pervasive child development disorders

Summary

Summary: Severe distortions in the development of many basic psychological functions that are not normal for any stage in development. These distortions are manifested in sustained social impairment, speech abnormalities, and peculiar motor movements.

Top Publications

  1. pmc Mutation screening of melatonin-related genes in patients with autism spectrum disorders
    Lina Jonsson
    Institute of Neuroscience and Physiology, Department of Pharmacology, Gothenburg University, Sweden
    BMC Med Genomics 3:10. 2010
  2. ncbi Intergenerational transmission of subthreshold autistic traits in the general population
    John N Constantino
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Biol Psychiatry 57:655-60. 2005
  3. ncbi Multiple complex developmental disorder: the "multiple and complex" evolution of the "childhood borderline syndrome" construct
    Y Ad-Dab'bagh
    Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    J Am Acad Child Adolesc Psychiatry 40:954-64. 2001
  4. ncbi The Autism Diagnostic Observation Schedule: revised algorithms for improved diagnostic validity
    Katherine Gotham
    University of Michigan Autism and Communication Disorders Center, Ann Arbor, MI, 48109 2054, USA
    J Autism Dev Disord 37:613-27. 2007
  5. ncbi Validation of a brief quantitative measure of autistic traits: comparison of the social responsiveness scale with the autism diagnostic interview-revised
    John N Constantino
    Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Autism Dev Disord 33:427-33. 2003
  6. ncbi Pervasive developmental disorders in preschool children: confirmation of high prevalence
    Suniti Chakrabarti
    Child Development Centre, Central Clinic, Stafford, UK
    Am J Psychiatry 162:1133-41. 2005
  7. ncbi Diagnostic rules for children with PDD-NOS and multiple complex developmental disorder
    J K Buitelaar
    Department of Child Psychiatry and the Rudolph Magnus Institute for Neurosciences, Utrecht, The Netherlands
    J Child Psychol Psychiatry 39:911-9. 1998
  8. ncbi Verbal memory and Performance IQ predict theory of mind and emotion recognition ability in children with autistic spectrum disorders and in psychiatric control children
    J K Buitelaar
    Department of Child and Adolescent Psychiatry and Rudolf Magnus Institute for Neurosciences, University of Utrecht, The Netherlands
    J Child Psychol Psychiatry 40:869-81. 1999
  9. ncbi Face recognition in children with a pervasive developmental disorder not otherwise specified
    M Serra
    Academic Centre for Child and Adolescent Psychiatry, Groningen, The Netherlands
    J Autism Dev Disord 33:303-17. 2003
  10. ncbi Pervasive developmental disorders in preschool children
    S Chakrabarti
    MRC Child Psychiatry Unit, Institute of Psychiatry/King's College London, Denmark Hill, London SE5 8AF, England
    JAMA 285:3093-9. 2001

Research Grants

  1. METHYLPHENIDATE TREATMENT OF ADHD IN CHILDREN WITH TS
    Kenneth Gadow; Fiscal Year: 2004
  2. Psychopharmacology of Autism and related Disorders
    David Posey; Fiscal Year: 2007
  3. Anger Control Training for Youth with Tourette Syndrome
    Larry Scahill; Fiscal Year: 2005
  4. RUPP-PI Program at Yale University
    Lawrence Scahill; Fiscal Year: 2006
  5. Behavior Therapy for Adults with Tourette Syndrome
    Lawrence Scahill; Fiscal Year: 2009
  6. A QUANTITATIVE GENETIC MEASURE OF AUTISTIC TRAITS
    John Constantino; Fiscal Year: 2002
  7. RUPP-PI
    Christopher McDougle; Fiscal Year: 2006
  8. Prenatal Exposure to Polyfluoroalkyl Compounds in the EMA Study
    Lisa A Croen; Fiscal Year: 2010
  9. UW Autism Research Center of Excellence
    Elizabeth Aylward; Fiscal Year: 2007
  10. NEUROBIOLOGY AND GENETICS OF AUTISM
    Geraldine Dawson; Fiscal Year: 2006

Detail Information

Publications206 found, 100 shown here

  1. pmc Mutation screening of melatonin-related genes in patients with autism spectrum disorders
    Lina Jonsson
    Institute of Neuroscience and Physiology, Department of Pharmacology, Gothenburg University, Sweden
    BMC Med Genomics 3:10. 2010
    ....
  2. ncbi Intergenerational transmission of subthreshold autistic traits in the general population
    John N Constantino
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Biol Psychiatry 57:655-60. 2005
    ..Subthreshold autistic social impairments are known to aggregate in the family members of autistic probands; therefore, we conducted this study to examine the intergenerational transmission of such traits in the general population...
  3. ncbi Multiple complex developmental disorder: the "multiple and complex" evolution of the "childhood borderline syndrome" construct
    Y Ad-Dab'bagh
    Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    J Am Acad Child Adolesc Psychiatry 40:954-64. 2001
    ..To provide an overview of the history, evolution, and nosology of the diagnostic constructs for "borderline syndrome of childhood," also known as "multiple complex developmental disorder."..
  4. ncbi The Autism Diagnostic Observation Schedule: revised algorithms for improved diagnostic validity
    Katherine Gotham
    University of Michigan Autism and Communication Disorders Center, Ann Arbor, MI, 48109 2054, USA
    J Autism Dev Disord 37:613-27. 2007
    ....
  5. ncbi Validation of a brief quantitative measure of autistic traits: comparison of the social responsiveness scale with the autism diagnostic interview-revised
    John N Constantino
    Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Autism Dev Disord 33:427-33. 2003
    ..Q. and exhibited inter-rater reliability on the order of 0.8. The SRS is a valid quantitative measure of autistic traits, feasible for use in clinical settings and for large-scale research studies of autism spectrum conditions...
  6. ncbi Pervasive developmental disorders in preschool children: confirmation of high prevalence
    Suniti Chakrabarti
    Child Development Centre, Central Clinic, Stafford, UK
    Am J Psychiatry 162:1133-41. 2005
    ..6 per 10,000 in a previous study of preschoolers in Stafford, U.K. They conducted another survey in 2002 to estimate the prevalence in children in a later birth cohort and to compare it to previous findings from the same area...
  7. ncbi Diagnostic rules for children with PDD-NOS and multiple complex developmental disorder
    J K Buitelaar
    Department of Child Psychiatry and the Rudolph Magnus Institute for Neurosciences, Utrecht, The Netherlands
    J Child Psychol Psychiatry 39:911-9. 1998
    ..The most effective and simple rule based on McDD criteria had a cut-off of three items, out of six items of anxieties and thought disturbance...
  8. ncbi Verbal memory and Performance IQ predict theory of mind and emotion recognition ability in children with autistic spectrum disorders and in psychiatric control children
    J K Buitelaar
    Department of Child and Adolescent Psychiatry and Rudolf Magnus Institute for Neurosciences, University of Utrecht, The Netherlands
    J Child Psychol Psychiatry 40:869-81. 1999
    ..Overall, the results of the various analyses converged and indicated that verbal memory, Performance IQ, age and gender were the best predictors of social cognitive ability...
  9. ncbi Face recognition in children with a pervasive developmental disorder not otherwise specified
    M Serra
    Academic Centre for Child and Adolescent Psychiatry, Groningen, The Netherlands
    J Autism Dev Disord 33:303-17. 2003
    ..The results are discussed in the light of a theory that explains the development of coherent mental representations...
  10. ncbi Pervasive developmental disorders in preschool children
    S Chakrabarti
    MRC Child Psychiatry Unit, Institute of Psychiatry/King's College London, Denmark Hill, London SE5 8AF, England
    JAMA 285:3093-9. 2001
    ..Attention is nevertheless drawn to the important needs of a substantial minority of preschool children...
  11. ncbi Thimerosal-containing vaccines and autistic spectrum disorder: a critical review of published original data
    Sarah K Parker
    Department of Pediatrics, Children s Hospital and University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Pediatrics 114:793-804. 2004
    ....
  12. ncbi Epidemiological surveys of autism and other pervasive developmental disorders: an update
    Eric Fombonne
    McGill University, Department of Psychiatry, The Montreal Children s Hospital, 4018 St Catherine St W, Montreal, QC H3Z 1P2, Canada
    J Autism Dev Disord 33:365-82. 2003
    ..However, available epidemiological surveys do not provide an adequate test of the hypothesis of a changing incidence of PDDs...
  13. ncbi Autism and pervasive developmental disorders
    Fred R Volkmar
    Child Study Center, Yale University, New Haven, CT 06520, USA
    J Child Psychol Psychiatry 45:135-70. 2004
    ..Significant challenges lie ahead in evaluating the growing number of treatments for autism and in integrating the results of research into treatment and educational settings...
  14. ncbi The comorbidity of Pervasive Developmental Disorder and Attention Deficit Hyperactivity Disorder: results of a retrospective chart review
    Sam Goldstein
    University of Utah, USA
    J Autism Dev Disord 34:329-39. 2004
    ..Further, do children with PDD displaying such symptoms demonstrate more impairment in daily life activities than those children only having PDD?..
  15. ncbi Increased prevalence of familial autoimmunity in probands with pervasive developmental disorders
    Thayne L Sweeten
    Department of Psychiatry, Indiana University School of Medicine, and James Whitcomb Riley Hospital for Children Indianapolis 46202 4800, USA
    Pediatrics 112:e420. 2003
    ..We further investigated this association by determining the frequency of autoimmune disorders in families that have probands with pervasive developmental disorders (PDDs), including autism, compared with 2 control groups...
  16. ncbi Efficacy of three screening instruments in the identification of autistic-spectrum disorders
    Tony Charman
    Behavioural and Brain Sciences Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Br J Psychiatry 191:554-9. 2007
    ..Screening instruments for autistic-spectrum disorders have not been compared in the same sample...
  17. ncbi Maternal and paternal age and risk of autism spectrum disorders
    Lisa A Croen
    Division of Research, Kaiser Permanente Medical Care Program, Oakland, CA 94612, USA
    Arch Pediatr Adolesc Med 161:334-40. 2007
    ..To explore the association between maternal and paternal age and risk of autism spectrum disorders (ASDs) in offspring...
  18. ncbi Randomized trial of intensive early intervention for children with pervasive developmental disorder
    T Smith
    Washington State University, USA
    Am J Ment Retard 105:269-85. 2000
    ..Children with pervasive developmental disorder NOS may have gained more than those with autism...
  19. ncbi Prevalence of pervasive developmental disorders in the British nationwide survey of child mental health
    E Fombonne
    Institute of Psychiatry, Department of Child and Adolescent Psychiatry, King s College London, England
    J Am Acad Child Adolesc Psychiatry 40:820-7. 2001
    ..The prevalence of pervasive developmental disorders (PDD) is not well established and needs monitoring. The prevalence of PDD in the 1999 nationwide British survey of child and adolescent mental health was investigated...
  20. ncbi Epidemiology of autistic disorder and other pervasive developmental disorders
    Eric Fombonne
    Department of Psychiatry, McGill University, Montreal Children s Hospital, Montreal, Quebec, Canada
    J Clin Psychiatry 66:3-8. 2005
    ..In addition, data from many of these surveys indicate correlates of autistic disorder and other PDDs with IQ, gender, and other medical disorders...
  21. ncbi 'All that glitters is not gold': misdiagnosis of psychosis in pervasive developmental disorders--a case series
    David R Dossetor
    Department of Psychological Medicine, Children s Hospital at Westmead, University of Sydney, NSW, Australia
    Clin Child Psychol Psychiatry 12:537-48. 2007
    ..It is evident that more needs to be done to improve diagnostic reliability of psychosis in PDD, by improving clinical awareness and research tools...
  22. ncbi Autism spectrum disorder in fragile X syndrome: communication, social interaction, and specific behaviors
    Walter E Kaufmann
    Kennedy Krieger Institute, Baltimore, Maryland 21211, USA
    Am J Med Genet A 129:225-34. 2004
    ..Altogether, our findings demonstrate that the diagnosis of ASD in FraX reflects, to a large extent, an impairment in social interaction that is expressed with variable severity in young males with FraX...
  23. ncbi Specifying PDD-NOS: a comparison of PDD-NOS, Asperger syndrome, and autism
    Darlene R Walker
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Am Acad Child Adolesc Psychiatry 43:172-80. 2004
    ....
  24. ncbi A population-based study of measles, mumps, and rubella vaccination and autism
    Kreesten Meldgaard Madsen
    Danish Epidemiology Science Center, Department of Epidemiology and Social Medicine, Arhus, Denmark
    N Engl J Med 347:1477-82. 2002
    ..It has been suggested that vaccination against measles, mumps, and rubella (MMR) is a cause of autism...
  25. ncbi Platelet serotonin levels in pervasive developmental disorders and mental retardation: diagnostic group differences, within-group distribution, and behavioral correlates
    Erik J Mulder
    Child and Adolescent Psychiatry Center, University of Groningen, The Netherlands
    J Am Acad Child Adolesc Psychiatry 43:491-9. 2004
    ..To investigate group differences, the within-group distributions, and the clinical correlates of platelet serotonin (5-HT) levels in pervasive developmental disorders (PDD)...
  26. pmc Array-based comparative genomic hybridisation identifies high frequency of cryptic chromosomal rearrangements in patients with syndromic autism spectrum disorders
    M L Jacquemont
    INSERM U781, Hopital Necker Enfants Malades, 149 rue de Sevres, 75015 Paris, France
    J Med Genet 43:843-9. 2006
    ..3 deletions. Many other chromosomal imbalances have been described. However, most of them remain undetectable using routine karyotype analysis, thus impeding diagnosis and genetic counselling...
  27. ncbi Pervasive developmental disorders in Montreal, Quebec, Canada: prevalence and links with immunizations
    Eric Fombonne
    Department of Psychiatry, McGill University, Montreal Children s Hospital, 4018 Ste Catherine West, Montreal, Quebec, Canada H3Z 1P2
    Pediatrics 118:e139-50. 2006
    ..The prevalence of pervasive developmental disorders has increased in recent years. Links with the measles component of the measles-mumps-rubella vaccine and the cumulative exposure to thimerosal through other vaccines have been postulated...
  28. ncbi Psychiatric symptoms in preschool children with PDD and clinic and comparison samples
    Kenneth D Gadow
    Department of Psychiatry and Behavioral Science, State University of New York, Stony Brook, 11794 8790, USA
    J Autism Dev Disord 34:379-93. 2004
    ..This study describes and compares the severity of DSM-IV symptoms in preschool children with diagnosed pervasive developmental disorder (PDD), clinic controls, and two community-based samples...
  29. ncbi Refinement of the Children's Social Behavior Questionnaire (CSBQ): an instrument that describes the diverse problems seen in milder forms of PDD
    Catharina A Hartman
    Department of Psychiatry, Faculty of Medicine, University of Groningen, 9700 RB Groningen, The Netherlands
    J Autism Dev Disord 36:325-42. 2006
    ..Estimates for internal, test-retest, and inter-rater reliability, and for convergent and divergent validity were good. Different clinical and control groups showed the hypothesized patterns in nature and degree of their problems...
  30. ncbi Effects of familial risk factors and place of birth on the risk of autism: a nationwide register-based study
    Marlene Briciet Lauritsen
    Centre for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, Aarhus University Hospital, Denmark
    J Child Psychol Psychiatry 46:963-71. 2005
    ..The etiology of autism is unknown. A strong genetic component has been detected but non-genetic factors may also be involved in the etiology...
  31. ncbi Effects of cognitive-behavioural therapy on anxiety for children with high-functioning autistic spectrum disorders
    Y P Ooi
    Department of Child and Adolescent Psychiatry, Institute of Mental Health, Child Guidance Clinic, Health Promotion Board, 3 Second Hospital Avenue 03 01, Singapore 168937
    Singapore Med J 49:215-20. 2008
    ....
  32. pmc Validation of the diagnosis of autism in general practitioner records
    Eric Fombonne
    McGill University, Montreal Children s Hospital, 4018 St Catherine St West, Montreal, QC, Canada, H3Z 1P2
    BMC Public Health 4:5. 2004
    ....
  33. ncbi Early social attention impairments in autism: social orienting, joint attention, and attention to distress
    Geraldine Dawson
    Department of Psychology, Center on Human Development and Disability, University of Washington, Seattle, WA, USA
    Dev Psychol 40:271-83. 2004
    ..These results help to clarify the nature of social attention impairments in autism, offer clues to developmental mechanisms, and suggest targets for early intervention...
  34. ncbi The broad autism phenotype: findings from an epidemiological survey
    N Micali
    Department of Child and Adolescent Psychiatry, Institute of Psychiatry, London, UK
    Autism 8:21-37. 2004
    ..PDDs were commoner in first-degree relatives. The implications of the findings for the definition of the broad phenotype of autism are discussed...
  35. ncbi Caring for Sophie. A child with pervasive refusal syndrome
    Helen Edwards
    Paediatr Nurs 16:39-42. 2004
  36. pmc Secondary medical diagnosis in fragile X syndrome with and without autism spectrum disorder
    Catalina García-Nonell
    PSYNCRON, Barcelona, Spain
    Am J Med Genet A 146:1911-6. 2008
    ..05). Medical problems that affect the CNS are more likely to occur in those with FXS + ASD and it is probable that additional brain dysfunction associated with these medical problems enhance the risk of autism in those with FXS...
  37. ncbi Prevalence and characteristics of autistic spectrum disorders in the ALSPAC cohort
    Emma Williams
    Centre for Child and Adolescent Health, University of Bristol, Bristol, UK
    Dev Med Child Neurol 50:672-7. 2008
    ..7%, epilepsy in 10.3%, and mixed developmental disorder in 4.4%. We conclude that the prevalence of ASD diagnosed at 11 years in a UK representative population-based sample is at least 51.1/10,000...
  38. pmc Advanced parental age and the risk of autism spectrum disorder
    Maureen S Durkin
    Waisman Center, University of Wisconsin School of Medicine and Public Health, 789 WARF, 610 Walnut Street, Madison, WI 53726, USA
    Am J Epidemiol 168:1268-76. 2008
    ..1, 95% confidence interval: 2.0, 4.7). The increase in autism risk with both maternal and paternal age has potential implications for public health planning and investigations of autism etiology...
  39. ncbi Audiovisual speech integration in pervasive developmental disorder: evidence from event-related potentials
    Maurice J C M Magnée
    Rudolf Magnus Institute of Neuroscience, Department of Child and Adolescent Psychiatry, University Medical Center, Utrecht, The Netherlands
    J Child Psychol Psychiatry 49:995-1000. 2008
    ..It has been suggested that communicative impairments among individuals with pervasive developmental disorders (PDD) might be caused by an inability to integrate synchronously presented visual and auditory cues...
  40. ncbi The clinical necessity for assessing Attention Deficit/Hyperactivity Disorder (AD/HD) symptoms in children with high-functioning Pervasive Developmental Disorder (PDD)
    Yuko Yoshida
    Yokohama Psycho Developmental Clinic, 7 7 Chigasaki Chyuo, Tsuzuki ku, Yokohama 224 0032, Japan
    Eur Child Adolesc Psychiatry 13:307-14. 2004
    ..We conclude not only that AD/HD symptoms occur frequently in children with PDD, but also that in some cases a dual diagnosis is essential to the implementation of effective treatment...
  41. ncbi Social skills development in children with autism spectrum disorders: a review of the intervention research
    Susan Williams White
    School of Medicine, Virginia Treatment Center for Children, Virginia Commonwealth University, 515 North 10th Street, Richmond, VA 23298, USA
    J Autism Dev Disord 37:1858-68. 2007
    ..Based on this review, the empirical support for this approach is incomplete, but promising intervention strategies were identified. Recommendations for the design of future treatment trials to guide clinical practice are offered...
  42. ncbi Phenomenology and epidemiology of childhood psychiatric disorders that may necessitate treatment with atypical antipsychotics
    Melissa Delbello
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Clin Psychiatry 65:12-9. 2004
    ..We also describe the differences in the clinical presentation of these disorders between youth and adults...
  43. ncbi Prevalence of pervasive developmental disorders in children and adolescents with mental retardation
    Annelies de Bildt
    Child and Adolescent Psychiatry, University of Groningen, Groningen, The Netherlands
    J Child Psychol Psychiatry 46:275-86. 2005
    ..This variation seems to be related to the concepts of PDD under study, the instruments used, and the studied populations. The present study aimed to estimate a reliable prevalence rate of PDD...
  44. ncbi Systematic screening for subtelomeric anomalies in a clinical sample of autism
    Thomas H Wassink
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    J Autism Dev Disord 37:703-8. 2007
    ..2 in subgroups of our sample. We conclude that while karyotyping may be more broadly indicated for autism than previously supposed, subtelomere FISH appears less likely to be a useful screening tool for unselected PDD populations...
  45. ncbi Multiple complex developmental disorder delineated from PDD-NOS
    Esther I de Bruin
    Department of Child and Adolescent Psychiatry, Erasmus Medical Center Rotterdam Sophia Children s Hospital, Dr Molewaterplein 60, 3015, Rotterdam, and Department of Psychiatry, University Medical Center, Groningen, The Netherlands
    J Autism Dev Disord 37:1181-91. 2007
    ..MCDD was associated with anxiety disorders, disruptive behavior, and psychotic thought problems. PDD-NOS was associated with deficits in social contact. MCDD differs from autistic disorder, and can also be delineated from PDD-NOS...
  46. ncbi A normed study of face recognition in autism and related disorders
    A Klin
    Yale Child Study Center, New Haven Connecticut 06520, USA
    J Autism Dev Disord 29:499-508. 1999
    ..Contrary to our expectation, children with PDDNOS did not show face recognition deficits...
  47. ncbi Perinatal factors and the development of autism: a population study
    Emma J Glasson
    Schools of Population Health and Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Australia
    Arch Gen Psychiatry 61:618-27. 2004
    ..Some investigations have shown an association with obstetric complications but findings have been inconsistent owing to differences in sampling and methods...
  48. ncbi Parental ages at birth of children with pervasive developmental disorders are higher than those of children in the general population
    Tomonori Koyama
    Department of Mental Health Administration, National Institute of Mental Health, National Center for Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Psychiatry Clin Neurosci 61:200-2. 2007
    ..2/33.6 in the national statistics in 2003. This first Japanese study to report elevated parental ages at birth of PDD children underscores the need of further extensive studies...
  49. ncbi PDD symptoms in ADHD, an independent familial trait?
    J S Nijmeijer
    Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    J Abnorm Child Psychol 37:443-53. 2009
    ..The results confirm that children with ADHD have high levels of PDD symptoms, and further suggest that the familiality of subtle PDD symptoms in the context of ADHD is largely independent from ADHD familiality...
  50. ncbi Variability in outcome for children with an ASD diagnosis at age 2
    Lauren M Turner
    University of North Carolina at Chapel Hill, NC 27599 3367, USA
    J Child Psychol Psychiatry 48:793-802. 2007
    ....
  51. ncbi Pervasive developmental disorder and parental adaptation: previewing and reviewing atypical development with parents in child psychiatric consultation
    Peter Schuntermann
    Department of Psychiatry, Harvard Medical School, Children s Hospital, and Beth Israel Deaconess Medical Center, Boston, MA, USA
    Harv Rev Psychiatry 10:16-27. 2002
    ....
  52. ncbi Autistic traits in the general population: a twin study
    John N Constantino
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Gen Psychiatry 60:524-30. 2003
    ....
  53. ncbi The prevalence of autism spectrum disorders. Recent evidence and future challenges
    Tony Charman
    Behavioural and Brain Sciences Unit, Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK
    Eur Child Adolesc Psychiatry 11:249-56. 2002
    ..5/1,000 for autism and 2.0/1,000 for the broader spectrum. Three recent studies have suggested a significantly higher prevalence rate for ASD of 6.0/1,000 (mean 95 % CI = 4.8-8.0)...
  54. ncbi Cognitive and symptom profiles in Asperger's syndrome and high-functioning autism
    Tomonori Koyama
    Department of Mental Health Administration, National Institute of Mental Health, National Center for Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Psychiatry Clin Neurosci 61:99-104. 2007
    ..Autistic cognitive characteristics shared by both AS and HFA subjects appear to support the validity of the current diagnostic classification of PDD...
  55. ncbi Attention-deficit hyperactivity disorder symptoms in a clinic sample of children and adolescents with pervasive developmental disorders
    Douglas O Lee
    Department of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Child Adolesc Psychopharmacol 16:737-46. 2006
    ....
  56. ncbi Autism spectrum disorders: an introduction and review of prevalence data
    Jane M Charles
    Division of Genetics and Developmental Pediatrics, Medical University of South Carolina, 135 Rutledge Avenue, PO Box 250561, Charleston, SC 29425, USA
    J S C Med Assoc 102:267-70. 2006
  57. ncbi Amygdala volume and nonverbal social impairment in adolescent and adult males with autism
    Brendon M Nacewicz
    Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin Madison, Waisman Center, 1500 Highland Avenue, Madison, WI 53705, USA
    Arch Gen Psychiatry 63:1417-28. 2006
    ..Autism is a syndrome of unknown cause, marked by abnormal development of social behavior. Attempts to link pathological features of the amygdala, which plays a key role in emotional processing, to autism have shown little consensus...
  58. ncbi Inhibitory control in children with autism spectrum disorder
    Shawn E Christ
    Department of Psychology, Washington University, St Louis, MO, USA
    J Autism Dev Disord 37:1155-65. 2007
    ..More generally, the findings underscore the importance of using multiple measures to assess a putative single cognitive ability...
  59. ncbi Open-label atomoxetine for attention-deficit/ hyperactivity disorder symptoms associated with high-functioning pervasive developmental disorders
    David J Posey
    Department of Psychiatry and Christian Sarkine Autism Treatment Center at the Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Child Adolesc Psychopharmacol 16:599-610. 2006
    ..The aim of this study was to conduct an initial evaluation of the efficacy of atomoxetine for attention-deficit/hyperactivity disorder (ADHD) symptoms in children with pervasive developmental disorders (PDDs)...
  60. ncbi Educational placements and service use patterns of individuals with autism spectrum disorders
    SUSAN WILLIAMS WHITE
    Virginia Treatment Center for Children, School of Medicine, Virginia Commonwealth University, 515 North 10th Street, Richmond, Virginia 23298, USA
    J Autism Dev Disord 37:1403-12. 2007
    ..Findings highlight the emphasis placed on certain child characteristics (e.g., cognitive ability), with far less emphasis on other areas (e.g., degree of social deficit), in educational placement and service provision...
  61. ncbi Atypical lexical/semantic processing in high-functioning autism spectrum disorders without early language delay
    Yoko Kamio
    Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, 187 8553, Tokyo, Japan
    J Autism Dev Disord 37:1116-22. 2007
    ..This finding suggests similarities in the underlying semantic processing of language across PDD subtypes...
  62. ncbi Structure of the autism symptom phenotype: A proposed multidimensional model
    Stelios Georgiades
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Am Acad Child Adolesc Psychiatry 46:188-96. 2007
    ....
  63. ncbi Evaluation of a methodology for a collaborative multiple source surveillance network for autism spectrum disorders--Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2002
    Kim Van Naarden Braun
    National Center on Birth Defects and Developmental Disabilities, CDC, USA
    MMWR Surveill Summ 56:29-40. 2007
    ....
  64. ncbi Pharmacological treatment options for autism spectrum disorders in children and adolescents
    Thomas J Leskovec
    Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Harv Rev Psychiatry 16:97-112. 2008
    ..This article reviews what is known about the efficacy and tolerability of pharmacological interventions for the treatment of children and adolescents suffering from autistic spectrum disorders...
  65. ncbi Reliability and validity of the Pervasive Developmental Disorders Assessment System
    Hiroshi Kurita
    Zenkoku Ryoiku Sodan Center, Tokyo, Japan
    Psychiatry Clin Neurosci 62:226-33. 2008
    ..To test the reliability and validity of the Pervasive Developmental Disorders Assessment System (PDDAS), a Japanese semistructured interview system...
  66. ncbi Matching-to-sample assessment of stimulus overselectivity in students with intellectual disabilities
    Chata A Dickson
    University of Massachusetts Medical School, Shriver Center, Waltham, MA 02452, USA
    Am J Ment Retard 111:447-53. 2006
    ..28 years). Performances of students with overselectivity were more variable than those with no overselectivity. The MAE scores were related to both matching-to-sample performance and stimulus overselectivity...
  67. ncbi Epidemiological findings of pervasive developmental disorders in a Venezuelan study
    Cecilia Montiel-Nava
    La Universidad del Zulia, Maracaibo, Venezuela
    Autism 12:191-202. 2008
    ..An ASD prevalence of 1.7 per 1000 should alert the health and education authorities to the need to reassess the services available for children with these disorders and their families...
  68. ncbi Autism and coeliac disease
    Giulia Barcia
    J Autism Dev Disord 38:407-8. 2008
  69. pmc Psychiatric hospitalization among children with autism spectrum disorders
    David S Mandell
    Center for Mental Health Policy and Services Research, University of Pennsylvania School of Medicine, 3535 Market Street, 3rd Floor, Philadelphia, PA 19104, USA
    J Autism Dev Disord 38:1059-65. 2008
    ..Risk for hospitalization increased with age and over time. The results suggest early diagnosis and community-based interventions for aggressive and self-injurious behaviors may reduce hospitalizations...
  70. ncbi Emotional distress and its correlates among parents of children with pervasive developmental disorders
    Atsurou Yamada
    Department of Psychiatry and Cognitive Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Psychiatry Clin Neurosci 61:651-7. 2007
    ..Clinicians can deliver better service by paying appropriate attention to the emotional distress of mothers of children with not only autistic disorder but also other PDD...
  71. ncbi Parent-rated anxiety symptoms in children with pervasive developmental disorders: frequency and association with core autism symptoms and cognitive functioning
    Denis G Sukhodolsky
    The Child Study Center, Yale University, 230 South Frontage Road, New Haven, CT 06520, USA
    J Abnorm Child Psychol 36:117-28. 2008
    ..Limited data are available on the prevalence of anxiety in these children. We examined frequency and correlates of parent-rated anxiety symptoms in a large sample of children with PDD...
  72. ncbi Pervasive developmental disorders and criminal behaviour: a case control study
    Svend Erik Mouridsen
    Bispebjerg University Hospital, Copenhagen, Denmark
    Int J Offender Ther Comp Criminol 52:196-205. 2008
    ..1% and 18.4%, respectively. The corresponding rate of convictions in the comparison groups was 18.9%, 14.7%, and 19.6% respectively. Particular attention is given to arson in Asperger's syndrome (p= .0009)...
  73. ncbi Recurrence risk in Autism Spectrum Disorder: a study of parental knowledge
    Charlotte Whitelaw
    Calvary Health Care Tasmania, Hobart, Tasmania, Australia
    J Paediatr Child Health 43:752-4. 2007
    ..To describe recurrence risk information currently being obtained by families affected by Autism Spectrum Disorder (ASD)...
  74. ncbi Estimating the burden of disease for autism spectrum disorders in Spain in 2003
    Elena Sánchez-Valle
    Rare Diseases Research Institute, Instituto de Salud Carlos III, Sinesio Delgado, 6, Madrid 28029, Spain
    J Autism Dev Disord 38:288-96. 2008
    ..DALY could be a useful tool for health policy makers for setting health service priorities, allocating available resources effectively and providing a comparable measure of output for early intervention...
  75. pmc Impairment of quality of life in parents of children and adolescents with pervasive developmental disorder
    Diego Mugno
    Division of Child Neurology and Psychiatry, Department of Pediatrics, University of Catania, Catania, Italy
    Health Qual Life Outcomes 5:22. 2007
    ....
  76. ncbi Autism and cytogenetic abnormalities: solving autism one chromosome at a time
    Christa Lese Martin
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Curr Psychiatry Rep 9:141-7. 2007
    ..Powerful new methods for identifying novel regions of the genome causing or contributing to autism also will be discussed and will start to explain the etiology for some percentage of the remaining 85% to 90% of autism cases...
  77. ncbi [Autism in childhood]
    Akira Nakane
    Seishin Shinkeigaku Zasshi 108:1119-27. 2006
  78. ncbi Access to care for autism-related services
    Kathleen C Thomas
    Cecil G Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, 725 Martin Luther King Jr Blvd CB 7590, Chapel Hill, NC 27599 7590, USA
    J Autism Dev Disord 37:1902-12. 2007
    ..Disparities in service use associated with race, residence and education point to the need to develop policy, practice and family-level interventions that can address barriers to services for children with ASD...
  79. ncbi Autism, Asperger's and other oddities ... thoughts about treatment approaches
    Clarice J Kestenbaum
    Division of Child and Adolescent Psychiatry, Department of Psychiatry, The New York State Psychiatric Institute, 1051 Riverside Drive, Box 74, New York, NY 10032, USA
    J Am Acad Psychoanal Dyn Psychiatry 36:279-94. 2008
    ..Clinical case material is used to illustrate how the treatment modality utilized should be fitted to an individual child's needs. A multimodal treatment plan is considered optimal in order to achieve a successful therapeutic outcome...
  80. ncbi Relationship between clinical and genetic features in "inverted duplicated chromosome 15" patients
    R Borgatti
    Department of Child Neurorehabilitation, Scientific Institute Eugenio Medea, Bosisio Parini (Lecco, Italy
    Pediatr Neurol 24:111-6. 2001
    ..Nevertheless, the influence of gene content of the marker chromosome, particularly the three gamma-aminobutyric acid-A receptor subunit genes, may represent the link between epilepsy, mental retardation, and PDD...
  81. ncbi Modeling clinical outcome of children with autistic spectrum disorders
    James Coplan
    University of Pennsylvania School of Medicine, Philadelphia, USA
    Pediatrics 116:117-22. 2005
    ....
  82. ncbi Incidence of autism spectrum disorders in children in two Australian states
    Katrina Williams
    Children s Hospital at Westmead, Sydney, NSW
    Med J Aust 182:108-11. 2005
    ..To ascertain the incidence of autism spectrum disorders in Australian children...
  83. ncbi The incidence and prevalence of pervasive developmental disorders: a Danish population-based study
    M B Lauritsen
    Department of Psychiatric Demography, Psychiatric Hospital in Aarhus, Denmark
    Psychol Med 34:1339-46. 2004
    ..Based on prevalence studies and the few incidence studies of pervasive developmental disorders (PDDs) the prevalence and incidence of these disorders have been claimed to be increasing...
  84. ncbi MMR vaccination and pervasive developmental disorders: a case-control study
    Liam Smeeth
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Lancet 364:963-9. 2004
    ..We investigated whether MMR vaccination is associated with an increased risk of autism or other pervasive developmental disorders...
  85. ncbi Are patients with social developmental disorders prosopagnosic? Perceptual heterogeneity in the Asperger and socio-emotional processing disorders
    Jason J S Barton
    Department of Neurology, KS 452, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston MA 02215, USA
    Brain 127:1706-16. 2004
    ..Heterogeneity in the perceptual processing of faces may imply pathogenetic heterogeneity, with important implications for genetic and rehabilitative studies of SDD...
  86. ncbi [Sixty years of autism]
    I A van Berckelaer-Onnes
    Universiteit Leiden, Faculteit der Sociale Wetenschappen, Ambulatorium, Postbus 9555, 2300 RB Leiden
    Ned Tijdschr Geneeskd 148:1024-30. 2004
    ..Augmentative communication plays a key role in the treatment. People with autism need a lot of structure, clarity and predictability, also when they have become adults...
  87. ncbi Comparison of high-functioning atypical autism and childhood autism by Childhood Autism Rating Scale-Tokyo version
    Chieko Kanai
    Department of Mental Health, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Psychiatry Clin Neurosci 58:217-21. 2004
    ..Affect tended to be significantly milder in HAA than HCA. Anxiety reaction was significantly more abnormal in HAA than HCA. These findings may be useful to distinguish between HAA and HCA...
  88. ncbi [Diagnostic Observation Scale for Autistic Disorders: initial results of reliability and validity]
    S Bolte
    Klinik für Psychiatrie und Psychotherapie des Kindes und Jugendalters des Klinikums der Johann Wolfgang Goethe Universität Frankfurt am Mair
    Z Kinder Jugendpsychiatr Psychother 32:45-50. 2004
    ..To examine the psychometric properties of the German version of the Autism Diagnostic Observation Schedule (ADOS)...
  89. ncbi Developmental, behavioural and somatic factors in pervasive developmental disorders: preliminary analysis
    P Whiteley
    Autism Research Unit, University of Sunderland, Sunderland, UK
    Child Care Health Dev 30:5-11. 2004
    ....
  90. ncbi Autism families with a high incidence of alcoholism
    Judith H Miles
    Division of Medical Genetics, University of Missouri Hospitals and Clinics, 1 Hospital Drive, Columbia, MO 65212, USA
    J Autism Dev Disord 33:403-15. 2003
    ..Children from high alcoholism families were less likely to be macrocephalic (14.7% vs. 40.6%, p = 0.0006). Children from high alcohol and low alcohol families did not differ in dysmorphology status, IQ, sex ratio or sib recurrence risk...
  91. ncbi Use of citalopram in pervasive developmental disorders
    Lisa B Namerow
    Department of Psychiatry, Hartford Hospital, University of Connecticut School of Medicine, Hartford, Connecticut 06106, USA
    J Dev Behav Pediatr 24:104-8. 2003
    ..78, p =.005). Mild side effects were reported by five patients (33%). These data suggest citalopram may be effective, safe, and well tolerated as part of the treatment of PDDs...
  92. ncbi Childhood autism rating scale--Tokyo version for screening pervasive developmental disorders
    Hisateru Tachimori
    Department of Mental Health Administration, National Institute of Mental Health, National Center for Neurology and Psychiatry, Chiba, Japan
    Psychiatry Clin Neurosci 57:113-8. 2003
    ..71, 0.75, 0.77 and 0.69, respectively. CARS-TV seems to be a useful instrument for differentiating between PDD and non-PDD MR and between AD and PDDNOS, although further replication is needed...
  93. ncbi Molecular and cytogenetic analyses on Brazilian youths with pervasive developmental disorders
    MarcosRobertoHigino Estécio
    Laboratório de Citogenética e Biologia Molecular, Instituto de Bio ciências, Letras e Ciências Exatas UNESP Campus de São José do Rio Preto, SP, Brazil
    J Autism Dev Disord 32:35-41. 2002
    ....
  94. ncbi Autism and epilepsy: cause, consequence, comorbidity, or coincidence?
    Lidia Gabis
    Child Development Center, Safra Children s Hospital, Tel Hashomer, Israel
    Epilepsy Behav 7:652-6. 2005
    ....
  95. ncbi The scope of occupational therapy services for individuals with autism spectrum disorders across the lifespan
    Renee Watling
    Am J Occup Ther 59:680-3. 2005
  96. ncbi Residual language deficits in optimal outcome children with a history of autism
    Elizabeth Kelley
    Department of Psychology, University of Connecticut, 406 Babbidge Road, Unit 1020, Storrs, CT 06269 1020, USA
    J Autism Dev Disord 36:807-28. 2006
    ..Results indicated that while these children's grammatical capabilities are mostly indistinguishable from their peers, they are still experiencing difficulties in pragmatic and semantic language...
  97. ncbi Neonatal hyperbilirubinemia and risk of autism spectrum disorders
    Lisa A Croen
    Kaiser Permanente, Division of Research, 2000 Broadway, Oakland, CA 94612, USA
    Pediatrics 115:e135-8. 2005
    ..To investigate the association between neonatal hyperbilirubinemia and autism spectrum disorders (ASD)...
  98. ncbi A naturalistic retrospective analysis of psychostimulants in pervasive developmental disorders
    Kimberly A Stigler
    Department of Psychiatry, Indiana University School of Medicine, James Whitcomb Riley Hospital for Children, Indianapolis, Indiana, USA
    J Child Adolesc Psychopharmacol 14:49-56. 2004
    ..We set out to examine the effectiveness and tolerability of psychostimulants in children and adolescents with pervasive developmental disorders (PDDs)...
  99. ncbi Attachment in toddlers with autism and other developmental disorders
    Fabienne B A Naber
    Department of Education and Child Studies, Centre for Child and Family Studies, University of Leiden, P O Box 9555, 2300 RB, Leiden, The Netherlands
    J Autism Dev Disord 37:1123-38. 2007
    ..Controlling for basal cortisol and developmental level, more autistic symptoms predicted lower cortisol responses to the SSP. The findings support the importance of disorganized attachment for children with autism...
  100. ncbi Autism: a medical primer
    Christopher D Prater
    Department of Family Medicine, University of Tennessee College of Medicine, Chattanooga 37403, USA
    Am Fam Physician 66:1667-74. 2002
    ..Many different treatment approaches can be used, some of which are unproven and have little scientific support. Parents may be encouraged to investigate national resources and local support networks...
  101. ncbi Autism spectrum disorders and epilepsy: moving towards a comprehensive approach to treatment
    Roberto Tuchman
    Department of Neurology, Miami Children s Hospital, Dan Marino Center, Weston, FL, USA
    Brain Dev 32:719-30. 2010
    ..The best hope for good developmental outcomes in children with ASD and epilepsy is early recognition and comprehensive treatment of both the ASD and epilepsy...

Research Grants67

  1. METHYLPHENIDATE TREATMENT OF ADHD IN CHILDREN WITH TS
    Kenneth Gadow; Fiscal Year: 2004
    ..To evaluate the impact of tic severity and comorbid internalizing and externalizing symptoms on clinical outcome, children with ADHD/+tics will be compared with an additional sample of children with ADHD/-tics at ages 11 and 16 years. ..
  2. Psychopharmacology of Autism and related Disorders
    David Posey; Fiscal Year: 2007
    ..Towards the later years of the award, the candidate will have performed additional studies and applied for independent research funding. ..
  3. Anger Control Training for Youth with Tourette Syndrome
    Larry Scahill; Fiscal Year: 2005
    ..This design will permit demonstration of a clinically relevant effect size for anger control training in adolescents with TS. ..
  4. RUPP-PI Program at Yale University
    Lawrence Scahill; Fiscal Year: 2006
    ..Furthermore, this five-site network has established reliability on several measures that are relevant to the conduct of clinical trials in children with PDD. ..
  5. Behavior Therapy for Adults with Tourette Syndrome
    Lawrence Scahill; Fiscal Year: 2009
    ..The Informatics group at Yale University will provide data management services. ..
  6. A QUANTITATIVE GENETIC MEASURE OF AUTISTIC TRAITS
    John Constantino; Fiscal Year: 2002
    ..If the SRS compares favorably with the ADI-R, the SRS could feasibly be used to study the genetics of autism by examining the genetic structure of autistic traits in whole populations. ..
  7. RUPP-PI
    Christopher McDougle; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] ..
  8. Prenatal Exposure to Polyfluoroalkyl Compounds in the EMA Study
    Lisa A Croen; Fiscal Year: 2010
    ..In the long-term, a better understanding of the underlying biology may suggest appropriate strategies for early intervention and contribute to the eventual prevention of this often devastating and usually life-long disability. ..
  9. UW Autism Research Center of Excellence
    Elizabeth Aylward; Fiscal Year: 2007
    ..5) To conduct molecular biology studies aimed at gene discovery in autism. Identification of susceptibility genes in autism is important for early identification, prevention, and medical treatment (Project V). ..
  10. NEUROBIOLOGY AND GENETICS OF AUTISM
    Geraldine Dawson; Fiscal Year: 2006
    ..Thus, findings from all five research projects are being integrated in a synergistic way to offer a deeper understanding of the neurobiological and genetic basis of autism. ..
  11. Divalproex Sodium/Placebo In Child/Adolesent Autism
    Eric Hollander; Fiscal Year: 2003
    ....
  12. Greater New York Autism Research Center of Excellence
    Joseph Buxbaum; Fiscal Year: 2007
    ..Core B: Clinical Core; Core C: Data Management and Statistics Core; Core D: Information Transfer Core. ..
  13. Genetic Bases of Developmental Language Disorders
    Elena L Grigorenko; Fiscal Year: 2010
    ..abstract_text> ..
  14. PHARMACOTHERAPY OF ADOLESCENT BODY DYSMORPHIC DISORDER
    Eric Hollander; Fiscal Year: 2002
    ..When untreated, adolescent-onset BDD appears to often interfere with the developmental tasks of adolescence, to persist, and to cause substantial morbidity through out the life span. ..
  15. A Randomized Trial of the STAR Program for Children with Autism Spectrum Disorder
    David Mandell; Fiscal Year: 2009
    ..Findings from the proposed study would provide timely and critical evidence regarding the implementation and effectiveness of one promising practice, with direct relevance to translation of findings into practice and policy. ..
  16. Prenatal and Neonatal Biologic Markers for Autism
    Lisa Croen; Fiscal Year: 2006
    ..abstract_text> ..
  17. Training in Psychopharmacology and Outcomes Research
    Eric Hollander; Fiscal Year: 2008
    ..of Medicine of Medicine of Medicine of Medicine of Medicine of Medicine format shown below. Role on ..
  18. TREATMENT OF EARLY ONSET SCHIZOPHRENIA SPECTRUM (TEOSS)
    Robert Findling; Fiscal Year: 2005
    ..This study will provide information about the comparative effectiveness of the most commonly used and representative antipsychotic drugs in youth with schizophrenia spectrum disorders. ..
  19. Novel Pharmacological Strategies in Autism
    Christopher McDougle; Fiscal Year: 2009
    ..Phase II (following 6 months of aripiprazole monotherapy). ..
  20. FLUOXETINE IN PEDIATRIC BODY DYSMORPHIC DISORDER
    Eric Hollander; Fiscal Year: 2008
    ..Abstract Not Provided. ..
  21. Epidemiology of SBCAD Deficiency in Hmong-Americans
    Maureen Durkin; Fiscal Year: 2009
    ..The findings may also prompt future studies of the efficacy of early treatment and dietary restriction to prevent developmental disabilities in children with SBCADD. ..
  22. Adolescent Siblings of Brothers or Sisters with Autism
    Gael Orsmond; Fiscal Year: 2004
    ..An overall goal of the study in this proposal is to establish a sample of siblings who, with additional funding in the future, could be followed longitudinally as they transition to adulthood. ..
  23. VALPROATE RESPONSE IN AGGRESSIVE AUTISTIC ADOLESCENTS
    Jessica Hellings; Fiscal Year: 2002
    ..Study results will be prepared and submitted as manuscripts for publications and presentations. Achievement of goals of the grant will be monitored by Dr. Schroeder weekly, quarterly and annually. ..
  24. APOE Genotype and Sequelae of Infant Cardiac Surgery
    James Gaynor; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  25. Investigation of MeCP2 Function in Rett Syndrome
    N Carolyn Schanen; Fiscal Year: 2010
    ..The long term goals are to understand the pathogenesis of the dysfunction of the nervous system in patients with RTT and determine ways that the system can be modulated to potentially improve function and develop targeted therapies. ..
  26. Sensory Gating Mediated by Attention
    Patricia Davies; Fiscal Year: 2007
    ..Improved measures of sensory gating may lead to productive and cost efficient studies assessing treatment effectiveness. [unreadable] [unreadable] [unreadable]..
  27. Genetic Determinants of Brain Structure and Disease Risk in Schizophrenia
    Thomas H Wassink; Fiscal Year: 2010
    ....
  28. GABA (A) Receptors in Developmental Epileptogenesis
    Amy Brooks Kayal; Fiscal Year: 2009
    ....
  29. Posttraumatic Stress Disorder in Preschool Children
    Michael Scheeringa; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  30. Adolescent Outcomes of <1000 gram Birth Weight Children
    Maureen Hack; Fiscal Year: 2010
    ..Our data will also provide important information needed for the planning and provision of services for ELBW children who survive neonatal intensive care. ..
  31. Effects of Intensity of Early Communication Intervention
    STEVEN WARREN; Fiscal Year: 2009
    ..Analyses will include t-tests, 2x2 ANOVA, and multi-level analysis (HLM). Multiple regression or ANCOVA will be used if statistical control of pre-treatment differences are necessary. Five years of funding is requested. ..
  32. Fathers as in-home trainers of autistic children
    Jennifer Elder; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  33. AUTISM--BRAIN MORPHOMETRY AND COGNITIVE NEUROSCIENCE
    Martha Herbert; Fiscal Year: 2003
    ..The nature of developmental dysregulation and neural systems abnormalities in this disorder should thus become clearer. ..
  34. Language Functioning in Optimal Outcome Children with a History of Autism
    Deborah Fein; Fiscal Year: 2009
    ....
  35. Topiramate for Co-occurring Cannabis Use and Bipolar Disorders in Adolescents
    Melissa Delbello; Fiscal Year: 2008
    ..The preliminary data from this projectwill inform and guide the design of future larger, more definitive, controlled studies of topiramate as a treatment for adolescent substance use disorders. ..
  36. Multimodal Neuroimaging of White Matter in Autism
    Martha Herbert; Fiscal Year: 2009
    ..Our study design will also detect alternate outcomes and will yield data relevant for multiple levels of translational research. ..
  37. The Social Neuroscience of Autism and Related Disorders
    Fred Volkmar; Fiscal Year: 2007
    ....
  38. IDENTIFICATION OF GENES INFLUENCING DYSLEXIA
    Shelley Smith; Fiscal Year: 2001
    ..Linkage and association analysis will be used to verify that a candidate gene effects reading disability in the 175 nuclear families. ..
  39. Predictors of Skin Cancer in Commercial Airline Pilots
    Joyce Nicholas; Fiscal Year: 2005
    ..abstract_text> ..
  40. BRAIN METABOLISM AND TREATMENT OUTCOME IN PANIC DISORDER
    Stephen Dager; Fiscal Year: 2004
    ..abstract_text> ..
  41. A MULTI-FACETED SEARCH FOR AUTISM DISEASE GENES
    Thomas Wassink; Fiscal Year: 2004
    ..Taken together, the training plan and research proposal provide for a breadth of training, the potential for meaningful discovery, and support for the establishment of an independent research career. ..
  42. Lymphocytic Targets and Behavior in Fragile X
    Walter Kaufmann; Fiscal Year: 2004
    ..Because of their innovative approach to examining genotype-phenotype relationships, we believe that the proposed studies are in accordance with the purposes of the Exploratory/Developmental Grant (R21) Program. ..
  43. Therapeutic Placebos as Complementary Therapy in ADHD
    Adrian Sandler; Fiscal Year: 2004
    ....
  44. A Joint Attention Intervention with Caregivers and thei*
    Connie Kasari; Fiscal Year: 2003
    ..The exploratory and pilot research will lay the necessary groundwork leading up to a full-scale randomized and comparative study of the treatment. ..
  45. Medication Management Decisions in Schizophrenia
    Mark Olfson; Fiscal Year: 2003
    ..The results will inform quality improvement programs by identifying key modifiable determinants of the quality of medication management in the community treatment of schizophrenia. ..
  46. TRAUMATIZED YOUNG CHILDREN--RISK FOR MALADAPTATION
    Michael Scheeringa; Fiscal Year: 2002
    ..One- and 2-year follow-up assessments will be conducted. ..
  47. Children with Chronic Health Conditions: Family Impact
    KAREN KUHLTAHU; Fiscal Year: 2002
    ....
  48. GENETIC REGULATION OF TELENCEPHALON DEVELOPMENT
    John Rubenstein; Fiscal Year: 2002
    ....
  49. AUTISM--A MODEL OF ANOMALOUS NEURAL SYSTEMS DEVELOPMENT
    Pauline Filipek; Fiscal Year: 2001
    ....
  50. Problems and Competence under Age5: School Transition
    Alice Carter; Fiscal Year: 2005
    ....
  51. Reliability of Cognitive ERPs in Children and Adults
    Patricia Davies; Fiscal Year: 2006
    ..This information will be helpful, especially when clinical populations (e.g., attention deficit disorders and learning disabilities) are included in developmental ERP studies. [unreadable] [unreadable]..
  52. Neurobiology and genetics of Autism & Related Conditions
    Fred Volkmar; Fiscal Year: 2006
    ..This program project builds on the network of existing collaborations and makes use of important resources at each site. ..
  53. Adolescent Social Phobia and Neurophysiological Function
    Christopher Monk; Fiscal Year: 2006
    ..The long-term goal is to identify neurobiological and behavioral events that underlie the development of childhood anxiety disorders. ..
  54. A Pharmacogenetic Study of Escitalopram in Autism
    Thomas Owley; Fiscal Year: 2006
    ..abstract_text> ..
  55. Examining Contingency Control Deficits in Autism and MR
    Louis Hagopian; Fiscal Year: 2006
    ..The proposed investigation can be used to set up future comparative research to contrast EF and operant approaches to the performance deficits displayed by individuals with autism. ..
  56. Eye-Tracking Studies of Social Visual Pursuit in Autism
    Ami Klin; Fiscal Year: 2006
    ..The proposed R01 works synergistically with other ongoing eye-tracking research including studies of toddlers at risk of having autism and studies of monkeys with mesiofrontal-limbic ablations. ..
  57. NKX HOMEOBOX GENE REGULATION OF VENTRAL CNS DEVELOPMENT
    John Rubenstein; Fiscal Year: 2003
    ..A collaborator, Dr. Puelles, will visit the lab twice, for two months each, to help analyze the expression patterns and morphological mutant phenotypes. ..
  58. Oral Health Disparities in Publicly Insured Children
    TEGWYN BRICKHOUSE; Fiscal Year: 2008
    ..Benefit: This mix of quantitative techniques and a clinical study will be utilized to address the NIDCR Priority Research Area of eliminating oral health disparities. [unreadable] [unreadable]..
  59. Reward System Recovery Following Behavioral Activation Therapy in Depression
    GABRIEL DICHTER; Fiscal Year: 2007
    ..Such a strategy is consistent with NIMH's mission to reduce the burden of psychiatric disorders. [unreadable] [unreadable] [unreadable]..
  60. GENETIC REGULATION OF TELENCEPHALON DEVELOPMENT
    John Rubenstein; Fiscal Year: 2007
    ..abstract_text> ..
  61. Cognitive Genetic Aspects of Duchenne Muscular Dystrophy
    Veronica Hinton; Fiscal Year: 2006
    ..And newly characterized preschool boys with DMD will be followed to track their language and emotional development. [unreadable] [unreadable]..
  62. New DHFR Deletion Polymorphism - A Risk Factor for SB?
    William Johnson; Fiscal Year: 2003
    ..Forms of foliate that are already reduced could be preferable as foliate supplements during pregnancy for prevention of SB. ..
  63. ADHD Symptoms in Autism: Cognition, Behavior, Treatment
    Deborah Pearson; Fiscal Year: 2009
    ..Thus, the primary goals of the proposed research are to characterize ADHD in school-aged children with Autistic Disorder (DSM-IV), and to assess their cognitive and behavioral response to MPH. ..
  64. Long-Term Olanzapine Treatment in children with Autism
    Richard Malone; Fiscal Year: 2008
    ..Phase 2 is a long-term (6 months) maintenance study of olanzapine responders who continue on open-labeled treatment. Phase 3 is a naturalistic follow-up of subjects. Multiple measures and raters are employed. ..
  65. Evaluation of Diagostic and Services Practices in Autism
    Natacha Akshoomoff; Fiscal Year: 2008
    ..abstract_text> ..
  66. Controlled Study of Olanzapine in Children with Autism
    Richard Malone; Fiscal Year: 2005
    ..Abstract Not Provided ..
  67. PEDIATRIC BIPOLAR COLLABORATIVE MOOD STABILZER TRAIL
    Robert Findling; Fiscal Year: 2003
    ..Lastly, this trial will provide descriptive information on the stability of acute phase response to monotherapy over a 16 week continuation phase. ..