learning disorders

Summary

Summary: Conditions characterized by a significant discrepancy between an individual's perceived level of intellect and their ability to acquire new language and other cognitive skills. These disorders may result from organic or psychological conditions. Relatively common subtypes include DYSLEXIA, dyscalculia, and dysgraphia.

Top Publications

  1. ncbi Dyslexia and dyscalculia: two learning disorders with different cognitive profiles
    Karin Landerl
    Department of Psychology, University of Tuebingen, Tuebingen, Germany
    J Exp Child Psychol 103:309-24. 2009
  2. ncbi Genetic influences on early word recognition abilities and disabilities: a study of 7-year-old twins
    Nicole Harlaar
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    J Child Psychol Psychiatry 46:373-84. 2005
  3. ncbi Generalist genes and learning disabilities
    Robert Plomin
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Psychol Bull 131:592-617. 2005
  4. ncbi Maternal thyroid hormones early in pregnancy and fetal brain development
    Gabriella Morreale de Escobar
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas CSIC y Universidad Autonoma de Madrid UAM, Arturo Duperier, 4, 28029 Madrid, Spain
    Best Pract Res Clin Endocrinol Metab 18:225-48. 2004
  5. ncbi Developmental dyscalculia
    Ruth S Shalev
    Neuropediatric Unit, Shaare Zedek Medical Center, Jerusalem, Israel
    J Child Neurol 19:765-71. 2004
  6. ncbi Very preterm children show impairments across multiple neurodevelopmental domains by age 4 years
    L J Woodward
    Canterbury Child Development Research Group, Department of Psychology, University of Canterbury, Christchurch, New Zealand
    Arch Dis Child Fetal Neonatal Ed 94:F339-44. 2009
  7. ncbi Dyslexics are impaired on implicit higher-order sequence learning, but not on implicit spatial context learning
    James H Howard
    Department of Psychology, The Catholic University of America, Washington, DC 20064, USA
    Neuropsychologia 44:1131-44. 2006
  8. ncbi Mathematics and learning disabilities
    David C Geary
    Department of Psychological Sciences, University of Missouri Columbia, 65211 2500, USA
    J Learn Disabil 37:4-15. 2004
  9. ncbi Obesity interventions for people with a learning disability: an integrative literature review
    Annette Jinks
    Evidence based Practice Research Centre, Faculty of Health, Edge Hill University, UK
    J Adv Nurs 67:460-71. 2011
  10. pmc Aberrant functional activation in school age children at-risk for mathematical disability: a functional imaging study of simple arithmetic skill
    Nicole Davis
    Vanderbilt University Kennedy Center for Research on Human Development, USA
    Neuropsychologia 47:2470-9. 2009

Detail Information

Publications260 found, 100 shown here

  1. ncbi Dyslexia and dyscalculia: two learning disorders with different cognitive profiles
    Karin Landerl
    Department of Psychology, University of Tuebingen, Tuebingen, Germany
    J Exp Child Psychol 103:309-24. 2009
    ..in the comorbid dyslexia/dyscalculia group were additive; that is, they resulted from the combination of two learning disorders. These findings suggest that dyslexia and dyscalculia have separable cognitive profiles, namely a ..
  2. ncbi Genetic influences on early word recognition abilities and disabilities: a study of 7-year-old twins
    Nicole Harlaar
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    J Child Psychol Psychiatry 46:373-84. 2005
    ..A fundamental issue for child psychology concerns the origins of individual differences in early reading development...
  3. ncbi Generalist genes and learning disabilities
    Robert Plomin
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Psychol Bull 131:592-617. 2005
    ..Third, genes that affect one learning disability are also likely to affect other learning disabilities. These quantitative genetic findings have far-reaching implications for molecular genetics and neuroscience as well as psychology...
  4. ncbi Maternal thyroid hormones early in pregnancy and fetal brain development
    Gabriella Morreale de Escobar
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas CSIC y Universidad Autonoma de Madrid UAM, Arturo Duperier, 4, 28029 Madrid, Spain
    Best Pract Res Clin Endocrinol Metab 18:225-48. 2004
    ..Detection of an inappropiate first trimester FT4 surge that may not result in increased TSH, may be crucial for the prevention of learning disabilities in a significant number of unborn children...
  5. ncbi Developmental dyscalculia
    Ruth S Shalev
    Neuropediatric Unit, Shaare Zedek Medical Center, Jerusalem, Israel
    J Child Neurol 19:765-71. 2004
    ..The long-term prognosis of dyscalculia and the role of remediation in its outcome are yet to be determined...
  6. ncbi Very preterm children show impairments across multiple neurodevelopmental domains by age 4 years
    L J Woodward
    Canterbury Child Development Research Group, Department of Psychology, University of Canterbury, Christchurch, New Zealand
    Arch Dis Child Fetal Neonatal Ed 94:F339-44. 2009
    ..Of particular interest were children's risks of impairment across multiple neurodevelopmental domains...
  7. ncbi Dyslexics are impaired on implicit higher-order sequence learning, but not on implicit spatial context learning
    James H Howard
    Department of Psychology, The Catholic University of America, Washington, DC 20064, USA
    Neuropsychologia 44:1131-44. 2006
    ..The specific nature of their learning deficit is consistent with reports of physiological and anatomical differences for individuals with dyslexia in frontal and cerebellar structures...
  8. ncbi Mathematics and learning disabilities
    David C Geary
    Department of Psychological Sciences, University of Missouri Columbia, 65211 2500, USA
    J Learn Disabil 37:4-15. 2004
    ..The deficits are discussed in terms of three subtypes of mathematics learning disability and in terms of a more general framework for linking research in mathematical cognition to research in learning disabilities...
  9. ncbi Obesity interventions for people with a learning disability: an integrative literature review
    Annette Jinks
    Evidence based Practice Research Centre, Faculty of Health, Edge Hill University, UK
    J Adv Nurs 67:460-71. 2011
    ....
  10. pmc Aberrant functional activation in school age children at-risk for mathematical disability: a functional imaging study of simple arithmetic skill
    Nicole Davis
    Vanderbilt University Kennedy Center for Research on Human Development, USA
    Neuropsychologia 47:2470-9. 2009
    ....
  11. ncbi Comorbidity of learning disorders: prevalence and familial transmission
    Karin Landerl
    University of Tuebingen, 72072 Tuebingen, Germany
    J Child Psychol Psychiatry 51:287-94. 2010
    ..So far, empirical evidence on comorbidities of specific learning disorders in arithmetic, reading and spelling is scarce.
  12. ncbi Implicit motor learning deficits in dyslexic adults
    Catherine J Stoodley
    Department of Physiology, University of Oxford, Parks Road, Oxford OX1 3PT, UK
    Neuropsychologia 44:795-8. 2006
    ..015). This suggests that some dyslexics may suffer from an implicit motor learning deficit, which could generalize to non-motor learning...
  13. ncbi Dyslexic children show deficits in implicit sequence learning, but not in explicit sequence learning or contextual cueing
    Gracia Jiménez-Fernández
    Departamento de Psicologia Evolutiva y de la Educacion, Universidad de Granada, Granada, Spain
    Ann Dyslexia 61:85-110. 2011
    ..These results help to clarify previous contradictory data, and they are discussed in relation to how the implicit sequence learning deficit could contribute to the understanding of dyslexia...
  14. ncbi Learning difficulties in schoolchildren born with very low birth weight
    Maura C C de Rodrigues
    Instituto Fernandes Figueira FIOCRUZ, Hospital Municipal Raphael de Paula Souza, Secretaria Municipal da Saúde, Rio de Janeiro, RJ, Brazil
    J Pediatr (Rio J) 82:6-14. 2006
    ....
  15. ncbi Implicit learning deficit in children with developmental dyslexia
    Stefano Vicari
    Servizio di Neurologia e Riabilitazione, IRCCS, Children s Hospital Bambino Gesu, Lungomare Guglielmo Marconi 36, I 00058, Santa Marinella, Rome, Italy
    Neuropsychologia 41:108-14. 2003
    ....
  16. ncbi The role of sensorimotor impairments in dyslexia: a multiple case study of dyslexic children
    Sarah White
    Institute of Cognitive Neuroscience, University College London, UK
    Dev Sci 9:237-55; discussion 265-9. 2006
    ..Visual stress seems to account for a small proportion of dyslexics, independently of the commonly reported phonological deficit. However, there is little evidence for a causal role of auditory, motor or other visual impairments...
  17. pmc Moving, sensing and learning with cerebellar damage
    Amy J Bastian
    Kennedy Krieger Institute, Department of Neuroscience, The Johns Hopkins School of Medicine, United States
    Curr Opin Neurobiol 21:596-601. 2011
    ..This review covers these and other recent advances, focusing on how cerebellar damage affects human abilities ranging from sensory perception to movement control and motor learning...
  18. ncbi A review of association and linkage studies for genetical analyses of learning disorders
    Emrah Caylak
    Department of Biochemistry and Clinical Biochemistry, Firat University, School of Medicine, Elazig, Turkey
    Am J Med Genet B Neuropsychiatr Genet 144:923-43. 2007
    b>Learning disorders (LD) commonly comprise of a heterogeneous group of disorders manifested by unexpected problems in some children's experiences in the academic performance arena...
  19. ncbi Pseudoname learning by German-speaking children with dyslexia: evidence for a phonological learning deficit
    H Mayringer
    University of Salzburg, Salzburg, Austria
    J Exp Child Psychol 75:116-33. 2000
    ....
  20. ncbi Is implicit sequence learning impaired in Parkinson's disease? A meta-analysis
    Richard J Siegert
    Department of Medicine, Wellington School of Medicine and Health Sciences, University of Otago, Wellington South, New Zealand
    Neuropsychology 20:490-5. 2006
    ..73 (95% confidence interval = 0.38, 1.07). Implicit sequence learning appears to be impaired in patients with PD. Some common methodological weaknesses and limitations in the reporting of statistical data are discussed...
  21. ncbi Is implicit sequence learning impaired in schizophrenia? A meta-analysis
    Richard J Siegert
    King s College London, Department of Palliative Care, Policy and Rehabilitation, School of Medicine at Guy s, King s College and St Thomas Hospitals, Weston Education Centre, Denmark Hill, London, UK
    Brain Cogn 67:351-9. 2008
    ..Suggestions for improving the methodological quality and statistical reporting of studies of this topic are made...
  22. ncbi Dysfunctional neural network of spatial working memory contributes to developmental dyscalculia
    S Rotzer
    MR Center, University Children s Hospital, Steinwiesstrasse 75, CH 8032 Zurich, Switzerland
    Neuropsychologia 47:2859-65. 2009
    ..These poor spatial working memory processes may inhibit the formation of spatial number representations (mental numberline) as well as the storage and retrieval of arithmetical facts...
  23. ncbi Different underlying neurocognitive deficits in developmental dyslexia: a comparative study
    D Menghini
    Neuroscience Department, Children s Hospital Bambino Gesu, Research Hospital, Rome, Italy
    Neuropsychologia 48:863-72. 2010
    ....
  24. pmc A genome-wide association study identifies multiple loci associated with mathematics ability and disability
    S J Docherty
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Genes Brain Behav 9:234-47. 2010
    ....
  25. ncbi A combined event-related potential and neuropsychological investigation of developmental dyscalculia
    Fruzsina Soltész
    Centre for Neuroscience in Education, Faculty of Education, University of Cambridge, UK
    Neurosci Lett 417:181-6. 2007
    ..Further, DD subjects did not differ from controls in general mental rotation and in body parts knowledge, but were markedly impaired in mental finger rotation, finger knowledge, and tactile performance...
  26. ncbi Cerebellar disorders in childhood: cognitive problems
    Maja Steinlin
    Neuropaediatrics, University Children s Hospital, Inselspital, Bern, Switzerland
    Cerebellum 7:607-10. 2008
    ..In conclusion, the cerebellum seems to play an important role in many higher cognitive functions, especially in learning. There is a suggestion that the earlier the incorrect influence, the more pronounced the problems...
  27. pmc Social withdrawal in childhood
    Kenneth H Rubin
    Department of Human Development, University of Maryland, College Park, Maryland 20742 1131, USA
    Annu Rev Psychol 60:141-71. 2009
    ....
  28. ncbi Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome
    H M Lachman
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am J Med Genet 67:468-72. 1996
    ..We now report that in a population of patients with VCFS, there is an apparent association between the low-activity allele, COMT158met, and the development of bipolar spectrum disorder, and in particular, a rapid-cycling form...
  29. pmc Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice
    Miguel Verbitsky
    Columbia Genome Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Learn Mem 11:253-60. 2004
    ..Those changes could be involved in the memory deficits we observed in the 15-month-old mice. In agreement with previous reports, we also found altered expression in genes related to inflammation, protein processing, and oxidative stress...
  30. ncbi The human cerebellum and associative learning: dissociation between the acquisition, retention and extinction of conditioned eyeblinks
    V Bracha
    Division of Neurobiology, Barrow Neurological Institute, 350 W Thomas Rd, Phoenix, AZ, USA
    Brain Res 860:87-94. 2000
    ..This finding suggests that in humans, the acquisition of new and the extinction of previously learned conditioned responses depends on a similar set of cerebellar circuits...
  31. ncbi Obesity and disability - a short review
    L J Ells
    School of Health and Social Care, University of Teesside, Middlesbrough, UK
    Obes Rev 7:341-5. 2006
    ..Future research efforts are required to strengthen the evidence base examining obesity in back disorders, mental health and learning disabilities, in order to improve current clinical management...
  32. pmc Learning disabilities and intellectual functioning in school-aged children with prenatal cocaine exposure
    Connie E Morrow
    Department of Pediatrics, University of Miami School of Medicine, Miami, FL 33101, USA
    Dev Neuropsychol 30:905-31. 2006
    ....
  33. ncbi [German version of the math anxiety questionnaire (FRA) for 6- to 9-year-old children]
    Helga Krinzinger
    Lehr und Forschungsgebiet Neuropsychologie, Neurologische Klinik, Universitätsklinikum der RWTH Aachen, Deutschland
    Z Kinder Jugendpsychiatr Psychother 35:341-51. 2007
    ..Is the FRA a reliable and valid instrument? Are there any gender differences concerning math anxiety? Are there any developmental changes in this regard in the course of the early grades?..
  34. ncbi The implicit sequence learning deficit in patients with Parkinson's disease: a matter of impaired sequence integration?
    Jared G Smith
    School of Psychology, Victoria University of Wellington, PO Box 600, Wellington, New Zealand
    Neuropsychologia 44:275-88. 2006
    ..The implicit learning deficits of PD patients are discussed with regard to the role played by the basal ganglia in integrative sequence learning in the SRT...
  35. ncbi The relationship between gross motor skills and academic achievement in children with learning disabilities
    Marieke Westendorp
    Centre for Human Movement Sciences, University Medical Centre Groningen, University of Groningen, Section F, PO Box 196, 9700 AD Groningen, The Netherlands
    Res Dev Disabil 32:2773-9. 2011
    ..This study stresses the importance of specific interventions facilitating both motor and academic abilities...
  36. pmc An unliganded thyroid hormone receptor causes severe neurological dysfunction
    K Hashimoto
    Section of Endocrinology and Metabolism, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 98:3998-4003. 2001
    ..These findings demonstrate the specific and deleterious action of unliganded TR in the brain and suggest the importance of corepressors bound to TR in the pathogenesis of hypothyroidism...
  37. ncbi Low birth weight, prematurity, and paternal social status: impact on the basic competence test in Taiwanese adolescents
    Wen Li Wang
    Research Center for Psychological and Educational Testing, National Taiwan Normal University, Taipei, Taiwan
    J Pediatr 153:333-8. 2008
    ..To investigate whether birth weight and paternal education may have independent and interactive effects on the learning achievement of adolescents...
  38. ncbi Interference control in working memory: comparing groups of children with atypical development
    Paola Palladino
    Department of Psychology, University of Pavia, Italy
    Child Neuropsychol 19:37-54. 2013
    ..In turn, these findings strengthen and clarify the role of interference control, one of the most critical prefrontal functions, in working memory...
  39. ncbi Mathematical thinking in second-grade children with different forms of LD
    N C Jordan
    University of Delaware, School of Education, Newark 19716, USA
    J Learn Disabil 33:567-78. 2000
    ....
  40. ncbi Do children with developmental dyslexia have impairments in implicit learning?
    Elpis V Pavlidou
    Moray House School of Education, University of Edinburgh, St John s Land, Edinburgh, UK
    Dyslexia 16:143-61. 2010
    ..e. grammaticality or chunk strength). We propose that children with developmental dyslexia may be impaired in their implicit rule abstraction mechanism, which can partially explain their persistent reading problems...
  41. ncbi Working memory deficits in children with specific learning disorders
    Kirsten Schuchardt
    University of Gottingen, Germany
    J Learn Disabil 41:514-23. 2008
    ..Although children with both reading and arithmetic disorders are consistently outperformed by all other groups, there is no significant interaction between the factors dyscalculia and dyslexia...
  42. ncbi Polyunsaturated fatty acids (PUFAs) for children with specific learning disorders
    May Loong Tan
    Department of Paediatrics, Penang Medical College, Penang, Malaysia
    Cochrane Database Syst Rev 12:CD009398. 2012
    ..Some children with specific learning disorders have been found to be deficient in these PUFAs, and it is argued that supplementation of PUFAs may help ..
  43. ncbi Hidden language impairments in children: parallels between poor reading comprehension and specific language impairment?
    Kate Nation
    Department of Experimental Psychology, University of Oxford, Oxford, U K
    J Speech Lang Hear Res 47:199-211. 2004
    ..These findings demonstrate that serious reading and language impairments are not always obvious in children who have good phonological ability and appear, superficially at least, to read well...
  44. ncbi Calculation difficulties in children of very low birthweight: a neural correlate
    E B Isaacs
    MRC Childhood Nutrition Research Centre and Radiology and Physics Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Brain 124:1701-7. 2001
    ..To our knowledge, this is the first report establishing a structural neural correlate of calculation ability in a group of neurologically normal individuals...
  45. ncbi The use of tinted lenses and colored overlays for the treatment of dyslexia and other related reading and learning disorders
    Gary J Williams
    AOA Binocular Vision Working Group, USA
    Optometry 75:720-2. 2004
  46. ncbi Obesity in people with intellectual disabilities: the impact of nurse-led health screenings and health promotion activities
    David Marshall
    Down Lisburn Health and Social Services Trust, Disability Resource Centre, Downpatrick, UK
    J Adv Nurs 41:147-53. 2003
    ..Obesity appears to be more common among people with intellectual disabilities, with few studies focusing on achieving weight reduction...
  47. ncbi Children with a learning disorder show prospective control impairments during visuomanual tracking
    Dominique van Roon
    Research Center for Movement Control and Neuroplasticity, Department of Biomedical Kinesiology, Katholieke Universiteit Leuven, Heverlee, Belgium
    Res Dev Disabil 31:195-202. 2010
    ..Furthermore, children with LD did not improve from the 1st to the 2nd trial, possibly as a result of slower visuomotor adaptation processes...
  48. pmc Learning problems in kindergarten students with extremely preterm birth
    H Gerry Taylor
    Department of Pediatrics, Case Western Reserve University, Rainbow Babies and Children s Hospital, University Hospitals Case Medical Center, Cleveland, OH 44106 6038, USA
    Arch Pediatr Adolesc Med 165:819-25. 2011
    ..To assess learning problems among kindergarten students with extremely preterm birth and to identify risk factors...
  49. ncbi Assessing fears and related anxieties in children and adolescents with learning disabilities or mild mental retardation
    Huijun Li
    Department of Educational Psychology and Learning Systems, Florida State University, 307 Stone Building, College of Education, Tallahassee, FL 32306 4453, USA
    Res Dev Disabil 28:445-57. 2007
    ..Age main effects were also observed where younger students from both the LD and the MIMR groups reported higher levels of non-specific general anxiety. Implications and directions for future research were presented...
  50. ncbi Cognitive arithmetic and problem solving: a comparison of children with specific and general mathematics difficulties
    N C Jordan
    Department of Educational Studies, University of Delaware, Newark 19716, USA
    J Learn Disabil 30:624-34, 684. 1997
    ....
  51. pmc Women with learning disabilities and access to cervical screening: retrospective cohort study using case control methods
    Fiona Reynolds
    Clinical Epidemiology and Public Health Unit, University of Manchester, Manchester, UK
    BMC Public Health 8:30. 2008
    ..It was carried out in Bury, Heywood-and-Middleton and Rochdale...
  52. ncbi Mathematical problems in children with developmental coordination disorder
    Stefanie Pieters
    Department of Experimental Clinical and Health Psychology, Ghent University, Belgium
    Res Dev Disabil 33:1128-35. 2012
    ..No evidence for a mathematical deficit was found. Diagnostic implications are discussed...
  53. ncbi Intracerebroventricular injection of streptozotocin in rats produces both oxidative stress in the brain and cognitive impairment
    M Sharma
    Department of Pharmacology, All India Institute of Medical Sciences, New Delhi
    Life Sci 68:1021-9. 2001
    ..The study demonstrates that intracerebroventricular STZ may be appropriate model for investigations of antioxidants as potential treatment in Alzheimer's dementia...
  54. ncbi Melatonin prevents learning disorders in brain-lesioned newborn mice
    M Bouslama
    INSERM, U676, Robert Debre Hospital, 48 Bvd Serurier, 75019 Paris, France
    Neuroscience 150:712-9. 2007
    ..Thus, melatonin, which easily crosses the blood-brain barrier and has been proven safe in children, may be effective in preventing learning disabilities caused by perinatal brain injuries in human preterm infants...
  55. ncbi ADHD and dyscalculia: Evidence for independent familial transmission
    Michael C Monuteaux
    Massachusetts General Hospital, Pediatric Psychopharmacology Program, Boston, 02114, USA
    J Learn Disabil 38:86-93. 2005
    ..These results reinforce the current nosological approach to these disorders and underscore the need for separate identification and treatment strategies for children with both conditions...
  56. ncbi Language-based cognitive functioning in parents of offspring with ADHD comorbid for Tourette syndrome or learning disabilities
    M B Casey
    Department of Counseling and Developmental Psychology, Boston College, Chestnut Hill, MA 02192, USA
    Dev Neuropsychol 17:85-110. 2000
    ....
  57. ncbi Learning disorders
    William G Kronenberger
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA
    Neurol Clin 21:941-52. 2003
    ..Although it is rare for individuals to completely outgrow the academic weaknesses characteristic of an LD, their performance in the area of weakness often can be improved markedly with appropriate interventions...
  58. pmc Clinical utility of the Vanderbilt ADHD Rating Scale for ruling out comorbid learning disorders
    Joshua M Langberg
    Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Pediatrics 126:e1033-8. 2010
    ..The goal was to examine the clinical utility of using the Vanderbilt Attention-Deficit/Hyperactivity Disorder (ADHD) Rating Scale (VARS) to determine when to refer children with ADHD for learning disorder (LD) evaluations...
  59. pmc Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin
    Vanessa Coremans
    KU Leuven, VIB Vesalius Research Center, Herestraat 49, Gasthuisberg O and N1, B3000 Leuven, Belgium
    BMC Neurosci 11:2. 2010
    ..Survivin is highly expressed in neural precursor cells in the brain, yet its function there has not been elucidated...
  60. ncbi Cholinesterase inhibitors ameliorate spatial learning deficits in rats following hypobaric hypoxia
    Sangu Muthuraju
    Neurobiology Division, Defence Institute of Physiology and Allied Sciences, Defence Research and Development Organization, Ministry of Defence, Government of India, Lucknow Road, Timarpur, Delhi, 110054, India
    Exp Brain Res 203:583-92. 2010
    ..The AChEIs were also able to restore the neuronal morphology. Our data suggest that cholinergic system is affected by HBH, and AChEIs were able to improve HBH-induced learning impairment in rats...
  61. ncbi A meta-analysis of blood fatty acids in people with learning disorders with particular interest in arachidonic acid
    N L Morse
    Efamol Ltd, 14 The Mole Business Park, Leatherhead, Surrey KT22 7BA, UK
    Prostaglandins Leukot Essent Fatty Acids 81:373-89. 2009
    Small individual studies report that people with learning disorders have lower than normal blood concentrations of docosahexaenoic acid and arachidonic acid...
  62. ncbi Gilles de la Tourette's syndrome in special education schools: a United Kingdom study
    V Eapen
    University College London Medical School, Department of Psychiatry, Middlesex Hospital, UK
    J Neurol 244:378-82. 1997
    ..In these children, the presence of tics may be an indicator of an underlying dysfunction of neurological development...
  63. ncbi Functional and structural alterations of the intraparietal sulcus in a developmental dyscalculia of genetic origin
    Nicolas Molko
    INSERM U 562, Cognitive Neuroimaging, Service Hospitalier Frederic Joliot, CEA DSV, IFR 49 Orsay, France
    Neuron 40:847-58. 2003
    ..Thus, a genetic form of developmental dyscalculia can be related to both functional and structural anomalies of the right intraparietal sulcus, suggesting a crucial role of this region in the development of arithmetic abilities...
  64. ncbi Learning disorders in children with epilepsy
    Evangelos Pavlou
    2nd Department of Pediatrics, Aristotle University of Thessaloniki, AHEPA General Hospital, Elaiones Pilaias, Thessaloniki 55535, Greece
    Childs Nerv Syst 27:373-9. 2011
    b>Learning Disorders (LD) are defined as disorders that interfere with academic performance or with daily activities that require reading, writing or mathematical skills in subjects with a normal intelligence quotient (IQ)...
  65. ncbi Predictors, costs and characteristics of out of area placement for people with intellectual disability and challenging behaviour
    D G Allen
    Bro Morgannwg NHS Trust, Cardiff, UK
    J Intellect Disabil Res 51:409-16. 2007
    ..Out of area placements for people with challenging behaviour represent an expensive and often ineffective strategy for meeting the needs of this service user group...
  66. ncbi Secondhand smoke exposure and neurobehavioral disorders among children in the United States
    Zubair Kabir
    Tobacco Free Research Institute, Dublin, Ireland
    Pediatrics 128:263-70. 2011
    ..Excess neurobehavioral disorders attributable to secondhand smoke (SHS) exposure in the home in 2007 were further investigated...
  67. ncbi Prevalence of overweight in children with developmental disorders in the continuous national health and nutrition examination survey (NHANES) 1999-2002
    Linda G Bandini
    University of Massachusetts Medical School, Eunice Kennedy Shriver Center, Waltham, Massachusetts, USA
    J Pediatr 146:738-43. 2005
    ..To estimate the prevalence of overweight in children identified with developmental disorders on the basis of nationally representative survey data...
  68. ncbi Procedural motor learning in Parkinson's disease
    H I Krebs
    Massachusetts Institute of Technology, Mechanical Engineering Department, Newman Laboratory for Biomechanics and Human Rehabilitation, 77 Massachusetts Avenue, Office 3 137, Cambridge, MA 02139, USA
    Exp Brain Res 141:425-37. 2001
    ..Better understanding of these deficits should facilitate the rehabilitation of PD patients...
  69. ncbi Prevalence of obesity among children with chronic conditions
    Alex Y Chen
    Children s Hospital Los Angeles, Department of Pediatrics, University of Southern California, Los Angeles, California, USA
    Obesity (Silver Spring) 18:210-3. 2010
    ..9% (18.7-19.0). Our findings suggest that children 10-17 years of age with select chronic conditions were at increased risk for obesity compared to their counterparts without a chronic condition...
  70. pmc Anesthesia for cesarean delivery and learning disabilities in a population-based birth cohort
    Juraj Sprung
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, USA
    Anesthesiology 111:302-10. 2009
    ..The association between perinatal exposure to anesthetics during Cesarean delivery (CD) and development of learning disabilities (LD) was determined in a population-based birth cohort...
  71. ncbi Procedural learning difficulties: reuniting the developmental disorders?
    Roderick I Nicolson
    Department of Psychology, University of Sheffield, Sheffield S10 2TP, UK
    Trends Neurosci 30:135-41. 2007
    ..This approach highlights the need for development of "neurocognitive" tests to probe the function of components of each neural system and improve strategies for explanation, diagnosis and support of developmental disorders...
  72. ncbi Motor phenotypic alterations in TgDyrk1a transgenic mice implicate DYRK1A in Down syndrome motor dysfunction
    M Martinez de Lagran
    Programme of Genes and Disease, Center for Genomic Regulation, 08003 Barcelona, Spain
    Neurobiol Dis 15:132-42. 2004
    ..These results confirm and extend previous data and provide further insight to the functional domains that might be altered in TgDyrk1a mice and underlying molecular mechanisms of DS motor dysfunction...
  73. ncbi Lesions of the Basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learning
    James M Conner
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 38:819-29. 2003
    ..These results support the hypothesis that the basal forebrain cholinergic system may be specifically implicated in forms of learning requiring plasticity of cortical representations...
  74. ncbi 22q11.2 deletion syndrome: DiGeorge, velocardiofacial, and conotruncal anomaly face syndromes
    B F Cuneo
    Heart Institute for Children, Department of Pediatrics, Hope Children s Hospital, University of Illinois at Chicago, Chicago, Illinois 60045, USA
    Curr Opin Pediatr 13:465-72. 2001
    ..The ubiquitin-fusion-degradation-1-like gene, expressed in embryonic branchial arches and in the conotruncus, appears to play a prominent role in the pathogenesis of the 22q11.2 deletion syndrome...
  75. pmc Illness in people with intellectual disabilities
    Afia Ali
    BMJ 336:570-1. 2008
  76. pmc Association of serum concentrations of persistent organic pollutants with the prevalence of learning disability and attention deficit disorder
    Duk Hee Lee
    Department of Preventive Medicine, School of Medicine, Kyungpook University, 101 Dongin dong, Jung Gu, Daegu 700 422, Korea
    J Epidemiol Community Health 61:591-6. 2007
    ....
  77. ncbi Dyslexia and the failure to form a perceptual anchor
    Merav Ahissar
    Department of Psychology, Hebrew University, Jerusalem 91904, Israel
    Nat Neurosci 9:1558-64. 2006
    ..This hypothesis provides a direct link between D-LDs' high-level difficulties and mechanisms at the level of specific neuronal circuits...
  78. ncbi Basic number processing deficits in ADHD: a broad examination of elementary and complex number processing skills in 9- to 12-year-old children with ADHD-C
    Liane Kaufmann
    Clinical Department of Pediatrics IV, Division Neuropedriatrics, Innsbruck Medical University, Innsbruck, Austria
    Dev Sci 11:692-9. 2008
    ..Thus, number processing skills and in particular the processing of numerical magnitude should be investigated in children diagnosed with ADHD even when no comorbid learning disabilities are reported...
  79. ncbi Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1
    Rui M Costa
    Departments of Neurobiology, Psychiatry and Psychology, BRI, University of California at Los Angeles, Los Angeles, California 90095 1761, USA
    Nature 415:526-30. 2002
    ..Our findings have implications for the development of treatments for learning deficits associated with NF1...
  80. ncbi Genetics and educational psychology
    Robert Plomin
    Institute of Psychiatry, King s College London, UK
    Br J Educ Psychol 73:3-14. 2003
    ..Molecular genetics, one of the most energetic and exciting areas of science, is slowly but surely coming to educational psychology...
  81. ncbi Secondary conditions in children with disabilities: spina bifida as a case example
    Rune J Simeonsson
    School of Education and Frank Porter Graham Child Development Institute, University of North Carolina at Chapel Hill 27599 3500, USA
    Ment Retard Dev Disabil Res Rev 8:198-205. 2002
    ..The significance of secondary conditions is that they are preventable. Identifying the mechanisms associated with their manifestation is thus an important priority for the development of effective prevention programs...
  82. pmc Mathematical ability of 10-year-old boys and girls: genetic and environmental etiology of typical and low performance
    Yulia Kovas
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK
    J Learn Disabil 40:554-67. 2007
    ..We conclude that low mathematical performance is the quantitative extreme of the same genetic and environmental factors responsible for variation throughout the distribution...
  83. ncbi Developmental dyscalculia: heterogeneity might not mean different mechanisms
    Orly Rubinsten
    Edmond J Safra Brain Research Center for the Study of Learning Disabilities, Department of Learning Disabilities, University of Haifa, Israel
    Trends Cogn Sci 13:92-9. 2009
    ..These proposed frameworks have the potential of facilitating future discussions, work in the field and have implications for studies of similar disorders like dyslexia and attention-deficit/hyperactivity disorder...
  84. ncbi Development and psychometric properties of the Glasgow Depression Scale for people with a Learning Disability. Individual and carer supplement versions
    Fiona M Cuthill
    University of Glasgow, Scotland, UK
    Br J Psychiatry 182:347-53. 2003
    ..There is no reliable and valid self-report measure of depressive symptoms for people with learning disabilities...
  85. ncbi Depression in people with intellectual disability: an evaluation of a staff-administered treatment program
    Jane A McGillivray
    School of Psychology, Deakin University, Burwood, Victoria 3125, Australia
    Res Dev Disabil 29:524-36. 2008
    ..The results indicate that staff can be trained to deliver a CBT program within community settings that is effective in the reduction of depression symptomatology in people with mild ID...
  86. ncbi Visual impairment in adult people with moderate, severe, and profound intellectual disability
    M Warburg
    Center for Disabled People, Glostrup Hospital, Glostrup, Denmark
    Acta Ophthalmol Scand 79:450-4. 2001
    ..To assess visual impairment in adults with intellectual disability after de-institutionalisation...
  87. ncbi Neuro-cognitive impairment following acquired central nervous system infections in childhood: a systematic review
    Julie A Carter
    Neurosciences Unit, Institute of Child Health, The Wolfson Centre, Mecklenburgh Square, WC1N 2AP, London, UK
    Brain Res Brain Res Rev 43:57-69. 2003
    ..Higher morbidity for similar mortality in acute bacterial meningitis compared with cerebral malaria in the epidemiological data may suggest future research directions for clinical research to devise more effective interventions...
  88. ncbi Impact of neurofibromatosis type 1 on school performance
    Lianne C Krab
    Department of General Pediatrics, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    J Child Neurol 23:1002-10. 2008
    ..Taken together, it was shown that neurofibromatosis type 1 has profound impact on school performance. Awareness of these problems may facilitate timely recognition and appropriate support...
  89. ncbi A community-based assessment of learning disabilities using environmental and contextual risk factors
    Florence Margai
    Department of Geography, Binghamton University, P O Box 6000, Binghamton, NY 13850, USA
    Soc Sci Med 56:1073-85. 2003
    ..Taken together, these results suggest the need for a more inclusive multi-disciplinary research on LD that extends beyond the classroom context to the neighborhoods and communities in which these children reside...
  90. ncbi Learning disorders in children and adolescents
    Helen D Pratt
    Division of Behavioral Developmental Pediatrics, Michigan State University, Kalamazoo Center for Medical Studies, Kalamazoo, MI 49008, USA
    Prim Care 34:361-74; abstract viii. 2007
    ..Parental attitudes and commitment, availability of resources, and the presence of an associated neurologic deficit or medical disorder can also significantly impact outcomes...
  91. pmc Developmental iodine deficiency resulting in hypothyroidism reduces hippocampal ERK1/2 and CREB in lactational and adolescent rats
    Jing Dong
    Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China
    BMC Neurosci 10:149. 2009
    ....
  92. ncbi Nicotine reverses adult-onset hypothyroidism-induced impairment of learning and memory: Behavioral and electrophysiological studies
    K H Alzoubi
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas 77204 5515, USA
    J Neurosci Res 84:944-53. 2006
    ..These results show that chronic nicotine treatment prevents hypothyroidism-induced impairment of spatial cognition and LTP...
  93. pmc Risk of learning and behavioral disorders following prenatal and early postnatal exposure to tetrachloroethylene (PCE)-contaminated drinking water
    Patricia A Janulewicz
    Department of Environmental Health, Boston University School of Public Health, Boston Massachusetts 02118, USA
    Neurotoxicol Teratol 30:175-85. 2008
    ..We conclude that prenatal and early postnatal PCE exposure is not associated with disorders of attention, learning and behavior identified on the basis of questionnaire responses and at the exposure levels experienced by this population...
  94. ncbi Neurobehavioral consequences of prenatal alcohol exposure: an international perspective
    Edward P Riley
    San Diego, State University, San Diego, California 92120, USA
    Alcohol Clin Exp Res 27:362-73. 2003
    ..Mattson, E. P. Riley, A. Matveeva, and G. Marintcheva; and (6) Long-term follow-up of Finnish children exposed to alcohol in utero in various durations, by Marit I. Korkman and I. Autti-Rämö. The discussant was Ting-Kai Li...
  95. pmc Selective reinforcement learning deficits in schizophrenia support predictions from computational models of striatal-cortical dysfunction
    James A Waltz
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
    Biol Psychiatry 62:756-64. 2007
    ..We investigated whether fronto-striatal dysfunction in schizophrenia (SZ) is characterized by selective impairment in either reward- (Go) or punishment-driven (NoGo) learning...
  96. ncbi Working memory impairments in children with attention-deficit hyperactivity disorder with and without comorbid language learning disorders
    Rhonda Martinussen
    Institute of Medical Science, University of Toronto, Canada
    J Clin Exp Neuropsychol 28:1073-94. 2006
    ..ADHD) are impaired on one or more components of working memory (WM) independent of comorbid language learning disorders, and whether WM impairments are more strongly related to symptoms of inattention than to symptoms of ..
  97. ncbi Genes, cognition and dyslexia: learning to read the genome
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
    Trends Cogn Sci 10:250-7. 2006
    ..Dissection of cognitive mechanisms that subserve reading will ultimately depend on an integrated approach, uniting data from genetic investigations, behavioural studies and neuroimaging...
  98. ncbi Electrophysiological dissociation between verbal and nonverbal semantic processing in learning disabled adults
    E Plante
    Department of Speech and Hearing Sciences, The University of Arizona, P O Box 210071, Tucson, AZ 85721 0071, USA
    Neuropsychologia 38:1669-84. 2000
    ..Semantic deficits in this group may reflect a relatively specific deficit in forming verbal associations rather than a more general difficulty that spans both verbal and nonverbal domains...
  99. ncbi Middle-class mothers' perceptions of peer and sibling victimization among children with Asperger's syndrome and nonverbal learning disorders
    Liza Little
    Family Research Laboratory and Department of Nursing, University of New Hampshire, Durham 03824, USA
    Issues Compr Pediatr Nurs 25:43-57. 2002
    ..by a large national sample of middle-class mothers of children with Asperger's syndrome and nonverbal learning disorders. An anonymous, mailed survey was sent to families solicited from two national Internet sites for parents of ..
  100. pmc Reinforcement and reversal learning in first-episode psychosis
    G K Murray
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Schizophr Bull 34:848-55. 2008
    ..Abnormalities in reinforcement learning and reversal learning have been reported in psychosis, possibly secondary to subcortical dopamine abnormalities...
  101. ncbi Developmental dyscalculia
    R S Shalev
    Neuropediatric Unit, Shaare Zedek Medical Center, Jerusalem 91031, Israel
    Pediatr Neurol 24:337-42. 2001
    ..The consequences of developmental dyscalculia and its impact on education, employment, and psychologic well-being of affected individuals are unknown...

Research Grants80

  1. A Developmental Study of Mathemetics Disabilities 2
    NANCY JORDAN; Fiscal Year: 2007
    ..We also expect the findings to have direct applications for the development of evidence-based math interventions. [unreadable] [unreadable]..
  2. Implicit Sequence Learning in Deaf Children with Cochlear Implants
    CHRISTOPHER CONWAY; Fiscal Year: 2010
    ..This knowledge will provide the theoretical and empirical foundation for improved prediction of and treatment for the deaf children who may be doing poorly with their implants. ..
  3. LEARNING DISABILITIES IN ELEMENTARY MATHEMATICS
    DAVID GEARY; Fiscal Year: 2003
    ....
  4. Mathematical Development in Learning Diasbled Children
    DAVID GEARY; Fiscal Year: 2003
    ..g., working memory) that underlie MD children's developmental delays and deficits in these competencies. ..
  5. Biochemical correlates/cognition/Barth syndrome
    MICHELE MAZZOCCO; Fiscal Year: 2004
    ..Methods will involve cognitive assessment of children with Barth syndrome and matched peers, paired comparisons, and correlation analyses. ..
  6. COGNITIVE AND GENETIC CORRELATES OF EARLY MATH SKILLS
    MICHELE MAZZOCCO; Fiscal Year: 2006
    ..abstract_text> ..
  7. Genetic Bases of Developmental Language Disorders
    Elena L Grigorenko; Fiscal Year: 2010
    ..abstract_text> ..
  8. Understanding/Preventing Math Problem/Solving Disability
    Lynn Fuchs; Fiscal Year: 2007
    ..abstract_text> ..
  9. DSM-IV ADHD IN AN ETHNICALLY DIVERSE COMMUNITY SAMPLE
    Erik Willcutt; Fiscal Year: 2004
    ..abstract_text> ..
  10. Validity of DSM-IV ADHD Subtypes in a Community Sample
    Erik Willcutt; Fiscal Year: 2005
    ....
  11. Reading disability QTLs: pooled DNA on microarrays
    Robert Plomin; Fiscal Year: 2008
    ..Identifying genes associated with reading disability will eventually lead to better diagnoses, individually tailored treatments, and interventions that can prevent the development of reading disability. ..
  12. Etiology of Reading Disabilities and Comorbid ADHD
    Erik Willcutt; Fiscal Year: 2009
    ..abstract_text> ..
  13. Creating Avenues for Parent Partnership (CAPP)
    Janice Buelow; Fiscal Year: 2008
    ..With the appropriate help, these children can learn to be productive members of society. [unreadable] [unreadable] [unreadable]..
  14. Adult Outcome of Attention Deficit Hyperactivity Disorder
    Joseph Biederman; Fiscal Year: 2007
    ..For these reasons, we expect the proposed work to clarify the course and outcome of ADHD. ..
  15. Collaborative Pediatric Bipolar Disorder Conference
    Joseph Biederman; Fiscal Year: 2007
    ..While the proposed conference does not intend to solve all outstanding problems associated with pediatric bipolar disorder, it will provide a forum to begin formulating a solution. ..
  16. Opiate Addiction and HIV-1 Induced Release of Cytokines
    William Banks; Fiscal Year: 2006
    ....
  17. Cotinine for Cognitive Impairment in Neurological and Neuropsychiatric Disorders
    Alvin V Terry; Fiscal Year: 2010
    ..The partly translational design of the study will provide results leading to eventual clinical trials with cotinine or a relevant analog. ..
  18. Metabolic Syndrome in Adult Survivors of Childhood ALL
    James Gurney; Fiscal Year: 2005
    ..abstract_text> ..
  19. Effects of Statins on AD beyond Cholesterol and Amyloid
    Ling Li; Fiscal Year: 2006
    ..abstract_text> ..
  20. Early School Progress in <1000g Birthweight Children
    H Gerry Taylor; Fiscal Year: 2010
    ..The findings will inform efforts to identify and treat learning disorders in high-risk children at school entry.
  21. DEVELOPMENTAL PLASTICITY AND CHRONIC EPILEPSY
    John Swann; Fiscal Year: 2007
    ..Since there are so few animal models of early-onset epilepsy, the studies proposed here offer a unique opportunity to further an understanding of the biological origins of seizure disorders in infancy. ..
  22. Receptive language skills in developmental language disorder
    ELENA M PLANTE; Fiscal Year: 2010
    ..Therefore, this research will provide a context for the development of improved intervention methods. ..
  23. Identification of Adults with Developmental Language Impairments
    Elena Plante; Fiscal Year: 2007
    ..This is a critical first step for genetic studies of this disorder, as well as research into the longterm outcome of this disorder and the residual deficits that characterize affected adults. [unreadable] [unreadable] [unreadable]..
  24. IONIC HOMEOSTASIS AND SEIZURE REGULATION
    John Swann; Fiscal Year: 2009
    ..This hypothesis will be directly tested by measuring changes in intracellular calcium in glial cells and neurons during stimulus trains in hippocampal slices while measuring extracellular calcium. ..
  25. Numerical Deficits Across Multiple Genetic Disorders
    Tony Simon; Fiscal Year: 2007
    ..It should be possible to use these results to develop interventions for children with numerical disabilities and improved teaching methods in the numerical domain for typically developing children. ..
  26. Course of psychopathology in female youth: Analysis with extant longitudinal data
    Joseph Biederman; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  27. Prion Transport Across the Blood-Brain Barrier
    William Banks; Fiscal Year: 2009
    ..To cause disease, prions must cross the blood-brain barrier to enter the brain. We will determine how prions cross the BBB. Knowing how prions enter the brain should lead to strategies on how to prevent prion diseases. ..
  28. RSA Lecture Series
    Jennifer Thomas; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  29. RECEPTIVE SKILLS IN DEVELOPMENTAL LANGUAGE DISORDER
    Elena Plante; Fiscal Year: 2007
    ..Therefore, this research will provide a context for the development of improved intervention methods. ..
  30. Antipsychotics: Temporal Effects on Cognitive Function
    Alvin Terry; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  31. PET IN PARKINSONISM: A MULTICENTER COLLABORATIVE STUDY
    David Eidelberg; Fiscal Year: 2003
    ..abstract_text> ..
  32. ASSESSMENT OF DISEASE PROGRESSION IN PARKINSONISM
    David Eidelberg; Fiscal Year: 2003
    ..He will also provide structured training in the fundamentals of experimental neurological research in using new functional brain imaging techniques. ..
  33. PREVENTION OF CIGARETTE SMOKING IN ADHD YOUTH
    Joseph Biederman; Fiscal Year: 2001
    ..Since there are estimated to be 3.5 million children with ADHD and 20% have been shown to be smokers, targeting this group could potentially impact 700,000 children and adolescents. ..
  34. NEUROBIOLOGY OF COGNITIVE IMPAIRMENT IN CHILDREN WITH NF
    Bartlett Moore; Fiscal Year: 2003
    ..and medical specialists involved with these patients, "Given that a particular child has or doesn't have brain anomalies, and does or does not have learning difficulties, what will this child be like in the future"? ..
  35. PTS1 Regulation of Brain Met Enk Levels in Alcoholism
    William Banks; Fiscal Year: 2004
    ..abstract_text> ..
  36. Mechanisms of HIV Transport Across the BBB
    William Banks; Fiscal Year: 2004
    ....
  37. Brain and Behavior in Dystonia: A Multicenter Study
    David Eidelberg; Fiscal Year: 2007
    ..Together, these studies will provide important information about the physiological mechanisms that underlie primary torsion dystonia, and the possible therapeutic effect of deep brain stimulation. ..
  38. LONGITUDINAL FOLLOW UP OF ADHD GIRLS AND THEIR SIBLINGS
    Joseph Biederman; Fiscal Year: 2002
    ....
  39. SCHOOL AGE CONSEQUENCES OF <750 GRAM BIRTHWEIGHT
    H Taylor; Fiscal Year: 2002
    ..Results will clarify the long-term sequelae of less than 750 g birth weight and shed light on the bases of both adverse consequences and developmental sparing. ..
  40. PET IN HYPERKINETIC DISORDERS--A MULTICENTER STUDY
    David Eidelberg; Fiscal Year: 2001
    ..This approach may have great utility in evaluating new interventions for the treatment of the hyperkinetic movement disorders. ..
  41. PRECLINICAL MODELS FOR HUMAN ASTROCYTOMAS
    David Gutmann; Fiscal Year: 2004
    ..abstract_text> ..
  42. Aging and Sites of Action of Cognition-Enhancing Drugs
    DIANA WOODRUFF PAK; Fiscal Year: 2008
    ..These studies will likely support hypotheses about ACh mechanisms in learning and memory and may identify the cerebellum as an additional site of drug action. [unreadable] [unreadable]..
  43. AAV-mediated muscle-directed gene transfer for Alzheimer's disease
    Ken Ichiro Fukuchi; Fiscal Year: 2008
    ..The long-term goal is to establish the logical basis for developing safe and effective gene therapy modalities for AD utilizing rAAV and scFv. [unreadable] [unreadable] [unreadable]..
  44. Perinatal infection, cytokines and brain injury
    Zhengwei Cai; Fiscal Year: 2008
    ....
  45. BEHAVIOR THERAPY FOR FAMILIES OF DIABETIC ADOLESCENTS
    Tim Wysocki; Fiscal Year: 2003
    ..These results could influence the clinical practice of diabetes management and health care policy regarding adolescents with diabetes and other chronic diseases. ..
  46. Screening Putative Therapeutic Agents for Fetal Ethanol-Induced Learning Deficits
    DANIEL SAVAGE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  47. Health and School Performance Among Youth Ages 9-13
    Christopher Forrest; Fiscal Year: 2009
    ..Our long-term goal for this research is to follow youth into high school and beyond to more fully characterize the evolution of health from childhood to adulthood. ..
  48. Functional Outcomes in Pediatric Liver Transplantation
    Estella Alonso; Fiscal Year: 2009
    ....
  49. PROMOTING ACADEMIC ACHIEVEMENT IN ADHD CHILDREN
    George DuPaul; Fiscal Year: 2004
    ....
  50. A Prospective Longitudinal Study of PANDAS
    James Leckman; Fiscal Year: 2005
    ..These insights may be relevant to our understanding of other diseases including AIDS. ..
  51. Longitudinal Twin Study of Reading Disability
    Sally Wadsworth; Fiscal Year: 2006
    ..Univariate and bivariate QTL analyses of reading deficits and ADHD, reading component processes and other psychopathology will also be conducted. ..
  52. NEURAL CIRCUITRY OF SENSORIMOTOR GATING ACROSS SPECIES
    Neal Swerdlow; Fiscal Year: 2006
    ....
  53. Pilot Project Core - CIFASD
    Edward Riley; Fiscal Year: 2005
    ..In this regard, a project was chosen with a potential of diagnosing FASD early in life, based upon ultrasound imaging of the corpus callos. ..
  54. Psychosocial Adjustment in Adolescents with Spina Bifida
    Grayson Holmbeck; Fiscal Year: 2009
    ..Moreover, the results will have implications for prevention and intervention efforts with families who have offspring with disabling birth defects. ..
  55. Reliability of Cognitive ERPs in Children and Adults
    Patricia Davies; Fiscal Year: 2006
    ..This information will be helpful, especially when clinical populations (e.g., attention deficit disorders and learning disabilities) are included in developmental ERP studies. [unreadable] [unreadable]..
  56. Cross-cultural FASD: Brain Imaging (U24 Core)
    ELIZABETH SOWELL; Fiscal Year: 2005
    ..abstract_text> ..
  57. B-Synuclein as a Treatment for Lewy Body Disease
    Eliezer Masliah; Fiscal Year: 2005
    ..abstract_text> ..
  58. Linking Affect to Action: Critical Contributions of the Orbitofrontal Cortex
    Geoffrey Schoenbaum; Fiscal Year: 2006
    ..The participation of minorities and women has been emphasized at each level (organizers, speakers, students). Thus the conference will address important scientific, social, and educational issues. [unreadable] [unreadable] [unreadable]..
  59. Determinants in Recovery from TBI in Children 0-3
    James Blackman; Fiscal Year: 2005
    ..This project will be far more comprehensive than previous studies of brain injury in infants and toddlers and will explore novel hypotheses regarding genetic determinants of outcome and markers of neuronal injury in young children. ..
  60. CaMKII and Neuronal Excitability Changes in Learning
    Masuo Ohno; Fiscal Year: 2007
    ..functions to establish learning and memory in brain will have relevance to the better understanding of mechanisms underlying learning deficits or dementia, and to developing novel strategies to treat learning disorders.
  61. TEACHER OPINION LEADERS & SERVICES FOR ADHD CHILDREN
    Marc Atkins; Fiscal Year: 2002
    ....
  62. Prefrontal Cortex and Striatum in Rule Selection
    Ilsun White; Fiscal Year: 2003
    ..abstract_text> ..
  63. GENETICS OF COGNITION IN ADULT TURNER SYNDROME
    Judith Ross; Fiscal Year: 2005
    ..Characterization of specific TS causative genes would provide insight into the pathophysiology of 45,X, Turner syndrome, as well as the process of normal neurocognitive development. ..
  64. MECHANISMS OF MEMORY DEFICITS FOLLOWING BRAIN INJURY
    Pramod Dash; Fiscal Year: 2006
    ..Furthermore, this project will broaden our understanding of the pathogenesis of neurodegenerative diseases such as stroke and Alzheimer's disease. ..
  65. Androgen effect on motor/cognitive outcome in Klinefelter syndrome
    Judith L Ross; Fiscal Year: 2010
    ..If successful, androgen replacement in the clinical management of KS would commence early in childhood rather than adolescence or adulthood. ..
  66. ANDROGEN EFFECTS ON COGNITION IN TURNER SYNDROME
    Judith Ross; Fiscal Year: 2007
    ..In addition, these data will help determine how to optimize cognitive function in Turner syndrome and will extend knowledge of the mechanisms of male/female cognitive dimorphisms. ..
  67. Work injury and young people: A prospective survey
    F Breslin; Fiscal Year: 2005
    ..No study to date has examined the impact of work injuries on earnings losses among young workers, thereby addressing a notable gap in this research area. ..
  68. A SCHOOL PROGRAM FOR CHILDREN EXPOSED TO VIOLENCE
    Lisa Jaycox; Fiscal Year: 2006
    ..Specifically, this work falls under the research priority of prevention and intervention programs and services for children exposed to violence listed in the announcement. [unreadable] [unreadable]..
  69. PSYCHOPHYSIOLOGY OF ADAPTATION--CHILDREN IN HEAD START
    Clancy Blair; Fiscal Year: 2002
    ....
  70. MULTISITE PREVENTION OF ADOLESCENT CONDUCT PROBLEMS
    Karen Bierman; Fiscal Year: 2007
    ..abstract_text> ..
  71. A Randomized Trial of the STAR Program for Children with Autism Spectrum Disorder
    David Mandell; Fiscal Year: 2009
    ..Findings from the proposed study would provide timely and critical evidence regarding the implementation and effectiveness of one promising practice, with direct relevance to translation of findings into practice and policy. ..
  72. Early Childhood Education and School Readiness Planning
    Karen Bierman; Fiscal Year: 2002
    ..abstract_text> ..
  73. Friendship and psychosocial adjustment in adolescence
    Kenneth Rubin; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  74. Diffuse optical brain imaging for stroke rehabilitation
    Gary Strangman; Fiscal Year: 2007
    ..Importantly, use of the DOT technology in such a research program is expected to enable the investigation of tasks and populations that are otherwise beyond the reach of existing brain imaging technologies. [unreadable] [unreadable]..
  75. Diffuse optical imaging of intracranial pressure changes
    Gary Strangman; Fiscal Year: 2004
    ....
  76. Effects of Botanicals on Cognition in Midlife Women
    Pauline Maki; Fiscal Year: 2005
    ..Recent findings of significant health risks associated with Prempro heighten the need for research into the effects of alternative therapies for menopausal symptoms on cognitive outcomes. ..
  77. Research on Reading Instructions for Low Literate Adults
    DAPHNE GREENBERG; Fiscal Year: 2006
    ..In addition, we will scan 5 participants from each of our 6 groups before they receive instruction and after the 100th hour is completed. ..
  78. Self-Regulation in Co-Occurring TBI and Substance Abuse
    Jennifer Bogner; Fiscal Year: 2006
    ..abstract_text> ..