attention deficit disorder with hyperactivity

Summary

Summary: A behavior disorder originating in childhood in which the essential features are signs of developmentally inappropriate inattention, impulsivity, and hyperactivity. Although most individuals have symptoms of both inattention and hyperactivity-impulsivity, one or the other pattern may be predominant. The disorder is more frequent in males than females. Onset is in childhood. Symptoms often attenuate during late adolescence although a minority experience the full complement of symptoms into mid-adulthood. (From DSM-IV)

Top Publications

  1. ncbi Attention-deficit hyperactivity disorder
    Joseph Biederman
    Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Lancet 366:237-48. 2005
  2. ncbi The worldwide prevalence of ADHD: a systematic review and metaregression analysis
    Guilherme Polanczyk
    ADHD Outpatient Program, Child and Adolescent Psychiatric Division, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos, 2350, Porto Alegre, RS, Brazil 90035 003
    Am J Psychiatry 164:942-8. 2007
  3. ncbi Psychometric properties of the strengths and difficulties questionnaire
    R Goodman
    Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Kings College London, England
    J Am Acad Child Adolesc Psychiatry 40:1337-45. 2001
  4. ncbi Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD
    R A Barkley
    Department of Psychiatry, University of Massachusetts Medical Center, Worcester 01655, USA
    Psychol Bull 121:65-94. 1997
  5. ncbi The ESSENCE in child psychiatry: Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations
    Christopher Gillberg
    Institute of Neuroscience and Physiology, Child and Adolescent Psychiatry, University of Goteborg, Sweden
    Res Dev Disabil 31:1543-51. 2010
  6. ncbi The genetics of autism spectrum disorders and related neuropsychiatric disorders in childhood
    Paul Lichtenstein
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Am J Psychiatry 167:1357-63. 2010
  7. pmc Cingulate-precuneus interactions: a new locus of dysfunction in adult attention-deficit/hyperactivity disorder
    F Xavier Castellanos
    Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, New York University Child Study Center, New York, NY 10016, USA
    Biol Psychiatry 63:332-7. 2008
  8. ncbi Prevalence and correlates of adult attention-deficit hyperactivity disorder: meta-analysis
    Viktoria Simon
    Semmelweis University Budapest, Department of Psychiatry and Psychotherapy, Balassa u 6, Budapest H 1083, Hungary
    Br J Psychiatry 194:204-11. 2009
  9. pmc Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis
    Nigel M Williams
    MRC Centre in Neuropsychiatric Genetics and Genomics and Department of Psychological Medicine and Neurology, Cardiff University School of Medicine, Cardiff, UK
    Lancet 376:1401-8. 2010
  10. ncbi The age-dependent decline of attention deficit hyperactivity disorder: a meta-analysis of follow-up studies
    Stephen V Faraone
    Medical Genetics Research Program and Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Psychol Med 36:159-65. 2006

Detail Information

Publications298 found, 100 shown here

  1. ncbi Attention-deficit hyperactivity disorder
    Joseph Biederman
    Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Lancet 366:237-48. 2005
    ..Other investigations have also clarified the appropriate role of targeted psychosocial treatments in the context of ongoing pharmacotherapy...
  2. ncbi The worldwide prevalence of ADHD: a systematic review and metaregression analysis
    Guilherme Polanczyk
    ADHD Outpatient Program, Child and Adolescent Psychiatric Division, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos, 2350, Porto Alegre, RS, Brazil 90035 003
    Am J Psychiatry 164:942-8. 2007
    ..Presently, the reasons for this discrepancy remain poorly understood. The purpose of this study was to determine the possible causes of the varied worldwide estimates of the disorder and to compute its worldwide-pooled prevalence...
  3. ncbi Psychometric properties of the strengths and difficulties questionnaire
    R Goodman
    Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Kings College London, England
    J Am Acad Child Adolesc Psychiatry 40:1337-45. 2001
    ..To describe the psychometric properties of the Strengths and Difficulties Questionnaire (SDQ), a brief measure of the prosocial behavior and psychopathology of 3-16-year-olds that can be completed by parents, teachers, or youths...
  4. ncbi Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD
    R A Barkley
    Department of Psychiatry, University of Massachusetts Medical Center, Worcester 01655, USA
    Psychol Bull 121:65-94. 1997
    ..Although the model is promising as a potential theory of self-control and ADHD, far more research is required to evaluate its merits and the many predictions it makes about ADHD...
  5. ncbi The ESSENCE in child psychiatry: Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations
    Christopher Gillberg
    Institute of Neuroscience and Physiology, Child and Adolescent Psychiatry, University of Goteborg, Sweden
    Res Dev Disabil 31:1543-51. 2010
    ..There is no time to wait; something needs to be done, and that something is unlikely to be just in the area of speech and language, just in the area of autism or just in special education...
  6. ncbi The genetics of autism spectrum disorders and related neuropsychiatric disorders in childhood
    Paul Lichtenstein
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Am J Psychiatry 167:1357-63. 2010
    ..Population-based studies of the heritability of other neuropsychiatric disorders and comorbidities among them have also been sparse. The authors sought to address both of these issues...
  7. pmc Cingulate-precuneus interactions: a new locus of dysfunction in adult attention-deficit/hyperactivity disorder
    F Xavier Castellanos
    Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, New York University Child Study Center, New York, NY 10016, USA
    Biol Psychiatry 63:332-7. 2008
    ....
  8. ncbi Prevalence and correlates of adult attention-deficit hyperactivity disorder: meta-analysis
    Viktoria Simon
    Semmelweis University Budapest, Department of Psychiatry and Psychotherapy, Balassa u 6, Budapest H 1083, Hungary
    Br J Psychiatry 194:204-11. 2009
    ..In spite of the growing literature about adult attention-deficit hyperactivity disorder (ADHD), relatively little is known about the prevalence and correlates of this disorder...
  9. pmc Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis
    Nigel M Williams
    MRC Centre in Neuropsychiatric Genetics and Genomics and Department of Psychological Medicine and Neurology, Cardiff University School of Medicine, Cardiff, UK
    Lancet 376:1401-8. 2010
    ..We aimed to establish whether burden of CNVs was increased in ADHD, and to investigate whether identified CNVs were enriched for loci previously identified in autism and schizophrenia...
  10. ncbi The age-dependent decline of attention deficit hyperactivity disorder: a meta-analysis of follow-up studies
    Stephen V Faraone
    Medical Genetics Research Program and Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Psychol Med 36:159-65. 2006
    ..This study examined the persistence of attention deficit hyperactivity disorder (ADHD) into adulthood...
  11. ncbi Computerized training of working memory in children with ADHD--a randomized, controlled trial
    Torkel Klingberg
    Unit of Neuropediatrics, Department Women and Children s Health, Karolinska Institute, 17176 Stockholm, Sweden
    J Am Acad Child Adolesc Psychiatry 44:177-86. 2005
    ..During 2002 to 2003, the authors conducted a multicenter, randomized, controlled, double-blind trial to investigate the effect of improving WM by computerized, systematic practice of WM tasks...
  12. ncbi Cognitive and behavioral outcomes of school-aged children who were born preterm: a meta-analysis
    Adnan T Bhutta
    Department of Pediatrics, Arkansas University for Medical Sciences, Little Rock, USA
    JAMA 288:728-37. 2002
    ..The cognitive and behavioral outcomes of school-aged children who were born preterm have been reported extensively. Many of these studies have methodological flaws that preclude an accurate estimate of the long-term outcomes of prematurity...
  13. pmc Rare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genes
    J Elia
    Department of Child and Adolescent Psychiatry, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Mol Psychiatry 15:637-46. 2010
    ..Together, these results suggest that rare inherited structural variations play an important role in ADHD development and indicate a set of putative candidate genes for further study in the etiology of ADHD...
  14. pmc Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation
    P Shaw
    Child Psychiatry Branch, National Institute of Mental Health, Room 3N202, Building 10, Center Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:19649-54. 2007
    ..Neuroanatomic documentation of a delay in regional cortical maturation in ADHD has not been previously reported...
  15. ncbi Gray matter volume abnormalities in ADHD: voxel-based meta-analysis exploring the effects of age and stimulant medication
    Tomohiro Nakao
    Institute of Psychiatry, King s College London, UK
    Am J Psychiatry 168:1154-63. 2011
    ..The authors conducted a meta-analysis of voxel-based morphometry studies in children and adults with ADHD and examined the potential effects of age and stimulant medication on regional gray matter volumes...
  16. ncbi Meta-analysis of neurobehavioral outcomes in very preterm and/or very low birth weight children
    Cornelieke Sandrine Hanan Aarnoudse-Moens
    Division of Neonatology, Department of Pediatrics, Erasmus University Medical Centre Sophia Children s Hospital, Rotterdam, Netherlands
    Pediatrics 124:717-28. 2009
    ..We conducted a quantitative meta-analysis of studies published between 1998 and 2008 on academic achievement, behavioral functioning, and EF with the aim of providing aggregated measures of effect size for these outcome domains...
  17. ncbi Validity of the executive function theory of attention-deficit/hyperactivity disorder: a meta-analytic review
    Erik G Willcutt
    Department of Psychology, University of Colorado, Boulder, Colorado 80309, USA
    Biol Psychiatry 57:1336-46. 2005
    ..Difficulties with EF appear to be one important component of the complex neuropsychology of ADHD...
  18. pmc Investigating the contribution of common genetic variants to the risk and pathogenesis of ADHD
    Evangelia Stergiakouli
    MRC Centre in Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, Wales
    Am J Psychiatry 169:186-94. 2012
    ..The authors undertook a GWAS of ADHD and examined whether associated SNPs, including those below conventional levels of significance, influenced the same biological pathways affected by CNVs...
  19. ncbi Candidate gene studies of ADHD: a meta-analytic review
    Ian R Gizer
    Department of Genetics, University of North Carolina at Chapel Hill, 120 Mason Farm Road, Room 5015 Genetic Medicine Building CB 7264, Chapel Hill, NC 27599 7264, USA
    Hum Genet 126:51-90. 2009
    ..g., ADHD subtype diagnoses, gender, exposure to environmental risk factors). We conclude with a discussion of these findings in relation to emerging themes relevant to future studies of the genetics of ADHD...
  20. pmc Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3
    Nigel M Williams
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, and School of Medicine, Cardiff University, Cardiff, UK
    Am J Psychiatry 169:195-204. 2012
    ..Because of its multifactorial etiology, however, identifying the genes involved has been difficult. The authors followed up on recent findings suggesting that rare copy number variants (CNVs) may be important for ADHD etiology...
  21. pmc European consensus statement on diagnosis and treatment of adult ADHD: The European Network Adult ADHD
    Sandra J J Kooij
    PsyQ, psycho medische programma s, Department Adult ADHD, Carel Reinierszkade 197, Den Haag, The Netherlands
    BMC Psychiatry 10:67. 2010
    ..The evidence on persistence poses several difficulties for adult psychiatry considering the lack of expertise for diagnostic assessment, limited treatment options and patient facilities across Europe...
  22. ncbi Cross-national prevalence and correlates of adult attention-deficit hyperactivity disorder
    J Fayyad
    Department of Psychiatry and Clinical Psychology, St George Hospital University Medical Centre, PO Box 166378, Beirut Achrafieh 1100 2807, Lebanon
    Br J Psychiatry 190:402-9. 2007
    ..Little is known about the epidemiology of adult attention-deficit hyperactivity disorder (ADHD)...
  23. ncbi Psychiatric disorders in children with autism spectrum disorders: prevalence, comorbidity, and associated factors in a population-derived sample
    Emily Simonoff
    Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    J Am Acad Child Adolesc Psychiatry 47:921-9. 2008
    ..We identify the rates and type of psychiatric comorbidity associated with ASDs and explore the associations with variables identified as risk factors for child psychiatric disorders...
  24. ncbi The World Health Organization Adult ADHD Self-Report Scale (ASRS): a short screening scale for use in the general population
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    Psychol Med 35:245-56. 2005
    ..The current report presents data on concordance of the ASRS and of a short-form ASRS screener with blind clinical diagnoses in a community sample...
  25. ncbi Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies
    Klaus Peter Lesch
    ADHD Clinical Research Program, Molecular and Clinical Psychobiology, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080, Wuerzburg, Germany
    J Neural Transm 115:1573-85. 2008
    ..g., CDH13, ASTN2) and regulators of synaptic plasticity (e.g., CTNNA2, KALRN) despite the complex multifactorial etiologies of adult ADHD and addiction vulnerability...
  26. ncbi Training of working memory in children with ADHD
    Torkel Klingberg
    Department of Neuropediatrics, Karolinska Institute, Stockholm, Sweden
    J Clin Exp Neuropsychol 24:781-91. 2002
    ..The results thus suggest that WM training potentially could be of clinical use for ameliorating the symptoms in ADHD...
  27. pmc Behavioral models of impulsivity in relation to ADHD: translation between clinical and preclinical studies
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, CB2 3EB, UK
    Clin Psychol Rev 26:379-95. 2006
    ....
  28. pmc Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder
    Nanda N J Rommelse
    Department of Psychiatry, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Center, Reinier Postlaan 10, Nijmegen, The Netherlands
    Eur Child Adolesc Psychiatry 19:281-95. 2010
    ..Multivariate multi-level models are probably best suited for the statistical analysis...
  29. ncbi Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder
    Frank P Bymaster
    Neuroscience Research Division, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Neuropsychopharmacology 27:699-711. 2002
    ..In contrast to methylphenidate, atomoxetine did not increase DA in striatum or nucleus accumbens, suggesting it would not have motoric or drug abuse liabilities...
  30. pmc The epidemiology of pharmacologically treated attention deficit hyperactivity disorder (ADHD) in children, adolescents and adults in UK primary care
    Suzanne McCarthy
    School of Pharmacy, University College Cork, Cork, Ireland
    BMC Pediatr 12:78. 2012
    ..The aim of this study was to investigate the annual prevalence and incidence of pharmacologically treated ADHD in children, adolescents and adults in UK primary care...
  31. ncbi The roles of dopamine and noradrenaline in the pathophysiology and treatment of attention-deficit/hyperactivity disorder
    Natalia Del Campo
    Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    Biol Psychiatry 69:e145-57. 2011
    ....
  32. ncbi ADHD drugs and serious cardiovascular events in children and young adults
    William O Cooper
    Division of General Pediatrics, Vanderbilt University, Nashville, TN 37232 4313, USA
    N Engl J Med 365:1896-904. 2011
    ..Adverse-event reports from North America have raised concern that the use of drugs for attention deficit-hyperactivity disorder (ADHD) increases the risk of serious cardiovascular events...
  33. ncbi Integrated genome-wide association study findings: identification of a neurodevelopmental network for attention deficit hyperactivity disorder
    Geert Poelmans
    Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, The Netherlands
    Am J Psychiatry 168:365-77. 2011
    ..In the present study, the authors investigated the presence of genomic convergence in the top findings of the five published genome-wide association studies (GWASs) of ADHD...
  34. pmc Randomized, double-blind, placebo-controlled, crossover study of the efficacy and safety of lisdexamfetamine dimesylate in adults with attention-deficit/hyperactivity disorder: novel findings using a simulated adult workplace environment design
    Timothy Wigal
    Department of Pediatrics, University of California, Irvine, Child Development Center, Irvine, CA, USA
    Behav Brain Funct 6:34. 2010
    ..Duration of efficacy and safety of lisdexamfetamine dimesylate (LDX) was assessed in adults (18-55 years) with attention-deficit/hyperactivity disorder (ADHD) using the simulated adult workplace environment...
  35. ncbi Maternal lifestyle factors in pregnancy risk of attention deficit hyperactivity disorder and associated behaviors: review of the current evidence
    Karen Markussen Linnet
    Perinatal Epidemiological Research Unit, Department of Obstetrics and Gynecology, the Psychiatric Hospital for Children and Adolescent, Skejby, Denmark
    Am J Psychiatry 160:1028-40. 2003
    ....
  36. ncbi Meta-analysis of structural imaging findings in attention-deficit/hyperactivity disorder
    Eve M Valera
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 61:1361-9. 2007
    ..Our goal was to statistically analyze structural imaging data via a meta-analysis to help resolve these issues...
  37. ncbi The neural correlates of attention deficit hyperactivity disorder: an ALE meta-analysis
    Steven G Dickstein
    NYU Child Study Center, New York, NY 10016, USA
    J Child Psychol Psychiatry 47:1051-62. 2006
    ..The present work provides an objective, unbiased statistically-based meta-analysis of published functional neuroimaging studies of ADHD...
  38. ncbi How specific are executive functioning deficits in attention deficit hyperactivity disorder and autism?
    Hilde M Geurts
    Department of Clinical Neuropsychology, Vrije Universiteit Amsterdam, The Netherlands
    J Child Psychol Psychiatry 45:836-54. 2004
    ..The objective of this study is to identify intact and deficient cognitive processes in children with attention deficit hyperactivity disorder (ADHD) and children with high functioning autism (HFA)...
  39. ncbi Pharmacokinetics of lisdexamfetamine dimesylate and its active metabolite, d-amphetamine, with increasing oral doses of lisdexamfetamine dimesylate in children with attention-deficit/hyperactivity disorder: a single-dose, randomized, open-label, crossover
    Samuel W Boellner
    Clinical Study Centers, Little Rock, Arkansas, USA
    Clin Ther 32:252-64. 2010
    ..Information on the pharmacokinetic profile of LDX in children with ADHD is lacking...
  40. ncbi Prevalence of attention-deficit hyperactivity disorder in substance use disorder patients: a meta-analysis and meta-regression analysis
    Katelijne van Emmerik-van Oortmerssen
    Arkin Mental Health and Addiction Treatment Centre, Amsterdam, The Netherlands
    Drug Alcohol Depend 122:11-9. 2012
    ..Attention deficit hyperactivity disorder (ADHD) is a comorbid condition associated with both onset and prognosis of SUD. Prevalence estimates of ADHD in SUD vary significantly...
  41. ncbi Efficacy of methylphenidate for adults with attention-deficit hyperactivity disorder: a meta-regression analysis
    Xavier Castells
    Psychiatry Department, Hospital Universitari Vall dHebron, Barcelona, Spain
    CNS Drugs 25:157-69. 2011
    ..The reasons for this variability have not been comprehensively investigated...
  42. ncbi "Cool" inferior frontostriatal dysfunction in attention-deficit/hyperactivity disorder versus "hot" ventromedial orbitofrontal-limbic dysfunction in conduct disorder: a review
    Katya Rubia
    Department of Child Psychiatry Medical Research Council Center for Social, Genetic and Developmental Psychiatry, Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 69:e69-87. 2011
    ..There is, hence, evidence for dissociated underlying pathophysiologies for these two disorders that may have implications for future anatomy-based differential diagnosis and prevention and intervention...
  43. ncbi Lisdexamfetamine dimesylate: linear dose-proportionality, low intersubject and intrasubject variability, and safety in an open-label single-dose pharmacokinetic study in healthy adult volunteers
    James Ermer
    Shire Development, 725 Chesterbrook Blvd, Wayne, PA 19087, USA
    J Clin Pharmacol 50:1001-10. 2010
    ..These findings indicate that the pharmacokinetic parameters of d-amphetamine were dose-proportional and predictable over a wide range of lisdexamfetamine dimesylate doses...
  44. ncbi Evidence for overlapping genetic influences on autistic and ADHD behaviours in a community twin sample
    Angelica Ronald
    Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    J Child Psychol Psychiatry 49:535-42. 2008
    ..This study takes an individual differences approach to determine the degree of phenotypic and aetiological overlap between autistic traits and ADHD behaviours in the general population...
  45. pmc A systematic review and analysis of long-term outcomes in attention deficit hyperactivity disorder: effects of treatment and non-treatment
    Monica Shaw
    Clinical Development and Medical Affairs, Shire Pharmaceuticals, Ltd, Basingstoke, UK
    BMC Med 10:99. 2012
    ....
  46. ncbi Efficacy and safety of lisdexamfetamine dimesylate in adolescents with attention-deficit/hyperactivity disorder
    Robert L Findling
    University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA
    J Am Acad Child Adolesc Psychiatry 50:395-405. 2011
    ..To examine lisdexamfetamine dimesylate (LDX) efficacy and safety versus placebo in adolescents with attention-deficit/hyperactivity disorder (ADHD)...
  47. ncbi The estimated prevalence and correlates of adult ADHD in a German community sample
    Martina de Zwaan
    Department of Psychosomatic Medicine and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Eur Arch Psychiatry Clin Neurosci 262:79-86. 2012
    ..ADHD is a common disorder of adulthood, is associated with significant social impairment and psychiatric co-morbidity, and should receive further research attention...
  48. ncbi A review on cognitive and brain endophenotypes that may be common in autism spectrum disorder and attention-deficit/hyperactivity disorder and facilitate the search for pleiotropic genes
    Nanda N J Rommelse
    Department of Psychiatry, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Neurosci Biobehav Rev 35:1363-96. 2011
    ..By specifying the most promising endophenotypic measures we chart the future course for endophenotypic research in ASD and ADHD. We also discuss the various models that may explain the frequent co-occurrence of ASD and ADHD...
  49. ncbi Genome-wide copy number variation analysis in attention-deficit/hyperactivity disorder: association with neuropeptide Y gene dosage in an extended pedigree
    K P Lesch
    ADHD Clinical Research Network, Unit for Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Mol Psychiatry 16:491-503. 2011
    ..These findings implicate CNVs of behaviour-related genes in the pathogenesis of ADHD and are consistent with the notion that both frequent and rare variants influence the development of this common multifactorial syndrome...
  50. pmc Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder
    Benjamin M Neale
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA
    J Am Acad Child Adolesc Psychiatry 49:884-97. 2010
    ..As prior genome-wide association studies (GWAS) have not yielded significant results, we conducted a meta-analysis of existing studies to boost statistical power...
  51. ncbi Methylphenidate normalises activation and functional connectivity deficits in attention and motivation networks in medication-naïve children with ADHD during a rewarded continuous performance task
    Katya Rubia
    Department of Child Psychiatry, Institute of Psychiatry, King s College, London, UK
    Neuropharmacology 57:640-52. 2009
    ..We used functional magnetic resonance imaging (fMRI) to investigate the effects of MPH in medication-naïve children with ADHD on the activation and functional connectivity of "cool" attentional as well as "hot" motivation networks...
  52. pmc Organophosphate pesticide exposure and attention in young Mexican-American children: the CHAMACOS study
    Amy R Marks
    Center for Children s Environmental Health Research, School of Public Health, University of California, Berkeley, Berkeley, California 94720, USA
    Environ Health Perspect 118:1768-74. 2010
    ..Exposure to organophosphate (OP) pesticides, well-known neurotoxicants, has been associated with neurobehavioral deficits in children...
  53. ncbi Double-blind, placebo-controlled study of the efficacy and safety of lisdexamfetamine dimesylate in adults with attention-deficit/hyperactivity disorder
    Lenard A Adler
    Department of Psychiatry, New York University School of Medicine, 530 First Ave 7D, New York, NY 10016, USA
    J Clin Psychiatry 69:1364-73. 2008
    ..To evaluate the efficacy and safety of 30, 50, and 70 mg/day lisdexamfetamine dimesylate compared with placebo in adults with attention-deficit/hyperactivity disorder (ADHD)...
  54. ncbi Age-dependent decline of symptoms of attention deficit hyperactivity disorder: impact of remission definition and symptom type
    J Biederman
    Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 157:816-8. 2000
    ..Symptom decline in attention deficit hyperactivity disorder (ADHD) was examined with different definitions of remission...
  55. ncbi Neuropsychology of adults with attention-deficit/hyperactivity disorder: a meta-analytic review
    Aaron S Hervey
    Department of Psychology, Duke University, Durham, NC 27705, USA
    Neuropsychology 18:485-503. 2004
    ..Future directions for research based on these findings are highlighted, including further exploration of specific impairments and an emphasis on particular tests and testing conditions...
  56. ncbi Executive function deficits in autism spectrum disorders and attention-deficit/hyperactivity disorder: examining profiles across domains and ages
    Francesca Happe
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Brain Cogn 61:25-39. 2006
    ..Within the present groups, the overall findings suggested less severe and persistent EF deficits in ASD (including Asperger Syndrome) than in ADHD...
  57. pmc The prevalence and correlates of adult ADHD in the United States: results from the National Comorbidity Survey Replication
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115, USA
    Am J Psychiatry 163:716-23. 2006
    ..Despite growing interest in adult attention deficit hyperactivity disorder (ADHD), little is known about its prevalence or correlates...
  58. ncbi Altered resting-state functional connectivity patterns of anterior cingulate cortex in adolescents with attention deficit hyperactivity disorder
    Lixia Tian
    National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, PR China
    Neurosci Lett 400:39-43. 2006
    ..We suggest these abnormally more significant functional connectivities in the ADHD patients may indicate the abnormality of autonomic control functions in them...
  59. pmc Attention-deficit/hyperactivity disorder and urinary metabolites of organophosphate pesticides
    Maryse F Bouchard
    Department of Environmental Health, School of Public Health, Harvard University, Boston, MA, USA
    Pediatrics 125:e1270-7. 2010
    ..The goal was to examine the association between urinary concentrations of dialkyl phosphate metabolites of organophosphates and attention-deficit/hyperactivity disorder (ADHD) in children 8 to 15 years of age...
  60. ncbi Neurobiology of ADHD
    Gail Tripp
    Human Developmental Neurobiology Unit, Okinawa Institute of Science and Technology, 12 22 Suzaki, Uruma City, Okinawa 904 2234, Japan
    Neuropharmacology 57:579-89. 2009
    ..We discuss how a failure of this transfer may give rise to many symptoms of ADHD, and propose that methylphenidate might act to compensate for the proposed dopamine transfer deficit...
  61. pmc The spontaneously hypertensive rat model of ADHD--the importance of selecting the appropriate reference strain
    Terje Sagvolden
    Institute of Basic Medical Sciences, University of Oslo, Norway
    Neuropharmacology 57:619-26. 2009
    ..Finally, we argue that WKY rats obtained from Charles River, Germany (WKY/NCrl) provide a promising model for the predominantly inattentive subtype of ADHD (ADHD-PI); in this case also the WKY/NHsd substrain should be used as control...
  62. pmc Case-control genome-wide association study of attention-deficit/hyperactivity disorder
    Benjamin M Neale
    Center for Human Genetic Research, Massachusettes General Hospital, Boston, MA, USA
    J Am Acad Child Adolesc Psychiatry 49:906-20. 2010
    ..Thus additional genomewide association studies (GWAS) are needed...
  63. ncbi Reward anticipation and outcomes in adult males with attention-deficit/hyperactivity disorder
    Andreas Strohle
    Department of Psychiatry and Psychotherapy, Campus Charite Mitte, Charite Universitatsmedizin Berlin, Schumannstr 20 21, 10117 Berlin, Germany
    Neuroimage 39:966-72. 2008
    ..These findings suggest that male adults with ADHD show neural signs of abnormal reward processing. Future studies will have to investigate whether these dysfunctional patterns might be normalized by treatment...
  64. ncbi Once-a-day Concerta methylphenidate versus three-times-daily methylphenidate in laboratory and natural settings
    W E Pelham
    Department of Psychology, State University of New York at Buffalo, Buffalo, New York, USA
    Pediatrics 107:E105. 2001
    ..This study tests the efficacy and duration of action, in natural and laboratory settings, of an extended-release MPH preparation designed to last 12 hours and therefore be equivalent to 3-times-daily dosing...
  65. pmc Attention deficit/hyperactivity disorder symptoms moderate cognition and behavior in children with autism spectrum disorders
    Benjamin E Yerys
    Children s Research Institute Neuroscience, Children s National Medical Center, Washington, District of Columbia 20010, USA
    Autism Res 2:322-33. 2009
    ..Therefore, ADHD may moderate the expression of components of the ASD cognitive and behavioral phenotype, but ASD+ADHD may not represent an etiologically distinct phenotype from ASD alone...
  66. pmc Clinical and cognitive characteristics of children with attention-deficit hyperactivity disorder, with and without copy number variants
    Kate Langley
    Department of Psychological Medicine and Neurology, and MRC Centre for Neuropsychiatric Genetics, Cardiff University, Cardiff, UK
    Br J Psychiatry 199:398-403. 2011
    ..Submicroscopic, rare chromosomal copy number variants (CNVs) contribute to neurodevelopmental disorders but it is not known whether they define atypical clinical cases...
  67. ncbi Time trends in adolescent mental health
    Stephan Collishaw
    MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    J Child Psychol Psychiatry 45:1350-62. 2004
    ..Few studies have examined this issue using the same instruments at each time point...
  68. ncbi A comparison of the efficacy of medications for adult attention-deficit/hyperactivity disorder using meta-analysis of effect sizes
    Stephen V Faraone
    Department of Psychiatry, SUNY Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA
    J Clin Psychiatry 71:754-63. 2010
    ....
  69. ncbi Efficacy and tolerability of lisdexamfetamine dimesylate (NRP-104) in children with attention-deficit/hyperactivity disorder: a phase III, multicenter, randomized, double-blind, forced-dose, parallel-group study
    Joseph Biederman
    Department of Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Clin Ther 29:450-63. 2007
    ..Following ingestion, the pharmacologically active d-amphetamine molecule is gradually released by rate-limited hydrolysis...
  70. pmc Prenatal organochlorine exposure and behaviors associated with attention deficit hyperactivity disorder in school-aged children
    Sharon K Sagiv
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 171:593-601. 2010
    ..76, 95% confidence interval: 1.06, 2.92) and a similar relation for p,p'-DDE. These results support an association between low-level prenatal organochlorine exposure and ADHD-like behaviors in childhood...
  71. pmc Very early predictors of adolescent depression and suicide attempts in children with attention-deficit/hyperactivity disorder
    Andrea Chronis-Tuscano
    Department of Psychology, University of Maryland, College Park, USA
    Arch Gen Psychiatry 67:1044-51. 2010
    ..Concrete suicidal ideation and attempts during adolescence are particularly associated with significant distress, morbidity, and risk for completed suicide...
  72. ncbi Depressed dopamine activity in caudate and preliminary evidence of limbic involvement in adults with attention-deficit/hyperactivity disorder
    Nora D Volkow
    National Institute on Drug Abuse, 6001 Executive Blvd, Room 5274, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:932-40. 2007
    ..There is considerable evidence that brain dopamine is involved in ADHD, but it is unclear whether dopamine activity is enhanced or depressed...
  73. pmc European guidelines on managing adverse effects of medication for ADHD
    J Graham
    Child and Adolescent Psychiatry, The Centre for Child Health, Dundee, UK
    Eur Child Adolesc Psychiatry 20:17-37. 2011
    ..Some of the effects examined appeared to be minimal in impact or difficult to distinguish from risk to untreated populations. However, several areas require further study to allow a more precise understanding of these risks...
  74. ncbi Long-acting medications for the hyperkinetic disorders. A systematic review and European treatment guideline
    Tobias Banaschewski
    Dept of Child and Adolescent Psychiatry Psychotherapy, University of Goettingen, Von Siebold Str 5, 37075 Goettingen, Germany
    Eur Child Adolesc Psychiatry 15:476-95. 2006
    ..Individual clinical choice is needed. (3) Both ATX and extended-release preparations of stimulants should be available. The choice will depend upon the circumstances, and detailed recommendations are made...
  75. pmc What causes attention deficit hyperactivity disorder?
    Anita Thapar
    Department of Psychological Medicine and Neurology, Cardiff University School of Medicine, Cardiff, UK
    Arch Dis Child 97:260-5. 2012
    ..In this review, the authors consider recent developments in the understanding of risk factors that influence ADHD...
  76. pmc A population-based study of attention deficit/hyperactivity disorder symptoms and associated impairment in middle-aged adults
    Debjani Das
    John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia
    PLoS ONE 7:e31500. 2012
    ..Thus, there is a compelling need for better understanding and development of age-appropriate approaches to the diagnosis and treatment of ADHD in mid- to late-life...
  77. ncbi Spontaneous attentional fluctuations in impaired states and pathological conditions: a neurobiological hypothesis
    Edmund J S Sonuga-Barke
    Developmental Brain and Behaviour Unit, School of Psychology, University of Southampton, Southampton, UK
    Neurosci Biobehav Rev 31:977-86. 2007
    ..Finally, we explore the putative role of default-mode interference as a cause of performance variability in attention deficit/hyperactivity disorder...
  78. ncbi Genetic and environmental influences on ADHD symptom dimensions of inattention and hyperactivity: a meta-analysis
    Molly A Nikolas
    Department of Psychology, Michigan State University, East Lansing, MI 48824, USA
    J Abnorm Psychol 119:1-17. 2010
    ..These findings highlight the need for future studies to disambiguate INATT and HYP when investigating the causal mechanisms, and particularly genetic influences, behind ADHD...
  79. ncbi Misuse and diversion of stimulants prescribed for ADHD: a systematic review of the literature
    Timothy E Wilens
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Am Acad Child Adolesc Psychiatry 47:21-31. 2008
    ..The purpose of this systematic review of the literature is to evaluate the extent and characteristics of stimulant misuse and diversion in attention-deficit/hyperactivity disorder (ADHD) and non-ADHD individuals...
  80. pmc Predictors of persistent ADHD: an 11-year follow-up study
    Joseph Biederman
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, YAW 6A 6900, Boston, MA 02114, USA
    J Psychiatr Res 45:150-5. 2011
    ..The main aim of this study was to evaluate predictors of persistence of ADHD in a large sample of boys with and without ADHD followed prospectively for 11 years into young adulthood...
  81. pmc Large-scale brain systems in ADHD: beyond the prefrontal-striatal model
    F Xavier Castellanos
    Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, Child Study Center, NYU Langone School of Medicine, New York, NY, USA
    Trends Cogn Sci 16:17-26. 2012
    ....
  82. ncbi Overweight in children and adolescents in relation to attention-deficit/hyperactivity disorder: results from a national sample
    Molly E Waring
    Department of Community Health, Brown Medical School, Box G S121, Providence, RI 02912, USA
    Pediatrics 122:e1-6. 2008
    ..The current study estimated the prevalence of overweight in children and adolescents in relation to attention-deficit/hyperactivity disorder and medication use...
  83. pmc Advances in understanding and treating ADHD
    Kevin M Antshel
    State University of New York, Upstate Medical University, Department of Psychiatry and Behavioral Sciences, 750 East Adams Street, Syracuse, NY 13210, USA
    BMC Med 9:72. 2011
    ....
  84. pmc Prenatal smoking might not cause attention-deficit/hyperactivity disorder: evidence from a novel design
    Anita Thapar
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, United Kingdom
    Biol Psychiatry 66:722-7. 2009
    ..It is, however, impossible to be certain of adequate control for confounding factors with observational designs. We use a novel "natural experiment" design that separates prenatal environmental from alternative inherited effects...
  85. pmc Understanding the effects of stimulant medications on cognition in individuals with attention-deficit hyperactivity disorder: a decade of progress
    James Swanson
    Department of Pediatrics, University of California, Irvine, CA, USA
    Neuropsychopharmacology 36:207-26. 2011
    ..We will review some key findings from the recent literature, and then offer interpretations of the progress that has been made over the past decade in understanding the cognitive effects of stimulant medication on individuals with ADHD...
  86. pmc Cognitive behaviour therapy in medication-treated adults with ADHD and persistent symptoms: a randomized controlled trial
    Brynjar Emilsson
    King s College London, Institute of Psychiatry, De Crespigny Park, London, UK
    BMC Psychiatry 11:116. 2011
    ..The main aim of the current study was to evaluate a newly developed cognitive behaviour therapy (CBT) based group programme, the Reasoning and Rehabilitation for ADHD Youths and Adults (R&R2ADHD), using a randomized controlled trial...
  87. pmc Family-based genome-wide association scan of attention-deficit/hyperactivity disorder
    Eric Mick
    Massachusetts General Hospital, 55 Fruit Street Warren 705, Boston, MA 02114, USA
    J Am Acad Child Adolesc Psychiatry 49:898-905.e3. 2010
    ..We have conducted a third, independent, multisite GWAS of DSM-IV-TR ADHD...
  88. ncbi Attention-deficit/hyperactivity disorder and behavioral inhibition: a meta-analytic review of the stop-signal paradigm
    R Matt Alderson
    Department of Psychology, University of Central Florida, P O Box 161390, Orlando, FL 32816 1390, USA
    J Abnorm Child Psychol 35:745-58. 2007
    ..Several subject and task variables served as significant moderators for children's mean reaction time...
  89. ncbi Efficacy of neurofeedback treatment in ADHD: the effects on inattention, impulsivity and hyperactivity: a meta-analysis
    Martijn Arns
    Brainclinics Diagnostics, Nijmegen, The Netherlands
    Clin EEG Neurosci 40:180-9. 2009
    ....
  90. pmc Attention-deficit/hyperactivity disorder and attention networks
    George Bush
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Neuropsychopharmacology 35:278-300. 2010
    ..The review will conclude by suggesting possible avenues for future research...
  91. pmc Structural brain change in Attention Deficit Hyperactivity Disorder identified by meta-analysis
    Ian Ellison-Wright
    Avon and Wiltshire Mental Health Partnership NHS Trust, Salisbury, UK
    BMC Psychiatry 8:51. 2008
    ..The authors sought to map gray matter changes in Attention Deficit Hyperactivity Disorder (ADHD) using a novel technique incorporating neuro-imaging and genetic meta-analysis methods...
  92. ncbi A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication
    M Arcos-Burgos
    National Human Genome Research Institute, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892, USA
    Mol Psychiatry 15:1053-66. 2010
    ..Linkage and replicated association of ADHD with a novel non-candidate gene (LPHN3) provide new insights into the genetics, neurobiology, and treatment of ADHD...
  93. ncbi Symptom profiles in children with ADHD: effects of comorbidity and gender
    J H Newcorn
    Department of Psychiatry, Mount Sinai School of Medicine, USA
    J Am Acad Child Adolesc Psychiatry 40:137-46. 2001
    ....
  94. ncbi Internal and external validity of attention-deficit hyperactivity disorder in a population-based sample of adults
    J J Sandra Kooij
    Parnassia, Psycho medical Centre, Den Haag, The Netherlands
    Psychol Med 35:817-27. 2005
    ..Follow-up studies of childhood ADHD have shown persistence of the disorder into adulthood, but no epidemiological data are yet available...
  95. ncbi Clinical utility of EEG in attention deficit hyperactivity disorder
    Sandra K Loo
    UCLA Neuropsychiatric Institute, Los Angeles, California 90024, USA
    Appl Neuropsychol 12:64-76. 2005
    ....
  96. ncbi Behavioral and neural consequences of prenatal exposure to nicotine
    M Ernst
    Brain Imaging Center in the Neuroimaging Branch of the Intramural Research Program of the National Institute on Drug Abuse, Bethesda, MD 20892 0135, USA
    J Am Acad Child Adolesc Psychiatry 40:630-41. 2001
    ..The relatively high rate of tobacco smoking among pregnant women (25% of all pregnancies in the U.S.) underlines the seriousness of these concerns...
  97. ncbi An integrative theory of attention-deficit/ hyperactivity disorder based on the cognitive and affective neurosciences
    Joel T Nigg
    Department of Psychology, Michigan State University, East Lansing 48824 1116, USA
    Dev Psychopathol 17:785-806. 2005
    ..In turn, such decrement could lead to many of the phenotypic cognitive and neuropsychological features seen in children with ADHD...
  98. ncbi Clinical responses to atomoxetine in attention-deficit/hyperactivity disorder: the Integrated Data Exploratory Analysis (IDEA) study
    Jeffrey H Newcorn
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Am Acad Child Adolesc Psychiatry 48:511-8. 2009
    ..We conducted a retrospective analysis of randomized controlled trials (RCTs) to identify potential baseline (moderator) and on-treatment (mediator) predictors of responses...
  99. pmc Meta-analysis: treatment of attention-deficit/hyperactivity disorder in children with comorbid tic disorders
    Michael H Bloch
    Yale Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    J Am Acad Child Adolesc Psychiatry 48:884-93. 2009
    ..We sought to determine the relative efficacy of different medications in treating ADHD and tic symptoms in children with both Tourette's syndrome and ADHD...
  100. ncbi Adolescent clinical outcomes for young people with attention-deficit hyperactivity disorder
    Kate Langley
    Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Br J Psychiatry 196:235-40. 2010
    ..Attention-deficit hyperactivity disorder (ADHD) is recognised as a common, disabling condition. Little information is available regarding the long-term outcomes for individuals with ADHD in the UK...
  101. pmc Molecular genetics of attention deficit hyperactivity disorder
    Stephen V Faraone
    Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210 2375, USA
    Psychiatr Clin North Am 33:159-80. 2010
    ....

Research Grants63

  1. Adult Outcome of Attention Deficit Hyperactivity Disorder
    Joseph Biederman; Fiscal Year: 2007
    ..For these reasons, we expect the proposed work to clarify the course and outcome of ADHD. ..
  2. PREVENTION OF CIGARETTE SMOKING IN ADHD YOUTH
    Joseph Biederman; Fiscal Year: 2001
    ..Since there are estimated to be 3.5 million children with ADHD and 20% have been shown to be smokers, targeting this group could potentially impact 700,000 children and adolescents. ..
  3. Developmental Neuroendocrine Effects of PCBs and PBDEs: Parallels with ADHD
    RICHARD FIELD SEEGAL; Fiscal Year: 2010
    Genetic and endocrine factors are implicated in the etiology of attention deficit disorder with hyperactivity (ADHD)...
  4. Neonatal Biomarkers in Extremely Preterm Babies Predict Childhood Brain Disorders
    Karl Kuban; Fiscal Year: 2013
    ..Elgan-2 will evaluate the relationship between early biomarkers (placental characteristics and blood proteins) and neurological, neurocognitive and neurobehavioral dysfunction and brain structural abnormalities at nine years. ..
  5. A New Statistical Paradigm for Measuring Psychopathology Dimensions in Youth
    Robert D Gibbons; Fiscal Year: 2013
    ..We will then calibrate the item bank using a bifactor IRT model and then develop, test and validate CAT-based administration. ..
  6. Non-Genetic Transmission of Genetic Risk: Mechanism and Relevance to Psychiatric
    Miklos Toth; Fiscal Year: 2012
    ..This opens up opportunities to develop unconventional therapeutic approaches that could increase the specificity of treatments and avoid side effects associated with current medications. ..
  7. MOLECULAR BASIS OF SELECTED GXE EFFECTS IN COMBINED TYPE ADHD
    Alexandre A Todorov; Fiscal Year: 2012
    ....
  8. NEUROPSYCHOLOGY, BEHAVIOR DISORDER & DELINQUENCY RISK
    Terrie Moffitt; Fiscal Year: 1991
    ..The longitudinal risk design of the PYS is well-suited to supporting these research goals...
  9. Bupropion in Adolescents with Comorbid ADHD & Depression
    WILLIAM DAVISS; Fiscal Year: 2007
    ..abstract_text> ..
  10. DOPAMINE TRANSPORTER IMAGING WITH FLUORINE-18 PET
    JOHN NEUMEYER; Fiscal Year: 2003
    ..The lead compound in this series (presently BRL-308) will be evaluated by PET imaging and pharmacokinetics, in non-human primates. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
  11. DOPAMINE TRANSPORTER IMAGING WITH FLUORINE-18 PET
    JOHN NEUMEYER; Fiscal Year: 2000
    ..There is a need for [18F] FP-CIT for PET imaging primarily for the research community. The availability of a kit for easy production of [18F] FP-CIT or related improved ligands will meet this need. ..
  12. AUDITORY TEMPORAL PROCESSING IN CHILDREN WITH DSYLEXIA
    Joshua Breier; Fiscal Year: 2000
    ..This allows for a comparison of the two hypotheses. ..
  13. Collaborative Pediatric Bipolar Disorder Conference
    Joseph Biederman; Fiscal Year: 2007
    ..While the proposed conference does not intend to solve all outstanding problems associated with pediatric bipolar disorder, it will provide a forum to begin formulating a solution. ..
  14. LONGITUDINAL FOLLOW UP OF ADHD GIRLS AND THEIR SIBLINGS
    Joseph Biederman; Fiscal Year: 2002
    ....
  15. Course of psychopathology in female youth: Analysis with extant longitudinal data
    Joseph Biederman; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  16. PEER-BASED DIFFERENCES IN SUBGROUPS OF ADHD BOYS
    J Hodgen; Fiscal Year: 1993
    ..Children with attention deficit disorder with hyperactivity (ADD+H) have been described as more aggressive, disruptive, and impulsive, whereas children ..
  17. Juvenile Bipolar Disorder and Substance Abuse
    Timothy E Wilens; Fiscal Year: 2010
    ..Since BPD is identifiable and treatable, findings from the four-year follow-up will provide valuable information to formulate prevention and early intervention strategies. ..
  18. Substance Abuse in ADHD Girls
    Timothy Wilens; Fiscal Year: 2006
    ..Thus, the research, approach, and goals of this R01 application are consistent with those underscored in the PA and by the Institute of Medicine as being of the highest research priority. ..
  19. LONG TERM DRUG ABUSE IN ADHD
    Timothy Wilens; Fiscal Year: 2002
    ..abstract_text> ..
  20. Biochemical pathways and biomarkers of alcohol injury in early human development
    GABRIELA CEZAR; Fiscal Year: 2009
    ..Most importantly, the candidate clinical biomarkers discovered in this study may be contribute to prevention of FASD since they could be used in prenatal screening to identify pregnant women at risk and their affected offspring. ..
  21. PSYCHOMOTOR STIMULANTS AND STIMULUS CONTROL
    VICTOR LATIES; Fiscal Year: 1991
    ....
  22. Evaluation of Stimulant Drugs
    Sharon Wigal; Fiscal Year: 2006
    ..Within-subject PK variability in time-course of serum concentration for each medication will be analyzed, and the time-response characteristics also will be estimated based on PD measures for methylphenidate. ..
  23. Inhibition and Cognition in Adolescent and Adult ADHD
    Joel Nigg; Fiscal Year: 2004
    ....
  24. Predicting Positive Outcomes Among Peer-Rejected Girls
    AMORI MIKAMI; Fiscal Year: 2002
    ..The overall goal is to uncover mediators and moderators of psychopathology among peer-rejected children, towards the end of contributing to interventions for this group at risk for negative outcomes. ..
  25. Parental Influences on Peer Socialization Among Children with ADHD
    AMORI MIKAMI; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  26. PEDIATRIC BIPOLAR COLLABORATIVE MOOD STABILZER TRAIL
    Robert Findling; Fiscal Year: 2003
    ..Lastly, this trial will provide descriptive information on the stability of acute phase response to monotherapy over a 16 week continuation phase. ..
  27. METHYLPHENIDATE TREATMENT OF ADHD IN CHILDREN WITH TS
    Kenneth Gadow; Fiscal Year: 2004
    ..To evaluate the impact of tic severity and comorbid internalizing and externalizing symptoms on clinical outcome, children with ADHD/+tics will be compared with an additional sample of children with ADHD/-tics at ages 11 and 16 years. ..
  28. Validating Novel Familial Phenotypes of Drug Abuse
    Stephen Faraone; Fiscal Year: 2007
    ..State of the art statistical techniques will be employed. ..
  29. Analysis of an ADHD Whole Genome Association Scan
    Stephen Faraone; Fiscal Year: 2007
    ..All genotype data generated by the GAIN whole genome association scan will be made available to the scientific community by GAIN as soon as the genotypes are completed. [unreadable] [unreadable] [unreadable]..
  30. International Multi-Center ADHD Genetics Project
    Stephen Faraone; Fiscal Year: 2007
    ..abstract_text> ..
  31. TESTING THE VALIDITY OF ADULT ATTENTION DEFICIT DISORDER
    Stephen Faraone; Fiscal Year: 2002
    ..Thus, if founded, we expect that the proposed work will lead to a program of research that can both clarify the nosological complexities of adult ADHD and clarify the nature of genes that are risk factors for the disorder. ..
  32. Response Variability in Children with ADHD
    JEFF EPSTEIN; Fiscal Year: 2009
    ..Finally, relations between response variability on neuropsychological tests and response variability in a variety of real-world analog situations will be examined to evaluate the ecological validity of these deficits. ..
  33. 2/5-The Psychiatric GWAS Consortium: Integrated & Coordinated GWAS Meta-Analyses
    Stephen Faraone; Fiscal Year: 2008
    ..Finally, the PGC proposes to abide as fully as possible with the NIH's GWAS data sharing policies and we provide a detailed data sharing plan and timetable. [unreadable] [unreadable] [unreadable]..
  34. Searching for ADHD Susceptibility Genes
    Stephen V Faraone; Fiscal Year: 2010
    ..That, in turn, should facilitate the search for newer, more effective treatments for the disorder. ..
  35. PROMOTING EVIDENCE-BASED ADHD TREATMENT IN THE COMMUNITY
    JEFF EPSTEIN; Fiscal Year: 2003
    ..The study design will allow for between-groups and within-group comparisons of pediatricians' utilization of the infrastructure, pediatricians' practice behaviors, child outcomes, consumer satisfaction, and costs. ..
  36. AN ECOGENETIC STUDY OF ADHD
    Stephen Faraone; Fiscal Year: 2003
    ..Furthermore, no studies have used an ecogenetic approach to sharpen the accuracy of risk prediction. ..
  37. Functional neuroanatomical deficits in ADHD families
    Scott Kollins; Fiscal Year: 2004
    ..Imaging will be performed at corresponding imaging sites at DUMC, Weill Medical College of Cornell University, and Stanford University respectively. ..
  38. ADHD Phenotype Network: Animal Model to Clinical Trial
    Floyd Sallee; Fiscal Year: 2004
    ..abstract_text> ..
  39. CLONIDINE IN ADHD
    Floyd Sallee; Fiscal Year: 2005
    ..abstract_text> ..
  40. ADHD: Detection and Service Use
    Regina Bussing; Fiscal Year: 2008
    ..The research team has an extensive track record of success with similar study designs and will use innovative technologies to adhere to an efficient management plan. ..
  41. Genetic Underpinnings of EEG Patterns in ADHD
    Sandra Loo; Fiscal Year: 2006
    ..Given the applicant's prior training, proposed mentorship, and outstanding resources, a K23 Award will enable her to become an independent and productive researcher in the genetics and developmental neuropsychology of ADHD. ..
  42. Genetics of EEG Patterns in ADHD
    Sandra K Loo; Fiscal Year: 2010
    ..We are thus able to collect EEG data at a very low cost in a well characterized sample of ADHD ASPs upon which linkage studies (and candidate gene association work) are readily available. ..
  43. Etiology of Reading Disabilities and Comorbid ADHD
    Erik Willcutt; Fiscal Year: 2009
    ..abstract_text> ..
  44. Smoking reinforcement in adults with and without ADHD
    Scott H Kollins; Fiscal Year: 2010
    ..This project will help identify some of the reasons why people with ADHD smoke more and will potentially lead to better prevention and treatment programs. ..
  45. CHILDHOOD STIMULANT EXPOSURE IMPACT ON LATER DRUG ABUSE
    Francisco Castellanos; Fiscal Year: 2008
    ..abstract_text> ..
  46. Predicting Response to Atomoxetine and Methlyphenidate
    Jeffrey Newcorn; Fiscal Year: 2009
    ..abstract_text> ..
  47. Neural Dissection of Hyperactivity/Inattention in Autism
    Francisco Xavier Castellanos; Fiscal Year: 2010
    ..If successful, we will be able to better understand the types of brain mechanisms that are involved in hyperactivity and inattention in children with autism and then be able to use that information to guide targeted treatment studies. ..
  48. Neural Substrates of Variability in Attention Deficit Hyperactivity Disorder (ADH
    Francisco Xavier Castellanos; Fiscal Year: 2010
    ..Achieving such a level of detailed information about brain functioning in ADHD would have major impact on our ability to improve methods of diagnosing ADHD and of developing new treatments. ..
  49. Follow up of the PATS sample
    Scott Kollins; Fiscal Year: 2008
    ..Aim 4 is to determine the stability of the ADHD diagnosis and other comorbidities made for study entry at age 3-5 years across subsequent development [unreadable] [unreadable]..
  50. MAINTENANCE TREATMENT FOR PREVENTION OF SMOKING RELAPSE
    Lirio Covey; Fiscal Year: 2004
    ..abstract_text> ..
  51. Dopamine and ADHD: A Research Infrastructure Network
    Jeffrey Newcorn; Fiscal Year: 2004
    ..In addition, the post-doctoral students will be able to spend time in multiple laboratories, which will facilitate the transfer of key theoretical and technical expertise across sites. ..
  52. DSM-IV ADHD IN AN ETHNICALLY DIVERSE COMMUNITY SAMPLE
    Erik Willcutt; Fiscal Year: 2004
    ..abstract_text> ..
  53. Estrogen, Stress and Dysfunction of Prefrontal Cortex
    Amy Arnsten; Fiscal Year: 2005
    ..This research will begin to reveal how estrogen amplifies the neurochemical cascades that lead to activation of CREB and dysfunction of the PFC during stress ..
  54. Partners in Care for Children
    Bonnie Zima; Fiscal Year: 2006
    ..b. to identify child, provider and system characteristics that are associated with clinical processes, appropriateness of care and outcomes. ..
  55. Validity of DSM-IV ADHD Subtypes in a Community Sample
    Erik Willcutt; Fiscal Year: 2005
    ....
  56. Methylphenidate Abuse Potential in ADHD Adults
    Scott Kollins; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  57. Pharmacological Treatment of ADHD in Young Children
    Christopher Kratochvil; Fiscal Year: 2007
    ..abstract_text> ..
  58. GENETICS OF ADHD
    Josephine Elia; Fiscal Year: 2007
    ..Dr. Douglas Levinson will provide mentoring in statistical methods and data analyses and Dr. Judith Rapoport will provide mentoring in defining novel phenotypic definitions for ADHD. ..
  59. COGNITIVE LOSS WITH AGE--ROLE OF CORTICAL CATECHOLAMINES
    Amy Arnsten; Fiscal Year: 2007
    ..abstract_text> ..
  60. The Reinforcing Mechanisms of Smoking in Adult ADHD
    JEAN GEHRICKE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  61. Mechanisms of Nicotine Dependence in ADHD Adults
    Scott Kollins; Fiscal Year: 2008
    ..Data generated will also lead to subsequent clinical projects to develop more effective interventions for nicotine dependence in this high risk group. [unreadable] [unreadable] [unreadable]..
  62. Enhancing School-Based Services for ADHD Students
    DESIREE MURRAY; Fiscal Year: 2003
    ..abstract_text> ..