dyslexia

Summary

Summary: A cognitive disorder characterized by an impaired ability to comprehend written and printed words or phrases despite intact vision. This condition may be developmental or acquired. Developmental dyslexia is marked by reading achievement that falls substantially below that expected given the individual's chronological age, measured intelligence, and age-appropriate education. The disturbance in reading significantly interferes with academic achievement or with activities of daily living that require reading skills. (From DSM-IV)

Top Publications

  1. ncbi Working memory in children with reading disabilities
    Susan Elizabeth Gathercole
    Department of Psychology, University of Durham, Science Laboratories, Durham DH1 3LE, UK
    J Exp Child Psychol 93:265-81. 2006
  2. ncbi The relationship among receptive and expressive vocabulary, listening comprehension, pre-reading skills, word identification skills, and reading comprehension by children with reading disabilities
    Justin C Wise
    Georgia State University, 1400 Decatur Street, SE, Suite 1151, Atlanta, GA 30303, USA
    J Speech Lang Hear Res 50:1093-109. 2007
  3. pmc Neural deficits in children with dyslexia ameliorated by behavioral remediation: evidence from functional MRI
    Elise Temple
    Program in Neuroscience, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 100:2860-5. 2003
  4. ncbi Dyslexics are impaired on implicit higher-order sequence learning, but not on implicit spatial context learning
    James H Howard
    Department of Psychology, The Catholic University of America, Washington, DC 20064, USA
    Neuropsychologia 44:1131-44. 2006
  5. pmc Extra-large letter spacing improves reading in dyslexia
    Marco Zorzi
    Department of General Psychology and Center for Cognitive Science, University of Padova, 35131 Padua, Italy
    Proc Natl Acad Sci U S A 109:11455-9. 2012
  6. ncbi Music, rhythm, rise time perception and developmental dyslexia: perception of musical meter predicts reading and phonology
    Martina Huss
    Centre for Neuroscience in Education, University of Cambridge, UK
    Cortex 47:674-89. 2011
  7. pmc Functional connectivity of the angular gyrus in normal reading and dyslexia
    B Horwitz
    Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:8939-44. 1998
  8. ncbi Developmental dyslexia: the visual attention span deficit hypothesis
    Marie Line Bosse
    Laboratoire de Psychologie et Neuro Cognition UMR 5105 CNRS, Université Pierre Mendès France, 1251 Ave Centrale BP 47, 38040 Grenoble Cedex 9, France
    Cognition 104:198-230. 2007
  9. ncbi Association of abnormal cerebellar activation with motor learning difficulties in dyslexic adults
    R I Nicolson
    Department of Psychology, University of Sheffield, UK
    Lancet 353:1662-7. 1999
  10. ncbi Improving early language and literacy skills: differential effects of an oral language versus a phonology with reading intervention
    Claudine Bowyer-Crane
    Department of Psychology, University of York, Heslington, York, UK
    J Child Psychol Psychiatry 49:422-32. 2008

Research Grants

  1. Molecular Diagnosis of Dyslexia
    Seiyu Hosono; Fiscal Year: 2007
  2. NIRS Optical Topography System - Hitachi ETG-4000
    Allan Reiss; Fiscal Year: 2007
  3. Feature selectivity of auditory thalamus
    Edward Bartlett; Fiscal Year: 2005
  4. EEG Synchrony, perinatal risk and outcome: analysis of CHIME data
    PHILIP GEORGE GRIEVE; Fiscal Year: 2010
  5. MRDD Research Center
    KARL PFENNINGER; Fiscal Year: 2009
  6. DETERMINATION OF NEURONAL FATES IN VISUAL CORTEX
    Susan K McConnell; Fiscal Year: 2013
  7. Foxp2 regulation of sex specific transcriptional pathways and brain development
    JERALD MICHAEL BOWERS; Fiscal Year: 2013
  8. Estradiol, GABA and Developing Hippocampal Cells
    JERALD MICHAEL BOWERS; Fiscal Year: 2011
  9. Investigating readout of cerebellar synchrony in delay eyeblink conditioning
    ALEXANDER D KLOTH; Fiscal Year: 2013
  10. A MICRO-ELECTRODE STUDY OF OXYGEN-BASED FUNCTIONAL CONNECTIVITY
    Lawrence H Snyder; Fiscal Year: 2012

Detail Information

Publications330 found, 100 shown here

  1. ncbi Working memory in children with reading disabilities
    Susan Elizabeth Gathercole
    Department of Psychology, University of Durham, Science Laboratories, Durham DH1 3LE, UK
    J Exp Child Psychol 93:265-81. 2006
    ..Possible mechanisms for the contribution of working memory to learning, and the implications for educational practice, are considered...
  2. ncbi The relationship among receptive and expressive vocabulary, listening comprehension, pre-reading skills, word identification skills, and reading comprehension by children with reading disabilities
    Justin C Wise
    Georgia State University, 1400 Decatur Street, SE, Suite 1151, Atlanta, GA 30303, USA
    J Speech Lang Hear Res 50:1093-109. 2007
    ..The purpose of this study was to examine proposed causal relationships among different linguistic subsystems and different measures of reading achievement in a group of children with reading disabilities...
  3. pmc Neural deficits in children with dyslexia ameliorated by behavioral remediation: evidence from functional MRI
    Elise Temple
    Program in Neuroscience, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 100:2860-5. 2003
    Developmental dyslexia, characterized by unexplained difficulty in reading, is associated with behavioral deficits in phonological processing...
  4. ncbi Dyslexics are impaired on implicit higher-order sequence learning, but not on implicit spatial context learning
    James H Howard
    Department of Psychology, The Catholic University of America, Washington, DC 20064, USA
    Neuropsychologia 44:1131-44. 2006
    Developmental dyslexia is characterized by poor reading ability and impairments on a range of tasks including phonological processing and processing of sensory information...
  5. pmc Extra-large letter spacing improves reading in dyslexia
    Marco Zorzi
    Department of General Psychology and Center for Cognitive Science, University of Padova, 35131 Padua, Italy
    Proc Natl Acad Sci U S A 109:11455-9. 2012
    Although the causes of dyslexia are still debated, all researchers agree that the main challenge is to find ways that allow a child with dyslexia to read more words in less time, because reading more is undisputedly the most efficient ..
  6. ncbi Music, rhythm, rise time perception and developmental dyslexia: perception of musical meter predicts reading and phonology
    Martina Huss
    Centre for Neuroscience in Education, University of Cambridge, UK
    Cortex 47:674-89. 2011
    ..of language, via speech prosody, and there is evidence for rhythmic perceptual difficulties in developmental dyslexia. Here we investigate the hypothesis that the accurate perception of musical metrical structure is related to ..
  7. pmc Functional connectivity of the angular gyrus in normal reading and dyslexia
    B Horwitz
    Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:8939-44. 1998
    ..the left angular gyrus is functionally disconnected from these regions in men with persistent developmental dyslexia, suggesting that the anatomical disconnection of the left angular gyrus from other brain regions that are part of ..
  8. ncbi Developmental dyslexia: the visual attention span deficit hypothesis
    Marie Line Bosse
    Laboratoire de Psychologie et Neuro Cognition UMR 5105 CNRS, Université Pierre Mendès France, 1251 Ave Centrale BP 47, 38040 Grenoble Cedex 9, France
    Cognition 104:198-230. 2007
    ..recent empirical data and theoretical accounts suggest that a VA span deficit might contribute to developmental dyslexia, independently of a phonological disorder...
  9. ncbi Association of abnormal cerebellar activation with motor learning difficulties in dyslexic adults
    R I Nicolson
    Department of Psychology, University of Sheffield, UK
    Lancet 353:1662-7. 1999
    ..We wanted to find out whether there was abnormal brain activation when dyslexic adults undertook tasks known normally to involve cerebellar activation...
  10. ncbi Improving early language and literacy skills: differential effects of an oral language versus a phonology with reading intervention
    Claudine Bowyer-Crane
    Department of Psychology, University of York, Heslington, York, UK
    J Child Psychol Psychiatry 49:422-32. 2008
    ..This study compares the efficacy of two school-based intervention programmes (Phonology with Reading (P + R) and Oral Language (OL)) for children with poor oral language at school entry...
  11. ncbi A temporal sampling framework for developmental dyslexia
    Usha Goswami
    Centre for Neuroscience in Education, University of Cambridge, Downing St, Cambridge, UK, CB2 3EB
    Trends Cogn Sci 15:3-10. 2011
    Neural coding by brain oscillations is a major focus in neuroscience, with important implications for dyslexia research...
  12. ncbi Understanding normal and impaired word reading: computational principles in quasi-regular domains
    D C Plaut
    Department of Psychology, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213 3890, USA
    Psychol Rev 103:56-115. 1996
    ..Further analyses of the ability of networks to reproduce data on acquired surface dyslexia support a view of the reading system that incorporates a graded division of labor between semantic and ..
  13. ncbi Reading acquisition, developmental dyslexia, and skilled reading across languages: a psycholinguistic grain size theory
    Johannes C Ziegler
    Centre National de la Recherche Scientifique and Université de Provence, Marseille, France
    Psychol Bull 131:3-29. 2005
    ..lexical representations and accompanying differences in developmental reading strategies and the manifestation of dyslexia across orthographies...
  14. ncbi The magnocellular theory of developmental dyslexia
    J Stein
    University Laboratory of Physiology, Oxford, UK
    Dyslexia 7:12-36. 2001
    Low literacy is termed 'developmental dyslexia' when reading is significantly behind that expected from the intelligence quotient (IQ) in the presence of other symptoms--incoordination, left-right confusions, poor sequencing--that ..
  15. ncbi Orienting of visual attention in dyslexia: evidence for asymmetric hemispheric control of attention
    A Facoetti
    General Psychology Department, University of Padova, Via Venezia 8, 35131 Padova, Italy
    Exp Brain Res 138:46-53. 2001
    The control of attentional orienting was studied in children with specific reading disorder (SRD) or dyslexia, and it was compared with that of normal readers...
  16. pmc Exploring the transcriptome of ciliated cells using in silico dissection of human tissues
    Alexander E Ivliev
    A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow, Russia
    PLoS ONE 7:e35618. 2012
    ..The novel findings included a set of genes (DCDC2, DYX1C1, KIAA0319) related to a neurological disease dyslexia suggesting their potential involvement in ciliary functions...
  17. ncbi Reduced phase locking to slow amplitude modulation in adults with dyslexia: an MEG study
    Jarmo A Hämäläinen
    Centre for Neuroscience in Education, Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Neuroimage 59:2952-61. 2012
    ..Individuals with developmental dyslexia have difficulty in the accurate neural representation of phonological aspects of speech, across languages...
  18. ncbi Family risk of dyslexia is continuous: individual differences in the precursors of reading skill
    Margaret J Snowling
    Department of Psychology, University of York, Heslington, United Kingdom
    Child Dev 74:358-73. 2003
    The development of 56 children at family risk of dyslexia was followed from the age of 3 years, 9 months to 8 years...
  19. ncbi TDT-association analysis of EKN1 and dyslexia in a Colorado twin cohort
    Haiying Meng
    Department of Pediatrics, Yale Child Health Research Center, Yale University School of Medicine, 464 Congress Avenue, New Haven, CT 06520 8081, USA
    Hum Genet 118:87-90. 2005
    A candidate gene, EKN1, was recently described in a cohort from Finland for the dyslexia locus on chromosome 15q, DYX1...
  20. ncbi Relations among speech, language, and reading disorders
    Bruce F Pennington
    Department of Psychology, University of Denver, Colorado 80208, USA
    Annu Rev Psychol 60:283-306. 2009
    ..We evaluate which comorbidity models can be rejected or supported as explanations for why and how these three disorders overlap and what new data are needed to better define their relations...
  21. ncbi Further evidence for DYX1C1 as a susceptibility factor for dyslexia
    Faten Dahdouh
    Institute of Human Genetics, Life and Brain Center, University of Bonn, Bonn, Germany
    Psychiatr Genet 19:59-63. 2009
    b>Dyslexia-susceptibility-1-candidate-1 (DYX1C1) was the first gene associated with dyslexia. Since the original report of 2003, eight replication attempts have been published reporting discordant results...
  22. ncbi A theoretical molecular network for dyslexia: integrating available genetic findings
    G Poelmans
    Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mol Psychiatry 16:365-82. 2011
    Developmental dyslexia is a common specific childhood learning disorder with a strong heritable component. Previous studies using different genetic approaches have identified several genetic loci and candidate genes for dyslexia...
  23. ncbi The eye movements of dyslexic children during reading and visual search: impact of the visual attention span
    Chloé Prado
    Laboratoire de Psychologie et Neuro Cognition UMR5105 CNRS, Université Pierre Mendès France, 1251 Avenue Centrale BP 47, 38040 Grenoble Cedex 9, France
    Vision Res 47:2521-30. 2007
    ..The atypical eye movements of some dyslexic readers in reading thus appear to reflect difficulties to increase their VA span according to the task request...
  24. ncbi From single to multiple deficit models of developmental disorders
    Bruce F Pennington
    Department of Psychology, University of Denver, 2155 S Race St, Denver, CO 80208, USA
    Cognition 101:385-413. 2006
    The emerging etiological model for developmental disorders, like dyslexia, is probabilistic and multifactorial while the prevailing cognitive model has been deterministic and often focused on a single cognitive cause, such as a ..
  25. ncbi Implicit learning deficits in dyslexic adults: an fMRI study
    Deny Menghini
    IRCCS, Children s Hospital Bambino Gesu, Santa Marinella, Rome, Italy IRCCS, Santa Lucia Foundation, Rome, Italy
    Neuroimage 33:1218-26. 2006
    ..that several neuropsychological impairments characterize the cognitive profile of individuals with developmental dyslexia (DD)...
  26. ncbi Theories of developmental dyslexia: insights from a multiple case study of dyslexic adults
    Franck Ramus
    Institute of Cognitive Neuroscience, University College London, London, UK
    Brain 126:841-65. 2003
    A multiple case study was conducted in order to assess three leading theories of developmental dyslexia: (i) the phonological theory, (ii) the magnocellular (auditory and visual) theory and (iii) the cerebellar theory...
  27. ncbi Dyslexia and dyscalculia: two learning disorders with different cognitive profiles
    Karin Landerl
    Department of Psychology, University of Tuebingen, Tuebingen, Germany
    J Exp Child Psychol 103:309-24. 2009
    This study tests the hypothesis that dyslexia and dyscalculia are associated with two largely independent cognitive deficits, namely a phonological deficit in the case of dyslexia and a deficit in the number module in the case of ..
  28. ncbi Perception of patterns of musical beat distribution in phonological developmental dyslexia: significant longitudinal relations with word reading and reading comprehension
    Usha Goswami
    Centre for Neuroscience in Education, University of Cambridge, Cambridge, UK
    Cortex 49:1363-76. 2013
    ..of musical meter') accounted for over 40% of the variance in single word reading in children with and without dyslexia (Huss et al., 2011)...
  29. ncbi Dyslexia in regular orthographies: manifestation and causation
    Heinz Wimmer
    Department of Psychology, Center for Neurocognitive Research, University of Salzburg, Austria
    Dyslexia 16:283-99. 2010
    This article summarizes our research on the manifestation of dyslexia in German and on cognitive deficits, which may account for the severe reading speed deficit and the poor orthographic spelling performance that characterize dyslexia in ..
  30. ncbi Deficits in beat perception and dyslexia: evidence from French
    Mathilde Muneaux
    Laboratoire de Psychologie Cognitive, CNRS and Université de Provence, Case 66, 3 Place Victor Hugo, 13331 Marseille Cedex 3, France
    Neuroreport 15:1255-9. 2004
    ..The results suggest that deficits in the perception of cues important for speech rhythm may be universal in developmental dyslexia.
  31. ncbi DRC: a dual route cascaded model of visual word recognition and reading aloud
    M Coltheart
    Macquarie Centre for Cognitive Science, Macquarie University, Sydney, NSW 2109, Australia
    Psychol Rev 108:204-56. 2001
    ..The authors conclude that the DRC model is the most successful of the existing computational models of reading...
  32. ncbi Adults with dyslexia exhibit large effects of crowding, increased dependence on cues, and detrimental effects of distractors in visual search tasks
    Elisabeth Moores
    School of Life and Health Sciences, Psychology, Aston University, Aston Triangle, Birmingham B4 7ET, United Kingdom
    Neuropsychologia 49:3881-90. 2011
    Difficulties in visual attention are increasingly being linked to dyslexia. To date, the majority of studies have inferred functionality of attention from response times to stimuli presented for an indefinite duration...
  33. ncbi Altered low-γ sampling in auditory cortex accounts for the three main facets of dyslexia
    Katia Lehongre
    Inserm U960 École Normale Supérieure, 75005 Paris, France
    Neuron 72:1080-90. 2011
    It has recently been conjectured that dyslexia arises from abnormal auditory sampling. What sampling rate is altered and how it affects reading remains unclear...
  34. ncbi Integration of proprioceptive signals and attentional capacity during postural control are impaired but subject to improvement in dyslexic children
    Patrick Quercia
    Departement d Ophtalmologie, CHU, Dijon, France
    Exp Brain Res 209:599-608. 2011
    Children with developmental dyslexia suffer from delayed reading capabilities and may also exhibit attentional and sensori-motor deficits. The objective of this study was twofold...
  35. ncbi Meta-analyzing brain dysfunctions in dyslexic children and adults
    Fabio Richlan
    Department of Psychology and Center for Neurocognitive Research, University of Salzburg, Salzburg, Austria
    Neuroimage 56:1735-42. 2011
    ..These meta-analytic results are consistent with recent findings speaking for an early engagement of left OT regions in reading development and for an early failure of such an engagement in dyslexia.
  36. ncbi The pathophysiology of letter-by-letter reading
    Laurent Cohen
    Institut de Neurologie, Hopital de la Salpetriere, 47 83 Bd de l Hopital, 75651 Paris Cedex 13, France
    Neuropsychologia 42:1768-80. 2004
    ....
  37. ncbi Practitioner Review: Reading disorders: what are the effective interventions and how should they be implemented and evaluated?
    Fiona J Duff
    Psychology Department, University of York, Heslington, York, UK
    J Child Psychol Psychiatry 52:3-12. 2011
    Two developmental reading disorders, dyslexia and reading comprehension impairment, are identified by different behavioural characteristics and traced back to different underlying cognitive impairments...
  38. ncbi Uncoupling of reading and IQ over time: empirical evidence for a definition of dyslexia
    Emilio Ferrer
    Department of Psychology, University of California, Davis, Davis, CA 95616 8686, USA
    Psychol Sci 21:93-101. 2010
    Developmental dyslexia is defined as an unexpected difficulty in reading in individuals who otherwise possess the intelligence and motivation considered necessary for fluent reading, and who also have had reasonable reading instruction...
  39. ncbi Comorbidity of learning disorders: prevalence and familial transmission
    Karin Landerl
    University of Tuebingen, 72072 Tuebingen, Germany
    J Child Psychol Psychiatry 51:287-94. 2010
    ..So far, empirical evidence on comorbidities of specific learning disorders in arithmetic, reading and spelling is scarce...
  40. pmc Reading text increases binocular disparity in dyslexic children
    Julie A Kirkby
    Psychology Department, Bournemouth University, Bournemouth, United Kingdom
    PLoS ONE 6:e27105. 2011
    Children with developmental dyslexia show reading impairment compared to their peers, despite being matched on IQ, socio-economic background, and educational opportunities...
  41. ncbi Eye movements of dyslexic children when reading in a regular orthography
    Florian Hutzler
    Department of Psychology, University of Salzburg, Salzburg, Austria
    Brain Lang 89:235-42. 2004
    ....
  42. ncbi Poor saccadic control correlates with dyslexia
    M Biscaldi
    Brain Research Unit, Institute of Biophysics, University of Freiburg, Germany
    Neuropsychologia 36:1189-202. 1998
    ..Yet, the development was slower in group D1. It is suggested that reading process and saccade system are both controlled by visuo spatial attention and fixation systems that maybe impaired or develop slowly in many dyslexic subjects...
  43. ncbi No support for association between dyslexia susceptibility 1 candidate 1 and developmental dyslexia
    N A Cope
    Mol Psychiatry 10:237-8. 2005
  44. ncbi Evaluation of candidate genes for DYX1 and DYX2 in families with dyslexia
    Zoran Brkanac
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 98198 7720, USA
    Am J Med Genet B Neuropsychiatr Genet 144:556-60. 2007
    b>Dyslexia is a common heterogeneous disorder with a significant genetic component. Multiple studies have replicated the evidence for linkage between variously defined phenotypes of dyslexia and chromosomal regions on 15q21 (DYX1) and 6p22...
  45. pmc Dyslexia and DCDC2: normal variation in reading and spelling is associated with DCDC2 polymorphisms in an Australian population sample
    Penelope A Lind
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Eur J Hum Genet 18:668-73. 2010
    The 6p21-p22 chromosomal region has been identified as a developmental dyslexia locus both in linkage and association studies, the latter generating evidence for the doublecortin domain containing 2 (DCDC2) as a candidate gene at this ..
  46. ncbi Auditory processing deficits in dyslexia: task or stimulus related?
    Karen Banai
    Department of Neurobiology, Hebrew University of Jerusalem, Jerusalem, Israel
    Cereb Cortex 16:1718-28. 2006
    ..In both cases, the extent of difficulties is determined by the structure of the task rather than by stimulus composition or complexity...
  47. pmc A common variant associated with dyslexia reduces expression of the KIAA0319 gene
    Megan Y Dennis
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    PLoS Genet 5:e1000436. 2009
    Numerous genetic association studies have implicated the KIAA0319 gene on human chromosome 6p22 in dyslexia susceptibility...
  48. ncbi Crowding effects on word identification in developmental dyslexia
    Donatella Spinelli-
    IUSM, Roma, Italy
    Cortex 38:179-200. 2002
    ..effect of crowding on the identification of words was examined in normal readers and subjects with developmental dyslexia. In Experiment 1, a matching task was used. Words were presented either alone or embedded in other words...
  49. ncbi The left occipitotemporal system in reading: disruption of focal fMRI connectivity to left inferior frontal and inferior parietal language areas in children with dyslexia
    Sanne van der Mark
    MR Center, University Children s Hospital, University of Zurich, Zurich, Switzerland
    Neuroimage 54:2426-36. 2011
    Developmental dyslexia is a severe reading disorder, which is characterized by dysfluent reading and impaired automaticity of visual word processing...
  50. ncbi Developmental dyslexia: the cerebellar deficit hypothesis
    R I Nicolson
    Dept of Psychology, University of Sheffield, S10 2TP, Sheffield, UK
    Trends Neurosci 24:508-11. 2001
    ..Specific behavioural and neuroimaging tests reviewed here indicate that dyslexia is indeed associated with cerebellar impairment in about 80% of cases...
  51. pmc A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain
    Mikko Taipale
    Department of Medical Genetics, University of Helsinki, 00014 Helsinki, Finland
    Proc Natl Acad Sci U S A 100:11553-8. 2003
    ..locus in chromosome 15q21, that is disrupted by a translocation t(2;15)(q11;q21) segregating coincidentally with dyslexia. Two sequence changes in DYX1C1, one involving the translation initiation sequence and an Elk-1 transcription ..
  52. pmc The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia
    Katariina Hannula-Jouppi
    Department of Medical Genetics, University of Helsinki, Finland
    PLoS Genet 1:e50. 2005
    b>Dyslexia, or specific reading disability, is the most common learning disorder with a complex, partially genetic basis, but its biochemical mechanisms remain poorly understood...
  53. ncbi Developmental dyslexia and specific language impairment: same or different?
    Dorothy V M Bishop
    Department of Experimental Psychology, Oxford University, Oxford, United Kingdom
    Psychol Bull 130:858-86. 2004
    Developmental dyslexia and specific language impairment (SLI) were for many years treated as distinct disorders but are now often regarded as different manifestations of the same underlying problem, differing only in severity or ..
  54. ncbi Rhythmic processing in children with developmental dyslexia: auditory and motor rhythms link to reading and spelling
    Jennifer M Thomson
    Centre for Neuroscience in Education, University of Cambridge, 184 Hills Road, Cambridge, CB2 2PQ, UK
    J Physiol Paris 102:120-9. 2008
    ..g., [Wolff, P.H., 2002. Timing precision and rhythm in developmental dyslexia. Reading and Writing, 15 (1), 179-206.] between motor tapping and written language skills...
  55. ncbi Specialization within the ventral stream: the case for the visual word form area
    Laurent Cohen
    Neuroimage 22:466-76. 2004
    ..We conclude that learning to read results in the progressive development of an inferotemporal region increasingly responsive to visual words, which is aptly named the visual word form area (VWFA)...
  56. ncbi Neural correlates of rapid auditory processing are disrupted in children with developmental dyslexia and ameliorated with training: an fMRI study
    N Gaab
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA
    Restor Neurol Neurosci 25:295-310. 2007
    Developmental dyslexia, characterized by unexpected difficulty in reading, may involve a fundamental deficit in processing rapid acoustic stimuli...
  57. ncbi Specific reading disability (dyslexia): what have we learned in the past four decades?
    Frank R Vellutino
    The State University of New York at Albany, Child Research and Study Center, Department of Educational Psychology and Statistics, New York 12222, USA
    J Child Psychol Psychiatry 45:2-40. 2004
    ..of the most important findings from research evaluating the hypothesized causes of specific reading disability ('dyslexia') over the past four decades...
  58. pmc Investigation of dyslexia and SLI risk variants in reading- and language-impaired subjects
    D F Newbury
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    Behav Genet 41:90-104. 2011
    b>Dyslexia (or reading disability) and specific language impairment (or SLI) are common childhood disorders that show considerable co-morbidity and diagnostic overlaps and have been suggested to share some genetic aetiology...
  59. pmc Persistent spatial working memory deficits in rats following in utero RNAi of Dyx1c1
    C E Szalkowski
    Department of Psychology Behavioral Neuroscience, University of Connecticut, 406 Babbidge Road, Storrs, CT 06269, USA
    Genes Brain Behav 10:244-52. 2011
    ..include evidence that variants in the human gene DYX1C1 may be associated with an increased risk of developmental dyslexia. Concurrent research has shown that the rat homolog for this gene modulates critical parameters of early cortical ..
  60. ncbi The cognitive deficits responsible for developmental dyslexia: review of evidence for a selective visual attentional disorder
    Sylviane Valdois
    Laboratoire de Psychologie et Neuro Cognition UMR 5105 CNRS, Université Pierre Mendès France, Grenoble, France
    Dyslexia 10:339-63. 2004
    There is strong converging evidence suggesting that developmental dyslexia stems from a phonological processing deficit...
  61. ncbi Prevalence of combined reading and arithmetic disabilities
    Evelien Dirks
    Department of Special Education, VU University of Amsterdam, The Netherlands
    J Learn Disabil 41:460-73. 2008
    ..This might imply that differ processes underlie the relationship between arithmetic and word recognition disabilities compared to the relationship arithmetic disabilities with difficulties in spelling and reading comprehension...
  62. ncbi Right fronto-parietal dysfunction in children with ADHD and developmental dyslexia as determined by line bisection judgements
    Karen E Waldie
    Department of Psychology, University of Auckland, Auckland, New Zealand
    Neuropsychologia 48:3650-6. 2010
    ..In this study children with ADHD were matched with children with developmental dyslexia on IQ and gender to test the hypothesis that right hemisphere neurological abnormalities underlie the behavioural ..
  63. ncbi Genetic variant in KIAA0319, but not in DYX1C1, is associated with risk of dyslexia: an integrated meta-analysis
    Li Zou
    Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huangzhong University of Science and Technology, Wuhan, China
    Am J Med Genet B Neuropsychiatr Genet 159:970-6. 2012
    DYX1C1 and KIAA0319 have been two of the most extensively studied candidate genes for dyslexia given their important roles in the neuronal migration and neurite growth...
  64. ncbi Working memory, short-term memory, and reading disabilities: a selective meta-analysis of the literature
    H Lee Swanson
    Graduate School of Education, Educational Psychology, University of California Riverside, CA 92521, USA
    J Learn Disabil 42:260-87. 2009
    ....
  65. ncbi Sex differences in developmental reading disability: new findings from 4 epidemiological studies
    Michael Rutter
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, Denmark Hill, London, England
    JAMA 291:2007-12. 2004
    ..An influential article published in 1990 claimed that the increased rate of reading disability in boys was a consequence of referral bias...
  66. pmc Cognitive profile of students who enter higher education with an indication of dyslexia
    Maaike Callens
    Department of Experimental Psychology, University of Ghent, Ghent, Belgium
    PLoS ONE 7:e38081. 2012
    ..lack of empirical evidence about the cognitive profile of students entering higher education with a diagnosis of dyslexia. To obtain such evidence, we compared a group of 100 Dutch-speaking students diagnosed with dyslexia with a ..
  67. ncbi Behavioral and ERP evidence for amodal sluggish attentional shifting in developmental dyslexia
    Marie Lallier
    Laboratoire de Psychologie et NeuroCognition, Université Pierre Mendès France, Grenoble, France
    Neuropsychologia 48:4125-35. 2010
    ..deficits in attentional shifting may be the source of reading acquisition disorders in phonological developmental dyslexia (sluggish attentional shifting, SAS, theory, Hari & Renvall, 2001)...
  68. ncbi The attentional blink reveals sluggish attentional shifting in adolescents with specific language impairment
    Jarrad A G Lum
    School of Psychological Sciences, The University of Manchester, UK
    Brain Cogn 63:287-95. 2007
    ..Hari and Renvall (2001) [Hari, R. & Renvall, H. (2001). Impaired processing of rapid stimulus sequences in dyslexia. Trends in cognitive sciences, 5, 525-532...
  69. ncbi Psychophysical evidence for a general temporal processing deficit in children with dyslexia
    M Van Ingelghem
    Section of Orthopedagogics, Katholieke Universiteit Leuven, Vesaliusstraat 2, B-3000 Leuven, Belgium
    Neuroreport 12:3603-7. 2001
    The hypothesis of a general (i.e. cross-modal) temporal processing deficit in dyslexia was tested by examining rapid processing in both the auditory and the visual system in the same children with dyslexia...
  70. ncbi Dyslexia: a deficit in visuo-spatial attention, not in phonological processing
    Trichur R Vidyasagar
    Department of Optometry and Vision Sciences, University of Melbourne, Parkville, VIC 3010, Australia
    Trends Cogn Sci 14:57-63. 2010
    Developmental dyslexia affects up to 10 per cent of the population and it is important to understand its causes...
  71. ncbi Word, nonword, and visual paired associate learning in Dutch dyslexic children
    Vera C S Messbauer
    Department of Education, Faculty of Social and Behavioural Sciences, University of Amsterdam, PO Box 94208, 1090 GE, Amsterdam, The Netherlands
    J Exp Child Psychol 84:77-96. 2003
    ..Finally, phonological awareness ability was assessed. Dyslexics performed worse than age-matched normal readers, but similar to reading-age controls...
  72. ncbi Quantitative trait locus association scan of early reading disability and ability using pooled DNA and 100K SNP microarrays in a sample of 5760 children
    E L Meaburn
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London, UK
    Mol Psychiatry 13:729-40. 2008
    ..We conclude that QTL effect sizes, even for highly heritable common disorders and quantitative traits such as early reading disability and ability, might be much smaller than previously considered...
  73. ncbi Fractionating the multi-character processing deficit in developmental dyslexia: Evidence from two case studies
    Matthieu Dubois
    Cognition and Development Lab, Catholic University of Louvain, Louvain la Neuve, Belgium
    Cortex 46:717-38. 2010
    ..Possible relations between these impairments and learning to read proficiently are discussed...
  74. pmc DCDC2 genetic variants and susceptibility to developmental dyslexia
    Cecilia Marino
    Department of Child Psychiatry, Scientific Institute Eugenio Medea, Bosisio Parini, Italy
    Psychiatr Genet 22:25-30. 2012
    Developmental dyslexia is a heritable condition, with genetic factors accounting for 44-75% of the variance in performance tests of reading component subphenotypes...
  75. ncbi Rapid processing of letters, digits and symbols: what purely visual-attentional deficit in developmental dyslexia?
    Johannes C Ziegler
    Departement de Psychologie, Aix Marseille Universite, France
    Dev Sci 13:F8-F14. 2010
    Visual-attentional theories of dyslexia predict deficits for dyslexic children not only for the perception of letter strings but also for non-alphanumeric symbol strings...
  76. pmc Are specific language impairment and dyslexia distinct disorders?
    Hugh W Catts
    Department of Speech Language Hearing, University of Kansas, Lawrence 66045, USA
    J Speech Lang Hear Res 48:1378-96. 2005
    The purpose of this study was to determine whether specific language impairment (SLI) and dyslexia are distinct developmental disorders.
  77. ncbi Phonological training in children with dyslexia using temporally modified speech: a three-step pilot investigation
    Michel Habib
    Faculty of Medicine, CHU Timone, Marseille, France
    Int J Lang Commun Disord 37:289-308. 2002
    ..studies were successively carried out to investigate the usefulness of intensively training children with dyslexia with daily exercizes based on the temporal processing theory of dyslexia, according to which these children would ..
  78. pmc Unstable representation of sound: a biological marker of dyslexia
    Jane Hornickel
    Auditory Neuroscience Laboratory, Department of Communication Sciences and Disorders, Northwestern University, Evanston, Illinois 60208, USA
    J Neurosci 33:3500-4. 2013
    ..Thus, neural variability may be an underlying biological contributor to well established behavioral and neural deficits found in poor readers...
  79. ncbi A qualitative and quantitative review of diffusion tensor imaging studies in reading and dyslexia
    Maaike Vandermosten
    Parenting and Special Education Research Unit, KU Leuven, L Vanderkelenstraat 32, 3000 Leuven, Belgium
    Neurosci Biobehav Rev 36:1532-52. 2012
    In this review paper we address whether deficits in reading (i.e. developmental dyslexia) are rooted in neurobiological anomalies in white matter tracts...
  80. ncbi Eye movement patterns in linguistic and non-linguistic tasks in developmental surface dyslexia
    M De Luca
    Neuropsychological Research Unit, IRCCS Ospedale S Lucia, Rome, Italy
    Neuropsychologia 37:1407-20. 1999
    ..Longer words showed a higher number of fixations. Overall, it was concluded that surface dyslexia is not associated with oculo-motor dysfunction and the study of eye movements in reading reveals the processing ..
  81. ncbi Development of left occipitotemporal systems for skilled reading in children after a phonologically- based intervention
    Bennett A Shaywitz
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06510 8064, USA
    Biol Psychiatry 55:926-33. 2004
    ..In this study, we hypothesized that the provision of an evidence-based, phonologically mediated reading intervention would improve reading fluency and the development of the fast-paced occipitotemporal systems serving skilled reading...
  82. ncbi Tachistoscopic treatment of dyslexia changes the distribution of visual-spatial attention
    Maria Luisa Lorusso
    Unità di Psicologia e Neuropsicologia Cognitiva, IRCCS E Medea, Bosisio Parini, Lecco, Italy
    Brain Cogn 57:135-42. 2005
    Twelve children with developmental dyslexia underwent a four-month treatment with tachistoscopic presentation of words, according to Bakker's methodology...
  83. ncbi A visual processing but no phonological disorder in a child with mixed dyslexia
    Sylviane Valdois
    Laboratoire de Psychologie et Neuro Cognition UMR 5105 CNRS, Université Pierre Mendès France, Grenoble, France
    Cortex 47:1197-218. 2011
    The case study of Martial, a French 9-year-old boy, who exhibits severe mixed dyslexia and surface dysgraphia is reported...
  84. ncbi Executive functions in children with dyslexia
    Astrid Reiter
    Department of Experimental Psychology, University of Regensburg, 93040 Regensburg, Germany
    Dyslexia 11:116-31. 2005
    There is little data available concerning the executive functions of children with dyslexia. The small number of existing studies in this field focus on single aspects of these functions such as working memory...
  85. ncbi Interrelationship and familiality of dyslexia related quantitative measures
    G Schulte-Körne
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany
    Ann Hum Genet 71:160-75. 2007
    b>Dyslexia is a complex gene-environment disorder with poorly understood etiology that affects about 5% of school-age children...
  86. ncbi Neural dissociation of phonological and visual attention span disorders in developmental dyslexia: FMRI evidence from two case reports
    C Peyrin
    CNRS UMR 5105, 38040 Grenoble, France
    Brain Lang 120:381-94. 2012
    ..dissociation has a neurobiological counterpart through the investigation of two cases of developmental dyslexia. LL showed a phonological disorder but preserved VA span whereas FG exhibited the reverse pattern...
  87. ncbi Reading and dual-task balancing: evidence against the automatization deficit explanation of developmental dyslexia
    H Wimmer
    Department of Psychology, University of Salzburg, Austria
    J Learn Disabil 32:473-8. 1999
    Nicolson and Fawcett (1990) demonstrated specifically impaired balancing performance of children with dyslexia when balancing had to be done simultaneously with a secondary task...
  88. ncbi Neurobiology of dyslexia: a reinterpretation of the data
    Franck Ramus
    Laboratoire de Sciences Cognitives et Psycholinguistique EHESS CNRS ENS, 46 rue d Ulm, 75230 Paris Cedex 5, France
    Trends Neurosci 27:720-6. 2004
    Theories of developmental dyslexia differ on how to best interpret the great variety of symptoms (linguistic, sensory and motor) observed in dyslexic individuals...
  89. pmc Dyslexic children are confronted with unstable binocular fixation while reading
    Stephanie Jainta
    IRIS laboratory CNRS Assistance Publique Hôpitaux de Paris, Paris, France
    PLoS ONE 6:e18694. 2011
    ....
  90. ncbi Atypical brain responses to sounds in children with specific language and reading impairments
    Genevieve McArthur
    Macquarie Centre for Cognitive Science, Macquarie University, NSW, Australia
    Dev Sci 12:768-83. 2009
    ..A subgroup of these poor non-word readers also had poor non-word repetition. These findings support the hypothesis that impaired auditory processing is a causal risk factor for both SLI and SRD...
  91. ncbi Paying attention to reading: the neurobiology of reading and dyslexia
    Sally E Shaywitz
    Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Dev Psychopathol 20:1329-49. 2008
    ..Scientists now speak of the neural signature of dyslexia, a singular achievement that for the first time has made what was previously a hidden disability, now visible...
  92. ncbi Superior parietal lobule dysfunction in a homogeneous group of dyslexic children with a visual attention span disorder
    C Peyrin
    Laboratoire de Psychologie et NeuroCognition UMR 5105 CNRS, Université Pierre Mendès France, 38040 Grenoble Cedex 09, France
    Brain Lang 118:128-38. 2011
    ..These findings provide new insights on the role of parietal regions, in particular the left superior parietal lobule, in the visual attention span and in developmental dyslexia.
  93. ncbi Ameliorating children's reading-comprehension difficulties: a randomized controlled trial
    Paula J Clarke
    University of York, York YO10 5DD, United Kingdom
    Psychol Sci 21:1106-16. 2010
    ..We conclude that specific reading-comprehension difficulties reflect (at least partly) underlying oral-language weaknesses that can be effectively ameliorated by suitable teaching...
  94. ncbi First genome-wide association scan on neurophysiological endophenotypes points to trans-regulation effects on SLC2A3 in dyslexic children
    D Roeske
    Max Planck Institute of Psychiatry, Munich, Germany
    Mol Psychiatry 16:97-107. 2011
    b>Dyslexia is one of the most common learning disorders affecting about 5% of all school-aged children. It has been shown that event-related potential measurements reveal differences between dyslexic children and age-matched controls...
  95. ncbi The neural signature of orthographic-phonological binding in successful and failing reading development
    Leo Blomert
    Dept Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, The Netherlands
    Neuroimage 57:695-703. 2011
    ..a specific orthographic-phonological binding deficit may not only act as a proximal cause for reading deficits in dyslexia, but may also explain the notorious lack of reading fluency...
  96. ncbi A tractography study in dyslexia: neuroanatomic correlates of orthographic, phonological and speech processing
    Maaike Vandermosten
    Parenting and Special Education Research Unit, Katholieke Universiteit Leuven, Leuven, Belgium
    Brain 135:935-48. 2012
    ..In the present study, 20 adults with dyslexia and 20 typical reading adults were scanned using diffusion tensor imaging, and the bilateral arcuate fasciculus ..
  97. ncbi Impaired balance in developmental dyslexia? A meta-analysis of the contending evidence
    Kim S H Rochelle
    School of Life and Health Sciences, Psychology, Aston University, Birmingham, UK
    J Child Psychol Psychiatry 47:1159-66. 2006
    Developmental dyslexia is typically defined by deficits in phonological skills, but it is also associated with anomalous performance on measures of balance...
  98. ncbi The gradient of visual attention in developmental dyslexia
    A Facoetti
    Dipartimento di Psicologia Generale, Universita degli Studi di Padova, Padova, Italy
    Neuropsychologia 39:352-7. 2001
    ..investigated the gradient of visual attention in 21 children, 11 children with specific reading disorder (SRD) or dyslexia and 10 children with normal reading skills...
  99. ncbi Disabled readers suffer from visual and auditory impairments but not from a specific magnocellular deficit
    Sygal Amitay
    Departments of Neurobiology and Psychology, Interdisciplinary Center for Neural Computation, The Hebrew University of Jerusalem, Israel
    Brain 125:2272-85. 2002
    ..Many RD subjects have more specific perceptual deficits; however, the "magnocellular" level of description did not capture the nature of the perceptual difficulties in any of the RD individuals assessed by us...
  100. ncbi ERP evidence for the split fovea theory
    Clara D Martin
    Laboratoire Langage Cerveau et Cognition, Institut des Sciences Cognitives, CNRS, 67 Bd Pinel, 69675 Bron Cedex, France
    Brain Res 1185:212-20. 2007
    ..Ten control participants and ten participants with developmental dyslexia undergoing electroencephalographic recordings were asked to identify one of five letters in a string...
  101. pmc Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia
    Natalie Cope
    Department of Psychological Medicine, Wales College of Medicine, Cardiff University, Cardiff, United Kingdom
    Am J Hum Genet 76:581-91. 2005
    Linkage between developmental dyslexia (DD) and chromosome 6p has been replicated in a number of independent samples...

Research Grants74

  1. Molecular Diagnosis of Dyslexia
    Seiyu Hosono; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Reading disability (RD), also known as dyslexia, is the most common learning disability affecting school children...
  2. NIRS Optical Topography System - Hitachi ETG-4000
    Allan Reiss; Fiscal Year: 2007
    ..cognitive impairment and Alzheimer's disease), preterm infants and learning disabilities (developmental dyslexia)...
  3. Feature selectivity of auditory thalamus
    Edward Bartlett; Fiscal Year: 2005
    ..Some deficits observed in humans with dyslexia and schizophrenia have been correlated with abnormalities in the MGB...
  4. EEG Synchrony, perinatal risk and outcome: analysis of CHIME data
    PHILIP GEORGE GRIEVE; Fiscal Year: 2010
    ..for cerebral palsy (CP), developmental delay, and sensory-motor deficits in infancy and learning disabilities, dyslexia, and hyperactivity-inattention syndromes at school age...
  5. MRDD Research Center
    KARL PFENNINGER; Fiscal Year: 2009
    ..in exploring the genes responsible for single and multigene disorders: autism, Down syndrome, fragile X syndrome, dyslexia, attention deficit hyperactivity disorder, and schizophrenia...
  6. DETERMINATION OF NEURONAL FATES IN VISUAL CORTEX
    Susan K McConnell; Fiscal Year: 2013
    ..the migration and connectivity of cortical neurons are associated with a variety of disorders including epilepsy, dyslexia, schizophrenia, bipolar affective illness, and autism...
  7. Foxp2 regulation of sex specific transcriptional pathways and brain development
    JERALD MICHAEL BOWERS; Fiscal Year: 2013
    ..exhibit far higher rates of autism and autism spectrum disorder (ASD), Tourette's Syndrome, stuttering, dyslexia, and early onset of schizophrenia, all of which have a childhood onset...
  8. Estradiol, GABA and Developing Hippocampal Cells
    JERALD MICHAEL BOWERS; Fiscal Year: 2011
    ..Males exhibit far higher rates of autism and autism spectrum disorder, Tourette's Syndrome, stuttering, dyslexia, and early onset of schizophrenia, all of which have a childhood onset...
  9. Investigating readout of cerebellar synchrony in delay eyeblink conditioning
    ALEXANDER D KLOTH; Fiscal Year: 2013
    ..dystonia, but may also involve cognitive disorders that have well-known cerebellar anatomical deficits, such as dyslexia, attentive-deficit/hyperactivity disorder, and autism...
  10. A MICRO-ELECTRODE STUDY OF OXYGEN-BASED FUNCTIONAL CONNECTIVITY
    Lawrence H Snyder; Fiscal Year: 2012
    ..fluctuations;brain injuries perturb resting state networks;and multiple clinical disorders, including depression, dyslexia and prosopagnosia, are associated with specific resting state network abnormalities...
  11. The role of GABAB signaling during axon guidance in the developing zebrafish
    ALEMJI TAKU; Fiscal Year: 2011
    ..are involved in axon guidance have been linked to neurological diseases such as mental retardation, epilepsy, dyslexia, autism, Parkinson's, and Amyotrophic lateral sclerosis (reviewed in Yaron and Zheng, 2006;Anitha et al...
  12. NEUROGENETIC PROCESSES IN THE FETAL BRAIN
    Pasko Rakic; Fiscal Year: 2013
    ..a variety of cognitive disorders with unknown pathology, such as autism, childhood epilepsy, developmental dyslexia, schizophrenia and mental retardation...
  13. Origin of Cortical Species-specific Distinctions
    Pasko Rakic; Fiscal Year: 2012
    ..cortex can give rise to uniquely human neuropsychiatric disorders such as schizophrenia, autism, developmental dyslexia, mental retardation and response to drugs for therapy and abuse...
  14. A Familial Study of Severe Phonology Disorders
    Barbara A Lewis; Fiscal Year: 2012
    ..and genetic overlap of SSD, RD, and LI and we test the hypothesis that neurally expressed genes identified for dyslexia are also associated with SSD...
  15. NEUROBIOLOGY OF CORTICAL SYSTEMS
    MICHAEL CRAIR; Fiscal Year: 2013
    ..RELEVANCE: This training program fosters education on brain disorders such as dyslexia, autism, Tourette's Syndrome, Attention Deficit Hyperactivity Disorder, epilepsy, cerebral palsy, dementias (..
  16. Synaptic mechanisms of temporal pattern recognition
    Christa A Baker; Fiscal Year: 2012
    ..Disruptions in the auditory processing of timing and novelty cues have been implicated in dyslexia, Central Auditory Processing Disorder, and autism...
  17. Identification of homologues of the Commissureless protein
    Thomas Kidd; Fiscal Year: 2012
    ..genetic variants of Robo receptors have been implicated in such diverse conditions as scoliosis and developmental dyslexia. To date, comm genes have not been found outside of insects...
  18. Accelerated Software Tools for Neuroimaging Analysis
    Bruce Fischl; Fiscal Year: 2011
    ..such as schizophrenia, Huntington's disease, Alzheimer's disease, Semantic Dementia, phobias, autism, dyslexia, aging, and development...
  19. G-protein-coupled Receptors in Hearing Physiology
    Yong Lu; Fiscal Year: 2012
    ..signal processing/temporal coding, and help lay the groundwork for decisions about possible therapeutic approaches to hearing defects related to altered synaptic transmission, such as dyslexia, tinnitus, and age-related hearing loss.
  20. Processing Streams in the Cerebral Cortex
    Josef P Rauschecker; Fiscal Year: 2013
    ..The studies are also relevant for disorders such as dyslexia and autism, which include problems in language comprehension or ability for social communication...
  21. The Molecular roles of Filamin A and Arfgef2 in cortical development
    JASON B NEAL; Fiscal Year: 2010
    ..the brain suggesting defects in neuronal migration 2) microcephaly, suggesting defects in neural proliferation 3) dyslexia, suggesting abberent cortical connectivity...
  22. Using Cognitive Neuroscience to Predict Dyslexia among Kindergarden Children
    John Gabrieli; Fiscal Year: 2013
    ..by applicant): The long-term objective of this research is to understand the brain basis of developmental dyslexia, one of the most common specific learning disabilities, and to advance early identification of dyslexia so that ..
  23. Steroid Receptors and Brain Sex Differences
    Anthony P Auger; Fiscal Year: 2010
    ..Men are more likely to exhibit signs of attention-deficit hyperactivity, autism, and dyslexia. As most sex differences in the brain are a result of early steroid hormone exposure, it is possible that sex ..
  24. Neural mechanisms of perceptual learning in the human brain
    Michael A Silver; Fiscal Year: 2011
    ..In addition, training procedures involving perceptual learning have been used to treat learning disorders like dyslexia and developmental disorders such as amblyopia...
  25. Interaction of Visual and Oculomotor Signals in Cortex
    Tirin Moore; Fiscal Year: 2013
    ..Key examples of such disorders include attention-deficit hyperactivity disorder (ADHD) and dyslexia, both of which appear to include deficits in oculomotor control...
  26. Visual psychophysics of human face processing
    Ken Nakayama; Fiscal Year: 2012
    ..estimates indicate that it could affect 2% of the population, a prevalence comparable to amblyopia and dyslexia. Yet, there has been little or no systematic research to understand this common, seriously disabling visual ..
  27. Signal Transfer in the Tectothalamic Pathway
    Martha E Bickford; Fiscal Year: 2011
    ..proposed studies should provide information relevant to the treatment of disorders of motion processing such as dyslexia, schizophrenia, autism and Williams Syndrome...
  28. Characterization of microRNAs expressed in the developing songbird brain
    Xiaoching Li; Fiscal Year: 2010
    ..g., autism, dyslexia, etc).
  29. Interaction of Visual and Oculomotor Signals in Cortex
    Tirin Moore; Fiscal Year: 2009
    ..Key examples of such disorders include attention-deficit hyperactivity disorder (ADHD) and dyslexia, both of which appear to include deficits in oculomotor control...
  30. Organization and Function of Mouse Visual Cortical Areas
    Edward M Callaway; Fiscal Year: 2013
    ..There is also evidence that some forms of dyslexia result from central visual system abnormalities...
  31. Mosaic Xlr3 Gene Expression in the Female Embryonic Mouse Brain
    Robert F Hevner; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Boys and girls show differential susceptibility to diseases such as dyslexia, autism and attention deficit hyperactivity disorder, in part due to differences in brain development...
  32. IONIC CURRENTS AND SPIKING IN CEREBELLAR NUCLEAR NEURONS
    Indira M Raman; Fiscal Year: 2012
    ..muscle movements, and whose electrical and chemical signaling patterns are disrupted in ataxia, dystonia, dyslexia, and autism...
  33. Improving the quality of visual developmental EEG data with eye tracking
    Mandy J Maguire; Fiscal Year: 2010
    ..increased our understanding of the neuronal processes underlying a variety of developmental disorders, such as dyslexia and ADHD, as well as perceptual and cognitive abilities in healthy adults for decades;however, these studies are ..
  34. Multisensory integration of faces and voices in the primate temporal lobe
    ASIF GHAZANFAR; Fiscal Year: 2013
    ..Second, a recent theory of dyslexia suggests that dyslexics are impaired at linking phonological sounds with vision...
  35. 2011 Cerebellum Gordon Research Conference
    Kamran Khodakhah; Fiscal Year: 2011
    ..manifest as ataxia and dyskinesia and it has also been implicated in cognitive disorders such as autism and dyslexia. The purpose of the Cerebellum Gordon Research Conference (GRC) is to foster an active dialogue between the very ..
  36. Prefrontal -> Top Down Contribution to Object Recognition
    Moshe Bar; Fiscal Year: 2010
    ..For example, magnocellular pathway abnormalities have been associated with visual deficits in schizophrenia and dyslexia. In addition the proposed examination of the cortical visual pathways will enhance our understanding of visual ..
  37. Neural Encoding and Connectivity in human speech perception
    BRIAN PASLEY; Fiscal Year: 2013
    ..function is a fundamental challenge for clinical insights into communication disorders such as aphasia or dyslexia. Better understanding of the neural basis of speech may also lead to development of neural prosthetic devices for ..
  38. The Brain Morphology of Children with Cleft Lip and/or Palate
    MADELEINE BLAIR CHOLLET; Fiscal Year: 2010
    ..with CL/P may also suffer from mild cognitive deficits and reading disabilities that are similar to developmental dyslexia. Recent neuroanatomical studies in individuals with CL/P indicate that these cognitive deficits may be associated ..
  39. Cortical Mechanisms of Visual Category Recognition and learning
    DAVID JORDAN FREEDMAN; Fiscal Year: 2013
    ..have relevance for understanding and addressing learning disabilities, such as attention deficit disorder and dyslexia, which affect a substantial fraction of school age children and young adults...
  40. Neural Mechanisms Underlying Complex Sound Recognition
    HELEN MARGUERITE MCLENDON; Fiscal Year: 2011
    ..HEALTH RELEVANCE: Hearing dysfunction is implicated in many disabilities including specific language impairments, dyslexia, and autism...
  41. Multi functional studies of candidate dyslexia susceptibility genes in the rat
    ALBERT MARK GALABURDA; Fiscal Year: 2013
    ..of developmental neurobiology, structural anatomy, and behavior to analyze the functions of three candidate dyslexia susceptibility genes (CDSGs)...
  42. Development of Neuronal Circuits in the Auditory Systems
    Karl Kandler; Fiscal Year: 2013
    ..biological and developmental basis of human auditory processing deficits, including deficits in speech perception or developmental dyslexia, that are associated with abnormal auditory processing on the level of the auditory brainstem.
  43. EEG synchrony of preterm infants: Regional disparities and perinatal risks
    Philip Grieve; Fiscal Year: 2009
    ..for cerebral palsy (CP), developmental delay, and sensory-motor deficits in infancy and learning disabilities, dyslexia, and hyperactivity-inattention syndromes at school age...
  44. Learning-dependent plasticity and mnemonic encoding in parieto-frontal networks
    Arup Sarma; Fiscal Year: 2013
    ..and Alzheimer's disease, work on conditions that affect learning such as Attention Deficit Disorder and Dyslexia could benefit from a more detailed understanding of the brain mechanisms underlying learning and memory...
  45. Brainstem enhancement of stimulus regularities with auditory expertise
    Dana L Strait; Fiscal Year: 2011
    ..for children with noise-exclusion deficits, including children with clinical disorders such as developmental dyslexia, specific language impairment and auditory processing disorders...
  46. Enegetics of neuronal populations by fMRI
    DEWAN SYED FAHMEED HYDER; Fiscal Year: 2013
    ..g., aging, autism, dyslexia)...
  47. Longitudinal Study of childhood dyslexia fMRI markers prior to reading onset
    Nadine Gaab; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Developmental dyslexia (DD) is one of the most prominent specific learning disabilities, affecting 5-17% of children...
  48. Cellular and Molecular Mechanisms of Early Cortical Development
    ERIC CHRISTOPHER OLSON; Fiscal Year: 2013
    ..are increasingly appreciated as an underlying cause of certain forms of epilepsy, mental retardation, autism, dyslexia and reading disorders...
  49. Development of Multisensory Cortex: Role of Experience
    MARK THOMAS WALLACE; Fiscal Year: 2012
    ..g., attention deficit hyperactivity disorder, autism spectrum disorder, developmental dyslexia) may have preferential deficits in multisensory processing, and that both diagnostic and remediation strategies ..
  50. Neocortical Mechanisms of Categorical Speech Perception
    Edward Chang; Fiscal Year: 2009
    ..g. aphasia, dyslexia, autism, et alia)...
  51. The Necessity of Norepinephrine for Auditory Cortical Plasticity
    KATHRYN NANCY SHEPARD; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Onset or treatment of audiological disorders such as dyslexia and tinnitus are associated with changes in neural activity in auditory cortex...
  52. Spectral and Temporal Integration in the Auditory System
    Mitchell L Sutter; Fiscal Year: 2013
    ..have relevance for the spectrum disorders (that include, but are not limited to attention deficit disorder, dyslexia, etc)...
  53. ATTENTIONAL PROCESSING OF TEMPORAL INFORMATION
    Catalin V Buhusi; Fiscal Year: 2013
    ..processes are impaired in patients with Parkinson's disease, Huntington's disease, Schizophrenia and Dyslexia. By studying the impact of attentional factors on cognitive mechanisms that require temporal processing, the ..
  54. Pleiotropic Roles of Dyslexia Genes in Neurodevelopmental Language Impairments
    JOHN EICHER; Fiscal Year: 2013
    ..Several behavioral disorders contain language impairment as a diagnostic basis, including dyslexia, Speech Sound Disorder (SSD), Specific Language Impairment (SLI), and Autism Spectrum Disorders (ASD)...
  55. Developmental Cognitive Neuroscience
    John Gabrieli; Fiscal Year: 2013
    ..integrating their work on normal development with parallel studies of developmental disorders, including autism, dyslexia, and specific language impairment...
  56. FRONTOTEMPORAL DEMENTIA: GENES, IMAGES, AND EMOTIONS
    Bruce L Miller; Fiscal Year: 2013
    ..the tasks used in the PPG offer a new way to probe conditions with anatomy that overlaps with FTD, including autism, attention deficit disorder, schizophrenia, bipolar illness, obsessive-compulsive disorder and dyslexia.
  57. Changes in the reading network of dyslexia as measured by multimodal imaging
    Kristi A Clark; Fiscal Year: 2012
    ..as an independent researcher in the field of developmental neuroscience, particularly with regard to the study of dyslexia. The candidate is currently a postdoctoral fellow with considerable research experience in functional and ..
  58. NIH PATHWAY TO INDEPENDENCE AWARD (PARENT K99/ROO)
    Kristi A Clark; Fiscal Year: 2013
    ..as an independent researcher in the field of developmental neuroscience, particularly with regard to the study of dyslexia. The candidate is currently a postdoctoral fellow with considerable research experience in functional and ..
  59. Connecting developmental mechanisms to visual function and perception
    CRISTOPHER NIELL; Fiscal Year: 2012
    ..principles of cortical development, our approach should be broadly applicable to a number of developmental disorders, such as dyslexia, autism, and schizophrenia, which are thought to result from aberrant cortical wiring and function.
  60. Neural systems for word recognition in space and time
    William W Graves; Fiscal Year: 2011
    ..neural system is critical for understanding reading acquisition and developmental language disorders such as dyslexia, for which deficits in orthographic, phonological, and semantic processing can arise in various parts of the ..
  61. Cortical mechanisms in speech perception: MEG studies
    DAVID E POEPPEL; Fiscal Year: 2012
    ..Health-related phenomena ranging from dyslexia and autism in childhood to aphasia and Alzheimer's disease in the aging population have been repeatedly ..
  62. CRCNS: Attentional Selection and Perceptional Organization
    Ernst Niebur; Fiscal Year: 2012
    ..The insight gained from this project will contribute to the understanding of the neural basis of cognitive disorders such as dyslexia and hemi-neglect.
  63. Functional organization of the superior temporal gyrus for speech perception
    Edward Chang; Fiscal Year: 2013
    ..of acquired and developmental language disabilities, including aphasia, language learning delay, autism, and dyslexia. Revealing mechanisms by which the brain encodes speech sounds bears tremendous implications for our ..
  64. A preschool biomarker for literacy
    Nina Kraus; Fiscal Year: 2013
    ..applicant): As many as one in ten children have the poor reading and spelling skills that comprise developmental dyslexia. It is widely accepted that there is a neurological basis;however, the nature of that basis is hotly debated...
  65. Are Frontal Lobe Size and Executive Dysfunction Contributors to ADHD AND Dyslexia
    Michelle Y Kibby; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Children with dyslexia frequently present with poor phonological processing...
  66. NEUROPSYCHOLOGICAL MODEL OF DEVELOPMENTAL AGRAPHIA
    David Roeltgen; Fiscal Year: 1990
    ..regarding the efficient and accurate use of phonologic ability and its breakdown as the hallmark of developmental dyslexia and dysgraphia...
  67. FMRI of Phonemic Perception in Children with Developmental Dyslexia
    Lisa Conant; Fiscal Year: 2009
    Developmental dyslexia is a language-based learning disability primarily characterized by difficulties decoding and recognizing printed words accurately and/or fluently...
  68. LOCALIZATION OF A GENE UNDERLYING CEREBRAL LATERALITY
    Daniel Geschwind; Fiscal Year: 1999
    ..work to the development of cognitive abilities is emphasized by the association of handedness with a subtype of dyslexia in the group of families that we propose to study...
  69. BRAIN-BEHAVIOR RELATIONS IN SCHIZOPHRENIA: IMPACT OF SEX
    Jill Goldstein; Fiscal Year: 1993
    ..some of the processes underlying gender differences in abnormal neurodevelopment in schizophrenia, by using dyslexia as a model...
  70. Cholinergic Enhancement of Human Cortical Plasticity
    Bruce Rosen; Fiscal Year: 2003
    ..of several different neurological conditions, such as stroke-induced movement disorders, dystonia, and dyslexia. However, extremely intensive training has been required, and has yielded results that, although promising, fall ..
  71. Optogenetic analysis of circuits for vocal recognition
    Richard Mooney; Fiscal Year: 2009
    ..the broad array of pathologies that affect speech comprehension, such as aphasic stroke, autism and developmental dyslexia. Most of these conditions involve damage or dysfunction in the auditory cortex, indicating that this structure ..
  72. GENOTYPE AND PHENOTYPE ANALYSES OF FAMILIAL DYSLEXIA
    Bruce Pennington; Fiscal Year: 1993
    ..research are to achieve a better understanding of both the genetics and the phenotype(s) of developmental dyslexia. Genetic heterogeneity appears to be very likely in dyslexia, but key features of the linguistic phenotype appear ..
  73. DIAGNOSIS AND TREATMENT OF READING DEFICITS IN APHASIA
    Margaret Greenwald; Fiscal Year: 2001
    Reading deficits are very common and persistent following stroke in previously literate adults. Acquired dyslexia occurs in patients with and without other language deficits, but these patients rarely receive dyslexia treatment...
  74. Molecular genetics of executive function in dyslexia
    Zoran Brkanac; Fiscal Year: 2009
    ..Dr. Raskind is part of an established multidisciplinary research team investigating dyslexia. This study proposes to investigate the genetic basis for dyslexia...