borderline personality disorder

Summary

Summary: A personality disorder marked by a pattern of instability of interpersonal relationships, self-image, and affects, and marked impulsivity beginning by early adulthood and present in a variety of contexts. (DSM-IV)

Top Publications

  1. ncbi Psychiatric aspects of impulsivity
    F G Moeller
    Department of Psychiatry and Behavioral Sciences, University of Texas Houston Health Science Center, 77030, USA
    Am J Psychiatry 158:1783-93. 2001
  2. ncbi Amygdala hyperreactivity in borderline personality disorder: implications for emotional dysregulation
    Nelson H Donegan
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520 8098, USA
    Biol Psychiatry 54:1284-93. 2003
  3. ncbi Posttraumatic stress disorder and fMRI activation patterns of traumatic memory in patients with borderline personality disorder
    Martin Driessen
    Center of Psychiatry and Psychological Medicine, Gilead Hospital Bethel, Bielefeld, Germany, Bielefeld
    Biol Psychiatry 55:603-11. 2004
  4. ncbi Elevated pain thresholds correlate with dissociation and aversive arousal in patients with borderline personality disorder
    Petra Ludäscher
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Germany
    Psychiatry Res 149:291-6. 2007
  5. ncbi Intra-individual reaction time variability in schizophrenia, depression and borderline personality disorder
    Stefan Kaiser
    University of Heidelberg, Department of Psychiatry, Section Experimental Psychopathology, Voss Strasse 4, 69115 Heidelberg, Germany
    Brain Cogn 66:73-82. 2008
  6. ncbi Failure of frontolimbic inhibitory function in the context of negative emotion in borderline personality disorder
    David Silbersweig
    Department of Psychiatry, Box 140, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Am J Psychiatry 164:1832-41. 2007
  7. ncbi Borderline personality disorder
    Falk Leichsenring
    Department of Psychosomatics and Psychotherapy, University of Giessen, Germany
    Lancet 377:74-84. 2011
  8. ncbi Pharmacotherapy for borderline personality disorder: Cochrane systematic review of randomised trials
    Klaus Lieb
    Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Untere Zahlbacher Str 8, D 55131 Mainz, Germany
    Br J Psychiatry 196:4-12. 2010
  9. pmc The rupture and repair of cooperation in borderline personality disorder
    Brooks King-Casas
    Computational Psychiatry Unit and Department of Neuroscience, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Science 321:806-10. 2008
  10. ncbi Volumes of the hippocampus and amygdala in patients with borderline personality disorder: a meta-analysis
    Paulo Menezes Nunes
    Department of Neurosciences and Mental Health, School of Medicine, Federal University of Bahia, Salvador, Brazil
    J Pers Disord 23:333-45. 2009

Detail Information

Publications365 found, 100 shown here

  1. ncbi Psychiatric aspects of impulsivity
    F G Moeller
    Department of Psychiatry and Behavioral Sciences, University of Texas Houston Health Science Center, 77030, USA
    Am J Psychiatry 158:1783-93. 2001
    ..The authors discuss the relationship of impulsivity to psychiatric disorders and present selected hypotheses regarding the reasons for these relationships...
  2. ncbi Amygdala hyperreactivity in borderline personality disorder: implications for emotional dysregulation
    Nelson H Donegan
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520 8098, USA
    Biol Psychiatry 54:1284-93. 2003
    Disturbed interpersonal relations and emotional dysregulation are fundamental aspects of borderline personality disorder (BPD)...
  3. ncbi Posttraumatic stress disorder and fMRI activation patterns of traumatic memory in patients with borderline personality disorder
    Martin Driessen
    Center of Psychiatry and Psychological Medicine, Gilead Hospital Bethel, Bielefeld, Germany, Bielefeld
    Biol Psychiatry 55:603-11. 2004
    Early traumatization and additional posttraumatic stress disorder are frequent in patients with borderline personality disorder (BPD)...
  4. ncbi Elevated pain thresholds correlate with dissociation and aversive arousal in patients with borderline personality disorder
    Petra Ludäscher
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Germany
    Psychiatry Res 149:291-6. 2007
    In addition to reduced pain perception, patients with borderline personality disorder (BPD) show higher pain thresholds under subjective stress conditions as compared with non-stress conditions...
  5. ncbi Intra-individual reaction time variability in schizophrenia, depression and borderline personality disorder
    Stefan Kaiser
    University of Heidelberg, Department of Psychiatry, Section Experimental Psychopathology, Voss Strasse 4, 69115 Heidelberg, Germany
    Brain Cogn 66:73-82. 2008
    ..IIV measures obtained in a Go/Nogo task from patients with schizophrenia, major depression and borderline personality disorder. IIV was increased for patients with schizophrenia...
  6. ncbi Failure of frontolimbic inhibitory function in the context of negative emotion in borderline personality disorder
    David Silbersweig
    Department of Psychiatry, Box 140, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Am J Psychiatry 164:1832-41. 2007
    The authors sought to test the hypothesis that in patients with borderline personality disorder, the ventromedial prefrontal cortex and associated regions would not be activated during a task requiring motor inhibition in the setting of ..
  7. ncbi Borderline personality disorder
    Falk Leichsenring
    Department of Psychosomatics and Psychotherapy, University of Giessen, Germany
    Lancet 377:74-84. 2011
    Recent research findings have contributed to an improved understanding and treatment of borderline personality disorder. This disorder is characterised by severe functional impairments, a high risk of suicide, a negative effect on the ..
  8. ncbi Pharmacotherapy for borderline personality disorder: Cochrane systematic review of randomised trials
    Klaus Lieb
    Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Untere Zahlbacher Str 8, D 55131 Mainz, Germany
    Br J Psychiatry 196:4-12. 2010
    Many patients with borderline personality disorder receive pharmacological treatment, but there is uncertainty about the usefulness of such therapies.
  9. pmc The rupture and repair of cooperation in borderline personality disorder
    Brooks King-Casas
    Computational Psychiatry Unit and Department of Neuroscience, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Science 321:806-10. 2008
    ..We recruited 55 individuals afflicted with borderline personality disorder (BPD) to play a multiround economic exchange game with healthy partners...
  10. ncbi Volumes of the hippocampus and amygdala in patients with borderline personality disorder: a meta-analysis
    Paulo Menezes Nunes
    Department of Neurosciences and Mental Health, School of Medicine, Federal University of Bahia, Salvador, Brazil
    J Pers Disord 23:333-45. 2009
    Individuals with borderline personality disorder (BPD) often exhibit impulsive and aggressive behavior...
  11. ncbi A pilot study of the DBT coach: an interactive mobile phone application for individuals with borderline personality disorder and substance use disorder
    Shireen L Rizvi
    School of Applied and Professional Psychology, Rutgers University, Piscataway, NJ 08854, USA
    Behav Ther 42:589-600. 2011
    ..therapy (DBT) has received strong empirical support and is practiced widely as a treatment for borderline personality disorder (BPD) and BPD with comorbid substance use disorders (BPD-SUD)...
  12. ncbi Increased DNA methylation of neuropsychiatric genes occurs in borderline personality disorder
    Gerhard Dammann
    Psychiatric Hospital, Muensterlingen, Switzerland
    Epigenetics 6:1454-62. 2011
    b>Borderline personality disorder (BPD) is a complex psychiatric disease of increasing importance. Epigenetic alterations are hallmarks for altered gene expression and could be involved in the etiology of BPD...
  13. pmc Response to psychotherapy in borderline personality disorder and methylation status of the BDNF gene
    N Perroud
    Department of Psychiatry, University of Geneva, Chene Bourg, Switzerland
    Transl Psychiatry 3:e207. 2013
    ..of methylation at BDNF CpG exons I and IV as well as plasma BDNF protein levels in 115 subjects with borderline personality disorder (BPD) and 52 controls...
  14. ncbi Axis I comorbidity of borderline personality disorder
    M C Zanarini
    Laboratory for the Study of Adult Development, McLean Hospital, Belmont, MA 02478, USA
    Am J Psychiatry 155:1733-9. 1998
    ..study was to assess the lifetime rates of occurrence of a full range of DSM-III-R axis I disorders in a group of patients with criteria-defined borderline personality disorder and comparison subjects with other personality disorders.
  15. ncbi Borderline personality disorder
    Klaus Lieb
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Hauptstrasse 5, D 79104 Freiburg, Germany
    Lancet 364:453-61. 2004
    b>Borderline personality disorder is characterised by a pervasive pattern of instability in affect regulation, impulse control, interpersonal relationships, and self-image...
  16. pmc Prevalence, correlates, disability, and comorbidity of DSM-IV borderline personality disorder: results from the Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions
    Bridget F Grant
    Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 9304, USA
    J Clin Psychiatry 69:533-45. 2008
    To present nationally representative findings on prevalence, sociodemographic correlates, disability, and comorbidity of borderline personality disorder (BPD) among men and women.
  17. ncbi Oxytocin administration attenuates stress reactivity in borderline personality disorder: a pilot study
    D Simeon
    Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine and Beth Israel Medical Center, 317 East 17th Street, New York, NY, USA
    Psychoneuroendocrinology 36:1418-21. 2011
    ..We thus hypothesized that oxytocin would attenuate emotional and hormonal responses to stress in borderline personality disorder (BPD)...
  18. ncbi Dissociative symptoms are positively related to stress in borderline personality disorder
    C E Stiglmayr
    Department of Clinical Psychology and Psychotherapy, Free University of Berlin, Berlin, Germany
    Acta Psychiatr Scand 117:139-47. 2008
    According to DSM-IV criteria, dissociative symptoms in borderline personality disorder (BPD) occur in response to stress. Empirical evidence is, however, lacking.
  19. ncbi Frontolimbic brain abnormalities in patients with borderline personality disorder: a volumetric magnetic resonance imaging study
    Ludger Tebartz van Elst
    Department of Psychiatry and Psychotherapy, University of Freiburg, Freiburg, Germany
    Biol Psychiatry 54:163-71. 2003
    ..One previous study reported volume loss of the hippocampus and the amygdala in patients with borderline personality disorder. We measured limbic and prefrontal brain volumes to test the hypothesis that frontolimbic brain ..
  20. ncbi A randomized trial of dialectical behavior therapy versus general psychiatric management for borderline personality disorder
    Shelley F McMain
    Centre for Addiction and Mental Health, 33 Russell Street, Toronto, Ontario, Canada
    Am J Psychiatry 166:1365-74. 2009
    ..with general psychiatric management, including a combination of psychodynamically informed therapy and symptom-targeted medication management derived from specific recommendations in APA guidelines for borderline personality disorder.
  21. ncbi A screening measure for BPD: the McLean Screening Instrument for Borderline Personality Disorder (MSI-BPD)
    Mary C Zanarini
    Laboratory for the Study for Adult Development, McLean Hospital, Belmont, MA 02478, USA
    J Pers Disord 17:568-73. 2003
    b>Borderline personality disorder (BPD) is a common psychiatric disorder that is often overlooked in treatment settings...
  22. ncbi The latest neuroimaging findings in borderline personality disorder
    Jana Mauchnik
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Curr Psychiatry Rep 12:46-55. 2010
    This review provides an overview of the most recent neuroimaging findings in borderline personality disorder. The contributions of the structural and functional imaging studies of the past 3 years are presented to help us better ..
  23. ncbi Psychological therapies for people with borderline personality disorder
    Jutta M Stoffers
    Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Freiburg, Germany
    Cochrane Database Syst Rev 8:CD005652. 2012
    Psychotherapy is regarded as the first-line treatment for people with borderline personality disorder. In recent years, several disorder-specific interventions have been developed...
  24. ncbi Magnetic resonance imaging of hippocampal and amygdala volume in women with childhood abuse and borderline personality disorder
    Christian G Schmahl
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Hauptstrasse 5, D 79104 Freiburg, Germany
    Psychiatry Res 122:193-8. 2003
    b>Borderline personality disorder (BPD) is a common disorder associated with emotional dysregulation and other symptoms that have been hypothesized to be related to dysfunction of limbic brain areas including hippocampus and amygdala...
  25. pmc Reduced amygdala and hippocampus size in trauma-exposed women with borderline personality disorder and without posttraumatic stress disorder
    Godehard Weniger
    Department of Social and General Psychiatry, University of Zurich, Switzerland
    J Psychiatry Neurosci 34:383-8. 2009
    ..However, studies on individuals with borderline personality disorder (BPD) are rare, and studies on trauma-exposed patients with BPD but without PTSD are lacking.
  26. ncbi Axis I comorbidity in patients with borderline personality disorder: 6-year follow-up and prediction of time to remission
    Mary C Zanarini
    McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    Am J Psychiatry 161:2108-14. 2004
    The purpose of this study was to assess the prevalence of axis I disorders among patients with borderline personality disorder over 6 years of prospective follow-up.
  27. ncbi Affect regulation and pain in borderline personality disorder: a possible link to the understanding of self-injury
    Inga Niedtfeld
    Department of Psychosomatic Medicine, Central Institute of Mental Health Mannheim, University of Heidelberg, Heidelberg, Germany
    Biol Psychiatry 68:383-91. 2010
    Patients with borderline personality disorder (BPD) experience intense emotions and often show a deficiency of emotion regulation skills. Moreover, they display high prevalence rates of self-injurious behavior...
  28. ncbi Transference-focused psychotherapy v. treatment by community psychotherapists for borderline personality disorder: randomised controlled trial
    Stephan Doering
    Department of Prosthodontics and Material Sciences, University of Muenster, Waldeyerstrasse 30 48149 Muenster, Germany
    Br J Psychiatry 196:389-95. 2010
    Transference-focused psychotherapy is a manualised treatment for borderline personality disorder.
  29. pmc Neural correlates of emotion processing in borderline personality disorder
    Harold W Koenigsberg
    Mount Sinai School of Medicine, New York, NY, United States
    Psychiatry Res 172:192-9. 2009
    Emotional instability is a hallmark feature of borderline personality disorder (BPD), yet its biological underpinnings are poorly understood...
  30. ncbi Shame and implicit self-concept in women with borderline personality disorder
    NICOLAS RUSCH
    Department of Psychiatry and Psychotherapy, University of Freiburg, Hauptstrasse 5, D 79104 Freiburg, Germany
    Am J Psychiatry 164:500-8. 2007
    Shame is considered to be a central emotion in borderline personality disorder and to be related to self-injurious behavior, chronic suicidality, and anger-hostility...
  31. ncbi Two-year randomized controlled trial and follow-up of dialectical behavior therapy vs therapy by experts for suicidal behaviors and borderline personality disorder
    Marsha M Linehan
    Behavioral Research and Therapy Clinics, Department of Psychology, University of Washington, Seattle, WA 98195 1525, USA
    Arch Gen Psychiatry 63:757-66. 2006
    Dialectical behavior therapy (DBT) is a treatment for suicidal behavior and borderline personality disorder with well-documented efficacy.
  32. pmc Ten-year course of borderline personality disorder: psychopathology and function from the Collaborative Longitudinal Personality Disorders study
    John G Gunderson
    McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    Arch Gen Psychiatry 68:827-37. 2011
    b>Borderline personality disorder (BPD) is traditionally considered chronic and intractable.
  33. pmc Aberrant connectivity of resting-state networks in borderline personality disorder
    Robert Christian Wolf
    Center of Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Germany
    J Psychiatry Neurosci 36:402-11. 2011
    ..studies have reported regionally abnormal activation of the frontal cortex in individuals with borderline personality disorder (BPD) during cognitive and affective task performance...
  34. ncbi Yi-gan san for the treatment of borderline personality disorder: an open-label study
    Tsuyshi Miyaoka
    Department of Psychiatry, Shimane University School of Medicine, 89 1 Enyacho, Izumo 693 8501, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:150-4. 2008
    Numerous medications have been tested on patients with borderline personality disorder (BPD). Although many of these medications have been demonstrated to be useful, no clear main treatment for BPD has emerged...
  35. ncbi Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD): a continuous measure of DSM-IV borderline psychopathology
    Mary C Zanarini
    Department of Psychiatry, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Pers Disord 17:233-42. 2003
    The purpose of this study was to assess the psychometric properties of the Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD), the first clinician-administered scale for the assessment of change in DSM-IV borderline ..
  36. ncbi A voxel-based morphometric MRI study in female patients with borderline personality disorder
    N Rusch
    Department of Psychiatry and Psychotherapy, University of Freiburg, Freiburg, Germany
    Neuroimage 20:385-92. 2003
    Subtle prefrontal and limbic structural abnormalities have been reported in borderline personality disorder (BPD)...
  37. ncbi Hippocampal volume in borderline personality disorder with and without comorbid posttraumatic stress disorder: a meta-analysis
    E Rodrigues
    Department of Neurosciences and Mental Health, School of Medicine, Federal University of Bahia, Salvador, Brazil
    Eur Psychiatry 26:452-6. 2011
    Several studies have found a reduction in hippocampal volume in borderline personality disorder (BPD) patients.
  38. ncbi Suicidal behavior in borderline personality disorder: prevalence, risk factors, prediction, and prevention
    Donald W Black
    The Department of Psychiatry, University of Iowa Roy J and Lucille A Carver College of Medicine, USA
    J Pers Disord 18:226-39. 2004
    Suicidal behavior is frequent in patients with borderline personality disorder (BPD); at least three-quarters of these patients attempt suicide and approximately 10% eventually complete suicide...
  39. ncbi Anatomical MRI study of borderline personality disorder patients
    Paolo Brambilla
    Division of Mood and Anxiety Disorders, Department of Psychiatry, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Psychiatry Res 131:125-33. 2004
    Hippocampal volume reduction has been reported in patients with borderline personality disorder (BPD), and is hypothesized to be associated with traumatic childhood experiences...
  40. ncbi Estimating the prevalence of borderline personality disorder in psychiatric outpatients using a two-phase procedure
    Marilyn I Korzekwa
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Compr Psychiatry 49:380-6. 2008
    The prevalence of borderline personality disorder (BPD) in outpatient clinics varies greatly (7%-27%) depending on the setting and methodology...
  41. pmc The course of eating disorders in patients with borderline personality disorder: a 10-year follow-up study
    Mary C Zanarini
    McLean Hospital, Belmont, Massachusetts 02478, USA
    Int J Eat Disord 43:226-32. 2010
    The purpose of this study was to describe the longitudinal course of eating disorders in patients with borderline personality disorder.
  42. ncbi Bordering on bipolar: the overlap between borderline personality and bipolarity
    Carissa M Coulston
    CADE Clinic, Department of Psychiatry, Royal North Shore Hospital, St Leonards, NSW 2065, Australia
    Aust N Z J Psychiatry 46:506-21. 2012
    There is much debate over whether borderline personality disorder (BPD) belongs to the bipolar spectrum...
  43. ncbi Auditory verbal hallucinations in patients with borderline personality disorder are similar to those in schizophrenia
    C W Slotema
    Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands
    Psychol Med 42:1873-8. 2012
    Auditory verbal hallucinations (AVH) in patients with borderline personality disorder (BPD) are frequently claimed to be brief, less severe and qualitatively different from those in schizophrenia, hence the term 'pseudohallucinations'...
  44. ncbi Effectiveness of partial hospitalization in the treatment of borderline personality disorder: a randomized controlled trial
    A Bateman
    Halliwick Day Unit, St Ann s Hospital
    Am J Psychiatry 156:1563-9. 1999
    This study compared the effectiveness of psychoanalytically oriented partial hospitalization with standard psychiatric care for patients with borderline personality disorder.
  45. ncbi Distress and affective dysregulation in patients with borderline personality disorder: a psychophysiological ambulatory monitoring study
    Ulrich W Ebner-Priemer
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, 68072 Mannheim, Germany
    J Nerv Ment Dis 196:314-20. 2008
    b>Borderline personality disorder (BPD) is characterized by enduring psychological distress and affective dysregulation. Several models have linked both phenomena, but are lacking empirical support...
  46. pmc Morphometric differences in central stress-regulating structures between women with and without borderline personality disorder
    Andrea Kuhlmann
    Department for General Psychiatry, University Hospital Heidelberg, Heidelberg, Germany
    J Psychiatry Neurosci 38:129-37. 2013
    ..physiologic stress response seem to play an important role in the pathogenesis and maintenance of borderline personality disorder (BPD)...
  47. ncbi Neuronal correlates of cognitive reappraisal in borderline patients with affective instability
    Lars Schulze
    Department of Psychiatry and Psychotherapy, University of Rostock, Rostock, Germany
    Biol Psychiatry 69:564-73. 2011
    b>Borderline personality disorder has been characterized by enhanced emotional reactivity and deficient emotion regulation in behavioral and functional imaging studies...
  48. ncbi Psychometric properties of the Borderline Symptom List (BSL)
    Martin Bohus
    Department of Psychosomatics and Psychotherapy, Central Institute of Mental Health Mannheim, Mannheim, Germany
    Psychopathology 40:126-32. 2007
    ..The items are based on the criteria of the DSM-IV, the Diagnostic Interview for Borderline Personality Disorder - revised version, the opinions of clinical experts and borderline patients...
  49. ncbi Emotional vulnerability in borderline personality disorder is cue specific and modulated by traumatization
    Anke Limberg
    Department of Biological and Clinical Psychology, University of Greifswald, Greifswald, Germany
    Biol Psychiatry 69:574-82. 2011
    ..vulnerability (intense, easily triggered affective reactions) is considered a core symptom in borderline personality disorder (BPD), but evidence from psychophysiological studies for this hypothesis is not very consistent...
  50. ncbi Aversive tension in patients with borderline personality disorder: a computer-based controlled field study
    C E Stiglmayr
    Department of Psychiatry and Psychotherapy, Albert Ludwigs University Freiburg, Germany
    Acta Psychiatr Scand 111:372-9. 2005
    This study was designed to examine the subjective appraisal of aversive tension under conditions of daily life in patients with borderline personality disorder (BPD).
  51. ncbi Psychophysiological ambulatory assessment of affective dysregulation in borderline personality disorder
    Ulrich W Ebner-Priemer
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Postfach 122120, 68072 Mannheim, Germany
    Psychiatry Res 150:265-75. 2007
    ..believe that pervasive problems in affect regulation constitute the central area of dysfunction in borderline personality disorder (BPD). However, data is sparse and inconclusive...
  52. ncbi Neural correlates of the individual emotional Stroop in borderline personality disorder
    Katja Wingenfeld
    Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Psychoneuroendocrinology 34:571-86. 2009
    Emotional dysregulation is a key feature of borderline personality disorder (BPD) with altered inhibitory functions having suggested as being crucial...
  53. ncbi Neural correlates of impaired emotional discrimination in borderline personality disorder: an fMRI study
    Marc Guitart-Masip
    Cognitive Neuroscience Research Unit, Department of Psychiatry and Forensic Medicine, Universitat Autonoma de Barcelona, Hospital del Mar, Barcelona, Spain
    Prog Neuropsychopharmacol Biol Psychiatry 33:1537-45. 2009
    A common approach to study neuronal aspects of emotional reactivity of borderline personality disorder (BPD) is to study the brain response to emotional faces with functional magnetic resonance imaging (fMRI)...
  54. ncbi Dorsolateral prefrontal cortex and hippocampus sustain impulsivity and aggressiveness in borderline personality disorder
    M Sala
    Department of Mental Health, Azienda Sanitaria Locale Alessandria, Alessandria Italy
    J Affect Disord 131:417-21. 2011
    b>Borderline Personality Disorder (BPD) patients are characterized by increased levels of aggressivity and reduction of impulse control, which are behavioural dimensions mainly sustained by hippocampus and dorsolateral prefrontal cortex (..
  55. ncbi Theory of mind and emotion regulation difficulties in adolescents with borderline traits
    Carla Sharp
    Department of Psychology, University of Houston, Houston, TX 77024, USA
    J Am Acad Child Adolesc Psychiatry 50:563-573.e1. 2011
    ..mind or mentalizing) have been proposed as explanations for disturbances of interpersonal behavior in borderline personality disorder (BPD)...
  56. pmc Enhanced 'Reading the Mind in the Eyes' in borderline personality disorder compared to healthy controls
    E A Fertuck
    Department of Psychiatry, Columbia University New York State Psychiatric Institute, New York, NY 10032, USA
    Psychol Med 39:1979-88. 2009
    b>Borderline personality disorder (BPD) is partly characterized by chronic instability in interpersonal relationships, which exacerbates other symptom dimensions of the disorder and can interfere with treatment engagement...
  57. ncbi Reduced prefrontal and orbitofrontal gray matter in female adolescents with borderline personality disorder: is it disorder specific?
    Romuald Brunner
    Department of Child and Adolescent Psychiatry, Center for Psychosocial Medicine University of Heidelberg, Blumenstrasse 8, Heidelberg, Germany
    Neuroimage 49:114-20. 2010
    There is evidence that adults with borderline personality disorder (BPD) are characterized by abnormalities in frontolimbic brain areas...
  58. ncbi Mentalization: ontogeny, assessment, and application in the treatment of borderline personality disorder
    Lois W Choi-Kain
    Department of Psychiatry, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    Am J Psychiatry 165:1127-35. 2008
    ..development of the concept of mentalization, its applications in the understanding and treatment of borderline personality disorder, and the issue of its assessment...
  59. ncbi Neuropsychological and behavioural disinhibition in adult ADHD compared to borderline personality disorder
    K Lampe
    Department of Psychiatry and Psychotherapy, RWTH Aachen, University Hospital, Rostock, Germany
    Psychol Med 37:1717-29. 2007
    ..disorder, the question remains of how specific the inhibitory deficit is in adults and whether it distinguishes ADHD from borderline personality disorder (BPD), with which it shares several clinical features, particularly impulsiveness.
  60. ncbi Neuronal correlates of altered empathy and social cognition in borderline personality disorder
    Isabel Dziobek
    Max Planck Institute for Human Development, Lentzeallee 94, 14195 Berlin, Germany
    Neuroimage 57:539-48. 2011
    b>Borderline personality disorder (BPD) is a severe psychiatric condition of undetermined brain underpinnings, which involves profound emotion regulation deficits and interpersonal impairment...
  61. pmc Structural brain abnormalities in borderline personality disorder: a voxel-based morphometry study
    Paul Soloff
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Psychiatry Res 164:223-36. 2008
    ..tomography have contributed to our understanding of structural and functional abnormalities in borderline personality disorder (BPD); however, both methods have practical limitations to their usefulness for exploratory studies ..
  62. ncbi Amygdala-prefrontal disconnection in borderline personality disorder
    Antonia S New
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuropsychopharmacology 32:1629-40. 2007
    Abnormal fronto-amygdala circuitry has been implicated in impulsive aggression, a core symptom of borderline personality disorder (BPD)...
  63. pmc Oxytocin can hinder trust and cooperation in borderline personality disorder
    Jennifer Bartz
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1230, New York, NY 10029, USA
    Soc Cogn Affect Neurosci 6:556-63. 2011
    We investigated the effects of intranasal oxytocin (OXT) on trust and cooperation in borderline personality disorder (BPD), a disorder marked by interpersonal instability and difficulties with cooperation...
  64. ncbi The borderline diagnosis I: psychopathology, comorbidity, and personality structure
    Andrew E Skodol
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Biol Psychiatry 51:936-50. 2002
    b>Borderline personality disorder (BPD) is a complex and serious mental disorder associated with severe functional impairment, substantial treatment utilization, and a high rate of mortality by suicide...
  65. pmc Neural correlates of the use of psychological distancing to regulate responses to negative social cues: a study of patients with borderline personality disorder
    Harold W Koenigsberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10468, USA
    Biol Psychiatry 66:854-63. 2009
    Emotional instability is a defining feature of borderline personality disorder (BPD); yet, little is understood about its underlying neural correlates...
  66. ncbi omega-3 Fatty acid treatment of women with borderline personality disorder: a double-blind, placebo-controlled pilot study
    Mary C Zanarini
    Laboratory for the Study of Adult Development, McLean Hospital, Belmont, MA 02478, USA
    Am J Psychiatry 160:167-9. 2003
    The purpose of this study was to compare the efficacy of ethyl-eicosapentaenoic acid (E-EPA) and placebo in the treatment of female subjects with borderline personality disorder.
  67. pmc Attentional mechanisms of borderline personality disorder
    Michael I Posner
    Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 99:16366-70. 2002
    ..of a specific neural circuit related to self-regulation is an underlying biological deficit in borderline personality disorder (BPD)...
  68. ncbi Evidence of abnormal amygdala functioning in borderline personality disorder: a functional MRI study
    S C Herpertz
    Department of Psychiatry and Psychotherapy, Medical Faculty of Aachen Technical University-RWTH, Aachen, Germany
    Biol Psychiatry 50:292-8. 2001
    BACKGROUND: Intense and rapidly changing mood states are a major feature of borderline personality disorder (BPD); however, there have only been a few studies investigating affective processing in BPD, and in particular no ..
  69. ncbi Comparison of different strategies to decrease negative affect and increase positive affect in women with borderline personality disorder
    Gitta A Jacob
    Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Germany
    Behav Res Ther 49:68-73. 2011
    In this study we compared the effect of different emotion regulation strategies on positive and negative emotions in patients with borderline personality disorder.
  70. ncbi Neurocognitive deficits in decision-making and planning of patients with DSM-III-R borderline personality disorder
    E Bazanis
    Department of Psychiatry, University of Cambridge
    Psychol Med 32:1395-405. 2002
    Repeated, self-damaging behaviour occurring in the context of borderline personality disorder (BPD) may reflect impairments in decision-making and planning cognition...
  71. ncbi The influence of emotions on inhibitory functioning in borderline personality disorder
    Gregor Domes
    Department of Psychiatry and Psychotherapy, Rostock University, Rostock, Germany
    Psychol Med 36:1163-72. 2006
    b>Borderline personality disorder (BPD) is characterized by an emotionally unstable and impulsive cognitive and behavioral style. Inhibitory dysfunction has been hypothesized as playing a crucial role in BPD psychopathology...
  72. ncbi Olanzapine plus dialectical behavior therapy for women with high irritability who meet criteria for borderline personality disorder: a double-blind, placebo-controlled pilot study
    Marsha M Linehan
    Department of Psychology, University of Washington, Seattle 98195 1525, USA
    J Clin Psychiatry 69:999-1005. 2008
    This double-blind study examined whether olanzapine augments the efficacy of dialectical behavior therapy (DBT) in reducing anger and hostility in borderline personality disorder patients.
  73. ncbi Symptomatic overlap between attention-deficit/hyperactivity disorder and borderline personality disorder in women: the role of temperament and character traits
    Fiona E van Dijk
    Department of Psychiatry 961, Nijmegen Centre for Evidence Based Practice, Radboud University Nijmegen Medical Centre, The Netherlands
    Compr Psychiatry 53:39-47. 2012
    There is substantial symptomatic overlap between attention-deficit/hyperactivity disorder (ADHD) and borderline personality disorder (BPD) in adults, but the nature of the relationship between these disorders needs further clarification...
  74. ncbi Differential diagnosis of bipolar affective disorder type II and borderline personality disorder: analysis of the affective dimension
    Suzane Renaud
    Douglas Institute, Newman Pavillion, 6875 Boul LaSalle, Verdun, QC H4H 1R3, Canada
    Compr Psychiatry 53:952-61. 2012
    Differential diagnosis between bipolar affective disorder type II and borderline personality disorder can be problematic yet a priority for effective treatment planning...
  75. ncbi Affective instability and impulsivity in borderline personality and bipolar II disorders: similarities and differences
    C Henry
    Service Universitaire de Psychiatrie, Centre Hospitalier Charles Perrens, , 33076, Bordeaux, France
    J Psychiatr Res 35:307-12. 2001
    ..reported a high degree of comorbidity between mood disorders, among which are bipolar disorders, and borderline personality disorder and some studies have suggested that these disorders are co-transmitted in families...
  76. pmc Systems Training for Emotional Predictability and Problem Solving (STEPPS) for outpatients with borderline personality disorder: a randomized controlled trial and 1-year follow-up
    Nancee Blum
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Am J Psychiatry 165:468-78. 2008
    ..and Problem Solving (STEPPS) is a 20-week manual-based group treatment program for outpatients with borderline personality disorder that combines cognitive behavioral elements and skills training with a systems component...
  77. ncbi Borderline personality disorder and bipolar affective disorder. Spectra or spectre? A review
    Darryl Bassett
    School of Medicine, University of Notre Dame, Fremantle Australia
    Aust N Z J Psychiatry 46:327-39. 2012
    Bipolar affective disorder and borderline personality disorder have long been considered to have significant similarities and comorbidity...
  78. pmc The incremental validity of borderline personality disorder relative to major depressive disorder for suicidal ideation and deliberate self-harm in adolescents
    Carla Sharp
    Department of Psychology, University of Houston, 126 Heyne Building, Houston, TX 77024, USA
    J Pers Disord 26:927-38. 2012
    Few studies have examined the relation between suicide-related behaviors and Borderline Personality Disorder (BPD) in adolescent samples...
  79. ncbi A positron emission tomography study of memories of childhood abuse in borderline personality disorder
    Christian G Schmahl
    Department of Psychosomatic Medicine, Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 55:759-65. 2004
    b>Borderline personality disorder (BPD) is a common psychiatric disorder, which is linked to early stressors in many cases; however, the impact of traumatic events in the etiology of BPD is still unclear...
  80. ncbi Dysfunctions in understanding other minds in borderline personality disorder: a study using cartoon picture stories
    Valerie Ghiassi
    Department of Psychosomatic Medicine, University of Essen, Essen, Germany
    Psychother Res 20:657-67. 2010
    Patients with borderline personality disorder (BPD) are thought to be impaired in their ability to reflect on others' mental states...
  81. ncbi Correlation of glutamate levels in the anterior cingulate cortex with self-reported impulsivity in patients with borderline personality disorder and healthy controls
    Mareen Hoerst
    Department of Neuroimaging, Central Institute of Mental Health, Mannheim, Germany
    Arch Gen Psychiatry 67:946-54. 2010
    Dysfunction and deficits in the structure of the anterior cingulate cortex have been reported in borderline personality disorder (BPD)...
  82. ncbi Amygdala volume and depressive symptoms in patients with borderline personality disorder
    Thomas Zetzsche
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Biol Psychiatry 60:302-10. 2006
    b>Borderline personality disorder (BPD) is characterized by a high prevalence of comorbid psychiatric disorders, including major depression (MD)...
  83. ncbi Borderline personality disorder, impulsivity, and the orbitofrontal cortex
    Heather A Berlin
    Department of Experimental Psychology, University of Oxford
    Am J Psychiatry 162:2360-73. 2005
    ..Characteristics of borderline personality disorder include impulsivity and affective instability...
  84. ncbi Dialectical behaviour therapy skills training compared to standard group therapy in borderline personality disorder: a 3-month randomised controlled clinical trial
    Joaquim Soler
    Department of Psychiatry, Santa Creu i Sant Pau Hospital, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, St Antoni M Claret, 167, Barcelona 08025, Spain
    Behav Res Ther 47:353-8. 2009
    Dialectical behaviour therapy (DBT) has proven to be an effective treatment in borderline personality disorder (BPD). However, the effectiveness in BPD of DBT skills training (DBT-ST) alone is not known...
  85. ncbi Deficits in visual functions and neuropsychological inconsistency in Borderline Personality Disorder
    Thomas Beblo
    Division of Research, Evaluation and Documentation, Clinic of Psychiatry and Psychotherapy Bethel, Ev Hospital Bielefeld, Remterweg 69 71, 33617 Bielefeld, Germany
    Psychiatry Res 145:127-35. 2006
    For Borderline Personality Disorder (BPD) cognitive and perceptual impairments were reported in some but not all studies. The aim of the present study was to analyze the neuropsychological performance of BPD patients in different domains...
  86. ncbi Augmentation of antidepressants with bright light therapy in patients with comorbid depression and borderline personality disorder
    Jan Prasko
    Department of Psychiatry, University Hospital Olomouc, Czech Republic
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 154:355-61. 2010
    b>Borderline personality disorder (BPD) is typically characterized by instability and impaired behaviour, affectivity, interpersonal relations and lifestyle. The most common condition comorbid with BPD is a depressive episode...
  87. ncbi Altered emotional information processing in borderline personality disorder: an electrophysiological study
    Marlies A E Marissen
    Centre for Personality Disorders, PsyQ, The Hague, The Netherlands Erasmus University Rotterdam, Institute of Psychology, Rotterdam, The Netherlands
    Psychiatry Res 181:226-32. 2010
    Emotional dysregulation is one of the key symptoms of patients with borderline personality disorder (BPD)...
  88. ncbi EEG-vigilance differences between patients with borderline personality disorder, patients with obsessive-compulsive disorder and healthy controls
    Ulrich Hegerl
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Eur Arch Psychiatry Clin Neurosci 258:137-43. 2008
    ..with emotional instability in older studies, but has not been systematically studied in patients with borderline personality disorder (BPD)...
  89. ncbi Normal mind-reading capacity but higher response confidence in borderline personality disorder patients
    Lisa Schilling
    Department of Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Psychiatry Clin Neurosci 66:322-7. 2012
    b>Borderline personality disorder (BPD) is characterized by a pattern of instability in interpersonal relationships. Therefore, the investigation of social cognition is of compelling interest for the understanding of BPD...
  90. ncbi Serum cholesterol and leptin levels in patients with borderline personality disorder
    Murad Atmaca
    Department of Psychiatry, Firat University, School of Medicine, Elazig, Turkey
    Neuropsychobiology 45:167-71. 2002
    ..In the present study, cholesterol and leptin levels of patients with borderline personality disorder in whom impulsivity, aggressive behaviours and suicide attempts are clearly established have been ..
  91. ncbi Screening for borderline personality disorder in outpatient youth
    Andrew M Chanen
    The ORYGEN Research Centre, Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia
    J Pers Disord 22:353-64. 2008
    Young people with borderline personality disorder (BPD) commonly seek help but often go unrecognized. Screening offers a means of identifying individuals for more detailed assessment for early intervention and for research.
  92. pmc Comorbidity of borderline personality disorder and posttraumatic stress disorder in the U.S. population
    Jina Pagura
    Department of Psychology, University of Manitoba, Winnipeg, Manitoba, Canada
    J Psychiatr Res 44:1190-8. 2010
    While placed on different axes of the DSM classification system, borderline personality disorder (BPD) and posttraumatic stress disorder (PTSD) have important relationships with trauma, and overlap between these disorders has long been ..
  93. ncbi Temperament and character in patients with borderline personality disorder taking gender and comorbidity into account
    Sven Barnow
    Department of Psychiatry and Psychotherapy, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany
    Psychopathology 40:369-78. 2007
    This study examined correlations of borderline personality disorder (BPD) symptoms with scales from Cloninger's psychobiological model taking gender and psychiatric comorbidity into consideration...
  94. ncbi Interpersonal evaluation bias in borderline personality disorder
    Sven Barnow
    Department of Clinical Psychology and Psychotherapy, University of Heidelberg, Hauptstr 47 51, Heidelberg 69117, Germany
    Behav Res Ther 47:359-65. 2009
    ..hypothesizes that the emotional dysregulation and interpersonal problems in individuals with borderline personality disorder (BPD) are, at least partially, caused by dysfunctional cognitive schemas...
  95. ncbi Neuropsychobiological aspects, comorbidity patterns and dimensional models in borderline personality disorder
    Bernardo Dell'Osso
    Department of Psychiatry, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Neuropsychobiology 61:169-79. 2010
    b>Borderline personality disorder (BPD) is a comorbid and disabling condition with high prevalence in psychiatric settings...
  96. ncbi Affective instability: toward an integration of neuroscience and psychological perspectives
    Harold W Koenigsberg
    James J Peters VA Medical Center, Bronx, NY 10468, USA
    J Pers Disord 24:60-82. 2010
    ....
  97. ncbi Psychiatric diagnoses in patients previously overdiagnosed with bipolar disorder
    Mark Zimmerman
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, Rhode Island, USA
    J Clin Psychiatry 71:26-31. 2010
    ..In the present report from the MIDAS project, we examined whether there was a particular diagnostic profile associated with bipolar disorder overdiagnosis...
  98. ncbi Neural correlates of negative emotionality in borderline personality disorder: an activation-likelihood-estimation meta-analysis
    Anthony C Ruocco
    Department of Psychology, University of Toronto Scarborough, Toronto, Canada
    Biol Psychiatry 73:153-60. 2013
    Emotional vulnerabilities at the core of borderline personality disorder (BPD) involve a dysfunction of frontolimbic systems subserving negative emotionality...
  99. ncbi Autonomic impairment in borderline personality disorder: a laboratory investigation
    Anna Weinberg
    Department of Psychology, Stony Brook University, Stony Brook, NY 11794 2500, USA
    Brain Cogn 71:279-86. 2009
    ..study examines sympathetic and parasympathetic autonomic nervous system activity in individuals with Borderline Personality Disorder (BPD) before, during, and following a social stressor task...
  100. pmc Child maltreatment, attention networks, and potential precursors to borderline personality disorder
    Fred A Rogosch
    Mt Hope Family Center, University of Rochester, NY 14608, USA
    Dev Psychopathol 17:1071-89. 2005
    Potential precursors to borderline personality disorder (BPD) were investigated in a sample of 185 maltreated and 175 nonmaltreated school-aged children attending a summer camp research program...
  101. pmc Comparing impulsiveness, hostility, and depression in borderline personality disorder and bipolar II disorder
    Scott T Wilson
    Department of Neuroscience, New York State Psychiatric Institute, NY 10032, USA
    J Clin Psychiatry 68:1533-9. 2007
    To determine whether borderline personality disorder (BPD) and bipolar II disorder can be differentiated from each other and from major depressive disorder (MDD) by comparing depression severity, impulsiveness, and hostility in mood ..

Research Grants71

  1. Environmental regulation of estrogen dependent aggression
    Brian C Trainor; Fiscal Year: 2013
    ..aggression is a component of mental disorders including bipolar disorder, schizophrenia, and borderline personality disorder. Correlational and clinical trial data suggest that estrogens affect aggressive behavior in men and ..
  2. Refining Borderline Personality Disorder Using Flexible Latent Variable Modeling
    MICHAEL NELSON HALLQUIST; Fiscal Year: 2011
    DESCRIPTION (provided by candidate): Borderline Personality Disorder (BPD) is a complex psychiatric disorder associated with subjective misery, poor quality of life, and chronic suicidality, with estimates of suicide completion as high ..
  3. Exploring the Neural Circuitry of Deliberate Self Harm in Adolescents
    KATHRYN REGAN CULLEN; Fiscal Year: 2013
    ..This behavior occurs in a wide range of conditions including major depressive disorder (MDD), borderline personality disorder (BPD), anxiety disorders, substance abuse disorders, adjustment disorders and eating disorders...
  4. Course and Outcome of Bipolar Disorder in Youth
    Boris Birmaher; Fiscal Year: 2013
    ..In addition, two novel aims are proposed in this renewal. First, given overlap between BP and Borderline Personality Disorder and the risk of mistreatment that results from diagnostic error, COBY will prospectively evaluate the ..
  5. Blunted and Discordant Affect: A Transdiagnostic Construct in Psychopatholog
    Greg J Siegle; Fiscal Year: 2013
    ..Common treatments for depression, anxiety, Post-Traumatic Stress Disorder (PTSD), and Borderline personality disorder (BPD), which are typically effective for up to 40-60% of patients, work to reduce high affective ..
  6. Interpersonal Functioning and Emotion in Borderline Personality
    Paul A Pilkonis; Fiscal Year: 2013
    ..to regard attachment theory as the best framework for understanding interpersonal functioning in borderline personality disorder (BPD) In BPD, anxious, ambivalent attachment takes a distinctive form- frequent disappointments and ..
  7. Social Neuroscience of Borderline Personality Disorder
    Eric A Fertuck; Fiscal Year: 2012
    ..supports the candidate to become an expert in the social neuroscience of interpersonal reactivity in Borderline Personality Disorder (BPD)...
  8. Precursors to Borderline and Antisocial Personality Disorders in Adolescence
    Lori N Scott; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Borderline Personality Disorder (BPD) and Antisocial Personality Disorder (ASPD) are among the most serious, complex, and costly public health concerns facing the US healthcare and criminal justice ..
  9. Treating Suicidal Behavior and Self-Mutilation in BPD
    Barbara Stanley; Fiscal Year: 2012
    ..Suicidal behavior non-suicidal self-injurious behavior and depression are key problems in borderline personality disorder (BPD)...
  10. Substance Use and Risky Sex in Highly Vulnerable Populations
    Natacha Marie De Genna; Fiscal Year: 2013
    ..ongoing longitudinal study of the offspring of teenage mothers and a study of women with and without borderline personality disorder (BPD);2) collection of new data on the offspring of teenage mothers during a 16-year assessment and;3)..
  11. Assessment of Affect Instability in Adolescent Girls with BPD Features
    Diana J Whalen; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): A developmental psychopathology approach to Borderline Personality Disorder (BPD) is needed to elucidate our understanding of this complex and debilitating disorder...
  12. Aggression, Emotion, and Borderline Personality Disorder Features in Women
    Lori N Scott; Fiscal Year: 2013
    ..program that will enable the candidate to conduct innovative multi-method research on aggression and borderline personality disorder (BPD) in young women...
  13. Adolescent development of emotion regulation mechanisms
    JENNIFER ASHLEY SILVERS; Fiscal Year: 2012
    ..associated with impulse control problems, poor social functioning and psychiatric conditions such as borderline personality disorder. Adolescence is a critical time for studying emotion regulation because it is a period when 1) ..
  14. MCLEAN STUDY OF ADULT DEVELOPMENT
    Mary C Zanarini; Fiscal Year: 2013
    ..of Adult Development (MSAD), the first large-scale, prospective study of the long-term course of borderline personality disorder (BPD)...
  15. 2/2-Treatment of Suicidal and Self-Injurious Adolescents with Emotional Dysregula
    Judith A Cohen; Fiscal Year: 2013
    ..risk of suicide attempts and non-suicidal self-injuries among individuals meeting criteria for borderline personality disorder (BPD)...
  16. 1/2-Treatment of Suicidal and Self-Injurious Adolescents with Emotional Dysregula
    Marsha M Linehan; Fiscal Year: 2013
    ..risk of suicide attempts and non-suicidal self-injuries among individuals meeting criteria for borderline personality disorder (BPD)...
  17. SSRIs and Self-harm in Borderline Personality Disorder
    Michael S McCloskey; Fiscal Year: 2013
    ..Self-harm is integrally related to depressive disorders and Borderline Personality Disorder. Selective Serotonin Reuptake Inhibitors (SSRIs), like escitalopram, are front-line pharmacological ..
  18. The Effects of Intranasal Oxytocin on Social Cognitive Functioning in Adolescents
    Carolyn Ha; Fiscal Year: 2013
    ..b>Borderline Personality Disorder (BPD) is a mental illness which involves significant problems in maintaining healthy social ..
  19. Neural Substrates of Emotion Dysregulation and Self Injury
    CHRISTINA MARIE DERBIDGE; Fiscal Year: 2010
    ..factor for later suicide and psychopathology in adulthood, and may be a developmental precursor of borderline personality disorder (BPD)...
  20. The role of GRP and GRPergic circuitry in fear memory
    Gleb P Shumyatsky; Fiscal Year: 2010
    ..Moreover, GRP knockout mice can be used to study how memory of fear is involved in borderline personality disorder, PTSD and generalized anxiety disorder.
  21. Dialectical Behavior Therapy for Early Non-Responders to CBT with Binge Eating Di
    Eunice Yu Chen; Fiscal Year: 2012
    ..A case series utilizing DBT with individuals with extreme emotion dysregulation (i.e., borderline personality disorder) and BED, suggests that DBT may be useful for 'difficult-to-treat'eating disorders...
  22. Evaluating a Novel Method of Generalizing Emotion Regulation
    MARK Z ROSENTHAL; Fiscal Year: 2013
    ..g., borderline personality disorder;BPD)...
  23. PSYCHOBIOLOGY OF SUICIDAL BEHAVIOR IN BORDERLINE PERSONALITY DISORDER
    Paul H Soloff; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Psychobiology of Suicidal Behavior in Borderline Personality Disorder (BPD) is the first prospective study of clinical, psychosocial and biological risk factors for suicidal behavior in patients with ..
  24. Cognitive Control in Borderline & Trauma Psychopathology
    Charles A Sanislow; Fiscal Year: 2010
    ..magnetic resonance imaging (fMRI) to examine cognitive control mechanisms shared and unique to DSM-IV Borderline Personality Disorder (BPD) and Posttraumatic Stress Disorder (PTSD), and to identify potential differences in the neural ..
  25. MARC: Risk Mechanisms in Alcoholism and Comorbidity
    Andrew C Heath; Fiscal Year: 2013
    ..by focusing on a patient group characterized by severe affective dysregulation and impulsivity (Borderline Personality Disorder), who are known to have high risk of alcohol dependence...
  26. Developing an Emotion Regulation Group Therapy for Self-Harm Among Women with BPD
    Kim L Gratz; Fiscal Year: 2010
    ..by applicant): Deliberate self-harm is a clinically-important behavior commonly associated with borderline personality disorder (BPD)...
  27. Integrating Process and Structure in Borderline Personality Disorder
    WILLIAM W FLEESON; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Borderline Personality Disorder (BPD) is a serious mental illness, associated with severe functional impairment and significant costs to society...
  28. Ambulatory assessment of alcohol use, mood dysregulation, and alcohol craving
    Timothy J Trull; Fiscal Year: 2013
    ..by clinical significant emotional dysregulation problems (mood disorders, anxiety disorders, or borderline personality disorder) while in their natural environment...
  29. Curriculum for Training DBT Clinician-Scientists
    Marsha M Linehan; Fiscal Year: 2012
    ..DBT) is an empirically supported and integrative therapy, with established efficacy for treatment of borderline personality disorder, chronic and acute suicidality, and co-morbid substance use...
  30. An fMRI Study of the Enhancement of Emotion Regulation in Borderline Patients
    Harold W Koenigsberg; Fiscal Year: 2013
    Project Summary Borderline Personality Disorder (BPD) is a common psychiatric disorder found in approximately 2% to 6% of the population and 20% of hospitalized psychiatric patients...
  31. Neurodevelopmental Origins of Emotion Dysregulation in Borderline Personality
    MICHAEL NELSON HALLQUIST; Fiscal Year: 2013
    ..into a successful clinical neuroscience researcher investigating the neurodevelopmental basis of borderline personality disorder (BPD), particularly the role of adolescent maturation of cognitive and emotional control processes...
  32. Affective Instability and Features of Borderline Personality in Adolescent Girls
    Stephanie D Stepp; Fiscal Year: 2013
    ..the candidate to conduct research on the role of affective instability (AI) in the development of Borderline Personality Disorder (BPD) during childhood and adolescence in girls...
  33. Training executive functions;emotion regulatory and affective consequences
    Anett Gyurak; Fiscal Year: 2013
    ..g., mood and anxiety disorders) and Axis II (e.g., Borderline personality disorder) pathologies...
  34. Drug Abuse and Risky Sex in Borderline Personality
    ULRIKE NONE FESKE; Fiscal Year: 2010
    ..provided by applicant): The overarching goal of this project is to examine the association between borderline personality disorder (BPD) and a) substance use/substance use disorder and b) sexual risk taking/adverse reproductive ..
  35. DBT-ACES: Evaluation of Feasibility
    Katherine Anne Comtois; Fiscal Year: 2010
    ..year of DBT has been designed specifically for psychiatrically disabled individuals with severe borderline personality disorder to assist them to achieve recovery as recommended in the President's New Freedom Commission on ..
  36. A Cognitive Group Treatment for Borderline Outpatients
    Donald Black; Fiscal Year: 2005
    ..is to test the efficacy of a new cognitive-behavioral systems-based group treatment for persons with borderline personality disorder (BPD) and to compare it to "treatment as usual" (TAU)...
  37. Validation of a Laboratory Measure of Self-Aggression
    Michael McCloskey; Fiscal Year: 2005
    ..Participants will consist of 108 individuals with a DSM-IV Borderline Personality Disorder (BPD) and 27 psychopathology-free control participants with no past self-aggressive behavior...
  38. Neural Correlates of Emotion
    N Keele; Fiscal Year: 2003
    ..and may have important clinical implications for the treatment of psychiatric disorders involving inappropriate aggression such as bipolar disorder, borderline personality disorder or antisocial personality disorder.
  39. DIVALPROEX SODIUM/PLACEBO IN BPD
    Eric Hollander; Fiscal Year: 2000
    b>Borderline personality disorder (BPD) is a well-characterized psychiatric disorder with an estimated prevalence of 1-2 percent of the U.S. population, and high levels of impairment and mortality...
  40. Translating Research into Practice
    Perry Hoffman; Fiscal Year: 2009
    ..It may be particularly relevant for borderline personality disorder (BPD) as the personal and societal impacts of BPD, a misunderstood, misdiagnosed, under serviced ..
  41. NEUROENDOCRINOLOGY OF CHILDHOOD ABUSE IN BPD
    Robert Grossman; Fiscal Year: 2000
    Approximately 40-80 percent of borderline personality disorder (BPD) subjects have experienced childhood sexual and/or physical abuse, yet biologic sequelae of trauma has not been studied in this population...
  42. FDG PET Study of Laboratory Induced Aggression
    Antonia New; Fiscal Year: 2007
    ..provided by investigator): I am committed to understanding the neurobiological underpinnings of borderline personality disorder. This disorder causes a great deal of suffering to patients and their families...
  43. Prospective Study of Suicidal Behavior in BPD
    Barbara Stanley; Fiscal Year: 2006
    ..We will examine clinical and neurobiological factors related to suicide attempts in subjects with borderline personality disorder using a prospective design...
  44. Evaluation of Dialectical Behavior Therapy (DBT)
    M Rosenthal; Fiscal Year: 2007
    ..an opiate drug replacement) is an efficacious treatment for opiate addicts meeting criteria for Borderline Personality Disorder (BPD) and to analyze factors that influence efficacy in this population in order to improve the ..
  45. Utilizing Mobile Technology for DBT Skills Generalization with BPD-SUD Clients
    LINDA DIMEFF; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Substance use disorders (SUD) co-occurring with borderline personality disorder (BPD) pose serious and complex public health problems...
  46. Family Perspectives on Borderline Personality Disorder
    Perry Hoffman; Fiscal Year: 2007
    The objectives of the annual Family Perspectives on Borderline Personality Disorder Conferences are: 1) the dissemination of scientific information to professionals, consumers, and families for understanding the complex psychiatric ..
  47. EMOTIONAL REGULATION TREATMENT FOR BINGE EATING DISORDER
    CHRISTY TELCH; Fiscal Year: 1999
    ..Dialectical Behavior Therapy (DBT), a treatment developed for borderline personality disorder, is based in part on the theory that impulsive borderline behaviors are maladaptive attempts at ..
  48. DEVELOPMENT OF BORDERLINE PERSONALITY DISORDER FEATURES
    Timothy Trull; Fiscal Year: 2001
    b>Borderline personality disorder (BPD) is a sever personality disorder that develops in early adulthood, and is characterized by a lack of control of anger, intense and frequent mood changes, impulsive acts, disturbed interpersonal ..
  49. Mood and Reactivity in Borderline Personality Disorder
    Lori Scott; Fiscal Year: 2009
    ..to identify the specific mechanisms involved in the extreme emotional reactivity that characterizes Borderline Personality Disorder (BPD) and to apply these findings to the development and validation of both psychosocial and ..
  50. Emotional Arousal as a Predictor of Suicidal Behaviors
    STACY WELCH; Fiscal Year: 2003
    ..arousal as well as self-reported emotional arousal associated with parasuicidal behavior in borderline personality disorder are examined...
  51. Emotional-Processing in Borderline Personality Disorder
    Brett Litz; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  52. DEVELOPING FAMILY THERAPY FOR BPD DRUG ABUSING YOUTHS
    Daniel Santisteban; Fiscal Year: 1999
    ..a Stage 1 treatment development study targeting a subtype of drug abusing adolescent, those with Borderline Personality Disorder (BPD), that has proved to be particularly difficult to treat...
  53. Dispositional Affect, Family Environment, and Adolescent Suicidality
    Shirley Yen; Fiscal Year: 2009
    ..Dr. Yen seeks further training to apply her previous clinical and research experiences with adult borderline personality disorder (BPD) patients, to work with adolescents...
  54. Exposure to Shame in Borderline Personality Disorder
    SHIREEN RIZVI; Fiscal Year: 2002
    ..The study proposed here seeks to develop and test an intervention for the experience of shame in borderline personality disorder (BPD)...
  55. MHCRC FOR THE STUDY OF SUICIDAL BEHAVIOR
    JOSEPH MANN; Fiscal Year: 1999
    ..and future suicide attempts in a sample of over 340 patients with major depression, schizophrenia or borderline personality disorder. In parallel, the MHCRC has studied clinical and biological correlates of suicide in suicide victims...
  56. The DBT-SUD In-Session Response to Dysfunctional Behavior for ACT Teams
    LINDA DIMEFF; Fiscal Year: 2009
    ..and persistent mental illness (SPMI) commonly experience both Substance Use Disorders (SUDs) and Borderline Personality Disorder (BPD), resulting in serious and complex personal costs and public health problems...
  57. Borderline Personality Disorder and Interpersonal Process
    CHRISTOPHER HOPWOOD; Fiscal Year: 2006
    ..The goal of the proposed study is to extend recent research on normative interpersonal patterns to Borderline Personality Disorder (BPD)...
  58. DBT Skills Training Central
    LINDA DIMEFF; Fiscal Year: 2009
    ..an innovative, online training aid for Dialectical Behavior Therapy (DBT) skills providers treating borderline personality disorder and substance dependence (BPD-SUD) individuals...
  59. Living With Borderline Personality Disorder
    Kevin Dawkins; Fiscal Year: 2005
    ..I application proposes to test the feasibility of producing an educational video series, Living with Borderline Personality Disorder, in support of family members who have a relative diagnosed with borderline personality disorder, or ..
  60. CRF and Personality Disorder: Behavioral Correlates
    Royce Lee; Fiscal Year: 2003
    ..e. borderline personality disorder) subjects...
  61. RISK & PROTECTIVE FACTORS IN RECOVERY FROM SCHIZOPHRENIA
    JERI DOANE; Fiscal Year: 1990
    ..follows: 1) 30 young adult schizophrenia-spectrum cases; 2) 15 young adult affective disorder and/or borderline personality disorder; and 3) 15 adolescent conduct disorder and either dysthymia or borderline personality disorder...
  62. CEREBRAL 18FDG UPTAKE FOLLOWING HYDROCORTISONE IN PTSD
    Robert Grossman; Fiscal Year: 2003
    ..in research of glucocorticoid and serotonin function in post traumatic stress disorder (PTSD) and borderline personality disorder with his mentors Rachel Yehuda, Ph.D. and Larry Siever, M.D...
  63. SKILLS TRAINING VIDEO FOR DIALECTICAL BEHAVIOR THERAPY
    Jennifer Waltz; Fiscal Year: 1999
    DESCRIPTION: (adapted from applicant's abstract) Borderline personality disorder (BPD) is one of the most difficult to treat, chronic mental disorders, and is extremely costly to the mental health and medical systems...
  64. SKILLS TRAINING VIDEO FOR DIALECTICAL BEHAVIOR THERAPY
    Jennifer Waltz; Fiscal Year: 2002
    ..Behavior Therapy (DBT) is a multimodal, psychosocial treatment with demonstrated efficacy in treating borderline personality disorder (BPD). In Phase I, we developed and evaluated a pilot videotape of Marsha M. Linehan, Ph.D...
  65. Psychophysiology and Emotion Regulation in BPD
    Janice Kuo; Fiscal Year: 2005
    The proposed research tests Linehan's (1993) theory that Borderline Personality Disorder (BPD) is a disorder of pervasive emotion dysregulation...
  66. FAMILY INFLUENCES ON BORDERLINE OUTCOME
    Perry Hoffman; Fiscal Year: 2004
    ..Clinical Scientist Development Award to identify the influence of family factors on the course of borderline personality disorder (BPD) and its treatment in the community...
  67. Impulsivity and Emotion Dysregulation in BPD
    SCOTT COFFEY; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Borderline personality disorder (BPD) is a serious mental illness that adversely affects individuals, families, and society...
  68. Psychopathy and Boderline Personality in Female Inmates
    Stephanie Kendall; Fiscal Year: 2005
    The present research will investigate the relationship between Borderline Personality Disorder and psychopathy in a sample of incarcerated males and females at an adult detention center...
  69. Emotion Regulation in Teen Parasuicide and Depression
    SHEILA CROWELL; Fiscal Year: 2009
    ..marks significant risk for later suicide and may represent a precursor to the development of borderline personality disorder (BPD)...
  70. Emotional and Behavioral Dysregulation in Borderline Personality Disorder
    EDWARD SELBY; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Borderline personality disorder (BPD) is a severe disorder in which individuals often engage in extreme behaviors such as self-injury, impulsive behaviors, substance abuse and suicidal behavior...