tic disorders

Summary

Summary: Disorders characterized by recurrent TICS that may interfere with speech and other activities. Tics are sudden, rapid, nonrhythmic, stereotyped motor movements or vocalizations which may be exacerbated by stress and are generally attenuated during absorbing activities. Tic disorders are distinguished from conditions which feature other types of abnormal movements that may accompany general medical conditions. (From DSM-IV, 1994)

Top Publications

  1. pmc Pediatric autoimmune neuropsychiatric disorders associated with streptococcus: comparison of diagnosis and treatment in the community and at a specialty clinic
    Vilma Gabbay
    Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
    Pediatrics 122:273-8. 2008
  2. ncbi Prevalence of tic disorders: a systematic review and meta-analysis
    Tristan Knight
    Royal College of Surgeons, Dublin, Ireland
    Pediatr Neurol 47:77-90. 2012
  3. pmc Recent advances in Tourette syndrome
    Michael Bloch
    Department of Psychiatry and the Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Curr Opin Neurol 24:119-25. 2011
  4. ncbi Comorbidity of tic disorders & ADHD: conceptual and methodological considerations
    Tobias Banaschewski
    Child and Adolescent Psychiatry, University of Goettingen, Goettingen, Germany
    Eur Child Adolesc Psychiatry 16:5-14. 2007
  5. ncbi Children with comorbid attention-deficit-hyperactivity disorder and tic disorder: evidence for additive inhibitory deficits within the motor system
    G H Moll
    Child and Adolescent Psychiatry Department, , Germany
    Ann Neurol 49:393-6. 2001
  6. ncbi The prevalence and epidemiology of Gilles de la Tourette syndrome. Part 1: the epidemiological and prevalence studies
    Mary M Robertson
    University College, London, United Kingdom
    J Psychosom Res 65:461-72. 2008
  7. ncbi The Autism--Tics, AD/HD and other Comorbidities (A-TAC) telephone interview: convergence with the Child Behavior Checklist (CBCL)
    Sara Lina Hansson Halleröd
    Department of Clinical Sciences, Malmo, Lund University, Sege Park 8A, SE 205 02 Malmo, Sweden
    Nord J Psychiatry 64:218-24. 2010
  8. ncbi Functional brain imaging in Sydenham's chorea and streptococcal tic disorders
    Elvan Caglar Citak
    Department of Pediatric Neurology, Gazi University Medical Faculty, Ankara, Turkey
    J Child Neurol 19:387-90. 2004
  9. pmc European clinical guidelines for Tourette syndrome and other tic disorders. Part I: assessment
    Danielle C Cath
    Department of Clinical and Health Psychology, Utrecht University Altrecht Academic Anxiety Outpatient Services, PO Box 80 140, 3508 TC Utrecht, The Netherlands
    Eur Child Adolesc Psychiatry 20:155-71. 2011
  10. ncbi Psychiatric telephone interview with parents for screening of childhood autism - tics, attention-deficit hyperactivity disorder and other comorbidities (A-TAC): preliminary reliability and validity
    Sara Lina Hansson
    Department of Child and Adolescent Psychiatry, Goteborg University, Sweden
    Br J Psychiatry 187:262-7. 2005

Detail Information

Publications193 found, 100 shown here

  1. pmc Pediatric autoimmune neuropsychiatric disorders associated with streptococcus: comparison of diagnosis and treatment in the community and at a specialty clinic
    Vilma Gabbay
    Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
    Pediatrics 122:273-8. 2008
    ....
  2. ncbi Prevalence of tic disorders: a systematic review and meta-analysis
    Tristan Knight
    Royal College of Surgeons, Dublin, Ireland
    Pediatr Neurol 47:77-90. 2012
    This study evaluated the prevalence of tic disorders. MEDLINE and EMBASE databases were searched, using terms specific to Tourette syndrome and tic disorders, for studies of incidence, prevalence, and epidemiology...
  3. pmc Recent advances in Tourette syndrome
    Michael Bloch
    Department of Psychiatry and the Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Curr Opin Neurol 24:119-25. 2011
    ..This review considers the recent literature pertaining to the neurobiology, genetics and treatment of Tourette syndrome...
  4. ncbi Comorbidity of tic disorders & ADHD: conceptual and methodological considerations
    Tobias Banaschewski
    Child and Adolescent Psychiatry, University of Goettingen, Goettingen, Germany
    Eur Child Adolesc Psychiatry 16:5-14. 2007
    The causes and pathophysiological mechanisms of the common comorbidity of tic disorders and Attention-deficit/Hyperactivity disorder (TD + ADHD; about 50% of TD, about 20% of ADHD) still remain unclear...
  5. ncbi Children with comorbid attention-deficit-hyperactivity disorder and tic disorder: evidence for additive inhibitory deficits within the motor system
    G H Moll
    Child and Adolescent Psychiatry Department, , Germany
    Ann Neurol 49:393-6. 2001
    ..The findings of a reduced intracortical inhibition as well as a shortened cortical silent period in these comorbid children provide evidence for additive effects at the level of motor system excitability...
  6. ncbi The prevalence and epidemiology of Gilles de la Tourette syndrome. Part 1: the epidemiological and prevalence studies
    Mary M Robertson
    University College, London, United Kingdom
    J Psychosom Res 65:461-72. 2008
    ..GTS is found in all other cultures, although to possibly differing degrees. In all cultures where GTS has been reported, the phenomenology is similar, highlighting the biological underpinnings of the disorder...
  7. ncbi The Autism--Tics, AD/HD and other Comorbidities (A-TAC) telephone interview: convergence with the Child Behavior Checklist (CBCL)
    Sara Lina Hansson Halleröd
    Department of Clinical Sciences, Malmo, Lund University, Sege Park 8A, SE 205 02 Malmo, Sweden
    Nord J Psychiatry 64:218-24. 2010
    ....
  8. ncbi Functional brain imaging in Sydenham's chorea and streptococcal tic disorders
    Elvan Caglar Citak
    Department of Pediatric Neurology, Gazi University Medical Faculty, Ankara, Turkey
    J Child Neurol 19:387-90. 2004
    ..However, the number of cases so far investigated by either SPECT or positron emission tomography is still too limited to draw any firm conclusions...
  9. pmc European clinical guidelines for Tourette syndrome and other tic disorders. Part I: assessment
    Danielle C Cath
    Department of Clinical and Health Psychology, Utrecht University Altrecht Academic Anxiety Outpatient Services, PO Box 80 140, 3508 TC Utrecht, The Netherlands
    Eur Child Adolesc Psychiatry 20:155-71. 2011
    ..Detailed clinical assessment guidelines of tic disorders and their comorbidities in both children and adults are presented...
  10. ncbi Psychiatric telephone interview with parents for screening of childhood autism - tics, attention-deficit hyperactivity disorder and other comorbidities (A-TAC): preliminary reliability and validity
    Sara Lina Hansson
    Department of Child and Adolescent Psychiatry, Goteborg University, Sweden
    Br J Psychiatry 187:262-7. 2005
    ..Reliable, valid and easily administered screening instruments would greatly facilitate large-scale neuropsychiatric research...
  11. pmc European clinical guidelines for Tourette syndrome and other tic disorders. Part II: pharmacological treatment
    Veit Roessner
    Department of Child and Adolescent Psychiatry, University of Dresden Medical School, Fetscherstrasse 74, 01307 Dresden, Germany
    Eur Child Adolesc Psychiatry 20:173-96. 2011
    ..and EMBASE search for all studies that document the effect of pharmacological treatment of TS and other tic disorders between 1970 and November 2010...
  12. ncbi Tic disorders: what happens in the basal ganglia?
    Maya Bronfeld
    Bar Ilan University, Ramat Gan, Israel
    Neuroscientist 19:101-8. 2013
    ..This line of research provides a mechanistic description of the underlying neurophysiology of motor tics and may supply the much needed infrastructure for methodical hypothesis-driven studies of novel clinical treatments...
  13. pmc Prevalence of tic disorders among primary school students in the city of Pavia, Italy
    G Lanzi
    Department of Child Neurology and Psychiatry, C Mondino Foundation, University of Pavia, Via Palestro 3, 27100 Pavia, Italy
    Arch Dis Child 89:45-7. 2004
    The prevalence of tic disorders in children varies from 1% to 29% depending on the characteristics of the study population, the diagnostic criteria, and the study design and methods.
  14. ncbi Relative contribution of attention-deficit hyperactivity disorder, obsessive-compulsive disorder, and tic severity to social and behavioral problems in tic disorders
    Pieter J Hoekstra
    Child and Adolescent Psychiatry Center, Groningen, The Netherlands
    J Dev Behav Pediatr 25:272-9. 2004
    ..There was no significant correlation between tic severity and ADHD severity. Thus, in patients with a tic disorder, the presence and severity of ADHD are the main predictors of associated behavioral and social problems...
  15. ncbi Tourette's syndrome in Taiwan: an epidemiological study of tic disorders in an elementary school at Taipei County
    Huei Shyong Wang
    Division of Pediatric Neurology, Chang Gung Children s Hospital, Chang Gung University, Taiwan
    Brain Dev 25:S29-31. 2003
    ..The familial rate of Tourette's syndrome was 27%. We also found that another 98 children had transient tic disorders. For 73% of patients with mild tics, understanding and acceptance from family, teachers, and friends are the ..
  16. ncbi European clinical guidelines for Tourette syndrome and other tic disorders. Part IV: deep brain stimulation
    Kirsten R Müller-Vahl
    Clinic of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Eur Child Adolesc Psychiatry 20:209-17. 2011
    ..It is highly recommended to perform DBS in the context of controlled trials...
  17. ncbi Childhood-onset obsessive-compulsive disorder and tic disorders: case report and literature review
    Lisa A Snider
    Pediatrics and Developmental Neuropsychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Child Adolesc Psychopharmacol 13:S81-8. 2003
    A subgroup of childhood-onset obsessive-compulsive disorder (OCD) and tic disorders has been found to have a postinfectious autoimmune-mediated etiology...
  18. ncbi Tic disorders and obsessive-compulsive disorder: is autoimmunity involved?
    Pieter J Hoekstra
    Child and Adolescent Psychiatry Centre, Groningen, The Netherlands
    Int Rev Psychiatry 17:497-502. 2005
    The precise cause of tic disorders and paediatric obsessive-compulsive disorder (OCD) is unknown...
  19. ncbi Tourette syndrome and other tic disorders in a total population of children: clinical assessment and background
    Najah Khalifa
    Department of Neuroscience, Child and Adolescent Psychiatry, University Hospital, Uppsala, Sweden
    Acta Paediatr 94:1608-14. 2005
    To describe the symptoms, onset, heredity, pre-/perinatal events and socio-economic status in Tourette syndrome (TS) and other tic disorders.
  20. ncbi Prevalence and clinical correlates of tic disorders in a community sample of school-age children
    Janne Tabori Kraft
    Psychiatric Hospital of Children and Adolescents, Aarhus University Hospital, Risskov, Denmark
    Eur Child Adolesc Psychiatry 21:5-13. 2012
    ..13-15 years of age, parents of the children who screened positive for tics were interviewed in detail about tic disorders. The prevalence of Tourette Syndrome (TS) was 0.6 and 0.6% of chronic motor tics (CMT)...
  21. ncbi Tourette syndrome and other tic disorders
    Harvey S Singer
    Departments of Neurology and Pediatrics, Johns Hopkins University School of Medicine, Baltimore 21287, USA
    Handb Clin Neurol 100:641-57. 2011
    b>Tic disorders, including Tourette syndrome, are an intriguing group of paroxysmal movement abnormalities that begin in childhood, have a fluctuating course, are capable of causing psychosocial and physical problems, and often improve by ..
  22. ncbi Tic disorders: administrative prevalence and co-occurrence with attention-deficit/hyperactivity disorder in a German community sample
    M Schlander
    Institute for Innovation and Valuation in Health Care InnoVal HC, An der Ringkirche 4, 65197 Wiesbaden, Germany
    Eur Psychiatry 26:370-4. 2011
    ..Existing data on the co-occurrence of tic disorders, Tourette Syndrome (TS), and ADHD are largely derived from small-scale studies in selected samples and ..
  23. ncbi Tics and problem behaviors in schoolchildren: prevalence, characterization, and associations
    Lisa A Snider
    Pediatrics and Developmental Neuropsychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1255, USA
    Pediatrics 110:331-6. 2002
    b>Tic disorders are the most common movement disorder diagnosed in children and have symptoms that fluctuate in frequency and intensity over time...
  24. ncbi Disruptive behavior problems in a community sample of children with tic disorders
    Lawrence Scahill
    Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Adv Neurol 99:184-90. 2006
  25. ncbi Psychopharmacology of tic disorders in children and adolescents
    Madeline A Chadehumbe
    Division of Pediatric Neurology, Michigan State University, Helen DeVos Children s Hospital, Grand Rapids, MI 49503, USA
    Pediatr Clin North Am 58:259-72, xiii. 2011
    ..This article reviews medications used to treat tic disorders in children and adolescents.
  26. pmc Cognitive-behavioral therapy for childhood repetitive behavior disorders: tic disorders and trichotillomania
    Christopher A Flessner
    Division of Child and Family Psychiatry, Rhode Island Hospital, Warren Alpert School of Medicine at Brown University, Providence, RI 02903, USA
    Child Adolesc Psychiatr Clin N Am 20:319-28. 2011
    ..Because tic disorders and trichotillomania are the most often studied and most debilitating of these conditions, this article ..
  27. ncbi Prevalence of tic disorders among schoolchildren in Warsaw, Poland
    P Stefanoff
    Dept of Epidemiology, National Institute of Hygiene, 24, Chocimska Str, 00 791 Warsaw, Poland
    Eur Child Adolesc Psychiatry 17:171-8. 2008
    To estimate the prevalence and to describe clinical characteristics of tic disorders in 12-15 year old Warsaw schoolchildren.
  28. ncbi Public health significance of tic disorders in children and adolescents
    Lawrence Scahill
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Adv Neurol 96:240-8. 2005
    In conclusion, data from community surveys suggest that tic disorders, including TS, exist on a spectrum from transient to persistent, multiple motor, and vocal tics that interfere with activities of daily living...
  29. ncbi Tics moderate treatment outcome with sertraline but not cognitive-behavior therapy in pediatric obsessive-compulsive disorder
    John S March
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
    Biol Psychiatry 61:344-7. 2007
    ..The presence of a comorbid tic disorder may predict a poorer outcome in the acute treatment of pediatric obsessive-compulsive disorder (OCD)...
  30. ncbi Comparative study of the behavioral and neuropsychologic characteristics of tic disorder with or without attention-deficit hyperactivity disorder (ADHD)
    M S Shin
    Department of Child Psychiatry, Seoul National University College of Medicine, Korea
    J Child Neurol 16:719-26. 2001
    ..The tic disorder with ADHD group might represent a true comorbidity of the two disorders...
  31. ncbi Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases
    S E Swedo
    Section on Behavioral Pediatrics, NIMH, Rockville Pike, Bethesda, MD 20892 1381, USA
    Am J Psychiatry 155:264-71. 1998
    ..the clinical characteristics of a novel group of patients with obsessive-compulsive disorder (OCD) and tic disorders, designated as pediatric autoimmune neuropsychiatric disorders associated with streptococcal (group A beta-..
  32. ncbi An open-label study of the efficacy and tolerability of aripiprazole for children and adolescents with tic disorders
    Hanik K Yoo
    Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    J Clin Psychiatry 68:1088-93. 2007
    ..and tolerability of aripiprazole, an atypical antipsychotic with dual agonist and antagonist actions toward dopaminergic imbalance and partial serotonin-2A receptor antagonism, for treating children and adolescents with tic disorders.
  33. ncbi Treatment of children and adolescents with tics and Tourette syndrome
    Donald Gilbert
    Movement Disorders and Tourette Syndrome Clinics, Cincinnati Children s Hospital Medical Center, OH 45229 3039, USA
    J Child Neurol 21:690-700. 2006
    ..This review focuses primarily on the diagnosis and medical treatment of tics in children and adolescents with Tourette syndrome...
  34. ncbi An open-label, prospective study of guanfacine in children with ADHD and tic disorders
    Vitharon Boon-Yasidhi
    Division of Child Psychiatry, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Bangkok, Thailand
    J Med Assoc Thai 88:S156-62. 2005
    To evaluate the efficacy and safety of guanfacine in children with attention-deficit hyperactivity disorder (ADHD) and tic disorders.
  35. ncbi Atomoxetine treatment in children and adolescents with ADHD and comorbid tic disorders
    A J Allen
    Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Neurology 65:1941-9. 2005
    To test the hypothesis that atomoxetine does not significantly worsen tic severity relative to placebo in children and adolescents with attention deficit/hyperactivity disorder (ADHD) and comorbid tic disorders.
  36. ncbi Atomoxetine use associated with onset of a motor tic
    Marcialee Ledbetter
    Department of Psychiatry and Pediatrics, University of Oklahoma Tulsa, Tulsa, Oklahoma 74135, USA
    J Child Adolesc Psychopharmacol 15:331-3. 2005
    ..with attention-deficit/hyperactivity disorder (ADHD) are at increased risk for Tourette's Disorder and other tic disorders. Stimulant medications and bupropion have been associated with the onset or exacerbation of a tic disorder...
  37. pmc Adulthood outcome of tic and obsessive-compulsive symptom severity in children with Tourette syndrome
    Michael H Bloch
    Yale Child Study Center, and General Clinical Research Center, Yale University School of Medicine, New Haven, CT 06520 7900, USA
    Arch Pediatr Adolesc Med 160:65-9. 2006
    ..One half to two thirds of children with TS experience a reduction or complete resolution of tic symptoms during adolescence. At least one third of adults with TS have comorbid obsessive-compulsive disorder (OCD)...
  38. ncbi Quetiapine for chronic motor tic disorder
    Drew Barzman
    Am J Psychiatry 161:1307. 2004
  39. ncbi Psychopathology in a Swedish population of school children with tic disorders
    Najah Khalifa
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    J Am Acad Child Adolesc Psychiatry 45:1346-53. 2006
    To examine patterns of psychiatric comorbid disorders and associated problems in a school population of children with tic disorders.
  40. ncbi The behavioral spectrum of tic disorders: a community-based study
    R Kurlan
    Department of Neurology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642 8673, USA
    Neurology 59:414-20. 2002
    Tourette syndrome (TS) and related tic disorders are commonly associated with obsessive-compulsive disorder (OCD) and attention deficit hyperactivity disorder (ADHD)...
  41. ncbi [Transcranial magnetic stimulation in child and adolescent psychiatry: excitability of the motor system in tic disorders and/or attention deficit hyperactivity disorders]
    G H Moll
    ,
    Z Kinder Jugendpsychiatr Psychother 29:312-23. 2001
    ....
  42. ncbi Drug and non-drug treatments of children with ADHD and tic disorders
    Yann Poncin
    Child Study Center, Yale University, P O Box 207900, New Haven, CT, 06520, USA
    Eur Child Adolesc Psychiatry 16:78-88. 2007
    To review the treatment of ADHD in children with chronic tic disorders.
  43. ncbi Impact of tic disorders on ADHD outcome across the life cycle: findings from a large group of adults with and without ADHD
    T J Spencer
    Pediatric Psychopharmacology Unit (WACC 725, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114-3117, USA
    Am J Psychiatry 158:611-7. 2001
    OBJECTIVE: The impact of tic disorders on the outcome of attention deficit hyperactivity disorder (ADHD) remains a subject of high scientific and clinical interest...
  44. ncbi A placebo-controlled study of guanfacine in the treatment of children with tic disorders and attention deficit hyperactivity disorder
    L Scahill
    Yale Child Study Center, New Haven, CT 06520, USA
    Am J Psychiatry 158:1067-74. 2001
    This study evaluated the efficacy and safety of guanfacine in treating children with tic disorders and attention deficit hyperactivity disorder (ADHD).
  45. ncbi Color perception deficits in co-existing attention-deficit/hyperactivity disorder and chronic tic disorders
    V Roessner
    Department of Child and Adolescent Psychiatry, University of Goettingen, Goettingen, Germany
    J Neural Transm 115:235-9. 2008
    ..of blue-yellow stimuli, is impaired in attention-deficit/hyperactivity disorder (ADHD) as well as in chronic tic disorders (CTD)...
  46. ncbi Development of tics in a thirteen-year-old male following atomoxetine use
    Jessica Sears
    Pediatric Neurology, Department of Child Health, University of Missouri Columbia, Columbia, MO 65212, USA
    CNS Spectr 13:301-3. 2008
    ..We present a unique case of a patient, without any prior history of a movement disorder, who developed tics following a single dose of atomoxetine that did not improve until interventional therapy was initiated...
  47. ncbi Randomized double-blind multicentre placebo-controlled clinical trial of the clonidine adhesive patch for the treatment of tic disorders
    Ya song Du
    Department of Child and Adolescent Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University, Shanghai, China
    Aust N Z J Psychiatry 42:807-13. 2008
    The aim of the present study was to evaluate the therapeutic effectiveness and safety of the clonidine adhesive patch in treating tic disorders.
  48. pmc Meta-analysis: treatment of attention-deficit/hyperactivity disorder in children with comorbid tic disorders
    Michael H Bloch
    Yale Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    J Am Acad Child Adolesc Psychiatry 48:884-93. 2009
    ..We sought to determine the relative efficacy of different medications in treating ADHD and tic symptoms in children with both Tourette's syndrome and ADHD...
  49. ncbi Sleep patterns in children with attention-deficit/hyperactivity disorder, tic disorder, and comorbidity
    Roumen Kirov
    Institute of Physiology, Bulgarian Academy of Sciences, Sofia, Bulgaria
    J Child Psychol Psychiatry 48:561-70. 2007
    ....
  50. ncbi Tic disorders: from pathophysiology to treatment
    Liborio Rampello
    Department of Neurosciences, University of Catania, Neurology, Azienda Policlinico, Via S Sofia, 78, 95123, Catania, Italy
    J Neurol 253:1-15. 2006
    b>Tic disorders are stereotypic behaviours,more frequent than once believed, and therefore likely to be encountered by primary care physicians...
  51. ncbi Psychopathological profile in children with chronic tic disorder and co-existing ADHD: additive effects
    Veit Roessner
    Department of Child and Adolescent Psychiatry, University of Goettingen, Germany, Von Siebold Strasse 5, 37075 Goettingen, Germany
    J Abnorm Child Psychol 35:79-85. 2007
    The nature of the co-occurrence of chronic tic disorders (CTD) and attention deficit hyperactivity disorder (ADHD) is unclear. Especially in the field of psychopathology, the relationship of CTD and ADHD remains to be clarified...
  52. ncbi Stress fracture of the peroneal bone secondary to a complex tic
    Carlo Fusco
    Child Neurology Unit, Arcispedale Santa Maria Nuova, Viale Risorgimento, 80 42100 Reggio Emilia, Italy
    Brain Dev 28:52-4. 2006
    ..The clinical history was strongly suggestive of obsessive-compulsive disorder and Tourette syndrome with associated simple and complex motor tics. Radiographic follow-up showed spontaneous resolution of the fractures...
  53. ncbi Effectiveness and safety of risperidone for children and adolescents with chronic tic or tourette disorders in Korea
    Boong Nyun Kim
    Division of Child and Adolescent Psychiatry, Department of Psychiatry, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
    J Child Adolesc Psychopharmacol 15:318-24. 2005
    ....
  54. ncbi The symptomatology of tic disorders and concomitant sleep habits in children
    J Młodzikowska-Albrecht
    Chair and Department of Developmental Neurology, Poznan University of Medical Sciences, Poland
    Adv Med Sci 52:212-4. 2007
    The aim of study was to analyze the clinical symptoms of tic disorders (TG) and sleep habits in children. The sleep habits were compared with those of a control group (CG).
  55. ncbi Attentional functions in children and adolescents with attention-deficit/hyperactivity disorder with and without comorbid tic disorder
    E Greimel
    Child Neuropsychology Section, Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of the RWTH Aachen, Aachen, Germany
    J Neural Transm 115:191-200. 2008
    ..Alternatively, compensatory neural mechanisms of TD patients may result in a better neuropsychological performance of comorbid patients relative to patients suffering from pure ADHD...
  56. ncbi Executive functions in children with chronic tic disorders with/without ADHD: new insights
    Veit Roessner
    Dept of Child and Adolescent Psychiatry Psychotherapy, University of Goettingen, Von Siebold Str 5, 37075, Goettingen, Germany
    Eur Child Adolesc Psychiatry 16:36-44. 2007
    In Chronic Tic Disorders (CTD) associated Attention Deficit Hyperactivity Disorder (ADHD) is very common. Hence, it is important to clarify how both conditions are related to cognitive dysfunctions in patients with CTD+ADHD comorbidity...
  57. ncbi Tic disorders: some key issues for DSM-V
    John T Walkup
    Department of Psychiatry, Division of Child and Adolescent Psychiatry, Weill Cornell Medical College, New York, New York 10065, USA
    Depress Anxiety 27:600-10. 2010
    This study provides a focused review of issues that are relevant to the nosology of the tic disorders and presents preliminary recommendations to be considered for DSM-V...
  58. ncbi Quetiapine in the treatment of tic disorder
    Allison E Little
    Ann Pharmacother 40:1472. 2006
  59. ncbi First-onset tics in patients with attention-deficit-hyperactivity disorder: impact of stimulants
    Veit Roessner
    Department of Child and Adolescent Psychiatry, University of Goettingen, Germany
    Dev Med Child Neurol 48:616-21. 2006
    ..The results of high quality studies, in addition to specialized studies with methodological limitations, suggest that stimulants are the criterion standard for the safe and successful treatment of ADHD...
  60. ncbi A systematic review: antipsychotic augmentation with treatment refractory obsessive-compulsive disorder
    M H Bloch
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Psychiatry 11:622-32. 2006
    ..Patients with comorbid tics are likely to have a differential benefit to antipsychotic augmentation...
  61. doi Co-existence of tic disorders and attention-deficit/hyperactivity disorder-recent advances in understanding and treatment
    Aribert Rothenberger
    Eur Child Adolesc Psychiatry 16:1-4. 2007
    In daily clinical practice of child psychiatry tic disorders (TD) and attention-deficit/hyperactivity disorder (ADHD) as well as their co-existence are common and need careful evidence-based approaches in differential diagnostics and ..
  62. ncbi Open label aripiprazole in the treatment of youth with tic disorders
    Tanya K Murphy
    Department of Pediatrics and Psychiatry, University of South Florida, St Petersburg, FL 33701, USA
    J Child Adolesc Psychopharmacol 19:441-7. 2009
    Primarily safe and efficacious treatments for chronic tic disorders are needed. Also needed are such treatments that target co-morbid conditions...
  63. ncbi Efficacy of botulinum toxin in severe Tourette syndrome with dystonic tics involving the neck
    Maria Aguirregomozcorta
    Neurology Department, Hospital Dr Josep Trueta, Girona, Spain
    Parkinsonism Relat Disord 14:443-5. 2008
    ....
  64. ncbi European clinical guidelines for Tourette syndrome and other tic disorders. Part III: behavioural and psychosocial interventions
    Cara Verdellen
    HSK Group Expertise Centre Tics, Hambakenwetering 5B, 5231 DD Den Bosch, The Netherlands
    Eur Child Adolesc Psychiatry 20:197-207. 2011
    ..recommendations for the behavioural and psychosocial interventions (BPI) of children and adolescents with tic disorders prepared by a working group of the European Society for the Study of Tourette Syndrome (ESSTS)...
  65. ncbi Tic reduction with risperidone versus pimozide in a randomized, double-blind, crossover trial
    Donald L Gilbert
    Department of Neurology, Cincinnati Children s Hospital Medical Center, Division of Developmental and Behavioral Sciences Children s Mercy Hospital, Kansas City, KS, USA
    J Am Acad Child Adolesc Psychiatry 43:206-14. 2004
    To compare the tic suppression, electrocardiogram (ECG) changes, weight gain, and side effect profiles of pimozide versus risperidone in children and adolescents with tic disorders.
  66. ncbi Tic reduction with pergolide in a randomized controlled trial in children
    D L Gilbert
    Division of Neurology, Cincinnati Children s Hospital Medical Center, OH 45229 3039, USA
    Neurology 60:606-11. 2003
    To determine whether pergolide, a mixed D1/D2/D3 dopamine agonist, is efficacious and safe in the treatment of children with chronic tic disorders and Tourette syndrome.
  67. ncbi Tics and psychiatric comorbidity in children and adolescents
    Kenneth D Gadow
    Department of Psychiatry and Behavioral Science, State University of New York at Stony Brook, 11794 8790, USA
    Dev Med Child Neurol 44:330-8. 2002
    ..a community-based sample show many similarities with studies of clinically referred samples suggesting that teacher-completed ratings of DSM-IV symptoms may be a useful methodology for investigating the phenomenology of tic disorders.
  68. ncbi A double-blind comparison of desipramine and placebo in children and adolescents with chronic tic disorder and comorbid attention-deficit/hyperactivity disorder
    Thomas Spencer
    Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, MA 02114, USA
    Arch Gen Psychiatry 59:649-56. 2002
    Currently, there is no consensus on the best therapeutic approach to chronic tic disorders and comorbid attention-deficit/hyperactivity disorder (ADHD)...
  69. ncbi Lack of effect of intravenous immunoglobulins on tics: a double-blind placebo-controlled study
    Pieter J Hoekstra
    Child and Adolescent Psychiatry Center, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Clin Psychiatry 65:537-42. 2004
    ..No data are available on the effectiveness of intravenous immunoglobulins (IVIG) on tic severity in unselected tic disorder patients...
  70. ncbi Prospective, longitudinal study of tic, obsessive-compulsive, and attention-deficit/hyperactivity disorders in an epidemiological sample
    B S Peterson
    Yale Child Study Center, Yale University School of Medicine, New Haven CT 06520, USA
    J Am Acad Child Adolesc Psychiatry 40:685-95. 2001
    ..These findings are in general consistent with those from family studies, and they help to define the natural history, comorbid illnesses, and interrelatedness of these conditions...
  71. ncbi Tic disorders: when habit forming neural systems form habits of their own?
    J F Leckman
    Child Study Center, Department of Pediatrics, Yale University, New Haven, CT 06520 7900, USA
    Zhonghua Yi Xue Za Zhi (Taipei) 64:669-92. 2001
    ..It is likely that the research paradigms utilized in these studies and many of the empirical findings resulting from them, will be relevant to other disorders of childhood onset and to our understanding of normal development...
  72. ncbi Comorbidity in ADHD-children: effects of coexisting conduct disorder or tic disorder on event-related brain potentials in an auditory selective-attention task
    A Rothenberger
    Central Institute of Mental Health, Child and Adolescent Psychiatry, Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 250:101-10. 2000
    ..Nd and P300 amplitudes showed no significant group differences. It may be assumed that neurodynamic sufficiency in ADHD-only and ADHD + Tic children seems to be similarly impaired while there might be a greater deficit in ADHD + CD...
  73. ncbi Prevalence of tic disorders and Tourette syndrome in a Swedish school population
    Najah Khalifa
    Department of Women s and Children s Health, University Hospital, Uppsala, Sweden
    Dev Med Child Neurol 45:315-9. 2003
    The aim of the study was to find the epidemiological distribution of tic disorders and Tourette syndrome (TS) in Swedish school children aged 7 to 15 years...
  74. ncbi Association between streptococcal infection and obsessive-compulsive disorder, Tourette's syndrome, and tic disorder
    Loren K Mell
    Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA
    Pediatrics 116:56-60. 2005
    ....
  75. ncbi Obsessive-compulsive disorder in youth with and without a chronic tic disorder
    Eric A Storch
    Department of Psychiatry, University of Florida, Gainesville, Florida 32610, USA
    Depress Anxiety 25:761-7. 2008
    ..Implications of these findings on clinical presentation and treatment efficacy are highlighted...
  76. ncbi Severe obsessive-compulsive disorder with and without comorbid hair pulling: comparisons and clinical implications
    S Evelyn Stewart
    McLean Hospital, Boston, Mass, USA
    J Clin Psychiatry 66:864-9. 2005
    ..This study determined the prevalence of hair pulling in an inpatient obsessive-compulsive disorder (OCD) population and compared clinical characteristics and treatment response between subgroups with and without comorbid hair pulling...
  77. ncbi The familial phenotype of obsessive-compulsive disorder in relation to tic disorders: the Hopkins OCD family study
    M A Grados
    Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, Maryland, USA
    Biol Psychiatry 50:559-65. 2001
    BACKGROUND: Obsessive-compulsive disorder (OCD) and tic disorders have phenomenological and familial-genetic overlaps...
  78. ncbi Tic disorders in the adolescent
    Samuel Kuperman
    Department of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242 1057, USA
    Adolesc Med 13:537-51. 2002
    This chapter addresses the multidimensional nature of tic disorders. The several major dimensions include (1) duration of symptoms (from less than 1 year to lifelong); (2) intensity of symptoms (from mild to severe); (3) frequency of ..
  79. ncbi Adult-onset tic disorders
    Valsamma Eapen
    Department of Psychiatry and Behavioural Sciences, Royal Free and University College, London Medical School, London, United Kingdom
    Mov Disord 17:735-40. 2002
    ..In comparison with DSM-classified, younger-onset Gilles de la Tourette syndrome, adult-onset tic disorders are more often associated with severe symptoms, greater social morbidity, a potential trigger event, increased ..
  80. ncbi Phenomenology of tics and natural history of tic disorders
    James F Leckman
    Child Study Center, Sterling Hall of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Adv Neurol 99:1-16. 2006
  81. ncbi Premonitory Urge for Tics Scale (PUTS): initial psychometric results and examination of the premonitory urge phenomenon in youths with Tic disorders
    Douglas W Woods
    Department of Psychology, University of Wisconsin Milwaukee, 53201, USA
    J Dev Behav Pediatr 26:397-403. 2005
    ..Likewise, significant correlations found between the YGTSS subscales, CBCL subscales, CYBOCS, and the PUTS did not emerge in this younger age group. The clinical and theoretical implications of these findings are discussed...
  82. ncbi Tic disorders: neural circuits, neurochemistry, and neuroimmunology
    Kendra Harris
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Child Neurol 21:678-89. 2006
    The neuroanatomy and neurochemistry underlying tic disorders are thought to involve corticostriatothalamocortical circuits and dysregulation of their component neurotransmitter systems...
  83. ncbi Tourette syndrome and tic disorders: a decade of progress
    James E Swain
    Child Study Center of Yale University, New Haven, CT, USA
    J Am Acad Child Adolesc Psychiatry 46:947-68. 2007
    ..This is a review of progress made in the understanding of Tourette syndrome (TS) during the past decade including models of pathogenesis, state-of-the-art assessment techniques, and treatment...
  84. ncbi The PANDAS subgroup of tic disorders and childhood-onset obsessive-compulsive disorder
    Davide Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, Italy
    J Psychosom Res 67:547-57. 2009
    ..Given the relevance of this topic for general pediatric health, additional research efforts to solve all the pending issues and the hottest points of debate are warranted...
  85. ncbi Sensory phenomena in obsessive-compulsive disorder and tic disorders: a review of the literature
    Helena S Prado
    Department of Psychiatry at the University of São Paulo Medical School, Sao Paulo, Brazil
    CNS Spectr 13:425-32. 2008
    ..This lack of consensus may hinder the understanding of study results and prevents the possibility of including them in the search for etiological factors associated with OCD and TS...
  86. ncbi A family study of early-onset obsessive-compulsive disorder
    Maria Conceição do Rosario-Campos
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 136:92-7. 2005
    ..Childhood onset OCD is a highly familial disorder. Some early-onset cases may represent a valid subgroup, with higher genetic loading and shared vulnerability with chronic tic disorders.
  87. ncbi Combined treatment with haloperidol and trazodone in patients with tic disorders
    L Saccomani
    Child Neuropsychiatry, DSNV, G Gaslini Institute, University of Genova, Italy
    J Child Adolesc Psychopharmacol 10:307-10. 2000
    ..001) between the baseline and endpoint treatment conditions. This approach significantly reduces clinical symptoms, with the advantage of a lower dose of haloperidol than usual, with no side effects reported by the patients...
  88. ncbi Increased prevalence of the seven-repeat variant of the dopamine D4 receptor gene in patients with obsessive-compulsive disorder with tics
    C Cruz
    Departamento de Genética Psiquiátrica, Instituto Mexicano de Psiquiatría Calzada Mexico Xochimilco, San Lorenzo Huipulco, Mexico D F
    Neurosci Lett 231:1-4. 1997
    ..66, P = 0.03). Our study suggests that the seven-repeat allele of the DRD4 gene could be a factor in the phenotypic variance of tics among OCD individuals...
  89. ncbi Group A streptococcal infections and tic disorders in an Italian pediatric population
    F Cardona
    Department of Developmental Neuropsychiatry, University La Sapienza and Istituto Superiore di Sanità, Rome, Italy
    J Pediatr 138:71-5. 2001
    The relationship between childhood tic disorders and group A streptococcal (GAS) infections has been recently investigated by several research groups, but no systematic evaluation of laboratory indicators of GAS infections has been ..
  90. ncbi Use of factor-analyzed symptom dimensions to predict outcome with serotonin reuptake inhibitors and placebo in the treatment of obsessive-compulsive disorder
    D Mataix-Cols
    Department of Psychiatry, Universitat de Barcelona, Spain
    Am J Psychiatry 156:1409-16. 1999
    ..Recent factor analytic studies have identified meaningful symptom dimensions that may be related to response to serotonin reuptake inhibitors and other treatments...
  91. ncbi Prospective longitudinal study of children with tic disorders and/or obsessive-compulsive disorder: relationship of symptom exacerbations to newly acquired streptococcal infections
    Feng Luo
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, USA
    Pediatrics 113:e578-85. 2004
    ..It has been proposed that infection by group A beta-hemolytic streptococci (GABHS) can trigger acute symptom exacerbations among patients with Tourette's syndrome (TS) or obsessive-compulsive disorder (OCD), via autoimmune mechanisms...
  92. ncbi Association studies of serotonin system candidate genes in early-onset obsessive-compulsive disorder
    Diane E Dickel
    Institute of Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA
    Biol Psychiatry 61:322-9. 2007
    ..Early-onset OCD is a more familial form of the disorder...
  93. ncbi Tics and Tourette syndrome in autism spectrum disorders
    Roberto Canitano
    University Hospital of Siena, Italy
    Autism 11:19-28. 2007
    Autism spectrum disorders (ASDs) are more frequently associated with tic disorders than expected by chance. Variable rates of comorbidity have been reported and common genetic and neurobiological factors are probably involved...
  94. ncbi Tics and Tourette's syndrome in childhood
    Samuel Kuperman
    Department of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Semin Pediatr Neurol 10:35-40. 2003
    ..This review describes these dimensions and their relationships to the current diagnostic scheme for tic disorders.
  95. ncbi Decreased numbers of regulatory T cells suggest impaired immune tolerance in children with tourette syndrome: a preliminary study
    Ivana Kawikova
    Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut 06520, USA
    Biol Psychiatry 61:273-8. 2007
    ..We also postulated that group A beta hemolytic streptococcal infections could promote autoimmune responses by releasing exotoxins (streptococcal pyrogenic exotoxins [SPE])...
  96. ncbi [Neuroimaging data of ADHD, tic-disorder and obsessive-compulsive-disorder in children and adolescents]
    Timo D Vloet
    Klinik fur Kinder und Jugendpsychiatrie und psychotherapie, Universitatsklinikum Aachen, Neuenhofer Weg 21, DE 52074 Aachen
    Z Kinder Jugendpsychiatr Psychother 34:343-55. 2006
    ..Since the majority of the studies reviewed are characterised by small and heterogeneous samples, and since the studies differ in their methods, comparability is limited and general conclusions can not be drawn...
  97. ncbi [From tics to obsessive-compulsive disorders in children: a subsequent risk now recognized]
    P Fourneret
    Arch Pediatr 10:464-5. 2003
  98. ncbi Fragile X syndrome associated with tic disorders
    Susanne A Schneider
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 23:1108-12. 2008
    ..We suggest considering fragile X syndrome in GTS complicated by co-morbidity with late onset of atypical tics, in particular when learning disability and dysmorphic features are present...
  99. ncbi Gilles de la Tourette's syndrome
    Kia Faridi
    Department of Psychiatry, McGill University, Montreal, QC, Canada
    Can J Neurol Sci 30:S64-71. 2003
    ..For more severe cases, medications such as tetrabenazine and neuroleptics may be helpful. Treatment of co-morbidities needs to be considered, as these may result in moredisability than the tics themselves...
  100. ncbi Autoimmune neuropsychiatric disorders associated with streptococcal infection: Sydenham chorea, PANDAS, and PANDAS variants
    Piero Pavone
    Department of Pediatrics, Division of Clinical Pediatrics, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy
    J Child Neurol 21:727-36. 2006
    ..In this review, we summarize this complex and rapidly evolving area of clinical research...
  101. ncbi [Gilles de la Tourette syndrome: a clinical study on 58 cases]
    C H Fen
    , , Faculdade de Medicina, , , SP, Brasil
    Arq Neuropsiquiatr 59:729-32. 2001
    ..Associated manifestations, such as attention deficit, hyperactivity disorder and obsessive-compulsive disorder were present in 25.8% and 39.6%, respectively. Sensory phenomena were present in 54.8% of the patients...

Research Grants56

  1. Locus Coeruleus-Norepinephrine System Regulation of Prepulse Inhibition
    Vaishali P Bakshi; Fiscal Year: 2010
    ..filtering systems represents a core endophenotype manifested in schizophrenia, obsessive compulsive disorder, tic disorders, and possibly attention deficit hyperactivity disorder and post traumatic stress disorder...
  2. Quality of life, Comorbidities, and Health Service Utilization in Youth with Tic
    MD MURPHY; Fiscal Year: 2011
    Among neuropsychiatric disorders, tic disorders including Tourette syndrome, affects a large number of children: approximately 1% of those in the general population and up to 20% of students in Exceptional Student Educational classrooms...
  3. Computerized Self Administered Behavioral Intervention for Tics in Children
    Suzanne Mouton-Odum; Fiscal Year: 2012
    ..the feasibility of an innovative computer-based treatment-delivery product for children with Chronic Tic Disorders (CTD;including Tourette's Disorder) and their families...
  4. TESTING THE PHASIC DOPAMINE RELEASE HYPOTHESIS IN TOURETTE SYNDROME: PILOT
    TAMARA G HERSHEY; Fiscal Year: 2013
    ..in their life, and about 3% of all children have a chronic tic disorder such as Tourette syndrome (TS), making tic disorders a subject of substantial public health interest...
  5. Linking Brain and Behavior in Chronic Tic Disorder
    Sandra K Loo; Fiscal Year: 2013
    ..empirically supported behavioral treatments such as Habit Reversal Training (HRT) for individuals with Chronic Tic Disorders (CTDs), including those with Tourette's Syndrome...
  6. Next generation risk variant discovery in a highly penetrant OCD subtype
    Erika L Nurmi; Fiscal Year: 2013
    ..details an approach to mapping risk for a strongly genetic subtype of obsessive compulsive (OCD) and comorbid tic disorders by generating and analyzing whole-exome sequence in select families to identify risk alleles...
  7. Neural Correlates of Tourette Syndrome
    Abhishek Prasad; Fiscal Year: 2011
    ..provided by applicant): Tourette syndrome (TS) is in a class of neuropsychiatric disorders referred to as "tic disorders" which are characterized by involuntary, often repetitive behaviors that can be disruptive, inappropriate, and ..
  8. Clinical and Research Training Curriculum in Behavioral Treatments
    Douglas W Woods; Fiscal Year: 2012
    ..structure as well as existing faculty clinical-research strengths in habit reversal training (HRT) for tic disorders (TD) and trichotillomania (TTM) and behavioral activation (BA) for depression...
  9. Impact of Tics
    Jonathan W Mink; Fiscal Year: 2011
    Project Summary/Abstract Tourette's syndrome (TS) is a childhood-onset tic disorders that is associated with a spectrum of co-occurring neuropsychiatric problems (particularly ADHD and OCD) and that has been found to be much more ..
  10. Identifying de novo mutations causing OCD in trios by whole exome sequencing
    Gerald Nestadt; Fiscal Year: 2013
    ..for characteristics that are shared between unrelated cases with causal variants in the same gene and also by looking for genetic similarities within clearly defined clinical subgroups of patients, such as those with tic disorders.
  11. RTMS for Adults with Severe Tourette Syndrome
    James Leckman; Fiscal Year: 2009
    ..neurocircuitry has been used to guide the design of focal brain stimulation strategies to study and treat tic disorders. Transcranial magnetic stimulation (TMS) has been used to investigate TS for the past decade and repetitive ..
  12. IMPROVING THE OUTCOME OF PATIENTS WITH OCD
    Helen Simpson; Fiscal Year: 2004
    ..and cognitive-behavioral therapy using exposure and ritual prevention (EX/RP), and specialized training in tic disorders); 2) acquire the skills and experiences needed by an independent clinical researcher (by coursework/..
  13. METHYLPHENIDATE TREATMENT OF ADHD IN CHILDREN WITH TS
    Kenneth Gadow; Fiscal Year: 2004
    ..To evaluate the impact of tic severity and comorbid internalizing and externalizing symptoms on clinical outcome, children with ADHD/+tics will be compared with an additional sample of children with ADHD/-tics at ages 11 and 16 years. ..
  14. A Prospective Longitudinal Study of PANDAS
    James Leckman; Fiscal Year: 2005
    b>Tic disorders, obsessive-compulsive disorder (OCD), and related conditions are prevalent disorders affecting as many as 0.3-3 percent of the pediatric population...
  15. PANDAS and Strep Infection: Are they Linked?
    Roger Kurlan; Fiscal Year: 2004
    ..Disproving the PANDAS hypothesis would prevent the use of expensive and potentially dangerous therapies (e.g., plasma exchange, immune globulin, antibiotics) that have been proposed for PANDAS patients. ..
  16. Treating Agitation/Psychosis in Dementia/Parkinsonism
    Roger Kurlan; Fiscal Year: 2004
    ..This study will provide important information regarding the optimal treatment of psychosis and agitation for patients with the commonly encountered combination of primary dementia and parkinsonism. ..
  17. RUPP-PI Program at Yale University
    Lawrence Scahill; Fiscal Year: 2006
    ..Furthermore, this five-site network has established reliability on several measures that are relevant to the conduct of clinical trials in children with PDD. ..
  18. Behavior Therapy for Adults with Tourette Syndrome
    Lawrence Scahill; Fiscal Year: 2009
    ..The Informatics group at Yale University will provide data management services. ..
  19. Pharmacogenetics in Tourette Syndrom
    Harvey Singer; Fiscal Year: 2004
    ..The identification of genetic polymorphisms that are associated with clinical disease or treatment success, has obvious benefits. ..
  20. Anger Control Training for Youth with Tourette Syndrome
    Larry Scahill; Fiscal Year: 2005
    ..This design will permit demonstration of a clinically relevant effect size for anger control training in adolescents with TS. ..
  21. Clinical and Neuropsychological Investigations in Batten Disease
    Jonathan W Mink; Fiscal Year: 2010
    ..Although JNCL is a rare disease, our research has implications that can be generalized to the study of other degenerative neurologic disorders in children and for preparing translational clinical trials in these diseases. ..
  22. Novel Pharmacological Strategies in Autism
    Christopher McDougle; Fiscal Year: 2009
    ..Phase II (following 6 months of aripiprazole monotherapy). ..
  23. Study of risk factors of tick-borne encephalitis in Poland
    Pawel Stefanoff; Fiscal Year: 2009
    ....
  24. MOLECULAR GENETICS OF OBSESSIVE COMPULSIVE DISORDER
    GREGORY HANNA; Fiscal Year: 2001
    ..Parametric and nonparametric linkage analyses will be performed. Once evidence for linkage between early-onset OCD and a genetic marker is found, more precise gene localization will be pursued. ..
  25. RUPP-PI
    Christopher McDougle; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] ..
  26. LINKAGE & ASSOCIATION IN OBSESSIVE-COMPULSIVE DISORDER
    Marco Grados; Fiscal Year: 2006
    ..Based on results from initial analyses and developing collaborations with other research groups future research projects, such as a genome-wide screen of OCD, are considered. ..
  27. PATHOPHYSIOLOGY OF CHOREA
    Jonathan Mink; Fiscal Year: 2002
    ..abstract_text> ..
  28. TREATMENT OF EARLY ONSET SCHIZOPHRENIA SPECTRUM (TEOSS)
    Robert Findling; Fiscal Year: 2005
    ..This study will provide information about the comparative effectiveness of the most commonly used and representative antipsychotic drugs in youth with schizophrenia spectrum disorders. ..
  29. D-Cycloserine Augmentation of Therapy for Pediatric Obsessive-Compulsive Disorder
    Eric Storch; Fiscal Year: 2007
    ..Such agents may have utility in improving outcome, reducing premature therapy termination, and targeting patients who have been treatment refractory. [unreadable] [unreadable] [unreadable]..
  30. BEHAVIOR THERAPY FOR CHILDHOOD OCD
    John Piacentini; Fiscal Year: 2002
    ..The impact of baseline functioning, including family context, and initial change over time on treatment outcome will also be systematically evaluated. ..
  31. Child/Adolescent Anxiety Multimodal Treatment Study
    John Piacentini; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  32. Behavior Therapy for Children with Chronic Tic Disorders
    John Piacentini; Fiscal Year: 2007
    Chronic tic disorders (CTD), including Tourette Syndrome (TS), are neurobehavioral disorders characterized by a persistent pattern of motor and vocal tics...
  33. UTAH AUTISM PROGRAM
    William McMahon; Fiscal Year: 2006
    ..Finally, he proposes to perform microarray analyses on RNA isolated from peripheral blood mononucler cells of autistic children versus control subjects. ..
  34. NEUROIMMUNOLOGY OF CHILDHOOD PSYCHIATRIC DISORDERS
    Tanya Murphy; Fiscal Year: 2005
    ..test the following hypotheses: 1) Is there, evidence of immune dysfunction in children with OCD and/or chronic tic disorders (CTD)?;and 2) Is immune dysfunction more evident during symptom exacerbations? Exploring the role of immune ..
  35. BIOSOCIAL ACTIVATION OF SEX-LINKED COGNITIVE BEHAVIOR
    GERIANNE ALEXANDER; Fiscal Year: 2005
    ..This information will therefore increase understanding of the relations among typical or atypical reproductive events (e.g., puberty, hormone deficiency, pregnancy) and cognition. ..
  36. Dopaminergic Effects on Cortical Function in Tourette's
    Kevin J Black; Fiscal Year: 2010
    Chronic tic disorders including Tourette syndrome (TS) affect at least 2% of all school children and often persist into adulthood...
  37. A Simple Measure for Studying Sensory Gating Deficits
    Neal Swerdlow; Fiscal Year: 2007
    ..abstract_text> ..
  38. NEURAL CIRCUITRY OF SENSORIMOTOR GATING ACROSS SPECIES
    Neal Swerdlow; Fiscal Year: 2006
    ....
  39. NEUROIMAGING OF INHIBITION & STIMULANT RESPONSE IN ADHD
    Steven Pliszka; Fiscal Year: 2004
    ..5) We will control for effects of gender and age, in particular girls with ADHD may not show the same neurobiological mechanisms as boys. ..
  40. Family Based Treatment of Early Childhood OCD
    Henrietta Leonard; Fiscal Year: 2004
    ..At the end of the study, a final revised, comprehensive, manualized treatment protocol would be completed which could be tested in large efficacy and effectiveness studies. ..
  41. Testing Dopaminergic Function Using Pharmacologic FMRI
    Kevin Black; Fiscal Year: 2003
    ..abstract_text> ..
  42. Prospective Study of 'PANDAS'
    Tanya Murphy; Fiscal Year: 2006
    ..The results will help determine if antimicrobial interventions are warranted in certain subtypes of pediatric OCD or TS. ..
  43. Neuroscience at the Boundaries of Neurology and Psychiatry
    Neal Swerdlow; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  44. OCD Collaborative Genetics Association Study
    Gerald Nestadt; Fiscal Year: 2010
    ..The results of these analyses will guide future molecular strategies to identify genes involved in the pathogenesis of OCD. The clinical and genotype data from the sample will be publicly available for OCD genetics research. ..
  45. Depression in Temporal Lobe Epilepsy
    Jana Jones; Fiscal Year: 2005
    ....
  46. Neural basis of heritable DA-mediated gating deficits
    Neal R Swerdlow; Fiscal Year: 2010
    ....
  47. Patterns of Service Use and Costs Associated with Autism
    Douglas Leslie; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  48. Brain Abnormalities in Adolescent Bipolar Disorder
    Melissa Delbello; Fiscal Year: 2006
    ..The research conducted will advance our understanding of the neurophysiology of BPD. ..
  49. IMPACT OF SERVICES ON PROBLEM DRINKING TRAJECTORIES
    Kevin Delucchi; Fiscal Year: 2009
    ....
  50. EPIDEMIOLOGY OF PERSONALITY DISORDERS
    Gerald Nestadt; Fiscal Year: 2008
    ..Building on our previous contributions, this proposal applies innovative constructs of disordered personality and rigorous analytic strategies. ..
  51. CORTICO-STRIATAL SUBSTRATES OF DEFICIENT STARTLE GATING
    Neal R Swerdlow; Fiscal Year: 2010
    ..New information from these studies will be a foundation for innovative models of the pathophysiology of schizophrenia and other inherited neuropsychiatric disorders, and for prospective strategies for novel drug development. ..
  52. Awareness Enhancement and Monitoring Device for Treatment of Trichotillomania
    Joseph Himle; Fiscal Year: 2007
    ..Available psychological treatments are only partially helpful and this device when integrated with current treatments could substantially improve the lives of sufferers and their families. [unreadable] [unreadable] [unreadable]..
  53. Collaborative OCD Genetics Study
    Gerald Nestadt; Fiscal Year: 2005
    ..abstract_text> ..
  54. Dopaminergic Modulation of Working Memory in PD
    Tamara Hershey; Fiscal Year: 2005
    ..Modulation of the lateral prefrontal cortex is predicted during levodopa infusion. The degree of modulation is predicted to depend on baseline dopaminergic status (PD vs control) and the degree of memory load (low vs high). ..
  55. Topiramate for Co-occurring Cannabis Use and Bipolar Disorders in Adolescents
    Melissa Delbello; Fiscal Year: 2008
    ..The preliminary data from this projectwill inform and guide the design of future larger, more definitive, controlled studies of topiramate as a treatment for adolescent substance use disorders. ..