Genomes and Genes
Summary: Those disorders that have a disturbance in mood as their predominant feature.
Publications348 found, 100 shown here
- Mood disorders in the medically ill: scientific review and recommendationsDwight L Evans
School of Medicine, University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA 19104, USA
Biol Psychiatry 58:175-89. 2005The purpose of this review is to assess the relationship between mood disorders and development, course, and associated morbidity and mortality of selected medical illnesses, review evidence for treatment, and determine needs in clinical ..
- Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depressionWayne C Drevets
Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health NIH NIMH DIRP, 15K North Dr, Room 210, Bethesda, MD 20892, USA
Brain Struct Funct 213:93-118. 2008..that putatively modulate aspects of normal emotional behavior have been implicated in the pathophysiology of mood disorders by converging evidence from neuroimaging, neuropathological and lesion analysis studies...
- A neurotrophic model for stress-related mood disordersRonald S Duman
Division of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
Biol Psychiatry 59:1116-27. 2006....
- Neurocircuitry of mood disordersJoseph L Price
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO, USA
Neuropsychopharmacology 35:192-216. 2010..A large body of human data from functional and structural imaging, as well as analysis of lesions and histological material indicates that this system is centrally involved in mood disorders.
- Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United StatesRonald C Kessler
Department of Health Care Policy, Harvard Medical School, Boston, MA, USA
Int J Methods Psychiatr Res 21:169-84. 2012..Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) anxiety and mood disorders are presented based on US epidemiological surveys among people aged 13+...
- Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disordersGerard Sanacora
Department of Psychiatry, Clinical Neuroscience Research Unit, Yale University School of Medicine, New Haven, CT, USA
Neuropharmacology 62:63-77. 2012..This article is part of a Special Issue entitled 'Anxiety and Depression'...
- Targeting the glutamatergic system to develop novel, improved therapeutics for mood disordersGerard Sanacora
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Nat Rev Drug Discov 7:426-37. 2008b>Mood disorders are common, chronic, recurrent mental illnesses that affect the lives of millions of individuals worldwide...
- Circadian genes, rhythms and the biology of mood disordersColleen A McClung
Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
Pharmacol Ther 114:222-32. 2007..many years, researchers have suggested that abnormalities in circadian rhythms may underlie the development of mood disorders such as bipolar disorder (BPD), major depression and seasonal affective disorder (SAD)...
- Effects of suppression and acceptance on emotional responses of individuals with anxiety and mood disordersLaura Campbell-Sills
Department of Psychiatry 0985, University of California, San Diego, 8950 Villa La Jolla Drive, Suite C207, La Jolla, CA 92037, USA
Behav Res Ther 44:1251-63. 2006..and physiological effects of emotional suppression and acceptance in a sample of individuals with anxiety and mood disorders. Sixty participants diagnosed with anxiety and mood disorders were randomly assigned to one of two groups...
- Prevalence and incidence studies of mood disorders: a systematic review of the literaturePaul Waraich
Mental Health Evaluation and Community Consultation Unit, University of British Columbia, Vancouver
Can J Psychiatry 49:124-38. 2004..the results of a systematic review of literature published between January 1, 1980, and December 31, 2000, that reports findings on the prevalence and incidence of mood disorders in both general population and primary care settings.
- The subgenual anterior cingulate cortex in mood disordersWayne C Drevets
Section on Neuroimaging in Mood and Anxiety Disorders, Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA
CNS Spectr 13:663-81. 2008..In a combined positron emission tomography/magnetic resonance imaging study of mood disorders, we demonstrated that the mean gray matter volume of this "subgenual" ACC (sgACC) cortex is abnormally reduced ..
- Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: results from the National Epidemiologic Survey on Alcohol and Related ConditionsBridget F Grant
Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 9304, USA
Arch Gen Psychiatry 61:807-16. 2004..Uncertainties exist about the prevalence and comorbidity of substance use disorders and independent mood and anxiety disorders...
- Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated agingNaomi M Simon
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Biol Psychiatry 60:432-5. 2006..is known about the biological mechanisms underlying the excess medical morbidity and mortality associated with mood disorders. Substantial evidence supports abnormalities in stress-related biological systems in depression...
- Decreased BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disordersMia Thompson Ray
Stanley Laboratory of Brain Research, Rockville, MD 20850, USA
J Psychiatry Neurosci 36:195-203. 2011....
- Increased levels of glutamate in brains from patients with mood disordersKenji Hashimoto
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Inohana, Chiba, Japan
Biol Psychiatry 62:1310-6. 2007....
- Brain-derived neurotrophic factor as a biomarker for mood disorders: an historical overview and future directionsKenji Hashimoto
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
Psychiatry Clin Neurosci 64:341-57. 2010b>Mood disorders, such as major depressive disorder (MDD) and bipolar disorder (BPD), are the most prevalent psychiatric conditions, and are also among the most severe and debilitating...
- The leptin hypothesis of depression: a potential link between mood disorders and obesity?Xin Yun Lu
Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
Curr Opin Pharmacol 7:648-52. 2007....
- Abnormal glutamate receptor expression in the medial temporal lobe in schizophrenia and mood disordersMonica Beneyto
Department of Psychiatry, University of Pittsburgh, 3801 O Hara Street, Pittsburgh, PA 15213, USA
Neuropsychopharmacology 32:1888-902. 2007..that abnormal glutamate neurotransmission may be associated with the pathophysiology of schizophrenia and mood disorders. Medial temporal lobe structural alterations have been implicated in schizophrenia and to a lesser extent in ..
- Interaction between BDNF and serotonin: role in mood disordersKeri Martinowich
Mood and Anxiety Disorders Program MAP, NIMH, National Institutes of Health, Bethesda, MD 20892 3714, USA
Neuropsychopharmacology 33:73-83. 2008..of the two systems is their ability to regulate the development and plasticity of neural circuits involved in mood disorders such as depression and anxiety. BDNF promotes the survival and differentiation of 5-HT neurons...
- The biology of tryptophan depletion and mood disordersLilach Toker
Psychiatry Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, and Mental Health Center, Beersheva, Israel
Isr J Psychiatry Relat Sci 47:46-55. 2010..Acute tryptophan depletion as a predictive test for personalized antidepressant treatment is suggested...
- GABA-related transcripts in the dorsolateral prefrontal cortex in mood disordersEtienne Sibille
Department of Psychiatry, University of Pittsburgh, PA, USA
Int J Neuropsychopharmacol 14:721-34. 2011..also be present in bipolar disorder (BPD), the specificity of particular GABA-related molecular deficits in mood disorders is not known...
- Pattern recognition and functional neuroimaging help to discriminate healthy adolescents at risk for mood disorders from low risk adolescentsJanaina Mourao-Miranda
Department of Computer Science, University College London, United Kingdom
PLoS ONE 7:e29482. 2012..identify those healthy genetically at-risk adolescents who were most likely to develop future Axis I disorders...
- Comorbidity studies of eating disorders and mood disorders. Critical review of the literatureN T Godart
Department of Psychiatry, Institut Mutualiste Montsouris IMM, University, René Descartes Paris V, France
J Affect Disord 97:37-49. 2007We conducted a critical literature review of studies assessing the prevalence of mood disorders (MD) in subjects with eating disorders (ED; anorexia nervosa and bulimia nervosa)...
- Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophreniaBryan L Roth
Department of Biochemistry, School of Medicine, Case Western Reserve University, 2109 Adelbert Road, Cleveland, Ohio 44106, USA
Nat Rev Drug Discov 3:353-9. 2004
- Prevalence and effects of mood disorders on work performance in a nationally representative sample of U.S. workersRonald C Kessler
Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115, USA
Am J Psychiatry 163:1561-8. 2006Research on the workplace costs of mood disorders has focused largely on major depressive episodes...
- Neuroimaging abnormalities in the amygdala in mood disordersWayne C Drevets
Mood and Anxiety Disorders Program, Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2670, USA
Ann N Y Acad Sci 985:420-44. 2003Neuroimaging technology has been applied to investigate the pathophysiology of mood disorders in studies aimed at characterizing the anatomical correlates of depressive symptoms, the neurophysiological effects of antidepressant treatments,..
- Mood disorders and allostatic loadBruce S McEwen
Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
Biol Psychiatry 54:200-7. 2003..Allostatic load is seen in major depressive illness and may also be expressed in other chronic anxiety disorders such as PTSD and should be documented...
- Identifying blood biomarkers for mood disorders using convergent functional genomicsH Le-Niculescu
Laboratory of Neurophenomics, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4887, USA
Mol Psychiatry 14:156-74. 2009There are to date no objective clinical laboratory blood tests for mood disorders. The current reliance on patient self-report of symptom severity and on the clinicians' impression is a rate-limiting step in effective treatment and new ..
- Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuitsRichard Levy
Fédération de Neurologie and INSERM U610, Hopital de la Salpetriere, Paris, France
Cereb Cortex 16:916-28. 2006..In both situations (direct basal ganglia lesions and nigro-striatal dopaminergic loss), the capacity of the frontal cortex to select, initiate, maintain and shift programs of actions is impaired...
- Biological rhythms and melatonin in mood disorders and their treatmentsLaurence Lanfumey
INSERM, UMR 894, 75013 Paris, France
Pharmacol Ther 138:176-84. 2013..on the alterations of melatonin secretion and associated changes in biological rhythms that characterize mood disorders. Causal relationships between alterations in circadian rhythms and mood disorders are strongly supported by ..
- Mortality of patients with mood disorders: follow-up over 34-38 yearsF Angst
Institute of Social and Preventive Medicine, Zurich University, Zurich, Switzerland
J Affect Disord 68:167-81. 2002..The reported rates by gender, disorder type and treatment are more variable...
- Decreased glutamic acid decarboxylase(67) mRNA expression in multiple brain areas of patients with schizophrenia and mood disordersMia Thompson
Stanley Laboratory of Brain Research, Rockville, MD 20850, USA
J Psychiatr Res 43:970-7. 2009..The resulting decrease in inhibitory tone across multiple brain areas may contribute to the psychotic behavior observed in patients with schizophrenia and bipolar disorder...
- Overlapping neurobiology of learned helplessness and conditioned defeat: implications for PTSD and mood disordersSayamwong E Hammack
Department of Psychology, University of Vermont, 2 Colchester Avenue, John Dewey Hall, Burlington, VT 05405, USA
Neuropharmacology 62:565-75. 2012..This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'...
- Reductions in cholesterol and synaptic markers in association cortex in mood disordersClare L Beasley
Center for Complex Disorders, Department of Psychiatry, University of British Columbia, Vancouver, Canada
Bipolar Disord 7:449-55. 2005..While low serum cholesterol has previously been associated with mood disorders, cholesterol levels have yet to be quantified within the brain in these disorders...
- Alcoholism and inflammation: neuroimmunology of behavioral and mood disordersKeith W Kelley
Integrative Immunology and Behavior Program, Department of Animal Sciences, College of ACES, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Brain Behav Immun 25:S13-20. 2011Alcohol abuse changes behavior and can induce major mood disorders such as depression...
- Deficits in GABA(B) receptor system in schizophrenia and mood disorders: a postmortem studyS Hossein Fatemi
Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware St SE, MMC 392, Minneapolis, MN 55455, USA
Schizophr Res 128:37-43. 2011..These results provide further evidence of GABAergic dysfunction in these three disorders as well as identify potential targets for therapeutic intervention...
- Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey ReplicationRonald C Kessler
Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
Arch Gen Psychiatry 62:617-27. 2005..Little is known about the general population prevalence or severity of DSM-IV mental disorders...
- Toxoplasma gondii antibody titers and history of suicide attempts in patients with recurrent mood disordersTimothy A Arling
Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Nerv Ment Dis 197:905-8. 2009..T.gondii seropositivity and antibody titers were compared between (a) patients with recurrent mood disorders with history of suicide attempt (99 individuals) versus (b) patients with recurrent mood disorders without ..
- A review of empirically supported psychological therapies for mood disorders in adultsSteven D Hollon
Department of Psychology, Vanderbilt University, Nashville, Tennessee 37203, USA
Depress Anxiety 27:891-932. 2010The mood disorders are prevalent and problematic...
- GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67 kDa and Reelin proteins in cerebellumS Hossein Fatemi
Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, MMC 392, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Schizophr Res 72:109-22. 2005..We hypothesized that levels of GAD and Reelin would be altered in cerebellum of subjects with schizophrenia and mood disorders differentially vs. controls.
- Measurement of temperament and character in mood disorders: a model of fundamental states as personality typesC R Cloninger
Washington University Department of Psychiatry and the Center for Psychobiology of Personality, St Louis, MO 63110, USA
J Affect Disord 51:21-32. 1998Personality assessment may allow reliable measurement of risk of mood disorders.
- Lithium in the prevention of suicidal behavior and all-cause mortality in patients with mood disorders: a systematic review of randomized trialsAndrea Cipriani
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
Am J Psychiatry 162:1805-19. 2005Observational studies suggest that long-term lithium treatment has a strong antisuicidal effect in mood disorders, but it is uncertain whether this association is a genuine therapeutic effect or is due to confounding factors in ..
- Magnetic resonance spectroscopy studies of glutamate-related abnormalities in mood disordersCagri Yüksel
Istanbul University, Turkey
Biol Psychiatry 68:785-94. 2010In mood disorders, there is growing evidence for glutamatergic abnormalities derived from peripheral measures of glutamatergic metabolites in patients, postmortem studies on glutamate-related markers, and animal studies on the mechanism ..
- The thyroid-brain interaction in thyroid disorders and mood disordersM Bauer
Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
J Neuroendocrinol 20:1101-14. 2008..Here, we review the relationship between thyroid hormone and neuropsychiatric symptoms in patients with primary thyroid disease and primary mood disorders.
- Systematic review of the neural basis of social cognition in patients with mood disordersAndrée M Cusi
Mood Disorders Program, St Joseph s Healthcare Hamilton, McMaster University, Hamilton, ON
J Psychiatry Neurosci 37:154-69. 2012..The influence of key clinical and method variables on patterns of neural activation during social cognitive processing is also examined...
- The relationship between Toxoplasma gondii infection and mood disorders in the third National Health and Nutrition SurveyBrad D Pearce
Department of Epidemiology, Emory University, Rollins School of Public Health, Atlanta, GA 30322, USA
Biol Psychiatry 72:290-5. 2012..A substantial literature suggests that schizophrenia is associated with increased seroprevalence of T. gondii, but a possible link of the parasite with mood disorders has not been as thoroughly investigated.
- Structural brain abnormalities in first-episode psychosis: differences between affective psychoses and schizophrenia and relationship to clinical outcomePilar de Castro-Manglano
Section of Neurobiology of Psychosis, NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust and Instituteof Psychiatry, Kings College London, London, UK
Bipolar Disord 13:545-55. 2011..We then assessed whether baseline MRI abnormalities in the entire sample predicted subsequent clinical outcome...
- Glucocorticoid sensitivity in mood disordersA T Spijker
Department of Mood Disorders, PsyQ The Hague, The Netherlands
Neuroendocrinology 95:179-86. 2012In this review, we provide an overview of recent literature on glucocorticoid (GC) sensitivity in mood disorders. Assessing GC sensitivity is often performed by measuring the cortisol awakening rise (CAR), by challenging the hypothalamic-..
- A web-based approach to managing stress and mood disorders in the workforceDouglas W Billings
ISA Associates, Inc, 201 North Union Street, Suite 330, Alexandria, VA 22314 2650, USA
J Occup Environ Med 50:960-8. 2008..To evaluate the effectiveness of a web-based multimedia health promotion program for the workplace, designed to help reduce stress and to prevent depression, anxiety, and substance abuse...
- The serotonergic system in mood disorders and suicidal behaviourJ John Mann
Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 10471, USA
Philos Trans R Soc Lond B Biol Sci 368:20120537. 2013..aggressive traits that are part of the diathesis for suicidal behaviour and are associated with early onset mood disorders and greater risk for suicidal behaviour...
- Targeting glutamatergic signaling for the development of novel therapeutics for mood disordersRodrigo Machado-Vieira
Experimental Therapeutics, Mood and Anxiety Disorders Research Program, National Institute of Mental Health NIH, 10 Center Drive, Bethesda, MD 20892, USA
Curr Pharm Des 15:1595-611. 2009There have been no recent advances in drug development for mood disorders in terms of identifying drug targets that are mechanistically distinct from existing ones...
- Exposure to chronic pregnancy stress reverses peripartum-associated adaptations: implications for postpartum anxiety and mood disordersKatharina M Hillerer
Dept of Behavioral and Molecular Neurobiology, University of Regensburg, 93053 Regensburg, Germany
Endocrinology 152:3930-40. 2011..Thus, prevention of the peripartum-associated increases in basal corticosterone and oxytocin system activity by pregnancy stress reveal two alterations that may increase the risk of postpartum psychiatric disorders, particularly anxiety...
- Dysfunctional hippocampal activity affects emotion and cognition in mood disordersTeresa Femenía
Dep Neuroscience, Karolinska Institutet, Sweden
Brain Res 1476:58-70. 2012b>Mood disorders, such as major depressive disorder (MDD), bipolar disorder and generalized anxiety disorder usually comprise mood related as well as cognitive symptoms and the interaction between these symptoms is still not clear...
- Chronobiological therapy for mood disordersSara Dallaspezia
Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milano, Italy
Expert Rev Neurother 11:961-70. 2011..about the safety and efficacy of chronobiological treatments in everyday psychiatric settings has supported the inclusion of these techniques among the first-line antidepressant strategies for patients affected by mood disorders.
- Association of the GABRD gene and childhood-onset mood disordersY Feng
Genetics and Development Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
Genes Brain Behav 9:668-72. 2010..acid A (GABA(A)) delta receptor subunit gene, GABRD, as a susceptibility gene to childhood-onset mood disorders (COMD) because of substantial evidence implicating GABAergic dysfunction in mood disorders and the position of ..
- Current visual scanpath research: a review of investigations into the psychotic, anxiety, and mood disordersWei Lin Toh
Department of Behavioural Science and Psychiatry, The University of Melbourne, Melbourne, Vic, Australia
Compr Psychiatry 52:567-79. 2011..and critique of eye movement studies in specific clinical populations involving the psychotic, anxiety, and mood disorders, and concludes with suggested directions for future research...
- Gene expression changes in the prefrontal cortex, anterior cingulate cortex and nucleus accumbens of mood disorders subjects that committed suicideAdolfo Sequeira
Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, California, United States of America
PLoS ONE 7:e35367. 2012Suicidal behaviors are frequent in mood disorders patients but only a subset of them ever complete suicide...
- Chronic physical conditions and use of health services among persons with mental disorders: results from the Israel National Health SurveyDaphna Levinson
Ministry of Health, Jerusalem, Israel
Gen Hosp Psychiatry 30:226-32. 2008..This study aimed to determine the association between common mental disorders and common chronic physical conditions and the contribution of mental disorders to the likelihood of being a higher user of health services...
- Volume deficits of subcortical nuclei in mood disorders A postmortem studyHendrik Bielau
Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, 39120, Magdeburg, Germany
Eur Arch Psychiatry Clin Neurosci 255:401-12. 2005Structural changes in subcortical nuclei may underlie clinical symptoms of mood disorders. The goal was to determine whether macrostructural changes exist in brain areas assumed to be involved in regulation of mood and whether such ..
- Intracellular signalling pathways and mood disordersZ Fisar
Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Department of Psychiatry, Prague, Czech Republic
Folia Biol (Praha) 56:135-48. 2010..Psychotropic drugs used in the therapy of a series of mental disorders, mood disorders especially, show neurotrophic or neuroprotective effects after long-term treatment...
- Glial pathology is modified by age in mood disorders--a systematic meta-analysis of serum S100B in vivo studiesMatthias L Schroeter
Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany
J Affect Disord 134:32-8. 2011b>Mood disorders are characterized by specific glial pathology. Recently, based on histopathological post mortem studies, the glial hypothesis has been discussed as a dynamic process, in particular with regard to glioplasticity...
- Striatal structure and function in mood disorders: a comprehensive reviewWilliam R Marchand
Department of Veterans Affairs, VISN 19 MIRECC, 5500 Foothill, Salt Lake City, UT 84148, USA
Bipolar Disord 12:764-85. 2010..Recent functional imaging studies have greatly expanded this body of research. The aim of this review is to provide a comprehensive and critical appraisal of the relevant literature...
- Kappa-opioid ligands in the study and treatment of mood disordersWilliam A Carlezon
Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
Pharmacol Ther 123:334-43. 2009..The development of KOR-selective agents with improved drug-like characteristics would facilitate preclinical and clinical studies designed to evaluate the possibility that KORs are a feasible target for new medications...
- Effects of perceived discrimination on mental health and mental health services utilization among gay, lesbian, bisexual and transgender personsDiana Burgess
Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA
J LGBT Health Res 3:1-14. 2007..We examined the extent to which a recent experience of a major discriminatory event may contribute to poor mental health among LGBT persons...
- Bright-light therapy in the treatment of mood disordersGerald Pail
Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
Neuropsychobiology 64:152-62. 2011..In this review, the authors present a comprehensive overview of the literature on BLT in mood disorders. The first part elucidates the neurobiology of circadian and seasonal adaptive mechanisms focusing on the ..
- Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication I: associations with first onset of DSM-IV disordersJennifer Greif Green
Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
Arch Gen Psychiatry 67:113-23. 2010..Because CAs are highly clustered, this approach results in overestimating the importance of individual CAs. Multivariate CA studies have been based on insufficiently complex models...
- Imaging genetics of mood disordersChristian Scharinger
Division of Biological Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
Neuroimage 53:810-21. 2010b>Mood disorders are highly heritable and have been linked to brain regions of emotion processing...
- The genetics of mood disordersJennifer Y F Lau
Department of Experimental Psychology, University of Oxford, 0X1 4AU, United Kingdom
Annu Rev Clin Psychol 6:313-37. 2010Studying the genetics of mood disorders has never been more exciting. We have moved rapidly from establishing the genetic basis of depression to asking questions about how genes are expressed...
- A systems approach to the biology of mood disorders through network analysis of candidate genesS D Detera-Wadleigh
Human Genetics Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 3719, USA
Pharmacopsychiatry 44:S35-42. 2011Meta analysis of association data of mood disorders has shown evidence for the role of particular genes in genetic risk...
- Acceptability and suppression of negative emotion in anxiety and mood disordersLaura Campbell-Sills
Department of Psychiatry, University of California San Diego, La Jolla, CA 92037, USA
Emotion 6:587-95. 2006..investigated perceived acceptability and suppression of negative emotion in participants with anxiety and mood disorders. Sixty participants with these disorders and 30 control participants watched an emotion-provoking film and ..
- Acceptability of common screening methods used to detect distress and related mood disorders-preferences of cancer specialists and non-specialistsAlex J Mitchell
Liaison Psychiatry, University of Leicester, Brandon Unit, Leicester, UK
Psychooncology 17:226-36. 2008..We suggest that future field studies of screening tools should also measure the issue of acceptability...
- Mental disorders among persons with diabetes--results from the World Mental Health SurveysElizabeth H B Lin
Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
J Psychosom Res 65:571-80. 2008..We assess whether associations of specific mental disorders with diabetes are consistent across diverse countries after controlling for age and gender...
- SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptakeGraziano Pinna
Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, United States
Curr Opin Pharmacol 9:24-30. 2009..Thus, fluoxetine and related congeners facilitate GABA(A) receptor neurotransmission and effectively ameliorate emotional and anxiety disorders and depression by acting as selective brain steroidogenic stimulants (SBSSs)...
- BDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effectsXueying Jiang
Section on Molecular Genetics, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
Neuropsychopharmacology 30:1353-61. 2005..01). Our results suggest that in this population, the low activity -281 A allele may be protective against anxiety and psychiatric morbidity, whereas Met 66 may be a risk allele...
- Does pretreatment severity moderate the efficacy of psychological treatment of adult outpatient depression? A meta-analysisEllen Driessen
Faculty of Psychology and Education, Department of Clinical Psychology, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands
J Consult Clin Psychol 78:668-80. 2010..This study assessed whether pretreatment severity moderates psychological treatment outcome relative to controls by means of meta-analyses...
- Risk of psychiatric disorders among individuals reporting same-sex sexual partners in the National Comorbidity SurveyS E Gilman
Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115, USA
Am J Public Health 91:933-9. 2001..Further research is needed to replicate and explore the causal mechanisms underlying this association...
- Affective cognition and its disruption in mood disordersRebecca Elliott
Neuroscience and Psychiatry Unit, School of Community Based Medicine, University of Manchester, Manchester, UK
Neuropsychopharmacology 36:153-82. 2011..Disturbances of affective cognition are a core and specific feature of mood disorders, and we discuss the evidence supporting this claim, both from behavioral and neuroimaging perspectives...
- The efficacy of light therapy in the treatment of mood disorders: a review and meta-analysis of the evidenceRobert N Golden
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
Am J Psychiatry 162:656-62. 2005The purpose of this study was to assess the evidence base for the efficacy of light therapy in treating mood disorders.
- Glutamatergic modulators: the future of treating mood disorders?Carlos Zarate
Experimental Therapeutics and Pathophysiology Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Harv Rev Psychiatry 18:293-303. 2010b>Mood disorders such as bipolar disorder and major depressive disorder are common, chronic, and recurrent conditions affecting millions of individuals worldwide...
- Prevalence, clinical correlates, and longitudinal course of severe mood dysregulation in childrenMelissa A Brotman
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Biol Psychiatry 60:991-7. 2006..This syndrome has been called the "broad BD phenotype" or severe mood dysregulation (SMD). This study examines prevalence, concurrent Axis I diagnoses, and longitudinal outcome of SMD in an epidemiologic sample...
- A family-based approach to the prevention of depressive symptoms in children at risk: evidence of parental and child changeWilliam R Beardslee
Judge Baker Children s Center, Boston, Massachusetts 02115, USA
Pediatrics 112:e119-31. 2003..Our prevention approaches were designed to provide information about mood disorders to parents, to equip parents with the skills they need to communicate information to their children, and to ..
- Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the complexinsS L Eastwood
University Department of Psychiatry, Warneford Hospital, Oxford, UK
Brain Res Bull 55:569-78. 2001..Altered cytoarchitecture has also been described in this region in schizophrenia as well as in mood disorders. In this paper we review the literature and present a new study investigating synaptic abnormalities in the ..
- Signaling networks in the pathophysiology and treatment of mood disordersTodd D Gould
Laboratory of Molecular Pathophysiology, NIMH, National Institutes of Health, Building 49, Room B1EE16, Bethesda, MD 20892 4405, USA
J Psychosom Res 53:687-97. 2002Over the past decade, the focus of research into the pathophysiology of mood disorders (bipolar disorder and unipolar depression in particular) has shifted from an interest in the biogenic amines to an emphasis on second messenger systems ..
- Developmental trajectories of depressive symptoms from early childhood to late adolescence: gender differences and adult outcomeMarielle C Dekker
Department of Child and Adolescent Psychiatry, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
J Child Psychol Psychiatry 48:657-66. 2007..Limited information is available on gender differences and young-adult poor outcome in children and adolescents following distinct developmental trajectories of depressive symptoms...
- The circadian basis of mood disorders: recent developments and treatment implicationsPalmiero Monteleone
Department of Psychiatry, University of Naples SUN, Large Madonna delle Grazie, Naples, Italy
Eur Neuropsychopharmacol 18:701-11. 2008..b>Mood disorders, especially unipolar depression and seasonal affective disorder, have been linked to circadian rhythm ..
- Current and lifetime comorbidity of the DSM-IV anxiety and mood disorders in a large clinical sampleT A Brown
Center for Anxiety and Related Disorders, Boston University, Massachusetts 02215 2013, USA
J Abnorm Psychol 110:585-99. 2001The comorbidity of current and lifetime DSM-IV anxiety and mood disorders was examined in 1,127 outpatients who were assessed with the Anxiety Disorders Interview Schedule for DSM-IV: Lifetime version (ADIS-IV-L)...
- Three dimensions of oppositionality in youthArgyris Stringaris
King s College London Institute of Psychiatry, London, UK
J Child Psychol Psychiatry 50:216-23. 2009....
- Novel drugs and therapeutic targets for severe mood disordersSanjay J Mathew
Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
Neuropsychopharmacology 33:2080-92. 2008Monoaminergic-based drugs remain the primary focus of pharmaceutical industry drug discovery efforts for mood disorders, despite serious limitations regarding their ability to achieve remission...
- To what extent do oral contraceptives influence mood and affect?Kirsten A Oinonen
Department of Psychology, Lakehead University, Thunder Bay, Ont, Canada P7B 5E1
J Affect Disord 70:229-40. 2002..Studies examining the effects of oral contraceptives (OCs) on mood, affect, and affect variability are reviewed...
- Familial pathways to early-onset suicide attempt: risk for suicidal behavior in offspring of mood-disordered suicide attemptersDavid A Brent
Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Arch Gen Psychiatry 59:801-7. 2002..Although adoption, twin, and family studies have shown that suicidal behavior is familial, the risk factors for familial transmission from parent to child remain unclear...
- Insolubility of disrupted-in-schizophrenia 1 disrupts oligomer-dependent interactions with nuclear distribution element 1 and is associated with sporadic mental diseaseS Rutger Leliveld
Department of Neuropathology, Heinrich Heine University of Dusseldorf, 40225 Dusseldorf, Germany
J Neurosci 28:3839-45. 2008..We conclude that the absence of oligomer-dependent ligand interactions of DISC1 can be associated with sporadic mental disease of mixed phenotypes...
- Anxiety disorders and risk for suicidal ideation and suicide attempts: a population-based longitudinal study of adultsJitender Sareen
Department of Psychiatry, University of Manitoba, 771 Bannatyne Avenue, Winnipeg, Manitoba R3E 3N4, Canada
Arch Gen Psychiatry 62:1249-57. 2005..Controversy exists whether anxiety disorders are independently associated (ie, after adjusting for comorbid mental disorders) with suicidal ideation and suicide attempts...
- An update on regional brain volume differences associated with mood disordersStephanie Campbell
McMaster University Medical Centre, Hamilton, Ontario, Canada
Curr Opin Psychiatry 19:25-33. 2006Structural brain changes are apparent in some magnetic resonance imaging studies of patients with mood disorders, but results are inconsistent...
- Reduced subgenual cingulate volumes in mood disorders: a meta-analysisTomas Hajek
Department of Psychiatry, Dalhousie University, Halifax, NS
J Psychiatry Neurosci 33:91-9. 2008..evidence suggests that the subgenual cingulate (SGC) is implicated in regulation of mood and in the pathophysiology of mood disorders. Our objective was to carry out the first meta-analysis of SGC volumes in patients with mood disorders.
- TEMPS-A: validation of a short version of a self-rated instrument designed to measure variations in temperamentHagop S Akiskal
Department of Psychiatry, International Mood Center, University of California, San Diego, VA Psychiatry 116A, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
J Affect Disord 85:45-52. 2005..Further item wording and selection were achieved at a later stage through an iterative process that incorporated feedback from clinicians, researchers, and research volunteers...
- Review of pharmacological treatment in mood disorders and future directions for drug developmentXiaohua Li
Department of Psychiatry and Behavioral Neuroscience, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Neuropsychopharmacology 37:77-101. 2012..several decades ago, relatively little progress has been made for novel hypothesis-driven drug development in mood disorders. Multifactorial etiologies of, and lack of a full understanding of, the core neurobiology of these conditions ..
- A role for the PKC signaling system in the pathophysiology and treatment of mood disorders: involvement of a functional imbalance?Erika Abrial
Laboratoire de Neuropsychopharmacologie, Universite Lyon 1, 8 avenue Rockefeller, 69373 Lyon Cedex 08, France
Mol Neurobiol 44:407-19. 2011b>Mood disorders, such as bipolar and major depressive disorders, are frequent, severe, and often disabling neuropsychiatric diseases affecting millions of individuals worldwide...
- Oligodendroglial abnormalities in schizophrenia, mood disorders and substance abuse. Comorbidity, shared traits, or molecular phenocopies?Boris P Sokolov
Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD, USA
Int J Neuropsychopharmacol 10:547-55. 2007..The possible mechanisms of oligodendroglial abnormalities may involve functional variations in oligodendroglia-related genes, epigenetic regulation of chromatin, DA system hyperactivity and other mechanisms...
- Influence of phase-related variability in premenstrual symptomatology, mood, smoking withdrawal, and smoking behavior during ad libitum smoking, on smoking cessation outcomeSharon S Allen
Tobacco Use Research Center, University of Minnesota, Medical School, 2701 University Avenue SE, Suite 201, Minneapolis, MN 55414, United States
Addict Behav 34:107-11. 2009..These data support the inference that sex hormones influence smoking cessation outcome. This knowledge may contribute to the development of more rational and effective smoking cessation interventions for women...
- Identification of sialyltransferase 8B as a generalized susceptibility gene for psychotic and mood disorders on chromosome 15q25-26Erica Z McAuley
Psychiatric Genetics, Neuroscience Research Australia, Sydney, New South Wales, Australia
PLoS ONE 7:e38172. 2012....
- Sleep deprivation in mood disordersFrancesco Benedetti
Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
Neuropsychobiology 64:141-51. 2011..suggest that this technique can now be included among the first-line antidepressant treatment strategies for mood disorders. SD targets the broadly defined depressive syndrome, and can be administered according to several different ..
- Postpartum Depression: Omega-3 FA vs PlaceboMarlene Freeman; Fiscal Year: 2006..psychopharmacologic research, statistics, and ethical issues, and 2) to gain expertise in the research on mood disorders during pregnancy and the postpartum period...
- Autonomic, Endothelial, and Inflammatory Correlates of Sleep DurationMERCEDES RENEE CARNETHON; Fiscal Year: 2012..Metabolic syndrome components (blood pressure, lipids, glucose, anthropometrics), the prevalence of mood disorders, medical history, and health behaviors will be determined using standard clinical procedures and ..
- Gamma-Synuclein-Mediated Regulation of Norepinephrine TransporterAnita Sidhu; Fiscal Year: 2010Aberrant norepinephrine [NE] neurotransmission in the human brain is linked to mood disorders, depression, drug addiction and neurodegenerative diseases...
- Neuroimaging abnormalities in major depressive disorder: effect of inflammationJonathan Savitz; Fiscal Year: 2013..This project may constitute a preliminary step towards elucidating one of the pathophysiological mechanisms of mood disorders, potentially facilitating the development of next-generation antidepressant medications that target this ..
- Functional Neuroimaging of Individual Differences in Affect and MotivationBRIAN JAMES MICKEY; Fiscal Year: 2013..award aims to train a promising candidate to become an independent investigator in neuroimaging, genetics, and mood disorders while characterizing neurobiological mechanisms that underlie genetic risk for depression. Candidate...
- Dietary Supplement Creatine for Adolescent Females with SSRI-Resistant DepressionPERRY FRANKLIN RENSHAW; Fiscal Year: 2013..in the brain with translational neuroimaging measures of brain high-energy metabolites that are deficient in mood disorders. Piloting a novel intervention for female adolescents with treatment-resistant major depressive disorder (MDD),..
- NEURAL AND ENDOCRINE CONSEQUENCES OF PARITYROBERT STAFFORD BRIDGES; Fiscal Year: 2012..Overall, reproductive experience-induced shifts in endocrine activities may affect endocrine-related diseases and behaviors later in adulthood, i.e. breast cancer, autoimmune diseases, and postpartum mood disorders.
- Reversing Corticosteroid-Induced Memory ImpairmentE Sherwood Brown; Fiscal Year: 2013..These have important implications to patients with mood disorders, as a subset of people with major depressive disorder and bipolar disorder have elevated cortisol levels...
- Neuroendocrine Mechanisms and Therapeutics in an Animal Model of PTSDDAVID MARK DIAMOND; Fiscal Year: 2013..and mechanistic features of PTSD and to develop more effective treatments of stress-induced anxiety and mood disorders. CLINICAL RELEVANCE: Veterans exposed to traumatic stress during combat have a high incidence of anxiety ..
- Postpartum Depression: Role of Sleep &Genetic Risk in Postpartum Mood DisordersKatherine M Sharkey; Fiscal Year: 2013..5 years of training and research to equip the candidate to examine neurobehavioral and genetic aspects of mood disorders as an independent investigator. The candidate, Katherine M...
- Interactions Between Depression, Neuroinflammation and Glycogen Synthase Kinase-3Eleonore Beurel; Fiscal Year: 2011..which may be particularly important in controlling chronic inflammation that is likely associated with mood disorders. GSK3 also has profound influences in mood disorders, it is inhibited by mood stabilizers and antidepressants, ..
- Mechanisms of structural plasticity in stress-related disordersScott J Russo; Fiscal Year: 2013..data from these basic neurobiological studies will lay the groundwork for the development of novel and more selective pharmacological agents targeting nuclear factor kappa B in the brain to treat or prevent anxiety and mood disorders.
- A translational model of neuro-immune therapy for PTSD in veterans of the OEF/OIFLeonardo H Tonelli; Fiscal Year: 2013..Iraqi Freedom) have a particularly high incidence of PTSD and other mental disorders such as anxiety and mood disorders. A significant problem for the treatment of PTSD is the lack of an appropriate pharmacological or biological ..
- Human VGF Polymorphisms and DepressionStephen R Salton; Fiscal Year: 2010..both of which are clearly impacted by aging, by degenerative diseases such as Alzheimer's or ALS, and by mood disorders such as depression...
- CIRCUITS MEDIATING BEHAVIORAL CONSEQUENCES OF STEROID SENSATIONTimothy E Holy; Fiscal Year: 2013..understanding of steroid effects in the nervous system offers hope for treatment of stress, anxiety, and mood disorders, as well as to shed light on sex differences in neuronal development...
- How do Amine Neurons Work?Edward A Kravitz; Fiscal Year: 2013..Disease in which subsets of the dopamine neurons selectively die, and psychiatric disorders including mood disorders, schizophrenia, attention-deficit hyperactivity disorder and drug abuse in which the amines dopamine, ..
- Regulation of 22q11 Genes in Embroyonic and Adult ForebrainAnthony S LaMantia; Fiscal Year: 2013..vulnerability for language and social cognition deficits, attention deficit/hyperactivity disorder, autism, mood disorders, and schizophrenia...
- Novel Role for Sirtuin Signaling Mechanisms and Downstream Targets in DepressionDeveroux Ferguson; Fiscal Year: 2013..to study the epigenetic mechanisms underlying the gene-environment interactions observed in the onset of major mood disorders. Under the primary mentorship of Dr...
- Interactions Between Depression, Neuroinflammation and Glycogen Synthase Kinase-3Eleonore Beurel; Fiscal Year: 2013..which may be particularly important in controlling chronic inflammation that is likely associated with mood disorders. GSK3 also has profound influences in mood disorders, it is inhibited by mood stabilizers and antidepressants, ..
- Web-Based Program to Improve Antidepressant Medication AdherenceRebekah K Hersch; Fiscal Year: 2011DESCRIPTION (provided by applicant): Mood disorders, including major depressive disorder, dysthymia, and bipolar disorder, affect nearly 21 million Americans or 9.5% of the U.S. population age 18 years of age and older...
- Using a Biomarker Panel for Detecting Adolescent DepressionJohn A Bilello; Fiscal Year: 2010..better less subjective tools are needed to increase the caregivers'ability to identify MDD and other mood disorders within populations...
- Omega-3 Fatty Acids &Psychoeducational Psychotherapy for Childhood DepressionMary A Fristad; Fiscal Year: 2013..Research on treatment of mood disorders with ?3 is promising (Schacter et al, 2005);however, only one RCT has been conducted in children, which was ..
- Endocannabinoid Intracellular TransportersDale G Deutsch; Fiscal Year: 2010..inactivation and identifying FABPs as a new drug target drug target may lead to treatment for addiction, mood disorders, pain and inflammation, cognition, and appetite regulation...
- Longitudinal Studies of Autism Spectrum Disorders: 2 to 23Catherine Lord; Fiscal Year: 2012..Study 2 will focus more specifically on psychiatric comorbidity and mood disorders in ASD, as well as the relationship between coping resources, comorbidity and quality of life...
- Addiction-like behavior in models of mood disorders: role of CLOCK and NPAS2Colleen A McClung; Fiscal Year: 2013..People who have genetic disruptions in circadian gene function are more prone to developing mood disorders such as bipolar disorder or seasonal affective disorder and these disorders are highly co-morbid with ..
- Small-molecule probes of chromatin-mediated neuroplasticityStephen J Haggarty; Fiscal Year: 2013..neuroplasticity and the relevance of these mechanisms to the development of novel therapeutics for memory and mood disorders. PUBLIC HEALTH RELEVANCE: Advancing our understanding of brain plasticity and the development of novel ..
- Melanocortin Signaling in DepressionMichael Lutter; Fiscal Year: 2013..Disruptions in appetite and body weight regulation are among the most important concerns to patients with mood disorders. Metabolic diseases including obesity, type II diabetes mellitus and heart disease are all much more common in ..
- Vascular and Neural Mechanisms of Serotonin-induced Reduction in Blood PressureStephanie W Watts; Fiscal Year: 2013..the committed substrate for 5-HT synthesis, 5-hydroxytryptophan (5-HTP), is taken as an aide for sleep, mood disorders, menopause and many other conditions and causes a fall in blood pressure...
- Hippocampal plasticity in co-morbid diabetes and depressionLAWRENCE P contact REAGAN; Fiscal Year: 2010..In this regard, diabetic patients have higher risk to develop mood disorders like depressive illness when compared to non-diabetic individuals...
- Cellular Mechanisms for the hormonal Modulation of SleepJessica Mong; Fiscal Year: 2009..of this research will advance our understanding of steroid associated control of sleep and how changes in hormonal function lead to sleep pathologies, which in women have been medically correlated with mood disorders.
- Intervention for Menstrual Mood Disorders &Early Life Abuse: Biopsych MechanismsSusan S Girdler; Fiscal Year: 2013..Menstrually related mood disorders (MRMDs), including premenstrual dysphoric disorder (PMDD), are defined by the cyclic recurrence of affective ..
- Seasonality of Mood: A Genome-Wide Association Study in the Old Order AmishTeodor T Postolache; Fiscal Year: 2010..Some patients with recurrent mood disorders develop full major depression syndromes in the fall or winter, with full remission in spring or summer, a ..
- Coregulatory Processes and Postpartum Depression in Mexican-AmericansLinda J Luecken; Fiscal Year: 2013..g., mother-infant interactions) for future interventions. PUBLIC HEALTH RELEVANCE: Postpartum mood disorders, primarily depression, affect a large number of new mothers...
- Neural Markers of Individual Difference in Emotion Regulation in Depressed AdultsJay C Fournier; Fiscal Year: 2013..Dr. Phillips is an expert in the functional neuroimaging of emotion regulation in the context of mood disorders, and Dr. Frank is expert in the assessment and treatment of depression...
- BDNF-Trk Signaling &Cytokines in Patients with Mood DisordersGhanshyam N Pandey; Fiscal Year: 2013..In our previously funded grant we studied the roles of the PI and the Wnt signaling pathways in patients with mood disorders (MD)...
- Neuroimaging mechanisms of overlap between alcoholism and bipolar disorderJAMES JOSEPH PRISCIANDARO; Fiscal Year: 2013..Candidate: Dr. Prisciandaro is a clinical psychologist with extensive training in substance use and mood disorders research and practice, quantitative methods, and initial training in functional Magnetic Resonance Imaging (..
- Neural mechanisms underlying abnormal food reward processing in depressed womenLAURA MCGRATH HOLSEN; Fiscal Year: 2013..in achieving the following goals: a) gain experience in clinical symptomatology and psychiatric treatment of mood disorders, b) develop a knowledge base in the neuroendocrine system, integral to the study of mood disorders and ..
- Broadly Neuroprotective Drug for TBIFernando Gomez Pinilla; Fiscal Year: 2010..and energy metabolism disrupted after TBI, in conjunction with CNB-001 effects on counteracting cognitive, mood disorders, and motor dysfunction...
- VGF function in depression and antidepressant treatmentStephen R Salton; Fiscal Year: 2013..that control emotional behavior and cognition will lead to increased understanding of brain function, mood disorders such as depression, and memory, all clearly impacted by aging and by degenerative diseases including Alzheimer&..
- Gonadal Hormones and Depression:The Role of Mood Disorder Risk Gene CACNA1CTodd D Gould; Fiscal Year: 2012..It is clear that sex differences are a critical consideration to understanding the pathophysiology of mood disorders. While it is hypothesized as likely that susceptibility genes and hormones interact to modify the development ..
- Mechanisms Underlying Sex-Specific Effects of Creatine Supplementation on DepressPATRICIA JOAN ALLEN; Fiscal Year: 2011..in the brain, it is essential to more fully characterize the role of this agent in the pathophysiology of mood disorders. Moreover, examining mechanisms underlying sex differences in depression-like behavior in rats in response to ..
- Neuroendocrine and Neuroimaging Endophenotypes in Postpartum DepressionKRISTINA MARIE DELIGIANNIDIS; Fiscal Year: 2013..knowledge gap and will advance scientific knowledge of biomarker identification in gonadal steroid-modulated mood disorders. To my knowledge, it is the first combined GABA MRS/resting-state functional connectivity MRI study in PPD and ..
- The Functional Significance of Conformational States in Glutamatergic SignalingCATHERINE LOURDES SALUSSOLIA; Fiscal Year: 2013..g. schizophrenia and mood disorders), chronic neurodegenerative diseases (e.g...
- Serotonergic Contribution to Adolescent Risk TakingANDREW EMMETT ARRANT; Fiscal Year: 2012..1 as developmental changes in the serotonergic system could affect the emergence of mood disorders and modulate the effects of drugs used to treat these disorders in adolescents...
- Vasopressin in the regulation of serotonin and anxietyBENJAMIN DAVID ROOD; Fiscal Year: 2013..In particular, anxiety and mood disorders can have devastating effects on social behavior and conversely can be impacted by our social interactions, and ..
- Epigenetic modulation of antidepressant efficacyClaudia Schmauss; Fiscal Year: 2013DESCRIPTION (provided by applicant): Mood disorders are the second leading cause of disability worldwide...
- Mechanisms &Effects of Prenatal Maternal Affect on Pregnancy &Infant DevelopmentChristine Dunkel Schetter; Fiscal Year: 2013..This project will provide important evidence concerning the relationships between antenatal maternal mood disorders, pregnancy-specific stress, and poor pregnancy outcomes, as well as what these relationships mean for infant ..
- Influence of physical activity and weight loss on brain plasticityKirk I Erickson; Fiscal Year: 2013..Impaired cognitive and brain function - manifested as mood disorders, impulsivity, and an increased risk for neurological pathology - are often unrecognized consequences of ..
- Neuroimaging and Behavioral Biomarkers for ADHD in ChildrenMartin H Teicher; Fiscal Year: 2010..disorder had greater impairments in sleep and circadian rhythmicity than children with ADHD and comorbid mood disorders. The validity of these potential markers will be tested in a mixed gender sample of 160 children (80 ADHD, 40 ..
- Cholinergic Mechanisms in Spatial AttentionAnita A Disney; Fiscal Year: 2012..Cognitive and attentional deficits are seen in a number of mental illnesses including schizophrenia, mood disorders and dementias of varying etiology...
- Functional and Structural Neuroanatomy in Late-Life Generalized Anxiety DisorderCarmen Andreescu; Fiscal Year: 2013..Assistant Professor working in the Advanced Center for Interventions and Services Research for Late-life Mood Disorders (ACISR) at the University of Pittsburgh...
- Circadian Clock Genes in Bipolar DisorderMICHAEL JOSEPH MCCARTHY; Fiscal Year: 2013..these added skills, the applicant's long-term goal is to develop expertise in the molecular genetics of mood disorders and function as a physician-scientist to develop biologically-based approaches to treating the mentally ill;an ..
- p38 MAPK Mechanisms of Kappa Opioid-Induced AversionCharles Chavkin; Fiscal Year: 2013..stress response is generally protective, repeated and uncontrollable stress exposure can increase the risks of mood disorders and drug addiction...
- Cellular Circadian Clocks in Mood DisordersDavid K Welsh; Fiscal Year: 2013DESCRIPTION (provided by applicant): Circadian (ca. 24 hr) rhythms are disrupted in mood disorders, and some treatments for mood disorders have specific effects on circadian clocks, pointing to a fundamental connection between cellular ..
- Health Promotion and Fitness for Younger and Older Adults With SMIStephen J Bartels; Fiscal Year: 2012..include 200 adults with SMI stratified by diagnostic group (n=100 schizophrenia-spectrum disorders and n=100 mood disorders) and randomized to either: a) In SHAPE, consisting of a personal fitness assessment and development of diet ..
- Inflammatory Transcripts, Genes and Positive Valence System Function in AnhedoniaJERZY ALEKSANDER BODURKA; Fiscal Year: 2013..In pilot studies of individuals presenting with various mood disorders we obtained preliminary evidence that gene expression within PBMCs is abnormal within a gene network ..
- Attenuation of Corticosteroid-Induced Hippocampal ChangesE Sherwood Brown; Fiscal Year: 2013..These findings have important implications for patients with mood disorders, as a subset of people with major depressive disorder and bipolar disorder show evidence of HPA axis ..
- HPA Stress Reactivity &Genetic Influences in Postpartum DepressionSAMANTHA ERIKA MELTZER-BRODY; Fiscal Year: 2013..has two main hypotheses: 1) change in levels rather than direction of change of gonadal hormones may trigger mood disorders;2) genetic variants in stress axis reactivity may predispose to depression in times of flux of gonadal ..
- Serotonin 1B Receptor Imaging in Major Depressive DisorderAlexander Neumeister; Fiscal Year: 2010..we plan to use as basis for subsequent studies that aim to determine the abnormal processes which underlie mood disorders, guide initial dosing of new therapeutic agents and that are central to predict symptom onset, monitor disease ..
- Effects of lithium on cellular signalingRichard S Jope; Fiscal Year: 2011The etiology of mood disorders is unknown, a critical problem considering their lifetime prevalence of ~20%...
- Assessing the Influence of Oxytocin on Postpartum Depression Using Brain ImagingJulia R Heiman; Fiscal Year: 2010..The extreme psychosocial and physiological changes inherent to motherhood leave many women vulnerable to mood disorders during the year following the birth of an infant...
- A Cognitive Neuroscience Framework for Understanding and Treating Mood DisordersMoshe Bar; Fiscal Year: 2012..notably for diagnosing and treating emotional disorders such as depression, for better understanding a host of mood disorders such as, attention-deficit, bi-polar and post traumatic stress disorders, for contextualizing adult ..
- NEURAL STEROIDOGENIC ENZYMES AND BRAIN FUNCTIONBARNETT ALAN SCHLINGER; Fiscal Year: 2013..These studies contribute to an understanding of basic brain function with implications for the treatment of human cognitive and mood disorders.
- Use of a mouse model of anxious depression to assess the safety of pediatric antiBernhard Luscher; Fiscal Year: 2010..Evidence that such mechanisms might apply to the neurobiological substrate of anxiety and mood disorders is available from GABA-A receptor gamma2 subunit heterozygous mice (gamma2 mice), which have been established ..
- Stress regulation of the endocannabinoid system: Effects on synaptic physiologyChristian Reich; Fiscal Year: 2009..proposal is to determine the function of the endocannabinoid system in the etiology and pathophysiology of mood disorders. My recent work demonstrated that chronic mild stress, an animal model of depression, differentially regulates ..
- Time Course and Potentiation of Fluoxetin ActionGeorge Battaglia; Fiscal Year: 2004..The long-term goal of the proposed studies is to provide novel therapeutic approaches for the treatment of mood disorders that will work more rapidly and more effectively than the currently available medications...
- MENTAL HEALTH RESEARCH TRAININGStanley Watson; Fiscal Year: 2003..postdoctoral fellows in neurobiology and biological psychiatry with particular emphasis on the biology of mood disorders. This program exists in the context of the Mental Health Research Institute (MHRI) of the University of ..
- An fMRI study of the brain circuitry of sad emotion in bereavementPeter J Freed; Fiscal Year: 2011..specializing in the theory and practice of functional magnetic resonance imaging (fMRI) of mood and mood disorders, with a special focus on the relationship of sad emotion to attentional bias in bereavement...
- Serotonin Reuptake Inhibitors and 5-HT1A ReceptorsGeorge Battaglia; Fiscal Year: 2009..that are involved in various physiological functions and play a role in the etiology and/or treatment of mood disorders. Mood disorders are associated with increased activation of the HPA axis that is normalized by antidepressants...
- 18F-Mefway for Imaging Mood Disorders and Alzheimer's DiseaseJOGESH MUKHERJEE; Fiscal Year: 2009..Our particular interest is to apply 5HT1A receptor imaging for the study of mood disorders and AD...
- INTEGRATED TREATMENT FOR COCAINE AND MOOD DISORDERSJoy Schmitz; Fiscal Year: 2003..and logical extension of our previous research evaluating treatments that focus simultaneously on cocaine and mood disorders using integrated cognitive behavioral therapy (CBT) and antidepressant therapy...
- Web Tool to Disseminate Empirically-based Interventions to SchoolsMELISSA DEROSIER; Fiscal Year: 2009..demonstrated for a wide array of child behavioral and emotional disorders, including ADHD, suicidality, mood disorders, and conduct disorders...
- Neuroimaging Markers of Vulnerability to DepressionRonald Dahl; Fiscal Year: 2004..against healthy, low-risk' (LR) controls (who have no evidence of having first or second degree relatives with mood disorders) with respect to PET and MRI imaging measures of neurophysiology, serotoninlA receptor binding potential (BP), ..
- Role of Allopregnanolone in Mediating the Adverse Effects of Psychosocial StressVasiliki Michopoulos; Fiscal Year: 2010The incidence of mood disorders, such as anxiety and depression, in women is twice that in men...
- IRC FOR THE STUDY OF LATE-LIFE MOOD DISORDERSCharles Reynolds; Fiscal Year: 2004This application requests support for an Intervention Research Center in Late-Life Mood Disorders (IRC/LLMD) (PAR-98-020) and is the competing continuation of P30 MH52247 (MHCRC for Late-Life Mood Disorders), funded since March 1, 1995...