Genomes and Genes
Summary: A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual. (DSM-IV)
Publications369 found, 100 shown here
- The "Reading the Mind in the Eyes" Test revised version: a study with normal adults, and adults with Asperger syndrome or high-functioning autismS Baron-Cohen
Department of Experimental Psychology, University of Cambridge, UK
J Child Psychol Psychiatry 42:241-51. 2001..The Revised Eyes Test has improved power to detect subtle individual differences in social sensitivity...
- The weak coherence account: detail-focused cognitive style in autism spectrum disordersFrancesca Happe
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
J Autism Dev Disord 36:5-25. 2006..Local bias appears not to be a mere side-effect of executive dysfunction, and may be independent of theory of mind deficits. Possible computational and neural models are discussed...
- Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP)Gillian Baird
Newcomen Centre, Guy s and St Thomas NHS Foundation Trust, London, UK
Lancet 368:210-5. 2006..Recent reports have suggested that the prevalence of autism and related spectrum disorders (ASDs) is substantially higher than previously recognised. We sought to quantify prevalence of ASDs in children in South Thames, UK...
- Autism spectrum disorders: developmental disconnection syndromesDaniel H Geschwind
Program in Neurogenetics, Department of Neurology and Semel Institute, David Geffen School of Medicine at University of California Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095, USA
Curr Opin Neurobiol 17:103-11. 2007..This concept of developmental disconnection can accommodate the specific neurobehavioral features that are observed in autism, their emergence during development, and the heterogeneity of autism etiology, behaviors and cognition...
- Strong association of de novo copy number mutations with autismJonathan Sebat
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
Science 316:445-9. 2007..Affected genomic regions were highly heterogeneous and included mutations of single genes. These findings establish de novo germline mutation as a more significant risk factor for ASD than previously recognized...
- The autism-spectrum quotient (AQ): evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematiciansS Baron-Cohen
Departments of Experimental Psychology and Psychiatry, University of Cambridge, Downing Street, Cambridge, CB2 3EB, United Kingdom
J Autism Dev Disord 31:5-17. 2001..Its potential for screening for autism spectrum conditions in adults of normal intelligence remains to be fully explored...
- Transcriptomic analysis of autistic brain reveals convergent molecular pathologyIrina Voineagu
Program in Neurogenetics and Neurobehavioral Genetics, Department of Neurology and Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, California 90095 1769, USA
Nature 474:380-4. 2011..Collectively, our results provide strong evidence for convergent molecular abnormalities in ASD, and implicate transcriptional and splicing dysregulation as underlying mechanisms of neuronal dysfunction in this disorder...
- Autism genome-wide copy number variation reveals ubiquitin and neuronal genesJoseph T Glessner
Center for Applied Genomics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Nature 459:569-73. 2009....
- Neuroligins and neurexins link synaptic function to cognitive diseaseThomas C Sudhof
Neuroscience Institute, Department of Molecular and Cellular Physiology, Stanford University, 1050 Arastradero Road B249, Palo Alto, California 94304, USA
Nature 455:903-11. 2008..In humans, alterations in genes encoding neurexins or neuroligins have recently been implicated in autism and other cognitive diseases, linking synaptic cell adhesion to cognition and its disorders...
- Neocortical excitation/inhibition balance in information processing and social dysfunctionOfer Yizhar
Department of Bioengineering, Stanford University, Stanford, California, USA
Nature 477:171-8. 2011..These results provide support for the elevated cellular E/I balance hypothesis of severe neuropsychiatric disease-related symptoms...
- Neuroglial activation and neuroinflammation in the brain of patients with autismDiana L Vargas
Department of Neurology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
Ann Neurol 57:67-81. 2005..Our findings indicate that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain...
- Mapping autism risk loci using genetic linkage and chromosomal rearrangementsPeter Szatmari
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
Nat Genet 39:319-28. 2007..Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs...
- Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypesHsiao Tuan Chao
Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
Nature 468:263-9. 2010..These data demonstrate that MeCP2 is critical for normal function of GABA-releasing neurons and that subtle dysfunction of GABAergic neurons contributes to numerous neuropsychiatric phenotypes...
- The empathy quotient: an investigation of adults with Asperger syndrome or high functioning autism, and normal sex differencesSimon Baron-Cohen
Autism Research Centre, Department of Experimental Psychology, University of Cambridge, Douglas House, 18b Trumpington Rd, CB2 2AH United Kingdom
J Autism Dev Disord 34:163-75. 2004..This confirmed that women scored significantly higher than men. The EQ reveals both a sex difference in empathy in the general population and an empathy deficit in AS/HFA...
- Rare de novo variants associated with autism implicate a large functional network of genes involved in formation and function of synapsesSarah R Gilman
Center for Computational Biology and Bioinformatics and Department of Biomedical Informatics, Columbia University, 1130 St Nicolas Ave, New York, NY 10032, USA
Neuron 70:898-907. 2011..More generally, our study provides proof of the principle that networks underlying complex human phenotypes can be identified by a network-based functional analysis of rare genetic variants...
- Mutations causing syndromic autism define an axis of synaptic pathophysiologyBenjamin D Auerbach
Howard Hughes Medical Institute, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Nature 480:63-8. 2011..Thus, normal synaptic plasticity and cognition occur within an optimal range of metabotropic glutamate-receptor-mediated protein synthesis, and deviations in either direction can lead to shared behavioural impairments...
- Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disordersMirella Dapretto
Ahmanson Lovelace Brain Mapping Center, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, 90095, USA
Nat Neurosci 9:28-30. 2006..Notably, activity in this area was inversely related to symptom severity in the social domain, suggesting that a dysfunctional 'mirror neuron system' may underlie the social deficits observed in autism...
- Neuroanatomy of autismDavid G Amaral
The M I N D Institute, Department of Psychiatry and Behavioral Sciences, University of California, Davis, 2825 50th Street, Sacramento, CA 95817, USA
Trends Neurosci 31:137-45. 2008..Defined phenotypes in larger samples of children and well-characterized brain tissue will be necessary for clarification of the neuroanatomy of autism...
- Brain region-specific glutathione redox imbalance in autismAbha Chauhan
NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
Neurochem Res 37:1681-9. 2012....
- Why the frontal cortex in autism might be talking only to itself: local over-connectivity but long-distance disconnectionEric Courchesne
Department of Neurosciences, University of California, San Diego, CA, USA
Curr Opin Neurobiol 15:225-30. 2005....
- A genome-wide linkage and association scan reveals novel loci for autismLauren A Weiss
Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Nature 461:802-8. 2009..The linkage regions reported here provide targets for rare variation screening whereas the discovery of a single novel association demonstrates the action of common variants...
- The ESSENCE in child psychiatry: Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical ExaminationsChristopher Gillberg
Institute of Neuroscience and Physiology, Child and Adolescent Psychiatry, University of Goteborg, Sweden
Res Dev Disabil 31:1543-51. 2010..There is no time to wait; something needs to be done, and that something is unlikely to be just in the area of speech and language, just in the area of autism or just in special education...
- Model of autism: increased ratio of excitation/inhibition in key neural systemsJ L R Rubenstein
Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, San Francisco, CA 94143 0984, USA
Genes Brain Behav 2:255-67. 2003..Furthermore, the model suggests potential therapeutic interventions...
- Advances in autism genetics: on the threshold of a new neurobiologyBrett S Abrahams
Neurology Department, and Semel Institute for Neuroscience and Behaviour, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1769 USA
Nat Rev Genet 9:341-55. 2008..Systems biology approaches, including array-based expression profiling, are poised to provide additional insights into this group of disorders, in which heterogeneity, both genetic and phenotypic, is emerging as a dominant theme...
- Shank3 mutant mice display autistic-like behaviours and striatal dysfunctionJoao Peca
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Nature 472:437-42. 2011..Our findings demonstrate a critical role for SHANK3 in the normal development of neuronal connectivity and establish causality between a disruption in the Shank3 gene and the genesis of autistic-like behaviours in mice...
- Neuroanatomic observations of the brain in autism: a review and future directionsMargaret L Bauman
Children s Neurology Service, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA
Int J Dev Neurosci 23:183-7. 2005..These findings combined with reported age-related changes in brain weight and volume, have raised the possibility that the neuropathology of autism may represent an on-going process...
- Understanding the nature of face processing impairment in autism: insights from behavioral and electrophysiological studiesGeraldine Dawson
University of Washington Autism Center, University of Washington, Seattle 98195, USA
Dev Neuropsychol 27:403-24. 2005..This article discusses implications for intervention...
- AutDB: a gene reference resource for autism researchSaumyendra N Basu
MindSpec Inc, 9656 Blake Lane, Fairfax, VA 22031, USA
Nucleic Acids Res 37:D832-6. 2009..Our model for consolidated knowledge representation in genetically complex disorders could be replicated to study other such disorders...
- Disruption of neurexin 1 associated with autism spectrum disorderHyung Goo Kim
Molecular Neurogenetics Unit, Center for Human Genetic Research and Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Am J Hum Genet 82:199-207. 2008....
- Autism and abnormal development of brain connectivityMatthew K Belmonte
Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge CB2 2AH, United Kingdom
J Neurosci 24:9228-31. 2004
- Understanding and sharing intentions: the origins of cultural cognitionMichael Tomasello
Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
Behav Brain Sci 28:675-91; discussion 691-735. 2005..The developmental outcome is children's ability to construct dialogic cognitive representations, which enable them to participate in earnest in the collectivity that is human cognition...
- Differences in white matter fiber tract development present from 6 to 24 months in infants with autismJason J Wolff
Carolina Institute for Developmental Disabilities and the Department of Psychiatry, University of North Carolina, Chapel Hill, USA
Am J Psychiatry 169:589-600. 2012..The authors prospectively examined white matter fiber tract organization from 6 to 24 months in high-risk infants who developed autism spectrum disorders (ASDs) by 24 months...
- Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autismIgor Splawski
Department of Cardiology, Children s Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA
Cell 119:19-31. 2004..These discoveries establish the importance of Ca(V)1.2 in human physiology and development and implicate Ca(2+) signaling in autism...
- Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disordersChristelle M Durand
Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
Nat Genet 39:25-7. 2007..These mutations concern only a small number of individuals, but they shed light on one gene dosage-sensitive synaptic pathway that is involved in autism spectrum disorders...
- Functional and anatomical cortical underconnectivity in autism: evidence from an FMRI study of an executive function task and corpus callosum morphometryMarcel Adam Just
Center for Cognitive Brain Imaging, Carnegie Mellon University, Pittsburgh, PA 15213, USA
Cereb Cortex 17:951-61. 2007..The results add support to a new theory of cortical underconnectivity in autism, which posits a deficit in integration of information at the neural and cognitive levels...
- Developmental deficits in social perception in autism: the role of the amygdala and fusiform face areaRobert T Schultz
Yale Child Study Center, 230 S Frontage Road, PO Box 207900, New Haven, CT 06520 7900, USA
Int J Dev Neurosci 23:125-41. 2005..It is argued that the development of face perception and social cognitive skills are supported by the amygdala-fusiform system, and that deficits in this network are instrumental in causing autism...
- Identifying autism loci and genes by tracing recent shared ancestryEric M Morrow
Division of Genetics, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
Science 321:218-23. 2008....
- Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in miceS S Moy
North Carolina STAART Center for Autism Research, Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Genes Brain Behav 3:287-302. 2004..This new standardized procedure to quantitate sociability and preference for social novelty in mice provides a method to assess tendencies for social avoidance in mouse models of autism...
- Autistic traits in the general population: a twin studyJohn N Constantino
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Arch Gen Psychiatry 60:524-30. 2003....
- A synaptic trek to autismThomas Bourgeron
Human Genetics and Cognitive Functions, Institut Pasteur, 25 rue du Docteur Roux, 75015 Paris, France
Curr Opin Neurobiol 19:231-4. 2009..Taken together, these data strongly suggest that abnormal synaptic homeostasis represent a risk factor to ASD...
- Visual fixation patterns during viewing of naturalistic social situations as predictors of social competence in individuals with autismAmi Klin
Yale Child Study Center, Yale University, 230 S Frontage Rd, New Haven, CT 06520, USA
Arch Gen Psychiatry 59:809-16. 2002..Enhanced ecological validity was intended to maximize between-group effect sizes and assess the predictive utility of experimental variables relative to outcome measures of social competence...
- Infant neural sensitivity to dynamic eye gaze is associated with later emerging autismMayada Elsabbagh
Centre for Brain and Cognitive Development, Birkbeck College, University of London, London WC1E 7HX, UK
Curr Biol 22:338-42. 2012..ERP responses to eye gaze may help characterize developmental processes that lead to later emerging autism. Findings also elucidate the mechanisms driving the development of the social brain in infancy...
- The genetics of autismRebecca Muhle
Class of 2004, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Pediatrics 113:e472-86. 2004..affected individuals to mutations of the methyl-CpG-binding protein 2 (MeCP2) gene--the other PDD subtypes (autistic disorder, Asperger disorder, disintegrative disorder, and PDD Not Otherwise Specified [PDD-NOS]) are not linked to ..
- The mirror neuron system and the consequences of its dysfunctionMarco Iacoboni
Ahmanson Lovelace Brain Mapping Center, Department of Psychiatry and Biobehavioural Sciences, Neuropsychiatric Institute, Brain Research Institute, David Geffen School of Medicine, University of California, Los Angeles 90095, USA
Nat Rev Neurosci 7:942-51. 2006..Here, we review the neurophysiology of the mirror neuron system and its role in social cognition and discuss the clinical implications of mirror neuron dysfunction...
- Cortical activation and synchronization during sentence comprehension in high-functioning autism: evidence of underconnectivityMarcel Adam Just
Carnegie Mellon University, Center for Cognitive Brain Imaging, Department of Psychology, Pittsburgh, PA 15213, USA
Brain 127:1811-21. 2004..The article presents a theoretical account of the findings, related to neurobiological foundations of underconnectivity in autism...
- Enhanced perceptual functioning in autism: an update, and eight principles of autistic perceptionLaurent Mottron
Pervasive Developmental Disorders Specialized Clinic, Riviere des Prairies Hospital, and Fernand Seguin Research Center, University of Montreal, Canada
J Autism Dev Disord 36:27-43. 2006..The overfunctioning of brain regions typically involved in primary perceptual functions may explain the autistic perceptual endophenotype...
- Neuron number and size in prefrontal cortex of children with autismEric Courchesne
Department of Neuroscience, NIH UCSD Autism Center of Excellence, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
JAMA 306:2001-10. 2011..Autism often involves early brain overgrowth, including the prefrontal cortex (PFC). Although prefrontal abnormality has been theorized to underlie some autistic symptoms, the cellular defects that cause abnormal overgrowth remain unknown...
- Consensus paper: pathological role of the cerebellum in autismS Hossein Fatemi
University of Minnesota Medical School, 420 Delaware St SE, Minneapolis, MN 55455, USA
Cerebellum 11:777-807. 2012....
- Brain growth across the life span in autism: age-specific changes in anatomical pathologyEric Courchesne
Department of Neuroscience, Autism Center of Excellence, University of California, San Diego, CA, USA
Brain Res 1380:138-45. 2011....
- The autistic neuron: troubled translation?Raymond J Kelleher
Center for Human Genetic Research, Harvard Partners Center for Genetics and Genomics, Massachusetts General Hospital, Program in Neuroscience and Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
Cell 135:401-6. 2008..We propose that aberrant synaptic protein synthesis may represent one possible pathway leading to autistic phenotypes, including cognitive impairment and savant abilities...
- X-linked mental retardation and autism are associated with a mutation in the NLGN4 gene, a member of the neuroligin familyFrederic Laumonnier
INSERM U619 Génétique de l Autisme et de la Déficience Mentale, CHU Bretonneau, Tours, France
Am J Hum Genet 74:552-7. 2004..retarded males suggests that the NLGN4 gene is not only involved in autism, as previously described, but also in mental retardation, indicating that some types of autistic disorder and mental retardation may have common genetic origins.
- Psychiatric disorders in children with autism spectrum disorders: prevalence, comorbidity, and associated factors in a population-derived sampleEmily Simonoff
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
J Am Acad Child Adolesc Psychiatry 47:921-9. 2008..We identify the rates and type of psychiatric comorbidity associated with ASDs and explore the associations with variables identified as risk factors for child psychiatric disorders...
- Executive dysfunction in autismElisabeth L Hill
Department of Psychology, Goldsmiths College, University of London, Whitehead Building, New Cross, London SE14 6NW, UK
Trends Cogn Sci 8:26-32. 2004..It is concluded that more detailed research is needed to fractionate the executive system in autism by assessing a wide range of executive functions as well as their neuroanatomical correlates in the same individuals across the lifespan...
- Structural variation of chromosomes in autism spectrum disorderChristian R Marshall
The Centre for Applied Genomics, The Hospital for Sick Children, Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5G 1L7, Canada
Am J Hum Genet 82:477-88. 2008..Structural variants were found in sufficiently high frequency influencing ASD to suggest that cytogenetic and microarray analyses be considered in routine clinical workup...
- Metabolic imbalance associated with methylation dysregulation and oxidative damage in children with autismStepan Melnyk
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
J Autism Dev Disord 42:367-77. 2012..Further, these results suggest a plausible mechanism by which pro-oxidant environmental stressors may modulate genetic predisposition to autism...
- Relative burden of large CNVs on a range of neurodevelopmental phenotypesSanthosh Girirajan
Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington, United States of America
PLoS Genet 7:e1002334. 2011..When autism without ID was considered separately, the increase in CNV burden was modest compared to controls (p = 0.07, odds ratio = 2.33)...
- Abnormal ventral temporal cortical activity during face discrimination among individuals with autism and Asperger syndromeR T Schultz
Child Study Center, Yale University, New Haven, Conn 06520 7900, USA
Arch Gen Psychiatry 57:331-40. 2000..Therefore, it is of considerable interest that individuals with autism and related conditions have selective deficits in face recognition (sparing nonface object recognition)...
- Global prevalence of autism and other pervasive developmental disordersMayada Elsabbagh
Department of Psychiatry, Montreal Children s Hospital, Montreal, Canada Birkbeck, University of London, London, UK
Autism Res 5:160-79. 2012We provide a systematic review of epidemiological surveys of autistic disorder and pervasive developmental disorders (PDDs) worldwide...
- The social motivation theory of autismCoralie Chevallier
Center for Autism Research, Children s Hospital of Philadelphia, 3535 Market Street, Philadelphia, PA 19104, USA
Trends Cogn Sci 16:231-9. 2012..We conclude that ASD can be construed as an extreme case of diminished social motivation and, as such, provides a powerful model to understand humans' intrinsic drive to seek acceptance and avoid rejection...
- Evidence of brain overgrowth in the first year of life in autismEric Courchesne
Department of Neuroscience, School of Medicine, University of California, San Diego, La Jolla, USA
JAMA 290:337-44. 2003..This raises the possibility that brain overgrowth begins much earlier, perhaps before the first clinically noticeable behavioral symptoms...
- Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autismStephane Jamain
Laboratoire de génétique humaine et fonctions cognitives, Universite Paris 7, Institut National de la Santé et la Recherche Médicale E0021, 75015 Paris, France
Nat Genet 34:27-9. 2003..These mutations affect cell-adhesion molecules localized at the synapse and suggest that a defect of synaptogenesis may predispose to autism...
- Levels of emotional awareness and autism: an fMRI studyGiorgia Silani
University College London, London, UK
Soc Neurosci 3:97-112. 2008....
- Early social attention impairments in autism: social orienting, joint attention, and attention to distressGeraldine Dawson
Department of Psychology, Center on Human Development and Disability, University of Washington, Seattle, WA, USA
Dev Psychol 40:271-83. 2004..These results help to clarify the nature of social attention impairments in autism, offer clues to developmental mechanisms, and suggest targets for early intervention...
- When the social mirror breaks: deficits in automatic, but not voluntary, mimicry of emotional facial expressions in autismDaniel N McIntosh
Department of Psychology, University of Denver, CO 80208, USA
Dev Sci 9:295-302. 2006..The data suggest that autism is associated with an impairment of a basic automatic social-emotion process. Results have implications for understanding typical and atypical social cognition...
- Two-year-olds with autism orient to non-social contingencies rather than biological motionAmi Klin
Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06519 1124, USA
Nature 459:257-61. 2009..This observation has far-reaching implications for understanding the altered neurodevelopmental trajectory of brain specialization in autism...
- White matter structure in autism: preliminary evidence from diffusion tensor imagingNaama Barnea-Goraly
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA
Biol Psychiatry 55:323-6. 2004..Prior studies have suggested that abnormal connections between brain regions important for social cognition may contribute to the social deficits seen in autism...
- Unusual brain growth patterns in early life in patients with autistic disorder: an MRI studyE Courchesne
Department of Neuroscience, School of Medicine, University of California, San Diego, La Jolla, USA
Neurology 57:245-54. 2001..To quantify developmental abnormalities in cerebral and cerebellar volume in autism...
- Genomic and epigenetic evidence for oxytocin receptor deficiency in autismSimon G Gregory
Duke Center for Human Genetics, DUMC, Durham, NC, USA
BMC Med 7:62. 2009..Although numerous approaches have been used to identify genes implicated in the development of autism, less than 10% of autism cases have been attributed to single gene disorders...
- The amygdala theory of autismS Baron-Cohen
Departments of Experimental Psychology and Psychiatry, University of Cambridge, Downing Street, Cambridge, UK
Neurosci Biobehav Rev 24:355-64. 2000..The amygdala is therefore proposed to be one of several neural regions that are abnormal in autism. We conclude that the amygdala theory of autism contains promise and suggest some new lines of research...
- Elevated cytokine levels in children with autism spectrum disorderCynthia A Molloy
Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, United States
J Neuroimmunol 172:198-205. 2006..Cases had significantly higher IL-13/IL-10 and IFN-gamma/IL-10 than controls...
- Glutamic acid decarboxylase 65 and 67 kDa proteins are reduced in autistic parietal and cerebellar corticesS Hossein Fatemi
Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware Street SE, Mayo Building, Box 392, Minneapolis, MN 55455, USA
Biol Psychiatry 52:805-10. 2002..To further investigate these studies, brain levels of rate limiting enzyme, glutamic acid decarboxylase, which is responsible for normal conversion of glutamate to gamma amino butyric acid in the brain, were investigated...
- A big-world network in ASD: dynamical connectivity analysis reflects a deficit in long-range connections and an excess of short-range connectionsPablo Barttfeld
Integrative Neuroscience Laboratory, Physics Department, University of Buenos Aires, Buenos Aires, Argentina
Neuropsychologia 49:254-63. 2011..Together these results show that delta-band coherence reveal qualitative and quantitative aspects associated with ASD pathology...
- Visual scanning of faces in autismKevin A Pelphrey
Department of Psychology, UNC Neurodevelopmental Disorders Research Center, University of North Carolina at Chapel Hill, NC, USA
J Autism Dev Disord 32:249-61. 2002..Collectively, these results indicate disorganized processing of face stimuli in autistic individuals and suggest a mechanism that may subserve the social information processing deficits that characterize autism spectrum disorders...
- The genetics of child psychiatric disorders: focus on autism and Tourette syndromeMatthew W State
Department of Child Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
Neuron 68:254-69. 2010....
- Diffusion tensor imaging of the corpus callosum in AutismAndrew L Alexander
Department of Medical Physics, University of Wisconsin, Madison, WI, USA
Neuroimage 34:61-73. 2007..These results suggest that the microstructure of the corpus callosum is affected in autism, which may be related to nonverbal cognitive performance...
- Functional connectivity in a baseline resting-state network in autismVladimir L Cherkassky
Center for Cognitive Brain Imaging, Department of Psychology, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
Neuroreport 17:1687-90. 2006..This functional underconnectivity was observed in the anterior-posterior connections. The results expand the theory of cortical underconnectivity in autism to the resting state of the brain...
- Toward fulfilling the promise of molecular medicine in fragile X syndromeDilja D Krueger
The Picower Institute for Learning and Memory, Howard Hughes Medical Institute, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Annu Rev Med 62:411-29. 2011..The insights gained from FXS and other autism-related single-gene disorders may also assist in identifying molecular mechanisms and potential treatment approaches for idiopathic autism...
- Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorderNanda N J Rommelse
Department of Psychiatry, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Center, Reinier Postlaan 10, Nijmegen, The Netherlands
Eur Child Adolesc Psychiatry 19:281-95. 2010..Multivariate multi-level models are probably best suited for the statistical analysis...
- Prevalence of autism-spectrum conditions: UK school-based population studySimon Baron-Cohen
University of Cambridge, Autism Research Centre, Department of Psychiatry, Douglas House, 18b Trumpington Road, Cambridge CB2 8AH, UK
Br J Psychiatry 194:500-9. 2009..Recent reports estimate the prevalence of autism-spectrum conditions in the UK to be 1%...
- Epidemiology of pervasive developmental disordersEric Fombonne
Department of Psychiatry, Montreal Children s Hospital of the McGill University Health Centre, Montreal, Quebec, Canada
Pediatr Res 65:591-8. 2009..since 1966 that provided estimates for the prevalence of pervasive developmental disorders (PDDs), including autistic disorder, Asperger disorder, PDD not otherwise specified, and childhood disintegrative disorder...
- Behavioural phenotyping assays for mouse models of autismJill L Silverman
National Institute of Mental Health, Porter Neuroscience Research Center, Bethesda, MD 20892 3730, USA
Nat Rev Neurosci 11:490-502. 2010..Robust phenotypes in mouse models hold great promise as translational tools for discovering effective treatments for components of autism spectrum disorders...
- Autism, Asperger syndrome and brain mechanisms for the attribution of mental states to animated shapesFulvia Castelli
Institute of Cognitive Neuroscience, University College London, UK
Brain 125:1839-49. 2002..This finding suggests a physiological cause for the mentalizing dysfunction in autism: a bottleneck in the interaction between higher order and lower order perceptual processes...
- AutismSusan E Levy
Children s Hospital of Philadelphia, University of Pennsylvania, School of Medicine, Center for Autism Research, Philadelphia, PA 19104, USA
Lancet 374:1627-38. 2009..Further knowledge about early identification, neurobiology of autism, effective treatments, and the effect of this disorder on families is needed...
- Identification and evaluation of children with autism spectrum disordersChris Plauché Johnson
Pediatrics 120:1183-215. 2007....
- Copy-number variations associated with neuropsychiatric conditionsEdwin H Cook
Institute for Juvenile Research, Department of Psychiatry, University of Illinois, 1747 West Roosevelt Road, Chicago, Illinois 60608, USA
Nature 455:919-23. 2008..The complexity of neuropsychiatric genetics, however, dictates that assessment of the biomedical relevance of copy-number variants and the genes that they affect needs to be considered in an integrated context...
- The role of immune dysfunction in the pathophysiology of autismCharity Onore
Department of Medical Microbiology and Immunology, University of California, Davis, CA, USA
Brain Behav Immun 26:383-92. 2012....
- The epidemiology of autism spectrum disordersCraig J Newschaffer
Department of Epidemiology and Biostatistics, Drexel University School of Public Health, Philadelphia, PA 19102, USA
Annu Rev Public Health 28:235-58. 2007....
- Getting answers from babies about autismMayada Elsabbagh
Centre for Brain and Cognitive Development, Birkbeck, University of London, Henry Wellcome Building, London, WC1E 7HX, UK
Trends Cogn Sci 14:81-7. 2010..As the search for early markers continues, infants at-risk present a persuasive model for gene by environment interactions leading to variable developmental pathways...
- Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autismS Jill James
Department of Pediatrics, University of Arkansas for Medical Sciences, and the Arkansas Children s Hospital Research Institute, Little Rock, AR 72202, USA
Am J Clin Nutr 80:1611-7. 2004..Although abnormal metabolism of methionine and homocysteine has been associated with other neurologic diseases, these pathways have not been evaluated in persons with autism...
- Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autismS Jill James
Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children s Hospital Research Institute, 1120 Marshall St, Little Rock, AR 72202, USA
FASEB J 23:2374-83. 2009..These results suggest that the autism LCLs exhibit a reduced glutathione reserve capacity in both cytosol and mitochondria that may compromise antioxidant defense and detoxification capacity under prooxidant conditions...
- SYN1 loss-of-function mutations in autism and partial epilepsy cause impaired synaptic functionAnna Fassio
Department of Experimental Medicine, National Institute of Neuroscience, University of Genova, Viale Benedetto XV 3, 16132 Genova, Italy
Hum Mol Genet 20:2297-307. 2011..These results demonstrate that SYN1 is a novel predisposing gene to ASDs, in addition to epilepsy, and strengthen the hypothesis that a disturbance of synaptic homeostasis underlies the pathogenesis of both diseases...
- Early brain overgrowth in autism associated with an increase in cortical surface area before age 2 yearsHeather Cody Hazlett
Department of Psychiatry, The Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, NC 27599, USA
Arch Gen Psychiatry 68:467-76. 2011..Brain enlargement has been observed in 2-year-old children with autism, but the underlying mechanisms are unknown...
- Mitochondrial dysfunction in autismCecilia Giulivi
University of California, School of Veterinary Medicine, Department of Molecular Biosciences, One Shields Avenue, 1120 Haring Hall, Davis, CA 95616, USA
JAMA 304:2389-96. 2010..No studies have evaluated mitochondrial dysfunction and mitochondrial DNA (mtDNA) abnormalities in a well-defined population of children with autism...
- Short-term benefit from oral vancomycin treatment of regressive-onset autismR H Sandler
Section of Pediatric Gastroenterology and Nutrition, Rush Children s Hospital, Rush Medical College, Chicago, IL 60612, USA
J Child Neurol 15:429-35. 2000....
- Prevalence of serum antibodies to caudate nucleus in autistic childrenVijendra K Singh
Department of Biology, Biotechnology Center Building, Utah State University, 4700 Old Main Hill, Logan, UT 84322 4700, USA
Neurosci Lett 355:53-6. 2004..Thus, the caudate nucleus might be involved in the neurobiology of autism...
- Common genetic variants on 5p14.1 associate with autism spectrum disordersKai Wang
Center for Applied Genomics, Children s Hospital of Philadelphia, Pennsylvania 19104, USA
Nature 459:528-33. 2009..Our results implicate neuronal cell-adhesion molecules in the pathogenesis of ASDs, and represent, to our knowledge, the first demonstration of genome-wide significant association of common variants with susceptibility to ASDs...
- Validation of a brief quantitative measure of autistic traits: comparison of the social responsiveness scale with the autism diagnostic interview-revisedJohn N Constantino
Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
J Autism Dev Disord 33:427-33. 2003..Q. and exhibited inter-rater reliability on the order of 0.8. The SRS is a valid quantitative measure of autistic traits, feasible for use in clinical settings and for large-scale research studies of autism spectrum conditions...
- The genetics of autism: key issues, recent findings, and clinical implicationsPaul El-Fishawy
Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
Psychiatr Clin North Am 33:83-105. 2010..This article reviews the origins of the common versus rare variant debate, highlights recent findings in the field, and addresses the clinical implications of common and rare variant discoveries...
- Metabolic biomarkers related to oxidative stress and antioxidant status in Saudi autistic childrenY Al-Gadani
Biochemistry Department, Science College, King Saud University, PO Box 22452, Zip code 11495, Riyadh, Saudi Arabia
Clin Biochem 42:1032-40. 2009..Measurement of oxidative stress and antioxidant-related parameters (enzymatic and non-enzymatic) in Saudi autistic children...
- Sex differences in the brain: implications for explaining autismSimon Baron-Cohen
Autism Research Centre, Cambridge University, Department of Psychiatry, Douglas House, 18b Trumpington Road, Cambridge CB2 2AH, UK
Science 310:819-23. 2005..Here we suggest that specific aspects of autistic neuroanatomy may also be extremes of typical male neuroanatomy...
- Oxidative stress in Egyptian children with autism: relation to autoimmunityGehan A Mostafa
Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt
J Neuroimmunol 219:114-8. 2010..5% of autistic children, (odds ratio: 12.38 and 6.43, respectively, confidence interval: 1.37-112.10 and 1.21-34.19, respectively)...
- Glutamate receptor recruitment to new synapses in vivoPHILIP ERIC WASHBOURNE; Fiscal Year: 2013..Our research will help understand the mechanisms by which synapses form and bring us closer to identifying the molecular deficits in individuals with autism and mental retardation. ..
- Chemical modulators of Tet-family proteinsAnjana Rao; Fiscal Year: 2010..These molecules will be useful for further investigations into the biological functions of TET proteins, and may eventually be used in the clinic to treat Rett syndrome and other diseases of DNA methylation. ..
- Environmental Risk Factors for Copy Number Variation in Human ChromosomesTHOMAS EDWARD WILSON; Fiscal Year: 2010....
- Mechanisms of Bone Loss from Administration of the Second-Generation AntipsychotiKATHERINE JEAN MOTYL; Fiscal Year: 2013..My results will also add to the increasing evidence for a key role of the nervous system in regulating skeletal homeostasis. ..
- A Computational Framework for Mapping Long Range Genetic CircuitsTolga Tasdizen; Fiscal Year: 2010..This knowledge will provide insights into new drug targets to prevent, treat, and ultimately cure mental illness. ..
- KINETICS OF DRUG MACROMOLECULE COMPLEX FORMATIONPALMER WILLIAM TAYLOR; Fiscal Year: 2013....
- Serotonin transporter-mediated regulation of neuroendocrine exocytosisKEVIN P CURRIE; Fiscal Year: 2013..This will provide the foundation for future expanded applications to investigate a new paradigm for 5HT / SERT mediated signal transduction. ..
- Ephrin-A3 in Neuron-Glia CommunicationElena B Pasquale; Fiscal Year: 2011..Strategies to manipulate ephrin function in glial cells could help treatment of neurological disorders involving aberrant neuron-glia interactions in the hippocampus and other regions of the nervous system. ..
- Connexins in Neuronal and Glial Gap Junctions in the Central Nervous SystemJohn E Rash; Fiscal Year: 2012..normal human cerebral cortex and hippocampus. These data will serve as a prelude to measuring changes in these structures in human disease such as epilepsy, schizophrenia, Parkinson's disease, and autism spectral disorders. ..
- Epidemiological Research on Autism in JamaicaMohammad H Rahbar; Fiscal Year: 2010....
- Derivation of cerebral cortical GABAergic interneurons from human iPS cellsLorenz P Studer; Fiscal Year: 2010....
- Molecular physiology of voltage-gated Ca2+ channelsJian Yang; Fiscal Year: 2013..By studying a novel form of activity-dependent fragmentation of VGCCs on the cell membrane, this work may lead to a better understanding of VGCC function and regulation in physiological and pathological conditions. ..
- Serotonin, Autism, and investigating cell types for CNS disorders.Joseph D Dougherty; Fiscal Year: 2010..The approach proposed here has the potential to provide those cellular targets for treatments. ..
- In vivo targeted gene silencing, a novel methodWILLIAM ANTHONY TRUITT; Fiscal Year: 2012..To overcome this problem we plan to develop a novel method of in vivo targeted delivery of PNAs and demonstrate the feasibility of using these compounds in an animal model. ..
- Analysis of the tumor suppressor gene Tsc1 in motor neuron patterningOnanong Chivatakarn; Fiscal Year: 2013....
- Chemical approaches for studying the biology of CD38Hening Lin; Fiscal Year: 2013..Our proposed study will help to understand the roles of CD38 plays in normal and pathological conditions, and potentially lead to new ways to treat human diseases involving CD38. ..
- Developmental Regulation of Brain and BehaviorJULI S WADE; Fiscal Year: 2011....
- Epidemiological Research on Autism in Jamaica - Phase IIMohammad H Rahbar; Fiscal Year: 2013....
- Function and Structure Adaptations in Forebrain DevelopmentPAT R LEVITT; Fiscal Year: 2013..This project includes basic and clinical translational studies that will provide insight into gene- gene and gene-environment interactions that may underlie atypical brain functions in ASD. ..
- Development and Regulation of Cholinergic SynapsesAndres Villu Maricq; Fiscal Year: 2013....
- Epigenome Mapping in Cortical InterneuronsSchahram Akbarian; Fiscal Year: 2013....
- Subunit dependent properties of kainate receptorsDavid D Mott; Fiscal Year: 2013..A better understanding of kainate receptor properties is essential in the rational development of novel therapeutic agents targeted at these receptors. ..
- Mechanisms and Therapeutics for Rett SyndromeMriganka Sur; Fiscal Year: 2013..Since IGF1 is FDA-approved for clinical use in children with growth failure, this study represents a valid approach for a therapeutic intervention on RTT patients. ..
- Activity-dependent phosphorylation of MeCP2DANIEL HIGGINS EBERT; Fiscal Year: 2013..Improved understanding of the mechanism of MeCP2 function may guide the development of new treatments for these disorders in the future. ..
- NATIONAL CHILDREN'S STUDY SUPPORTBetty Wood; Fiscal Year: 2012..Study researchers seek to enroll prospective mothers to start this large observational study. ..
- NATIONAL CHILDREN'S STUDY SUPPORTBetty Wood; Fiscal Year: 2011..Study researchers seek to enroll prospective mothers to start this large observational study. ..
- NATIONAL CHILDREN'S STUDY -CLINICAL BIOLOGICAL ANALYSISVELAZQUEZ FRANCISCO; Fiscal Year: 2011..Study researchers seek to enroll prospective mothers to start this large observational study. ..
- NATIONAL CHILDREN'S STUDY SUPPORTBetty Wood; Fiscal Year: 2013..Study researchers seek to enroll prospective mothers to start this large observational study. ..
- microRNA analysis of neurons generated from patient-specific iPSCsHerbert M Lachman; Fiscal Year: 2013..Such common pathways would be ideal targets for medication development that could be effective in a large subgroup of patients. ..
- Functionally Significant Polymorphisms in Serotonin Pathway GenesBeverly H Koller; Fiscal Year: 2010..These mice can be used to study the impact of this polymorphism on gene expression, protein function, development, and on the behavioral tests/models known to be sensitive to alterations in this specific pathway in rodents. ..
- Regulation of 22q11 Genes in Embroyonic and Adult ForebrainAnthony S LaMantia; Fiscal Year: 2013..Thus, our studies help explain how a specific mutation can lead to changes in brain development and function that may underlie autism, mental retardation, ADHD, mood disorders and schizophrenia. ..
- MRDD Research CenterKARL PFENNINGER; Fiscal Year: 2009..Strategic planning has led the investigators to initiate a series of hires, principally in basic neurosciences, and has led to considerable enhancement of cores. ..
- Identifying Biomarkers for Post-Partum Depression in African-American WomenPatrick F Sullivan; Fiscal Year: 2013..Future research could evaluate whether a biomarker signature is of predictive utility and, if so, rational primary prevention may become feasible. ..
- Genetic Interactions and Synthetic Population BiologyMichael B Elowitz; Fiscal Year: 2013..These fundamental issues are critical for understanding the link between population genetics and the observed complex disease phenotypes, and are thus central to the development of genomic medicine. ..
- The Role of Alternative Splicing Factor Sfrs10 in Neural DevelopmentRahul N Kanadia; Fiscal Year: 2010....
- Thyroid hormone-dependent DNA methylation in the developing brainYasuhiro Kyono; Fiscal Year: 2012..Such understanding can contribute to the prevention, diagnosis and treatment of human neurological conditions such as mental retardation, autism spectrum disorder and schizophrenia. ..
- Structural determinants of DTI observations in developing cortex and white matterChristopher D Kroenke; Fiscal Year: 2013..We will also use this experimental strategy to expand the capabilities of MRI to studies of earlier stages of brain development. ..
- Genetic Regulation of Rhombomere FormationCHARLES G SAGERSTROM; Fiscal Year: 2013..g. hematopoiesis). The results from our proposed experiments will therefore be applicable to a broad set of biological processes and human disease conditions. ..
- CRCNS: Gamma Rhythms and Cell AssembliesNancy Kopell; Fiscal Year: 2013..Finally, the specific project will also help train two graduate students and a postdoctoral fellow. ..
- Molecular and cellular mechanism of MicrocephalyArnold Kriegstein; Fiscal Year: 2013....
- DETERMINATION OF NEURONAL FATES IN VISUAL CORTEXSusan K McConnell; Fiscal Year: 2013..The goals of our research are to identify the genes that regulate neurogenesis in the visual cortex and to understand how they affect the formation of cortical circuitry. ..
- Experience-Dependent Redeployment of MeCP2 Across the Mouse GenomeQiang Chang; Fiscal Year: 2011..Furthermore, because of the considerable overlap in clinical features between RTT and autistic spectrum disorders, the lessons learned studying RTT might also benefit the general understanding of autism. ..
- CRCNS: Theory and experiment of neural circuit mapping by DNA sequencingAnthony M Zador; Fiscal Year: 2013..It is hard, if not impossible, to identify a medical condition involving the nervous system that would not affect neuronal connections. ..
- Environmental and genetic regulation of copy number variation (CNV)THOMAS PETES; Fiscal Year: 2010..During the past few years, it has become increasingly clear that copy number variation (CNV) is associated with many human diseases. Thus, factors that elevate the rate of CNV are likely to elevate the frequency of those diseases. ..
- 2012 Fragile X and Autism-Related Disorders: From Basic Neuroscience to ImprovedELIZABETH MARA BERRY-KRAVIS; Fiscal Year: 2012....
- Epidemiology of testicular cancer in the Utah populationMia Hashibe; Fiscal Year: 2012..We will also study the prognosis of testicular cancer patients and examine what factors affect prognosis. Our results will be relevant for public health planning of prevention efforts against testicular cancer in Utah. ..
- Longitudinal Studies of Autism Spectrum Disorders: 2 to 23Catherine Lord; Fiscal Year: 2012..This project will provide information that will be useful in developing new ways to improve quality of life for individuals with ASD and their families. ..
- Aptamer probes for Epigenetic Peptide TargetsMARK PATRICK MCPIKE; Fiscal Year: 2010..Unlike genetic aberrations, epigenetic changes are potentially reversible by modulating the activities of the enzymes that stabilize or remodel the packing of DNA in chromosomes. ..
- Foxp2 regulation of sex specific transcriptional pathways and brain developmentJERALD MICHAEL BOWERS; Fiscal Year: 2013..For the R00 phase, I will write up the research collected from Aims 1.2 and Aims 2.1 and 2.1. I will then begin setting up my lab. Concurrent with opening the lab, I will begin work on Aim 3. ..
- RAX, PKR and ethanol neurotoxicityGang Chen; Fiscal Year: 2013..Specific Aim 3: To determine whether RAX+/- mice, N-PKR-/- mice or PKR-inhibitor-injected mice are more resistant to ethanol-induced cerebellar behavioral dysfunction. ..
- NATIONAL CHILDREN'S STUDYWilliam Hogan; Fiscal Year: 2013..The Study is the largest long-term study of children's health ever conducted in the United States. Specific Aims: ..
- Novel lead molecule optimization targeting nicotinic receptor subtypesDENNIS BRIAN contact MCKAY; Fiscal Year: 2010....
- SUPPORT OF THE NATIONAL CHILDREN'S STUDY INFORMATION SYSTEMJAMES TER MAAT; Fiscal Year: 2012..The National Children's Study has initiated recruitment at 30 study locations around the United States. The Study is the largest long-term study of children's health ever conducted in the United States. ..
- NATIONAL CHILDREN'S STUDYDANA DABALEA; Fiscal Year: 2012..The National Children's Study has initiated recruitment at 30 study locations around the United States. The Study is the largest long-term study of children's health ever conducted in the United States. ..
- NATIONAL CHILDREN'S STUDY BIOMEDICAL (APPLIED/EXPLORATORY)Lee Smith; Fiscal Year: 2012..The National Children's Study has initiated recruitment at 30 study locations around the United States. The Study is the largest long-term study of children's health ever conducted in the United States. ..
- NATIONAL CHILDREN'S STUDYHelen Koo; Fiscal Year: 2013
- NATIONAL CHILDREN'S STUDYHelen Koo; Fiscal Year: 2012
- NATIONAL CHILDREN'S STUDYKristina Lewis; Fiscal Year: 2013
- GUIDING VISUAL ATTENTION TO ENHANCE DISCRIMINATION LEARNINGMichael T Carlin; Fiscal Year: 2011..Existing literature, though limited, implies that these populations would be expected to perform quite differently on these tasks. Further, our use of reaction time (RT) and eye-tracking measures of ..
- DEFINITION AND DEVELOPMENT OF THE PHENOTYPE IN AUTISMSally Rogers; Fiscal Year: 2001....
- Pupil Size and Circadian Salivary Variations in Autism Spectrum DisorderJOHN A COLOMBO; Fiscal Year: 2010....
- GENOTYPE AND PHENOTYPE OF BRAINSTEM INJURY IN AUTISMPatricia Rodier; Fiscal Year: 2002..The goal is to determine whether the phenotypic or genotypic features of these disorders indicate a common etiology. ..
- RNA-Seq studies of Gene Expression in Cells and Networks in FI and ACC in AutismBarbara J Wold; Fiscal Year: 2010..We propose to use laser micro-dissection to investigate gene expression in specific neuronal and non-neuronal populations in the cortical areas of interest in the autism-A, autism-B and control groups. ..
- Improving and Streamlining Screening and Diagnosis of ASD at 18-24 Months of AgeAmy M Wetherby; Fiscal Year: 2010..By improving and streamlining early screening and diagnosis of ASD in 18 to 24 month old children, the findings of this study will have important implications for earlier access to intervention. ..
- GENOTYPE AND PHENOTYPE OF BRAINSTEM INJURY IN AUTISMPatricia Rodier; Fiscal Year: 2007..This project is closely related to the gene-environment studies proposed in animals. ..
- TrkB Agonist(s), a Potential Therapy for Autism Spectrum DisordersYi Eve Sun; Fiscal Year: 2010..In this application, we hypothesize that activation of BDNF signaling through small molecule TrkB agonist(s) may benefit not only RTT but also other ASDs. ..
- Genetic Susceptibility to Mercury-Induced Immune Dysfunction in Autism & ASDEllen Silbergeld; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Treatment as usual and peer engagement in teens with High Functioning AutismFelice Orlich; Fiscal Year: 2010..and related disorders may be as high as 1 in 150 children with nationwide estimates of the overall costs of Autistic disorder to society approaching $90 billion;with nearly 90% of those costs in adult services...
- High-resolution diffusion tensor imaging in mouse models relevant to autismHarish Poptani; Fiscal Year: 2010....
- A Sex-Specific Dissection of Autism GeneticsLAUREN ANNE WEISS; Fiscal Year: 2010..With better understanding of the biological basis and the genetic architecture of autism, diagnosis, prognosis, prevention and treatment options could be improved. ..
- Community Skills Video Game for Children with AutismAMY MAGUIRE; Fiscal Year: 2005..Social relevance to parents and professionals will be examined with a survey. This Phase I feasibility study will provide the foundation for Phase II evaluation of outcomes across a greater number of skills and participants. ..
- Eyeblink in Children and Adolescents with Autism Spectrum Disorders:A Pilot StudyRichard P Malone; Fiscal Year: 2010..Welsh, Ph.D.) and a clinical researcher (Richard P. Malone, M.D.) so that knowledge gained in the basic science laboratory can be used to further investigate causes of symptomology in individuals with ASD. ..
- GENETIC INFLUENCES IN AUTISM AND TUBEROUS SCLEROSISSusan Smalley; Fiscal Year: 1993..In addition to these sub-clinical behavioral and biological measures, the frequency of DSMIII diagnosed autism and autistic-like behaviors will be determined in the tuberous sclerosis subjects, autistic subjects, and their relatives...
- Social Skills Intervention for Adolescents with High Functioning Autism/AspergerDorothy Strickland; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..