developmental disabilities

Summary

Summary: Disorders in which there is a delay in development based on that expected for a given age level or stage of development. These impairments or disabilities originate before age 18, may be expected to continue indefinitely, and constitute a substantial impairment. Biological and nonbiological factors are involved in these disorders. (From American Psychiatric Glossary, 6th ed)

Top Publications

  1. ncbi Cognitive and behavioral outcomes of school-aged children who were born preterm: a meta-analysis
    Adnan T Bhutta
    Department of Pediatrics, Arkansas University for Medical Sciences, Little Rock, USA
    JAMA 288:728-37. 2002
  2. pmc Consensus statement: chromosomal microarray is a first-tier clinical diagnostic test for individuals with developmental disabilities or congenital anomalies
    David T Miller
    Division of Genetics and Department of Laboratory Medicine, Children s Hospital Boston and Harvard Medical School, Boston, MA, USA
    Am J Hum Genet 86:749-64. 2010
  3. ncbi Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy
    Seetha Shankaran
    Division of Neonatal Perinatal Medicine, Wayne State University, Children s Hospital of Michigan, Detroit, MI 48201, USA
    N Engl J Med 353:1574-84. 2005
  4. ncbi Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection
    Barbara J Stoll
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    JAMA 292:2357-65. 2004
  5. pmc An evidence-based approach to establish the functional and clinical significance of copy number variants in intellectual and developmental disabilities
    Erin B Kaminsky
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Genet Med 13:777-84. 2011
  6. ncbi Neonatal MRI to predict neurodevelopmental outcomes in preterm infants
    Lianne J Woodward
    Canterbury Child Development Research Group, Department of Psychology, University of Canterbury and the Van der Veer Institute for Parkinson s and Brain Research, Christchurch, New Zealand
    N Engl J Med 355:685-94. 2006
  7. ncbi Neurologic and developmental disability at six years of age after extremely preterm birth
    Neil Marlow
    School of Human Development, University of Nottingham, Nottingham, United Kingdom
    N Engl J Med 352:9-19. 2005
  8. ncbi Abnormal cerebral structure is present at term in premature infants
    Terrie E Inder
    Murdoch Children s Research Institute, Royal Women s Hospital, University of Melbourne, Melbourne, Australia
    Pediatrics 115:286-94. 2005
  9. ncbi Trends in the prevalence of developmental disabilities in US children, 1997-2008
    Coleen A Boyle
    National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Pediatrics 127:1034-42. 2011
  10. ncbi Developmental dyscalculia and basic numerical capacities: a study of 8-9-year-old students
    Karin Landerl
    Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London WC1N 3AR, UK
    Cognition 93:99-125. 2004

Detail Information

Publications371 found, 100 shown here

  1. ncbi Cognitive and behavioral outcomes of school-aged children who were born preterm: a meta-analysis
    Adnan T Bhutta
    Department of Pediatrics, Arkansas University for Medical Sciences, Little Rock, USA
    JAMA 288:728-37. 2002
    ..The cognitive and behavioral outcomes of school-aged children who were born preterm have been reported extensively. Many of these studies have methodological flaws that preclude an accurate estimate of the long-term outcomes of prematurity...
  2. pmc Consensus statement: chromosomal microarray is a first-tier clinical diagnostic test for individuals with developmental disabilities or congenital anomalies
    David T Miller
    Division of Genetics and Department of Laboratory Medicine, Children s Hospital Boston and Harvard Medical School, Boston, MA, USA
    Am J Hum Genet 86:749-64. 2010
    ..G-banded karyotype analysis should be reserved for patients with obvious chromosomal syndromes (e.g., Down syndrome), a family history of chromosomal rearrangement, or a history of multiple miscarriages...
  3. ncbi Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy
    Seetha Shankaran
    Division of Neonatal Perinatal Medicine, Wayne State University, Children s Hospital of Michigan, Detroit, MI 48201, USA
    N Engl J Med 353:1574-84. 2005
    ..Hypothermia is protective against brain injury after asphyxiation in animal models. However, the safety and effectiveness of hypothermia in term infants with encephalopathy is uncertain...
  4. ncbi Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection
    Barbara J Stoll
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    JAMA 292:2357-65. 2004
    ..Neonatal infections are frequent complications of extremely low-birth-weight (ELBW) infants receiving intensive care...
  5. pmc An evidence-based approach to establish the functional and clinical significance of copy number variants in intellectual and developmental disabilities
    Erin B Kaminsky
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Genet Med 13:777-84. 2011
    ..chromosomal microarray analysis as a first-tier diagnostic test for individuals with unexplained developmental disabilities provides a unique opportunity to obtain large copy number variant datasets generated through routine ..
  6. ncbi Neonatal MRI to predict neurodevelopmental outcomes in preterm infants
    Lianne J Woodward
    Canterbury Child Development Research Group, Department of Psychology, University of Canterbury and the Van der Veer Institute for Parkinson s and Brain Research, Christchurch, New Zealand
    N Engl J Med 355:685-94. 2006
    ..Very preterm infants are at high risk for adverse neurodevelopmental outcomes. Magnetic resonance imaging (MRI) has been proposed as a means of predicting neurodevelopmental outcomes in this population...
  7. ncbi Neurologic and developmental disability at six years of age after extremely preterm birth
    Neil Marlow
    School of Human Development, University of Nottingham, Nottingham, United Kingdom
    N Engl J Med 352:9-19. 2005
    Birth before 26 weeks of gestation is associated with a high prevalence of neurologic and developmental disabilities in the infant during the first two years of life.
  8. ncbi Abnormal cerebral structure is present at term in premature infants
    Terrie E Inder
    Murdoch Children s Research Institute, Royal Women s Hospital, University of Melbourne, Melbourne, Australia
    Pediatrics 115:286-94. 2005
    ..However, there is a limited understanding of the nature of the cerebral abnormality underlying these adverse neurologic outcomes...
  9. ncbi Trends in the prevalence of developmental disabilities in US children, 1997-2008
    Coleen A Boyle
    National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Pediatrics 127:1034-42. 2011
    To fill gaps in crucial data needed for health and educational planning, we determined the prevalence of developmental disabilities in US children and in selected populations for a recent 12-year period.
  10. ncbi Developmental dyscalculia and basic numerical capacities: a study of 8-9-year-old students
    Karin Landerl
    Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London WC1N 3AR, UK
    Cognition 93:99-125. 2004
    ..We conclude that dyscalculia is the result of specific disabilities in basic numerical processing, rather than the consequence of deficits in other cognitive abilities...
  11. pmc Mutations in PNKP cause microcephaly, seizures and defects in DNA repair
    Jun Shen
    1 Howard Hughes Medical Institute, Department of Neurology, Beth Israel Deaconess Medical Center and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts, USA 2 These authors contributed equally to the work
    Nat Genet 42:245-9. 2010
    ..Unlike other DNA repair defects that affect humans, PNKP mutations universally cause severe seizures. The neurological abnormalities in individuals with MCSZ may reflect a role for PNKP in several DNA repair pathways...
  12. ncbi Neurodevelopmental disability through 11 years of age in children born before 26 weeks of gestation
    Samantha Johnson
    Neonatology, Institute for Women s Health, University College London, London, United Kingdom
    Pediatrics 124:e249-57. 2009
    ..To assess functional disability in children born before 26 weeks of gestation at 11 years of age and the stability of findings in individuals between 6 and 11 years of age...
  13. pmc Deletions of NRXN1 (neurexin-1) predispose to a wide spectrum of developmental disorders
    Michael S L Ching
    Division of Developmental Medicine, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Am J Med Genet B Neuropsychiatr Genet 153:937-47. 2010
    ..Our study indicates that deletions of NRXN1 predispose to a wide spectrum of developmental disorders...
  14. ncbi Symbolic and nonsymbolic number comparison in children with and without dyscalculia
    Christophe Mussolin
    Cognition and Development Department, Louvain School of Psychology, Catholic University of Louvain, B 1348 Louvain la Neuve, Belgium
    Cognition 115:10-25. 2010
    ..This favours a deficit in the specialised cognitive system underlying the processing of number magnitude in children with DD. Results are discussed in terms of access and representation deficit hypotheses...
  15. ncbi Early brain injury in premature newborns detected with magnetic resonance imaging is associated with adverse early neurodevelopmental outcome
    Steven P Miller
    Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA
    J Pediatr 147:609-16. 2005
    ..To determine the neurodevelopmental outcome of prematurely born newborns with magnetic resonance imaging (MRI) abnormalities...
  16. ncbi Neurodevelopmental disabilities and special care of 5-year-old children born before 33 weeks of gestation (the EPIPAGE study): a longitudinal cohort study
    Beatrice Larroque
    INSERM, UMR S149, IFR69, Research Unit on Perinatal Health and Women s Health, Villejuif, France Université Pierre et Marie Curie Paris 6, Paris, France
    Lancet 371:813-20. 2008
    ..We aimed to investigate neurodevelopmental outcome and use of special health care at 5 years of age in a population-based cohort of very preterm children...
  17. ncbi Diagnostic yield of various genetic approaches in patients with unexplained developmental delay or mental retardation
    Anita Rauch
    Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Am J Med Genet A 140:2063-74. 2006
    ..If molecular karyotyping is not available, subtelomeric screening should be performed...
  18. ncbi Improved survival rates with increased neurodevelopmental disability for extremely low birth weight infants in the 1990s
    Deanne Wilson-Costello
    Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA
    Pediatrics 115:997-1003. 2005
    ....
  19. pmc Intensive care for extreme prematurity--moving beyond gestational age
    Jon E Tyson
    Center for Clinical Research and Evidence Based Medicine, University of Texas Medical School at Houston, Houston, TX 77030, USA
    N Engl J Med 358:1672-81. 2008
    ..Decisions regarding whether to administer intensive care to extremely premature infants are often based on gestational age alone. However, other factors also affect the prognosis for these patients...
  20. pmc Developmental potential in the first 5 years for children in developing countries
    Sally Grantham-McGregor
    Centre for International Child Health, Institute of Child Health, University College London, UK
    Lancet 369:60-70. 2007
    ..These disadvantaged children are likely to do poorly in school and subsequently have low incomes, high fertility, and provide poor care for their children, thus contributing to the intergenerational transmission of poverty...
  21. ncbi Neurodevelopmental and functional outcomes of extremely low birth weight infants in the National Institute of Child Health and Human Development Neonatal Research Network, 1993-1994
    B R Vohr
    Women and Infants Hospital, Providence, Rhode Island 02905, USA
    Pediatrics 105:1216-26. 2000
    ....
  22. ncbi Impact of sepsis on neurodevelopmental outcome in a Swiss National Cohort of extremely premature infants
    Luregn J Schlapbach
    NICU and PICU, Department of Pediatrics, Inselspital, University of Bern, 3010 Bern, Switzerland
    Pediatrics 128:e348-57. 2011
    ..This study aimed to determine the impact of sepsis on neurodevelopment at 2 years' corrected age in extremely preterm infants...
  23. ncbi Increased risk of adverse neurological development for late preterm infants
    Joann R Petrini
    Perinatal Data Center, March of Dimes National Office, White Plains, NY 10605, USA
    J Pediatr 154:169-76. 2009
    ..To assess the risks of moderate prematurity for cerebral palsy (CP), developmental delay/mental retardation (DD/MR), and seizure disorders in early childhood...
  24. ncbi Error-related processing dysfunction in children aged 9 to 12 years presenting putative antecedents of schizophrenia
    Kristin R Laurens
    Department of Forensic Mental Health Science, Institute of Psychiatry, King s College London, London SE5 8AF, United Kingdom
    Biol Psychiatry 67:238-45. 2010
    ..This study examined whether ASz children display brain function abnormalities during error processing that are similar to those exhibited by adults with schizophrenia...
  25. pmc Prenatal dichlorodiphenyldichloroethylene (DDE) exposure and neurodevelopment: a follow-up from 12 to 30 months of age
    Luisa Torres-Sanchez
    Instituto Nacional de Salud Publica, Morelos, Mexico
    Neurotoxicology 30:1162-5. 2009
    ..001). The association of DDE with infant neurodevelopment seems to be reversible. However, we cannot rule out that other DDT metabolites may play a role in neurodevelopment...
  26. ncbi Functioning at school age of moderately preterm children born at 32 to 36 weeks' gestational age
    Anneloes L van Baar
    Department of Pediatric Psychology, Tilburg University, Tilburg, Netherlands
    Pediatrics 124:251-7. 2009
    ..To study outcome of low-risk moderately preterm birth between 32 and 36/7 weeks' gestation...
  27. pmc Developmental brain dysfunction: revival and expansion of old concepts based on new genetic evidence
    Andres Moreno-De-Luca
    Autism and Developmental Medicine Institute, Geisinger Health System, Danville, PA 17822, USA
    Lancet Neurol 12:406-14. 2013
    ....
  28. ncbi Preliminary evidence of abnormal white matter related to the fusiform gyrus in Williams syndrome: a diffusion tensor imaging tractography study
    B W Haas
    Department of Psychiatry and Behavioral Sciences, Center for Interdisciplinary Brain Sciences Research, Stanford University School of Medicine, Palo Alto, CA, USA
    Genes Brain Behav 11:62-8. 2012
    ..No between-group differences were observed in the fibers that project through the control regions. Although preliminary, these results provide further evidence that the brain anatomy important for processing faces is abnormal in WS...
  29. ncbi Very preterm children show impairments across multiple neurodevelopmental domains by age 4 years
    L J Woodward
    Canterbury Child Development Research Group, Department of Psychology, University of Canterbury, Christchurch, New Zealand
    Arch Dis Child Fetal Neonatal Ed 94:F339-44. 2009
    ..Of particular interest were children's risks of impairment across multiple neurodevelopmental domains...
  30. ncbi Academic attainment and special educational needs in extremely preterm children at 11 years of age: the EPICure study
    S Johnson
    Institute for Women s Health, University College, 286 96 Chenies Mews, London WC1E 6HX, UK
    Arch Dis Child Fetal Neonatal Ed 94:F283-9. 2009
    ..To assess academic attainment and special educational needs (SEN) in extremely preterm children in middle childhood...
  31. pmc Chlorpyrifos exposure and urban residential environment characteristics as determinants of early childhood neurodevelopment
    Gina S Lovasi
    Columbia University, New York, NY, USA
    Am J Public Health 101:63-70. 2011
    ....
  32. ncbi The stability of the diagnosis of developmental disability between ages 2 and 8 in a geographic cohort of very preterm children born in 1997
    G Roberts
    Department of Obstetrics and Gynaecology, The Royal Women s Hospital, 20 Flemington Road, Parkville, VIC 3052, Australia
    Arch Dis Child 95:786-90. 2010
    ....
  33. ncbi Neurodevelopmental and growth outcomes of extremely low birth weight infants after necrotizing enterocolitis
    Susan R Hintz
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, 750 Welch Rd, Suite 315, Palo Alto, CA 94304, USA
    Pediatrics 115:696-703. 2005
    ..The objective of this study was to compare growth, neurologic, and cognitive outcomes among ELBW survivors of SurgNEC and MedNEC with NoNEC at 18 to 22 months' corrected age...
  34. ncbi An interdisciplinary bronchopulmonary dysplasia program is associated with improved neurodevelopmental outcomes and fewer rehospitalizations
    E G Shepherd
    Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA
    J Perinatol 32:33-8. 2012
    ....
  35. ncbi Neonatal magnetic resonance imaging and outcome at age 30 months in extremely preterm infants
    Béatrice Skiöld
    Department of Women s and Children s Health, Karolinska Institute, Stockholm, Sweden
    J Pediatr 160:559-566.e1. 2012
    ..To examine associations between brain white matter abnormalities, including diffuse excessive high signal intensities, detected on neonatal magnetic resonance imaging (MRI) with neurodevelopmental outcome at age 30 months...
  36. ncbi Relationship between attrition and neurodevelopmental impairment rates in extremely preterm infants at 18 to 24 months: a systematic review
    Ursula Guillen
    Division of Neonatology, The Children s Hospital of Philadelphia, PA 19104, USA
    Arch Pediatr Adolesc Med 166:178-84. 2012
    ..To assess the effect of loss to follow-up rates at 18 to 24 months on neurodevelopmental outcome statistics for infants of less than 1000 g birth weight or less than 28 weeks' gestational age...
  37. ncbi Outcomes at 2 years of age after repeat doses of antenatal corticosteroids
    Caroline A Crowther
    Disciplines of Obstetrics and Gynaecology, University of Adelaide, Women s and Children s Hospital, Adelaide, Australia
    N Engl J Med 357:1179-89. 2007
    ..However, data have not been available regarding longer-term effects of this treatment...
  38. ncbi Long-term outcomes of group B streptococcal meningitis
    Romina Libster
    Vanderbilt Vaccine Research Program, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Pediatrics 130:e8-15. 2012
    ..We evaluated long-term outcomes among GBS meningitis survivors. We hypothesized that despite reduced mortality, GBS meningitis would remain a significant cause of morbidity among GBS survivors...
  39. ncbi Neurodevelopmental screening in toddlers and early preschoolers with sickle cell disease
    Jeffrey Schatz
    Department of Psychology, University of South Carolina, Columbia, SC 29208, USA
    J Child Neurol 23:44-50. 2008
    ..The Denver II may be a useful behavioral screening tool for neurodevelopmental risk in sickle cell disease...
  40. ncbi Disorders of childhood and adolescence: gender and psychopathology
    Carolyn Zahn-Waxler
    Senior Scientist, Department of Psychology, University of Wisconsin, Madison, Wisconsin 53726 1696, USA
    Annu Rev Clin Psychol 4:275-303. 2008
    ..At the same time, because boys and girls also show many similarities, it is important to avoid sex-stereotyping mental health problems...
  41. pmc Trajectories of early brain volume development in fragile X syndrome and autism
    Heather Cody Hazlett
    University of North Carolina at Chapel Hill and the Carolina Institute for Developmental Disabilities, NC 27599 2267, USA
    J Am Acad Child Adolesc Psychiatry 51:921-33. 2012
    ..To examine patterns of early brain growth in young children with fragile X syndrome (FXS) compared with a comparison group (controls) and a group with idiopathic autism...
  42. pmc Superior longitudinal fasciculus and cognitive dysfunction in adolescents born preterm and at term
    Richard E Frye
    Department of Pediatrics, University of Texas Health Science Center, Houston, TX 77030, USA
    Dev Med Child Neurol 52:760-6. 2010
    ..To understand the relationship between cognition and white-matter structure in adolescents born preterm without obvious brain injury...
  43. pmc Health disparities among adults with developmental disabilities, adults with other disabilities, and adults not reporting disability in North Carolina
    Susan M Havercamp
    Center for Development and Learning, University Center for Excellence in Developmental Disabilities, School of Medicine, University of North Carolina at Chapel Hill, 27599 7255, USA
    Public Health Rep 119:418-26. 2004
    The purposes of this study were (1) to identify disparities between adults with developmental disabilities and non-disabled adults in health and medical care, and (2) to compare this pattern of disparities to the pattern of disparities ..
  44. ncbi Association between deletion size and important phenotypes expands the genomic region of interest in Phelan-McDermid syndrome (22q13 deletion syndrome)
    Sara M Sarasua
    Office of Bioinformatics and Epidemiology, Greenwood Genetic Center, Greenwood, South Carolina 29646, USA
    J Med Genet 48:761-6. 2011
    ..Patient deletion sizes are also highly variable, prompting this genotype-phenotype association study...
  45. ncbi Relationship between test scores using the second and third editions of the Bayley Scales in extremely preterm children
    Tamanna Moore
    Research Department of Academic Neonatology, UCL Institute for Women s Health, University College London, London, UK
    J Pediatr 160:553-8. 2012
    ....
  46. ncbi The use of developmental neurotoxicity data in pesticide risk assessments
    Kathleen C Raffaele
    Office of Research and Development, U S Environmental Protection Agency, 1200 Pennsylvania Ave, Washington, DC 20460, USA
    Neurotoxicol Teratol 32:563-72. 2010
    ....
  47. ncbi Adverse neurodevelopment in preterm infants with postnatal sepsis or necrotizing enterocolitis is mediated by white matter abnormalities on magnetic resonance imaging at term
    Divyen K Shah
    Department of Pediatrics, Washington University, St Louis, MO 63105, USA
    J Pediatr 153:170-5, 175.e1. 2008
    ..To test the hypothesis that the impact of postnatal sepsis/necrotizing enterocolitis (NEC) on neurodevelopment may be mediated by white matter abnormality (WMA), which can be demonstrated with magnetic resonance imaging (MRI)...
  48. ncbi Neurodevelopmental outcomes of extremely low birth weight infants exposed prenatally to dexamethasone versus betamethasone
    Ben H Lee
    Division of Neonatal Perinatal Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Pediatrics 121:289-96. 2008
    ..We compared the development of adverse neurodevelopmental outcomes at corrected ages of 18 to 22 months for extremely low birth weight infants exposed prenatally to dexamethasone, betamethasone, or no steroid...
  49. ncbi Deletion and duplication of 15q24: molecular mechanisms and potential modification by additional copy number variants
    Ayman W El-Hattab
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genet Med 12:573-86. 2010
    ..To investigate the potential influence of additional copy number variants in patients with 15q24 rearrangements and the possible underlying mechanisms for these rearrangements...
  50. ncbi The development and maintenance of anxiety symptoms from infancy through adolescence in a longitudinal sample
    Michelle Bosquet
    Boston Medical Center, Boston University School of Medicine, USA
    Dev Psychopathol 18:517-50. 2006
    ..The results support a developmental model of the etiology and maintenance of anxiety symptoms in childhood and highlight factors to consider in efforts to prevent and treat childhood anxiety...
  51. pmc Recurrent reciprocal 16p11.2 rearrangements associated with global developmental delay, behavioural problems, dysmorphism, epilepsy, and abnormal head size
    Marwan Shinawi
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, NAB 2015, Houston, Texas 77030, USA
    J Med Genet 47:332-41. 2010
    ..Deletion and the reciprocal duplication in 16p11.2 were recently associated with autism and developmental delay...
  52. pmc Educational and behavioural problems in babies of 32-35 weeks gestation
    C L Huddy
    Neonatal Unit, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, UK
    Arch Dis Child Fetal Neonatal Ed 85:F23-8. 2001
    ..To identify incidence of school and behaviour problems at age 7 years in children born between 32 and 35 weeks gestation, and investigate perinatal risk factors...
  53. ncbi The epidemiology of developmental disabilities in low-income countries
    Maureen Durkin
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032
    Ment Retard Dev Disabil Res Rev 8:206-11. 2002
    ..and may be at high risk for disability, very little is known about the prevalence and causes of developmental disabilities in these countries...
  54. ncbi Clinically relevant single gene or intragenic deletions encompassing critical neurodevelopmental genes in patients with developmental delay, mental retardation, and/or autism spectrum disorders
    Fady M Mikhail
    Department of Genetics, University of Alabama at Birmingham, 35294, USA
    Am J Med Genet A 155:2386-96. 2011
    ....
  55. pmc Genomic copy number variation in disorders of cognitive development
    Eric M Morrow
    Brown University and Developmental Disorders Genetics Research Program, Emma Pendleton Bradley Hospital, Providence, RI, USA
    J Am Acad Child Adolesc Psychiatry 49:1091-104. 2010
    ..To emphasize new principles emerging from this area, involving the genetic architecture of disease, pathophysiology, and diagnosis...
  56. pmc Positive screening for autism in ex-preterm infants: prevalence and risk factors
    Catherine Limperopoulos
    Department of Neurology and Neurosurgery, School of Physical and Occupational Therapy, McGill University, Montreal, Quebec, Canada
    Pediatrics 121:758-65. 2008
    ..The objective of this study was to perform screening tests for early autistic features in children with a history of very low birth weight and to identify risk factors associated with a positive screening result...
  57. ncbi Caudate and hippocampal volumes, intelligence, and motor impairment in 7-year-old children who were born preterm
    Laurence J Abernethy
    Department of Medical Imaging, Royal Liverpool Children s Hospital, Eaton Road, Liverpool L12 2AP, United Kingdom
    Pediatr Res 55:884-93. 2004
    ..These findings suggest abnormal brain development after perinatal injury or postnatal nutritional deficits is responsible for cognitive deficits in preterm children...
  58. ncbi Long-term follow-up of 114 patients with congenital hyperinsulinism
    Thomas Meissner
    Clinic of General Pediatrics, University Children s Hospital, Dusseldorf, Germany
    Eur J Endocrinol 149:43-51. 2003
    ..The term congenital hyperinsulinism (CHI) comprises a group of different genetic disorders with the common finding of recurrent episodes of hyperinsulinemic hypoglycemia...
  59. ncbi Very preterm birth is associated with disabilities in multiple developmental domains
    Anneloes L van Baar
    Department of Psychology and Health, Pediatric Psychology, Tilburg University, Tilburg, The Netherlands
    J Pediatr Psychol 30:247-55. 2005
    ..Presence of disabilities in more than one developmental domain will show a more serious outcome picture for extreme preterm infants and may be related to a different degree of perinatal problems...
  60. ncbi Screening for developmental and behavioral problems
    Frances Page Glascoe
    Adjunct Professor of Pediatrics, Division of Developmental Pediatrics, Vanderbilt University, Nashville, TN, USA
    Ment Retard Dev Disabil Res Rev 11:173-9. 2005
    ..g., Brigance screens). Screening measures should be used in the context of developmental surveillance; the longitudinal process of incorporating professional observations into decision-making about children's developmental needs...
  61. ncbi Development in infants with autism spectrum disorders: a prospective study
    Rebecca Landa
    The Kennedy Krieger Institute, Center for Autism and Related Disorders, The Johns Hopkins School of Medicine, MD 21211, USA
    J Child Psychol Psychiatry 47:629-38. 2006
    ..Little is known about when or how development becomes disrupted in the first two years of life in autism. Such information is needed to facilitate early detection and early intervention...
  62. pmc Long-term cognitive and behavioral consequences of neonatal encephalopathy following perinatal asphyxia: a review
    Mariëlle van Handel
    Department of Neonatology, University Medical Center Utrecht Wilhelmina Children s Hospital, Heidelberglaan 1, 3584 CS Utrecht, P O Box 85500, 3500 GA, Utrecht, The Netherlands
    Eur J Pediatr 166:645-54. 2007
    ..A few studies suggest elevated rates of hyperactivity in children with moderate NE and autism in children with moderate and severe NE...
  63. ncbi Screening for speech and language delay in preschool children: systematic evidence review for the US Preventive Services Task Force
    Heidi D Nelson
    Department of Medical Informatics, Oregon Health and Science University, Portland, Oregon 97239, USA
    Pediatrics 117:e298-319. 2006
    ..However, optimal methods for screening for speech and language delay have not been identified, and screening is practiced inconsistently in primary care...
  64. ncbi Population cohort associating chorioamnionitis, cord inflammatory cytokines and neurologic outcome in very preterm, extremely low birth weight infants
    Tuula Kaukola
    Department of Pediatrics, University of Oulu, FIN 90014 Oulu, Finland
    Pediatr Res 59:478-83. 2006
    ..We propose that HCA together with other insults (placental perfusion defect or maternal systemic infection) increases the risk of poor neurologic outcome in very preterm ELBW infants...
  65. ncbi Congenital cardiac disease in the newborn infant: past, present, and future
    Sharyl L Sadowski
    Perinatal Center, Division of Obstetrics and Gynecology, University of Illinois at Chicago, 820 South Wood Street, Chicago, IL 60612, USA
    Crit Care Nurs Clin North Am 21:37-48, vi. 2009
    ..This article discusses the embryology, pathogenesis, clinical presentation, incidence, classifications, and management of congenital heart diseases...
  66. pmc Large, rare chromosomal deletions associated with severe early-onset obesity
    Elena G Bochukova
    University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nature 463:666-70. 2010
    ..Deletion carriers exhibited hyperphagia and severe insulin resistance disproportionate for the degree of obesity. We show that copy number variation contributes significantly to the genetic architecture of human obesity...
  67. ncbi Thyroid hormones states and brain development interactions
    Osama M Ahmed
    Zoology Department, Faculty of Science, Beni Suef University, Egypt
    Int J Dev Neurosci 26:147-209. 2008
    ..Thus, further studies need to be done to emphasize this concept...
  68. ncbi Prevalence and risk factors of neurological disability and impairment in children living in rural Kenya
    V Mung'ala-Odera
    Center for Geographic Medicine Coast, Kenya Medical Research Institute, PO 428, Kilifi, Kenya
    Int J Epidemiol 35:683-8. 2006
    ..There is little data on the burden of neurological impairment (NI) in developing countries, particularly in children of Africa...
  69. ncbi Neurodevelopmental outcomes of infants born prematurely
    Glen P Aylward
    Division of Developmental and Behavioral Pediatrics, Southern Illinois University School of Medicine, Springfield 62794 9658, USA
    J Dev Behav Pediatr 26:427-40. 2005
    ..Better assessment techniques measuring functions documented to be at higher risk of problems are discussed...
  70. ncbi Schizophrenia as a disorder of neurodevelopment
    David A Lewis
    Department of Psychiatry, University of Pittsburgh School of Medicine, University of Pittsburgh, Pennsylvania 15213, USA
    Annu Rev Neurosci 25:409-32. 2002
    ....
  71. ncbi The potential repercussions of maternal, fetal, and neonatal hypothyroxinemia on the progeny
    D Glinoer
    University Hospital Saint Pierre, Department of Internal Medicine Thyroid Investigation Clinic, Brussels, Belgium
    Thyroid 10:871-87. 2000
    ....
  72. ncbi Neurodevelopmental outcomes of very low-birth-weight infants with necrotizing enterocolitis: a systematic review of observational studies
    Sven M Schulzke
    Department of Neonatal Paediatrics, King Edward Memorial Hospital for Women, 374 Bagot Rd, Subiaco, Perth, Western Australia 6008, Australia
    Arch Pediatr Adolesc Med 161:583-90. 2007
    ..To systematically review observational studies reporting long-term neurodevelopmental outcomes in very low-birth-weight neonates surviving after necrotizing enterocolitis (NEC)...
  73. ncbi Amplitude-integrated EEG is useful in predicting neurodevelopmental outcome in full-term infants with hypoxic-ischemic encephalopathy: a meta-analysis
    R Edwin Spitzmiller
    Department of Pediatrics, Division of Neonatology, University of Cincinnati and the Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    J Child Neurol 22:1069-78. 2007
    ....
  74. ncbi Underestimation of developmental delay by the new Bayley-III Scale
    Peter J Anderson
    Murdoch Childrens Research Institute, Melbourne, Australia
    Arch Pediatr Adolesc Med 164:352-6. 2010
    ..To assess the ability of the third edition of the Bayley Scales of Infant and Toddler Development (Bayley-III) to detect developmental delay in 2-year-old children who were extremely preterm and those carried to term...
  75. ncbi Gender differences of children's developmental trajectory from 6 to 60 months in the Taiwan Birth Cohort Pilot Study
    For Wey Lung
    Department of Psychiatry, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan
    Res Dev Disabil 32:100-6. 2011
    ..The TBCS scale is a valid and reliable developmental screening instrument that can be used in continuous surveillance of children's development in community and clinical settings from 6 months to 5 years of age...
  76. pmc Caring for children with disabilities in Kilifi, Kenya: what is the carer's experience?
    J K Gona
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    Child Care Health Dev 37:175-83. 2011
    ..This study investigated the challenges encountered by these carers and the mechanisms of coping with these challenges while caring for children with disabilities in a poor rural setting in Kenya...
  77. ncbi Attention problems of very preterm children compared with age-matched term controls at school-age
    Jorrit F de Kieviet
    Department of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, The Netherlands
    J Pediatr 161:824-9. 2012
    ..To clarify the severity, specificity, and neurocognitive underpinnings of attention problems in very preterm children...
  78. ncbi A quantitative review of mortality and developmental disability in extremely premature newborns
    J M Lorenz
    Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, USA
    Arch Pediatr Adolesc Med 152:425-35. 1998
    ..To summarize the literature on mortality rates and prevalences of major neurodevelopmental disabilities and to examine trends of these outcomes over time in extremely premature neonates...
  79. ncbi Neuropathological features in a female fetus with OPHN1 deletion and cerebellar hypoplasia
    Delphine Rocas
    Hospices Civils de Lyon, Service de Genetique, F 69677 Bron, France
    Eur J Med Genet 56:270-3. 2013
    ..This condition mostly affects male fetuses in humans. We report here the first case of a de novo partial deletion of OPHN1, with radiological and neuropathological examination, in a female fetus...
  80. ncbi Outcomes at age 2 years of infants < 28 weeks' gestational age born in Victoria in 2005
    Lex W Doyle
    Newborn Services, Royal Women s Hospital, Melbourne, Australia
    J Pediatr 156:49-53.e1. 2010
    ..To determine the survival rates and neurosensory outcomes of infants born at gestational age 22-27 weeks in the state of Victoria in 2005 and compare theses data with those for similar infants born in the 1990s...
  81. ncbi Randomized trial of a parenting intervention for very preterm infants: outcome at 2 years
    Samantha Johnson
    University of Nottingham, Nottingham, United Kingdom
    J Pediatr 155:488-94. 2009
    ..To determine the efficacy of a neonatal parenting intervention for improving development in very preterm infants...
  82. ncbi Functional impairments at school age of preterm born children with late-onset sepsis
    Meike van der Ree
    Division of Neonatology, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Early Hum Dev 87:821-6. 2011
    ..Late-onset sepsis is a relatively common complication particularly of preterm birth that affects approximately a quarter of very low birth weight infants...
  83. ncbi Developing and refining the Taiwan Birth Cohort Study (TBCS): five years of experience
    For Wey Lung
    Department of Medicine, Kaohsiung Armed Forces General Hospital, Taiwan
    Res Dev Disabil 32:2697-703. 2011
    ..The TBCS will provide ongoing longitudinal information regarding the predisposing and maintaining factors affecting the long term outcome of pediatric illnesses...
  84. ncbi Treatment of epilepsy in children with developmental disabilities
    Dewi Frances T Depositario-Cabacar
    Neurology and Pediatrics, George Washington University Medical Center, Children s National Medical Center, Washington, DC, USA
    Dev Disabil Res Rev 16:239-47. 2010
    Children with developmental disabilities are at increased risk for epilepsy with a prevalence rate higher than the general population...
  85. ncbi Outcome of extremely low birth weight survivors at school age: the influence of perinatal parameters on neurodevelopment
    Achim Peter Neubauer
    Kinderkrankenhaus auf der Bult, Janusz Korczak Allee 12, 30173 Hannover, Germany
    Eur J Pediatr 167:87-95. 2008
    ..Thus, measures to prevent complications such as necrotizing enterocolitis, cerebral haemorrhage, and undernutrition remain important goals for neonatal intensive care...
  86. pmc Sleep problems in children with autism spectrum disorders, developmental delays, and typical development: a population-based study
    Paula Krakowiak
    Division of Epidemiology, Department of Public Health Sciences, School of Medicine, University of California, Davis, CA, USA
    J Sleep Res 17:197-206. 2008
    ..Factor scores for children with DD were intermediate between the ASD and TD groups. Cognitive or adaptive development did not predict severity of sleep problems in the ASD group...
  87. ncbi Access to dental care for persons with developmental disabilities in Ontario
    Anjani Koneru
    College of Dentistry, University of Saskatchewan, Saskatoon, Saskatchewan
    J Can Dent Assoc 75:121. 2009
    This study was undertaken to determine the proportion of persons primarily with developmental disabilities who encounter difficulties accessing dental care in Ontario, to identify perceived barriers to accessing dental care and to ..
  88. pmc Early-childhood neurodevelopmental outcomes are not improving for infants born at <25 weeks' gestational age
    Susan R Hintz
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, 750 Welch Rd, Suite 315, Palo Alto, CA 94304, USA
    Pediatrics 127:62-70. 2011
    ..We compared neurodevelopmental outcomes at 18 to 22 months' corrected age of infants born with extremely low birth weight at an estimated gestational age of <25 weeks during 2 periods: 1999-2001 (epoch 1) and 2002-2004 (epoch 2)...
  89. pmc Association of prenatal maternal or postnatal child environmental tobacco smoke exposure and neurodevelopmental and behavioral problems in children
    B Eskenazi
    Center for Children s Environmental Health Research, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    Environ Health Perspect 107:991-1000. 1999
    ..Although some evidence suggests that maternal smoking during pregnancy may be associated with deficits in intellectual ability and behavioral problems in children, the impact of prenatal or postnatal ETS exposure remains less clear...
  90. ncbi Neurocognitive outcome following fetal growth restriction
    D M Walker
    Academic Division of Child Health, School of Human Development, University of Nottingham, Nottingham, UK
    Arch Dis Child Fetal Neonatal Ed 93:F322-5. 2008
    ..The aim is to clarify the relationship between poor fetal growth and abnormal brain development in order to understand the research directions required to untangle this complex issue...
  91. pmc Clinical and cognitive characteristics of children with attention-deficit hyperactivity disorder, with and without copy number variants
    Kate Langley
    Department of Psychological Medicine and Neurology, and MRC Centre for Neuropsychiatric Genetics, Cardiff University, Cardiff, UK
    Br J Psychiatry 199:398-403. 2011
    ..Submicroscopic, rare chromosomal copy number variants (CNVs) contribute to neurodevelopmental disorders but it is not known whether they define atypical clinical cases...
  92. ncbi Validity of a performance assessment of activities of daily living for people with developmental disabilities
    A Kottorp
    Department of Community Medicine and Rehabilitation, Division of Occupational Therapy, Umea University, Umea, Sweden
    J Intellect Disabil Res 47:597-605. 2003
    Since clients with different types of developmental disabilities often experience difficulties in activities of daily living (ADL), it is critical that assessments of ADL are evaluated in order to ensure that one can make valid judgements ..
  93. ncbi High signal intensity on T2-weighted MR imaging at term-equivalent age in preterm infants does not predict 2-year neurodevelopmental outcomes
    H Kidokoro
    Departments of Pediatrics, Washington University, St Louis, MO, USA
    AJNR Am J Neuroradiol 32:2005-10. 2011
    ..The aim of this study was to examine the relationship between the presence and extent of DEHSI and neurodevelopmental outcomes...
  94. ncbi Epilepsy caused by CDKL5 mutations
    Maija Castrén
    Rinnekoti Foundation, Rinnekodintie 10, FIN 02980 Espoo, Finland
    Eur J Paediatr Neurol 15:65-9. 2011
    ..3 Mb at Xp22.13 including the CDKL5 gene. We review phenotypes associated with CDKL5 mutations and examine putative relationships between the clinical epilepsy phenotype and the type of the mutation in the CDKL5 gene...
  95. ncbi 2q23 de novo microdeletion involving the MBD5 gene in a patient with developmental delay, postnatal microcephaly and distinct facial features
    Brian H Y Chung
    Division of Clinical and Metabolic Genetics, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Med Genet A 155:424-9. 2011
    ..Her speech was dysarthric, and she demonstrated repetitive hand movements. In this article, we compare the clinical features of our patient with previously reported cases with a 2q23.1 deletion...
  96. pmc Phenotypic manifestations of copy number variation in chromosome 16p13.11
    Sandesh C Sreenath Nagamani
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Eur J Hum Genet 19:280-6. 2011
    ..Our findings expand the repertoire of clinical features observed in patients with CNV in 16p13.11 and strengthen the hypothesis that this is a dosage sensitive region with clinical relevance...
  97. doi Benefit of magnesium sulfate given before very preterm birth to protect infant brain
    Stephane Marret
    Pediatrics 121:225-6. 2008
  98. ncbi Impact of seizures on developing dendrites: implications for intellectual developmental disabilities
    Jose R Casanova
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, U S A
    Epilepsia 53:116-24. 2012
    ....
  99. pmc Developmental regression and mitochondrial dysfunction in a child with autism
    Jon S Poling
    Department of Neurology and Neurosurgery, Johns Hopkins Hospital, Baltimore, MD, USA
    J Child Neurol 21:170-2. 2006
    ..These data suggest that further metabolic evaluation is indicated in autistic patients and that defects of oxidative phosphorylation might be prevalent...
  100. ncbi Copy number variations in neurodevelopmental disorders
    Hannah M Grayton
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London SE5 8AF, UK
    Prog Neurobiol 99:81-91. 2012
    ....

Research Grants77

  1. Improving Quality Care for Children with Special Needs:*
    CARMEN LOZZIO; Fiscal Year: 2007
    ..The proposed project will expand the CHP to include children with other genetic disorders and developmental disabilities diagnosed at the major Genetic and Child Development Centers in the state...
  2. Early Identification of Developmental Disorders in Infants
    B Parker; Fiscal Year: 2007
    ..These infants have an increased risk of long-term developmental disabilities, with approximately 5-15% exhibiting major neurodevelopmental disabilities (e.g...
  3. Effects of Testosterone and Genetic Factors on Psychological and Motor Function i
    NICOLE RENEE TARTAGLIA; Fiscal Year: 2013
    ..abnormalities, endocrinology, clinical trials, genotype-phenotype studies, neurogenetic syndromes, developmental disabilities, bioethics, and molecular biology...
  4. Photoperiod Brain and Behavior
    Randy J Nelson; Fiscal Year: 2012
    ..approach will provide insight into the treatment of seasonal cognitive and affective disorders, developmental disabilities, and help establish general mechanisms underlying brain plasticity...
  5. North Carolina Birth Defects Study To Evaluate Pregnancy Exposures (NC BD-STEPS)
    Andrew Olshan; Fiscal Year: 2013
    ..and Prevention (CBDRP) across the nation, funded by the CDC's National Center on Birth Defects and Developmental Disabilities, have collaborated on the National Birth Defects Prevention Study (NBDPS)...
  6. Age-dependent microglial responses in hypoxia-ischemia
    PETER A FERRAZZANO; Fiscal Year: 2013
    ..The location of my lab at the Waisman Center for Developmental Disabilities research is the ideal environment for conducting translational research in developmental brain injuries...
  7. Cardiometabolic Risk Factors and Obesity in Adolescents with Down Syndrome
    Sheela Natesh Magge; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Individuals with intellectual and developmental disabilities are at particular risk for co-morbidities that compromise health and quality of life, but evidence to ..
  8. The Ethics of Fragile X Genetic Screening and Testing Across the Lifespan
    Kruti Acharya; Fiscal Year: 2012
    ..Because of my training in Internal Medicine, Pediatrics, Developmental Disabilities, and Medical Ethics, I am uniquely qualified to pursue this goal and to become an independent ..
  9. MRDD Research Center
    KARL PFENNINGER; Fiscal Year: 2009
    DESCRIPTION [provided by applicant]: The University of Colorado Mental Retardation and Developmental Disabilities Research Center requests support for nine cores (eight previously funded and one proposed) for a comprehensive research ..
  10. Early Identification of Developmental Disorders in Infants
    B Eugene Parker; Fiscal Year: 2012
    ..These infants have an increased risk of long-term developmental disabilities, with 5-15% exhibiting major neurodevelopmental disabilities (e.g...
  11. Kinetics of Chromosome Synapsis During Meiosis
    Jennifer C Fung; Fiscal Year: 2013
    ..tied to human infertility and is also the leading known genetic cause for mental retardation and developmental disabilities. Elucidating the basic mechanisms underlying proper chromosome segregation during meiosis will enable ..
  12. Sensorimotor Control of the Human Orofacial System
    Steven M Barlow; Fiscal Year: 2012
    ..Prematurity is the leading cause of developmental disabilities in children, including cerebral palsy, mental retardation, blindness, chronic lung problems, attention ..
  13. Community-Academic Partnership: Building an Infrastructure to Improve Health for
    Beth A Marks; Fiscal Year: 2010
    ..AHC) partnership to enhance health status and optimize full community participation of people with developmental disabilities (DD) across the lifespan...
  14. PPM-PREP: Peer-Mentored Preparedness for Adults with Developmental Disabilities
    DAVID PAUL EISENMAN; Fiscal Year: 2010
    ..The intervention builds upon studies the partners conducted on disaster preparedness and developmental disabilities. The Principal Investigator developed a disaster preparedness intervention (PREP) and demonstrated its ..
  15. Self-Regulation and Sleep in Children At Risk for Autism Spectrum Disorders
    AMY J SCHWICHTENBERG; Fiscal Year: 2013
    ..position in a department of Psychology or Human Development at a university with an established developmental disabilities center and to launch a research lab that studies a variety of self-regulatory capacities in young ..
  16. Self-Regulation and Sleep in Children At Risk for Autism Spectrum Disorders
    AMY J SCHWICHTENBERG; Fiscal Year: 2012
    ..position in a department of Psychology or Human Development at a university with an established developmental disabilities center and to launch a research lab that studies a variety of self-regulatory capacities in young ..
  17. Effect of Perinatal Nicotine Exposure on the Development of Autonomic Responses
    JANE ELIZABETH BLOOD SIEGFRIED; Fiscal Year: 2010
    ..produces impairment of brainstem and autonomic nervous system function consistent with SIDS and other developmental disabilities. The candidate will use an animal model she developed that accounts for environmental, developmental and ..
  18. Oral Health Intervention for Intellectually/Developmentally Disabled Persons
    KNOWLTON WILLIAM JOHNSON; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): People with intellectual and/or developmental disabilities (IDD) living in family or group homes receive less preventive medical care than those living in institutions and are less likely to receive ..
  19. NEWBORN SCREENING TRANSLATIONAL RESEARCH NETWORK (NBSTRN)
    Michael Watson; Fiscal Year: 2013
    ..Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Intellectual and Developmental Disabilities Branch (IDDB)...
  20. Profiling direct/indirect basal ganglia cells in restricted repetitive behavior
    AMBER M VAN MATRE; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Many people with developmental disabilities, neurological problems, or psychiatric issues show restricted repetitive behaviors...
  21. Age and molecular mechanisms contributing to aneuploidy in oocytes
    Richard M Schultz; Fiscal Year: 2013
    ..is a leading cause of pregnancy loss, and when development goes to term, an aggravating source of developmental disabilities and mental retardation...
  22. Colorado CADDRE Study to Explore Early Development CADDRE_SEED II
    Cordelia Robinson; Fiscal Year: 2013
    ..and research programs that address the magnitude, incidence, and causes of autism and related developmental disabilities. The Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDREs) were ..
  23. NC CADDRE: Study to Explore Early Development (SEED) Phase II
    Julie L Daniels; Fiscal Year: 2013
    ..and research programs that address the magnitude, incidence, and causes of autism and related developmental disabilities. The Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDREs) were ..
  24. MD CADDRE: Study to Explore Early Development, SEED Phase II
    Margaret Daniele Fallin; Fiscal Year: 2013
    ..and research programs that address the magnitude, incidence, and causes of autism and related developmental disabilities. The Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDREs) were ..
  25. The North Carolina Cleft Outcomes Study
    Ronald P Strauss; Fiscal Year: 2013
    ..The survey will include questions about academic achievement, maternal bonding, family impact, developmental disabilities, experiences with team care, surgical procedures, satisfaction with surgery, and caregiver and out-of-..
  26. Regulation Of Cortical Neurogenesis By Apical Complex Proteins
    Seonhee Kim; Fiscal Year: 2013
    ..process does not occur properly, abnormalities in the cortical structure are a result, often leading to developmental disabilities such as mental retardation, epilepsy, and autism...
  27. ISOLATION AND CHARACTERIZATION OF SYNAPTOGENIC PROTEINS
    JUAN L BRUSES; Fiscal Year: 2011
    ..and become affected in a variety of mental and neurological disorders including, intellectual developmental disabilities, autism, and schizophrenia...
  28. Integrated EEG/NIR Sensor System for Infants
    Catherine Poulsen; Fiscal Year: 2013
    ..of immediate at-risk neonates, and early identification and intervention for abnormalities that predict developmental disabilities and cognitive deficits...
  29. 2012 Meiosis Gordon Research Conference and Gordon Research Seminar
    Nancy M Hollingsworth; Fiscal Year: 2012
    ..abnormal numbers of chromosomes that in turn can result in spontaneous abortions or individuals with developmental disabilities. This meeting will provide a forum for discussions that advance knowledge of reproductive health, and ..
  30. Late adverse Impact of Getting Hyperbilrubinemia or photo Therapy (LIGHT) study
    Thomas B Newman; Fiscal Year: 2013
    ..medical records and the California Department of Developmental Services database of children with developmental disabilities, with confirmatory case review by a child neurologist or audiologist...
  31. Portion control lifestyle change to decrease obesity in persons with disabilities
    Mary E Segal; Fiscal Year: 2012
    ..cues for healthy nutrition and decreased caloric intake to reduce obesity and overweight in persons with developmental disabilities (DD) who live in community group homes with care provider staff...
  32. Oral Health Status and its Correlates in Adults with Developmental Disabilities
    JOHN PATRICK contact MORGAN; Fiscal Year: 2010
    ..disabled, the oral health status, treatment needs and helpful interventions for adults with developmental disabilities (DD) are largely unknown...
  33. N-acetylglutamate Synthase: Structure, Function &Defects
    Mendel Tuchman; Fiscal Year: 2012
    ..organic acidemias and valproate treatment causes hyperammonemia that frequently leads to brain damage, developmental disabilities and death...
  34. Transfusion-Associated Brain Improvement (TABI) Trial: Data Coordinating Center
    Abhik Das; Fiscal Year: 2013
    ..Long-term outcomes of survivors often include neuro- developmental disabilities. In surviving Extremely Low Birth Weight (ELBW) babies born at less than 1000 g BW, 47% had low ..
  35. MRI and Neuropsychological Findings in Schizophrenia, ADHD and Healthy Controls
    MARTHA ELIZABETH SHENTON; Fiscal Year: 2010
    ..in collaboration with the ICOHRTA Research Training Program in International Mental Health &Developmental Disabilities (MH/DD) at the Children's Hospital Boston (Dr...
  36. Data Coordinating Center for Autism &Other Developmental Disabilities: SEED I&II
    Philip L Reed; Fiscal Year: 2013
    ..and U01/DD000498 that established a Data Coordinating Center (DCC) for the Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE) at Michigan State University (MSU)...
  37. Development of an Epigenetic Biomarker for Prediction of Fetal Alcohol Spectrum D
    AILEEN ESTELLE BALDWIN; Fiscal Year: 2013
    ..brain is most vulnerable to teratogens, to predict those at risk for developing the neurobehavioral and developmental disabilities associated with FASD...
  38. FORMATION, STRUCTURE AND FUNCTION IN HETEROCHROMATIN
    Sarah C R Elgin; Fiscal Year: 2011
    ..and is a contributing factor in many health problems, including cancer and genetically-based developmental disabilities. Heterochromatin packaging can be perpetuated and spread by virtue of an interacting set of structural ..
  39. Exploring the Neuronal Phenotype of Autism Spectrum Disorders Using Induced Pluri
    JOACHIM F contact HALLMAYER; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Autism is considered to be among the most common of the serious developmental disabilities, second only to mental retardation. The lifetime per capita incremental societal cost is estimated at $3...
  40. Research Training in Intellectual Disabilities
    John G Borkowski; Fiscal Year: 2010
    ..2010 for what we believe has become a highly successful research training program in mental retardation/developmental disabilities (MR/DD)...
  41. Regulation of the DNA damage response by ATM-MRN pathway
    Jean Gautier; Fiscal Year: 2013
    ..DSBs properly is associated with cancer development, radiation sensitivity, immune deficiencies, and developmental disabilities. We hypothesize that the proteins recruited at DSBs - the DSB proteome - dictate the DNA damage response,..
  42. Recombination rate variation and evolution in primates
    MOLLY F PRZEWORSKI; Fiscal Year: 2013
    ..recombination process lead to aneuploidy, the leading cause of spontaneous miscarriages and of severe developmental disabilities, as well as to deleterious genome rearrangements and possibly to mutations...
  43. Intellectual and Developmental Disabilities Research Centers
    Jean de Vellis; Fiscal Year: 2013
    ..is for continued support of the administrative and research cores of the UCLA Intellectual and Developmental Disabilities Research Center (IDDRC)...
  44. Brainstem GABAergic Neuron Development and Function
    Russell S Ray; Fiscal Year: 2012
    ..cause of post-neonatal infant mortality in the United States, and Rett syndrome - the leading cause of developmental disabilities in young girls...
  45. Arizona Surveillance and Research Center for Developmental Disabilities
    Sydney A Rice; Fiscal Year: 2011
    ..Gather data and information using a combination of methods, including interviews, survey, records abstraction, and neuropsychological testing.5. Assess the effectiveness of data collection methods.6. Assess the outcomes of the project. ..
  46. Acquisition of Zeiss Cell Observer Spinning Disk Confocal System
    Anastas Popratiloff; Fiscal Year: 2012
    ..Analysis (CMIA), and made available to members of NIH-funded Centers, including the Intellectual and Developmental Disabilities Research Center (IDDRC) at the GW-affiliated Children's National Medical Center and the District of ..
  47. Mental Health/Disabilities(MHDD)Research Education Program
    Kerim M Munir; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Developmental programs and University Center for Excellence in Developmental Disabilities (UCEDD) at Children's Hospital Boston and STAART/Autism Center for Excellence at Boston University (BU), ..
  48. 2012 Teratology Society Annual Meeting - Student/New and Early Stage Investigator
    JOHN MATTHEWSON GRAHAM; Fiscal Year: 2012
    ..health scientists who investigate the causes and biological processes leading to birth defects and developmental disabilities. Committed to the support, encouragement, and training of students and new and early stage investigators,..
  49. The Relationship Between State EPSDT Policies, Well-Child Care and Age of Autism
    AMY MARIE DANIELS; Fiscal Year: 2011
    ..through which policies affect health practice and contribute to improved outcomes for children with developmental disabilities such as autism...
  50. Interdisciplinary Research Training in Speech-Language Disorders
    SUSAN ELLIS-WEISMER; Fiscal Year: 2012
    ..of the Waisman Center, an inter-disciplinary center that supports research on human development, developmental disabilities, and neurodegenerative diseases...
  51. Radiofrequency Transmit and Receive Upgrade for 3T Research Scanner
    Peter van Zijl; Fiscal Year: 2009
    ..and spectroscopic imaging (MRSI), and diffusion tensor imaging (DTI) of a large range of diseases and developmental disabilities. This proposed instrumentation will provide the following benefits: 1) Body coil TX /Release 3...
  52. Urea Cycle Disorders Satellite Symposium: 11th International Meeting
    BRENDAN HL LEE; Fiscal Year: 2012
    ..of Psychiatry and Pediatrics and Associate Director for Clinical Research, UCLA Intellectual and Developmental Disabilities Research Center, and Brendan Lee, M.D., Ph.D...
  53. Baylor Intellectual and Developmental Disabilities Research Center
    Huda Y Zoghbi; Fiscal Year: 2013
    The Baylor College of Medicine (BCM) Intellectual and Developmental Disabilities Research Center (IDDRC) was established on August 1, 1988 and has been continuously funded with the last renewal of funding dated July 1, 2004...
  54. Neuroprotection from hyperammonemia: small molecule screen
    Mendel Tuchman; Fiscal Year: 2013
    ..catabolic stress can be life threatening and can cause severe brain damage resulting in intellectual and developmental disabilities. Available therapies are mainly targeted at reducing blood ammonia levels and although they can fervent ..
  55. North Carolina Ctr for Autism & Development Disabilities Research & Epidemiology
    Julie L Daniels; Fiscal Year: 2010
    ..The Centers for Autism and Developmental Disabilities Research and Epidemiology were established in 2001 to investigate causes and correlates of autism...
  56. National CADDRE Study: Child Development and Autism
    Lisa A Croen; Fiscal Year: 2010
    ..The Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE) were established in 2001 to investigate causes and correlates of ..
  57. Centers for Autism & Develop Disabilities Resarch & Epidemiol:A Case-Cohort Study
    Margaret Daniele Fallin; Fiscal Year: 2010
    ..The Centers for Autism and Developmental Disabilities Research and Epidemiology were established in 2001 to investigate causes and correlates of autism...
  58. Mental Retardation and Developmental Disabilities Research Centers 2008
    Michael F Cataldo; Fiscal Year: 2013
    This application for continued support of Years 21 through 25 of the Mental Retardation and Developmental Disabilities Research Center (MRDDRC) at the Kennedy Krieger Institute and Johns Hopkins University is submitted in response to RFA-..
  59. Behavioral Intervention in Autism: Practitioner Skills
    Charles Hamad; Fiscal Year: 2010
    ..Whereas all children with developmental disabilities receive some form of federally mandated Early Intervention, demands are being placed on parents and ..
  60. UAB Mental Retardation Research Center
    ALAN KENNETH PERCY; Fiscal Year: 2012
    ..the University's contributions over the past three decades to the field of mental retardation and developmental disabilities. The MRRC's mission is threefold: to increase scientific knowledge about basic developmental ..
  61. DEFINITION AND DEVELOPMENT OF THE PHENOTYPE IN AUTISM
    Sally Rogers; Fiscal Year: 2001
    ..control families (Project 0002) 2) 40 adults with idiopathic autism, 40 adults with FXS, 40 adults with developmental disabilities (DD) but neither autism nor FXS, and 40 CA and 30 MA controls (Project 0001); and 3) 25 very young ..
  62. Integrated EEG/NIR Sensor System for Infants
    Catherine Poulsen; Fiscal Year: 2009
    ..of immediate at-risk neonates, and early identification and intervention for abnormalities that predict developmental disabilities and cognitive deficits...
  63. RETIREMENT,LEISURE & OLD ADULTS--DEVELOPMENT DISABILITIE
    Martin Sheehan; Fiscal Year: 2000
    Now that a significant number of people with developmental disabilities are reaching the later stage in life, service providers are faced with new challenges...
  64. Health promotion: persons with disabilities partner with the academy
    Mary Segal; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Health promotion: persons with developmental disabilities partner with the academy This study explores an innovative method to increase understanding of health care research and to develop strategies ..
  65. Efficacy of Various Positive Reinforcers in the Treatment of Destructive Behavior
    HENRY ROANE; Fiscal Year: 2010
    ..In this investigation, individuals with developmental disabilities will select their preferred items through a commonly used preference assessment...
  66. MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES
    ROBERT DESNICK; Fiscal Year: 2007
    ..revised application is designed to continue and expand the training program in mental retardation and developmental disabilities (MRDD) at Mount Sinai School of Medicine...
  67. LANGUAGE AND DEVELOPMENTAL DISABILITIES IN CHILDREN
    Carl Feinstein; Fiscal Year: 1993
    ..seeks a two year extension of the Child and Adolescent Mental Health Academic Award: Language and Developmental Disabilities in Children, for Carl Feinstein MD, Medical Director of the Developmental Disabilities Program at ..
  68. Rehabilitation Research & Training Center on Aging with Development Disabilities
    Tamar Heller; Fiscal Year: 2007
    unreadable] DESCRIPTION (Provided by Applicant): The conference "State of the Science in Aging with Developmental Disabilities: Charting Lifespan Trajectories and Supportive Environments for Healthy Community Living" is sponsored by the ..
  69. TRAINING DIRECT CARE STAFF TO SUPPORT SELF-DETERMINATION
    ELIZABETH THORIN; Fiscal Year: 2000
    Principles of self-determination form the core of a new model of supports for adults who have developmental disabilities. Adults who have disabilities often rely on others for ongoing assistance in the activities of daily living...
  70. California Monitoring of Early Childhood Autism (CA-MECA)
    Gayle C Windham; Fiscal Year: 2010
    ..Doing so is relevant to CDC's goal to prevent birth defects and developmental disabilities and improve the health of people with disabilities...
  71. Web-Based Intervention for Alcohol Use in Women of Childbearing Potential
    KATIA HOWLETT; Fiscal Year: 2009
    ..Spectrum Disorders (FASDs), resulting from prenatal exposure to alcohol, are among the most common developmental disabilities, occurring in as many as 1 in 100 children in the U.S...
  72. Parenting Your Young Child with Autism: A Web-Based Tutorial
    Kenneth Kobak; Fiscal Year: 2010
    ..It is among the most prevalent of all developmental disabilities, with an estimated prevalence of 1 in 150...
  73. NOVEL ANTIPSYCHOTICS AND STEREOTYPED MOVEMENT DISORDER
    Karl Newell; Fiscal Year: 2007
    ..the most frequently used medication treatment for behavioral and psychiatric disorders associated with developmental disabilities. The atypical antipsychotics are purported to have both a lower risk of antipsychotic-induced side ..