psychotic disorders

Summary

Summary: Disorders in which there is a loss of ego boundaries or a gross impairment in reality testing with delusions or prominent hallucinations. (From DSM-IV, 1994)

Top Publications

  1. ncbi A systematic review and meta-analysis of the psychosis continuum: evidence for a psychosis proneness-persistence-impairment model of psychotic disorder
    J van Os
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Psychol Med 39:179-95. 2009
  2. pmc Childhood adversities increase the risk of psychosis: a meta-analysis of patient-control, prospective- and cross-sectional cohort studies
    Filippo Varese
    Institute of Psychology, Health and Society University of Liverpool, UK
    Schizophr Bull 38:661-71. 2012
  3. pmc Long-term antipsychotic treatment and brain volumes: a longitudinal study of first-episode schizophrenia
    Beng Choon Ho
    Departments of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Arch Gen Psychiatry 68:128-37. 2011
  4. pmc A review of MRI findings in schizophrenia
    M E Shenton
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Harvard Medical School, Brockton, MA 02301, USA
    Schizophr Res 49:1-52. 2001
  5. ncbi Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review
    Theresa H M Moore
    Academic Unit of Psychiatry, University of Bristol, Bristol, UK
    Lancet 370:319-28. 2007
  6. ncbi Cognitive functioning in prodromal psychosis: a meta-analysis
    Paolo Fusar-Poli
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, England, UK
    Arch Gen Psychiatry 69:562-71. 2012
  7. ncbi Children's self-reported psychotic symptoms and adult schizophreniform disorder: a 15-year longitudinal study
    R Poulton
    Dunedin Multidisciplinary Health and Development Research Unit, Dunedin School of Medicine, University of Otago, PO Box 913, Dunedin, New Zealand
    Arch Gen Psychiatry 57:1053-8. 2000
  8. ncbi Long-chain omega-3 fatty acids for indicated prevention of psychotic disorders: a randomized, placebo-controlled trial
    G Paul Amminger
    Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria
    Arch Gen Psychiatry 67:146-54. 2010
  9. ncbi Mapping the onset of psychosis: the Comprehensive Assessment of At-Risk Mental States
    Alison R Yung
    Department of Psychiatry, University of Melbourne, Melbourne, Australia
    Aust N Z J Psychiatry 39:964-71. 2005
  10. ncbi Prediction of psychosis by mismatch negativity
    Mitja Bodatsch
    Department of Psychiatry and Psychotherapy, University of Cologne, Germany
    Biol Psychiatry 69:959-66. 2011

Detail Information

Publications296 found, 100 shown here

  1. ncbi A systematic review and meta-analysis of the psychosis continuum: evidence for a psychosis proneness-persistence-impairment model of psychotic disorder
    J van Os
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Psychol Med 39:179-95. 2009
    ....
  2. pmc Childhood adversities increase the risk of psychosis: a meta-analysis of patient-control, prospective- and cross-sectional cohort studies
    Filippo Varese
    Institute of Psychology, Health and Society University of Liverpool, UK
    Schizophr Bull 38:661-71. 2012
    ..75 [95% CI = 2.17-3.47]). The estimated population attributable risk was 33% (16%-47%). These findings indicate that childhood adversity is strongly associated with increased risk for psychosis...
  3. pmc Long-term antipsychotic treatment and brain volumes: a longitudinal study of first-episode schizophrenia
    Beng Choon Ho
    Departments of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Arch Gen Psychiatry 68:128-37. 2011
    ..Because antipsychotics are prescribed for long periods for schizophrenia patients and have increasingly widespread use in other psychiatric disorders, it is imperative to determine their long-term effects on the human brain...
  4. pmc A review of MRI findings in schizophrenia
    M E Shenton
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Harvard Medical School, Brockton, MA 02301, USA
    Schizophr Res 49:1-52. 2001
    ..abstract truncated)..
  5. ncbi Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review
    Theresa H M Moore
    Academic Unit of Psychiatry, University of Bristol, Bristol, UK
    Lancet 370:319-28. 2007
    ..We systematically reviewed the evidence pertaining to cannabis use and occurrence of psychotic or affective mental health outcomes...
  6. ncbi Cognitive functioning in prodromal psychosis: a meta-analysis
    Paolo Fusar-Poli
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, England, UK
    Arch Gen Psychiatry 69:562-71. 2012
    ..Cognitive deficits may predate the onset of psychosis and may be useful as markers of increased vulnerability to illness...
  7. ncbi Children's self-reported psychotic symptoms and adult schizophreniform disorder: a 15-year longitudinal study
    R Poulton
    Dunedin Multidisciplinary Health and Development Research Unit, Dunedin School of Medicine, University of Otago, PO Box 913, Dunedin, New Zealand
    Arch Gen Psychiatry 57:1053-8. 2000
    ..We report the first direct examination of the longitudinal relationship between psychotic symptoms in childhood and adulthood...
  8. ncbi Long-chain omega-3 fatty acids for indicated prevention of psychotic disorders: a randomized, placebo-controlled trial
    G Paul Amminger
    Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria
    Arch Gen Psychiatry 67:146-54. 2010
    The use of antipsychotic medication for the prevention of psychotic disorders is controversial...
  9. ncbi Mapping the onset of psychosis: the Comprehensive Assessment of At-Risk Mental States
    Alison R Yung
    Department of Psychiatry, University of Melbourne, Melbourne, Australia
    Aust N Z J Psychiatry 39:964-71. 2005
    ..This paper describes the pilot evaluation of the CAARMS...
  10. ncbi Prediction of psychosis by mismatch negativity
    Mitja Bodatsch
    Department of Psychiatry and Psychotherapy, University of Cologne, Germany
    Biol Psychiatry 69:959-66. 2011
    ..To this aim, mismatch negativity (MMN) was investigated in a sample clinically at high risk, comparing individuals with and without subsequent conversion to psychosis...
  11. ncbi Prediction of psychosis in adolescents and young adults at high risk: results from the prospective European prediction of psychosis study
    Stephan Ruhrmann
    Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany
    Arch Gen Psychiatry 67:241-51. 2010
    ..Existing criteria need improvement in terms of specificity and individual risk assessment to allow for better targeted and earlier interventions...
  12. ncbi Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review
    John W Newcomer
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    CNS Drugs 19:1-93. 2005
    ....
  13. ncbi Predicting psychosis: meta-analysis of transition outcomes in individuals at high clinical risk
    Paolo Fusar-Poli
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, United Kingdom
    Arch Gen Psychiatry 69:220-9. 2012
    ..However, the risk of transition to psychosis varies between centers, and some recent work suggests that the risk of transition may be declining...
  14. ncbi Emotional reactivity to daily life stress in psychosis
    I Myin-Germeys
    Department of Psychiatry and Neuropsychology, European Graduate School of Neuroscience, Maastricht University, Maastricht, The Netherlands
    Arch Gen Psychiatry 58:1137-44. 2001
    BACKGROUND: The vulnerability-stress model of psychotic disorders describes, in essence, an interaction between personal vulnerability and environmental stressors...
  15. ncbi Efficacy of using cognitive status in predicting psychosis: a 7-year follow-up
    Anita Riecher-Rössler
    Psychiatric Outpatient Department, University Hospital, Basel, Switzerland
    Biol Psychiatry 66:1023-30. 2009
    ..We therefore investigated long-term psychosis transition in individuals with an At Risk Mental State (ARMS) and examined the relative efficacy of clinical and neuropsychological status in optimizing the prediction of transition...
  16. ncbi The cognitive and affective structure of paranoid delusions: a transdiagnostic investigation of patients with schizophrenia spectrum disorders and depression
    Richard P Bentall
    School of Psychology, Adeilad Brigantia Bldg, Penrallt Road, Gwynedd, Wales
    Arch Gen Psychiatry 66:236-47. 2009
    Paranoid delusions are a common symptom of a range of psychotic disorders. A variety of psychological mechanisms have been implicated in their cause, including a tendency to jump to conclusions, an impairment in the ability to understand ..
  17. pmc Evidence that psychotic symptoms are prevalent in disorders of anxiety and depression, impacting on illness onset, risk, and severity--implications for diagnosis and ultra-high risk research
    Johanna T W Wigman
    Department of Interdisciplinary Social Science, University of Utrecht, 3508 TC Utrecht, The Netherlands
    Schizophr Bull 38:247-57. 2012
    ..It is commonly assumed that there are clear lines of demarcation between anxiety and depressive disorders on the one hand and psychosis on the other. Recent evidence, however, suggests that this principle may be in need of updating...
  18. pmc Are screening instruments valid for psychotic-like experiences? A validation study of screening questions for psychotic-like experiences using in-depth clinical interview
    Ian Kelleher
    Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
    Schizophr Bull 37:362-9. 2011
    ..Our results suggest that it may be possible to screen the general adolescent population for psychotic-like experiences with a high degree of accuracy using a short self-report questionnaire...
  19. ncbi Real-time electronic ambulatory monitoring of substance use and symptom expression in schizophrenia
    Joel Swendsen
    National Center for Scientific Research, CNRS UMR, Bordeaux, France
    Am J Psychiatry 168:202-9. 2011
    ..The authors used electronic personal digital assistants (PDAs) to examine the temporal association of diverse forms of substance use with psychotic symptoms and psychological states in natural contexts...
  20. ncbi Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: a systematic review
    Max Marshall
    Division of Psychiatry, University of Manchester, Manchester
    Arch Gen Psychiatry 62:975-83. 2005
    ..It has been postulated that a longer DUP leads to a poorer prognosis. If so, outcome might be improved through earlier detection and treatment...
  21. pmc Etiological and clinical features of childhood psychotic symptoms: results from a birth cohort
    Guilherme Polanczyk
    Department of Psychology and Neuroscience, Duke University, 2020 W Main St, Ste 201, Campus Box 104410, Durham, NC 27708, USA
    Arch Gen Psychiatry 67:328-38. 2010
    ..However, it is not clear whether these symptoms are associated with the same extensive risk factors established for adult schizophrenia...
  22. ncbi Stress-reactivity in psychosis: evidence for an affective pathway to psychosis
    Inez Myin-Germeys
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Clin Psychol Rev 27:409-24. 2007
    ..These findings are discussed in the light of recent biological and psychological mechanisms...
  23. pmc Evidence that onset of clinical psychosis is an outcome of progressively more persistent subclinical psychotic experiences: an 8-year cohort study
    M D G Dominguez
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University Medical Centre, PO BOX 616 DRT 10, 6200 MD Maastricht, The Netherlands
    Schizophr Bull 37:84-93. 2011
    ..This may be summarized descriptively as a psychosis proneness-persistence-impairment model of psychotic disorder...
  24. ncbi Predictors of relapse following response from a first episode of schizophrenia or schizoaffective disorder
    D Robinson
    Department of Psychiatry, Hillside Hospital, Long Island Jewish Medical Center, Glen Oaks, NY 11004, USA
    Arch Gen Psychiatry 56:241-7. 1999
    ..We examined relapse after response to a first episode of schizophrenia or schizoaffective disorder...
  25. ncbi Childhood trauma, psychosis and schizophrenia: a literature review with theoretical and clinical implications
    J Read
    Department of Psychology, The University of Auckland, Auckland, New Zealand
    Acta Psychiatr Scand 112:330-50. 2005
    ..To review the research addressing the relationship of childhood trauma to psychosis and schizophrenia, and to discuss the theoretical and clinical implications...
  26. ncbi Antipsychotic-induced weight gain: a comprehensive research synthesis
    D B Allison
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, NY 10025, UDA
    Am J Psychiatry 156:1686-96. 1999
    ..The purpose of this study was to estimate and compare the effects of antipsychotics-both the newer ones and the conventional ones-on body weight...
  27. ncbi Neuroanatomy of vulnerability to psychosis: a voxel-based meta-analysis
    P Fusar-Poli
    University Psychiatric Unit, Brescia University School of Medicine and Brescia Spedali Civili, Brescia, Italy
    Neurosci Biobehav Rev 35:1175-85. 2011
    ....
  28. ncbi Psychotic experiences and psychotic disorders at age 18 in relation to psychotic experiences at age 12 in a longitudinal population-based cohort study
    Stanley Zammit
    MRC Center for Neuropsychiatric Genetics and Genomics, Cardiff University, UK
    Am J Psychiatry 170:742-50. 2013
    OBJECTIVE The authors examined the development of psychotic experiences and psychotic disorders in a large population-based sample of young adults and explored their relationship to psychotic phenomena earlier in childhood...
  29. ncbi Duration mismatch negativity and P3a in first-episode psychosis and individuals at ultra-high risk of psychosis
    Rebbekah J Atkinson
    Priority Centre for Brain and Mental Health Research, University of Newcastle, Newcastle, Australia
    Biol Psychiatry 71:98-104. 2012
    ....
  30. ncbi Body composition in psychotic disorders: a general population survey
    S E Saarni
    National Public Health Institute, Department for Mental Health and Alcohol Research, Mannerheimintie 166, 00300 Helsinki, Finland
    Psychol Med 39:801-10. 2009
    ..than only waist circumference and obesity [body mass index (BMI) 30 kg/m2], have not been reported in psychotic disorders. We examined the detailed body composition of people with different psychotic disorders in a large ..
  31. ncbi Size of burden of schizophrenia and psychotic disorders
    Wulf Rossler
    Psychiatric University Hospital, Militarstrasse 8, CH 8021 Zurich, Switzerland
    Eur Neuropsychopharmacol 15:399-409. 2005
    ....
  32. ncbi Heterogeneity in incidence rates of schizophrenia and other psychotic syndromes: findings from the 3-center AeSOP study
    James B Kirkbride
    Department of Psychiatry, University of Cambridge, Cambridge, England
    Arch Gen Psychiatry 63:250-8. 2006
    ..Convention suggests uniformity of incidence of schizophrenia and other psychoses; variation would have implications for their causes and biological characteristics...
  33. pmc Use of neuroanatomical pattern classification to identify subjects in at-risk mental states of psychosis and predict disease transition
    Nikolaos Koutsouleris
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Arch Gen Psychiatry 66:700-12. 2009
    ..Recently, machine learning algorithms have been successfully used for magnetic resonance imaging-based diagnostic classification of neuropsychiatric patient populations...
  34. ncbi Social adversity in childhood and the risk of developing psychosis: a national cohort study
    Susanne Wicks
    Unit of Epidemiology, Stockholm Centre for Public Health, Norrbacka, Floor 5, 171 76 Stockholm, Sweden
    Am J Psychiatry 162:1652-7. 2005
    ..Previous studies have had inadequate designs. The aim of the present study was to describe a broad range of social factors during childhood and the risk of developing psychosis later in life in a national cohort...
  35. ncbi Cognitive--behavioural therapy and family intervention for relapse prevention and symptom reduction in psychosis: randomised controlled trial
    Philippa A Garety
    Department of Psychology, PO77, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
    Br J Psychiatry 192:412-23. 2008
    ..Family intervention reduces relapse rates in psychosis. Cognitive-behavioural therapy (CBT) improves positive symptoms but effects on relapse rates are not established...
  36. ncbi Community screening for psychotic-like experiences and other putative antecedents of schizophrenia in children aged 9-12 years
    Kristin R Laurens
    Department of Forensic Mental Health Science, Institute of Psychiatry, King s College London, Box P023, De Crespigny Park, London SE5 8AF, UK
    Schizophr Res 90:130-46. 2007
    ..The results suggest that questionnaire screening of community samples of children for the putative antecedents of schizophrenia spectrum disorders is feasible. Accuracy of identification will only be established by follow-up studies...
  37. ncbi Neuroimaging predictors of transition to psychosis--a systematic review and meta-analysis
    R Smieskova
    Psychiatric Outpatient Department, Psychiatric University Clinics, Basel, Switzerland
    Neurosci Biobehav Rev 34:1207-22. 2010
    ..In early stage psychosis research the identification of neurobiological correlates of vulnerability to schizophrenia is an important hurdle...
  38. ncbi Neurofunctional correlates of vulnerability to psychosis: a systematic review and meta-analysis
    Paolo Fusar-Poli
    Department of Applied and Psychobehavioural Health Sciences, University of Pavia, Italy
    Neurosci Biobehav Rev 31:465-84. 2007
    ..These abnormalities have mainly been described in the prefrontal and anterior cingulated cortex, the basal ganglia, hippocampus and cerebellum...
  39. ncbi Cardiovascular disease and diabetes in people with severe mental illness position statement from the European Psychiatric Association (EPA), supported by the European Association for the Study of Diabetes (EASD) and the European Society of Cardiology (ESC
    M De Hert
    University Psychiatric, Centre Catholic University, Leuven campus Kortenberg, Leuvensesteenweg 517, 3070 Kortenberg, Belgium
    Eur Psychiatry 24:412-24. 2009
    ....
  40. ncbi Reasoning, emotions, and delusional conviction in psychosis
    Philippa A Garety
    Department of Psychology, Institute of Psychiatry, King s College London, London, England
    J Abnorm Psychol 114:373-84. 2005
    ..Emotional states were not associated with the reasoning processes investigated. Anxiety, but not depression, made an independent contribution to delusional conviction...
  41. ncbi Heritability estimates for psychotic disorders: the Maudsley twin psychosis series
    A G Cardno
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Arch Gen Psychiatry 56:162-8. 1999
    Previous twin studies have supported a genetic contribution to the major categories of psychotic disorders, but few of these have employed operational diagnostic criteria, and no such study has been based on a sample that included the ..
  42. pmc Large recurrent microdeletions associated with schizophrenia
    Hreinn Stefansson
    CNS Division, deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
    Nature 455:232-6. 2008
    ..CNV analysis may also point the way to the identification of additional and more prevalent risk variants in genes and pathways involved in schizophrenia...
  43. ncbi Suspicious minds: the psychology of persecutory delusions
    Daniel Freeman
    Department of Psychology, Institute of Psychiatry, King s College London, Denmark Hill, London, UK
    Clin Psychol Rev 27:425-57. 2007
    ..Ten key future research questions are identified, including the need for researchers to consider factors important to the different dimensions of delusional experience...
  44. ncbi Psychosis prediction: 12-month follow up of a high-risk ("prodromal") group
    Alison R Yung
    Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia
    Schizophr Res 60:21-32. 2003
    ..The findings support the development of more specific preventive strategies targeting the prodromal phase for some individuals at ultra high risk of schizophrenia...
  45. ncbi Neuroanatomical abnormalities that predate the onset of psychosis: a multicenter study
    Andrea Mechelli
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, United Kingdom
    Arch Gen Psychiatry 68:489-95. 2011
    ..However, the samples examined to date have been small, and the findings have been inconsistent...
  46. ncbi The incidence and outcome of subclinical psychotic experiences in the general population
    Manon Hanssen
    Department of Psychiatry and Neuropsychology, Universiteit Maastricht, The Netherlands
    Br J Clin Psychol 44:181-91. 2005
    ..To examine the incidence and 2-year stability and outcome of subclinical psychotic experiences in the general population...
  47. pmc Neuropsychological profiles in different at-risk states of psychosis: executive control impairment in the early--and additional memory dysfunction in the late--prodromal state
    Ingo Frommann
    Department of Psychiatry, University Hospital of Bonn, Sigmund Freud Street 25, Bonn, Germany
    Schizophr Bull 37:861-73. 2011
    ..Memory deficits were associated with the onset of psychotic symptoms indicating further disease progression in the trajectory to psychosis and, thus, may be useful in predicting psychosis and targeting early intervention...
  48. ncbi Intervention in individuals at ultra-high risk for psychosis: a review and future directions
    Patrick D McGorry
    Centre for Youth Mental Health, Orygen Youth Health Research Centre, University of Melbourne, Victoria, Australia
    J Clin Psychiatry 70:1206-12. 2009
    Over the last 15 years, a focus on early intervention in psychotic disorders has emerged. Initially, the early psychosis movement focused on timely recognition and phase-specific treatment of first-episode psychosis...
  49. ncbi Evidence that three dimensions of psychosis have a distribution in the general population
    N C Stefanis
    University Mental Health Research Institute UMHRI, Athens, Greece
    Psychol Med 32:347-58. 2002
    ....
  50. ncbi Effects of cannabis use on outcomes of psychotic disorders: systematic review
    Stanley Zammit
    Academic Unit of Psychiatry, University of Bristol, UK
    Br J Psychiatry 193:357-63. 2008
    ..It is unclear if research findings support clinical opinion that cannabis use leads to worse outcomes in people with psychosis, or whether this impression is confounded by other factors...
  51. ncbi Bipolar disorder, schizophrenia, and other psychotic disorders in adults with childhood onset AD/HD and/or autism spectrum disorders
    O Stahlberg
    Department of Child and Adolescent Psychiatry, Goteborg University, Sweden
    J Neural Transm 111:891-902. 2004
    ..In this study, we describe the prevalence and patterns of comorbid bipolar and psychotic disorders in 241 consecutively referred adult patients with AD/HD and/or ASD...
  52. pmc Examining a cognitive model of persecutory ideation in the daily life of people with schizophrenia: a computerized experience sampling study
    Dror Ben-Zeev
    Illinois Institute of Technology, Chicago, IL 60616, USA
    Schizophr Bull 37:1248-56. 2011
    ....
  53. pmc Identification of a serotonin/glutamate receptor complex implicated in psychosis
    Javier Gonzalez-Maeso
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nature 452:93-7. 2008
    ..These regulatory changes indicate that the 2AR-mGluR2 complex may be involved in the altered cortical processes of schizophrenia, and this complex is therefore a promising new target for the treatment of psychosis...
  54. ncbi Individuals, schools, and neighborhood: a multilevel longitudinal study of variation in incidence of psychotic disorders
    Stanley Zammit
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, Cardiff University, Wales, UK
    Arch Gen Psychiatry 67:914-22. 2010
    ..Few studies have examined whether both individual and neighborhood characteristics can explain this association. Furthermore, as has been shown for ethnicity, the effect of individual characteristics may depend on neighborhood context...
  55. ncbi Frontal responses during learning predict vulnerability to the psychotogenic effects of ketamine: linking cognition, brain activity, and psychosis
    Philip R Corlett
    Brain Mapping Unit, Department of Psychiatry, School of Clinical Medicine, University of Cambridge, Cambridge, England
    Arch Gen Psychiatry 63:611-21. 2006
    ..Establishing a neurobiological account of delusion formation that links cognitive processes, brain activity, and symptoms is important to furthering our understanding of psychosis...
  56. ncbi Do antipsychotic drugs affect brain structure? A systematic and critical review of MRI findings
    S Navari
    Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, UK
    Psychol Med 39:1763-77. 2009
    ..This review addresses two issues: (1) do antipsychotic medications induce changes in total or regional human brain volumes and (2) do such effects depend on antipsychotic type?..
  57. ncbi Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction
    Avshalom Caspi
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Biol Psychiatry 57:1117-27. 2005
    ..The vast majority of cannabis users do not develop psychosis, however, prompting us to hypothesize that some people are genetically vulnerable to the deleterious effects of cannabis...
  58. pmc Feasibility and validity of computerized ecological momentary assessment in schizophrenia
    Eric Granholm
    Psychology Service, VA San Diego Healthcare System 116B, San Diego, CA 92161, USA
    Schizophr Bull 34:507-14. 2008
    ..The present investigation examined the feasibility and validity of this assessment methodology in outpatients with schizophrenia...
  59. ncbi Implications for neurobiological research of cognitive models of psychosis: a theoretical paper
    Philippa A Garety
    Department of Psychology, Institute of Psychiatry, King s College London, London, UK
    Psychol Med 37:1377-91. 2007
    ....
  60. pmc Major self-mutilation in the first episode of psychosis
    Matthew Large
    Schizophr Bull 35:1012-21. 2009
    ..Acute psychosis, in particular first-episode schizophrenia, appears to be the major cause of MSM. Although MSM is extremely uncommon, earlier treatment of psychotic illness may reduce the incidence of MSM...
  61. ncbi Raised incidence rates of all psychoses among migrant groups: findings from the East London first episode psychosis study
    Jeremy W Coid
    Forensic Psychiatry Research Unit, St Bartholomew s Hospital, William Harvey House, 61 Bartholomew Close, London EC1A7BE, England
    Arch Gen Psychiatry 65:1250-8. 2008
    ..It is unknown whether risk for second- and later-generation black and minority ethnic groups in the United Kingdom is universally increased or varies by ethnicity, population structure, or diagnostic category...
  62. pmc Childhood trauma and children's emerging psychotic symptoms: A genetically sensitive longitudinal cohort study
    Louise Arseneault
    Medical Research Council Social, Genetic, and Developmental Psychiatry Centre, King s College London, UK
    Am J Psychiatry 168:65-72. 2011
    ..K. cohort of young twins...
  63. ncbi Validation of "prodromal" criteria to detect individuals at ultra high risk of psychosis: 2 year follow-up
    Alison R Yung
    ORYGEN Research Centre and University of Melbourne, Department of Psychiatry, Parkville 3052, Victoria, Australia
    Schizophr Res 105:10-7. 2008
    Identification of individuals "prodromal" for schizophrenia and other psychotic disorders relies on criteria that predict onset within a brief period...
  64. pmc Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions
    P R Corlett
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Brain 130:2387-400. 2007
    ..Our results support a neurobiological theory of delusion formation that implicates aberrant prediction-error signalling, disrupted attentional allocation and associative learning in the formation of delusional beliefs...
  65. ncbi Increased rates of psychosis among immigrants to Sweden: is migration a risk factor for psychosis?
    K Zolkowska
    Department of Psychiatry, Lund University, Malmo, Sweden
    Psychol Med 31:669-78. 2001
    ..Rates of schizophrenia-like psychoses (SLP), i.e. schizophrenia or other non-affective psychosis, among the native-born and immigrant populations were assessed in Malmö, the city in Sweden with the highest proportion of immigrants...
  66. pmc Frontal lobe changes occur early in the course of affective disorders in young people
    Jim Lagopoulos
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, Australia
    BMC Psychiatry 12:4. 2012
    ..Contrasts were carried out between controls subjects and patients cohorts with attenuated syndromes and discrete disorders, separately...
  67. pmc A randomized experimental investigation of reasoning training for people with delusions
    Kerry Ross
    Department of Psychology, Institute of Psychiatry, King s College London, DeCrespigny Park, London, UK
    Schizophr Bull 37:324-33. 2011
    ..It is recommended that lengthier, delusion-related reasoning packages be developed and evaluated...
  68. pmc Abnormal cortisol levels during the day and cortisol awakening response in first-episode psychosis: the role of stress and of antipsychotic treatment
    Valeria Mondelli
    Institute of Psychiatry, King s College London, Division of Psychological Medicine, London, United Kingdom
    Schizophr Res 116:234-42. 2010
    ..Our study shows that antipsychotics normalize diurnal cortisol hyper-secretion but not the blunted cortisol awakening response in FEP; factors other than the excess of psychosocial stress explain HPA axis abnormalities in FEP...
  69. ncbi Virtual reality study of paranoid thinking in the general population
    Daniel Freeman
    Department of Psychology, Institute of Psychiatry, King s College London, London, UK
    Br J Psychiatry 192:258-63. 2008
    ..A fear of others can be instilled by the contemporary political and social climate. Unfounded mistrust is called paranoia, and in severe forms is a central symptom of schizophrenia...
  70. ncbi Childhood abuse as a risk factor for psychotic experiences
    I Janssen
    Department of Psychiatry and Neuropsychology, azM Mondriaan Riagg RIBW Vijverdal Academic Centre, EURON, Maastricht University, MD Maastricht, The Netherlands
    Acta Psychiatr Scand 109:38-45. 2004
    ..To examine the hypothesis that individuals from the general population who report childhood abuse are at increased risk of developing positive psychotic symptoms...
  71. ncbi Evaluation of diagnostic procedures in Swedish patients with schizophrenia and related psychoses
    Birgit Ekholm
    Department of Clinical Neuroscience, Karolinska Institutet and Hospital, R5 00, SE 171 76, Stockholm, Sweden
    Nord J Psychiatry 59:457-64. 2005
    ..It is concluded that for future Swedish large-scale genetic studies focusing on a broad definition of schizophrenia, it would be sufficient to rely on the Swedish register diagnoses of schizophrenic psychosis...
  72. ncbi MMN/P3a deficits in first episode psychosis: comparing schizophrenia-spectrum and affective-spectrum subgroups
    Manreena Kaur
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, Australia
    Schizophr Res 130:203-9. 2011
    ..First-episode psychosis (FEP) patients show reduced amplitudes of the 'MMN/P3a complex', but it is unclear whether this occurs across the FEP spectrum...
  73. ncbi Vitamin D supplementation during the first year of life and risk of schizophrenia: a Finnish birth cohort study
    John McGrath
    Department of Psychiatry, University of Cambridge, Cambridge, UK
    Schizophr Res 67:237-45. 2004
    ..The aim of this study was to explore the association between the use of vitamin D supplements during the first year of life and risk of developing schizophrenia...
  74. pmc Differential targeting of the CA1 subfield of the hippocampal formation by schizophrenia and related psychotic disorders
    Scott A Schobel
    Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Arch Gen Psychiatry 66:938-46. 2009
    ..Because schizophrenia and related disorders have a chronic time course and subtle histopathology, it is difficult to identify which brain regions are differentially targeted...
  75. pmc Prediction of psychosis in youth at high clinical risk: a multisite longitudinal study in North America
    Tyrone D Cannon
    Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Los Angeles, CA 90095
    Arch Gen Psychiatry 65:28-37. 2008
    Early detection and prospective evaluation of individuals who will develop schizophrenia or other psychotic disorders are critical to efforts to isolate mechanisms underlying psychosis onset and to the testing of preventive interventions,..
  76. ncbi Predictors of medication discontinuation by patients with first-episode schizophrenia and schizoaffective disorder
    Delbert G Robinson
    Department of Psychiatry Research, Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
    Schizophr Res 57:209-19. 2002
    ..Although extensively studied in multi-episode patients, little data exist on medication adherence by first-episode patients...
  77. ncbi Distinguishing young people with emerging bipolar disorders from those with unipolar depression
    Elizabeth M Scott
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, 100 Mallet Street, Camperdown, NSW 2050, Australia
    J Affect Disord 144:208-15. 2013
    ..To facilitate early intervention, there is a need to distinguish unipolar versus bipolar illness trajectories in adolescents and young adults with adult-type mood disorders...
  78. ncbi Early detection of psychosis: positive effects on 5-year outcome
    T K Larsen
    Stavanger University Hospital, Psychiatric Clinic, Stavanger, Norway
    Psychol Med 41:1461-9. 2011
    ..However, it is still unknown whether early treatment will lead to a better long-term outcome. This study reports the effects of reducing DUP on 5-year course and outcome...
  79. pmc Jumping to conclusions, a lack of belief flexibility and delusional conviction in psychosis: a longitudinal investigation of the structure, frequency, and relatedness of reasoning biases
    Suzanne H So
    King s College London, Institute of Psychiatry, London, United Kingdom
    J Abnorm Psychol 121:129-39. 2012
    ..Required now is examination of these processes in psychosis groups where there is greater change in delusion conviction, as well as tests of the effects on delusions when these reasoning biases are specifically targeted...
  80. ncbi Genetic variation in the G720/G30 gene locus (DAOA) influences the occurrence of psychotic symptoms in patients with Alzheimer's disease
    Emilio Di Maria
    Department of Neuroscience, Ophthalmology and Genetics, University of Genova, Genova, Italy
    J Alzheimers Dis 18:953-60. 2009
    ..If the results from the present study will be replicated, the glutamate hypothesis could be invoked to explain the occurrence of psychosis in neurodegenerative disorders...
  81. ncbi Comparison of disability and quality of life measures in patients with long-term psychotic disorders and patients with multiple sclerosis: an application of the WHO Disability Assessment Schedule II and WHO Quality of Life-BREF
    Prem Chopra
    University of Melbourne, Melbourne, Australia
    Int J Rehabil Res 31:141-9. 2008
    ..Schedule II (WHODAS II) and WHO Quality of Life-BREF (WHOQOL-BREF) in the assessment of patients with psychotic disorders and multiple sclerosis, and to assess the feasibility and usefulness of such universal measures in the ..
  82. ncbi Follow-up MRI study of the insular cortex in first-episode psychosis and chronic schizophrenia
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Schizophr Res 108:49-56. 2009
    Morphologic abnormalities of the insular cortex have been described in psychotic disorders such as schizophrenia, but it remains unknown whether these abnormalities develop progressively over the course of the illness...
  83. ncbi Decreased BDNF levels in CSF of drug-naive first-episode psychotic subjects: correlation with plasma BDNF and psychopathology
    Anilkumar Pillai
    Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta, GA 30912, USA
    Int J Neuropsychopharmacol 13:535-9. 2010
    ..The parallel changes in BDNF levels in plasma and CSF indicate that plasma BDNF levels reflect the brain changes in BDNF levels in schizophrenia...
  84. ncbi Norwegian version of the Mini-International Neuropsychiatric Interview: feasibility, acceptability and test-retest reliability in an acute psychiatric ward
    J Mordal
    Psychiatric Department, Lovisenberg Deaconal Hospital, N 0440 Oslo, Norway
    Eur Psychiatry 25:172-7. 2010
    ..To assess the feasibility, patient and clinician acceptability and test-retest reliability of the Mini-International Neuropsychiatric Interview (MINI) used by non-psychiatrists in an acute psychiatric ward...
  85. ncbi Clinicopathological significance of psychotic experiences in non-psychotic young people: evidence from four population-based studies
    Ian Kelleher
    Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    Br J Psychiatry 201:26-32. 2012
    ..There has been a lack of research, however, on the immediate clinicopathological significance of psychotic symptoms in adolescence...
  86. ncbi Increase in brain-derived neurotrophic factor in first episode psychotic patients after treatment with atypical antipsychotics
    Ana Gonzalez-Pinto
    University of the Basque Country, Biomedical Research Center in Mental Health Net CIBERSAM, Hospital Santiago Apostol, Vitoria, Spain
    Int Clin Psychopharmacol 25:241-5. 2010
    ..Results suggest that olanzapine can offset the low BDNF levels at the onset of first psychotic episodes, and improving psychotic symptoms. The increase in BDNF levels may be its mechanism of action in improving positive symptoms...
  87. ncbi The diagnostic interview for psychoses (DIP): development, reliability and applications
    D J Castle
    University of Melbourne and Mental Health Research Institute, Melbourne, Australia
    Psychol Med 36:69-80. 2006
    We describe the development, reliability and applications of the Diagnostic Interview for Psychoses (DIP), a comprehensive interview schedule for psychotic disorders.
  88. ncbi The effect of COMT, BDNF, 5-HTT, NRG1 and DTNBP1 genes on hippocampal and lateral ventricular volume in psychosis
    A Dutt
    NIHR Biomedical Research Centre, Institute of Psychiatry King s College London South London and Maudsley NHS Foundation Trust, London, UK
    Psychol Med 39:1783-97. 2009
    Morphometric endophenotypes which have been proposed for psychotic disorders include lateral ventricular enlargement and hippocampal volume reductions...
  89. ncbi Patients with schizophrenia demonstrate dissociation between affective experience and motivated behavior
    Erin A Heerey
    Maryland Psychiatric Research Center, University of Maryland Baltimore, Baltimore, MD, USA
    J Abnorm Psychol 116:268-78. 2007
    ..These data suggest that the motivational deficits in schizophrenia reflect problems in the ability to translate experience into action...
  90. pmc Impact of neurocognition on social and role functioning in individuals at clinical high risk for psychosis
    Ricardo E Carrión
    Department of Psychiatry Research, Zucker Hillside Hospital, NorthShore Long Island Jew ish Health System, Glen Oaks, NY 11004, USA
    Am J Psychiatry 168:806-13. 2011
    ..The authors assessed cognitive impairment in adolescents at clinical high risk for psychosis and examined its impact on social and role functioning...
  91. ncbi Cognitive functioning in schizophrenia, schizoaffective disorder and affective psychoses: meta-analytic study
    Emre Bora
    Melbourne Neuropsychiatry Centre, Alan Gilbert Building, National Neuroscience Facility, Level 3, Victoria 3053, Australia
    Br J Psychiatry 195:475-82. 2009
    ..Cognitive functioning in affective psychosis and schizoaffective disorder is much less studied compared with schizophrenia...
  92. ncbi Behavioural sensitization to daily life stress in psychosis
    I Myin-Germeys
    Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands
    Psychol Med 35:733-41. 2005
    ..In order to validate such a mechanism, the impact of daily life stress on psychosis intensity was investigated in two groups at increased risk of onset (relatives) and relapse (patients) of psychosis...
  93. ncbi Altered brain function directly related to structural abnormalities in people at ultra high risk of psychosis: longitudinal VBM-fMRI study
    P Fusar-Poli
    Department of Psychosis Studies, King s College London, King s Health Partners, Institute of Psychiatry, UK
    J Psychiatr Res 45:190-8. 2011
    ..However, the longitudinal course of these abnormalities, and how they relate to subsequent clinical and functional outcome is relatively unclear...
  94. ncbi ZNF804A may be associated with executive control of attention
    Z Balog
    Department of Physiology, University of Szeged, Faculty of Medicine, Szeged National Psychiatry Center, Balassa u 6, Budapest, Hungary
    Genes Brain Behav 10:223-7. 2011
    ..These results suggest that the genome-wide supported psychosis risk variant of ZNF804A is associated with altered executive control (larger conflict effect), which is a potential endophenotype of psychotic disorders.
  95. pmc Social cognition in psychosis: multidimensional structure, clinical correlates, and relationship with functional outcome
    Francesco Mancuso
    Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at University of California, Los Angeles, CA 90095 6968, USA
    Schizophr Res 125:143-51. 2011
    ..wide range of tasks, and appear to play a key role in explaining poor outcome in schizophrenia and related psychotic disorders. However, little is known about the underlying factor structure of social cognition in people with ..
  96. pmc A randomized controlled trial of cognitive-behavioral treatment for posttraumatic stress disorder in severe mental illness
    Kim T Mueser
    Department of Psychiatry and Community and Family Medicine, Dartmouth Medical School, Concord, New Hampshire, USA
    J Consult Clin Psychol 76:259-71. 2008
    ..The findings suggest that clients with severe mental illness and PTSD can benefit from CBT, despite severe symptoms, suicidal thinking, psychosis, and vulnerability to hospitalizations...
  97. ncbi Five-year follow-up of a randomized multicenter trial of intensive early intervention vs standard treatment for patients with a first episode of psychotic illness: the OPUS trial
    Mette Bertelsen
    Bispebjerg Hospital, Department of Psychiatry, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark
    Arch Gen Psychiatry 65:762-71. 2008
    ..Intensive early treatment for first-episode psychosis has been shown to be effective. It is unknown if the positive effects are sustained for 5 years...
  98. pmc The Lambeth Early Onset (LEO) Team: randomised controlled trial of the effectiveness of specialised care for early psychosis
    Tom K J Craig
    Institute of Psychiatry, De Crespigny Park, London SE5 8AF
    BMJ 329:1067. 2004
    ..To evaluate the effectiveness of a service for early psychosis...
  99. ncbi New directions in the conceptualization of psychotic disorders
    Jerome L Kroll
    Department of Psychiatry, University of Minnesota Medical School and the Community University Health Care Clinic, Minneapolis, MN 55404, USA
    Curr Opin Psychiatry 20:573-7. 2007
    ..Recent studies raise controversies about the nature of psychotic illnesses, and the role of life experiences and drug abuse as causative agents in the onset of psychoses...
  100. ncbi Emotion and psychosis: links between depression, self-esteem, negative schematic beliefs and delusions and hallucinations
    Ben Smith
    UCL, Department of Mental Health Sciences, Archway Campus, Holborn Union Building, Highgate Hill, London, UK
    Schizophr Res 86:181-8. 2006
    ..A., Kuipers, E.K., Fowler, D., Freeman, D., Bebbington, P.E., 2001. A cognitive model of the positive symptoms of psychosis. Psychological Medicine, 31, 189-195] about the role of emotion and negative evaluative beliefs in psychosis...
  101. pmc Specificity of familial transmission of schizophrenia psychosis spectrum and affective psychoses in the New England family study's high-risk design
    Jill M Goldstein
    Division of Women s Health, Mary Horrigan Connors Center for Women s Health and Gender Biology, and Department of Psychiatry, Brigham and Women s Hospital, Boston, Massachusetts 02120, USA
    Arch Gen Psychiatry 67:458-67. 2010
    ..However, few studies have investigated the specificity of the transmission of schizophrenia-psychosis spectrum (SPS) disorders and affective psychoses (APs) or observed high-risk offspring into mid-adulthood...

Research Grants78

  1. Brain Structure and Function in Adolescents after the Fontan Operation
    MICHAEL JOHN RIVKIN; Fiscal Year: 2012
    ..well as specific psychiatric diagnoses including mood, anxiety, attention-deficit/disruptive behavior, and psychotic disorders. Aim 4 will explore the relationship of brain MRI measures to genetic and medical factors...
  2. Prevention Trial of Family Focused Treatment in Youth at Risk for Psychosis
    Tyrone D Cannon; Fiscal Year: 2010
    ..of a major commitment to an early detection/prevention framework for its most debilitating syndromes - the psychotic disorders. The prodromal risk syndrome criteria have resulted in clinical algorithms that are highly effective in ..
  3. Novel Functionally-Selective Serotonin 5HT2 Drugs for Amphetamines Abuse/Disorder
    Drake Morgan; Fiscal Year: 2013
    ..drug development candidates to treat amphetamine and methamphetamine addiction and drug-induced psychotic disorders. Activation of brain 5HT2C receptors or antagonism/inverse agonism of 5HT2A receptors attenuates ..
  4. Building Research Capacity to Improve Mental Health in China across the Lifespan
    Arthur M Kleinman; Fiscal Year: 2013
    ..More than 90% of persons with mental disorders and as many as 25% of persons with severe and disabling psychotic disorders never receive psychiatric care...
  5. Decision support for smoking cessation in young adults with severe mental illness
    MARY FRANCES BRUNETTE; Fiscal Year: 2013
    ..In Year 2, we will conduct an RCT among 60 young smokers with SMI psychotic disorders comparing the EDSS to a computerized version of a standard smoking cessation pamphlet...
  6. Influence of Psychosis on Brain-Behavior Endophenotypes for Bipolar Disorder
    David C Glahn; Fiscal Year: 2012
    ..that could improve the identification and treatment of BPI patients and, potentially, patients with psychotic disorders, independent of their formal diagnosis...
  7. Mitochondrial Abnormalities in Schizophrenia and Bipolar Disorder
    MARQUIS PHILIP VAWTER; Fiscal Year: 2013
    ..SZ, and has a great potential significance in determining future targets for therapy of chronic mood and psychotic disorders. This study fills a void as there has not been an integrative brain study of the entire mitochondrial ..
  8. Gene Expression in Hippocampal Circuits of Bipolars and Schizophrenics
    Francine M Benes; Fiscal Year: 2011
    ..understanding of where pivotal changes in gene expression may be occurring within discrete aspects of HIPP circuitry and whether such changes may be related to genetic or environmental factors associated with the psychotic disorders.
  9. 7/8 Predictors and Mechanisms of Conversion to Psychosis
    JEAN M ADDINGTON; Fiscal Year: 2012
    ..Such knowledge is critical for future efforts at early detection, intervention and prevention of psychotic disorders. PUBLIC HEALTH RELEVANCE: Preventing schizophrenia and other psychoses could relieve an enormous burden of ..
  10. 5/8-Predictors and Mechanisms of Conversion to Psychosis
    Diana O Perkins; Fiscal Year: 2013
    ..Such knowledge is critical for future efforts at early detection, intervention and prevention of psychotic disorders. PUBLIC HEALTH RELEVANCE: Preventing schizophrenia and other psychoses could relieve an enormous burden of ..
  11. Parsing the schizophrenia-bipolar spectrum: an MEG based schizoaffective endophen
    Martin Reite; Fiscal Year: 2010
    ..only confuse and introduce error into studies of pathophysiology, treatment, and outcome of these serious psychotic disorders. Whole head MEG recordings of subjects listening to bursts of 1Kz tones amplitude modulated at 40Hz, ..
  12. Cross Species Imaging of Schizophrenia
    Scott A Schobel; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): I am psychiatrist who specializes in clinical high risk research in psychotic disorders. This proposal describes a translational research training program in patients at clinical risk for psychosis ..
  13. Paternal Germ Line Effects and the Risk of Schizophrenia in Offspring
    Mark G Opler; Fiscal Year: 2012
    ..age and exposure to lead (Pb), a known toxin may increase susceptibility to schizophrenia and other psychotic disorders in offspring...
  14. Attention and Smooth Pursuit in Infants with a Family History of Psychosis
    Sharon K Hunter; Fiscal Year: 2010
    ..are fully present in children this young lends support to the neurodevelopmental hypothesis of primary psychotic disorders. This hypothesis suggests that "events" (i.e...
  15. Examining Deficit Syndrome in an Untreated, Representative SCZ Cohort in China
    Lawrence H Yang; Fiscal Year: 2012
    ..We propose to utilize a representative sample of 389 patients diagnosed with psychotic disorders obtained from a stratified random sample of 4 provinces in China (a sampling frame of 113 million adults)...
  16. Reducing the Duration of Untreated Psychosis through Community Education
    Steven R Lopez; Fiscal Year: 2013
    ..service use and its large proportion of immigrants because immigrants have elevated incidence rates of psychotic disorders. To achieve the overall objective, a multi-level and multi-platform Spanish language Communication Campaign ..
  17. Specialized Treatment Early in Psychosis (STEP): A community health center based
    Vinod H Srihari; Fiscal Year: 2010
    ..by applicant): The guiding question is whether early intervention can improve long term outcomes for psychotic disorders in the U.S...
  18. 2/8-Predictors and Mechanisms of Conversion to Psychosis
    ELAINE FRAN WALKER; Fiscal Year: 2013
    ..Such knowledge is critical for future efforts at early detection, intervention and prevention of psychotic disorders.
  19. IDENTIFICATION OF PSYCHOSIS-RISK TRAITS IN AFRICA
    Daniel Mamah; Fiscal Year: 2013
    ..the progression of symptoms in UHR youth at intervals up to 18 months, identify the rate of transition to psychotic disorders and identify traits indicating progression towards psychosis...
  20. Frontal-Subcortical Development, Movement Abnormalities, and Risk for Psychosis
    Vijay A Mittal; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Psychotic disorders such as schizophrenia have been associated with both frontal lobe dysfunction as well as abnormal regulation of subcortical regions...
  21. Neurotensin an endogenous neuroleptic-like peptide
    BECKY L KINKEAD; Fiscal Year: 2010
    ..effective APD therapy and has the potential to assist in the development of more effective treatments of psychotic disorders. This research is particularly timely as a landmark antipsychotic drug effictiveness study (CATIE, see ..
  22. The MGH Global Psychiatric Clinical Research Training Program
    David C Henderson; Fiscal Year: 2013
    ..services research, child-adolescent psychiatry, disaster/refugee/trauma psychiatry, behavioral medicine, psychotic disorders, and mood disorders...
  23. Sensorimotor abnormalities in childhood onset psychotic disorders
    Donald C Rojas; Fiscal Year: 2013
    ..Our long term goals for this research are to refine the neurobiology of motor deficits in psychotic disorders, develop biomarkers for future family-based studies of genetic risk and evaluate neurobiological ..
  24. Bipolar &Schizophrenia Consortium for Parsing Intermediate Phenotypes
    John A Sweeney; Fiscal Year: 2010
    ..This line of investigation will potentially impact our conceptualization of psychotic disorders, help us make critical strides to identify the pathophysiology of psychosis, and guide development of new ..
  25. Bipolar &Schizophrenia Consortium for Parsing Intermediate Phenotypes
    Godfrey D Pearlson; Fiscal Year: 2012
    ..This line of investigation will potentially impact our conceptualization of psychotic disorders, help us make critical strides to identify the pathophysiology of psychosis, and guide development of new ..
  26. Bipolar &Schizophrenia Consortium for Parsing Intermediate Phenotypes
    Carol A Tamminga; Fiscal Year: 2012
    ..This line of investigation will potentially impact our conceptualization of psychotic disorders, help us make critical strides to identify the pathophysiology of psychosis, and guide development of new ..
  27. Family-Focused Therapy for Youth with Early-Onset Bipolar or Psychotic Disorders
    DAVID JAY MIKLOWITZ; Fiscal Year: 2013
    ..lag in the community adoption and sustainability of family interventions for early-onset mood and psychotic disorders. Our objective is to determine the optimal methods of training and monitoring the delivery of an evidence-..
  28. Efficacy of a Cognitive Remediation Treatment Program for Bipolar Disorder
    Kathryn Eve Lewandowski; Fiscal Year: 2013
    ..130 patients with BD with a history of psychosis recruited from the Psychotic Disorders Programs at McLean Hospital will be randomized into either the CR or computer control group...
  29. Augmenting Social Cognitive Intervention for Veterans with Schizophrenia
    Michael F Green; Fiscal Year: 2013
    ..The ultimate goal of this research program is to improve community outcome for veterans with psychotic disorders by addressing the determinants of functional outcome...
  30. Psychotic disorders in an African setting: Incidence, early course, and treatment
    Ezra S Susser; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Psychotic disorders in an African setting: Incidence, early course, and treatment pathways...
  31. Imaging Hippocampal Function in Psychosis
    Stephan Heckers; Fiscal Year: 2013
    ..We will follow patients for 2 years and measure the change of hippocampal volume in psychotic disorders. We predict that hippocampal activity is abnormal already at the onset of the illness and does not change ..
  32. Early Phase Psychosis: Informing Treatment Decisions
    John M Kane; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Psychotic disorders occurring for the first time in adolescents and young adults pose enormous challenges. Often diagnosis is unclear and potential treatments are not sufficiently evidence-based...
  33. Genetics of Schizophrenia in Oceanic Palau.
    Bernie Devlin; Fiscal Year: 2010
    ..Our principal objective is to identify genetic variation that underlies liability to schizophrenia and other psychotic disorders (henceforth called Scz) in the Oceanic population of Palau...
  34. EEG Biomarkers of Psychosis Risk and Adolescent Neurodevelopment
    Peter Bachman; Fiscal Year: 2013
    ..neuroscientist with skills and expertise to study adolescence as a sensitive period in the development of psychotic disorders such as schizophrenia...
  35. Effects of Maintenance Treatment with Olanzapine vs. Placebo on Brain Structure
    ARISTOTLE NICHOLAS VOINESKOS; Fiscal Year: 2013
    ..that antipsychotics are actually protective against structural brain changes associated with untreated psychotic disorders. With the growing number of younger and older patients receiving antipsychotics, determining the overall ..
  36. The Neural Basis of Delusions in Schizophrenia: Studies of Emotional Perception
    Daphne J Holt; Fiscal Year: 2010
    ..Such early detection methods would provide critical tools for the design of treatment interventions aimed at reducing the severity or preventing the onset of schizophrenia and other psychotic disorders.
  37. Neurobiology of a Mutation in Glycine Metabolism in Psychotic Disorders
    Deborah L Levy; Fiscal Year: 2013
    ....
  38. Disruption of an epigenetic locus controlling EAAC1 expression in schizophrenia
    Marina Myles-Worsley; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Our ongoing 20-year family-genetic study of schizophrenia and other psychotic disorders (SCZ) in the isolated population of Palau provides a valuable resource for examining the genetic and epigenetic ..
  39. Technology-Assisted Assessment of Post-Hospital Adherence in Schizophrenia
    Ethan Moitra; Fiscal Year: 2013
    ..b>Psychotic disorders, in particular, are associated with disproportionately high societal costs related to treatment, disability,..
  40. RESEARCH METHODS CORE
    Dilip V Jeste; Fiscal Year: 2011
    ..practical clinical/behavioral trials for middle-aged and older persons with schizophrenia and other psychotic disorders. This aim will be met through (a) instrument and methods development, testing, and implementation;(b) ..
  41. Simulated Job Interview Training for People with Psychiatric Disorders
    DALE EDWARD OLSEN; Fiscal Year: 2012
    ..g., schizophrenia, other psychotic disorders, mood disorders, PTSD)...
  42. PATHOPHYSIOLOGY OF COGNITIVE DISABILITY IN SCHIZOPHRENIA
    Cameron S Carter; Fiscal Year: 2013
    ..Much of the preceding research on the pathophysiology of psychotic disorders has followed the categorical distinction between schizophrenia (SZ) and Bipolar Disorder (BD)...
  43. Training in Schizophrenia and Psychotic Disorders: From Animal Models to Patients
    Jonathan A Javitch; Fiscal Year: 2013
    ..This remains the case today, and the core of the training program has been strengthened by the changes in the current application. ..
  44. Forensic Assertive Community Treatment: An Emerging Model of Service Delivery
    J Steven Lamberti; Fiscal Year: 2010
    ..Treatment (FACT) as an adaptation of the Assertive Community Treatment (ACT) model for adults with psychotic disorders in the criminal justice system...
  45. Effectiveness of Psychosocial Treatment for Inpatients with Psychosis
    Brandon A Gaudiano; Fiscal Year: 2013
    ..by applicant): Effectiveness of Psychosocial Treatment for Inpatients with Psychosis Patients with psychotic disorders frequently require treatment at inpatient hospital settings during periods of acute illness for crisis ..
  46. Trajectories of recovery from psychosis over two decades
    ROMAN I KOTOV; Fiscal Year: 2013
    ..The application is aligned with the NIMH Strategic Plan in seeking to (1) chart trajectories of psychotic disorders from an early phase of the illness and (2) elucidate links between neurobiological functioning and real-..
  47. Cognitive and Affective Dysfunctions in the Psychoses
    Keith H Nuechterlein; Fiscal Year: 2013
    ..program focuses on developing research scientists who focus on cognitive and affective dysfunctions in psychotic disorders. The program will utilize a training model that emphasizes the skills needed to bring concepts and ..
  48. The Genetics of Psychosis: Towards a Dimensional Approach
    Pamela DeRosse; Fiscal Year: 2010
    ..for association with dimensions of psychosis in 1) a sample of 1,027 patients with /^xis I affective or psychotic disorders derived from the Zucker Hillside Hospital Genomics Initiative database and 2) a large, clinically ..
  49. Training in Early Detection and Prevention in Psychiatric Disorders
    Michelle G Craske; Fiscal Year: 2013
    We propose a novel program for post-doctoral training in early detection and prevention of psychotic disorders, mood disorders, and anxiety disorders...
  50. Cognitive Remediation and Work Therapy in the Initial Phase of Substance Abuse Tr
    Morris D Bell; Fiscal Year: 2011
    ..reported on a model of providing CRT with work therapy (WT) in an outpatient context for people with psychotic disorders, which showed significant improvements in executive function and working memory, and in important ..
  51. Improving Clinician Recognition of Early Psychosis with an Interactive Online Cou
    Diana O Perkins; Fiscal Year: 2013
    ..delay is one of the most serious deficiencies in the clinical management of schizophrenia and related psychotic disorders. Untreated psychosis is distressing, derails normal development and is associated with behavioral ..
  52. A Genetic Test for Drug-Induced Dyskinesia Risk Determination
    Abraham Kovoor; Fiscal Year: 2007
    ..Antipsychotic drugs have revolutionized the treatment of schizophrenia and psychotic disorders but a debilitating side-effect of "typical" antipsychotics is TD, an irreversible movement disorder of ..
  53. GENETIC ANALYSIS OF MG-TETRAPYRROLE BIOSYNTHESIS
    Carl Bauer; Fiscal Year: 2005
    ..Clinical manifestations of overproducing these intermediates range from simple skin lesions, to psychotic disorders, to death...
  54. Treatment of Psychotic Disorders in Youth
    Linmarie Sikich; Fiscal Year: 2006
    ..become an independent investigator with a focus on intervention research in children and adolescents with psychotic disorders. There is a dearth of research, particularly psychopharmacologic, on the treatment of psychotic disorders ..
  55. Development of a Novel Cognitive Remediation Program for 22q11 Deletion Syndrome
    Vandana Shashi; Fiscal Year: 2013
    ..neurodevelopmental disorder, have a remarkably high risk (25-40%) of developing schizophrenia and other psychotic disorders in late adolescence/adulthood...
  56. EARLY ONSET SCHIZOPHRENIA
    Jon McClellan; Fiscal Year: 1999
    ..Principal Investigator will carry out a 2 year prospective follow-up study of all subjects with early onset psychotic disorders admitted to CSTC over the five year period of the award...
  57. Longitudinal Imaging of Patients at Clinical Risk for Psychosis.
    Scott A Small; Fiscal Year: 2013
    ..of the pathophysiology of emergent psychotic illness, both of which are key to developing preventative interventions in an effort to reduce the significant morbidity of schizophrenia and related psychotic disorders.
  58. Symptom Dimensions in Psychosis
    Berit Kerner; Fiscal Year: 2009
    ..of the candidate is to understand the cognitive, emotional, behavioral andneurophysiologic abnormalities of psychotic disorders, their overlaps and their differences and to link these to molecular abnormalities...
  59. CONTINUITY OF CARE & OUTCOME OF SEVERE MENTAL DISORDERS
    Ramin Mojtabai; Fiscal Year: 2003
    ..The impact of early treatment career on the subsequent course and outcome of psychotic of psychotic disorders has attracted much attention in recent years...
  60. PHENCYCLIDINE TOXICITY: NEUROPSYCHIATRIC IMPLICATIONS
    John Olney; Fiscal Year: 1992
    ..PCP-like peptidergic neuromodulator and that dysfunction of this neuromodulatory system might underly psychotic disorders such as schizophrenia...
  61. Development of HTS Assays for Sub-Threshold Potassium Channels
    Timothy Jegla; Fiscal Year: 2006
    ..Relevance: A wide variety of brain diseases including epilepsy, anxiety and psychotic disorders involve pathological hyperexcitability of nervous system...
  62. NEUROBIOLOGY OF CANNABIS EFFECTS
    DEEPAK D SOUZA; Fiscal Year: 2009
    ..Epidemiological data suggest that cannabis is a modest risk for the emergence of psychosis and psychotic disorders. Further, a recent report suggests that polymorphisms of the gene for the enzyme catechol-O-..
  63. RURAL OUTREACH ADVOCACY AND DIRECT SERVICES (ROADS)
    Joseph Bevilacqua; Fiscal Year: 1992
    ..disorder, bipolar disorder, major depression recurrent with psychotic features, and/or other psychotic disorders. An anticipated 120 patients will participate; 60 in each group...
  64. Impact of Maternal Psychotic Disorders on Pediatric Health Care Utilization
    SARA CULLEN; Fiscal Year: 2009
    ..particularly preventive and primary care, it is possible that mothers with SMI, particularly women with psychotic disorders, use less preventive pediatric health care for their children...
  65. Neuropeptidase Function
    David Rodgers; Fiscal Year: 2004
    ..known to be modulated by many centrally active agents and affected in a number of disease states-including psychotic disorders, Alzheimer's disease, and hypertension...
  66. Serotonin Glutamate Interactions in Prefrontal Cortex
    Gerard Marek; Fiscal Year: 2001
    ..for 5-HT2A receptor-mediated responses that will lead to the development of novel treatments for mood and psychotic disorders. The serotonin2A (5-HT2A) receptor has been implicated in the pathophysiology of depression, suicide and ..
  67. Stigma & Behavioral Health in Urban Employers from China & US
    Patrick Corrigan; Fiscal Year: 2007
    ..People with three such disorders will be the focus of this study: psychotic disorders, alcohol abuse disorders, and HIV/AIDS...
  68. NEURONAL MIGRATION FROM BASAL FOREBRAIN TO NEOCORTEX
    Stewart Anderson; Fiscal Year: 2002
    ..In addition, the candidate is committed to enhancing clinical skills with a focus on psychotic disorders. These goals will be attained through a program which devotes 75-80% time to research and no more than 25% ..
  69. Neuropeptidase Function
    David Rodgers; Fiscal Year: 2007
    ..zinc metallopeptidases inactivate the neuropeptide neurotensin and are potential therapeutic targets for psychotic disorders and treatment of pain. They have an unusual property shared by a number of neuropeptidases...
  70. SCHIZOPHRENIC COGNITION--A LONGITUDINAL STUDY
    Martin Harrow; Fiscal Year: 2001
    ..persists or recurs over time in schizophrenia, and in schizoaffective disorders, but remits in other psychotic disorders. Hypothesis 3: Negative-deficit symptoms persist in schizophrenia, and they identify a subgroup of poor ..
  71. SCHIZOPHRENIC COGNITION: A LONGITUDINAL STUDY
    Martin Harrow; Fiscal Year: 1992
    ..persists or recurs over time in schizophrenia, and in schizoaffective disorders, but remits in other psychotic disorders. Hypothesis 3: Negative-deficit symptoms persist in schizophrenia, and they identify a subgroup of poor ..
  72. Sustained Release Olanzapine
    Thomas Smith; Fiscal Year: 2004
    The long-term goal of this research is to minimize morbidity associated with psychotic disorders by developing injectable long-acting formulations of olanzapine (Zyprexa/R), currently a leading atypical antipsychotic agent FDA approved ..
  73. An Exploratory Study of Naltrexone Plus Aripiprazole for Alcohol Dependence
    Raymond Anton; Fiscal Year: 2009
    ..Differing from naltrexone, aripiprazole is an FDA approved medication for the treatment of psychotic disorders which works by stabilizing the dopamine system, a neurochemical system known to play a large role in ..