major depressive disorder

Summary

Summary: Marked depression appearing in the involution period and characterized by hallucinations, delusions, paranoia, and agitation.

Top Publications

  1. ncbi The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R)
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    JAMA 289:3095-105. 2003
  2. ncbi Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center, Exchange Park Express, American General Tower, 6363 Forest Park Rd, Suite 1300, Dallas, TX 75390 9119, USA
    Am J Psychiatry 163:28-40. 2006
  3. ncbi The 16-Item Quick Inventory of Depressive Symptomatology (QIDS), clinician rating (QIDS-C), and self-report (QIDS-SR): a psychometric evaluation in patients with chronic major depression
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9086, USA
    Biol Psychiatry 54:573-83. 2003
  4. doi Major depressive disorder
    R H Belmaker
    Ben Gurion University of the Negev, Beersheba, Israel
    N Engl J Med 358:55-68. 2008
  5. ncbi Epidemiology of major depressive disorder: results from the National Epidemiologic Survey on Alcoholism and Related Conditions
    Deborah S Hasin
    Mailman School of Public Health, Division of Epidemiology and College of Physicians and Surgeons, Department of Psychiatry, Columbia University, New York, NY, USA
    Arch Gen Psychiatry 62:1097-106. 2005
  6. ncbi Monitoring depression treatment outcomes with the patient health questionnaire-9
    Bernd Löwe
    Department of General Internal and Psychosomatic Medicine, Heidelberg University Medical Center, D 69120 Heidelberg, Germany
    Med Care 42:1194-201. 2004
  7. pmc Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo
    P F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Mol Psychiatry 14:359-75. 2009
  8. pmc Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divide
    Jonathan Savitz
    Section on Neuroimaging in Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, National Institute of Mental Health NIH, Bethesda, MD 20892, USA
    Neurosci Biobehav Rev 33:699-771. 2009
  9. ncbi Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis
    Andrea Cipriani
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Italy Department of Psychiatry, University of Oxford, UK
    Lancet 373:746-58. 2009
  10. ncbi Placebo response in studies of major depression: variable, substantial, and growing
    B Timothy Walsh
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Dr, Unit 98, New York, NY 10032, USA
    JAMA 287:1840-7. 2002

Detail Information

Publications297 found, 100 shown here

  1. ncbi The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R)
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    JAMA 289:3095-105. 2003
    Uncertainties exist about prevalence and correlates of major depressive disorder (MDD).
  2. ncbi Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center, Exchange Park Express, American General Tower, 6363 Forest Park Rd, Suite 1300, Dallas, TX 75390 9119, USA
    Am J Psychiatry 163:28-40. 2006
    ..primary objectives in this study were to evaluate the effectiveness of citalopram, an SSRI, using measurement-based care in actual practice, and to identify predictors of symptom remission in outpatients with major depressive disorder.
  3. ncbi The 16-Item Quick Inventory of Depressive Symptomatology (QIDS), clinician rating (QIDS-C), and self-report (QIDS-SR): a psychometric evaluation in patients with chronic major depression
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9086, USA
    Biol Psychiatry 54:573-83. 2003
    ..Rating Scale for Depression (HAM-D(24)) in 596 adult outpatients treated for chronic nonpsychotic, major depressive disorder. Internal consistency was high for the QIDS-SR(16) (Cronbach's alpha =...
  4. doi Major depressive disorder
    R H Belmaker
    Ben Gurion University of the Negev, Beersheba, Israel
    N Engl J Med 358:55-68. 2008
  5. ncbi Epidemiology of major depressive disorder: results from the National Epidemiologic Survey on Alcoholism and Related Conditions
    Deborah S Hasin
    Mailman School of Public Health, Division of Epidemiology and College of Physicians and Surgeons, Department of Psychiatry, Columbia University, New York, NY, USA
    Arch Gen Psychiatry 62:1097-106. 2005
    ..representative data on 12-month and lifetime prevalence, correlates, and comorbidity of DSM-IV major depressive disorder (MDD) among adults in the United States...
  6. ncbi Monitoring depression treatment outcomes with the patient health questionnaire-9
    Bernd Löwe
    Department of General Internal and Psychosomatic Medicine, Heidelberg University Medical Center, D 69120 Heidelberg, Germany
    Med Care 42:1194-201. 2004
    ..We investigated responsiveness to treatment, reproducibility, and minimal clinically important difference of the Patient Health Questionnaire-9 (PHQ-9), a standard instrument for diagnosing depression in primary care...
  7. pmc Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo
    P F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Mol Psychiatry 14:359-75. 2009
    b>Major depressive disorder (MDD) is a common complex trait with enormous public health significance...
  8. pmc Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divide
    Jonathan Savitz
    Section on Neuroimaging in Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, National Institute of Mental Health NIH, Bethesda, MD 20892, USA
    Neurosci Biobehav Rev 33:699-771. 2009
    Both major depressive disorder and bipolar disorder are the subject of a voluminous imaging and genetics literature...
  9. ncbi Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis
    Andrea Cipriani
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Italy Department of Psychiatry, University of Oxford, UK
    Lancet 373:746-58. 2009
    ..We therefore did a multiple-treatments meta-analysis, which accounts for both direct and indirect comparisons, to assess the effects of 12 new-generation antidepressants on major depression...
  10. ncbi Placebo response in studies of major depression: variable, substantial, and growing
    B Timothy Walsh
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Dr, Unit 98, New York, NY 10032, USA
    JAMA 287:1840-7. 2002
    ..Intense debate persists about the need for placebo-controlled groups in clinical trials of medications for major depressive disorder (MDD)...
  11. pmc Imaging phenotypes of major depressive disorder: genetic correlates
    J B Savitz
    Mood and Anxiety Disorders Program, NIH NIMH, Bethesda, MD 20892, USA
    Neuroscience 164:300-30. 2009
    ..of identifying phenotypes that are associated with, or are indicative of, a vulnerability to developing major depressive disorder (MDD)...
  12. ncbi Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9086, USA
    Am J Psychiatry 163:1905-17. 2006
    ..This report describes the participants and compares the acute and longer-term treatment outcomes associated with each of four successive steps in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial...
  13. ncbi Deep brain stimulation for treatment-resistant depression
    Helen S Mayberg
    Rotman Research Institute at Baycrest Centre, and Departments of Psychiatry and Neurology, University of Toronto, Toronto, Ontario, M6A 2E1, Canada
    Neuron 45:651-60. 2005
    ....
  14. ncbi Prevalence and incidence studies of mood disorders: a systematic review of the literature
    Paul Waraich
    Mental Health Evaluation and Community Consultation Unit, University of British Columbia, Vancouver
    Can J Psychiatry 49:124-38. 2004
    ....
  15. ncbi Emerging role of glutamate in the pathophysiology of major depressive disorder
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba 260 8670, Japan
    Brain Res Rev 61:105-23. 2009
    b>Major depressive disorder (MDD) is a common, chronic, recurrent mental illness that affects millions of individuals worldwide...
  16. ncbi Structural brain abnormalities in major depressive disorder: a selective review of recent MRI studies
    Valentina Lorenzetti
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, Australia
    J Affect Disord 117:1-17. 2009
    While there is evidence to suggest that major depressive disorder (MDD) is associated with structural brain abnormalities, the precise nature of these abnormalities remains unclear.
  17. ncbi Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
    C M Pariante
    Section of Clinical Neuropharmacology, Institute of Psychiatry, King's College London, London, United Kingdom
    Biol Psychiatry 49:391-404. 2001
    ..Further elucidation of the biochemical and molecular mechanisms involved in GR changes in major depression is an exciting frontier that will no doubt lead to new insights into the pathophysiology and treatment of affective disorders...
  18. ncbi Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity
    M Verhagen
    Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mol Psychiatry 15:260-71. 2010
    ..genetic association studies of the BDNF Val66Met polymorphism (single nucleotide polymorphism rs6265) in major depressive disorder (MDD) have produced inconsistent results...
  19. ncbi Major depressive disorder and hypothalamic-pituitary-adrenal axis activity: results from a large cohort study
    Sophie A Vreeburg
    Department of Psychiatry, VU University Medical Center, A J Ernststraat 887, 1081 HL Amsterdam, The Netherlands
    Arch Gen Psychiatry 66:617-26. 2009
    ..There is a central belief that depression is associated with hyperactivity of the hypothalamic-pituitary-adrenal axis, resulting in higher cortisol levels. However, results are inconsistent...
  20. ncbi Measuring depression outcome with a brief self-report instrument: sensitivity to change of the Patient Health Questionnaire (PHQ-9)
    Bernd Löwe
    Department of General Internal and Psychosomatic Medicine, University of Heidelberg, Medical Hospital, Germany
    J Affect Disord 81:61-6. 2004
    ..Therefore, we investigated the sensitivity to change of the PHQ-9 in three groups of patients whose depression status either improved, remained unchanged, or deteriorated over time...
  21. pmc Cascading effects of stressors and inflammatory immune system activation: implications for major depressive disorder
    Hymie Anisman
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    J Psychiatry Neurosci 34:4-20. 2009
    ..of the depressogenic actions of these cytokines in rodent models and in humans, and I provide provisional suggestions (and caveats) about the mechanisms by which cytokines and stressors might culminate in major depressive disorder.
  22. ncbi Transcriptional profiling reveals evidence for signaling and oligodendroglial abnormalities in the temporal cortex from patients with major depressive disorder
    C Aston
    Neuroscience Discovery Research, Wyeth Research, Princeton, NJ, USA
    Mol Psychiatry 10:309-22. 2005
    b>Major depressive disorder is one of the most common and devastating psychiatric disorders...
  23. pmc 5-HT(1A) receptor function in major depressive disorder
    Jonathan Savitz
    Section on Neuroimaging in Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, NIH NIMH, Bethesda, MD 20892, United States
    Prog Neurobiol 88:17-31. 2009
    Dysfunction of the serotonin 1A receptor (5-HT(1A)) may play a role in the genesis of major depressive disorder (MDD)...
  24. pmc Reduced hedonic capacity in major depressive disorder: evidence from a probabilistic reward task
    Diego A Pizzagalli
    Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
    J Psychiatr Res 43:76-87. 2008
    ..The goal of the present study was to test the hypothesis that individuals with major depression are characterized by blunted reward responsiveness, particularly when anhedonic symptoms are prominent...
  25. ncbi Atypical antipsychotic augmentation in major depressive disorder: a meta-analysis of placebo-controlled randomized trials
    J Craig Nelson
    Department of Psychiatry, University of California San Francisco, 401 Parnassus Ave, Box 0984 F, San Francisco, CA 94143, USA
    Am J Psychiatry 166:980-91. 2009
    The authors sought to determine by meta-analysis the efficacy and tolerability of adjunctive atypical antipsychotic agents in major depressive disorder.
  26. pmc A genomewide association study of citalopram response in major depressive disorder
    Holly A Garriock
    Department of Psychiatry and Institute for Human Genetics, University of California, San Francisco, San Francisco, CA 94143 0984, USA
    Biol Psychiatry 67:133-8. 2010
    ..We have carried out a genomewide association study to determine whether common DNA variation influences antidepressant response...
  27. ncbi Brain volume abnormalities in major depressive disorder: a meta-analysis of magnetic resonance imaging studies
    P Cédric M P Koolschijn
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Hum Brain Mapp 30:3719-35. 2009
    ..In this comprehensive meta-analysis the magnitude and extent of brain volume differences between 2,418 patients with major depressive disorder and 1,974 healthy individuals from 64 studies was determined.
  28. ncbi Increased self-focus in major depressive disorder is related to neural abnormalities in subcortical-cortical midline structures
    Simone Grimm
    Department of Psychiatry, University of Zurich, Zurich, Switzerland
    Hum Brain Mapp 30:2617-27. 2009
    Patients with major depressive disorder (MDD) often show a tendency to strongly introspect and reflect upon their self, which has been described as increased self-focus...
  29. ncbi Psychological distress, major depressive disorder, and risk of stroke
    P G Surtees
    Strangeways Research Laboratory, University of Cambridge, Department of Public Health and Primary Care, Cambridge, CB1 8RN, UK
    Neurology 70:788-94. 2008
    ..We investigated this association based upon a large population-based prospective cohort study...
  30. ncbi A meta-analysis of emotional reactivity in major depressive disorder
    Lauren M Bylsma
    Department of Psychology, University of South Florida, Tampa, FL 33620, USA
    Clin Psychol Rev 28:676-91. 2008
    Three alternative views regarding how Major Depressive Disorder (MDD) alters emotional reactivity have been featured in the literature: positive attenuation (reduced positive reactivity), negative potentiation (increased negative ..
  31. ncbi Neurocognitive deficits and disability in major depressive disorder
    Judith Jaeger
    Center for Neuropsychiatric Outcome and Rehabilitation Research, Zucker Hillside Hospital, North Shore Long Island Jewish Health System, 75 59 263rd St, Glen Oaks, NY 11004, USA
    Psychiatry Res 145:39-48. 2006
    Disability in life functioning is an important and poorly understood consequence of major depressive disorder (MDD). Mood symptoms do not account for the magnitude of disability resulting from MDD...
  32. pmc Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder
    Diego A Pizzagalli
    Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland St, Cambridge, MA 02138, USA
    Am J Psychiatry 166:702-10. 2009
    b>Major depressive disorder is characterized by impaired reward processing, possibly due to dysfunction in the basal ganglia...
  33. pmc Relationship between amygdala responses to masked faces and mood state and treatment in major depressive disorder
    Teresa A Victor
    National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Arch Gen Psychiatry 67:1128-38. 2010
    b>Major depressive disorder (MDD) is associated with behavioral and neurophysiological evidence of mood-congruent processing biases toward explicitly presented, emotionally valenced stimuli...
  34. ncbi Abnormal size of the amygdala predicts impaired emotional memory in major depressive disorder
    Godehard Weniger
    Department of Psychiatry and Psychotherapy, University of Gottingen, Von Siebold Str 5, D 37075 Gottingen, FRG, Germany
    J Affect Disord 94:219-29. 2006
    Amygdala and hippocampus show significant structural abnormalities in major depressive disorder (MDD). Individuals with MDD have difficulties in emotional memory...
  35. pmc Major depressive disorder with subthreshold bipolarity in the National Comorbidity Survey Replication
    Jules Angst
    Department of Psychiatry, Zurich University Psychiatric Hospital, Zurich, Switzerland
    Am J Psychiatry 167:1194-201. 2010
    There is growing clinical and epidemiologic evidence that major mood disorders form a spectrum from major depressive disorder to pure mania...
  36. ncbi The stanley foundation brain collection and neuropathology consortium
    E F Torrey
    Stanley Foundation Research Programs, 5430 Grosvenor Lane, Suite 200, Bethesda, MD 20814, USA
    Schizophr Res 44:151-5. 2000
    ..from the collection, well-matched groups of 15 each with diagnoses of schizophrenia, bipolar disorder, major depressive disorder without psychotic features, and normal controls...
  37. ncbi Chronic pain and major depressive disorder in the general population
    Maurice M Ohayon
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, CA 94303, USA
    J Psychiatr Res 44:454-61. 2010
    This study aims (1) to assess the prevalence of Chronic Painful Physical Condition (CPPC) and major depressive disorder (MDD) in the general population; (2) to evaluate their interaction and co-morbidity with sleep and organic disorders; ..
  38. ncbi A differential pattern of neural response toward sad versus happy facial expressions in major depressive disorder
    Simon Surguladze
    Institute of Psychiatry, King s College London, London
    Biol Psychiatry 57:201-9. 2005
    ..In depressed individuals, implicit and explicit attentional biases away from happy and toward sad stimuli have been demonstrated. These may be associated with the negative cognitions in these individuals...
  39. ncbi Diagnosis and definition of treatment-resistant depression
    Maurizio Fava
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Psychiatry 53:649-59. 2003
    ..It is apparent that there may be varying degrees of treatment resistance. Some staging methods to assess levels of treatment resistance in depression are being developed, but need to be tested empirically...
  40. ncbi The loudness dependence of the auditory evoked potential (LDAEP) in schizophrenia, bipolar disorder, major depressive disorder, anxiety disorder, and healthy controls
    Young Min Park
    Department of Psychiatry, Inje University, Ilsan Paik Hospital, 2240 Daehwa dong, Ilsanseo gu, Goyang 411 706, South Korea
    Prog Neuropsychopharmacol Biol Psychiatry 34:313-6. 2010
    Serotonergic dysfunction in schizophrenia, bipolar disorder, major depressive disorder, anxiety disorder, and healthy controls was evaluated by measuring the activity of the loudness dependence of the auditory evoked potential (LDAEP).
  41. ncbi Imbalance between left and right dorsolateral prefrontal cortex in major depression is linked to negative emotional judgment: an fMRI study in severe major depressive disorder
    Simone Grimm
    Department of Psychiatry, University of Zurich, Switzerland
    Biol Psychiatry 63:369-76. 2008
    ..TMS) studies suggest imbalance between left and right dorsolateral prefrontal cortex (DLPFC) in major depressive disorder (MDD) the fundamental neuropsychological characterization of left DLPFC hypoactivity and right DLPFC ..
  42. ncbi White matter abnormalities in first-episode, treatment-naive young adults with major depressive disorder
    Ning Ma
    Mental Health Institute, Department of Radiology, Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China
    Am J Psychiatry 164:823-6. 2007
    The aim of this study was to explore the microstructural integrity of whole-brain white matter by diffusion tensor imaging in first-episode, treatment-naive young adults with major depressive disorder.
  43. ncbi Effect of interventions for major depressive disorder and significant depressive symptoms in patients with diabetes mellitus: a systematic review and meta-analysis
    Christina M van der Feltz-Cornelis
    Research Program for Diagnosis and Treatment of Mental Disorder, Trimbos Instituut Netherlands Institute of Mental Health and Addiction, Utrecht, The Netherlands
    Gen Hosp Psychiatry 32:380-95. 2010
    ..Comorbid depression in diabetes is highly prevalent, negatively impacting well-being and diabetes control. How depression in diabetes is best treated is unknown...
  44. ncbi Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [11C]DASB; comparison with bipolar disorder
    Dara M Cannon
    Molecular Imaging Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Biol Psychiatry 62:870-7. 2007
    ....
  45. ncbi Efficacy of the novel antidepressant agomelatine on the circadian rest-activity cycle and depressive and anxiety symptoms in patients with major depressive disorder: a randomized, double-blind comparison with sertraline
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University Vienna, MUV, AKH, Wahringer Gurtel 18 20, A 1090 Wien, Austria
    J Clin Psychiatry 71:109-20. 2010
    ..at MT(1)/MT(2) receptors and an antagonist at 5-HT(2C) receptors, versus sertraline with regard to the amplitude of the circadian rest-activity cycle and depressive and anxiety symptoms in patients with major depressive disorder (MDD).
  46. pmc Exercise and pharmacotherapy in the treatment of major depressive disorder
    James A Blumenthal
    Department of Psychiatry and Behavioral Sciences, Box 3119, Duke University Medical Center, Durham, NC, USA
    Psychosom Med 69:587-96. 2007
    ....
  47. ncbi Bupropion-SR, sertraline, or venlafaxine-XR after failure of SSRIs for depression
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9086, USA
    N Engl J Med 354:1231-42. 2006
    ..After unsuccessful treatment for depression with a selective serotonin-reuptake inhibitor (SSRI), it is not known whether switching to one antidepressant is more effective than switching to another...
  48. ncbi Daily left prefrontal transcranial magnetic stimulation therapy for major depressive disorder: a sham-controlled randomized trial
    Mark S George
    Brain Stimulation Division, Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA
    Arch Gen Psychiatry 67:507-16. 2010
    ..Daily left prefrontal repetitive transcranial magnetic stimulation (rTMS) has been studied as a potential treatment for depression, but previous work had mixed outcomes and did not adequately mask sham conditions...
  49. ncbi Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts
    P Muglia
    Genetics Division, Drug Discovery, GlaxoSmithKline R and D, Verona, Italy
    Mol Psychiatry 15:589-601. 2010
    b>Major depressive disorder (MDD) is a highly prevalent disorder with substantial heritability. Heritability has been shown to be substantial and higher in the variant of MDD characterized by recurrent episodes of depression...
  50. ncbi Mindfulness-based cognitive therapy for depression: replication and exploration of differential relapse prevention effects
    S Helen Ma
    Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, United Kingdom
    J Consult Clin Psychol 72:31-40. 2004
    ..MBCT is an effective and efficient way to prevent relapse/recurrence in recovered depressed patients with 3 or more previous episodes...
  51. pmc Screening for depression in medical settings with the Patient Health Questionnaire (PHQ): a diagnostic meta-analysis
    Simon Gilbody
    Department of Health Sciences, University of York, York, YO10 5DD, UK
    J Gen Intern Med 22:1596-602. 2007
    ..To summarize the psychometric properties of the PHQ2 and PHQ9 as screening instruments for depression...
  52. ncbi Clinical and health services relationships between major depression, depressive symptoms, and general medical illness
    Wayne J Katon
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Biol Psychiatry 54:216-26. 2003
    ..e., decreased heart rate variability, increased adhesiveness of platelets) may explain this association with increased morbidity and mortality...
  53. ncbi Meta-analyses of genetic studies on major depressive disorder
    S Lopez-Leon
    Genetic Epidemiology Unit, Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Mol Psychiatry 13:772-85. 2008
    The genetic basis of major depressive disorder (MDD) has been investigated extensively, but the identification of MDD genes has been hampered by conflicting results from underpowered studies...
  54. ncbi Fluoxetine, cognitive-behavioral therapy, and their combination for adolescents with depression: Treatment for Adolescents With Depression Study (TADS) randomized controlled trial
    John March
    Duke Clinical Research Institute, Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    JAMA 292:807-20. 2004
    Initial treatment of major depressive disorder in adolescents may include cognitive-behavioral therapy (CBT) or a selective serotonin reuptake inhibitor (SSRI). However, little is known about their relative or combined effectiveness.
  55. pmc Core symptoms of major depressive disorder: relevance to diagnosis and treatment
    Sidney H Kennedy
    Department of Psychiatry, University Health Network, University of Toronto, Ontario, Canada
    Dialogues Clin Neurosci 10:271-7. 2008
    The construct of major depressive disorder makes no etiological assumptions about populations with diverse symptom clusters...
  56. ncbi Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder
    M Kato
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Mol Psychiatry 15:473-500. 2010
    ..This would have required a Bonferroni significance level of P<0.0023. Although some heterogeneity was present across studies, our finding suggests that 5-HTTLPR, STin2, HTR1A, HTR2A, TPH1 and BDNF may modulate antidepressant response...
  57. ncbi Associations between serum lipids and major depressive disorder: results from the Netherlands Study of Depression and Anxiety (NESDA)
    Arianne K B van Reedt Dortland
    Leiden University Medical Centre, Department of Psychiatry, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Psychiatry 71:729-36. 2010
    ..However, previous studies did not always take into consideration potentially mediating factors or heterogeneity of symptoms, which may clarify contradicting findings...
  58. pmc Structural changes in the hippocampus in major depressive disorder: contributions of disease and treatment
    Nikolai V Malykhin
    Department of Psychiatry, and Centre for Neuroscience, University of Alberta, Edmonton, Alta
    J Psychiatry Neurosci 35:337-43. 2010
    Previous magnetic resonance imaging (MRI) studies of patients with major depressive disorder (MDD) have consistently shown bilateral and unilateral reductions in hippocampal volume relative to healthy controls...
  59. ncbi A prospective study of the incidence and open-label treatment of interferon-induced major depressive disorder in patients with hepatitis C
    P Hauser
    Portland VA Medical Center, Behavioral Health and Neurosciences Division, NW Hepatitis C Field Based Resource Center Oregon Health and Sciences University, Portland, OR 97201, USA
    Mol Psychiatry 7:942-7. 2002
    Interferon (IFN) therapy has been associated with the development of Major Depressive Disorder (MDD) when given to patients with hepatitis C (HCV)...
  60. ncbi Pro-inflammatory cytokines and treatment response to escitalopram in major depressive disorder
    Triin Eller
    Department of Psychiatry, University of Tartu, Estonia
    Prog Neuropsychopharmacol Biol Psychiatry 32:445-50. 2008
    ..Our data indicated that a higher level of TNF-alpha might predict a non-response to treatment with escitalopram and that changes in concentrations of sIL-2R during the treatment were different in responders and non-responders...
  61. ncbi Incidence and predictors of suicide attempts in DSM-IV major depressive disorder: a five-year prospective study
    K Mikael Holma
    Mood, Depression, and Suicidal Behavior Unit, National Institute for Health and Welfare, Helsinki, Finland
    Am J Psychiatry 167:801-8. 2010
    Prospective long-term studies of risk factors for suicide attempts among patients with major depressive disorder have not investigated the course of illness and state at the time of the act...
  62. ncbi Breakdown of long-range temporal correlations in theta oscillations in patients with major depressive disorder
    Klaus Linkenkaer-Hansen
    BioMag Laboratory, Engineering Centre, Helsinki University Central Hospital, FIN 00029 HUS, Finland
    J Neurosci 25:10131-7. 2005
    ..This baseline state has been shown to differ in major depressive disorder. More recently, several studies have documented that despite having a complex temporal structure, ..
  63. ncbi Differential prediction of first clinical response to serotonergic and noradrenergic antidepressants using the loudness dependence of auditory evoked potentials in patients with major depressive disorder
    Georg Juckel
    Department of Psychiatry, Ruhr University Bochum, Bochum, Germany
    J Clin Psychiatry 68:1206-12. 2007
    ..The aim of the current randomized prospective study was to investigate whether or not LDAEP also allows the differential prediction of treatment response to serotonergic versus noradrenergic antidepressants...
  64. pmc Rapid onset of antidepressant action: a new paradigm in the research and treatment of major depressive disorder
    Rodrigo Machado-Vieira
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Department of Health and Human Services, Bethesda, MD 20892 1282, USA
    J Clin Psychiatry 69:946-58. 2008
    ..This article reviews the published data related to different aspects of rapid improvement of depressive symptoms...
  65. ncbi Evidence of cortical inhibitory deficits in major depressive disorder
    Andrea J Levinson
    Centre for Addiction and Mental Health, University of Toronto, Toronto, ON ONM5T 1R8, Canada
    Biol Psychiatry 67:458-64. 2010
    Several lines of evidence suggest that major depressive disorder is associated with deficits in gamma-aminobutyric acid (GABA) inhibitory neurotransmission...
  66. ncbi Association between major depressive disorder and a functional polymorphism of the 5-hydroxytryptamine (serotonin) transporter gene: a meta-analysis
    Chikako Kiyohara
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Psychiatr Genet 20:49-58. 2010
    ..Despite strong biological plausibility, the relationship between 5-HTTLPR and the risk of major depressive disorder (MDD) is unclear...
  67. pmc Alterations of white matter integrity in adults with major depressive disorder: a magnetic resonance imaging study
    Ke Zou
    Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China
    J Psychiatry Neurosci 33:525-30. 2008
    The purpose of our study was to investigate alterations of white matter integrity in adults with major depressive disorder (MDD) using magnetic resonance imaging (MRI).
  68. ncbi Deep TMS in a resistant major depressive disorder: a brief report
    O Rosenberg
    Beer Yaaakov Mental Health Center, Sackler School of Medicine University of Tel Aviv Israel, Israel
    Depress Anxiety 27:465-9. 2010
    ..Repetitive transcranial magnetic stimulation (rTMS) has proven effective. Recently, a greater intracranial penetration coil has been developed. We tested the efficacy of the coil in the treatment of resistant major depression...
  69. ncbi Combination of antidepressant medications from treatment initiation for major depressive disorder: a double-blind randomized study
    Pierre Blier
    University of Ottawa Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada K1Z 7K4
    Am J Psychiatry 167:281-8. 2010
    Various classes of antidepressant medications generally induce remission of major depressive disorder in only about one-third of patients...
  70. ncbi The combined effects of the 5-HTTLPR and 5-HTR1A genes modulates the relationship between negative life events and major depressive disorder in a Chinese population
    Kerang Zhang
    Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, 030001, PR China
    J Affect Disord 114:224-31. 2009
    ..The aim of this study is to analyze the combined effect of four serotonin-related genes and two environmental factors on MDD in a Chinese population...
  71. ncbi Cloninger's temperament and character dimensions of personality in patients with major depressive disorder
    Feryal Cam Celikel
    Department of Psychiatry, Gaziosmanpasa University School of Medicine, 60100 Tokat, Turkey
    Compr Psychiatry 50:556-61. 2009
    ..dimensional psychobiologic model of personality and depression in an outpatient population with major depressive disorder. Eighty-one depressed outpatients (67 women, 14 men) and 51 healthy controls (35 women, 16 men) filled ..
  72. ncbi Exploring the correlates of suicide attempts among individuals with major depressive disorder: findings from the national epidemiologic survey on alcohol and related conditions
    James M Bolton
    Department of Psychiatry, University of Manitoba, Winnipeg, Manitoba, Canada
    J Clin Psychiatry 69:1139-49. 2008
    There are no previous studies describing the correlates of suicide attempts in individuals with major depressive disorder in a nationally representative sample...
  73. ncbi The Inventory of Depressive Symptomatology, Clinician Rating (IDS-C) and Self-Report (IDS-SR), and the Quick Inventory of Depressive Symptomatology, Clinician Rating (QIDS-C) and Self-Report (QIDS-SR) in public sector patients with mood disorders: a psych
    M H Trivedi
    Department of Psychiatry and Academic Computing Services, University of Texas, Southwestern Medical Center at Dallas 75235, USA
    Psychol Med 34:73-82. 2004
    ..Both the IDS and QIDS are available in matched clinician-rated (IDS-C30; QIDS-C16) and self-report (IDS-SR30; QIDS-SR16) formats...
  74. ncbi The relationship between quality of interpersonal relationships and major depressive disorder: findings from the National Comorbidity Survey
    C Zlotnick
    Butler Hospital Brown University, Department of Psychiatry and Human Behaviour, 345 Blackstone Boulevard, Providence, RI 02906, USA
    J Affect Disord 59:205-15. 2000
    The current study compared the quality of interpersonal relationships in individuals with major depressive disorder to individuals with dysthymia, comorbid depression, nonaffective disorders, and no psychiatric disorders.
  75. ncbi Th2 cytokine response in Major Depressive Disorder patients before treatment
    Lenin Pavon
    Department of Psychoimmunology, National Institute of Psychiatry Ramon de la Fuente, Mexico
    J Neuroimmunol 172:156-65. 2006
    In Major Depressive Disorder (MDD), the neuroendocrine and immune systems interactions are impaired. We investigated the pro/anti-inflammatory Th1/Th2 cytokine balance in MDD patients and in non-depressed control group...
  76. ncbi Rumination and overgeneral memory in depression: effects of self-focus and analytic thinking
    E Watkins
    Department of Psychology, Institute of Psychiatry, King s College, London, United Kingdom
    J Abnorm Psychol 110:353-7. 2001
    ..Overgeneral memory in depression may be associated with chronic ruminative attempts to make sense of current or past difficulties...
  77. ncbi Heterogeneity of DSM-IV major depressive disorder as a consequence of subthreshold bipolarity
    Petra Zimmermann
    Molecular Psychology Unit, Max Planck Institute of Psychiatry, Kraepelinstrasse 2, 80804 Munich, Germany
    Arch Gen Psychiatry 66:1341-52. 2009
    There is growing evidence that major depressive disorder (MDD) might be overdiagnosed at the expense of bipolar disorder (BPD).
  78. ncbi P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder
    Susanne Lucae
    The Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Hum Mol Genet 15:2438-45. 2006
    ..the P2RX7 gene and adjacent genes in a sample of 1000 German Caucasian patients suffering from recurrent major depressive disorder (MDD). These were contrasted with diagnosed healthy Caucasian controls from the same population (n=1029)...
  79. pmc fMRI of alterations in reward selection, anticipation, and feedback in major depressive disorder
    Moria J Smoski
    Department of Psychiatry, Duke University Medical Center, Durham, NC, 27710, USA
    J Affect Disord 118:69-78. 2009
    The purpose of the present investigation was to evaluate reward processing in unipolar major depressive disorder (MDD)...
  80. ncbi Prevalence and predictors of recurrence of major depressive disorder in the adult population
    F Hardeveld
    De Gelderse Roos, Institute for Mental Health Care, Ede, The Netherlands
    Acta Psychiatr Scand 122:184-91. 2010
    Knowledge of the risk of recurrence after recovery of a major depressive disorder (MDD) is of clinical and scientific importance...
  81. pmc Cognitive behavioral therapy for insomnia enhances depression outcome in patients with comorbid major depressive disorder and insomnia
    Rachel Manber
    Department of Psychiatry and Behavioral Sciences, Stanford University, 401 Quarry Rd, Stanford, CA 94305, USA
    Sleep 31:489-95. 2008
    Insomnia impacts the course of major depressive disorder (MDD), hinders response to treatment, and increases risk for depressive relapse...
  82. ncbi Striatal ionotropic glutamate receptor expression in schizophrenia, bipolar disorder, and major depressive disorder
    J H Meador-Woodruff
    Mental Health Research Institute and Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109 0720, USA
    Brain Res Bull 55:631-40. 2001
    ....
  83. ncbi Molecular studies of major depressive disorder: the epigenetic perspective
    J Mill
    The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Mol Psychiatry 12:799-814. 2007
    b>Major depressive disorder (MDD) is a common and highly heterogeneous psychiatric disorder encompassing a spectrum of symptoms involving deficits to a range of cognitive, psychomotor and emotional processes...
  84. ncbi The role of IL-12 and TGF-beta1 in the pathophysiology of major depressive disorder
    Kyung Min Lee
    Department of Psychiatry, Korea University College of Medicine, Ansan Hospital, Go Jan Dong, Ansan City, Kyunggi Province, Seoul 425 070, South Korea
    Int Immunopharmacol 6:1298-304. 2006
    ..IL-12 and TGF-beta1, which represent the cytokines of the Th1 and Th3 types, in the pathophysiology of major depressive disorder (MDD)...
  85. ncbi The neural correlates of anhedonia in major depressive disorder
    Paul A Keedwell
    Section of Neuroscience and Emotion, Department of Psychological Medicine, Institute of Psychiatry, DeCrespigny Park, London, United Kingdom
    Biol Psychiatry 58:843-53. 2005
    ..It is an important diagnostic feature of major depressive disorder (MDD), and predicts antidepressant efficacy...
  86. ncbi Suicidal ideation and attempts among psychiatric patients with major depressive disorder
    T Petteri Sokero
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    J Clin Psychiatry 64:1094-100. 2003
    Few studies have investigated risk factors for suicidal ideation and attempts, or possible variations in them, among representative samples of psychiatric patients with major depressive disorder.
  87. pmc Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arch Gen Psychiatry 62:617-27. 2005
    ..Little is known about the general population prevalence or severity of DSM-IV mental disorders...
  88. ncbi Genome-wide association of major depression: description of samples for the GAIN Major Depressive Disorder Study: NTR and NESDA biobank projects
    Dorret I Boomsma
    Netherlands Twin Register, Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands
    Eur J Hum Genet 16:335-42. 2008
    To identify the genomic regions that confer risk and protection for major depressive disorder (MDD) in humans, large-scale studies are needed...
  89. pmc Mitochondrial variants in schizophrenia, bipolar disorder, and major depressive disorder
    Brandi Rollins
    Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 4:e4913. 2009
    ..phosphorylation have been reported in individuals with schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD) in transcriptomic, proteomic, and metabolomic studies...
  90. ncbi Residual symptoms after remission of major depressive disorder with citalopram and risk of relapse: a STAR*D report
    A A Nierenberg
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Psychol Med 40:41-50. 2010
    Many patients with major depressive disorder (MDD) who experience full symptomatic remission after antidepressant treatment still have residual depressive symptoms...
  91. pmc Association of major depressive disorder with altered functional brain response during anticipation and processing of heat pain
    Irina A Strigo
    Department of Psychiatry, University of California San Diego, 3350 La Jolla Village Dr, Bldg 13, MC 9151 B, La Jolla, CA 92161, USA
    Arch Gen Psychiatry 65:1275-84. 2008
    Chronic pain and depression are highly comorbid conditions, yet little is known about the neurobiological basis of pain processing in major depressive disorder (MDD).
  92. pmc Amygdala volume in major depressive disorder: a meta-analysis of magnetic resonance imaging studies
    J P Hamilton
    Department of Psychology, Stanford University, Stanford, CA 94305, USA
    Mol Psychiatry 13:993-1000. 2008
    b>Major depressive disorder has been associated with volumetric abnormality in the amygdala...
  93. ncbi Clinical response and risk for reported suicidal ideation and suicide attempts in pediatric antidepressant treatment: a meta-analysis of randomized controlled trials
    Jeffrey A Bridge
    Department of Pediatrics and Columbus Children s Research Institute, The Ohio State University, Columbus, USA
    JAMA 297:1683-96. 2007
    ..The US Food and Drug Administration (FDA) has issued warnings that use of antidepressant medications poses a small but significantly increased risk of suicidal ideation/suicide attempt for children and adolescents...
  94. pmc A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder
    Margaret C McKinnon
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Psychiatry Neurosci 34:41-54. 2009
    Some, although not all, studies report small hippocampal volume in patients with major depressive disorder (MDD) relative to healthy controls. Here, we explore the contribution of key demographic and clinical variables to this difference.
  95. ncbi A prospective investigation of major depressive disorder and comorbidity in abused and neglected children grown up
    Cathy Spatz Widom
    Department of Psychiatry, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 183 S Orange Avenue, Newark, NJ 07103, USA
    Arch Gen Psychiatry 64:49-56. 2007
    ..Few prospective longitudinal studies have examined the relationship between abuse or neglect in childhood and depression in adulthood...
  96. ncbi Validation of hippocampal volumes measured using a manual method and two automated methods (FreeSurfer and IBASPM) in chronic major depressive disorder
    Woo Suk Tae
    Neuroscience Research Institute, Kangwon National University College of Medicine, Kangwon, Korea
    Neuroradiology 50:569-81. 2008
    ..To validate the usefulness of the packages available for automated hippocampal volumetry, we measured hippocampal volumes using one manual and two recently developed automated volumetric methods...
  97. ncbi Cytokine imbalance in the pathophysiology of major depressive disorder
    Yong Ku Kim
    Department of Psychiatry, Korea University Ansan Hospital, College of Medicine, South Korea
    Prog Neuropsychopharmacol Biol Psychiatry 31:1044-53. 2007
    A substantial body of evidence indicates that dysregulation of the immune system is associated with Major Depressive Disorder (MDD)...
  98. pmc Gene expression profiling in postmortem prefrontal cortex of major depressive disorder
    Hyo Jung Kang
    Department Psychiatry, Yale University, New Haven, Connecticut 06508, USA
    J Neurosci 27:13329-40. 2007
    Investigations of the molecular mechanisms underlying major depressive disorder (MDD) have been hampered by the complexity of brain tissue and sensitivity of gene expression profiling approaches...
  99. pmc Imaging the serotonin transporter during major depressive disorder and antidepressant treatment
    Jeffrey H Meyer
    Neurochemical Imaging Program in Mood Disorders, PET Centre, Centre for Addiction and Mental Health, Toronto, Ont
    J Psychiatry Neurosci 32:86-102. 2007
    This paper focuses on serotonin transporter 5-HTT imaging to investigate major depressive disorder (MDD) and antidepressant occupancy...
  100. ncbi Association between major depressive disorder and heart rate variability in the Netherlands Study of Depression and Anxiety (NESDA)
    Carmilla M M Licht
    Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    Arch Gen Psychiatry 65:1358-67. 2008
    ..It has been hypothesized that depression is associated with lower heart rate variability and decreased cardiac vagal control. This may play an important role in the risk of cardiovascular disease among depressed individuals...
  101. pmc A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder
    Rushaniya A Khairova
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Neuropsychopharmacol 12:561-78. 2009
    ..of data suggests that hyperactivation of the immune system has been implicated in the pathophysiology of major depressive disorder (MDD)...

Research Grants82

  1. Neuroimaging abnormalities in major depressive disorder: effect of inflammation
    Jonathan Savitz; Fiscal Year: 2013
    ..LIBR) focusing on bridging the gap between immune dysfunction and neuroimaging abnormalities in major depressive disorder (MDD)...
  2. 5-HT transporter function: Interaction of hormones and antidepressants
    Alan Frazer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The vulnerability of some women to develop major depressive disorder (MDD) is associated with hormonal fluctuations...
  3. Functional Neuroimaging of Individual Differences in Affect and Motivation
    BRIAN JAMES MICKEY; Fiscal Year: 2013
    ..Research. The K23 project focuses on neurobiological vulnerability to major depressive disorder (MDD), a common, debilitating, recurrent brain illness, and a significant public health problem ..
  4. Dietary Supplement Creatine for Adolescent Females with SSRI-Resistant Depression
    PERRY FRANKLIN RENSHAW; Fiscal Year: 2013
    ..Piloting a novel intervention for female adolescents with treatment-resistant major depressive disorder (MDD), while quantifying its engagement of a mechanistic target, supports specific strategies outlined ..
  5. Reversing Corticosteroid-Induced Memory Impairment
    E Sherwood Brown; Fiscal Year: 2013
    ..These have important implications to patients with mood disorders, as a subset of people with major depressive disorder and bipolar disorder have elevated cortisol levels...
  6. Safety signal learning in Rhesus monkeys following early life stressChallenge Ar
    MICHAEL NMN DAVIS; Fiscal Year: 2010
    ..For example, central to the clinical problem of PTSD, which has a ~90% comorbidity with major depressive disorder in patients who had early life stress, is the inability of these patients to inhibit their fear to ..
  7. Genes and Hormonal Fetal Antecedents to Sex Differencs in the Brain in Depression
    Jill M Goldstein; Fiscal Year: 2011
    b>Major depressive disorder (MOD) is the fourth leading cause of disease burden worldwide, and the incidence of MOD in women is twice that of men...
  8. Postpartum Depression: Role of Sleep &Genetic Risk in Postpartum Mood Disorders
    Katherine M Sharkey; Fiscal Year: 2013
    ..a prospective longitudinal study of mood, sleep, and genetic risk in perinatal women with a history of major depressive disorder or bipolar disorder...
  9. Mechanisms of structural plasticity in stress-related disorders
    Scott J Russo; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Mood and anxiety disorders such as major depressive disorder (MDD) and post traumatic stress disorder (PTSD) cause overlapping behavioral symptoms marked by hyperarousal, social avoidance, anxiety, ..
  10. Depression, Adipocytokines and Metabolic Dysregulation in Black and White Women
    Susan A Everson Rose; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Important links between major depressive disorder/depressive symptoms and risk for cardiovascular disease (CVD) morbidity and mortality have been documented...
  11. Transcranial Magnetic Stimulation in Pregnant Women with Depressive Disorder
    Deborah Kim; Fiscal Year: 2013
    ..It is critical that rTMS, as a non-pharmacologic treatment, be evaluated for the treatment of major depressive disorder (MDD) during pregnancy...
  12. Identifying Biomarkers for Post-Partum Depression in African-American Women
    Patrick F Sullivan; Fiscal Year: 2013
    ..contrast to progress for autism, bipolar disorder, and schizophrenia, discerning the biological basis of major depressive disorder (MDD) has been difficult...
  13. The Neurochemistry of Cognitive Therapy: Predicting Treatment Outcome with PET
    Jeffrey M Miller; Fiscal Year: 2013
    ..by applicant): Psychiatrists lack markers that would allow them to select treatments for patients with major depressive disorder (MDD) based on the likelihood of response in individual patients...
  14. Adult Neurogenesis: Regulation By Sleep
    DENNIS J MCGINTY; Fiscal Year: 2013
    ..Insomnia, particularly sleep fragmentation, predicts subsequent major depressive disorder (MDD) and recurrence of MDD in remitted patients...
  15. Web-Based Program to Improve Antidepressant Medication Adherence
    Rebekah K Hersch; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Mood disorders, including major depressive disorder, dysthymia, and bipolar disorder, affect nearly 21 million Americans or 9.5% of the U.S. population age 18 years of age and older...
  16. Using a Biomarker Panel for Detecting Adolescent Depression
    John A Bilello; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Depression (major depressive disorder, MDD) is the most common mental health disorder in the United States among teens and adults...
  17. Effect of Major Depression and antidepressants on human neurogenesis
    Maura Boldrini; Fiscal Year: 2013
    ..Decreased neurogenesis is an emerging model for the etiology of major depressive disorder (MDD). Antidepressant treatment (ADT) increases neurogenesis in the DG of rodents...
  18. Hostility, PTSD and Physical Health Risk Factors
    Jean C Beckham; Fiscal Year: 2013
    ..effects of PTSD by comparing two groups of patients with PTSD including those with and without co-morbid major depressive disorder. The project goals are to examine: (1) the independent relationship between PTSD and biomarkers of ..
  19. Omega-3 Fatty Acids &Psychoeducational Psychotherapy for Childhood Depression
    Mary A Fristad; Fiscal Year: 2013
    ..Approximately 2 to 4% of children experience either major depressive disorder or dysthymic disorder and 5 to 10% of children and adolescents experience subsyndromal depressive ..
  20. The Role of HIF-1 in Neurogenic and Behavior Responses to Antidepressants.
    W TIMOTHY O'BRIEN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Major Depressive Disorder (MDD) is a debilitating mood disorder associated with significant morbidity and mortality...
  21. POST-EXERCISE ION CHANNEL GENE EXPRESSION BIOMARKERS IN CFS
    Kathleen C Light; Fiscal Year: 2013
    ..using our post-exercise gene expression profiles, 2) CFS patients also differ from patients with major depressive disorder and patients with prostate cancer who have cancer-related fatigue;3) these profiles reliably ..
  22. Small Animal Model of HIV Neuropathogenesis in the HAART Era
    Pietro P Sanna; Fiscal Year: 2012
    ..prevalence of milder and chronic forms of HIV central nervous system (CNS) disease and HIV-associated major depressive disorder remains high...
  23. The role of BNST CGRP in stress-enhanced anxiety behavior and HPA-axis function
    Kelly S Sink; Fiscal Year: 2013
    ..are at increased risk for a number of psychiatric illnesses including post-traumatic stress disorder, major depressive disorder, and generalized anxiety disorder...
  24. Examination of Reward Processing in the Treatment of Adolescent Major Depression
    Randy Patrick Auerbach; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The prevalence of major depressive disorder (MDD) increases 5-fold during adolescence, and by the age of 18, approximately 20% of youth will experience a depressive episode...
  25. 5-HT transporter function: Interaction of antidepressants and hormones
    Alan Frazer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The vulnerability of some women to develop major depressive disorder (MDD), which occurs more frequently in women than in men, is associated with hormonal fluctuations (monthly, pregnancy, postpartum,..
  26. Placebo Effects in the Treatment of Depression: Cognitive and Neural Mechanisms
    Bret R Rutherford; Fiscal Year: 2013
    ..to become an expert in the cognitive and neural mechanisms of placebo effects in the treatment of Major Depressive Disorder (MDD)...
  27. Functional Anatomy of REM Sleep: Brainstem-Control
    Gerald A Marks; Fiscal Year: 2013
    ..mechanisms has been hypothesized to be centrally involved in post traumatic stress disorder as well as major depressive disorder . Selective deprivation of REM sleep results in a significant improvement of symptoms in depression...
  28. Hippocampal plasticity in co-morbid diabetes and depression
    LAWRENCE P contact REAGAN; Fiscal Year: 2010
    ..co-morbid diabetes and depression Epidemiological and clinical studies determined that the incidence of major depressive disorder is greater than two fold higher in diabetic patients when compared with non-diabetic patients...
  29. Somatostain & Stress-Related Genes in HIV & Comorbid Major Depressive Disorder
    Ian Paul Everall; Fiscal Year: 2010
    b>Major depressive disorder (MDD) is an etiologically and phenotypically complex disorder causing significant morbidity and mortality...
  30. GENE EXPRESSION EXON ARRAY BIOMARKERS TO DIAGNOSE SCHIZOPHRENIA
    Terry W Osborn; Fiscal Year: 2010
    ..means of genetically diagnosing and differentiating schizophrenia (SZ), bipolar disorder (BD) and Major Depressive Disorder (MDD) from normal/healthy individuals (NC) with mRNA gene expression signatures from a blood sample...
  31. Neuroimmune Factors and Co-Morbid Fear, Depression and Alcohol Consumption
    Michael S Fanselow; Fiscal Year: 2010
    ..Increases in levels of pro-inflammatory cytokines are observed in PTSD, and major depressive disorder (MDD). Microglia as well as pro-inflammatory cytokines are increased in the brains of alcoholics...
  32. Predictors of Treatment Response Relapse and Recurrence in Major Depression
    W Edward Craighead; Fiscal Year: 2012
    ..b>Major Depressive Disorder has a lifetime occurrence rate of 16% and is among the most frequent and debilitating of all medical ..
  33. Optimizing Treatment of Mental Illness during Pregnancy:Improving Infant Outcomes
    Katherine L Wisner; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The period prevalence of major depressive disorder (MDD) was 12.7% during pregnancy and a striking 14.5% women experience postpartum depression...
  34. Trophic factors and regulation of hippocampal neuroplasticity in the human brain
    Maura Boldrini; Fiscal Year: 2012
    ..Decreased neurogenesis is hypothesized in major depressive disorder (MDD)...
  35. A Comprehensive Intervention for Diabetes and Comorbid Depression in Primary Care
    Madhukar H Trivedi; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The prevalence of major depressive disorder (MDD) among patients with diabetes (DM) is twice that of the general population...
  36. Identification and Validation of Human Hypothalamic Nuclei in-vivo and ex-vivo Us
    Nikolaos Makris; Fiscal Year: 2010
    ..In fact, the paraventricular hypothalamic nucleus (PVN) is enlarged in patients with major depressive disorder (MDD), in PVN neurons that are dense in corticotropin releasing hormone (CRH) and estrogen receptor (ER)..
  37. BDNF-Trk Signaling &Cytokines in Patients with Mood Disorders
    Ghanshyam N Pandey; Fiscal Year: 2013
    ..platelets, lymphocytes, neutrophils, and plasma from 40 well-characterized drug-free patients with major depressive disorder (MDD), 40 bipolar manic or mixed (BPM), 40 normal control subjects and from 19 bipolar depressed (BPD) ..
  38. NORADRENERGIC SYSTEM IN DEPRESSION
    GREGORY ALLEN ORDWAY; Fiscal Year: 2012
    ..implicate brain noradrenergic overactivity and norepinephrine (NE) depletion in the neuropathology of major depressive disorder (MDD)...
  39. Neural mechanisms underlying abnormal food reward processing in depressed women
    LAURA MCGRATH HOLSEN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The comorbidity between major depressive disorder (MDD) and obesity appears especially strong in and perhaps limited to females, even controlling for demographic variables, as evidenced by ..
  40. FETAL AND NEONATAL NEUROBEHAVIOR AND PRENATAL ANTIDEPRESSANT EXPOSURE: THE CHILD
    Amy L Salisbury; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Over 400,000 pregnant women and their fetuses experience Major Depressive Disorder (MDD) every year in the United States...
  41. Specificity and Validity of Oxidative Stress Model of Chronic Fatigue Syndrome
    Dikoma C Shungu; Fiscal Year: 2013
    ..that can differentiate the disorder from phenotypically similar psychiatric conditions, such as major depressive disorder (MDD), could thus have a profound impact, not only for how the disorder is generally perceived and ..
  42. Novel transgenic tools for analysis of 5HT2C receptor expression and function
    Ronald B Emeson; Fiscal Year: 2013
    ..5HT2C) has been implicated in a number of human psychiatric and behavioral disorders, including major depressive disorder, dysthymia, obsessive-compulsive disease, anxiety, and schizophrenia...
  43. Calcium Sensing Proteins in Depression
    Yogesh Dwivedi; Fiscal Year: 2013
    ..by applicant): Altered synaptic and structural plasticity play a crucial role in the pathogenesis of major depressive disorder (MDD);however, the precise molecular and cellular nature of events that lead to such altered plasticity ..
  44. The Antidepressant Action of Ketamine:Brain Chemistry
    MATE ISTVAN MILAK; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Major depressive disorder (MDD) is a highly prevalent illness, affecting over 14 million American adults annually...
  45. Bupropion for Depression in ESRD Patients on Hemodialysis
    Pedro L Delgado; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Depressive symptoms, major depressive disorder (MDD), and cognitive impairment are among the most frequent behavioral problems reported in patients with ESRD receiving maintenance hemodialysis (HD)...
  46. Calcium-Stimulated Adenylyl Cyclase Activity's Role in Stress-Facilitated Memory
    LINDSAY ANN WIECZOREK; Fiscal Year: 2010
    ..Two stress- and memory-associated disorders, posttraumatic stress disorder and major depressive disorder, are prime examples of disorders with abnormal stress-facilitated memory processing, and they both have ..
  47. Novel Mechanisms Underlying Depression: PET Imaging of the Kappa Opioid Receptor
    Jeffrey M Miller; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Our understanding of the pathophysiology underlying major depressive disorder (MDD) is incomplete...
  48. Prevalence and Correlates of Minor Depression in Type 2 Diabetes
    Sherita Hill Golden; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Major depressive disorder (MDD) is cross-sectionally and longitudinally associated with risk of type 2 diabetes (T2DM), as well as with an increased risk of micro- and macrovascular complications, ..
  49. HPA Stress Reactivity &Genetic Influences in Postpartum Depression
    SAMANTHA ERIKA MELTZER-BRODY; Fiscal Year: 2013
    ..PPD may be a more homogeneous subset of major depressive disorder (MDD) suggested by its linkage to a puerperal endocrine trigger that is more amenable to searches for ..
  50. The Role of cAMP/PKA Signaling in Neural Circuits Underlying Memory Formation
    Seth M Tomchik; Fiscal Year: 2013
    ..It also appears to be involved in some mental illnesses, as it has been implicated in bipolar disorder, major depressive disorder, and schizophrenia...
  51. Attenuation of Corticosteroid-Induced Hippocampal Changes
    E Sherwood Brown; Fiscal Year: 2013
    ..These findings have important implications for patients with mood disorders, as a subset of people with major depressive disorder and bipolar disorder show evidence of HPA axis activation and elevated cortisol...
  52. Serotonin 1B Receptor Imaging in Major Depressive Disorder
    Alexander Neumeister; Fiscal Year: 2010
    ..by applicant): The serotonin type 1B (5-HT1B) receptor has been implicated in the pathogenesis of major depressive disorder (MDD). Highest concentrations of 5-HT1B receptors are found in the globus pallidus in humans...
  53. The Role of cAMP/PKA Signaling in Neural Circuits Underlying Memory Formation
    Seth M Tomchik; Fiscal Year: 2012
    ..It also appears to be involved in some mental illnesses, as it has been implicated in bipolar disorder, major depressive disorder, and schizophrenia...
  54. Control of Dendritic and Synaptic Development by Extracellular Cues
    GARY ALLEN WAYMAN; Fiscal Year: 2013
    DESCRIPTION (PROVIDED BY APPLICANT): Major Depressive Disorder (MDD) is a recurrent mental illness that afflicts approximately 1 in 6 Americans at least once during their lifetime...
  55. An Investigation of the Clinical Utility of a Prolonged Grief Disorder Diagnosis
    Holly Gwen Prigerson; Fiscal Year: 2013
    ..bereaved virtual standardized patient (VSP) cases with and without PGD (both with and without co-morbid major depressive disorder [MDD] and posttraumatic stress disorder [PTSD];4 cases of spousal loss and 4 cases of child loss) using ..
  56. 3/3-Incomplete Response in Late-Life Depression: Getting to Remission
    Benoit H Mulsant; Fiscal Year: 2013
    ..We propose to enroll 500 patients aged 60 and older with major depressive disorder at the three sites and treat them openly for 12 weeks with venlafaxine XR (up to 225 mg/d) (phase 1)...
  57. 2/2 - Familial Pathways to Early-Onset Suicide Attempts
    JOSEPH JOHN MANN; Fiscal Year: 2013
    ..The cohort consists of 308 offspring of 135 probands with major depressive disorder (MDD) and a history of suicide attempt and a comparison group of 232 offspring of 120 non-attempters ..
  58. Assessing change in short-term therapy for depression using ESM
    Kari M Eddington; Fiscal Year: 2011
    ..Thirty-four adults with primary major depressive disorder will be randomly assigned to 16 weeks of either self-system therapy (SST), a new short-term, empirically-..
  59. A Cognitive Neuroscience Framework for Understanding and Treating Mood Disorders
    Moshe Bar; Fiscal Year: 2012
    ..Among mood disorders, major depressive disorder is a leading cause of disability, affecting annually more than 15 million people, with an estimated ..
  60. Rhodiola rosea Therapy of Major Depressive Disorder
    Jun J Mao; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): This exploratory grant, entitled Rhodiola rosea Therapy of Major Depressive Disorder (MDD), is submitted to the NCCAM under PAR-08-135 to perform human safety and efficacy trials of complementary and ..
  61. AUTOMATED METHODS TO SUPPORT THE DETECTION OF DEPRESSION IN DEMENTIA
    HOWARD D contact WACTLAR; Fiscal Year: 2010
    ..of depression in dementia patients, the NIMH has proposed modifications to the DSM-IV criteria for major depressive disorder that 1) highlight the transient and fluctuating nature of depressive symptoms, 2) addition of social ..
  62. Cortical GABA in MDD and Primary Insomnia with Magnetic Resonance Spectroscopy
    John W Winkelman; Fiscal Year: 2013
    ..applicant): To investigate GABA levels in anterior cingulate cortex (ACC) and occipital cortex (OC) in major depressive disorder (MDD) and primary insomnia with proton magnetic resonance spectroscopy imaging (1H- MRS)...
  63. Development of a Model to Examine Corticosteroid Effects on the Hippocampus
    E Sherwood Brown; Fiscal Year: 2009
    ..findings may have important implications to patients with mood disorders, as a subset of people with major depressive disorder and bipolar disorder show evidence of HPA axis activation...
  64. Adapting Exercise Treatment for Depression to Adolescents: A Pilot Study
    PHILIPPE WEINTRAUB; Fiscal Year: 2010
    ..b>Major depressive disorder (MDD) in adolescence is common with point prevalence rates of 3% to 9%. In the U.S...
  65. Internet Self-Help Program for Major Depressive Disorder in Spouses of Combatants
    Bentson McFarland; Fiscal Year: 2009
    ..There is evidence to suggest that self-help programs on the Internet may be of value for people with major depressive disorder. However, effect sizes in previous research have usually been modest...
  66. Family-Focused Therapy as Early Treatment for Youth at Risk for Bipolar Disorder
    David Miklowitz; Fiscal Year: 2009
    ..relative with bipolar I or II disorder and meet criteria for BD not otherwise specified, cyclothymia, or major depressive disorder with hypomanic symptoms)...
  67. The effects of SAMe on reward circuitry in depression
    Diego Pizzagalli; Fiscal Year: 2007
    b>Major depressive disorder (MOD) is common, recurrent, and disabling. Despite a wide range of antidepressant treatments available, MOD remains difficult to treat...
  68. Using Information Technology to Provide Measurement Based Care for Chronic Illnes
    Madhukar Trivedi; Fiscal Year: 2009
    ..The proposal focuses on the use of MBC to improve the quality of care for patients with major depressive disorder (MDD)...
  69. COGNITIVE THERAPY FOR HIGH RISK & REFRACTORY DEPRESSION
    Robin Jarrett; Fiscal Year: 2003
    ..relapse during the first eight months following response to acute phase CT in outpatients with recurrent major depressive disorder (MDD)...
  70. Processing of emotional content and brain activation in adolescents treated with
    GIOVANNI TIRADO SANTIAGO; Fiscal Year: 2010
    ..cognitive behavioral therapy (CBT) and fluoxetine treatment in adolescents with a positive diagnosis for major depressive disorder (MDD), and b) brain structure and metabolic activity related to the processing of emotional information...
  71. Information Technology Enabled Treatment of Adolescent Depression
    Steven Locke; Fiscal Year: 2009
    ..need for this system innovation arises from the substantial costs that inadequately treated adolescent Major Depressive Disorder (MDD) has on the course of adolescent development and society as a whole...
  72. Does EPA or DHA prevent depressive symptoms in pregnancy and postpartum?
    Ellen Mozurkewich; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Major depressive disorder (MDD) during pregnancy and postpartum depression are associated with significant maternal and neonatal morbidity...
  73. Biomarkers for Outcomes In Late-life Depression (BOLD)
    Ian A Cook; Fiscal Year: 2010
    ..b>Major depressive disorder (MDD) is a common psychiatric illness with high cost to society and individual patients...
  74. HIV and Perinatal Depression in Brazil
    JUDITH KAREN BASS; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Given the high global co-morbidity of HIV and major depressive disorder (MDD), understanding the negative synergistic effects of these two disabling conditions is increasingly important as ..
  75. CONTINUATION ECT VS PHARMACOTHERAPY--EFFICACY AND SAFETY
    Teresa Rummans; Fiscal Year: 2001
    DESCRIPTION (Applicant's abstract): Electroconvulsive therapy (ECT) is a highly effective treatment for major depressive disorder (MDD), that is helpful for patients with the most severe forms of affective illness...
  76. Improving Hispanic Retention in Antidepressant Therapy
    Roberto Lewis Fernandez; Fiscal Year: 2003
    ..in outpatient pharmacological practice by a psychiatrist that will increase retention of Hispanics with major depressive disorder (MDD) in antidepressant therapy...
  77. Stress regulation of the endocannabinoid system: Effects on synaptic physiology
    Christian Reich; Fiscal Year: 2009
    Stress-related disorders such as major depressive disorder and post-traumatic-stress are serious mental illnesses that affect over 20 million Americans...
  78. COGNITION, STEROIDS AND IMAGING IN CUSHINGS DISEASE
    MONICA STARKMAN; Fiscal Year: 2001
    ..a significant proportion of the aged and in neuropsychiatric conditions such as Alzheimer's Disease and Major Depressive Disorder. However, the relationship of this dysregulation to clinical symptoms is still insufficiently understood...
  79. Outpatient versus residential treatment comparison for pregnant substance abusers
    Bentson H McFarland; Fiscal Year: 2010
    ..Substance use during pregnancy is especially worrisome. Moreover, major depressive disorder often co-occurs with substance abuse among women...