schizophrenia

Summary

Summary: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, hallucinations, emotional disharmony, and regressive behavior.

Articles from Journal RESEARCH

Top Publications

  1. pmc Direct measure of the de novo mutation rate in autism and schizophrenia cohorts
    Philip Awadalla
    Department of Pediatrics, Universite de Montreal, Quebec, Canada
    Am J Hum Genet 87:316-24. 2010
  2. doi Disrupted small-world networks in schizophrenia
    Yong Liu
    National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, China
    Brain 131:945-61. 2008
  3. pmc Epigenomic profiling reveals DNA-methylation changes associated with major psychosis
    Jonathan Mill
    Krembil Family Epigenetic Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8, Canada
    Am J Hum Genet 82:696-711. 2008
  4. pmc Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia
    John E Lisman
    Department of Biology, Brandeis University, 415 South Street, Waltham, MA 02454, USA
    Trends Neurosci 31:234-42. 2008
  5. pmc Prenatal infection and schizophrenia: a review of epidemiologic and translational studies
    Alan S Brown
    New York State Psychiatric Institute, New York, NY 10032, USA
    Am J Psychiatry 167:261-80. 2010
  6. pmc Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs
    S Hong Lee
    Queensland Brain Institute, University of Queensland, Brisbane, Australia
    Nat Genet 44:247-50. 2012
  7. pmc Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
    SHAUN M PURCELL
    Nature 460:748-52. 2009
  8. pmc Common variants on chromosome 6p22.1 are associated with schizophrenia
    Jianxin Shi
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94304, USA
    Nature 460:753-7. 2009
  9. pmc The dopamine hypothesis of schizophrenia: version III--the final common pathway
    Oliver D Howes
    Positron Emission Tomography PET Psychiatry Group, Medical Research Council MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, UK
    Schizophr Bull 35:549-62. 2009
  10. doi Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database
    Nicole C Allen
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Nat Genet 40:827-34. 2008

Detail Information

Articles from Journal RESEARCH1

Publications331 found, 100 shown here

  1. pmc Direct measure of the de novo mutation rate in autism and schizophrenia cohorts
    Philip Awadalla
    Department of Pediatrics, Universite de Montreal, Quebec, Canada
    Am J Hum Genet 87:316-24. 2010
    ..We hypothesized that deleterious DNMs may play a role in cases of autism spectrum disorders (ASD) and schizophrenia (SCZ), two etiologically heterogeneous disorders with significantly reduced reproductive fitness...
  2. doi Disrupted small-world networks in schizophrenia
    Yong Liu
    National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, China
    Brain 131:945-61. 2008
    ..studies have provided consistent evidence of 'dysfunctional connectivity' among the brain regions in schizophrenia; however, little is known about whether or not this dysfunctional connectivity causes disruption of the ..
  3. pmc Epigenomic profiling reveals DNA-methylation changes associated with major psychosis
    Jonathan Mill
    Krembil Family Epigenetic Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8, Canada
    Am J Hum Genet 82:696-711. 2008
    Epigenetic misregulation is consistent with various non-Mendelian features of schizophrenia and bipolar disorder...
  4. pmc Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia
    John E Lisman
    Department of Biology, Brandeis University, 415 South Street, Waltham, MA 02454, USA
    Trends Neurosci 31:234-42. 2008
    Many risk genes interact synergistically to produce schizophrenia and many neurotransmitter interactions have been implicated. We have developed a circuit-based framework for understanding gene and neurotransmitter interactions...
  5. pmc Prenatal infection and schizophrenia: a review of epidemiologic and translational studies
    Alan S Brown
    New York State Psychiatric Institute, New York, NY 10032, USA
    Am J Psychiatry 167:261-80. 2010
    ..investigations has provided evidence that gestational exposure to infection contributes to the etiology of schizophrenia. In recent years, these studies have moved from ecologic designs, which ascertain infection based on epidemics ..
  6. pmc Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs
    S Hong Lee
    Queensland Brain Institute, University of Queensland, Brisbane, Australia
    Nat Genet 44:247-50. 2012
    b>Schizophrenia is a complex disorder caused by both genetic and environmental factors...
  7. pmc Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
    SHAUN M PURCELL
    Nature 460:748-52. 2009
    b>Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80%...
  8. pmc Common variants on chromosome 6p22.1 are associated with schizophrenia
    Jianxin Shi
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94304, USA
    Nature 460:753-7. 2009
    b>Schizophrenia, a devastating psychiatric disorder, has a prevalence of 0.5-1%, with high heritability (80-85%) and complex transmission...
  9. pmc The dopamine hypothesis of schizophrenia: version III--the final common pathway
    Oliver D Howes
    Positron Emission Tomography PET Psychiatry Group, Medical Research Council MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, UK
    Schizophr Bull 35:549-62. 2009
    The dopamine hypothesis of schizophrenia has been one of the most enduring ideas in psychiatry...
  10. doi Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database
    Nicole C Allen
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Nat Genet 40:827-34. 2008
    In an effort to pinpoint potential genetic risk factors for schizophrenia, research groups worldwide have published over 1,000 genetic association studies with largely inconsistent results...
  11. pmc Genome-wide association analysis identifies 13 new risk loci for schizophrenia
    Stephan Ripke
    1 Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA 2 Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA 3
    Nat Genet 45:1150-9. 2013
    b>Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact...
  12. pmc Common variants conferring risk of schizophrenia
    Hreinn Stefansson
    deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
    Nature 460:744-7. 2009
    b>Schizophrenia is a complex disorder, caused by both genetic and environmental factors and their interactions...
  13. pmc Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia
    M F Egan
    Clinical Brain Disorders Branch, Building 10, Center Drive, National Institute of Mental Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:6917-22. 2001
    Abnormalities of prefrontal cortical function are prominent features of schizophrenia and have been associated with genetic risk, suggesting that susceptibility genes for schizophrenia may impact on the molecular mechanisms of prefrontal ..
  14. pmc Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study
    Paul Lichtenstein
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Lancet 373:234-9. 2009
    Whether schizophrenia and bipolar disorder are the clinical outcomes of discrete or shared causative processes is much debated in psychiatry...
  15. pmc Neuregulin 1 and susceptibility to schizophrenia
    Hreinn Stefansson
    deCODE Genetics, Reykjavik, Iceland
    Am J Hum Genet 71:877-92. 2002
    The cause of schizophrenia is unknown, but it has a significant genetic component...
  16. ncbi Prefrontal dopamine D1 receptors and working memory in schizophrenia
    Anissa Abi-Dargham
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute, New York, New York 10032, USA
    J Neurosci 22:3708-19. 2002
    ..The defective ability of patients with schizophrenia at working memory tasks is a core feature of this illness...
  17. pmc Functional connectivity and brain networks in schizophrenia
    Mary Ellen Lynall
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom
    J Neurosci 30:9477-87. 2010
    b>Schizophrenia has often been conceived as a disorder of connectivity between components of large-scale brain networks...
  18. doi The environment and schizophrenia
    Jim Van Os
    European Graduate School for Neuroscience, SEARCH, Maastricht University Medical Centre, 6200 MD Maastricht, The Netherlands
    Nature 468:203-12. 2010
    ..Longitudinal research is needed to uncover gene-environment interplay that determines how expression of vulnerability in the general population may give rise to more severe psychopathology...
  19. doi Neuroinflammation in schizophrenia-related psychosis: a PET study
    Janine Doorduin
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Nucl Med 50:1801-7. 2009
    b>Schizophrenia is a chronic and disabling brain disease characterized by psychotic episodes with unknown etiology. It is suggested that neuroinflammation plays a role in the pathophysiology of schizophrenia...
  20. ncbi A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time?
    Sukanta Saha
    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol Q4076, Australia
    Arch Gen Psychiatry 64:1123-31. 2007
    Despite improvements in mental health services in recent decades, it is unclear whether the risk of mortality in schizophrenia has changed over time.
  21. pmc Modelling schizophrenia using human induced pluripotent stem cells
    Kristen J Brennand
    Salk Institute for Biological Studies, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla California 92037, USA
    Nature 473:221-5. 2011
    b>Schizophrenia (SCZD) is a debilitating neurological disorder with a world-wide prevalence of 1%; there is a strong genetic component, with an estimated heritability of 80-85%...
  22. doi Abnormal neural oscillations and synchrony in schizophrenia
    Peter J Uhlhaas
    Department of Neurophysiology, Max Planck Institute for Brain Research, Frankfurt am Main, 60528, Germany
    Nat Rev Neurosci 11:100-13. 2010
    ..in the synchronized oscillatory activity of neurons may have a central role in the pathophysiology of schizophrenia. Neural oscillations are a fundamental mechanism for the establishment of precise temporal relationships ..
  23. pmc Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia
    Susan Whitfield-Gabrieli
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 106:1279-84. 2009
    ..which typically exhibits greater activation during rest than during task, in patients in the early phase of schizophrenia and in young first-degree relatives of persons with schizophrenia...
  24. doi Disrupted axonal fiber connectivity in schizophrenia
    Andrew Zalesky
    Melbourne Neuropsychiatry Centre, The University of Melbourne, Melbourne, Victoria VIC, Australia
    Biol Psychiatry 69:80-9. 2011
    b>Schizophrenia is believed to result from abnormal functional integration of neural processes thought to arise from aberrant brain connectivity...
  25. doi Identification of loci associated with schizophrenia by genome-wide association and follow-up
    Michael C O'Donovan
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 40:1053-5. 2008
    We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10(-5) in up to 16,726 additional subjects...
  26. ncbi Chlorpromazine equivalent doses for the newer atypical antipsychotics
    Scott W Woods
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, CT 06519, USA
    J Clin Psychiatry 64:663-7. 2003
    ..Several clinical and research applications require an estimation of therapeutic dose equivalence across antipsychotic medications. Since the advent of the newer atypical antipsychotics, new dose equivalent estimations have been needed...
  27. pmc The nature of dopamine dysfunction in schizophrenia and what this means for treatment
    Oliver D Howes
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, Camberwell, UK
    Arch Gen Psychiatry 69:776-86. 2012
    Current drug treatments for schizophrenia are inadequate for many patients, and despite 5 decades of drug discovery, all of the treatments rely on the same mechanism: dopamine D(2) receptor blockade...
  28. ncbi Effectiveness of antipsychotic drugs in patients with chronic schizophrenia
    Jeffrey A Lieberman
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    N Engl J Med 353:1209-23. 2005
    ..We compared a first-generation antipsychotic, perphenazine, with several newer drugs in a double-blind study...
  29. pmc Perceptual organization impairment in schizophrenia and associated brain mechanisms: review of research from 2005 to 2010
    Steven M Silverstein
    Division of Schizophrenia Research, University Behavioral HealthCare, University of Medicine and Dentistry of New Jersey, 151 CentennialAvenue, Piscataway, NJ 08854, USA
    Schizophr Bull 37:690-9. 2011
    ..Impairments in PO have been demonstrated in schizophrenia since the 1960s and have been linked to several illness-related factors including poor premorbid functioning, ..
  30. pmc Exome sequencing supports a de novo mutational paradigm for schizophrenia
    Bin Xu
    Department of Psychiatry, Columbia University, New York, New York, USA
    Nat Genet 43:864-8. 2011
    Despite its high heritability, a large fraction of individuals with schizophrenia do not have a family history of the disease (sporadic cases)...
  31. ncbi Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies
    Patrick F Sullivan
    Department of Genetics, University of North Carolina at Chapel Hill, 27599, USA
    Arch Gen Psychiatry 60:1187-92. 2003
    There are many published twin studies of schizophrenia. Although these studies have been reviewed previously, to our knowledge, no review has provided quantitative summary estimates of the impact of genes and environment on liability to ..
  32. doi Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis
    Stefan Leucht
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Lancet 373:31-41. 2009
    ..whether second-generation antipsychotic drugs are better than first-generation antipsychotic drugs, we did a meta-analysis of randomised controlled trials to compare the effects of these two types of drugs in patients with schizophrenia.
  33. pmc Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis
    Nigel M Williams
    MRC Centre in Neuropsychiatric Genetics and Genomics and Department of Psychological Medicine and Neurology, Cardiff University School of Medicine, Cardiff, UK
    Lancet 376:1401-8. 2010
    ..We aimed to establish whether burden of CNVs was increased in ADHD, and to investigate whether identified CNVs were enriched for loci previously identified in autism and schizophrenia.
  34. doi Upregulation of dicer and microRNA expression in the dorsolateral prefrontal cortex Brodmann area 46 in schizophrenia
    Danielle M Santarelli
    Schizophrenia Research Institute, Sydney, Australia
    Biol Psychiatry 69:180-7. 2011
    ..We hypothesize that abnormal miRNA levels contribute to the complex global changes in gene expression that underlie the pathophysiology of schizophrenia.
  35. ncbi Neurocognitive deficit in schizophrenia: a quantitative review of the evidence
    R W Heinrichs
    Department of Psychology, York University, Toronto, Ontario, Canada
    Neuropsychology 12:426-45. 1998
    The neurocognitive literature on test performance in schizophrenia is reviewed quantitatively...
  36. ncbi Aberrant "default mode" functional connectivity in schizophrenia
    Abigail G Garrity
    Trinity College, Hartford, CT, USA
    Am J Psychiatry 164:450-7. 2007
    ..of brain function and is of interest because its component brain regions are believed to be abnormal in schizophrenia. It was hypothesized that the default mode network would show abnormal activation and connectivity in patients ..
  37. doi Increased exonic de novo mutation rate in individuals with schizophrenia
    Simon L Girard
    Centre of Excellence in Neuromics of Université de Montréal, Centre Hospitalier de L Universite de Montreal Research Center, Montreal, Quebec, Canada
    Nat Genet 43:860-3. 2011
    b>Schizophrenia is a severe psychiatric disorder that profoundly affects cognitive, behavioral and emotional processes...
  38. doi After GWAS: searching for genetic risk for schizophrenia and bipolar disorder
    Elliot S Gershon
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, USA
    Am J Psychiatry 168:253-6. 2011
    ..of a substantial proportion of common disease, and rare CNVs have been found to be potent risk factors in schizophrenia and autism. Another approach is to "parse the genome," i.e...
  39. pmc Dysconnection in schizophrenia: from abnormal synaptic plasticity to failures of self-monitoring
    Klaas E Stephan
    Schizophr Bull 35:509-27. 2009
    Over the last 2 decades, a large number of neurophysiological and neuroimaging studies of patients with schizophrenia have furnished in vivo evidence for dysconnectivity, ie, abnormal functional integration of brain processes...
  40. pmc A systematic review of the prevalence of schizophrenia
    Sukanta Saha
    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Australia
    PLoS Med 2:e141. 2005
    Understanding the prevalence of schizophrenia has important implications for both health service planning and risk factor epidemiology...
  41. pmc Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes
    Juan E Belforte
    Unit on Genetics of Cognition and Behavior, Mood and Anxiety Disorders Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Nat Neurosci 13:76-83. 2010
    Cortical GABAergic dysfunction may underlie the pathophysiology of psychiatric disorders, including schizophrenia. Here, we characterized a mouse strain in which the essential NR1 subunit of the NMDA receptor (NMDAR) was selectively ..
  42. doi Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis
    Stefan Leucht
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Klinikum rechts der Isar, Munich, Germany
    Lancet 382:951-62. 2013
    The question of which antipsychotic drug should be preferred for the treatment of schizophrenia is controversial, and conventional pairwise meta-analyses cannot provide a hierarchy based on the randomised evidence...
  43. doi Aberrant frontal and temporal complex network structure in schizophrenia: a graph theoretical analysis
    Martijn P van den Heuvel
    Department of Psychiatry, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
    J Neurosci 30:15915-26. 2010
    ..Here, we demonstrate that schizophrenia involves an aberrant topology of the structural infrastructure of the brain network...
  44. doi Increased inflammatory markers identified in the dorsolateral prefrontal cortex of individuals with schizophrenia
    S G Fillman
    Schizophrenia Research Institute, Sydney, New South Wales, Australia
    Mol Psychiatry 18:206-14. 2013
    Upregulation of the immune response may be involved in the pathogenesis of schizophrenia with changes occurring in both peripheral blood and brain tissue...
  45. doi Acquired self-control of insula cortex modulates emotion recognition and brain network connectivity in schizophrenia
    Sergio Ruiz
    Institute of Medical Psychology and Behavioral Neurobiology, University of Tubingen, Germany
    Hum Brain Mapp 34:200-12. 2013
    ..The objectives of the present study were to train schizophrenia patients to achieve volitional control of bilateral anterior insula cortex on multiple days, and to explore ..
  46. ncbi Synaptic plasticity and dysconnection in schizophrenia
    Klaas E Stephan
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, United Kingdom
    Biol Psychiatry 59:929-39. 2006
    Current pathophysiological theories of schizophrenia highlight the role of altered brain connectivity...
  47. pmc A review of MRI findings in schizophrenia
    M E Shenton
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Harvard Medical School, Brockton, MA 02301, USA
    Schizophr Res 49:1-52. 2001
    After more than 100 years of research, the neuropathology of schizophrenia remains unknown and this is despite the fact that both Kraepelin (1919/1971: Kraepelin, E., 1919/1971. Dementia praecox. Churchill Livingston Inc...
  48. doi Adjunctive intranasal oxytocin reduces symptoms in schizophrenia patients
    David Feifel
    Department of Psychiatry, University of California, San Diego Medical Center, San Diego, California 92103 8218, USA
    Biol Psychiatry 68:678-80. 2010
    ..Both human and animal studies suggest oxytocin may have antipsychotic properties. Therefore, we conducted a clinical trial to directly test this notion...
  49. pmc The 2009 schizophrenia PORT psychopharmacological treatment recommendations and summary statements
    Robert W Buchanan
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Schizophr Bull 36:71-93. 2010
    In light of the large number of studies published since the 2004 update of Schizophrenia Patient Outcomes Research Team psychopharmacological treatment recommendations, we conducted an extensive literature review to determine whether the ..
  50. ncbi Recent advances in the phencyclidine model of schizophrenia
    D C Javitt
    Department of Psychiatry, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, N Y
    Am J Psychiatry 148:1301-8. 1991
    Phencyclidine (PCP, "angel dust") induces a psychotomimetic state that closely resembles schizophrenia. As opposed to amphetamine-induced psychosis, PCP-induced psychosis incorporates both positive (e.g...
  51. pmc Copy number variants in schizophrenia: confirmation of five previous findings and new evidence for 3q29 microdeletions and VIPR2 duplications
    Douglas F Levinson
    Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA 94304 5797, USA
    Am J Psychiatry 168:302-16. 2011
    To evaluate previously reported associations of copy number variants (CNVs) with schizophrenia and to identify additional associations, the authors analyzed CNVs in the Molecular Genetics of Schizophrenia study (MGS) and additional ..
  52. doi Discriminative analysis of resting-state functional connectivity patterns of schizophrenia using low dimensional embedding of fMRI
    Hui Shen
    College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan 410073, China
    Neuroimage 49:3110-21. 2010
    Recently, a functional disconnectivity hypothesis of schizophrenia has been proposed for the physiological explanation of behavioral syndromes of this complex mental disorder...
  53. pmc Copy number variations of chromosome 16p13.1 region associated with schizophrenia
    A Ingason
    deCODE Genetics, Reykjavik, Iceland
    Mol Psychiatry 16:17-25. 2011
    ..As genomic copy number variants found in these two disorders may also associate with schizophrenia, we examined 4345 schizophrenia patients and 35,079 controls from 8 European populations for duplications and ..
  54. pmc A method for functional network connectivity among spatially independent resting-state components in schizophrenia
    Madiha J Jafri
    Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT 06106, USA
    Neuroimage 39:1666-81. 2008
    ..evaluating FNC and apply it to functional magnetic resonance imaging (fMRI) data collected from persons with schizophrenia and healthy controls...
  55. pmc Schizophrenia is associated with an increase in cortical microRNA biogenesis
    N J Beveridge
    Schizophrenia Research Institute, Sydney, NSW, Australia
    Mol Psychiatry 15:1176-89. 2010
    ..analysis of the superior temporal gyrus and the dorsolateral prefrontal cortex revealed a significant schizophrenia-associated increase in global microRNA expression...
  56. ncbi Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders
    H M Lachman
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Pharmacogenetics 6:243-50. 1996
    ..in which abnormalities in catecholamine neurotransmission are believed to occur, including mood disorders, schizophrenia, obsessive compulsive disorder, alcohol and substance abuse, and attention deficit hyperactivity disorder...
  57. ncbi Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia
    Effat S Emamian
    The Rockefeller University, Laboratory of Human Neurogenetics, 1230 York Avenue, Box 313, New York, New York 10021, USA
    Nat Genet 36:131-7. 2004
    ..Here, we provide evidence that this signaling pathway also has a role in schizophrenia. Specifically, we present convergent evidence for a decrease in AKT1 protein levels and levels of ..
  58. pmc Spatial and temporal mapping of de novo mutations in schizophrenia to a fetal prefrontal cortical network
    Suleyman Gulsuner
    Department of Medicine and Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Cell 154:518-29. 2013
    Genes disrupted in schizophrenia may be revealed by de novo mutations in affected persons from otherwise healthy families...
  59. doi CNVs conferring risk of autism or schizophrenia affect cognition in controls
    Hreinn Stefansson
    1 deCODE Genetics Amgen, Sturlugata 8, IS 101 Reykjavik, Iceland 2
    Nature 505:361-6. 2014
    In a small fraction of patients with schizophrenia or autism, alleles of copy-number variants (CNVs) in their genomes are probably the strongest factors contributing to the pathogenesis of the disease...
  60. doi A systematic review and meta-analysis of the psychosis continuum: evidence for a psychosis proneness-persistence-impairment model of psychotic disorder
    J van Os
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Psychol Med 39:179-95. 2009
    ....
  61. pmc Meta-analysis of 41 functional neuroimaging studies of executive function in schizophrenia
    Michael J Minzenberg
    Department of Psychiatry, University of California Davis School of Medicine, Sacramento, CA 95817, USA
    Arch Gen Psychiatry 66:811-22. 2009
    Prefrontal cortical dysfunction is frequently reported in schizophrenia. It remains unclear whether this represents the coincidence of several prefrontal region- and process-specific impairments or a more unitary dysfunction in a ..
  62. pmc Neuregulin 1 in neural development, synaptic plasticity and schizophrenia
    Lin Mei
    Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Nat Rev Neurosci 9:437-52. 2008
    b>Schizophrenia is a highly debilitating mental disorder that affects approximately 1% of the general population, yet it continues to be poorly understood...
  63. pmc Mobile Assessment and Treatment for Schizophrenia (MATS): a pilot trial of an interactive text-messaging intervention for medication adherence, socialization, and auditory hallucinations
    Eric Granholm
    Psychology Service, VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Schizophr Bull 38:414-25. 2012
    Mobile Assessment and Treatment for Schizophrenia (MATS) employs ambulatory monitoring methods and cognitive behavioral therapy interventions to assess and improve outcomes in consumers with schizophrenia through mobile phone text ..
  64. doi Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2
    Wei hua Yue
    Institute of Mental Health, Peking University, Beijing, China
    Nat Genet 43:1228-31. 2011
    To identify susceptibility loci for schizophrenia, we performed a two-stage genome-wide association study (GWAS) of schizophrenia in the Han Chinese population (GWAS: 746 individuals with schizophrenia and 1,599 healthy controls; ..
  65. doi A meta-analysis of cognitive remediation for schizophrenia: methodology and effect sizes
    Til Wykes
    Institute of Psychiatry, King s College London, UK
    Am J Psychiatry 168:472-85. 2011
    Cognitive remediation therapy for schizophrenia was developed to treat cognitive problems that affect functioning, but the treatment effects may depend on the type of trial methodology adopted...
  66. pmc Altered resting state complexity in schizophrenia
    Danielle S Bassett
    Complex Systems Group, Department of Physics, University of California, Santa Barbara, CA 93106, United States
    Neuroimage 59:2196-207. 2012
    ..human brain's activity and connectivity varies over temporal scales and is altered in disease states such as schizophrenia. Using a multi-level analysis of spontaneous low-frequency fMRI data stretching from the activity of ..
  67. pmc Head-to-head comparisons of metabolic side effects of second generation antipsychotics in the treatment of schizophrenia: a systematic review and meta-analysis
    Christine Rummel-Kluge
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie der Technischen Universitat Munchen, Klinikum rechts der Isar, Möhlstr 26, 81675 Munchen, Germany
    Schizophr Res 123:225-33. 2010
    ..We conducted a meta-analysis of studies comparing the metabolic side effects of the following SGAs head-to-head: amisulpride, aripiprazole, clozapine, olanzapine, quetiapine, risperidone, sertindole, ziprasidone, zotepine...
  68. pmc De novo gene mutations highlight patterns of genetic and neural complexity in schizophrenia
    Bin Xu
    Department of Psychiatry, Columbia University, New York, NY, USA
    Nat Genet 44:1365-9. 2012
    To evaluate evidence for de novo etiologies in schizophrenia, we sequenced at high coverage the exomes of families recruited from two populations with distinct demographic structures and history...
  69. ncbi The principal features and mechanisms of dopamine modulation in the prefrontal cortex
    Jeremy K Seamans
    Department of Physiology, MUSC, 173 Ashley Avenue, Suite 403, Charleston, SC 29425, USA
    Prog Neurobiol 74:1-58. 2004
    ..and its dysfunctions may underlie positive and negative symptoms and cognitive deficits associated with schizophrenia. Despite intense research, there is still a lack of clear understanding of the basic principles of actions of ..
  70. pmc "A disease like any other"? A decade of change in public reactions to schizophrenia, depression, and alcohol dependence
    Bernice A Pescosolido
    Schuessler Institute for Social Research, Indiana University, 1022 East Third St, Bloomington, IN 47405, USA
    Am J Psychiatry 167:1321-30. 2010
    ..The authors examined the impact of this approach with a 10-year comparison of public endorsement of treatment and prejudice...
  71. pmc The social-emotional processing stream: five core constructs and their translational potential for schizophrenia and beyond
    Kevin N Ochsner
    Department of Psychology, Columbia University, New York, New York 10027, USA
    Biol Psychiatry 64:48-61. 2008
    ..basic mechanisms of dysfunction and their relation to cognitive deficits, such as thought disorder in schizophrenia. The recent emergence of Social Cognitive and Affective Neuroscience has paved the way for similar progress to ..
  72. pmc Emotional experience in patients with schizophrenia revisited: meta-analysis of laboratory studies
    Alex S Cohen
    Department of Psychology, Louisiana State University, 206 Audubon Hall Baton Rouge, LA 708080, USA
    Schizophr Bull 36:143-50. 2010
    Our understanding of the emotion deficits in schizophrenia is limited...
  73. pmc Large recurrent microdeletions associated with schizophrenia
    Hreinn Stefansson
    CNS Division, deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
    Nature 455:232-6. 2008
    ..may explain, in part, why common variants have not been found that confer risk of disorders such as autism, schizophrenia and mental retardation...
  74. ncbi Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia
    Shitij Kapur
    Clarke Division of the Centre for Addiction and Mental Health, 250 College St, Toronto, Ont M5T 1R8, Canada
    Am J Psychiatry 160:13-23. 2003
    The clinical hallmark of schizophrenia is psychosis...
  75. ncbi The endophenotype concept in psychiatry: etymology and strategic intentions
    Irving I Gottesman
    Department of Psychiatry, University of Minnesota Medical School, Minneapolis 55454, USA
    Am J Psychiatry 160:636-45. 2003
    ..The authors discuss the etymology and strategy behind the use of endophenotypes in neuropsychiatric research and, more generally, in research on other diseases with complex genetics...
  76. ncbi DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling
    J Kirsty Millar
    Medical Genetics Section, Molecular Medicine Centre, University of Edinburgh, Edinburgh EH4 2XU, UK
    Science 310:1187-91. 2005
    The disrupted in schizophrenia 1 (DISC1) gene is a candidate susceptibility factor for schizophrenia, but its mechanistic role in the disorder is unknown...
  77. ncbi A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development
    Atsushi Kamiya
    Department of Psychiatry Neurobiology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, CMSC 8 117, Baltimore, MD 21287, USA
    Nat Cell Biol 7:1167-78. 2005
    Disrupted-In-Schizophrenia-1 (DISC1), originally identified at the breakpoint of a chromosomal translocation that is linked to a rare familial schizophrenia, has been genetically implicated in schizophrenia in other populations...
  78. pmc De novo mutations in schizophrenia implicate synaptic networks
    Menachem Fromer
    1 Division of Psychiatric Genomics in the Department of Psychiatry, and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA 2 Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Nature 506:179-84. 2014
    Inherited alleles account for most of the genetic risk for schizophrenia. However, new (de novo) mutations, in the form of large chromosomal copy number changes, occur in a small fraction of cases and disproportionally disrupt genes ..
  79. doi Schizophrenia, neuroimaging and connectomics
    Alex Fornito
    Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health, Melbourne, Australia
    Neuroimage 62:2296-314. 2012
    b>Schizophrenia is frequently characterized as a disorder of brain connectivity...
  80. pmc Impaired hippocampal-prefrontal synchrony in a genetic mouse model of schizophrenia
    Torfi Sigurdsson
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Nature 464:763-7. 2010
    ..connectivity between brain areas have been postulated as an important pathophysiological mechanism underlying schizophrenia. In particular, macroscopic measurements of brain activity in patients suggest that functional connectivity ..
  81. ncbi Disruption of two novel genes by a translocation co-segregating with schizophrenia
    J K Millar
    Medical Genetics Section, Department of Medical Sciences, The University of Edinburgh, Molecular Medicine Centre and MRC Human Genetics Unit, both at Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Hum Mol Genet 9:1415-23. 2000
    A balanced (1;11)(q42.1;q14.3) translocation segregates with schizophrenia and related psychiatric disorders in a large Scottish family (maximum LOD = 6.0)...
  82. pmc Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1
    Hanna Jaaro-Peled
    Department of Psychiatry and Behavioral Neurosciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Trends Neurosci 32:485-95. 2009
    b>Schizophrenia (SZ) is primarily an adult psychiatric disorder in which disturbances caused by susceptibility genes and environmental insults during early neurodevelopment initiate neurophysiological changes over a long time course, ..
  83. doi Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia
    Tom Walsh
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Science 320:539-43. 2008
    b>Schizophrenia is a devastating neurodevelopmental disorder whose genetic influences remain elusive. We hypothesize that individually rare structural variants contribute to the illness...
  84. ncbi Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia
    L M Camargo
    Merck Research Labs, Merck and Co, Boston, MA 02115, USA
    Mol Psychiatry 12:74-86. 2007
    Disrupted in Schizophrenia 1 (DISC1) is a schizophrenia risk gene associated with cognitive deficits in both schizophrenics and the normal ageing population...
  85. pmc Temporal lobe and "default" hemodynamic brain modes discriminate between schizophrenia and bipolar disorder
    Vince D Calhoun
    Olin Neuropsychiatry Research Center, Institute of Living, Hartford, Connecticut, USA
    Hum Brain Mapp 29:1265-75. 2008
    b>Schizophrenia and bipolar disorder are currently diagnosed on the basis of psychiatric symptoms and longitudinal course...
  86. pmc Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family
    D H Blackwood
    University Department of Psychiatry, Royal Edinburgh Hospital and University of Edinburgh, Medical Genetics Section, Molecular Medicine Centre, Edinburgh, United Kingdom
    Am J Hum Genet 69:428-33. 2001
    A family with a (1;11)(q42;q14.3) translocation significantly linked to a clinical phenotype that includes schizophrenia and affective disorders is described. This translocation generates a LOD score of 3...
  87. doi Global pattern of experienced and anticipated discrimination against people with schizophrenia: a cross-sectional survey
    Graham Thornicroft
    Health Service and Population Research Department, Institute of Psychiatry, King s College London, UK
    Lancet 373:408-15. 2009
    Many people with schizophrenia experience stigma caused by other people's knowledge, attitudes, and behaviour; this can lead to impoverishment, social marginalisation, and low quality of life...
  88. pmc Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder
    Emma L Dempster
    MRC Social, Genetic and Developmental Psychiatry Centre, King s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Hum Mol Genet 20:4786-96. 2011
    Studies of the major psychoses, schizophrenia (SZ) and bipolar disorder (BD), have traditionally focused on genetic and environmental risk factors, although more recent work has highlighted an additional role for epigenetic processes in ..
  89. pmc A polygenic burden of rare disruptive mutations in schizophrenia
    SHAUN M PURCELL
    1 Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA 2 Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA 3 Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA 4 Analytic and Translational Genetics Unit, Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA 5 Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Nature 506:185-90. 2014
    b>Schizophrenia is a common disease with a complex aetiology, probably involving multiple and heterogeneous genetic factors...
  90. doi Short-term effects of antipsychotic treatment on cerebral function in drug-naive first-episode schizophrenia revealed by "resting state" functional magnetic resonance imaging
    Su Lui
    Huaxi MR Research Center, Department of Radiology, State Key Lab of Biotherapy, West China Hospital of Sichuan University, Chengdu, China
    Arch Gen Psychiatry 67:783-92. 2010
    ..Studying cerebral function in antipsychotic-naive patients with schizophrenia before and after pharmacotherapy can enhance understanding of the therapeutic mechanisms of these clinically ..
  91. pmc Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls
    Kristin K Nicodemus
    Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 67:991-1001. 2010
    NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.
  92. pmc Schizophrenia gene networks and pathways and their applications for novel candidate gene selection
    Jingchun Sun
    Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 5:e11351. 2010
    b>Schizophrenia (SZ) is a heritable, complex mental disorder. We have seen limited success in finding causal genes for schizophrenia from numerous conventional studies...
  93. doi Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries
    Hywel J Williams
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Hum Mol Genet 20:387-91. 2011
    ..association studies point strongly to a partial overlap in the genes that contribute susceptibility to schizophrenia and bipolar disorder (BD)...
  94. pmc Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder
    H J Williams
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Mol Psychiatry 16:429-41. 2011
    ..reported evidence for association between rs1344706 within ZNF804A (encoding zinc-finger protein 804A) and schizophrenia (P=1.61 × 10(-7)), and stronger evidence when the phenotype was broadened to include bipolar disorder (P=9...
  95. doi From maps to mechanisms through neuroimaging of schizophrenia
    Andreas Meyer-Lindenberg
    Central Institute of Mental Health, University of Heidelberg Medical Faculty Mannheim, J5, 68159 Mannheim, Germany
    Nature 468:194-202. 2010
    Functional and structural brain imaging has identified neural and neurotransmitter systems involved in schizophrenia and their link to cognitive and behavioural disturbances such as psychosis...
  96. pmc De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia
    G Kirov
    Department of Psychological Medicine and Neurology, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
    Mol Psychiatry 17:142-53. 2012
    ..of rare, recurrent genomic copy number variants (CNVs) are known to substantially increase susceptibility to schizophrenia. As a consequence of the low fecundity in people with schizophrenia and other neurodevelopmental phenotypes to ..
  97. pmc Conscious and subliminal conflicts in normal subjects and patients with schizophrenia: the role of the anterior cingulate
    Stanislas Dehaene
    Institut National de la Santé et de la Recherche Médicale Commissariat à l Energie Atomique Unit 562 Cognitive Neuroimaging, Service Hospitalier Frederic Joliot, Orsay Cedex, France
    Proc Natl Acad Sci U S A 100:13722-7. 2003
    ..The same task was studied in normal subjects and in patients with schizophrenia in whom the ACC and prefrontal cortex are thought to be dysfunctional...
  98. pmc Runs of homozygosity reveal highly penetrant recessive loci in schizophrenia
    Todd Lencz
    Department of Psychiatry Research, Zucker Hillside Hospital, North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Proc Natl Acad Sci U S A 104:19942-7. 2007
    ..this phenomenon in healthy individuals and to use this genomic feature to identify genetic risk loci for schizophrenia (SCZ)...
  99. ncbi DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation
    Jill A Morris
    Department of Neuroscience, Merck Research Laboratories, West Point, PA 19486, USA
    Hum Mol Genet 12:1591-608. 2003
    Disrupted-In-Schizophrenia 1 (DISC1) is a novel gene associated with schizophrenia by multiple genetic studies...

Research Grants86

  1. Psychiatric Illness: Multigene Expression Classification
    JAMES CLELLAND; Fiscal Year: 2005
    This proposal is designed to produce data for the development of a biological classification of schizophrenia and bipolar disorder, based on high density microarray measurements of transcribed white blood cell (leukocyte) mRNA...
  2. COMPUTERIZED IMAGE ANALYSES OF MR SCANS IN SCHIZOPHRENIA
    Martha Shenton; Fiscal Year: 2009
    ..Previously the focus of research was on gray matter abnormalities in schizophrenia. In the current five-year application, we now turn to the investigation of white matter abnormalities in ..
  3. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Title: Internal Monitoring of Eye Movement in Schizophrenia Number: 10-EI-0016 Summary: Background: - Researchers are studying how humans are able to move our eyes to a ..
  4. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Title: Internal Monitoring of Eye Movement in Schizophrenia Number: 10-EI-0016 Summary: Background: - Researchers are studying how humans are able to move our eyes to a ..
  5. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  6. Tyrosine Availability Influences Mesocortico-Limbic Catecholamines
    GEORGE EUGENE JASKIW; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Schizophrenia is a complex disorder affecting behavior, perception and thinking. It is inadequately treated by existing medications...
  7. Patient-Derived Stem Cells for Phosphoproteomic Profiling Neuropsychopathology
    Dieter A Wolf; Fiscal Year: 2011
    ..analyses have been performed on post-mortem brain samples &compared with controls &patients with schizophrenia, but no clear distinction between neural subtypes, glia, &surrounding vascular cells has been evident (Kim ..
  8. Cre, Dre Dual Lineage Model for Calcium Imaging and Optogenetic Manipulations
    Petr Tvrdik; Fiscal Year: 2013
    ..disease, Parkinson's disease, multiple sclerosis, as well as obsessive compulsive disorder and schizophrenia. Progress in understanding the causes of these diseases would be much faster if better tools were available ..
  9. Regulation of AKAP79 Postsynaptic Membrane Targeting
    MARK L DELL'ACQUA; Fiscal Year: 2012
    ..disorders such as Alzheimer's and epilepsy and mental health disorders such as Down syndrome and schizophrenia. These same pathways also have relevance for understanding how excessive glutamate receptor activation leads ..
  10. Functional Neuroimaging of Individual Differences in Affect and Motivation
    BRIAN JAMES MICKEY; Fiscal Year: 2013
    ..cortex that underlies sound perception, and in a related study, he investigated auditory processing in schizophrenia. He continued his training in psychiatry residency and fellowship at the University of Michigan, during which ..
  11. Glutamate receptor recruitment to new synapses in vivo
    PHILIP ERIC WASHBOURNE; Fiscal Year: 2013
    ..of synapses are thought to be at the basis of nervous system disorders such as autism, mental retardation and schizophrenia. We propose to study two members of a family of genes, the Synaptic Cell Adhesion Molecules (SynCAMs) 1 and 2, ..
  12. Environmental Risk Factors for Copy Number Variation in Human Chromosomes
    THOMAS EDWARD WILSON; Fiscal Year: 2010
    ..well known to be a major cause of genetic and developmental disorders, including mental retardation, autism, schizophrenia, epilepsy, cleft palate and many others...
  13. The Role of Astrocytes in Cortical Interneuron Development
    KAREN MULLER SMITH; Fiscal Year: 2013
    ..particularly parvalbumin (PV) expressing interneurons, is implicated in severe psychiatric disorders including schizophrenia, bipolar depression, and Tourette syndrome...
  14. Parvalbumin-Containing Neurons in Schizophrenia
    Tsung Ung W Woo; Fiscal Year: 2013
    ..of inhibitory neurons that contain the calcium-binding protein parvalbumin (PV) are functionally altered in schizophrenia (SZ)...
  15. A Computational Framework for Mapping Long Range Genetic Circuits
    Tolga Tasdizen; Fiscal Year: 2010
    ..where dysregulation of circuitry has been implicated in the most devastating mental illnesses, depression, schizophrenia and autism...
  16. Design and Synthesis of Anxioselective Anxiolytics
    James M Cook; Fiscal Year: 2010
    ..known to occur in many anxiety disorders including panic disorder, epilepsy, hypersensitive behavior, phobias, schizophrenia, alcoholism, Anglemans syndrome and Rhetts syndrome, as well as effects which lead to/or complicate drug abuse...
  17. Parental age at birth and risk of adult-onset cancer in female offspring
    Yani Lu; Fiscal Year: 2013
    ..have shown that increased paternal age at birth is associated with childhood and adolescent disorders such as schizophrenia, childhood leukemias and nervous system tumors...
  18. KINETICS OF DRUG MACROMOLECULE COMPLEX FORMATION
    PALMER WILLIAM TAYLOR; Fiscal Year: 2013
    ..have spun off separate drug development endeavors directed novel nicotinic receptor ligands for depression, schizophrenia, pain alleviation and nicotine addiction and AChE inhibitor antidotes...
  19. Environmental regulation of estrogen dependent aggression
    Brian C Trainor; Fiscal Year: 2013
    ..Dysregulated aggression is a component of mental disorders including bipolar disorder, schizophrenia, and borderline personality disorder...
  20. Connexins in Neuronal and Glial Gap Junctions in the Central Nervous System
    John E Rash; Fiscal Year: 2012
    ..binding for learning and memory, and fine motor control, and which become pathologically altered in epilepsy, schizophrenia, Parkinson's disease, and autism spectral disorders...
  21. International Symposium on Proline Metabolism and Human Health
    Donald F Becker; Fiscal Year: 2010
    ..is recognized as having an important impact on bioenergetics, cellular redox control, apoptosis, cancer, schizophrenia, and connective tissue development...
  22. Zot, Zonulin, and Pathophysiology of Intestinal Tight Junctions
    Alessio Fasano; Fiscal Year: 2013
    ..more frequently encountered in immune-mediated conditions, including celiac disease, Crohn's disease, and schizophrenia, and its expression is associated with more severe clinical manifestations...
  23. Multiple Mechanisms of Nasal Chemoreception
    Diego Restrepo; Fiscal Year: 2012
    ..2005) and schizophrenia (Turetsky et al., 2003)...
  24. Derivation of cerebral cortical GABAergic interneurons from human iPS cells
    Lorenz P Studer; Fiscal Year: 2010
    ..of the cerebral cortex has been implicated in a variety of major neuropsychiatric illnesses, including schizophrenia, autism, anxiety, and epilepsy (where depression is a major source of morbidity)...
  25. Role of G-gamma-7 in striatal cannabinoid and D2 dopamine
    Dana E Selley; Fiscal Year: 2010
    ..help to determine molecular mechanisms contributing to neuropsychiatric disorders such as substance abuse and schizophrenia, as well as motor disorders...
  26. Functional Studies of Variants of the Bipolar Risk Gene CACNA1C in Human Neurons
    JEN PAN; Fiscal Year: 2013
    ..Interestingly, the same genomic region was found to be associated with schizophrenia and major depression susceptibility last year, making it one of the most replicable and consistent ..
  27. Presynaptic Mechanisms Regulating the Dopamine Transporter
    JAMES A HARDAWAY; Fiscal Year: 2013
    ..in DA signaling are associated with multiple neuropsychiatric and neurodegenerative disorders including schizophrenia, attention-deficit hyperactivity disorder (ADHD), and Parkinson's disease...
  28. Dissecting the role of one neuronal RhoGEF amongst many: the Kalirin-7 null mouse
    Richard E Mains; Fiscal Year: 2012
    ..In addition, Kalirin interacts with DISC1 (a candidate schizophrenia gene) and HAP1 (a Huntingtin interactor)...
  29. Modeling schizophrenia gamma deficits using cell-specific RNAi knockdown of GAD67
    RITCHIE EDWARD BROWN; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Understanding the cause of schizophrenia (Sz) is a major area of emphasis for NIMH...
  30. In utero programming of the dopamine system: behavior, neuroanatomy &epigenetics
    Teresa M Reyes; Fiscal Year: 2013
    ..g., attention deficit hyperactivity disorder (ADHD), addiction, schizophrenia)...
  31. Autoimmunity Against Novel Antigens in Neuropsychiatric Dysfunction
    Josep O Dalmau; Fiscal Year: 2013
    ..In 2007, we reported a group of young women who acutely developed psychotic behavior or schizophrenia-like symptoms, subsequently followed by memory defects, catatonia, abnormal movements, and autonomic ..
  32. Developmental Regulation of Brain and Behavior
    JULI S WADE; Fiscal Year: 2011
    ..of factors critical to normal development of brain morphology and behavior, and can lead to the discovery of solutions to problems, including those associated with mental health disorders such as autism, schizophrenia and depression.
  33. Cannabinoid regulation of glycogen synthase kinase-3
    Cecilia J Hillard; Fiscal Year: 2013
    ..Cannabis use, particularly by adolescents, increases the risk of developing schizophrenia-like psychoses in later life...
  34. CHOLINERGIC MECHANISMS OF REM SLEEP GENERATION
    Helen A Baghdoyan; Fiscal Year: 2013
    ..the cortical activation needed for attentional, learning, and memory functions of normal wakefulness, and schizophrenia and bipolar disorder are characterized by alterations in cortical activity and by sleep disruption...
  35. Development and Regulation of Cholinergic Synapses
    Andres Villu Maricq; Fiscal Year: 2013
    ..One receptor in particular, the homomeric a7 AChR, is associated with autism, anxiety and schizophrenia. The strength of a7-mediated neurotransmission is critically dependent on the localization and density of a7 ..
  36. Molecular mechanisms of bacterial homologs of neurotransmitter:sodium symporters
    Jonathan A Javitch; Fiscal Year: 2013
    ..drugs-as well as the transporters for GABA and glycine, which are targeted for treatment of epilepsy and schizophrenia. In 2005 the Gouaux group solved at 1...
  37. Phospholemman and Cardiac Contracility
    Joseph Y Cheung; Fiscal Year: 2013
    ..in phospholemman expression or its phosphorylation state are observed in ischemic cardiomyopathy and schizophrenia. In addition, the 2 classes of drugs (b-blockers and ACE inhibitors) that have been clinically found to be ..
  38. Synaptic autoimmunity in disorders of memory, behavior, cognition and psychosis
    Josep Dalmau; Fiscal Year: 2010
    ..In 2007, we first reported a group of young women who acutely developed psychotic behavior or schizophrenia, subsequently followed by decrease of memory, catatonia, abnormal movements, and autonomic dysfunction...
  39. Subunit dependent properties of kainate receptors
    David D Mott; Fiscal Year: 2013
    ..receptors have also been implicated in a number of neurological disorders including temporal lobe epilepsy, schizophrenia, autism, and neuropathic pain...
  40. MOLECULAR PROPERTIES OF IONIC PERMEABILITY IN NERVE
    Bertil Hille; Fiscal Year: 2013
    ..When such ubiquitous signaling goes wrong either in neurodegenerative diseases, schizophrenia, Parkinsonism, or depression, or by action of drugs of abuse, there are major alterations in states of mind, ..
  41. GABA chaperoning of epilepsy-associated GABAA receptor mutants.
    Nancy J Leidenheimer; Fiscal Year: 2012
    ..The GABAA receptor is associated with a variety of neurological (epilepsy, insomnia) and psychiatric (anxiety, schizophrenia) disorders (Mohler, 2006;Charych et al...
  42. Understanding the Role of COMT Variants in Sensorimotor Gating
    XIANJIN ZHOU; Fiscal Year: 2010
    ..Since evidence supports a reduction in dopamine signaling in prefrontal cortex in schizophrenia patients, the relationship between the COMT gene and schizophrenia has been extensively studied...
  43. Basal Forebrain Cellular Mechanisms of Cortical Activation
    Robert W McCarley; Fiscal Year: 2013
    ..oscillations in three different cortical regions affected by sleep deprivation and exhibiting abnormalities in schizophrenia. In addition, Fos immunohistochemistry will be used to provide a spatial and cell-type specific analysis of ..
  44. ULTRASTRUCTURE OF MESOLIMBIC TRANSMITTER INTERACTIONS
    Virginia M Pickel; Fiscal Year: 2012
    ..will provide information that is essential for understanding and developing new strategies for treating schizophrenia and possibly other psychiatric disorders...
  45. microRNA analysis of neurons generated from patient-specific iPSCs
    Herbert M Lachman; Fiscal Year: 2013
    ..findings have emerged in studying gene expression profiling in autopsy samples obtained from subjects with schizophrenia (SZ), there are numerous confounding factors that could affect data interpretation including co- morbid ..
  46. Epigenome Mapping in Cortical Interneurons
    Schahram Akbarian; Fiscal Year: 2013
    ..histone methylation mapping of specific interneuron types is likely to provide radically novel insights into the developmental history and (epi)genomic architecture of cells ascribed a key role in schizophrenia and related disease.
  47. How do Amine Neurons Work?
    Edward A Kravitz; Fiscal Year: 2013
    ..in which subsets of the dopamine neurons selectively die, and psychiatric disorders including mood disorders, schizophrenia, attention-deficit hyperactivity disorder and drug abuse in which the amines dopamine, serotonin and ..
  48. Regulation of 22q11 Genes in Embroyonic and Adult Forebrain
    Anthony S LaMantia; Fiscal Year: 2013
    ..language and social cognition deficits, attention deficit/hyperactivity disorder, autism, mood disorders, and schizophrenia. There is general consensus that these disorders reflect compromised development or maintenance of cortical ..
  49. NHERF-1 and dopamine-mediated regulation of renal phosphate transport.
    Edward J Weinman; Fiscal Year: 2013
    ..of the role of NHERF-1 in other physiologic and pathophysiologic processes such as nephrolithiasis, schizophrenia, psoriasis, aggressive forms of estrogen receptor positive breast cancer, and nerve deafness (Usher's ..
  50. Identifying Biomarkers for Post-Partum Depression in African-American Women
    Patrick F Sullivan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In contrast to progress for autism, bipolar disorder, and schizophrenia, discerning the biological basis of major depressive disorder (MDD) has been difficult...
  51. MRDD Research Center
    KARL PFENNINGER; Fiscal Year: 2009
    ..disorders: autism, Down syndrome, fragile X syndrome, dyslexia, attention deficit hyperactivity disorder, and schizophrenia. A third group seeks to understand the phenotype and core deficits in very young children with autism and the ..
  52. Disruption of Extracellular Matrix-Glial Interactions in Schizophrenia
    Sabina Berretta; Fiscal Year: 2013
    ..point to substantial abnormalities affecting CSPGs in the amygdala and entorhinal cortex of subjects with schizophrenia, but not bipolar disorder...
  53. CRCNS: Gamma Rhythms and Cell Assemblies
    Nancy Kopell; Fiscal Year: 2013
    ..Mental illnesses, notably schizophrenia, are associated with pathologies in this rhythm, and many people are now studying these pathologies for clues ..
  54. Thyroid hormone-dependent DNA methylation in the developing brain
    Yasuhiro Kyono; Fiscal Year: 2012
    ..Such understanding can contribute to the prevention, diagnosis and treatment of human neurological conditions such as mental retardation, autism spectrum disorder and schizophrenia.
  55. Structural determinants of DTI observations in developing cortex and white matter
    Christopher D Kroenke; Fiscal Year: 2013
    ..g. fetal alcohol spectrum disorder, premature birth), or multifactorial (e.g. autism, schizophrenia) origin...
  56. CRCNS: Theory and experiment of neural circuit mapping by DNA sequencing
    Anthony M Zador; Fiscal Year: 2013
    ..Many neuropsychiatric and neurodegenerative disorders, including schizophrenia, autism spectrum disorders, Alzheimer's and Parkinson's diseases, are linked to abnormal changes in ..
  57. Molecular-Genetic Dissection of Basal Forebrain Circuitry Regulating Arousal
    PATRICK MICHAEL FULLER; Fiscal Year: 2013
    ..neuropsychiatric and neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease, schizophrenia and the cognitive impairments of normal aging...
  58. DETERMINATION OF NEURONAL FATES IN VISUAL CORTEX
    Susan K McConnell; Fiscal Year: 2013
    ..and connectivity of cortical neurons are associated with a variety of disorders including epilepsy, dyslexia, schizophrenia, bipolar affective illness, and autism...
  59. miR132 regulation of neuronal plasticity, learning, and memory
    KATELIN L F HANSEN; Fiscal Year: 2013
    ..Altered miR132 is associated with several psychiatric (schizophrenia) and degenerative (Huntington's disease) disorders of the nervous system...
  60. Molecular and cellular mechanism of Microcephaly
    Arnold Kriegstein; Fiscal Year: 2013
    ..but also to advance our understanding and potential treatment of a variety of other neurodevelopmental disorders caused through defects in cerebral cortex development including mental retardation, epilepsy, autism, and schizophrenia.
  61. Nicotinic receptor stimulation and epigenetic regulation of GABAergic function.
    Alessandro Guidotti; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Treatment of schizophrenia (SZ) patients with monoaminergic antagonist drugs (typical or atypical neuroleptics) has an antipsychotic effect, but negative symptoms and cognition are not significantly ..
  62. Aptamer probes for Epigenetic Peptide Targets
    MARK PATRICK MCPIKE; Fiscal Year: 2010
    ..For example, mental health diseases such as bipolar disorder and schizophrenia are associated with epigenetic changes in the promoters of enzymes that metabolize neurotransmitters...
  63. Cell Communication of the Vertebrate Retina
    ROBERT FRANCIS MILLER; Fiscal Year: 2012
    ..A second health-related matter of importance comes from the modern treatment of schizophrenia, where thousands of patients are being treated with high doses of oral D-serine to activate NMDA receptors ..
  64. Signal transduction in TRPM5-expressing olfactory sensory neurons
    Diego Restrepo; Fiscal Year: 2010
    ..The qualifying grant of this FIRCA application is an NIMH-funded Conte Center grant focused on the study of schizophrenia (see Specific Aims)...
  65. Targeting of alpha7 nAChR for therapeutic effects
    Roger L Papke; Fiscal Year: 2013
    ..the cause of addiction is the alpha7-type receptor, and stimulation of this receptor combats conditions like schizophrenia, Alzheimer's disease, septic shock and other inflammatory diseases...
  66. Unconventional Synaptic Modulation at the Vertebrate Neuromuscular Junction
    Clark A Lindgren; Fiscal Year: 2010
    ..NAAG has been implicated in numerous pathologies including pain, traumatic brain injury, schizophrenia and stroke...
  67. Prodrugs of NAAG Peptidase Inhibitors for the Treatment of Schizophrenia
    Jia Zhou; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Schizophrenia is a chronic, severe, and disabling brain disease...
  68. GENE EXPRESSION EXON ARRAY BIOMARKERS TO DIAGNOSE SCHIZOPHRENIA
    Terry W Osborn; Fiscal Year: 2010
    ..by applicant): AbaStar MDx RFA-OD-09-009, (R43), SBIR - Gene Expression Exon Array Biomarkers to Diagnose Schizophrenia Project Summary/Abstract This application RFA-OD-09-009, addresses Recovery Act Limited Competition: Small ..
  69. Using fMRI to Measure Negative Symptoms in Schizophrenia
    EDWARD E contact SMITH; Fiscal Year: 2010
    ..b>Schizophrenia, a devastating psychiatric disorder, is chiefly characterized by positive symptoms, such as delusions and ..
  70. Remediation of Working Memory in Schizophrenia
    Tasha Nienow; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Schizophrenia is among the most disabling illnesses of adults in the world...
  71. Brain-Based Measures for Treatment Development of Impaired Cognition in Schizophr
    Cameron S Carter; Fiscal Year: 2010
    ..there has been a growing awareness of the disabling and treatment refractory effects of impaired cognition in schizophrenia, which results in performance deficits that are strongly and consistently related to poor functional outcome ..
  72. Genetic markers of white matter integrity in schizophrenia: Relationship to clini
    Vince D Calhoun; Fiscal Year: 2010
    ..of genetic and neuroimaging tools to identify novel biomarkers of clinical severity in patients with schizophrenia. Schizophrenia is a chronic and severely debilitating mental disorder affecting approximately 1% of the world&..
  73. In vivo methods for preclinical analysis of cognitive therapies for schizophrenia
    JONATHAN MAX LEVENSON; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Schizophrenia is a devastating mental illness that affects approximately 1% of the global population...
  74. Epigenetic Markings in Developing and Diseased Prefrontal Neurons
    Schahram Akbarian; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Schizophrenia is defined by a lack of a straightforward genetic cause for a very large majority of affected individuals...
  75. Microstructural Characterization of White Matter in Schizophrenia
    Mariana Lazar; Fiscal Year: 2010
    b>Schizophrenia is a chronic, severe, and disabling disorder that is characterized by hallucinations, delusions, and motor deficits...
  76. Plasticity-Based Adaptive Cognitive Remediation for Schizophrenia
    HENRY WILTSHIRE MAHNCKE; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): People with schizophrenia have significant challenges functioning in society, including finding and maintaining employment, making friends, and living independently...
  77. EPILEPSY AS A NEUROLOGICAL MODEL OF SCHIZOPHRENIA
    Laura Marsh; Fiscal Year: 2000
    DESCRIPTION (Adapted from applicant's abstract): Neuroanatomical abnormalities reported in schizophrenia include evidence for focal dysmorphology as well as global nonspecific neuropathology...
  78. Mechanisms of schizophrenia-like phenotypes in BACE 1 knockout mice
    Alena Savonenko; Fiscal Year: 2010
    ..Because NRG1 has also been genetically linked to schizophrenia, we tested whether BACE1-/- mice with impaired processing of NRG1 show schizophrenia-like behavioral ..
  79. Imaging dopamine transmission in comorbid schizophrenia and cannabis dependence
    Anissa Abi Dargham; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Dopamine (DA) plays a role in the pathophysiology of schizophrenia and addiction...
  80. STN/Three Individual Projects: COATS, METS, CRSTN
    Scott Stroup; Fiscal Year: 2009
    COATS: Comparison of Optimal Antipsychotic Treatments for Schizophrenia Abstract: Using innovative, preemptive approaches to prevent and manage adverse effects, this study compares aripiprazole, perphenazine, and olanzapine in the ..
  81. DNA EXPANSION IN SCHIZOPHRENIA
    Cynthia McMurray; Fiscal Year: 2000
    DESCRIPTION (Adapted from applicant's abstract): Schizophrenia is a severe disorder characterized by psychotic symptoms such as delusions and hallucinations and/or debilitating behavioral symptoms...
  82. Paternal Age Related Schizophrenia as a Discrete Disorder
    Dolores Malaspina; Fiscal Year: 2010
    ..We propose an innovative study aimed at refining and validating a clinical phenotype for "paternal age related schizophrenia" (PARS)...
  83. First Episode Psychosis in South India
    Ashok Malla; Fiscal Year: 2009
    One of the most consistent findings in both cultural psychiatry and outcome research in schizophrenia is that outcomes of schizophrenia are better in developing countries than in developed ones...
  84. Mechanism-based, pro-cognitive therapies for schizophrenia
    DAVID JULIAN GERBER; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Schizophrenia is a debilitating psychiatric disorder that affects about 0.7% of the global population...
  85. Mice Harboring Human DISC1-Boymaw Fusion Transcripts
    XIANJIN ZHOU; Fiscal Year: 2010
    b>Schizophrenia is a common disease in the general population with 1% prevalence...
  86. An EEG Study of Neural Dynamics in Schizophrenia
    Kevin Spencer; Fiscal Year: 2006
    ..neural synchrony in the electroencephalogram (EEG) to examine the functional integrity of neural circuitry in schizophrenia. Schizophrenia has been conceptualized as a failure of cognitive integration, and abnormalities in neural ..