  60. ncbi Quality of life, impotence, and activity level in a randomized trial of immediate repair versus surveillance of small abdominal aortic aneurysm
    Frank A Lederle
    Department of Medicine, Vetertans Affairs Medical Center III 0, Minneapolis, MN 55417, USA
    J Vasc Surg 38:745-52. 2003
    ....
  61. ncbi Efficacy and safety of sildenafil citrate in men with erectile dysfunction and stable coronary artery disease
    Robert F Debusk
    Stanford Cardiac Rehabilitation Program, Stanford University School of Medicine, Palo Alto, California 94304, USA
    Am J Cardiol 93:147-53. 2004
    ..There were no serious drug-related cardiovascular effects. Thus, sildenafil is an effective and well-tolerated treatment for ED in men with CAD. Sildenafil was not associated with additional safety risks in this patient population...
  62. ncbi Natural remedies for impotence in medieval Persia
    M Khaleghi Ghadiri
    Institut fur Physiologie, Universitat Munster, Robert Koch Strasse, Munster, Germany
    Int J Impot Res 16:80-3. 2004
    ..Many of the approaches of practitioners in medieval Persia are accurate and accepted even today; however, still more of them could be of use to modern medicine. The present review provides an overview of the knowledge of ED at the time...
  63. ncbi Evaluation of the safety of sildenafil for male erectile dysfunction: experience gained in general practice use in England in 1999
    A Boshier
    Drug Safety Research Unit, Bursledon Hall, Blundell Lane, Southampton SO31 1AA, UK
    BJU Int 93:796-801. 2004
    ....
  64. ncbi Cardiovascular parameter changes in patients with erectile dysfunction using pde-5 inhibitors: a study with sildenafil and vardenafil
    Giorgio Pomara
    Department of Urology, Pisa University, Pisa, Italy
    J Androl 25:625-9. 2004
    ..Moreover, it is necessary to pay particular attention to those patients in treatment with other drugs that could have a synergistic hypotensive effect as a result of vasodilation potentiation...
  65. ncbi Efficacy and safety of tadalafil in a Western European population of men with erectile dysfunction
    Ian Eardley
    Department of Urology, St James University Hospital, Leeds, West Yorkshire, UK
    BJU Int 94:871-7. 2004
    ....
  66. ncbi Overactive corpus cavernosum: a novel cause of erectile dysfunction
    A Shafik
    Department of Surgery and Experimental Research, Faculty of Medicine, Cairo University, Cairo, Egypt
    Andrologia 36:378-83. 2004
    ..This condition of 'overactive CC' should be considered in the diagnosis of ED. However, further studies in the pathogenesis of the condition are warranted...
  67. ncbi Electrocavernosogram in erectile dysfunction: a diagnostic tool
    A Shafik
    Department of Surgery and Experimental Research, Faculty of Medicine, Cairo University, Cairo, Egypt
    Arch Androl 50:317-25. 2004
    ..We suggest that electrocavernosography has the potential to function as an investigative tool in diagnosing the type of ED provided further studies are performed to verify the described findings...
  68. ncbi Erectile response with vardenafil in sildenafil nonresponders: a multicentre, double-blind, 12-week, flexible-dose, placebo-controlled erectile dysfunction clinical trial
    Culley C Carson
    School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7235, USA
    BJU Int 94:1301-9. 2004
    ..To evaluate the efficacy of vardenafil in patients previously unresponsive to sildenafil...
  69. ncbi Efficacy, safety, and treatment satisfaction of tadalafil versus placebo in patients with erectile dysfunction evaluated at tertiary-care academic centers
    Culley Carson
    Division of Urology, University of North Carolina, Chapel Hill, North Carolina 27599 7235, USA
    Urology 65:353-9. 2005
    ..To determine the efficacy, safety, and treatment satisfaction of tadalafil 20 mg for erectile dysfunction (ED) in patients evaluated at tertiary-care academic centers...
  70. ncbi Erectile dysfunction (ED) is prevalent, bothersome and underdiagnosed in patients consulting urologists for benign prostatic syndrome (BPS)
    C E Hoesl
    Department of Urology, Hospital Barmherzige Brüder, Technical University Munich, Romanstr 93, 80639 München, Germany
    Eur Urol 47:511-7. 2005
    ....
  71. ncbi Health issues of men: prevalence and correlates of erectile dysfunction
    R Shabsigh
    Department of Urology, Columbia University, New York, New York 10032, USA
    J Urol 174:662-7. 2005
    ..The prevalence of erectile dysfunction (ED) and its correlation with patient age, overall health and comorbidities were assessed...
  72. ncbi Evaluation of acute risk for myocardial infarction in men treated with sildenafil citrate
    Murray A Mittleman
    Cardiovascular Epidemiology Research Unit, Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 96:443-6. 2005
    ....
  73. ncbi Evaluation and medical management of erectile dysfunction
    Thomas J Beckman
    Division of General Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 81:385-90. 2006
    ..Additionally, we review major considerations when prescribing phosphodiesterase type 5 inhibitors and other medical treatments, including intraurethral alprostadil, penile injection therapy, and testosterone replacement...
  74. ncbi Hypertension, anti-hypertensive drug therapy and erectile dysfunction in diabetes
    P K Moulik
    Department of Medicine, Whiston Hospital, Prescot, UK
    Diabet Med 20:290-3. 2003
    ..The risk factors for ED were studied with particular reference to hypertension and anti-hypertensive drugs...
  75. ncbi New achievements and pharmacotherapeutic approaches to impotence in the elderly
    Gaetano Frajese
    Department of Internal Medicine, Roma Tor Vergata University, Roma, Italy
    Aging Clin Exp Res 15:222-33. 2003
    Erectile dysfunction (ED) has a negative impact on the quality of life of elderly men, but impotence is not an absolute concomitant of aging...
  76. ncbi Sustained efficacy and tolerability with vardenafil over 2 years of treatment in men with erectile dysfunction
    C Stief
    Department of Urology, Medizinische Hochschule, Hannover, Germany
    Int J Clin Pract 58:230-9. 2004
    ..Most treatment-emergent events were mild and transient with no cardiovascular safety concerns. These results support the long-term efficacy, reliability and tolerability of vardenafil 10 and 20 mg in men with ED...
  77. ncbi Safety and efficacy of vardenafil in patients with erectile dysfunction: result of a bridging study in Japan
    Koichi Nagao
    Department of Urology, Toho University School of Medicine, Ota ku, Tokyo, Japan
    Int J Urol 11:515-24. 2004
    ..The current study investigated the safety and efficacy of this new PDE5 inhibitor in Japanese men with ED...
  78. ncbi Erectile dysfunction: prevalence, etiology, and major risk factors
    Margaret R H Nusbaum
    UNC Family Medicine Program at University of North Carolina at Chapel Hill, 204 Parkside Circle, Chapel Hill, NC 27516 9170, USA
    J Am Osteopath Assoc 102:S1-6. 2002
    ..Early identification, behavior modification, and increased therapeutic options may improve patient outcomes...
  79. ncbi Vardenafil (Levitra) for erectile dysfunction: a systematic review and meta-analysis of clinical trial reports
    S Markou
    Akrata Medical Center, Greece
    Int J Impot Res 16:470-8. 2004
    ..Vardenafil, in all treatment regimens, shows to possess superior efficacy to placebo in the treatment of patients with erectile dysfunction. More data is needed on patients' subgroups...
  80. ncbi Pharmacotherapy of erectile dysfunction: focus on cardiovascular safety
    Thorsten Reffelmann
    The Heart Institute, Good Samaritan Hospital, Division of Cardiovascular Medicine, Keck School of Medicine, University of Southern California, 1225 Wilshire Boulevard, Los Angeles, CA 90017 2395, USA
    Expert Opin Drug Saf 4:531-40. 2005
    ..When a stable cardiac condition can be achieved (low risk group), oral treatment for erectile dysfunction may be appropriate...
  81. ncbi Efficacy and safety of on-demand oral tadalafil in the treatment of men with erectile dysfunction in Taiwan: a randomized, double-blind, parallel, placebo-controlled clinical study
    Kuang Kuo Chen
    Department of Surgery, Taipei Veterans General Hospital, Taiwan
    J Sex Med 1:201-8. 2004
    ..Past clinical trials have assessed its efficacy and safety in western populations. Tadalafil has not been investigated in a large clinical trial with a South-east Asian population...
  82. ncbi Phosphodiesterase type 5 as a pharmacologic target in erectile dysfunction
    Jackie D Corbin
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    Urology 60:4-11. 2002
    ..Selective inhibition of PDE5 is a rational therapeutic approach in ED, as proved by the clinical success of sildenafil...
  83. ncbi The efficacy of sildenafil citrate (Viagra) in clinical populations: an update
    Culley C Carson
    Department of Surgery, Division of Urology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7235, USA
    Urology 60:12-27. 2002
    ..Findings from published accounts of sildenafil use in the clinical practice setting further demonstrated that sildenafil is an effective treatment for a wide range of patients with ED...
  84. ncbi Achieving treatment optimization with sildenafil citrate (Viagra) in patients with erectile dysfunction
    Andrew R McCullough
    Department of Urology, New York University Medical Center, New York, New York 10016, USA
    Urology 60:28-38. 2002
    ..Using these recommended measures, most men with ED, including those whose treatment was previously unsuccessful, can be treated successfully with sildenafil...
  85. ncbi Efficacy and safety of sildenafil citrate (Viagra) in men with erectile dysfunction and spinal cord injury: a review
    Fadel Derry
    National Spinal Injuries Center, Stoke Mandeville Hospital, Buckinghamshire, United Kingdom
    Urology 60:49-57. 2002
    ..Symptoms of autonomic dysreflexia were not reported in any study. Existing evidence suggests that oral sildenafil is a highly effective and well-tolerated treatment for ED associated with SCI...
  86. ncbi Treatment of erectile dysfunction in patients with Peyronie's disease using sildenafil citrate
    L A Levine
    Department of Urology, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    Int J Impot Res 14:478-82. 2002
    ..EDITS questionnaire results reveal that SC is an agent that allowed successful coitus in 70.8% of males with PD...
  87. ncbi Acceptance, efficacy and preference of Sildenafil in patients on long term auto-intracavernosal therapy: a study with follow-up at one year
    J Buvat
    Centre ETPARP, 3 rue Carolus, 59000 Lille, France
    Int J Impot Res 14:483-6. 2002
    ..To assess the acceptance, long term efficacy and preference of Sildenafil in impotent patients previously on auto-intracavernosal therapy...
  88. ncbi Erectile function after radical prostatectomy: a review
    E J H Meuleman
    Department of Urology, University Medical Center, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Eur Urol 43:95-101; discussion 101-2. 2003
    ..We examined the current literature as to aetiology, treatment and possible prevention of ED following prostatectomy...
  89. ncbi Sildenafil response is influenced by the G protein beta 3 subunit GNB3 C825T polymorphism: a pilot study
    Herbert Sperling
    Department of Urology, University Hospital Essen, Germany
    J Urol 169:1048-51. 2003
    ..We investigated a potential association of the G protein beta 3 subunit (GNB3) C825T polymorphism, a determinant of intracellular signal transduction, with the drug response to sildenafil in patients with erectile dysfunction...
  90. ncbi Pharmacology of phosphodiesterase 5 inhibitors
    Serge Carrier
    McGill University Health Centre, CUSM Royal Victoria Hospital, 687 West Pines Avenue, Montreal, Quebec H3A 1A1, Canada
    Can J Urol 10:12-6. 2003
    ..Sildenafil, tadalafil, and vardenafil are all potent inhibitors of PDE5 and show the same mechanism of action, although they have some pharmacological differences that may translate into varying clinical effects...
  91. ncbi Vardenafil reverses erectile dysfunction induced by paroxetine in rats
    J Angulo
    Fundacion para la Investigacion y el Desarrollo en Andrologia, Dept de Investigación, Hospital Ramon y Cajal, Madrid, Spain
    Int J Impot Res 15:90-3. 2003
    Selective serotonin reuptake inhibitors (SSRIs) are associated with a high incidence of impotence. Paroxetine is an extensively used SSRI that has been shown to impair erectile function in patients, to induce erectile dysfunction and to ..
  92. ncbi PDE-5 inhibition and sexual response: pharmacological mechanisms and clinical outcomes
    Raymond C Rosen
    UMDNJ Robert Wood Johnson Medical School, Department of Psychiatry, Piscataway, NJ 08854, USA
    Annu Rev Sex Res 13:36-88. 2002
    ..The potential impact on societal attitudes toward sexuality and sexual dysfunction also warrants consideration...
  93. ncbi Long-term effect of sildenafil citrate on erectile dysfunction after radical prostatectomy: 3-year follow-up
    Rupesh Raina
    Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Urology 62:110-5. 2003
    ..To evaluate the long-term effect and safety of sildenafil citrate for the treatment of erectile dysfunction after radical prostatectomy (RP)...
  94. ncbi Recent advances in the treatment of erectile dysfunction in patients with diabetes mellitus
    Nandan Koppiker
    Pfizer Global Research and Development, Sandwich, Kent, United Kingdom
    Endocr Pract 9:52-63. 2003
    ..To present current information on the pathogenesis of and available therapeutic options for erectile dysfunction (ED) in patients with diabetes...
  95. ncbi Comparative effects of sildenafil, phentolamine, yohimbine and L-arginine on the rabbit corpus cavernosum
    F M Sharabi
    Department of Pharmacology, Faculty of Pharmacy, University of Alexandria, El Khartoom Square, Alexandria, Egypt
    Fundam Clin Pharmacol 18:187-94. 2004
    ..In addition, the combination of less effective doses of sildenafil and L-arginine has a potential advantage on erectile functions. The importance of this combination remains to be solved clinically...
  96. ncbi Mechanisms of action of PDE5 inhibition in erectile dysfunction
    J D Corbin
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennesse 37219, USA
    Int J Impot Res 16:S4-7. 2004
    ..Binding of cGMP to the allosteric site further stimulates enzymatic activity. Thus phosphorylation of PDE5 and binding of cGMP to the noncatalytic sites mediate negative feedback regulation of the cGMP pathway...
  97. ncbi Vardenafil improved patient satisfaction with erectile hardness, orgasmic function and sexual experience in men with erectile dysfunction following nerve sparing radical prostatectomy
    Ajay Nehra
    Department of Urology, Mayo Clinic, Rochester, Minnesota, USA
    J Urol 173:2067-71. 2005
    ..We report additional parameters important to patient perceptions regarding erection quality and satisfaction with sexual experience following NS-RRP...
  98. ncbi Recovery of erection after pelvic urologic surgery: our experience
    L Gallo
    Division of Urology, National Cancer Institute, Fondazione Pascale, Naples, Italy
    Int J Impot Res 17:484-93. 2005
    ..However, based on the data from the literature, there is a strong belief that such an approach will lead to an earlier recovery of EF than without rehabilitative treatment...
  99. ncbi Is laparoscopic unilateral sural nerve grafting during radical prostatectomy effective in retaining sexual potency?
    Francesco Porpiglia
    Division of Urology, Department of Clinical and Biological Sciences, University of Turin San Luigi Hospital, Turin, Italy
    BJU Int 95:1267-71. 2005
    ..To present a pilot study of laparoscopic unilateral sural nerve grafting during radical prostatectomy, with the aim of preserving sexual potency...
  100. ncbi In vivo and in vitro response of corpus cavernosum to phosphodiesterase-5 inhibition in the hypercholesterolaemic rabbit
    Farzeen Firoozi
    Division of Urology, Albany Medical College, Albany, NY 122083499, USA
    BJU Int 96:164-8. 2005
    ....
  101. ncbi Penetration and maintenance of erection with vardenafil: a time-from-dosing analysis
    Luc Valiquette
    Service d Urologie, CHUM Hopital St Luc, Montreal, Quebec, Canada
    Can J Urol 12:2687-98; discussion 2699. 2005
    ....

Research Grants64

  1. Effectivenss of a New Non-Invasive Erectile Support System in Aging Populations
    S ALEXANDER WEINSTOCK; Fiscal Year: 2012
    ..consequence of aging, most men experience some form of erectile dysfunction (ED), which, in severe cases, causes impotence (the inability to sustain an erection sufficient to engage and complete vaginal intercourse)...
  2. Underserved Men's Understanding of Androgen Deprivation Therapy Related Risks
    Sally L Maliski; Fiscal Year: 2012
    ..with underserved men in two studies;one on the meaning of prostate cancer treatment-related incontinence and impotence among low-income African American and Latino men and the second on the impact for prostate cancer treatment-..
  3. Stem cells for novel gene delivery of nitric oxide in the gut
    Hiroshi Mashimo; Fiscal Year: 2013
    ..but in a wide range pathologies prevalent in our aging Veteran population such as spinal cord injuries, male impotence, urinary incontinence in which nitric oxide play a major role, and in a wide range of neuropathies resulting ..
  4. Development of mutant selective EGFR kinase inhibitors against EGFR T790M
    John Chant; Fiscal Year: 2010
    ..This is likely due to their relative impotence against EGFR T790M (micromolar) versus their potency against wild type EGFR...
  5. Lauren M McIntyre; Fiscal Year: 2015
    ..In addition, intoxication can increase aggression, cause impotence, and decrease sexual inhibition and locomotor skills...
  6. MATHEW LAXMAN THAKUR; Fiscal Year: 2016
    ..biopsy procedures and under treatment or over treatment that yield minimal benefits, incontinence, or impotence. We will test our hypothesis in four Specific Aims: i) Evaluate two Cu-64 peptides specific for VPAC1 by imaging ..
  7. Real-time multiphoton microscopy of periprostatic tissue architecture
    Ashutosh K Tewari; Fiscal Year: 2010
    ..cancerous cells from nerves can result in the incomplete removal of the cancer and/or postoperative impotence due to the damage or excision of the nerves...
  8. In vivo feasibility of a peripheral nerve imaging agent
    Stephen B Kahl; Fiscal Year: 2013
    ..in radical or nerve-sparing prostatectomies is to minimize the neurological complications that can lead to impotence in about 10%-30% of cases and incontinence in about 10% of cases...
  9. Prostate cancer health literacy in rural versus urban African-American men.
    Kerry Laing Kilbridge; Fiscal Year: 2010
    ..It is critical for physicians and patients to be able to accurately discuss the impotence, incontinence, and bowel symptoms that often result from treatment, so patients can decide whether to be ..
  10. PREVENTION AND TREATMENT OF IMPOTENCE
    Tom F Lue; Fiscal Year: 2013
    ..Supported by NIH grant "Treatment and prevention of impotence" RO 1 DK45370, Jan 1/1998- 12/31/2001, we found that systemic growth hormone and insulin-like growth factor (IGF)..
  11. Comparative Effectiveness of Localized Prostate Cancer Treatments (Pilot Study)
    Austin B Frakt; Fiscal Year: 2013
    ..Because of the lifestyle implications of side effects (including impotence and incontinence), choice of treatment is difficult for many patients...
  12. Commercial Software for Modeling of G Protein-Coupled Receptors
    Ramy Farid; Fiscal Year: 2012
    ..GPCRs are also involved in depression, schizophrenia, sleeplessness, hypertension, impotence, anxiety, stress, renal failure, several cardiovascular disorders and inflammations...
  13. Imaging the effects of androgen deprivation therapy on cognitive functions in pat
    HERTA HUEY AN CHAO; Fiscal Year: 2010
    ..risks of ADT have been described in the past and include a range of constitutional symptoms, loss of libido and impotence. However, the impact of ADT on cognitive functions, a major determinant of quality of life, remains unclear...
  14. Examining the Gating Mechanisms of the Large-Conductance Ca2+ -activated K+ Chann
    DANIEL HENRY COX; Fiscal Year: 2010
    ..are currently being sought for the treatment of such diverse conditions as high blood pressure, stroke, asthma, impotence and incontinence...
  15. Aytekin Oto; Fiscal Year: 2014
    ..have also been associated with high risk of complications altering quality of life such as incontinence and impotence. Based on these facts, focal treatment methods which are not associated with serious complications but aim to ..
  16. MOLECULAR MECHANISMS OF CORPUS CAVERNOSUM FIBROSIS
    Robert Moreland; Fiscal Year: 1999
    ..Vasculogenic impotence secondary to veno-occlusive dysfunction from structural changes is a common cause of erectile impairment and a ..
  17. Gamma Ray Spectroscopy for Dose Rate Constants
    Ravinder Nath; Fiscal Year: 2006
    ..The treatment related morbidity such as urinary incontinence and sexual impotence is fairly low for seed implantation, and control of the cancer in selected patients is as good as that with ..
  18. TREATMENT AND PREVENTION OF IMPOTENCE
    Tom Lue; Fiscal Year: 1990
    In this renewal application, we propose to investigate further: the ultrastructure of the penile erection tissue; impotence due to arterial insufficiency and venous leakage; and the feasibility of intraoperative electrostimulation of the ..
  19. TOXICOLOGICAL ASPECTS OF HEMOPROTEIN REGULATION
    Yoichi Osawa; Fiscal Year: 2004
    ..plays a key role in penile erection and antihypertensive agents as well as cigarette smoking are known to cause impotence. Several metabolism-based in activators, including guanabenz, were found to cause the enhanced proteolytic ..
  20. HEMOCHROMATOSIS--GENETIC PREVALENCE AND PENETRANCE
    PRADYUMMA PHATAK; Fiscal Year: 2002
    ..organ dysfunction including hepatic cirrhosis, diabetes mellitus, congestive heart failure, arthropathy and impotence. Early diagnosis and institution of phlebotomy treatments will prevent disease manifestations and normalize life ..
  21. PROSTATE CANCER--FAMILY CARE FOR PATIENTS AND SPOUSES
    Laurel Northouse; Fiscal Year: 2005
    ..Treatments for prostate cancer are often accompanied by devastating complications such as sexual impotence, urinary incontinence, and bowel dysfunction that can severely affect the quality of life of men and their ..
  22. MANAGING UNCERTAINTY IN ADVANCED PROSTATE CANCER
    Merle Mishel; Fiscal Year: 2001
    ..Treatment for advanced prostate cancer has a myriad of side-effects including loss of libido, impotence, feminization, incontinence, and pain from metastases...
  23. Fetal Basis of Sexual Dysfunction: Brain Differentiation
    D N Rao Veeramachaneni; Fiscal Year: 2007
    ..exposure of rabbits to vinclozolin results in significant disruption of masculine sexual behavior and causes impotence. The preoptic/anterior hypothalamic area (POA/AH) is one of the most sexually dimorphic regions of vertebrate ..
  24. MOTOR NEURON DISEASES AND TROPHIC THERAPIES
    Donald Price; Fiscal Year: 2000
    ..motor neurons, respectively, whereas patients with multiple system atrophy (MSA) develop, among other signs, impotence and incontinence, both of which are caused by lesions of Onufrowicz's (Onuf's) nucleus...
  25. Anti-Cancer Ginsenosides: Their Interactions and Mechanisms of Action
    Laura Murphy; Fiscal Year: 2007
    ..Ginseng is an herb widely used by humans to treat lack of stamina, loss of appetite and cachexia, and impotence. In Asian medicine, ginseng is a common component in herbals used for cancer treatment...
  26. DIABETES AND ERECTILE FUNCTION
    Rajvir Dahiya; Fiscal Year: 2002
    ..The long term goal of this application is to investigate the cellular and molecular mechanisms of diabetic impotence. Based on prior publications and preliminary data, we hypothesize that diabetic impotence is associated with ..
  27. GENETIC APPROACH TO INSULIN SIGNALING
    FREDERICK STANLEY; Fiscal Year: 2001
    ..diabetes have been suggested to account for several disorders including infant respiratory distress syndrome and impotence. The long-term goal of this research is to discover all of the components of this regulation and how they ..
  28. GENE DEFECTIVE IN HEREDITARY HEMOCHROMATOSIS
    William Sly; Fiscal Year: 2002
    ..in a variety of organs causing cirrhosis, hepatocellular cancer, diabetes, heart failure, arthritis, and impotence. An MHC class I-like candidate gene, called HLA-H, has been identified...
  29. Commercial Software for Modeling of G Protein-Coupled Receptors
    Ramy Farid; Fiscal Year: 2009
    ..GPCRs are also involved in depression, schizophrenia, sleeplessness, hypertension, impotence, anxiety, stress, renal failure, several cardiovascular disorders and inflammations...
  30. PRESURGICAL STRESS REDUCTION MENTAL HEALTH AND CANCER
    Lorenzo Cohen; Fiscal Year: 2002
    ..At least 50 percent of RP patients have permanent impotence and many experience prolonged periods of urinary incontinence...
  31. HUMAN PROLACTINOMAS
    AMBER OCHOA; Fiscal Year: 1999
    ..Manifestations of hyperprolactinemia include infertility in women and impotence in men...
  32. EFFECT OF ALCOHOL ON SEXUAL FUNCTION
    ROGER LESTER; Fiscal Year: 1980
    ..Past experience establishes that up to 80 percent of hard core male alcoholics experience impotence, sterility and gonadal atrophy...
  33. PHYSIOLOGY OF PENILE SMOOTH MUSCLE
    Irwin Goldstein; Fiscal Year: 1999
    ..if sodium- potassium ATPase is involved in digoxin-associated impotence); and V) to determine if systemic diseases (i.e...
  34. REGULATION OF PDE 5 IN HUMAN PENILE SMOOTH MUSCLE CELLS
    Noel Kim; Fiscal Year: 2001
    ..The efficacy of this inhibitor in ameliorating erectile function in men with impotence, resulting from a broad range of etiologies, emphasizes the crucial aspect which PDE5 plays in regulating penile ..
  35. PREVENTION AND TREATMENT OF IMPOTENCE
    Tom Lue; Fiscal Year: 2001
    ..of growth hormone or IGF could become an important preventative and therapeutic manure for neurogenic impotence in humans...
  36. Adjuvant Ginseng Use During Breast Cancer Drug Therapy
    Laura Murphy; Fiscal Year: 2005
    Ginseng is an herb widely used by humans to treat lack of stamina, loss of appetite and cachexia, and impotence. In Asian medicine, ginseng is a common component in herbals used in treatment of cancer, including breast cancer...
  37. Mechanism of Action of Anabolic-Androgenic Steroids
    AMY CADWALLADER; Fiscal Year: 2007
    ..steroids (AAS), which activate the human androgen receptor (hAR), are used clinically to treat hypogonadism, impotence, and muscle wasting disorders...
  38. Prostate Cancer Utilities Among African American Men
    KERRY KILBRIDGE; Fiscal Year: 2007
    ..that the net benefit of prostate cancer screening depends on how men value the common side effects of treatment (impotence, incontinence, and bowel symptoms) as measured using utility assessment...
  39. Smooth Muscle Differential Tissue Function & Diabetes
    Arnold Melman; Fiscal Year: 2007
    ..and erectile function, as well as the contribution of diabetic neuropathy/myopathy to urinary incontinence and impotence. Project #1 will evaluate bladder and erectile function and myocyte tone in vivo, in the same animal...
  40. TRANSDERMAL PROSTAGLANDIN E1 TO TREAT MALE IMPOTENCE
    Larry Nichols; Fiscal Year: 1999
    ..abstract): The proposed study aims to develop a new, reliable and more user-acceptable method for treating male impotence by administering prostaglandin E1 through the surface of the penis...
  41. PATHOGENESIS OF DIABETIC NEUROPATHY 09
    DOUGLAS ISHII; Fiscal Year: 1999
    ..distressing problems include third nerve palsy, muscular weakness, bowel dysfunction, bladder dysfunction, impotence, heart rate abnormalities, severe unremitting pain, diabetic foot, and limb amputation...
  42. Expandibility As A Measure of Fibrosis Induced Impotence
    Daniel Udelson; Fiscal Year: 2004
    ..abstract_text> ..
  43. Mesenchymal Stem Cells for Myocardial Infarction
    Robert Kloner; Fiscal Year: 2006
    ..abstract_text> ..
  44. Biologic Ventricular Assist Device
    Robert Kloner; Fiscal Year: 2004
    ..Identification and characterization of transplants will be carried out with PCR analysis of the Y chromosome (male cells into female host), detailed histologic analysis and immunostaining for muscle cell markers. ..
  45. COLLABORATIVE R01-CARDIAC GRAFTS-FUNCTIONAL ANALYSES
    Robert Kloner; Fiscal Year: 2003
    ....
  46. TOBACCO ADDICTION AND CESSATION ACROSS THE LIFESPAN
    ARTHUR GARVEY; Fiscal Year: 2000
    ..which little is known, such as smoking effects on diabetes, benign prostatic hyperplasia (BPH), osteoarthritis, impotence, and oral health...
  47. 2008 AUA/SBUR Summer Research Conference
    Arthur Burnett; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  48. MONITORING CHEMOTHERAPY IN PROSTATE CANCER BY PROTON NMR
    KRISTEN ZAKIAN; Fiscal Year: 2001
    ..location of the prostate gland, and the morbidity associated with its surgical removal (urinary incontinence, impotence) alternatives to surgical removal are of great practical significance to the practice of urology in males...
  49. NITRIC OXIDE REGULATORY SYSTEM IN THE PENIS
    Arthur Burnett; Fiscal Year: 2002
    ....
  50. REGULATION OF PROSTATE GROWTH BY NEURAL FACTORS
    Kevin McVary; Fiscal Year: 2001
    ..Using this model allows one to explore the limits of understanding prostatic neuroregulation, to explore neurotrophic influences on exocrine gland development, and to possibly uncover novel methods to influence prostate disease. ..
  51. N O S AND NEUROPATHIC AND ENDOTHELIAL INDUCED ED
    Kevin McVary; Fiscal Year: 2002
    ..Results of this research will aid in the understanding of how diabetic neuropathy contributes to sexual dysfunction and elucidate possible mechanisms to prevent them. ..
  52. The Efficacy of TUMT and Neoadjuvant Finasteride for BPH
    Kevin McVary; Fiscal Year: 2005
    ..We are proposing a 3-arm, placebo/sham controlled, randomized clinical trial using changes in symptoms as the primary ..
  53. NEUROPSYCHIATRIC EFFECTS OF TESTOSTERONE IN MEN
    Stuart Seidman; Fiscal Year: 2004
    ..abstract_text> ..
  54. eNOS-Protein Interaction in the Penis
    Biljana Musicki; Fiscal Year: 2007
    ..At the same time, it may suggest a specific eNOS regulatory pathway as a possible new molecular target for treating ED. [unreadable] [unreadable] [unreadable]..
  55. Posttranslational Regulation of eNOS by Estrogen in the Vagina and Clitoris
    Biljana Musicki; Fiscal Year: 2007
    ..At the same time it may advance treatments for multiple disease states associated with endothelial dysfunction and alterations in hormonal milieu. [unreadable] [unreadable] [unreadable]..
  56. FEMALE SEXUAL AROUSAL: CLITORAL AND VAGINAL PHYSIOLOGY
    Abdulmaged Traish; Fiscal Year: 2003
    ....
  57. Sexual Dysfunction and Diabetes:Look AHEAD Sub-Study
    Stephen Schneider; Fiscal Year: 2006
    ..iii) Finally, the proposed sub-study will investigate the relationship between changes in sexual function and quality of life outcomes. ..